Enter Your Search:
Results 1-3 (3)
Go to page number:
Select a Filter Below
Cerebral Cortex (New York, NY) (1)
Clinical immunology (Orlando, Fla.) (1)
The open bioinformatics journal (1)
Svojanovsky, Stan (3)
Abdou, Nabih I (1)
Boudrias, Marie-Hélène (1)
Cheney, Paul D. (1)
Greenwell, Cindy (1)
Kimler, Bruce F. (1)
Lee, Sang-Pil (1)
Lushington, Gerald H. (1)
Mathur, Sachin (1)
Rider, Virginia (1)
Smith, Peter (1)
Smith, Peter G. (1)
Srinivas, Adagarla B. (1)
Visvanathan, Mahesh (1)
Walters, Emily (1)
Yoo, Byunggil (1)
Year of Publication
Forelimb Muscle Representations and Output Properties of Motor Areas in the Mesial Wall of Rhesus Macaques
Cheney, Paul D.
Cerebral Cortex (New York, NY)
In this study, forelimb organizations and output properties of the supplementary motor area (SMA) and the dorsal cingulate motor area (CMAd) were assessed and compared with primary motor cortex (M1). Stimulus-triggered averages of electromyographic activity from 24 muscles of the forelimb were computed from layer V sites of 2 rhesus monkeys performing a reach-to-grasp task. No clear segregation of the forelimb representation of proximal and distal muscles was found in SMA. In CMAd, sites producing poststimulus effects in proximal muscles tended to be located caudal to distal muscle sites, although the number of effects was limited. For both SMA and CMAd, facilitation effects were more prevalent in distal than in proximal muscles. At an intensity of 60 μA, the mean latencies of M1 facilitation effects were 8 and 12.1 ms shorter and the magnitudes ∼10 times greater than those from SMA and CMAd. Our results show that corticospinal neurons in SMA and CMAd provide relatively weak input to spinal motoneurons compared with the robust effects from M1. However, a small number of facilitation effects from SMA and CMAd had latencies as short as the shortest ones from M1 suggesting a minimum linkage to motoneurons as direct as that from M1.
corticospinal neuron; EMG; forelimb; motor control; primate; supplementary motor area
1 Estradiol Targets T Cell Signaling Pathways in Human Systemic Lupus
Abdou, Nabih I
Kimler, Bruce F.
Clinical immunology (Orlando, Fla.)
The major risk factor for developing systemic lupus erythematosus (SLE) is being female. The present study utilized gene profiles of activated T cells from females with SLE and healthy controls to identify signaling pathways uniquely regulated by estradiol that could contribute to SLE pathogenesis. Selected downstream pathway genes (+/− estradiol) were measured by real time polymerase chain amplification. Estradiol uniquely upregulated six pathways in SLE T cells that control T cell function including interferon-α signaling. Measurement of interferon-α pathway target gene expression revealed significant differences (p = 0.043) in DRIP150 (+/− estradiol) in SLE T cell samples while IFIT1 expression was bimodal and correlated moderately (r = 0.55) with disease activity. The results indicate that estradiol alters signaling pathways in activated SLE T cells that control T cell function. Differential expression of transcriptional coactivators could influence estrogen-dependent gene regulation in T cell signaling and contribute to SLE onset and disease pathogenesis.
SLE; estradiol; interferon-α; T cell signaling; microarray
GOAPhAR: An Integrative Discovery Tool for Annotation, Pathway Analysis
Srinivas, Adagarla B.
Lushington, Gerald H.
Smith, Peter G.
The open bioinformatics journal
We have developed the web based tool GOAPhAR (Gene Ontology, Annotations and Pathways for Array Research), that integrates information from disparate sources regarding gene annotations, protein annotations, identifiers associated with probe sets, functional pathways, protein interactions, Gene Ontology, publicly available microarray datasets and tools for statistically validating clusters in microarray data. Genes of interest can be input as Affymetrix probe identifiers, Genbank, or Unigene identifiers for human, mouse or rat genomes. Results are provided in a user friendly interface with hyperlinks to the sources of information.
GOAPhAR: Gene ontology, Annotations and pathways for array research
Results 1-3 (3)
Go to page number:
Remove citation from clipboard
Add citation to clipboard
This will clear all selections from your clipboard. Do you wish proceed?
Clipboard is full! Please remove an item and try again.
PubMed Central Canada is a service of the
Canadian Institutes of Health Research
(CIHR) working in partnership with the National Research Council's
Canada Institute for Scientific and Technical Information
in cooperation with the
National Center for Biotechnology Information
U.S. National Library of Medicine
(NCBI/NLM). It includes content provided to the
PubMed Central International archive
by participating publishers.