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American Journal of Pharmaceutical Education (1)
Expert review of anti-infective therapy (1)
Gilligan, Adrienne M. (1)
Hensley, Scott E (1)
Holdford, David (1)
Lavigne, Jill E. (1)
Moczygemba, Leticia R. (1)
Myers, Jaclyn (1)
Myers, Jaclyn L (1)
Nash, James D. (1)
Plake, Kimberly S. (1)
Quiñones-Boex, Ana C. (1)
Warholak, Terri L. (1)
West-Strum, Donna (1)
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Educating Pharmacy Students to Improve Quality (EPIQ) in Colleges and Schools of Pharmacy
Gilligan, Adrienne M.
Nash, James D.
Lavigne, Jill E.
Moczygemba, Leticia R.
Plake, Kimberly S.
Quiñones-Boex, Ana C.
Warholak, Terri L.
American Journal of Pharmaceutical Education
Objective. To assess course instructors’ and students’ perceptions of the Educating Pharmacy Students and Pharmacists to Improve Quality (EPIQ) curriculum.
Methods. Seven colleges and schools of pharmacy that were using the EPIQ program in their curricula agreed to participate in the study. Five of the 7 collected student retrospective pre- and post-intervention questionnaires. Changes in students’ perceptions were evaluated to assess their relationships with demographics and course variables. Instructors who implemented the EPIQ program at each of the 7 colleges and schools were also asked to complete a questionnaire.
Results. Scores on all questionnaire items indicated improvement in students’ perceived knowledge of quality improvement. The university the students attended, completion of a class project, and length of coverage of material were significantly related to improvement in the students’ scores. Instructors at all colleges and schools felt the EPIQ curriculum was a strong program that fulfilled the criteria for quality improvement and medication error reduction education.
Conclusion The EPIQ program is a viable, turnkey option for colleges and schools of pharmacy to use in teaching students about quality improvement.
quality improvement; medication error; pharmacy education; pharmacy student; assessment; curriculum
Oseltamivir-resistant influenza viruses get by with a little help from permissive mutations
Hensley, Scott E
Expert review of anti-infective therapy
Influenza A viruses (IAVs) encode two critical glycoproteins, hemagglutinin and neuraminidase (NA). Hemagglutinin promotes viral docking onto cells via interactions with IAV’s receptor, sialic acid and NA facilitates release of newly synthesized virions by cleaving cellular and viral sialic acid. NA inhibitors, such as oseltamivir, are widely used drugs that work by binding to the active site of NA. Although oseltamivir-resistant viruses were easily generated years ago in laboratory experiments, it was widely believed that these viruses would not be able to circulate in the human population as they did not replicate efficiently. However, oseltamivir-resistant H1N1 viruses rapidly spread during the 2007–2008 IAV season and these viruses contained precisely the same exact drug-resistance mutation identified years prior, a histidine to tyrosine substitution at NA residue 274 (H274Y). Unlike the experimentally derived NA inhibitor-resistant viruses, 2007–2008 H1N1 viruses containing H274Y replicated efficiently. Bloom et al. have solved this riddle by identifying permissive NA mutations that allow viruses to tolerate H274Y. Here, we discuss these important findings and speculate how these studies may facilitate early detection of drug-resistant strains in the future.
influenza virus; neuraminidase; neuraminidase inhibitors; oseltamivir
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