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1.  Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye 
Purpose
To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).
Methods
Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.
Results
There was no significant difference in the tear volume between desiccating stress-induced groups. The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.
Conclusions
The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
doi:10.3341/kjo.2015.29.2.131
PMCID: PMC4369516  PMID: 25829831
Dry eye; Hyaluronic acid; Mineral oil; Ocular surface
2.  Developing Korean Academy of Medical Sciences Guideline for Rating the Impairment in Mental and Behavioral Disorders; A Comparative Study of KNPA's New Guidelines and AMA's 6th Guides 
Journal of Korean Medical Science  2009;24(Suppl 2):S338-S342.
Quantifying and rating the impairments due to mental and behavior disorders are difficult for their own characteristics. Korean Academy of Medical Sciences (KAMS) is developing guidelines of rating impairment in mental and behavioral disorders based on Korean Neuropsychiatric Association (KNPA)'s new guidelines. We compared the new KNPA's guidelines and the American Medical Association (AMA)'s 6th Guides in assessing impairment due to mental and behavioral disorders to develop new guidelines of KAMS. Two guidelines are different in diagnosing system, applicable disorders, qualification of assessors, application of scales, contents of assessment and rate of impairment of the whole person. Both AMA's and the proposed guidelines have individual merits and characteristics. There is a limitation in using the 6th AMA's Guides in Korean situation. However to improve objectivity in Korean assessment of psychiatric impairment, the new AMA's Guides can serve as a good reference.
doi:10.3346/jkms.2009.24.S2.S338
PMCID: PMC2690069  PMID: 19503692
Disability Evaluation; Mental Disorders; Behavioral Symptoms
3.  The Utility of Segmental Analysis in Cardiac I-123 MIBG SPECT in Parkinson’s Disease 
Purpose
Cardiac images using I-123 metaiodobenzylguanidine (MIBG) are widely used to evaluate cardiac sympathetic denervation in Parkinson’s disease (PD). The aim of this study was to evaluate the utility of segmental analysis on cardiac MIBG SPECT in PD patients.
Materials and Methods
In total, 36 patients with PD (n = 26) or essential tremor (ET, n = 10) who underwent MIBG cardiac SPECT were enrolled. The heart-to-mediastinum (H/M) ratios of MIBG uptake were acquired on planar images. For the segmental analysis of SPECT images, we evaluated the summed defect score (SDS) using a 17-segment model. The diagnostic abilities of H/M ratios and segmental parameters on MIBG SPECT were assessed by ROC curve analysis.
Results
The H/M ratios were significantly lower in PD than in ET patients (p < 0.05). On segmental analysis, SDS was significantly higher in PD patients than in the ET group (7.04 ± 4.09 vs. 2.90 ± 2.80; p = 0.006). The defect score of the anteroseptal region showed a significant difference between the groups (p = 0.002). The ROC analysis suggested only SDS (AUC = 0.785, p = 0.0003) and defect scores in the anteroseptal (AUC = 0.800, p < 0.0001) and inferior (AUC = 0.667, p = 0.013) regions showed significant diagnostic ability to differentiate PD from ET.
Conclusions
Segmental parameters from cardiac MIBG SPECT images can provide additional information to differentiate PD from ET patients. Beyond H/M ratios from planar images, we recommend an MIBG SPECT study to evaluate sympathetic denervation in PD.
doi:10.1007/s13139-015-0354-0
PMCID: PMC4630334  PMID: 26550049
I-123 MIBG; Heart; SPECT; Parkinson’s disease; Segmental analysis
4.  Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31 
PLoS ONE  2016;11(12):e0167527.
Previously, we showed that B-cell receptor associated protein 31 (BAP31), an endoplasmic reticulum (ER) membrane chaperone, is also expressed on the cell surface by two monoclonal antibodies (MAbs) 297-D4 and 144-A8. Both MAbs recognize the same linear epitope on the C-terminal domain of BAP31, although they were independently established. Here, flow cytometric analysis showed that 144-A8 had additional binding properties to some cells, as compared to 297-D4. Quantitative antigen binding assays also showed that 144-A8 had higher antigen binding capacity than 297-D4. Affinity measurement revealed that 144-A8 had 1.54-fold higher binding affinity than 297-D4. Analysis of the heavy- and light-chain variable region sequences of two MAbs revealed that both MAbs belonged to the same heavy chain (Igh-V3660 VH3) and light chain subgroup (IGKV21) with just two amino acid differences in each framework region, indicating that both MAbs arise from the same germline origin. Seven amino acid differences were found between the complementarity determining regions (CDRs) of the two MAbs. Molecular modeling of the epitope-paratope complexes revealed that the epitope appeared to reside in closer proximity to the CDRs of 144-A8 than to those of 297-D4 with the stronger hydrogen bond interactions with the former than the latter. More interestingly, an additional hydrophobic interaction appeared to be established between the leucine residue of epitope and the paratope of 144-A8, due to the substitution of H-Tyr101 for H-Phe101 in 144-A8. Thus, the different binding specificity and affinity of 144-A8 appeared to be due to the different hydrogen bonds and hydrophobic interaction induced by the alterations of amino acids in CDRs of 144-A8. The results provide molecular insights into how the binding specificities and affinities of antibodies evolve with the same epitope in different microenvironments.
doi:10.1371/journal.pone.0167527
PMCID: PMC5131989  PMID: 27907150
5.  Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry 
Scientific Reports  2016;6:37828.
The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial invagination. Despite the well-defined roles of EK in cusp patterning, the determinants of the ultimate cuspal shapes and involvement of epithelial cellular geometry are unknown. Using two typical tooth patterns, the lophodont in gerbils and the bunodont in mice, we showed that the cuspal shape is determined by the dental epithelium at the cap stage, whereas the cellular geometry in the inner dental epithelium (IDE) is correlated with the cuspal shape. Intriguingly, fine tuning Rac1 and RhoA interconvert cuspal shapes between two species by remolding the cellular geometry. Either inhibition of Rac1 or ectopic expression of RhoA could region-distinctively change the columnar shape of IDE cells in gerbils to drive invagination to produce cusps. Conversely, RhoA reduction in mice inhibited invagination and developed lophs. Furthermore, we found that Rac1 and RhoA modulate the choices of cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin localization to drive IDE invagination.
doi:10.1038/srep37828
PMCID: PMC5124948  PMID: 27892530
6.  Tuning charge and correlation effects for a single molecule on a graphene device 
Nature Communications  2016;7:13553.
The ability to understand and control the electronic properties of individual molecules in a device environment is crucial for developing future technologies at the nanometre scale and below. Achieving this, however, requires the creation of three-terminal devices that allow single molecules to be both gated and imaged at the atomic scale. We have accomplished this by integrating a graphene field effect transistor with a scanning tunnelling microscope, thus allowing gate-controlled charging and spectroscopic interrogation of individual tetrafluoro-tetracyanoquinodimethane molecules. We observe a non-rigid shift in the molecule's lowest unoccupied molecular orbital energy (relative to the Dirac point) as a function of gate voltage due to graphene polarization effects. Our results show that electron–electron interactions play an important role in how molecular energy levels align to the graphene Dirac point, and may significantly influence charge transport through individual molecules incorporated in graphene-based nanodevices.
The development of single-molecule electronics calls for precise tuning of the electronic properties of individual molecules that go beyond two-terminal control. Here, Wickenburg et al. show gate-tunable switch of charge states of an isolated molecule using a graphene-based field-effect transistor.
doi:10.1038/ncomms13553
PMCID: PMC5133630  PMID: 27886170
7.  Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study 
Purpose
To evaluate the blood pressure (BP) lowering efficacy and safety of CKD-828, a fixed-dose combination of S-amlodipine (the more active isomer of amlodipine besylate, which is calcium channel blocker) and telmisartan (long acting angiotensin receptor blocker), in patients with hypertension inadequately controlled with S-amlodipine monotherapy.
Patients and methods
Eligible patients (N=187) who failed to respond after 4-week S-amlodipine 2.5 mg monotherapy (sitting diastolic blood pressure [sitDBP] ≥90 mmHg) to receive CKD-828 2.5/40 mg (n=63), CKD-828 2.5/80 mg (n=63), or S-amlodipine 2.5 mg (n=61) for 8 weeks. The primary efficacy endpoint, mean sitDBP change from baseline to Week 8, was compared between the combination (CKD-828 2.5/40 mg and CKD-828 2.5/80 mg) and S-amlodipine monotherapy groups. The safety was assessed based on adverse events, vital signs, and physical examination findings.
Results
After the 8-week treatment, changes in sitDBP/systolic BP (SBP) were −9.67±6.50/−12.89±11.78, −10.72±6.19/−13.79±9.41, and −4.93±7.26/−4.55±11.27 mmHg in the CKD-828 2.5/40 mg (P<0.0001/P<0.0001), CKD-828 2.5/80 mg (P<0.0001/P<0.0001), and S-amlodipine 2.5 mg (P<0.0001/P=0.0027) groups, respectively, which were all significant BP reductions. At Week 8, the CKD-828 2.5/40 mg (sitDBP/SBP: P=0.0002/P<0.0001) and CKD-828 2.5/80 mg (sitDBP/SBP: P=0.0001/P<0.0001) showed superior BP-lowering effects to S-amlodipine 2.5 mg (P<0.001). At Week 4, all groups showed significant antihypertensive effects but both CKD-828 combinations (CKD-828 2.5/40 mg and CKD-828 2.5/80 mg) exhibited superior BP-lowering effects to that of S-amlodipine 2.5 mg (sitDBP/SBP: P=0.0028/P=0.0001 and P<0.0001/P=0.0012, respectively). The adverse event incidence was significantly lower in the CKD-828 2.5/40 mg (9.52%, P=0.0086) than in the S-amlodipine 2.5 mg group (27.87%) and increasing the telmisartan dose induced no unexpected adverse events, suggesting the safety of CKD-828.
Conclusion
CKD-828 is an effective and safe option for patients with inadequate responses to S-amlodipine monotherapy.
doi:10.2147/DDDT.S116847
PMCID: PMC5125808  PMID: 27920497
blood pressure; antihypertensive; calcium channel blocker; angiotensin receptor blocker; efficacy; safety
8.  Efficacy of BRAF Inhibitors in Asian Metastatic Melanoma Patients: Potential Implications of Genomic Sequencing in BRAF-Mutated Melanoma12 
Translational Oncology  2016;9(6):557-564.
BACKGROUND: The BRAF inhibitors vemurafenib and dabrafenib are currently the standard treatment for metastatic melanoma with BRAF V600 mutations. However, given the rarity of noncutaneous melanoma, including acral and mucosal subtypes, the efficacy of BRAF inhibitors for this subset of patients has not been extensively investigated. Acquired resistance generally appears 6 to 8 months after treatment with a BRAF inhibitor, and the mechanism of resistance is not well established. METHODS: We examined treatment outcomes for patients diagnosed with metastatic melanoma and treated with BRAF inhibitors at Samsung Medical Center between April 2013 and December 2015. We analyzed genomic alterations in selected patients using targeted sequencing. RESULTS: Twenty-seven patients with a median age of 49 years (range 23-82 years) with metastatic melanoma and treated with a BRAF inhibitor were identified. Of these patients, 19 (70.3%) had noncutaneous melanoma, including acral and mucosal melanoma. All patients had BRAFV600E mutations. The median progression-free survival of all patients was 9.2 months (95% confidence interval, 1.6-16.7), and the objective response rate was 78.9% in the mucosal/acral melanoma group and 75.0% in the cutaneous melanoma group. Three (11.1%) patients achieved complete response, and 19 (70.4%) showed a partial response. Targeted sequencing in five patients demonstrated NF1 mutations in three patients who did not respond to BRAF inhibitors. CONCLUSION: BRAF inhibitors were an effective therapeutic option for Korean patients with metastatic melanoma harboring a BRAF V600 mutation regardless of melanoma subtype (acral/mucosa versus cutaneous).
doi:10.1016/j.tranon.2016.09.004
PMCID: PMC5122709  PMID: 27883956
9.  Impact of low high-density lipoprotein-cholesterol level on 2-year clinical outcomes after acute myocardial infarction in patients with diabetes mellitus 
Background
It is still unclear whether low high-density lipoprotein cholesterol (HDL-C) affects cardiovascular outcomes after acute myocardial infarction (AMI), especially in patients with diabetes mellitus.
Methods
A total of 984 AMI patients with diabetes mellitus from the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry were divided into two groups based on HDL-C level on admission: normal HDL-C group (HDL-C ≥ 40 mg/dL, n = 519) and low HDL-C group (HDL-C < 40 mg/dL, n = 465). The primary endpoint was 2-year major adverse cardiovascular events (MACE), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target vessel revascularization (TVR).
Results
The median follow-up duration was 730 days. The 2-year MACE rates were significantly higher in the low HDL-C group than in the normal HDL-C group (MACE, 7.44% vs. 3.49%, p = 0.006; cardiac death, 3.72% vs. 0.97%, p = 0.004; non-fatal MI, 1.75% vs. 1.55%, p = 0.806; TVR, 3.50% vs. 0.97%, p = 0.007). Kaplan-Meier analysis revealed that the low HDL-C group had a significantly higher incidence of MACE compared to the normal HDL-C group (log-rank p = 0.013). After adjusting for conventional risk factors, Cox proportional hazards analysis suggested that low HDL-C was an independent risk predictor for MACE (hazard ratio [HR] 3.075, 95% confidence interval [CI] 1.034-9.144, p = 0.043).
Conclusions
In patients with diabetes mellitus, low HDL-C remained an independent risk predictor for MACE after adjusting for multiple risk factors during 2-year follow-up of AMI.
Trial registration
This study was the sub-analysis of the prospective multi-center registry of DIAMOND (Diabetic acute myocardial infarction Disease) in Korea. This is the observational study supported by Bayer HealthCare, Korea. Study number is 15614. First patient first visit was 02 April 2010 and last patient last visit was 09 December 2013.
Electronic supplementary material
The online version of this article (doi:10.1186/s12944-016-0374-5) contains supplementary material, which is available to authorized users.
doi:10.1186/s12944-016-0374-5
PMCID: PMC5116186  PMID: 27863493
High-density lipoprotein cholesterol; Major adverse cardiovascular events; Acute myocardial infarction; Diabetes mellitus
10.  Whole genome sequence analysis of the TALLYHO/Jng mouse 
BMC Genomics  2016;17:907.
Background
The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred strain at The Jackson Laboratory. TH mice manifest many of the disease phenotypes observed in human obesity and type 2 diabetes.
Results
We sequenced the whole genome of TH mice maintained at Marshall University to a depth of approximately 64.8X coverage using data from three next generation sequencing runs. Genome-wide, we found approximately 4.31 million homozygous single nucleotide polymorphisms (SNPs) and 1.10 million homozygous small insertions and deletions (indels) of which 98,899 SNPs and 163,720 indels were unique to the TH strain compared to 28 previously sequenced inbred mouse strains. In order to identify potentially clinically-relevant genes, we intersected our list of SNP and indel variants with human orthologous genes in which variants were associated in GWAS studies with obesity, diabetes, and metabolic syndrome, and with genes previously shown to confer a monogenic obesity phenotype in humans, and found several candidate variants that could be functionally tested using TH mice. Further, we filtered our list of variants to those occurring in an obesity quantitative trait locus, tabw2, identified in TH mice and found a missense polymorphism in the Cidec gene and characterized this variant’s effect on protein function.
Conclusions
We generated a complete catalog of variants in TH mice using the data from whole genome sequencing. Our findings will facilitate the identification of causal variants that underlie metabolic diseases in TH mice and will enable identification of candidate susceptibility genes for complex human obesity and type 2 diabetes.
Electronic supplementary material
The online version of this article (doi:10.1186/s12864-016-3245-6) contains supplementary material, which is available to authorized users.
doi:10.1186/s12864-016-3245-6
PMCID: PMC5106808  PMID: 27835940
Whole genome sequencing; Obesity; Type 2 diabetes; Mouse model; TALLYHO; Quantitative Trait Loci
11.  The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers 
Molecular carcinogenesis  2014;54(10):1172-1180.
Enhancer of zeste homolog 2 (EZH2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) and its demethylation is catalyzed by UTX. EZH2 levels are frequently elevated in breast cancer and have been proposed to control gene expression through regulating repressive H3K27me3 marks. However, it is not fully established whether breast cancers with different levels of H3K27me3, EZH2 and UTX exhibit different biological behaviors. Levels of H3K27me3, EZH2 and UTX and their prognostic significance were evaluated in one hundred forty six (146) cases of breast cancer. H3K27me3 levels were higher in HER2-negative samples. EZH2 expression was higher in cancers that were LN+, size > 20mm, and with higher tumor grade and stage. Using a Cox regression model, H3K27me3 levels and EZH2 expression were identified as independent prognostic factors for overall survival for all the breast cancers studied as well as the ER-positive subgroup. The combination of low H3K27me3 and high EZH2 expression levels were significantly associated with shorter survival. UTX expression was not significantly associated with prognosis and there were no correlations between H3K27me3 levels and EZH2/UTX expression. To determine if EZH2 is required to establish H3K27me3 marks in mammary cancer, Brca1 and Ezh2 were deleted in mammary stem cells in mice. Brca1-deficient mammary cancers with unaltered H3K27me3 levels developed in the absence of EZH2, demonstrating that EZH2 is not a mandatory H3K27 methyltransferase in mammary neoplasia and providing genetic evidence for biological independence between H3K27me3 and EZH2 in this tissue.
doi:10.1002/mc.22188
PMCID: PMC4286524  PMID: 25043748
histone modification; EZH2; UTX; cancer; prognosis
12.  Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction 
PURPOSE
On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages.
MATERIALS AND METHODS
Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation).
RESULTS
The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study.
CONCLUSION
Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.
doi:10.4047/jap.2016.8.5.363
PMCID: PMC5099128  PMID: 27826386
Postoperative radiotherapy; Head and neck cancer; Local irradiation; Implant; Empty lacuna
14.  Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children 
Stem Cells International  2016;2016:8596520.
The aim of this study was to compare the differential gene expression and stemness in the human gingiva and dental follicles (DFs) according to their biological characteristics. Gingiva (n = 9) and DFs (n = 9) were collected from 18 children. Comparative gene expression profiles were collected using cDNA microarray. The expression of development, chemotaxis, mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSs) related genes was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Histological analysis was performed using hematoxylin-eosin and immunohistochemical staining. Gingiva had greater expression of genes related to keratinization, ectodermal development, and chemotaxis whereas DFs exhibited higher expression levels of genes related to tooth and embryo development. qRT-PCR analysis showed that the expression levels of iPSc factors including SOX2, KLF4, and C-MYC were 58.5 ± 26.3, 12.4 ± 3.5, and 12.2 ± 1.9 times higher in gingiva and VCAM1 (CD146) and ALCAM (CD166) were 33.5 ± 6.9 and 4.3 ± 0.8 times higher in DFs. Genes related to MSCs markers including CD13, CD34, CD73, CD90, and CD105 were expressed at higher levels in DFs. The results of qRT-PCR and IHC staining supported the microarray analysis results. Interestingly, this study demonstrated transcription factors of iPS cells were expressed at higher levels in the gingiva. Given the minimal surgical discomfort and simple accessibility, gingiva is a good candidate stem cell source in regenerative dentistry.
doi:10.1155/2016/8596520
PMCID: PMC5021492  PMID: 27656218
15.  Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation 
Background
Curcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. Here, we investigated the mechanism by which turmeric and curcumin protect the liver against carbon tetrachloride (CCl4)-induced injury in rats. We hypothesized that turmeric extract and curcumin protect the liver from CCl4-induced liver injury by reducing oxidative stress, inhibiting lipid peroxidation, and increasing glutathione peroxidase activation.
Methods
Chronic hepatic stress was induced by a single intraperitoneal injection of CCl4 (0.1 ml/kg body weight) into rats. Turmeric extracts and curcumin were administered once a day for 4 weeks at three dose levels (100, 200, and 300 mg/kg/day). We performed ALT and AST also measured of total lipid, triglyceride, cholesterol levels, and lipid peroxidation.
Result
We found that turmeric extract and curcumin significantly protect against liver injury by decreasing the activities of serum aspartate aminotransferase and alanine aminotransferase and by improving the hepatic glutathione content, leading to a reduced level of lipid peroxidase.
Conclusions
Our data suggest that turmeric extract and curcumin protect the liver from chronic CCl4-induced injury in rats by suppressing hepatic oxidative stress. Therefore, turmeric extract and curcumin are potential therapeutic antioxidant agents for the treatment of hepatic disease.
Electronic supplementary material
The online version of this article (doi:10.1186/s12906-016-1307-6) contains supplementary material, which is available to authorized users.
doi:10.1186/s12906-016-1307-6
PMCID: PMC5000414  PMID: 27561811
Curcumin; Carbon tetrachloride; Oxidative stress; Glutathione; Lipid peroxidase
16.  TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model 
Autophagy  2015;11(10):1760-1774.
Cyclosporine A (CsA) is widely used as an immunosuppressor in transplantation. Previous studies reported that CsA induces autophagy and that chronic treatment with CsA results in accumulation of autophagosomes and reduced autophagic clearance. Autophagy is a prosurvival process that promotes recovery from acute kidney injury by degrading misfolded proteins produced in the kidney. In the present study, we used TMBIM6-expressing HK-2, human kidney tubular cells (TMBIM6 cells) and Tmbim6 knockout (tmbim6−/−) mice. When exposed to CsA, the TMBIM6 cells maintained autophagy activity by preventing autophagosome accumulation. With regard to signaling, PRKKA/AMPK phosphorylation and mechanistic target of rapamycin (serine/threonine kinase) complex 1 (MTORC1) expression and its downstream target TFEB (transcription factor EB), a lysosome biogenesis factor, were regulated in the TMBIM6 cells. Lysosomal activity was highly increased or stably maintained in the presence of TMBIM6. In addition, treatment of tmbim6−/− mice with CsA resulted in increased autophagosome formation and decreased lysosome formation and activity. We also found that tmbim6−/− mice were susceptible to CsA-induced kidney injury. Taken together, these results indicate that TMBIM6 protects against CsA-induced nephrotoxicity both in vitro and in vivo by inducing autophagy and activating lysosomes.
doi:10.1080/15548627.2015.1082021
PMCID: PMC4824609  PMID: 26305401
autophagy; Bax inhibitor-1; cyclosporine A; ER stress; nephrotoxicity
17.  Risk factors for renal impairment revealed after unilateral adrenalectomy in patients with primary aldosteronism 
Medicine  2016;95(27):e3930.
Supplemental Digital Content is available in the text
Abstract
Primary aldosteronism (PA) may induce significant decline of renal function and structural damage of kidney. However, it is difficult to evaluate accurate renal function in patients with PA, because glomerular hyperfiltration and aldosterone escape can conceal renal impairment. In this retrospective cohort study, we compared changes in renal function after unilateral adrenalectomy between patients with PA and patients with other adrenal diseases. Risk factors associated with postoperative renal impairment in patients with PA were analyzed.
A total of 558 patients who received unilateral adrenalectomy between January 2002 and June 2013 were included: 136 patients with PA and 422 patients with other adrenal diseases (control). Postoperative serial changes in estimated glomerular filtration rate (eGFR) were analyzed in both groups. Multivariate analyses were performed to identify risk factors of renal impairment after adrenalectomy in all patients and the PA group. Postoperative renal impairment was defined as postoperative eGFR decline of >25% from preoperative eGFR. Chronic kidney disease (CKD) was defined as an eGFR <60 mL/min/1.73 m2.
There were no differences in preoperative eGFR between groups. The PA group showed a significant decrease in eGFR 3 days, 2 weeks, and 6 months after surgery compared to the control group. The PA group showed significant improvement of hypertension after surgery. In the PA group, 53 (39.0%) patients showed postoperative renal impairment. Multivariate regression analysis identified long-standing hypertension, low body mass index, low serum potassium, and high preoperative eGFR as risk factors for postoperative renal impairment. Among the 89 patients with preoperative eGFR ≥60 mL/min/1.73 m2, 29 (32.6%) patients developed CKD postoperatively. Age, low serum potassium, low preoperative eGFR, and high serum cholesterol or uric acid were associated with the postoperative CKD development.
Our study demonstrates that patients with PA with old age, low serum potassium, long-standing hypertension, and high serum uric acid or cholesterol are at risk of renal impairment after surgical treatment. High preoperative eGFR was also a risk factor for postoperative renal impairment, whereas low preoperative eGFR was a risk factor for postoperative CKD. Close monitoring of renal function and adequate management are required for patients with these risk factors.
doi:10.1097/MD.0000000000003930
PMCID: PMC5058795  PMID: 27399066
adrenalectomy; chronic kidney disease; primary aldosteronism; renal impairment
18.  The Gachon University Ureteral Narrowing score: A comprehensive standardized system for predicting necessity of ureteral dilatation to treat proximal ureteral calculi 
Purpose
For treating proximal ureteral calculi, treatment decision has been known still difficult to choose ureteroscopic lithotripsy (URS) or shockwave lithotripsy. The aims of our study are to identify the possible predictors for necessity of URS and to propose the Gachon University Ureteral Narrowing scoring system (GUUN score) as a helpful predictor.
Materials and Methods
We evaluated 83 consecutive patients who underwent semirigid URS due to proximal ureteral calculi between April 2011 and February 2014 by a single surgeon. We reviewed patient characteristics and pre- and postoperative parameters and surgical records. We divided the patients into 2 groups (group 1, nondilation group; group 2, dilation group) according to whether or not balloon dilation was performed. A stepwise logistic regression was performed to identify the factors that predict dilatation. Receiver operating characteristic (ROC) curves were plotted and areas under the ROC curve (AUC) were calculated to GUUN score.
Results
Mean patients' age and their stone size were 48.53±12.90 years and 7.79±2.57 cm, respectively. Significantly smaller stone size (p=0.009), lower stone density (p=0.005), and lower ureteral density differences between ureteral narrowing level and far distal ureter (UD) (p<0.001) were observed in group 1 (n=34) than in group 2 (n=49). GUUN score consists of age, stone size and UD (AUC, 0.938). Overall stone-free clearance rate was 85.5%.
Conclusions
We suggest that the GUUN score is an excellent scoring system to predict the necessity of ureteral dilatation for decision making whether or not to perform surgical manipulation.
doi:10.4111/icu.2016.57.4.280
PMCID: PMC4949700  PMID: 27437538
Multidetector computed tomography; Ureterolithiasis; Ureteroscopes
19.  Comparison of 2-year clinical outcomes between diabetic versus nondiabetic patients with acute myocardial infarction after 1-month stabilization 
Medicine  2016;95(25):e3882.
Supplemental Digital Content is available in the text
Abstract
This study assessed the 2-year clinical outcomes of patients with diabetes mellitus (DM) after acute myocardial infarction (AMI) in a cohort of the DIAMOND (DIabetic Acute Myocardial infarctiON Disease) registry. Clinical outcomes were compared between 1088 diabetic AMI patients in the DIAMOND registry after stabilization of MI and 1088 nondiabetic AMI patients from the KORMI (Korean AMI) registry after 1 : 1 propensity score matching using traditional cardiovascular risk factors. Stabilized patients were defined as patients who did not have any clinical events within 1 month after AMI. Primary outcomes were the 2-year rate of major adverse cardiac events (MACEs), a composite of all-cause death, recurrent MI (re-MI), and target vessel revascularization (TVR). Matched comparisons revealed that diabetic patients exhibited significantly lower left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate and smaller stent size. Diabetic patients exhibited significantly higher 2-year rates of MACE (8.0% vs 3.7%), all-cause death (3.9% vs 1.4%), re-MI (2.8% vs 1.2%), and TVR (3.5% vs 1.3%) than nondiabetic patients (all P < 0.01), and higher cumulative rates in Kaplan–Meier analyses of MACE, all-cause death, and TVR (all P < 0.05). A multivariate Cox regression analysis revealed that chronic kidney disease, LVEF < 35%, and long stent were independent predictors of MACE, and large stent diameter and the use of drug-eluting stents were protective factors against MACE. The 2-year MACE rate beyond 1 month after AMI was significantly higher in DM patients than non-DM patients, and this rate was associated with higher comorbidities, coronary lesions, and procedural characteristics in DM.
doi:10.1097/MD.0000000000003882
PMCID: PMC4998313  PMID: 27336875
acute myocardial infarction; diabetes mellitus; major adverse cardiac events
20.  Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells 
Licorice extracts containing glycyrrhizin exhibit anti-carcinogenic properties. Because glycyrrhizin induces severe hypokalemia and hypertension, we prepared a hexane/ethanol extract of Glycyrrhiza uralensis (HEGU) that lacks glycyrrhizin, and showed that HEGU induces apoptosis and G1 cell cycle arrest and inhibits migration of DU145 human prostate cancer cells. Our previous in vitro studies identified two active components in HEGU: isoangustone A, which induces apoptosis and G1 cycle arrest, and licoricidin, which inhibits metastasis. This study examined whether HEGU and licoricidin inhibit metastasis using the 4T1 mammary cancer model. Both HEGU and licoricidin treatment reduced pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues. Additionally, a decrease in protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 was noted in tumor tissues of licoricidin-treated mice. Furthermore, the blood concentrations of MMP-9, ICAM-1, VCAM-1, and VEGF-A were decreased in HEGU-treated mice. In vitro 4T1 cell culture results showed that both HEGU and licoricidin inhibited cell migration, MMP-9 secretion, and VCAM expression. The present study demonstrates that the licoricidin in HEGU inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis.
doi:10.3390/ijms17060934
PMCID: PMC4926467  PMID: 27314329
licorice extract; licoricidin; metastasis; breast cancer
21.  The role of the addition of ovarian suppression to tamoxifen in young women with hormone-sensitive breast cancer who remain premenopausal or regain menstruation after chemotherapy (ASTRRA): study protocol for a randomized controlled trial and progress 
BMC Cancer  2016;16:319.
Background
Ovarian function suppression (OFS) has been shown to be effective as adjuvant endocrine therapy in premenopausal women with hormone receptor-positive breast cancer. However, it is currently unclear if addition of OFS to standard tamoxifen therapy after completion of adjuvant chemotherapy results in a survival benefit. In 2008, the Korean Breast Cancer Society Study Group initiated the ASTRRA randomized phase III trial to evaluate the efficacy of OFS in addition to standard tamoxifen treatment in hormone receptor-positive breast cancer patients who remain or regain premenopausal status after chemotherapy.
Methods
Premenopausal women with estrogen receptor-positive breast cancer treated with definitive surgery were enrolled after completion of neoadjuvant or adjuvant chemotherapy. Ovarian function was assessed at the time of enrollment and every 6 months for 2 years by follicular-stimulating hormone levels and bleeding history. If ovarian function was confirmed as premenopausal status, the patient was randomized to receive 2 years of goserelin plus 5 years of tamoxifen treatment or 5 years of tamoxifen alone. The primary end point will be the comparison of the 5-year disease-free survival rates between the OFS and tamoxifen alone groups. Patient recruitment was finished on March 2014 with the inclusion of a total of 1483 patients. The interim analysis will be performed at the time of the observation of the 187th event.
Discussion
This study will provide evidence of the benefit of OFS plus tamoxifen compared with tamoxifen only in premenopausal patients with estrogen receptor-positive breast cancer treated with chemotherapy.
Trial registration
ClinicalTrials.gov Identifier NCT00912548. Registered May 31 2009. Korean Breast Cancer Society Study Group Register KBCSG005. Registered October 26 2009.
doi:10.1186/s12885-016-2354-6
PMCID: PMC4872354  PMID: 27197523
Ovarian function suppression; Goserelin; Tamoxifen; Adjuvant endocrine therapy; Premenopause; Breast cancer
22.  Economic evaluation of manual therapy for musculoskeletal diseases: a protocol for a systematic review and narrative synthesis of evidence 
BMJ Open  2016;6(5):e010556.
Introduction
Manual therapy is the non-surgical conservative management of musculoskeletal disorders using the practitioner's hands on the patient's body for diagnosing and treating disease. The aim of this study is to systematically review trial-based economic evaluations of manual therapy relative to other interventions used for the management of musculoskeletal diseases.
Methods and analysis
Randomised clinical trials (RCTs) on the economic evaluation of manual therapy for musculoskeletal diseases will be included in the review. The following databases will be searched from their inception: Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Econlit, Mantis, Index to Chiropractic Literature, Science Citation Index, Social Science Citation Index, Allied and Complementary Medicine Database (AMED), Cochrane Database of Systematic Reviews (CDSR), National Health Service Database of Abstracts of Reviews of Effects (NHS DARE), National Health Service Health Technology Assessment Database (NHS HTA), National Health Service Economic Evaluation Database (NHS EED), CENTRAL, five Korean medical databases (Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Service System (RISS), DBPIA, Korean Traditional Knowledge Portal (KTKP) and KoreaMed) and three Chinese databases (China National Knowledge Infrastructure (CNKI), VIP and Wanfang). The evidence for the cost-effectiveness, cost-utility and cost-benefit of manual therapy for musculoskeletal diseases will be assessed as the primary outcome. Health-related quality of life and adverse effects will be assessed as secondary outcomes. We will critically appraise the included studies using the Cochrane risk of bias tool and the Drummond checklist. Results will be summarised using Slavin's qualitative best-evidence synthesis approach.
Ethics and dissemination
The results of the study will be disseminated via a peer-reviewed journal and/or conference presentations.
Trial registration number
PROSPERO CRD42015026757.
doi:10.1136/bmjopen-2015-010556
PMCID: PMC4874156  PMID: 27178973
economic evaluation; manual therapy; musculoskeletal diseases; systematic review
23.  Comparison of the RECIST and PERCIST criteria in solid tumors: a pooled analysis and review 
Oncotarget  2016;7(19):27848-27854.
The PET Response Criteria in Solid Tumors (PERCIST) is a new method for the quantitative assessment of metabolic changes in solid tumors. The assessments of tumor response between the RECIST and PERCIST have shown considerable difference in several studies. This pooled study was conducted to compare tumor response according to the two criteria in patients with solid tumors. We surveyed MEDLINE, EMBASE and PUBMED for articles with terms of the RECIST or PERCIST from 2009 and January 2016. There were six articles comparing the RECIST and PERCIST. A total of 268 patients were recruited; 81 with colorectal cancer, 60 with lung cancer, 48 with esophageal cancer, 28 with breast cancer, 14 with basal cell carcinoma, 12 with stomach cancer, 10 with head and neck cancer, and 16 with other rare cancers. The agreement of tumor response between the RECIST and PERCIST was moderate (k = 0.590). Of 268 patients, 101 (37.7%) showed discordance in the tumor responses between two criteria. When adopting the PERCIST, tumor response was upgraded in 85 patients and downgraded in 16. The estimated overall response rates were significantly different between two criteria (35.1% by RECIST vs. 54.1% by PERCIST, P < 0.0001). In conclusion, this pooled analysis demonstrates that the concordance of tumor responses between the RECIST and PERCIST criteria is not excellent. The PERCIST might be more suitable for assessing tumor response than the RECIST criteria.
doi:10.18632/oncotarget.8425
PMCID: PMC5053692  PMID: 27036043
RECIST 1.0; RECIST 1.1; PET; PERCIST; tumor response
24.  XXIV World Allergy Congress 2015 
Lee, Heung-Man | Park, Il-Ho | Shin, Jae-Min | Yoon, Hyun-Sun | Park, Gyeong Yul | Zeher, Margit | Matsui, Katsuhiko | Tamai, Saki | Ikeda, Reiko | Suri, Drsushil | Suri, Dranu | Arani, Marzieh Heidarzadeh | Lubis, Azwin | Endaryanto, Anang | Koga, Shinichiro | Suk, Lee Ju | Tsuzuki, Yasunobu | Kim, Seo Hyeong | Shin, Jung U. | Noh, Ji Yeon | Jin, Shan | Jin, Shan | Lee, Hemin | Lee, Jungsoo | Park, Chang Ook | Lee, Kwang Hoon | Lee, Kwang Hoon | Tepetam, Fatma Merve | Park, Chun Wook | Son, Jee Hee | Cho, Soo Ick | Cho, Yong Se | Byun, Yun Sun | Yang, Yoon Seok | Chung, Bo Young | Kim, Hye One | Cho, Hee Jin | Katada, Yoshinori | Tanaka, Toshio | Nakabayashi, Akihiko | Nishida, Koji | Aoyagi, Kenichi | Tsukamoto, Yuki | Konma, Kazushi | Matsuura, Motoo | Park, Jung-Won | Harada, Yoshinori | Jeong, Kyoung Yong | Yura, Akiko | Yoshimura, Maiko | Kyung, Tae-Suk | Kim, Young Hyo | Park, Chang-Shin | Jang, Tae Young | Heo, Min-Jeong | Jung, Ah-Yeoun | Yang, Seung-Chan | Kim, Hye One | Cho, Yong Se | Byun, Yun Sun | Yang, Yoon Seok | Chung, Bo Young | Son, Jee Hee | Park, Chun Wook | Cho, Hee Jin | Pfaar, Oliver | Sager, Angelika | Agarwal, Amit | Singh, Meenu | Chatterjee, Bishnupda | Chauhan, Anil | Striz, Ilja | Cecrdlova, Eva | Petrickova, Katerina | Kolesar, Libor | Sekerkova, Alena | Svachova, Veronika | Petricek, Miroslav | Kwon, Hyuck Hoon | Kim, Kyu Han | Kumar, Suman | Manzon, Lou Ver Leigh Arciaga | Andaya, Pilar Agnes Gonzalez | Lew, Bark-Lynn | Oh, Youngjun | Suh, Dongwoo | Sim, Woo-Young | Jeong, Kyoung Yong | Yi, Myung-Hee | Son, Mina | Lyu, Dongpyo | Lee, Jae-Hyun | Yong, Tai-Soon | Hong, Chein-Soo | Park, Jung-Won | Jeong, Kyoung Yong | Yi, Myung-Hee | Son, Mina | Lyu, Dongpyo | Lee, Jae-Hyun | Yong, Tai-Soon | Hong, Chein-Soo | Park, Jung-Won | Siavashi, Mohammadreza | Yun, Hey Suk | Kang, Ha-Na | Oh, Jae-Won | Choi, Young Jin | Oh, Jae-Won | Choi, Young Jin | Kang, Ha-Na | Sentsova, Tatiana | Vorozhko, Ilya | Chernyak, Olga | Revyakina, Vera | Timopheeva, Anna | Donnikov, Andrey | Sentsova, Tatiana | Vorozhko, Ilya | Chernyak, Olga | Revyakina, Vera | Timopheeva, Anna | Lee, Ji Hyun | Park, Young Min | Choi, Sang Soo | Han, Kyung Do | Jung, Han Mi | Youn, Young Hoon | Lee, Jun Young | Park, Yong Gyu | Lee, Seung-Hwan | Li, Jing | Feng, Mulin | Roponen, Marjut | Schaub, Bianca | Wong, Gary W. K. | Yang, Zhaowei | Choi, Young Jin | Kang, Ha-Na | Oh, Jae-Won | Sun, Baoqing | Zheng, Peiyan | Park, Yoon-Sung | Son, Sang Wook | Kose, Sukran | Kiraz, Kemal | Yalcin, Arzu Didem | Yune, Sehyo | Paeng, Jae-Won | Oh, Mi-Jung | Lee, Byung-Jae | Choi, Dong-Chull | Lim, Young Hee | Ha, Kyoung Won | Lee, Jin-Young | Yamamoto-Hanada, Kiwako | Narita, Masami | Futamura, Masaki | Ohya, Yukihiro | Kim, Jihyun | Choi, Jinwha | Kim, Kwanghoon | Choi, Jaehee | Ahn, Kangmo | Chang, Sun-Ho/Brian | Li, Lisha | Adachi, Yu-Ichi | Kanatani, Kumiko Tsuji | Narabayashi, Shigeyuki | Okafuji, Ikuo | Tanaka, Yuya | Tsuruta, Satoru | Takamatsu, Nobue | Kim, Soo Whan | Kim, Do Hyun | Yoon, Jong-Seo | Kim, Jin Tack | Kim, Hwan Soo | Chun, Yoon Hong | Kim, Hyun Hee | Won, Sul Mui | Hon, Kam Lun E. | Chow, Chung Mo | Leung, Ting Fan | Kim, Do Hyun | Kim, Soo Whan | Esguerra, Gemmalyn | Resurreccion, Emily | Kionisala, Kristine Elisa | Dela Cruz, Jenni Rose | Imran, Muhammad | Choe, Yun Seon | Kim, Kyu Han | Choi, Mira | Kim, Byung Soo | Lee, Hyun-Joo | Kim, Jeong-Min | Kim, Jeong-Min | Kim, Gun-Wook | Mun, Je-Ho | Mun, Je-Ho | Kim, Hoon-Soo | Song, Margaret | Ko, Hyun-Chang | Ko, Hyun-Chang | Kim, Moon-Bum | Yoon, Sun-Young | Kandhare, Amit | Yahiro, Noriko | Agarwal, Amit | Singh, Meenu | Kaur, Jasleen | Pawankar, Ruby | Pant, Pankaj | Singh, Sukhmanjeet | Kim, Hwan Soo | Yoon, Jong-Seo | Won, Sul Mui | Chun, Yoon Hong | Kim, Jin Tack | Kim, Hyun Hee | Kim, Hwan Soo | Won, Sul Mui | Chun, Yoon Hong | Yoon, Jong-Seo | Kim, Hyun Hee | Kim, Jin Tack | Kampitak, Thatchai | Kim, So Min | Lee, Hyun Joo | Kim, Hei Sung | Lee, Jeong Deuk | Cho, Sang Hyun | Godse, Kiran | Soekarno, Juwita | Ratnasari, Sarie | Datau, E. Alwi | Surachmanto, Eko | Matheos, JC | Leung, Ting Fan | Kwok, Jamie Sui-Lam | Tung, Christine Kit-Ching | Tang, Man Fung | Tsui, Stephen Kwok-Wing | Wong, Gary WK | Hon, Kam Lun Ellis | Tam, Wing Hung | Sy, Hing Yee | Lee, Sohee | Shin, Hyun-Woo | Lee, Mingyu | Kim, Dae Woo | Khalmuratova, Roza | Kim, Mi Yeoung | Jeong, Jaewon | Park, Chansun | Wai, Christine Yee Yan | Leung, Patrick S. C. | Leung, Nicki Y. H. | Chu, Ka Hou | Lee, Hee Seon | Lee, Kyung Eun | Hong, Jung Yeon | Kim, Mi Na | Kim, Min Jung | Kim, Yoon Hee | Sol, In Suk | Yoon, Seo Hee | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Kim, Ji Hye | Park, Hae-Sim | Shin, Yoo Seob | Ye, Young Min | Seo, Daehong | Yoon, Moon Gyeong | Lee, Young Mok | Seo, Daehong | Kim, Ji Hye | Lee, Young-Mok | Ye, Young Min | Park, Hae-Sim | Ban, Ga Young | Cho, Kumsun | Kim, Seung-Hyun | Kwon, Yong Eun | Yoon, Moon Gyeong | Kim, Ji Hye | Shin, Yoo Seob | Ye, Young Min | Nahm, Dong-Ho | Park, Hae-Sim | Andaya, Pilar Agnes Gonzalez | Andaya, Pilar Agnes Gonzalez | Ban, Ga Young | Jung, Chang Gyu | Lee, Seung-Ihm | Le Pham, Duy | Suh, Dong-Hyeon | Yang, Eun-Mi | Ye, Young Min | Shin, Yoo Seob | Park, Hae-Sim | Wang, Wan Jun | Xian, MO | Xie, Yan Qing | Zheng, Jing Ping | Li, Jing | Savilahti, Emma Merike | Mäkitie, Outi | Kukkonen, Anna Kaarina | Andersson, Sture | Viljakainen, Heli | Savilahti, Erkki | Kuitunen, Mikael | Godse, Kiran | Le Pham, Duy | Ban, Ga Young | Kim, Seung-Hyun | Yang, Eun-Mi | Park, Hae-Sim | Lee, Ji-Ho | Chwae, Yong-Joon | Chin, Li-Ming | Shieh, Chi-Chang | Kim, Ji Hye | Yoo, Hye-Soo | Yoon, Moon Gyeong | Ban, Ga Young | Ban, Ga Young | Shin, Yoo Seob | Ye, Young Min | Park, Hae-Sim | Sung, Myong Soon | Choi, Jin Uck | Kim, Sung Won | Hwang, Yong Jin | Park, Arum | Lee, Eun | Yang, Song-I | Cho, Hyun-Ju | Yu, Jinho | Lee, Dong Hun | Kim, Eun Ju | Kim, Yeon Kyung | Doh, Eun Jin | Eun, Hee Chul | Chung, Jin Ho | Lee, Young Mee | Jin, Seon Pil | Li, Xingnan | Kaminski, Naftali | Wenzel, Sally | Bleecker, Eugene | Meyers, Deborah | Huasong, Zeng | Mo, Ji-Hun | Samivel, Ramachandran | Kim, Eun-Hee | Kim, Ji-Hye | Bae, Jun-Sang | Chung, Young-Jun | Kim, Dae Woo | Lee, Eun | Lee, Si Hyeon | Kim, Young-Ho | Cho, Hyun-Ju | Yu, Ho-Sung | Kang, Mi-Jin | Yang, Song-I | Jung, Young-Ho | Kim, Hyung Young | Seo, Ju-Hee | Kim, Byoung-Ju | Kim, Hyo-Bin | Lee, So-Yeon | Kwon, Ho-Jang | Hong, Soo-Jong | Palikhe, Sailesh | Park, Hae-Sim | Kim, Seung-Hyun | Kim, Ji Hye | Yang, Eun-Mi | Sibunruang, Suda | Klaewsongkram, Jettanong | Sentsova, Tatiana | Vorozhko, Ilya | Timopheeva, Anna | Chernyak, Olga | Revyakina, Vera | Sokolnikov, Andrey | Nisihino, Makoto | Okada, Yu | Yanagida, Noriyuki | Ebisawa, Motohiro | Sato, Sakura | Ogura, Kiyotake | Asaumi, Tomoyuki | Nagakura, Kenichi | Manabe, Tetsuharu | Unno, Hirotoshi | Rodrigues, Pedro M. | Schrama, Denise | Mohamed, Gadija | Hüsselmann, Lizex | Hüsselmann, Lizex | Ndimba, Bongani | Shim, Jae-Uoong | Koh, Young Il | Rhee, Joon Haeng | Jeong, Ji-Ung | Van Nguyen, Dinh | Chu, Hieu Chi | Tran, Mui Thi | Vidal, Christopher | Fernando, Suran | Van Nunen, Sheryl | Van Than, Sy | Feng, Mulin | Li, Jing | Kim, Dong-Kyu | Hong, Seung-No | Eun, Kyoung Mi | Jin, Hong Ryul | Kim, Dae Woo | Bao, Jun | Bao, Yi-Xiao | Podder, Sanjoy | Kumar, Goutam | Dutta, Shampa | Ghosh, Amlan | Saha, Goutam Kumar | Podder, Sanjoy | Gupta, Salil Kumar | Trinh, Tu/Hoang Kim | Shin, Yoo Seob | Park, Hae-Sim | Liu, Jing-Nan | Le Pham, Duy | Ko, Hyun-Chang | Kim, Byung Soo | Kim, Moon-Bum | Özbudak, Ömer | Üzer, Fatih | Al-Ahmad, Mona | Alowayesh, Maryam | Carroll, Norman | Singh, Anand Bahadur | Pérez-Llano, Yordanis | Lorenzo, María Del Carmen Luzardo | González, Wendy Ramírez | Cruz, Carlos Calcines | Quintana, Rady Laborde | Morejón, Alain | Bourg, Virgilio | Stoker, Marilé Hechavarría | Bae, Jun-Sang | Samivel, Ramachandran | Kim, Eun-Hee | Kim, Ji-Hye | Mo, Ji-Hun | Hanaoka, Keiko | Hide, Michihiro | Tanaka, Akio | Hiragun, Makiko | Kawai, Mikio | Kim, Kwanghoon | Kim, Hye-Young | Kim, Jihyun | Ahn, Kangmo | Han, Youngshin | Kim, Gun-Wook | Ko, Hyun-Chang | Kim, Byung Soo | Kim, Moon-Bum | Song, Margaret | Matsubara, Takeshi | Iwamoto, Hiroshi | Nakazato, Yuki | Namba, Kazuyoshi | Takeda, Yasuhiro | Lee, Jae Hoon | Bae, Woo Yong | De Schryver, Els | Calus, Lien | Gevaert, Philippe | Van Zele, Thibaut | Bachert, Claus | Mori, Akio | Kouyama, Satoshi | Yamaguchi, Miyako | Iijima, Yo | Abe-Ohtomo, Akemi | Hayashi, Hiroaki | Watai, Kentaroh | Mitsui, Chihiro | Oshikata, Chiyako | Sekiya, Kiyoshi | Tsuburai, Takahiro | Ohtomo, Mamoru | Fukutomi, Yuma | Taniguchi, Masami | Kang, Ju Wan | Kim, Jeong Hong | Kim, Jeong Hong | Lee, Keun-Hwa | Lee, Hye-Sook | Hong, Seong-Chul | Lee, Jaechun | Seo, Ji Won | Lee, Jae Hoon | Bae, Woo Yong | Kuznecovs, Ivans Sergejs | Kuznecova, Galina | Bergmann, Karl-Christian | Zuberbier, Torsten | Salame, Joseph | Sehlinger, Torsten | Bölke, Georg | Kim, Yoo Suk | Chang, Jung Hyun | Kim, Jeong Hong | Kang, Ju Wan | Hong, Seung-No | Han, Doo Hee | Rhee, Chae-Seo | Ko, Young-Joo | Kim, Young Hyo | Kim, Dae-Young | Jang, Tae Young | Yokooji, Tomoharu | Hirano, Taiki | Matsuo, Hiroaki | Kuznecova, Galina | Kuznecovs, Ivans Sergejs | Wani, Roohi Rasool | Syed, Shafia Alam | Hassan, Ghulam | Gul, Ayaz | Nissar, Saniya | Shah, Zaffar Amin | Pereira, Marilyn Urrutia | Fernandez, Carmen | Sole, Dirceu | Neto, Herberto Jose Chong | Acosta, Veronica | Cepeda, Alfonso Mario | Castello, Mirta Alvarez | Almendarez, Claudia | Saenz, Jose Santos Lozano | Sisul, Juan C. | Filho, Nelson Rosario | Castillo, Antonio | Rostan, Marylin Valentin | Avila, Jennifer | Badellino, Hector | Manotas, Maria Carolina | Almarales, Raúl Lázaro Castro | León, Mayda González | Kim, Woo Kyung | Yoon, Hae-Sun | Kobayashi, Takehito | Noguchi, Tooru | Soma, Tomoyuki | Nakagome, Kazuyuki | Nakamoto, Hidetomo | Kita, Hirohito | Nagata, Makoto | Pereira, Marilyn Urrutia | Sole, Dirceu | Neto, Herberto Jose Chong | Cepeda, Alfonso Mario | Almarales, Raúl Lázaro Castro | Sisul, Juan C. | Rostan, Marylin Valentin | Badellino, Hector | Avalos, Miguel Alejandro Medina | Castillo, Antonio | Almendarez, Claudia | Filho, Nelson Rosario | Silot, Caridad Sanchez | Avila, Jennifer | Rodriguez, Felicia Berroa | Saenz, Jose Santos Lozano | Castello, Mirta Alvarez | Fernandez, Carmen | Soh, Wai Tuck | Jacquet, Alain | Ruxrungtham, Kiat | Nony, Emmanuel | Le Mignon, Maxime | Lee-Wong, Mary | McClelland, Suzanne | McClelland, Suzanne | Silverberg, Nanette B. | Song, Christian E. | Yang, Zhaowei | Zhang, Jiukai | Zheng, Wentao | Zhong, Nanshan | Li, Jing | Bae, Jung Ho | Cho, Young Joo | Kim, Joo Yeon | Vourdas, Dimitrios | Grigoreas, Christos | Petalas, Konstantinos | Zhang, Yuan | Shin, Seung-Heon | Ye, Mi-Kyung | Kim, Jeong-Kyu | Feng, Yong | Shang, Yunxiao | Seo, Sungchul | Choung, Ji Tae | Kim, Dohyeong | Yoo, Young | Lim, Hyunwook | Zhu, Wenjing | Liu, Chuanhe | Sha, Li | Chang, Li | Zhao, Min | Zhao, Linqing | Qian, Yuan | Chen, Yuzhi | Kim, Min-Hye | Cho, Young Joo | Rho, Mina | Kim, Jung-Won | Kang, Yeon-Mi | Yum, Kyung-Eun | Choi, Hyeon-Il | Choi, Jun-Pyo | Park, Han-Ki | Min, Taek-Ki | Pyun, Bok-Yang | Kim, Yoon-Keun | Wang, Xueyan | Kim, Woo Kyung | Nam, Yu Ran | Nam, Joo Hyun | Kim, Jung-Won | Kim, Min-Hye | Rho, Mina | Kang, Yeon-Mi | Yum, Kyung-Eun | Choi, Hyeon-Il | Choi, Jun-Pyo | Park, Han-Ki | Min, Taek-Ki | Cho, Young Joo | Pyun, Bok-Yang | Kim, Yoon-Keun | Narita, Hiroshi | Hirose, Junko | Kizu, Kumiko | Matsunaga, Ayu | Li, Jingyun | Zhang, Yuan | Zhang, Luo | Choi, Yean Jung | Shin, Hye Lim | Yang, Song-I | Lee, So-Yeon | Kwon, Sung-Ok | Jung, Young-Ho | Kwon, Ji-Won | Kim, Hyung Young | Seo, Ju-Hee | Kim, Byoung-Ju | Kim, Hyo-Bin | Oh, Se-Young | Kwon, Ho-Jang | Lee, Eun | Kang, Mi-Jin | Hong, Soo-Jong | Lee, Yun-Jeong | Kim, Joonil | Choi, Joon Young | Kang, Ji Young | Kim, Seok Chan | Kim, Sei Won | Kim, Seung Joon | Kim, Young Kyoon | Rhee, Chin Kook | Lee, Hea Yon | Lee, Hwa Young | Lee, Sook Young | Koh, Tae Kyung | Kim, Sung Wan | Lee, Kun Hee | Kwon, Chul | Jo, Joong-Saeng | Dong, Sung-Hwa | Byun, Young Seok | Song, Charles | Kang, Ji Young | Lee, Hwa Young | Kim, In Kyoung | Kim, Sei Won | Rhee, Chin Kook | Kim, Seung Joon | Kim, Seok Chan | Lee, Sook Young | Kim, Young Kyoon | Kwon, Soon Seog | Choi, Joon Young | Park, Pona | Jin, Hong Ryul | Kim, Dong-Kyu | Kim, Dae Woo | Hogenkamp, Astrid | Knippels, Leon | Van Esch, Betty C.a.m. | Van Bilsen, Jolanda | Jeurink, Prescilla V. | Gros, Marjan | Garssen, Johan | Smit, Joost J. | Pieters, Raymond H. H. | Kim, Boo-Young | Kim, Soo Whan | Lleonart, Ramon | Lay, Christophe | Benamor, Kaouther | Chen, Chua Mei | Knol, Jan | Chew, Charmaine | Chongsrisawat, Voranush | Goh, Anne | Chiang, Wen Chin | Rao, Rajeshwar | Chaithongwongwatthana, Surasith | Khemapech, Nipon | Yhi, Ji Young | Kim, Sang-Heon | Park, Dong Won | Moon, Ji-Yong | Kim, Tae Hyung | Sohn, Jang Won | Shin, Dong Ho | Yoon, Ho Joo | Cho, Seok Hyun | Kim, Sang-Heon | Moon, Ji-Yong | Lee, Jae-Hyun | Ban, Ga Young | Kim, Sujeong | Kim, Mi-Ae | Kim, Joo-Hee | Kim, Min-Hye | Park, Chan-Sun | Kwon, Hyouk-Soo | Kwon, Jae-Woo | Jung, Jae Woo | Kang, Hye-Ryun | Park, Jong-Sook | Kim, Tae-Bum | Park, Heung Woo | Cho, You Sook | Yoo, Kwang-Ha | Oh, Yeon-Mok | Lee, Sang-Rok | Julge, Kaja | Vasar, Maire | Vasar, Maire | Voor, Tiia | Rebane, Tiina | Kim, Yu Jin | Lee, Sang Min | Kang, Shin Myung | Kim, Sojeong | Kyung, Sun Young | Jeong, Sung Hwan | Park, Jeong-Woong | Hwang, Hyunjung | Seon, Yong Han | Park, Sanghui | Lee, Sang Pyo | Iordache, Marius | Jeong, Yeongsang | Eun, Sohee | Choi, Byung Min | Choung, Ji Tae | Seo, Wonhee | Zhang, Liang | Pawankar, Ruby | Nonaka, Manabu | Hayashi, Miyuki | Yamanishi, Shingo | Suzaki, Harumi | Itoh, Yasuhiko | Watanabe, So | Kobayashi, Hitome | Zotter, Zsuzsanna | Farkas, Henriette | Varga, Lilian | Veszeli, Nora | Imreh, Eva | Kovacs, Gabor | Nallbani, Marsel | Zheleznov, Semen | Urzhumtseva, Galina | Petrova, Natalia | Sarsaniia, Zhanna | Didkovskii, Nikolai | Zuberbier, Torsten | Gerdabi, Nader Dashti | Khodadadi, Ali | Abdoli, Zahra | Ghafourian, Mehri | Assarehzadegan, Mohammad Ali | Ghorban, Khodayar | Kim, Hyo-Bin | Zhou, Hui | Kim, Jeong Hee | Habre, Rima | Bastain, Theresa | Gilliland, Frank | Bae, Jong-Wook | Han, Kyu-Hyung | Jee, Young-Koo | Choi, Misoo | Hong, Seung-Phil | Kim, Seung-Hyun | Kim, Hee-Kyoo | Choi, Gil-Soon | Heo, Jeonghoon | Kim, Young-Ho | Park, Eun-Kee | Inoue, Takashi | Ogura, Kiyotake | Yanagida, Noriyuki | Unno, Hirotoshi | Nagakura, Kenichi | Manabe, Tetsuharu | Asaumi, Tomoyuki | Sato, Sakura | Okada, Yu | Ebisawa, Motohiro | Kim, Min-Gu | Cho, You Sook | Kim, Tae-Bum | Moon, Hee-Bom | Kim, Jung-Hyun | Kim, Hyo-Jung | Park, So-Young | Seo, Bomi | Kwon, Hyouk-Soo | Lee, Jaemoon | Lee, Taehoon | Yoo, Hye-Soo | Kim, Jieun | Kim, Inok | Kim, Haejin | Chang, Younhee | Park, Hae-Sim | Lee, Sooyoung | Lee, Sooyoung | Kuzume, Kazuyo | Koizumi, Munemitsu | Nishimura, Koji | Okamoto, Michiko | Kim, Seung-Hyun | Ye, Young Min | Hur, Gyu Young | Park, Hae-Sim | Kim, Sang-Heon | Jee, Young-Koo | Kim, Seung-Hyun | Choi, Hyunna | Ye, Young Min | Park, Hae-Sim | Van Khanh, Bui | Chu, Hieu Chi | Nguyet, Nguyen Nhu | Phuong, Nguyen Hoang | Roh, Joo Young | Kim, Hyun Jeong | Kim, Jung Eun | Lew, Bark-Lynn | Lee, Kyung Ho | Hong, Seung-Phil | Jang, Yong Hyun | Park, Kui Young | Seo, Seong Jun | Bae, Jung Min | Choi, Eung Ho | Suhr, Ki Beom | Lee, Seung Chul | Ko, Hyun-Chang | Park, Young Lip | Son, Sang Wook | Seo, Young Jun | Lee, Yang Won | Cho, Sang Hyun | Park, Chun Wook | Lee, Kun Hee | Kim, Sung Wan | Chu, Chia-Yu | Aw, Derrick | Ye, Young-Min | Bader, Giovanni | Dolfi, Fabrizio | Oliveira, Nathalie | Choi, Jae Chol | Jung, Jae Woo | Kang, Hye-Ryun | Kim, Kijeong | Choi, Byoung Whui | Shin, Jong Wook | Jung, Jae Woo | Choi, Jae Chol | Park, In Won | Choi, Byoung Whui | Kim, Jae Yeol | Lee, Jin-Young | Ha, Kyoung Won | Jeung, Yun-Jin | Yune, Sehyo | Lee, Byung-Jae | Choi, Dong-Chull | Oh, Mi-Jung | Lim, Young Hee | Lee, Eui Jun | Suh, Dongin | Suh, Dongin | Woo, Sung-Il | Woo, Sung-Il | Cho, Hwa Jin | Cho, Hwa Jin | Chung, Eun Hee | Chung, Eun Hee | Chung, Soo Youn | Shah, Ashok | Gera, Kamal | Ha, Kyoung Won | Oh, Mi-Jung | Lim, Young Hee | Yune, Sehyo | Paeng, Jae-Won | Jang, Mi-Jin | Lee, Byung-Jae | Choi, Dong-Chull | Lee, Jin-Young | Jang, Mi-Jin | Paeng, Jae-Won | Jeung, Yun-Jin | Lim, Young Hee | Oh, Mi-Jung | Ha, Kyoung Won | Lee, Byung-Jae | Choi, Dong-Chull | Yune, Sehyo | Lee, Jin-Young | Ito, Takahiro | Lee, Jin-Young | Yune, Sehyo | Lee, Byung-Jae | Choi, Dong-Chull | Jang, Mi-Jin | Paeng, Jae-Won | Kim, Young Eun | Kim, Young Nam | Lee, Yongseok | Kim, Jihye | Lee, Hwa Young | Lee, Sook Young | Kwon, Soon Seog | Kim, Young Kyoon | Rhee, Chin Kook | Kim, Sei Won | Lee, Hea Yon | Choi, Joon Young | Kim, In Kyoung | Aranzabal, Maria Ascension | Joral, Alejandro | Lizarza, Susana | Echenagusia, Miguel | Lasa, Eva Maria | Navarro, Jose Antonio | Jo, Eun-Jung | Jang, Sun-Mi | Song, Seung-Eon | Na, Hae-Jung | Kim, Chang-Hoon | Lee, Woo-Seop | Park, Hye-Kyung | Miyauchi, Sachiko | Uchida, Yoshitaka | Soma, Tomoyuki | Yamazaki, Susumu | Noguchi, Toru | Kobayashi, Takehito | Nakagome, Kazuyuki | Nagata, Makoto | Oh, Hea Lin | Kim, Do Kyun
Table of Contents
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
Jae-Min Shin, Heung-Man Lee, Il-Ho Park
A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines
Hyun-Sun Yoon, Gyeong Yul Park
A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome
Margit Zeher
A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendritic cells
Katsuhiko Matsui, Saki Tamai, Reiko Ikeda
A5 An evaluation of variousallergens in cases of allergic bronchial asthma at lucknow and neighbouring districts by intradermal skintest
Drsushil Suri, Dranu Suri
A6 Evaluation ferqency of ADHD in childhood asthma
Marzieh Heidarzadeh Arani
A7 Steven johnson syndrome caused by typhoid fever in a child
Azwin Lubis, Anang Endaryanto
A8 Chronic Bronchitis with Radio Contrast Media Hypersensitivity: A Case with Hypothesized GINA Step 1 Asthma
Shinichiro Koga
A9 The association between asthma and depression in Korean adult : An analysis of the fifth korea national health and nutrition examination survey (2010-2012)
Lee Ju Suk
A10 Management of allergic disease exacerbations in pregnancy
Yasunobu Tsuzuki
A11 Subcutaneous immunotherapy mouse model for atopic dermatitis
Seo Hyeong Kim, Jung U Shin, Ji Yeon Noh, Shan Jin, Shan Jin, Hemin Lee, Jungsoo Lee, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee
A12 Atopic disease and/or atopy are risk factors for local anesthetic allergy in patients with history of hypersensitivity reactions to drugs?
Fatma Merve Tepetam
A13 Food hypersensitivity in patients with atopic dermatitis in Korea
Chun Wook Park, Jee Hee Son, Soo Ick Cho, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Hye One Kim, Hee Jin Cho
A14 Anaphylaxis caused by an ant (Brachyponera chinensis) in Japan
Yoshinori Katada, Toshio Tanaka, Akihiko Nakabayashi, Koji Nishida, Kenichi Aoyagi, Yuki Tsukamoto, Kazushi Konma, Motoo Matsuura, Jung-Won Park, Yoshinori Harada, Kyoung Yong Jeong, Akiko Yura, Maiko Yoshimura
A15 Anti-allergic effect of anti-IL-33 by suppression of immunoglobulin light chain and inducible nitric oxide synthase
Tae-Suk Kyung, Young Hyo Kim, Chang-Shin Park, Tae Young Jang, Min-Jeong Heo, Ah-Yeoun Jung, Seung-Chan Yang
A16 Food hypersensitivity in patients with chronic urticaria in Korea
Hye One Kim, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Jee Hee Son, Chun Wook Park, Hee Jin Cho
A17 Dose optimizing study of a depigmented polymerized allergen extract of phleum pollen by means of conjunctival provocation test (CPT)
Angelika Sager, Oliver Pfaar
A18 Correlation of cutaneous sensitivity and cytokine response in children with asthma
Amit Agarwal, Meenu Singh, Bishnupda Chatterjee, Anil Chauhan
A19 Colabomycin E, a Streptomycete-Derived Secondary Metabolite, Inhibits Proinflammatory Cytokines in Human Monocytes/Macrophages
Ilja Striz, Eva Cecrdlova, Katerina Petrickova, Libor Kolesar, Alena Sekerkova, Veronika Svachova, Miroslav Petricek
A20 Intravenous immunoglobluin treatment in a child with resistant atopic dermatitis: A brief review on this therapeutic regimen
Hyuck Hoon Kwon, Kyu Han Kim
A21 Wheat allergy is difficult to diagnose then other food allergens
Suman Kumar
A22 The effects of spirulina (Arthrospira platensis) dietary supplement as an adjunct therapy for children aged 7 to 14 years old with asthma: A randomized - double blind placebo controlled clinical trial
Lou Ver Leigh Arciaga Manzon, Pilar Agnes Gonzalez Andaya
A23 The study about cause and clinicopathological findings of injection induced dermatitis
Bark-Lynn Lew, Youngjun Oh, Dongwoo Suh, Woo-Young Sim
A24 IgE reactivity of recombinant allergen pac c 3 of the Asian needle ant pachycondyla chinensis
Kyoung Yong Jeong, Myung-Hee Yi, Mina Son, Dongpyo Lyu, Jae-Hyun Lee, Tai-Soon Yong, Chein-Soo Hong, Jung-Won Park
A25 Characterization of specific IgE antibody related to antigen 5 of echinococcus granulosus
Mohammadreza Siavashi
A26 Development of binary forecast model of asthma exacerbation: Asthma index
Hey Suk Yun, Ha-Na Kang, Jae-Won Oh, Young Jin Choi
A27 Different levels in rantes, IL-5 and TNF-á between the nasal polyps of adolescents with allergic, local allergic and non-allergic rhinitis
Ha-Na Kang, Jae-Won Oh, Young Jin Choi
A28 Tgfβ1 level is associated with VDR gene polymorphism in children with allergy diseases
Tatiana Sentsova, Ilya Vorozhko, Olga Chernyak, Vera Revyakina, Anna Timopheeva, Andrey Donnikov
A29 Dynamics of immunological biomarkers in children with food allergy fed goat milk formula
Tatiana Sentsova, Ilya Vorozhko, Olga Chernyak, Vera Revyakina, Anna Timopheeva
A30 Association between obesity, abdominal obesity and adiposity and the prevalence of atopic dermatitis in young Korean adults: The korea national health and nutrition examination survey, 2008–2010
Ji Hyun Lee, Young Min Park, Sang Soo Choi, Kyung Do Han, Han Mi Jung, Young Hoon Youn, Jun Young Lee, Yong Gyu Park, Seung-Hwan Lee
A31 Associations of natural history and environmental factors with asthma among children in rural and urban areas of guangdong, China
Zhaowei Yang, Jing Li, Mulin Feng, Marjut Roponen, Bianca Schaub, Gary WK Wong
A32 The effect of CO2-enriched atmospheres to producing of allergenic pollen by ragweed
Young Jin Choi, Ha-Na Kang, Jae-Won Oh
A33 Application evaluation of house dust mite and components specific-IgE and IgG4 in specific immunotherapy with allergic diseases
Baoqing Sun, Peiyan Zheng
A34 Effect of Asian dust events on asthma according to the socioeconomic status using claim data in KOREA
Yoon-Sung Park
A35 TSLP downregulates human â-defensin 2 through STAT3-dependent pathway in keratinocytes
Sang Wook Son
A36 Effects of anti-IgE on IL-4, IL-5, IL-17, and CD19,20,200 in a case of netherton syndrome (SPINK5 mutation)
Arzu Didem Yalcin, Sukran Kose, Kemal Kiraz
A37 Augmentation of arginase 1 expression exacerbates airway inflammation in murine asthma models
Jin-Young Lee, Sehyo Yune, Jae-Won Paeng, Mi-Jung Oh, Byung-Jae Lee, Dong-Chull Choi, Young Hee Lim, Kyoung Won Ha
A38 Caregivers of children with no food allergy – their experiences and perception of the condition
Kiwako Yamamoto-Hanada, Masami Narita, Masaki Futamura, Yukihiro Ohya
A39 Evaluation of Drug Provocation Tests in Korean Children: A Single Center Experience
Jihyun Kim, Jinwha Choi, Kwanghoon Kim, Jaehee Choi, Kangmo Ahn
A40 Danyoung classification 2015 update by digital HD endoscopic evaluation
SUN-HO/Brian Chang
A41 Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy in polysensitized patients
Lisha Li
A42 Ambient desert dust and allergic symptoms: A time series analysis from a national birth cohort (JECS)
Kumiko Tsuji Kanatani, Yu-Ichi Adachi
A43 Individuals Allergic to Cow’s Milk Should be Vigilant When Consuming Beef Because It May be Injected Beef
Shigeyuki Narabayashi, Ikuo Okafuji, Yuya Tanaka, Satoru Tsuruta, Nobue Takamatsu
A44 Quality of life of chronic rhinosinusitis patients with or without nasal polyps in Korea
Soo Whan Kim, Do Hyun Kim
A45 House dust mite sensitization and exacerbation of asthma in the fall in children
Jong-Seo Yoon, Jin Tack Kim, Hwan Soo Kim, Yoon Hong Chun, Hyun Hee Kim, Sul Mui Won
A46 Evidence-based health advice for childhood eczema and household pets
Kam Lun E. Hon, Chung Mo Chow, Ting Fan Leung
A47 Relationship between allergic rhinitis and mental health in korea
Do Hyun Kim, Soo Whan Kim
A48 Oscillometric bronchodilator response in 3 to 5 years old healthy and asthmatic Filipino children
Gemmalyn Esguerra, Emily Resurreccion, Kristine Elisa Kionisala, Jenni Rose Dela Cruz
A49 The use of aeroallergen immunotherapy to treat eosinophilic esophagitis
Muhammad Imran
A50 A study of the eczema herpeticum in Korean
Yun Seon Choe, Kyu Han Kim, Mira Choi
A51 Specific sublingual immunotherapy in Korean patients with atopic dermatitis
Byung Soo Kim, Hyun-Joo Lee, Jeong-Min Kim, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Je-Ho Mun, Hoon-Soo Kim, Margaret Song, Hyun-Chang Ko, Hyun-Chang Ko, Moon-Bum Kim
A52 Association between polymorphisms in bitter taste receptors genes and clinical features in Korean asthmatics
Sun-Young Yoon
A53 Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats
Amit Kandhare
A54 A kampo formula, ogi-kenchu-to, decreases side-effects of steroid ointment for infantile atopic dermatitis: Three cases report
Noriko Yahiro
A55 To test use of jet nebulizers NE-C802 as a drug delivery system in the children with asthma
Amit Agarwal, Meenu Singh, Jasleen Kaur, Ruby Pawankar, Pankaj Pant, Sukhmanjeet Singh
A56 Immunoglobulin e to allergen components of house dust mite in Korean children with allergic disease
Hwan Soo Kim, Jong-Seo Yoon, Sul Mui Won, Yoon Hong Chun, Jin Tack Kim, Hyun Hee Kim
A57 Effectiveness of premedication and rapid desensitization in hypersensitivity to l-asparaginase
Hwan Soo Kim, Sul Mui Won, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim
A58 Angioedema with Eosinophilia: The First Report from Thailand
Thatchai Kampitak
A59 Evaluation of anti-pruritic and anti-inflammatory effects of Korean red ginseng extract on atopic dermatitis murine model
So Min Kim, Hyun Joo Lee, Hei Sung Kim, Jeong Deuk Lee, Sang Hyun Cho
A60 Subcutaneous autologous serum therapy in chronic urticaria
Kiran Godse
A61 Allergic bronchopulmonary aspergillosis in asthma and lung tuberculosis
Juwita Soekarno, Sarie Ratnasari, E. Alwi Datau, Eko Surachmanto, JC Matheos
A62 Infantile eczema is associated with campylobacter and roseburia subpopulations but not microbial diversity in stool samples of Chinese newborns
Ting Fan Leung, Jamie Sui-Lam Kwok, Christine Kit-Ching Tung, Man Fung Tang, Stephen Kwok-Wing Tsui, Gary WK Wong, Kam Lun Ellis Hon, Wing Hung Tam, Hing Yee Sy
A63 Association between serum chitinase level and toll-like receptor polymorphisms in bakery workers
Sohee Lee
A64 IFN-gamma contributes to nasal polypogenesis by inducing epithelial-to-mesenchymal transition via non-smad pathway
Hyun-Woo Shin, Mingyu Lee, Dae Woo Kim, Roza Khalmuratova
A65 Management and education status of anaphylaxis patients who visit our emergency room (ER)
Mi Yeoung Kim, Jaewon Jeong, Chansun Park
A66 Hypoallergen-Encoding DNA Plasmids As Immunoprophylactic Vaccines of Shrimp Tropomyosin Hypersensitivity
Christine Yee Yan Wai, Patrick S.C. Leung, Nicki Y.H. Leung, Ka Hou Chu
A67 The relationship between sputum pentraxin 3 levels and childhood asthma
Hee Seon Lee, Kyung Eun Lee, Jung Yeon Hong, Mi Na Kim, Min Jung Kim, Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim
A68 The role of local antibody responses in the nasal inflammation of allergic rhinitis (AR) patients
Ji Hye Kim, Hae-Sim Park, Yoo Seob Shin, Young Min Ye, Daehong Seo, Moon Gyeong Yoon, Young Mok Lee
A69 A case of ofloxacin-induced anaphylaxis by non-IgE, but specific IgG4-mediated responses
Daehong Seo, Ji Hye Kim, Young-Mok Lee, Young Min Ye, Hae-Sim Park
A70 Serum LTE4 metabolite as a biomarker for aspirin exacerbated respiratory disease
Ga Young Ban, Kumsun Cho, Seung-Hyun Kim, Yong Eun Kwon, Moon Gyeong Yoon, Ji Hye Kim, Yoo Seob Shin, Young Min Ye, Dong-Ho Nahm, Hae-Sim Park
A71 Local and systemic reactions of dust mite subcutaneous immunotherapy (SCIT) among children in a tertiary care hospital
Pilar Agnes Gonzalez Andaya
A72 Effects of carboxymethyl glucan (CM-glucan) in children with allergic rhinitis and asthma: A randomized controlled trial
Pilar Agnes Gonzalez Andaya
A73 Autophagy mechanisms in patients with severe asthma: A new therapeutic target
Ga Young Ban, Chang Gyu Jung, Seung-Ihm Lee, Duy Le Pham, Dong-Hyeon Suh, Eun-Mi Yang, Young Min Ye, Yoo Seob Shin, Hae-Sim Park
A74 Aggravation of airway inflammation and hypperresponsiveness following nasal challenge with dermatophagoides pteronyssinus in perennial allergic rhinitis patients without symptoms of asthma
Wan Jun Wang, MO Xian, Yan Qing Xie, Jing Ping Zheng, Jing Li
A75 Serum 25-hydroxyvitamin d in early childhood is non-linearly associated with allergy
Emma Merike Savilahti, Outi Mäkitie, Anna Kaarina Kukkonen, Sture Andersson, Heli Viljakainen, Erkki Savilahti, Mikael Kuitunen
A76 Fric test in dermographism
Kiran Godse
A77 Neutrophil autophagy and extracellular trap could contribute to asthma severity
Duy Le Pham, Ga Young Ban, Seung-Hyun Kim, Eun-Mi Yang, Hae-Sim Park, Ji-Ho Lee, Yong-Joon Chwae
A78 Redox Modulation for the Treatment of Toluene Diisocyanates-Induced Lung Inflammation
Li-Ming Chin, Chi-Chang Shieh
A79 A case of occupational asthma and rhinitis with anaphylaxis to Korean ginseng and sanyak
Ji Hye Kim, Hye-Soo Yoo, Moon Gyeong Yoon, Ga Young Ban, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Hae-Sim Park
A80 Factors of influencing epidermal permeability barrier defects in atopic dermatitis children
Myong Soon Sung, Jin Uck Choi, Sung Won Kim, Yong Jin Hwang
A81 Innate type 2 response to aspergillusfumigatus in a murine model of atopic dermatitis-like skin inflammation
Arum Park, Eun Lee, Song-I Yang, Hyun-Ju Cho, Jinho Yu
A82 Activin a receptor 1C may implicate in the development of sensitive skin
Dong Hun Lee, Eun Ju Kim, Yeon Kyung Kim, Eun Jin Doh, Hee Chul Eun, Jin Ho Chung, Young Mee Lee, Seon Pil Jin
A83 Genetic association and eQTL analyses of genes associated with allergy in atopic/non-atopic asthma
Xingnan Li, Naftali Kaminski, Sally Wenzel, Eugene Bleecker, Deborah Meyers
A84 Gastroscope feature and clinical characteristics in 172 cases of children with henoch-schonlein purpura
Zeng Huasong
A85 The role of TRPV1 in CD4+ t cell mediated inflammatory response of allergic rhinitis
Ji-Hun Mo, Ramachandran Samivel, Eun-Hee Kim, Ji-Hye Kim, Jun-Sang Bae, Young-Jun Chung, Dae Woo Kim
A86 A Phenotype of Rhinitis from School Children Is Associated with the Development of Bronchial Hyperresponsiveness
Eun Lee, Si Hyeon Lee, Young-Ho Kim, Hyun-Ju Cho, Ho-Sung Yu, Mi-Jin Kang, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, So-Yeon Lee, Ho-Jang Kwon, Soo-Jong Hong
A87 Increased basal activation status was noted in adult anaphylaxis patients
Sailesh Palikhe, Hae-Sim Park, Seung-Hyun Kim, Ji Hye Kim, Eun-Mi Yang
A88 Clinical values of interferon-gamma enzyme-linked immunospot assays for management of antibiotic hypersensitivity in hospitalized patients
Suda Sibunruang, Jettanong Klaewsongkram
A89 VDR gene polymorphism and 25-hydroxy vitamin d levels in children with food allergy
Tatiana Sentsova, Ilya Vorozhko, Anna Timopheeva, Olga Chernyak, Vera Revyakina, Andrey Sokolnikov
A90 An analysis of 145 oral almond challenge tests
Makoto Nisihino, Yu Okada, Noriyuki Yanagida, Motohiro Ebisawa, Sakura Sato, Kiyotake Ogura, Tomoyuki Asaumi, Kenichi Nagakura, Tetsuharu Manabe, Hirotoshi Unno
A91 Effect of creatine supplementation in fish allergenic potential; A proteomics study
Pedro M Rodrigues, Denise Schrama, Gadija Mohamed, Lizex Hüsselmann, Lizex Hüsselmann, Bongani Ndimba
A92 Flagellin modulates the function of invariant NKT cells via dendritic cells in asthma patients
Jae-Uoong Shim, Young Il Koh, Joon Haeng Rhee, Ji-Ung Jeong
A93 Clinical and subclinical manifestations of allopurinol – induced severe cutaneous adverse reactions in Vietnam
Dinh Van Nguyen, Hieu Chi Chu, Mui Thi Tran, Christopher Vidal, Suran Fernando, Sheryl Van Nunen, Sy Van Than
A94 Time course of serum inhibitory activity for facilitated allergen-IgE binding during house dust mite immunotherapy
Mulin Feng, Jing Li
A95 Periostin is a novel biomarker in eosinophilic nasal polyps of chronic rhinosinusitis
Dong-Kyu Kim, Seung-No Hong, Kyoung Mi Eun, Hong Ryul Jin, Dae Woo Kim
A96 Dominance of Th1-response in children with refractory mycoplasma pneumoniae pneumonia
Jun Bao, Yi-Xiao Bao
A97 Studies on the role of CD14 polymorphism among pollen and mold induced asthmatics of kolkata, India
Sanjoy Podder, Goutam Kumar, Shampa Dutta, Amlan Ghosh
A98 House dust mite allergy – Indian perspective
Goutam Kumar Saha, Sanjoy Podder, Salil Kumar Gupta
A99 Increased expression of purinergic (P2Y12) receptor and cysteinyl leukotriene receptors in the lung tissue of a mouse model of allergic asthma
Tu/Hoang Kim Trinh, Yoo Seob Shin, Hae-Sim Park, Jing-Nan Liu, Duy Le Pham
A100 Autologous serum skin test in chronic idiopathic urticaria - relationship with autoimmune markers and disease severity
Hyun-Chang Ko, Byung Soo Kim, Moon-Bum Kim
A101 Anxiety and depression levels in severe asthma patients treated with omalizumab
Ömer Özbudak, Fatih Üzer
A102 Economic burden of refractory chronic spontaneous urticaria on Kuwait health system
Mona Al-Ahmad, Maryam Alowayesh, Norman Carroll
A103 IgE-mediated maize allergy in India: A 28 kd protein responsible for food-induced allergic reaction
Anand Bahadur Singh
A104 Liposomal encapsulation of house dust mite allergens and dexamethasone modulates allergic response in a murine model of asthma
Yordanis Pérez-Llano, María Del Carmen Luzardo Lorenzo, Wendy Ramírez González, Carlos Calcines Cruz, Rady Laborde Quintana, Alain Morejón, Virgilio Bourg, Marilé Hechavarría Stoker
A105 Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells for Eosinophilic Rhinosinusitis with Nasal Polyps in a Mouse Model
Jun-Sang Bae, Ramachandran Samivel, Eun-Hee Kim, Ji-Hye Kim, Ji-Hun Mo
A106 Second line treatments of dermographic urticaria refractory to antihistamines
Keiko Hanaoka, Michihiro Hide, Akio Tanaka, Makiko Hiragun, Mikio Kawai
A107 Diagnostic Value of Specific IgE to Peanut and Ara h 2 in Korean Children with Peanut Allergy
Kwanghoon Kim, Kwanghoon Kim, Hye-Young Kim, Jihyun Kim, Kangmo Ahn, Youngshin Han
A108 Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema
Gun-Wook Kim, Hyun-Chang Ko, Byung Soo Kim, Moon-Bum Kim, Margaret Song
A109 Identification of an IgG1-mediated anaphylaxis marker and its application in evaluating the antigenicity of infant formulas
Takeshi Matsubara, Hiroshi Iwamoto, Yuki Nakazato, Kazuyoshi Namba, Yasuhiro Takeda
A110 Nitric oxide as a screening tool for evaluation of postoperative state of chronic rhinosinusitis
Jae Hoon Lee, Woo Yong Bae
A111 Comparison of different medical treatment options for crswnp: Doxycycline, methylprednisolone, mepolizumab, omalizumab
Els De Schryver, Lien Calus, Philippe Gevaert, Thibaut Van Zele, Claus Bachert
A112 Successful treatment of steroid resistant asthma model by blocking CD28 signal
Akio Mori, Satoshi Kouyama, Miyako Yamaguchi, Yo Iijima, Akemi Abe-Ohtomo, Hiroaki Hayashi, Kentaroh Watai, Chihiro Mitsui, Chiyako Oshikata, Kiyoshi Sekiya, Takahiro Tsuburai, Mamoru Ohtomo, Yuma Fukutomi, Masami Taniguchi
A113 Serum periostin levels was not associated with allergic rhinitis and allergic sensitization in Korean children
Ju Wan Kang, Jeong Hong Kim, Jeong Hong Kim, Keun-Hwa Lee, Hye-Sook Lee, Seong-Chul Hong, Jaechun Lee
A114 Roles of ADAM10 and ADAM17 in allergic rhinitis
Ji Won Seo, Jae Hoon Lee, Woo Yong Bae
A115 Mechanism of oral and topical polyprenol action in atopic dermatitis
Ivans Sergejs Kuznecovs, Galina Kuznecova
A116 Technical and clinical validation of a mobile chamber for allergen exposure tests
Karl-Christian Bergmann, Torsten Zuberbier, Joseph Salame, Torsten Sehlinger, Georg Bölke
A117 The association between serum lead level and total immunoglobulin e according to allergic sensitization
Yoo Suk Kim, Jung Hyun Chang, Jeong Hong Kim, Ju Wan Kang
A118 Clinical and laboratory characteristics of nasal obstruction dominant allergic sensitization
Seung-No Hong, Doo Hee Han, Chae-Seo Rhee
A119 Nasal provocation test is useful for the diagnoses of allergic, non- allergic, and local allergic rhinitis
Young-Joo Ko, Young Hyo Kim, Dae-Young Kim, Tae Young Jang
A120 Aspirin facilitates the intestinal absorption and oral sensitization of food allergens in rats
Tomoharu Yokooji, Taiki Hirano, Hiroaki Matsuo
A121 Gestational Secondhand Smoke Exposure Could Affect Maternal n-Glycosylation and Cause Filaggrin Loss in Children with Atopic Dermatitis
Galina Kuznecova, Ivans Sergejs Kuznecovs
A122 Allergen specific immunotherapy in the treatment of allergic rhinitis and asthma--a randomized prospective study from kashmir valley-north of India
Roohi Rasool Wani, Shafia Alam Syed, Ghulam Hassan, Ayaz Gul, Saniya Nissar, Zaffar Amin Shah
A123 Sleep disorders in latin-American children with asthma and/or allergic rhinitis and normal controls
Marilyn Urrutia Pereira, Carmen Fernandez, Dirceu Sole, Herberto Jose Chong Neto, Veronica Acosta, Alfonso Mario Cepeda, Mirta Alvarez Castello, Claudia Almendarez, Jose Santos Lozano Saenz, Juan C. Sisul, Nelson Rosario Filho, Antonio Castillo, Marylin Valentin Rostan, Jennifer Avila, Hector Badellino, Maria Carolina Manotas, Raúl Lázaro Castro Almarales, Mayda González León
A124 Association between respiratory symptoms and exhaled nitric oxide in Afghanistan
Woo Kyung Kim, Hae-Sun Yoon
A125 ATP, a danger signal, activates human eosinophils via P2 purinergic receptors
Takehito Kobayashi, Tooru Noguchi, Tomoyuki Soma, Kazuyuki Nakagome, Hidetomo Nakamoto, Hirohito Kita, Makoto Nagata
A126 Atopic dermatitis and sleep disorders in latin American children
Marilyn Urrutia Pereira, Dirceu Sole, Herberto Jose Chong Neto, Alfonso Mario Cepeda, Raúl Lázaro Castro Almarales, Juan C. Sisul, Marylin Valentin Rostan, Hector Badellino, Miguel Alejandro Medina Avalos, Antonio Castillo, Claudia Almendarez, Nelson Rosario Filho, Caridad Sanchez Silot, Jennifer Avila, Felicia Berroa Rodriguez, Jose Santos Lozano Saenz, Mirta Alvarez Castello, Carmen Fernandez
A127 Der p 23: A Major House Dust Mite Allergen in Spite of Limited Release from Fecal Pellets and Prominent Protease Sensitivity
Wai Tuck Soh, Alain Jacquet, Kiat Ruxrungtham, Emmanuel Nony, Maxime Le Mignon
A128 Anaphylactic Reaction After Inhalation of Budesonide
Mary Lee-Wong, Suzanne McClelland, Suzanne McClelland, Nanette B. Silverberg, Christian E. Song
A129 Lipidomic analysis of mattress dust from urban and rural schoolchildren in China
Zhaowei Yang, Jiukai Zhang, Wentao Zheng, Nanshan Zhong, Jing Li
A130 Improvements in quality of life in children with allergic rhinitis after adenotonsillectomy
Jung Ho Bae, Young Joo Cho, Joo Yeon Kim
A131 The seasonal variation of asthma exacerbations in patients allergic to pollens in Greece
Konstantinos Petalas, Dimitrios Vourdas, Christos Grigoreas
A132 Whole-genome sequencing study in allergic rhinitis nuclear families
Yuan Zhang
A133 Effect of the production of extracellular matrix from nasal fibroblasts by eosinophils activated with airborne fungi
Seung-Heon Shin, Mi-Kyung Ye, Jeong-Kyu Kim
A134 The study of clinical characteristics, lung function and bronchodilator responsiveness in infants with RSV bronchiolitis
Yong Feng, Yunxiao Shang
A135 GIS-based association between PM10 and allergic diseases in seoul: Implication for health and environmental policy
Sungchul Seo, Ji Tae Choung, Dohyeong Kim, Young Yoo, Hyunwook Lim
A136 The relationship between rhinovirus and recurrent wheezing
Wenjing Zhu, Chuanhe Liu, Li Sha, Li Chang, Min Zhao, Linqing Zhao, Yuan Qian, Yuzhi Chen
A137 Dominancy of Staphylcoccus Aureus in the Skin of Atopic Dermatitis Patients Compared to Healthy Subjects through Metagenomic Analysis
Min-Hye Kim, Young Joo Cho, Mina Rho, Jung-Won Kim, Yeon-Mi Kang, Kyung-Eun Yum, Hyeon-Il Choi, Jun-Pyo Choi, Han-Ki Park, Taek-Ki Min, Bok-Yang Pyun, Yoon-Keun Kim
A138 Micronized Cellulose Powder Reduces the Dose of Locally Applied Glucocorticoids in Patients with Allergic Rhinitis
Xueyan Wang
A139 New strategy for atopic dermatitis therapy with modulation of calcium ion channels
Woo Kyung Kim, Yu Ran Nam, Joo Hyun Nam
A140 Difference in the Systemic Bacterial Composition of Atopic Dermatitis Patients Compared to Healthy Subjects through Metagenomic Analysis of Urine
Jung-Won Kim, Min-Hye Kim, Mina Rho, Yeon-Mi Kang, Kyung-Eun Yum, Hyeon-Il Choi, Jun-Pyo Choi, Han-Ki Park, Taek-Ki Min, Young Joo Cho, Bok-Yang Pyun, Yoon-Keun Kim
A141 Occurrence and physiological function of immune complexes of food proteins and IgA in human saliva
Hiroshi Narita, Junko Hirose, Kumiko Kizu, Ayu Matsunaga
A142 Association between DNA hypomethylation at IL13 gene and allergic rhinitis in house dust mite-sensitized subjects
Jingyun Li, Yuan Zhang, Luo Zhang
A143 Effect of dietary methyl donors on asthma and atopy is modified by MTHFR polymorphism
Yean Jung Choi, Hye Lim Shin, Song-I Yang, So-Yeon Lee, Sung-Ok Kwon, Young-Ho Jung, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, Se-Young Oh, Ho-Jang Kwon, Eun Lee, Mi-Jin Kang, Soo-Jong Hong, Yun-Jeong Lee, Joonil Kim
A144 The effect of TSLP in a murine model of allergic asthma
Joon Young Choi, Ji Young Kang, Seok Chan Kim, Sei Won Kim, Seung Joon Kim, Young Kyoon Kim, Chin Kook Rhee, Hea Yon Lee, Hwa Young Lee, Sook Young Lee
A145 Evaluation of Aspirin Hypersensitivity in Chronic Rhinosinusitis Patients
Tae Kyung Koh, Sung Wan Kim, Kun Hee Lee, Chul Kwon, Joong-Saeng Jo, Sung-Hwa Dong, Young Seok Byun
A146 Chronic cough without wheezing in young children as a manifestation of chronic sinusitis
Charles Song
A147 Expression of muscarinic receptors and effect of tiotropium bromide on chronic asthma according to age in a murine model
Ji Young Kang, Hwa Young Lee, In Kyoung Kim, Sei Won Kim, Chin Kook Rhee, Seung Joon Kim, Seok Chan Kim, Sook Young Lee, Young Kyoon Kim, Soon Seog Kwon, Joon Young Choi
A148 Discrimination between non-eosinophilic and eosinophilic chronic rhinosinusitis with nasal polyps
Pona Park, Hong Ryul Jin, Dong-Kyu Kim, Dae Woo Kim
A149 Significant reduction in allergic features in the offspring of mice supplemented with specific non-digestible oligosaccharides during lactation
Astrid Hogenkamp
A150 Allergenicity assessment of hydrolysed infant formula; A multicenter comparison of a mouse model and a Guinea pig model for cow’s milk allergy
Leon Knippels, Betty C.a.m. Van Esch, Jolanda Van Bilsen, Prescilla V. Jeurink; Marjan Gros, Johan Garssen, Joost J Smit, Raymond H.H. Pieters
A151 Clinical significance between the allergic test and serum eosinophil cationic protein
Boo-Young Kim, Soo Whan Kim
A152 Hydroclorothiazide-induced acute non-cardiogenic pulmonary edema
Ramon Lleonart
A153 A Synbiotic Mixture of Scgos/Lcfos and Bifidobacterium Breve M-16V Is Able to Restore the Delayed Colonization of Bifidobacterium Observed in C-Section Delivered Infants
Christophe Lay, Kaouther Benamor, Chua Mei Chen, Jan Knol, Charmaine Chew, Voranush Chongsrisawat, Anne Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech
A154 Atopic characteristics of patients with asthma-COPD overlap syndrome
Ji Young Yhi, Sang-Heon Kim, Dong Won Park, Ji-Yong Moon, Tae Hyung Kim, Jang Won Sohn, Dong Ho Shin, Ho Joo Yoon, Seok Hyun Cho
A155 Perceptions and practices of severe asthma and asthma-COPD overlap syndrome among specialists: A questionnaire survey
Sang-Heon Kim, Ji-Yong Moon, Jae-Hyun Lee, Ga Young Ban, Sujeong Kim, Mi-Ae Kim, Joo-Hee Kim, Min-Hye Kim, Chan-Sun Park, Hyouk-Soo Kwon, Jae-Woo Kwon, Jae Woo Jung, Hye-Ryun Kang, Jong-Sook Park, Tae-Bum Kim, Heung Woo Park, You Sook Cho, Kwang-Ha Yoo, Yeon-Mok Oh
A156 A case of surgical diagnosed eosinophilic enteritis with intussusception in adult patient
Sang-Rok Lee
A157 Reference values of total IgE in estonian children
Kaja Julge, Maire Vasar, Tiia Voor, Tiina Rebane
A158 A case of eosinophilic granulomatosis with polyangiitis accompanied by rapidly progressive glomerulonephritis
Yu Jin Kim, Sang Min Lee, Shin Myung Kang, Sojeong Kim, Sun Young Kyung, Sung Hwan Jeong, Jeong-Woong Park, Hyunjung Hwang, Yong Han Seon, Sanghui Park, Sang Pyo Lee
A159 Associations Between Infectious Diseases and Urticaria
Marius Iordache
A160 Sleep in infants in korea – finding of bisq survey
Yeongsang Jeong, Sohee Eun, Byung Min Choi, Ji Tae Choung, Wonhee Seo
A161 Increased Expression of Filaggrin, TSLP, Periostin, IL13 and IL-33 in Nasal Polyps
Liang Zhang, Ruby Pawankar, Manabu Nonaka, Miyuki Hayashi, Shingo Yamanishi, Harumi Suzaki, Yasuhiko Itoh, So Watanabe, Hitome Kobayashi
A162 Asymptomatic bacteruria increases the risk of edematous attacks in patients with hereditary angioedema due to C1 inhibitor deficency (C1-INH-HAE)
Zsuzsanna Zotter, Henriette Farkas, Lilian Varga, Nora Veszeli, Eva Imreh, Gabor Kovacs, Marsel Nallbani
A163 Gastric Erosions Cause Spontaneous Urticaria Independent of Helicobacter Pylori
Semen Zheleznov, Galina Urzhumtseva, Natalia Petrova, Zhanna Sarsaniia, Nikolai Didkovskii, Torsten Zuberbier
A164 The Effect of G2 Vaccine on the Gene Expression NKG2D and Receptor Presenting on the Surface of NK Cells in Peripheral Blood
Nader Dashti Gerdabi, Ali Khodadadi, Zahra Abdoli, Mehri Ghafourian, Mohammad Ali Assarehzadegan, Khodayar Ghorban
A165 Ethnic differences in lifetime prevalence and indoor environmental factors for childhood eczema
Hyo-Bin Kim, Hui Zhou, Jeong Hee Kim, Rima Habre, Theresa Bastain, Frank Gilliland
A166 A case of methazolamide-induced toxic epidermal necrolysis
Jong-Wook Bae, Kyu-Hyung Han, Young-Koo Jee, Misoo Choi, Seung-Phil Hong, Seung-Hyun Kim
A167 Inflammatory responses of human adipose-tissue derived stem cells to LPS and nanoparticles
Hee-Kyoo Kim, Gil-Soon Choi, Jeonghoon Heo, Young-Ho Kim, Eun-Kee Park
A168 Analysis of 71 Cashew Nut Oral Challenge Tests
Takashi Inoue, Kiyotake Ogura, Noriyuki Yanagida, Hirotoshi Unno, Kenichi Nagakura, Tetsuharu Manabe, Tomoyuki Asaumi, Sakura Sato, Yu Okada, Motohiro Ebisawa
A169 Fungal sensitization is associated with asthma exacerbation
Min-Gu Kim, You Sook Cho, Tae-Bum Kim, Hee-Bom Moon, Jung-Hyun Kim, Hyo-Jung Kim, So-Young Park, Bomi Seo, Hyouk-Soo Kwon, Jaemoon Lee, Taehoon Lee
A170 Individual therapeutic patient education and consultation in children with atopic dermatitis
Hye-Soo Yoo, Jieun Kim, Inok Kim, Haejin Kim, Younhee Chang, Hae-Sim Park, Sooyoung Lee
A171 Utility of Alpha-Lactalbumin Specific IgE Levels Using Immulite 2000 3gAllergy in Predicting Clinical Severity of Milk Allergy
Kazuyo Kuzume, Munemitsu Koizumi, Koji Nishimura, Michiko Okamoto
A172 Isoniazid/rifampicin-specific t-cell responses in patients with anti-tuberculosis –induced dress syndrome
Seung-Hyun Kim, Young Min Ye, Gyu Young Hur, Hae-Sim Park, Sang-Heon Kim, Young-Koo Jee
A173 Genetic biomarkers associated with aspirin-exacerbated respiratory disease (AERD) phenotype based on genome-wide association study
Seung-Hyun Kim, Hyunna Choi, Young Min Ye, Hae-Sim Park
A174 Assessment of ORAL drug provocation test in the diagnosis of NON-steroidal ANTI-inflammatory drugs hypersensitivity
Bui VAN Khanh, Hieu Chi Chu, Nguyen Nhu Nguyet, Nguyen Hoang Phuong
A175 Korean treatment guideline of atopic dermatitis
Joo Young Roh, Hyun Jeong Kim, Jung Eun Kim, Bark-Lynn Lew, Kyung Ho Lee, Seung-Phil Hong, Yong Hyun Jang, Kui Young Park, Seong Jun Seo, Jung Min Bae, Eung Ho Choi, Ki Beom Suhr, Seung Chul Lee, Hyun-Chang Ko, Young Lip Park, Sang Wook Son, Young Jun Seo, Yang Won Lee, Sang Hyun Cho, Chun Wook Park
A176 Systemic side reaction of subcutaneous immunotherapy(SCIT) for perennial allergic rhinitis
Kun Hee Lee, Sung Wan Kim
A177 Clinical baseline characteristics of Asian patients suffering from refractory chronic spontaneous urticaria (CSU) in three phase 3 omalizumab clinical trials
Chia-Yu CHU, Derrick Aw, Young-Min Ye, Giovanni Bader, Fabrizio Dolfi, Nathalie Oliveira
A178 A metagenomic approach through t-RFLP to the microbiome of asthma
Jae Chol Choi, Jae Woo Jung, Hye-Ryun Kang, Kijeong Kim, Byoung Whui Choi
A179 Clinical characteristics and ten-year trend of peripheral blood eosinophilia among health screening program recipients at a tertiary hospital of South Korea
Jong Wook Shin, Jae Woo Jung, Jae Chol Choi, In Won Park, Byoung Whui Choi, Jae Yeol Kim
A180 The prevalence of toxocariasis and diagnostic value of serologic tests in asymptomatic Korean adults
Jin-Young Lee, Kyoung Won Ha, Yun-Jin Jeung, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi, Mi-Jung Oh, Young Hee Lim
A181 Cutaneous Drug Hypersensitivity Reaction in Korean Children: An Analysis of KAERS Database on 2012-2013
Eui Jun Lee, Dongin Suh, Sung-Il Woo, Hwa Jin Cho, Eun Hee Chung, Soo Youn Chung
A182 Comparison of clinical characteristics, quality of life and sleep in patients with allergic rhinitis when categorised as “sneezers and runners” and “blockers”
Kamal Gera, Ashok Shah
A183 Role of s-nitrosoglutathione reductase (GSNOR) in the murine strain differences of airway hyperresponsiveness
Jin-Young Lee, Kyoung Won Ha, Mi-Jung Oh, Young Hee Lim, Sehyo Yune, Jae-Won Paeng, Mi-Jin Jang, Byung-Jae Lee, Dong-Chull Choi
A184 Protection from airway bronchoconstriction by gsno
Jin-Young Lee, Mi-Jin Jang, Jae-Won Paeng, Yun-Jin Jeung, Young Hee Lim, Mi-Jung Oh, Kyoung Won Ha, Byung-Jae Lee, Dong-Chull Choi, Sehyo Yune
A185 Does EIA-targeted asthma treatment improve daily physical activity of children?
Takahiro Ito
A186 Wheezing as a clue to the diagnosis of cough variant asthma and nonasthmatic eosinophilic bronchitis
Jihye Kim, Jin-Young Lee, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi, Mi-Jin Jang, Jae-Won Paeng, Young Eun Kim, Young Nam Kim, Yongseok Lee
A187 Antagonism of microRNA-21 suppressed the airway inflammation in a mouse model of bronchial asthma
Hwa Young Lee, Sook Young Lee, Soon Seog Kwon, Young Kyoon Kim, Chin Kook Rhee, Sei Won Kim, Hea Yon Lee, Joon Young Choi, In Kyoung Kim
A188 Chlorhexidine anaphylaxis: A report of two cases
Jose Antonio Navarro, Maria Ascension Aranzabal, Alejandro Joral, Susana Lizarza, Miguel Echenagusia, EVA Maria Lasa
A189 Effects of Particulate Matter on Respiratory Allergic Diseases Considering Meteorological Factors in Busan, Korea
Eun-Jung Jo, Sun-Mi Jang, Seung-Eon Song, Hae-Jung Na, Chang-Hoon Kim, Woo-Seop Lee, Hye-Kyung Park
A190 Clinical characteristics of neutrophilic asthma
Sachiko Miyauchi, Yoshitaka Uchida, Tomoyuki Soma, Susumu Yamazaki, Toru Noguchi, Takehito Kobayashi, Kazuyuki Nakagome, Makoto Nagata
A191 Current Practice of Infants and Children with Acute Urticaria at a Single Wide Regional Emergency Medical Center
Hea Lin Oh, Do Kyun Kim, Dongin Suh, Young Yull Koh
A192 Discordance between sputum eosinophilia and exhaled nitric oxide
Sehyo Yune, Jin-Young Lee, Byung-Jae Lee, Dong-Chull Choi, Jae-Won Paeng, Mi-Jin Jang, Jihye Kim, Young Nam Kim
A193 Association between genetic polymorphisms of costimulatory molecules and antituberculosis drugs induced hepatitis
Sang-Heon Kim, Sang-Hoon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Jae Hyung Lee, Byoung Hoon Lee, Youn-Seup Kim, Jae-Seuk Park, Young-Koo Jee
A194 The prevalence of gastroesophageal reflux disease in chronic unexplained cough
Sehyo Yune, Jin-Young Lee, Jae-Won Paeng, Mi-Jin Jang, Dong-Chull Choi, Byung-Jae Lee, Yongseok Lee, Young Eun Kim
A195 Risk Factors of Allergic Rhinitis in Preschool Children and Clinical Utility of Feno
Jisun Yoon
A196 Relationship between serum 25-hydroxyvitamin d and asthma exacerbation severity in children
Yong Feng, Li Zhang, Xuxu Cai
A197 Usefulness of Specific IgE Antibody Levels to Wheat, Gluten and Ï-5 Gliadin for Wheat Allergy in Korean Children
Jong-Seo Yoon, Kyunguk Jeong, Hye-Soo Yoo, Sooyoung Lee, Sooyoung Lee
A198 Neutralization of stratum corneum accelerates the progress from atopic dermatitis to asthma-like lesion in flaky tail mice treated by house dust mite allergen
Hae-Jin Lee, Noo Ri Lee, Bo-Kyung Kim, Minyoung Jung, Dong Hye Kim, Catharina S. Moniaga, Kenji Kabashima, Eung Ho Choi
A199 Trends in oral food challenges in Japan: A six-year prospective study
Noriyuki Yanagida, Sakura Sato, Chizuko Sugizaki, Motohiro Ebisawa
A200 The Gut Microbiome in the Food Allergic Host
Jamie Kiehm, Punita Ponda, Sherry Farzan, Jared Weiss, Claudia Elera, Catherine Destio, Cristina Sison, Annette Lee
A201 Cord blood cytokines and maternal environmental exposure during pregnancy
Soo Hyun Ri, Chang Hoon Lim
A202 Rupatadine pharmacokinetics in Japanese healthy volunteers after single and repeated oral doses of 10, 20 and 40 mg
Iñaki Izquierdo Pulido, Jorg Taubel, Georg Ferber, Eva Santamaria Masdeu
A203 A safe and effective method to desensitize patients with wheat allergy
Alireza Khayatzadeh, Masoud Movahedi, Motohiro Ebisawa, Mohammad Gharagozlou
A204 RNA Binding Protein Hur Regulates CD4+ T Cell Differentiation and Is Required for Allergic Airway Inflammation and Normal IL-2 Homeostasis
Ulus Atasoy, Patsharaporn Techasintana, Matt Gubin, Jacqueline Glascock, Suzanne Ridenhour, Joseph Magee
A205 Time Trends in the Epidemiology of Recurrent Wheezing in Infants from South America
Nelson Rosario Filho; Herberto Jose Chong Neto, Gustavo Falbo Wandalsen, Ana Caroline Dela Bianca, Carolina Aranda, Dirceu Sole, Javier Mallol, Luis Garcia-Marcos, Luis Garcia-Marcos
A206 Successful Cyclophosphamide Desensitization in a Pediatric Patient with Systemic Lupus Erythematosus
Jennifer Toh, Yoomie Lee, Joyce Huang, Elina Jerschow, Jenny Shliozberg
A207 The Fatty Acid Binding Protein Der p 13 Is a Minor House Dust Mite Allergen Able to Activate Innate Immunity
Pattraporn Satitsuksanoa, Narissara Suratannon, Jongkonnee Wongpiyabovorn, Pantipa Chatchatee, Kiat Ruxrungtham, Alain Jacquet
A208 Epidemiology of Stevens-Johnson Syndrome and Toxic Epidemal Necrolysis: An Administrative Database Study
Min Suk Yang; Jin Yong Lee, Ja Yeun Kim, Han-Ki Park, Ju-Young Kim, Woo-Jung Song, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Sang-Heon Cho, Kyung-up Min, Chang-Han Park, Suk-Il Chang, Sook-Hee Song
A209 Regional Differences of Vitamin D and Food-Induced Anaphylaxis in Korea
Si-Heon Kim, Gil-Soon Choi, Su-Chin Kim, Ji Hye Kim, Ga Young Ban, Yoo Seob Shin, Hae-Sim Park, Young Min Ye
A210 Triggering Factors of Atopic Dermatitis By Severity
Yoon Ha Hwang
A211 Clinical Features of Adverse Drug Reactions of Monoclonal Antibodies in Korea
Da Woon Sim, Kyung Hee Park, Kyung Hee Park, Hye Jung Park, Hye Jung Park, Jung-Won Park, Jung-Won Park, Jae-Hyun Lee, Jae-Hyun Lee
A212 Food Allergy with Eczema Is Associated with Reduced Growth in the First Four Years of Life
Katrina Allen, Cara Beck, Jennifer Koplin, Melanie Matheson, Mimi Tang, Anne-Louise Ponsonby, Lyle Gurrin, Shyamali Dharmage, Melissa Wake, Vicki Mcwilliam
A213 The Preliminary Study on Clinical Efficacy and Impact Factors of One Year’s Dust Mite Specific Immunotherapy in Allergic Asthma and Rhinitis Children Sensitized to Dust Mite
Xiaoying Liu, Jing Wang, Li Xiang, Qun Wang
A214 Lipopolysaccharide Signaling through Toll- like Receptor 4 Could be Augmented By Dermatophagoides Farinae in the Human Middle Ear Epithelial Cell
Ji-Eun Lee, Dong-Young Kim, Chae-Seo Rhee, Chae-Seo Rhee
A215 Drug Allergy in Pregnant Adolescents: Relation with Familial and Personal Atopy, and Substances Use
Francisco Vazquez-Nava
A216 Patients and Physicians Concept of Well-Controlled Asthma: Findings from Realise Asia
Sang-Heon Cho, Jaewon Jeong, Diahn-Warng Perng, David Price, Glenn Neira, Jiangtao Lin
A217 The Role of Vasoactive Intestinal Peptide in the Pathophysiology of Acute Asthma
Olga Semernik
A218 Comparison of Serum Cytokine Levels According to the Severity in Atopic Dermatitis
Ha-Su Kim, Jin-a Jung, Ji-in Jung
A219 The Different Influence on the Regulatory T Cell Response Between Subcutanous Immnuotherapy(SCIT) and Sublingual Immunotherapy(SLIT) in Children with Asthma
Qing Miao, Li Xiang
A220 Asthma State of Affairs in Asia: Seeing through Physicians’ and Patients’ Lenses
Sang-Heon Cho, Jaewon Jeong, Diahn-Warng Perng, Jiangtao Lin, David Price
A221 Identification of Aspirin Exacerbated Respiratory Disease (AERD) Phenotypes Using Two Step Cluster Analysis
Hyun Young Lee, Hae-Sim Park, Young Min Ye, Su Chin Kim
A222 Dusty Air Pollution Are Associated with an Increase Risk of Allergic Diseases in General Population
Shokrollah Farrokhi, Mohammadkazem Gheiby
A223 A Genome-Wide Association Study of Antituberculosis Drugs-Induced Hepatitis
Sang-Heon Kim; Heung Woo Park, Sang-Hoon Kim, Young-Koo Jee
A224 The Role of peroxiredoxin6 of Bronchial Epithelial Cells in Regulating Mitochondrial Function Under Oxidative Stress By Translocation to Outside Mitochondrial Membrane
Sunjoo Park, Keun Ai Moon, Hyouk-Soo Kwon, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Kyoung Young Lee, Gyong Hwa Hong, Eun Hee Ha
A225 Toxic and Adjuvant Effects of 3 Types of Silica Nanoparticles on Airway System
Heejae Han, Hye Jung Park, Yoon Hee Park, Yoon-Jo Kim, Kangtaek Lee, Jung-Won Park, Jae-Hyun Lee
A226 Procedure for Diagnostic and Selection of Immunotherapy Method for Children with Different Immunopathogenetic Phenotypes of Atopic Dermatitis
Tatiana Slavyanskaya, Vladislava Derkach
A227 Prediction of the Success of Our Desensitization Protocol with Symptoms and Results of a Skin Prick Test in Patients with Hypersensitivity to Platinum-Based Chemotherapy
Hye Jung Park, Chein-Soo Hong, Jae-Hyun Lee, Jae-Hyun Lee, Sungryeol KIM, Sungryeol KIM, Kyung Hee Park, Kyung Hee Park, Choong-Kun Lee, Beodeul Kang, Seung-Hoon Beom, Sang Joon Shin, Minku Jung, Jung-Won Park, Jung-Won Park
A228 Anti-Allergic Effect of Intralymphatic Injection of OVA-Flagelin Mixture in Mouse Model of Allergic Rhinitis
Eun-Hee Kim, Ji-Hye Kim, Ji-Hun Mo, Young-Jun Chung
A229 Serum Periostin Level Is Higher in Respiratory Type of NSAID Hypersensitivity Than Cutaneous Type
Mi-Ae Kim, Hae-Sim Park, Moon Gyeong Yoon, Young-Soo Lee, Ji Hye Kim, Ga Young Ban, Hye-Soo Yoo, Yoo Seob Shin, Young Min Ye, Dong-Ho Nahm
A230 A Retrospective Analysis of Allergy Blood Testing in Beijing Children’s Hospital in the Year of 2013: A Single-Center Research
Qing Miao, Li Xiang
A231 Role of Nrf2 in the Allergic Airway Inflammation Differ Between BALB/c and C57BL/6 Mice
Ying-Ji Li, Takako Shimizu, Hirofumi Inagaki, Yukiyo Hirata, Hajime Takizawa, Arata Azuma, Masayuki Yamamoto, Tomoyuki Kawada
A232 Effect of Human Mesenchymal Stem Cell on Neutrophilic Asthma Model
Min-Gu Kim, Gyong Hwa Hong, Kyoung Young Lee, Eun Hee Ha, Keun Ai Moon, Sunjoo Park, Hyouk-Soo Kwon, Tae-Bum Kim, Hee-Bom Moon, You Sook Cho, Jung-Hyun Kim, Hyo-Jung Kim, So-Young Park, Bomi Seo
A233 Immunomodulatory Effect of Tonsil Derived Mesenchymal Stem Cells in a Mouse Model of Allergic Rhinitis
Ji-Hye Kim, Ramachandran Samivel, Eun-Hee Kim, Young-Jun Chung, Ji-Hun Mo
A234 Alternative Therapy Such As Yoga May be a Low Cost Tool for Improving the Quality of Life of Patient’s with Allergic Rhinitis and Asthma
Soumya M. S., G. Inbaraj, R. Chellaa, Ruby Pawankar
A235 Substantial Impairment of the Quality of Life in Adult Patients with Chronic Urticaria
Wonsun Choi, Hae-Sim Park, Young Min Ye, Ji Hye Kim, Ga Young Ban, Yoo-Seob Shin
A236 Dietary Galacto-Oligosaccharides Reduce Airway Eosinophilia and Enhance the Th2 Suppressive Effect of Budesonide in House Dust Mite-Induced Asthma in Mice
Saskia Braber, Kim Verheijden, Aletta Kraneveld, Johan Garssen, Linette Willemsen, Gert Folkerts
A237 Production and Characterization of Recombinant Periplaneta americana Allergens for Component Resolved Diagnosis
Stephanie Eichhorn, Fatima Ferreira, Isabel Pablos, Bianca Kastner, Bettina Schweidler, Sabrina Wildner, Peter Briza, Jung-Won Park, Naveen Arora, Stefan Vieths, Gabriele Gadermaier
A238 Assessment of Characteristics of Itch in Patients with Hand Eczema
Sung-Min Park, Won-Ku Lee, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Hoon-Soo Kim, Margaret Song, Hyun-Chang Ko, Moon-Bum Kim, Byung Soo Kim
A239 The Hidden Culprit: A Case of Repeated Anaphylaxis from Cremophor Hypersensitivity.
Young Nam Kim, Sehyo Yune, Jin-Young Lee, Jihye Kim, Young Eun Kim, Jae-Won Paeng, Mi-Jin Jang, Dong-Chull Choi, Byung-Jae Lee, Yongseok Lee
A240 Spectrum of Anaphylaxis in Children and Adults at Emergency Departments in Singapore
Si Hui Goh, Bee Wah Lee, Jian Yi Soh
A241 Improved Quality of Life through an Integrated Health Care Service for Children with Atopic Dermatitis
Hyungoo Kang; Hyunhee Kim; Hye-Yung Yum
A242 Criteria Combining Autologous Serum Skin Test and Clusterin for Predicting Antihistamine-Refractoriness in Patients with Chronic Spontaneous Urticaria
Young Min Ye; Hae-Sim Park; Ga-Young Ban; Ji Hye Kim; Yoo Seob Shin
A243 Urinary Leukotriene E4 Levels in Wheezing Infants
Takumi Takizawa, Masahiko Tabata, Akira Aizawa, Hisako Yagi, Yutaka Nishida, Hirokazu Arakawa, Akihiro Morikawa, Solongo Orosoo
A244 Allergic Sensitization to Whey in Mice Is Facilitated By the Mycotoxin Deoxynivalenol (DON)
Saskia Braber, Marianne Bol-Schoenmakers, Peyman Akbari, Prescilla V. Jeurink, Prescilla V. Jeurink, Priscilla De Graaff, Joost J. Smit, Betty C. A. M. Van Esch, Johan Garssen, Johan Garssen, Johanna Fink-Gremmels, Raymond H. H. Pieters
A245 How to Define Chronic Cough: Based on a Systematic Review of the Epidemiological Literature
Gun-Woo Kim, Eun-Jung Jo, Sujeong Kim, Woo-Jung Song, Yoon-Seok Chang, Shoaib Faruqi, Ju-Young Kim, Mingyu Kang, Min-Hye Kim, Jana Plevkova, Heung Woo Park, Sang-Heon Cho, Alyn Morice, So-Hee Lee, Sun-Sin Kim, Seoung-Eun Lee
A246 Asko Study: Comparison of Behavior and Habits in Diagnosis and Treatment of Adult Asthma and COPD Patients
Bilun Gemicioglu, Zeynep Misirligil, Arif Hikmet Cimrin, Hakan Gunen, Tevfik Ozlu, Aykut Cilli, Levent Akyildiz, Hasan Bayram, Esra Uzaslan, Oznur Abadoglu, Mecit Suerdem
A247 Changes in Pulmonary Function in the Treatment of Obesity in Children
Keigo Kainuma
A248 Changes of Feno and Nasal Feno Levels after Treatment in Pediatric Allergic Rhinitis
Hyun-a Kim, Ha-Su Kim, Woo Yong Bae, Jin-a Jung
A249 Prevalence of Vitamin D Deficiency in Exclusively Breastfed Infants in Kenya
Rose Kamenwa, William Macharia, Nusrat Said
A250 In-Vitro Screening of Atopy in the Indian Population: Are Current Methods Adequate, Keeping Local IgE Seroprevalence for Common Food & Inhalant Allergens in Mind?
Vidya Nerurkar, Meenal Patel, Simi Bhatia
A251 Usefulness of House Dust Mites Nasal Provocation Test in Asthma
Inseon S Choi, Soo-Jeong Kim, Joo-Min Won, Myeong-Soo Park
A252 Biomarker-Based Treatment Option for Preschool Children with Recurrent Wheeze
Mizuho Nagao
A253 Anti-Tuberculosis Drugs-Induced Liver Injury in Patients with Connective Tissue Diseases
Dong Won Park, Jang Won Sohn, Ji Young Yhi, Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Dong Ho Shin, Ho Joo Yoon
A254 Ocular Symptoms of Cedar Pollinosis in Otolaryngology Patients
Yukiyoshi Hyo
A255 The Clinical Characteristics of Adverse Drug Reactions Reported in a Regional University Hospital for 6 Years and the Suggestions for the Reporting System
Jaechun Lee, Su Hee Kim, Eunkyoung Lee
A256 Changes in Skin Prick Test Results over 3 Years in School-Aged Children
Hahn Jin Jung, Jaehyun Lim, Seung-No Hong, Doo Hee Han, Chae-Seo Rhee
A257 The Analysis of Risk Factors and Features of Food Allergy in Korean Children: Nationwide Cross-Sectional Survey
Kun Song Lee
A258 A Sequential Indirect-Direct Bronchial Provocation Test for Diagnosis of Asthma: A Pilot Study
Jaechun Lee, Sun Young Yang, Mi Young Ahn, Jong Hoo Lee, Jasmina Golez
A259 Association of VDR and CYP2R1 Polymorphisms with Persistent Allergic Rhinitis in a Han Chinese Population
Hui-Qin Tian, Lei Cheng, Xin-Yuan Chen
A260 Associations of Metabolic Syndrome with Asthma and Atopy in Korean Adults
Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Ji Young Yhi, Ho Joo Yoon, Jang Won Sohn, Dong Ho Shin, Dong Won Park
A261 Clinical Manifestation and Treatment Outcome of Eosinophilic Gastroenteritis in Korean Children
Won Im Cho, Jong Sub Choi, Dongin Suh, Gyeong Hoon Kang, Jin Soo Moon, Jae Sung Ko, Kyung Jae Lee, Shin Jie Choi
A262 The Sensitization Model and Correlation of Bermuda and Timothy Grass Pollen Allergen in Allergic Patients in Southern China
Wenting Luo, Baoqing Sun
A263 A Pilot Study on the Outcomes of Respiratory Allergic Diseases at Pre-School Age in Chinese Infants with Atopic Dermatitis
Qi Gao, Li Xiang, Kunling Shen
A264 Activation of Toll like Receptor 1 and 6 By House Dust Mite Enhances the Expression of Tight Junction Protein in Epidermal Keratinocytes
Yong Hyun Jang
A265 Pollen Exposure in a Mobile Exposure Chamber: Comparing Real-Life Symptoms with Exposure Symptoms
Karl-Christian Bergmann, Torsten Sehlinger, Georg Bölke, Uwe Berger, Torsten Zuberbier
A266 Retrospective Analysis of the Incidence of Allergy in Patients with Contact Eczema
Joanna Kolodziejczyk, Milena Wojciechowska, Anna Hnatyszyn-Dzikowska, Micha Chojnacki, Zbigniew Bartuzi
A267 Effect of Fungal Sensitization in Patients with Severe Asthma
Katsunori Masaki, Koichi Fukunaga, Takashi Kamatani, Kengo Ohtsuka, Takae Tanosaki, Masako Matsusaka, Takao Mochimaru, Hiroki Kabata, Soichiro Ueda, Yusuke Suzuki, Katsuhiko Kamei, Koichiro Asano, Tomoko Betsuyaku
A268 SCIg Patient Preference Pump Versus Push
Karlee Trafford
A269 Fixed Drug Eruption Induced By Ornidazole and Diclofenac
Ismet Bulut, Zeynep Ferhan Ozseker
A270 Transepidermal Water Loss Measurement during Infancy Can Predict the Subsequent Development of Atopic Dermatitis
Kenta Horimukai, Hideaki Morita, Masami Narita, Hironori Niizeki, Kenji Matsumoto, Yukihiro Ohya, Hirohisa Saito, Shigenori Kabashima, Mai Kondo, Eisuke Inoue
A271 Inhalant Allergens on Soft Toys: A Literature Review
Robert Siebers, Francis FS Wu
A272 Fractional Exhaled Nitric Oxide in Elderly Asthmatics
Robert Siebers, Francis FS Wu, Ming-Hui Ting, Hung-En Laio, Tsung-Huai Kuo, Pei-Yuan Lee
A273 Dye and Preservative Challenge in Meal-Associated Urticaria and Angioedema: A Low-Yield Diagnostic Maneuver
Daniel Eugene Maddox
A274 The Changes of Allergic Sensitization with Age in Children with Allergic Rhinitis
Gwanghui RyuHyo Yeol Kim, Hun-Jong Dhong, Sang Duk Hong, Seung-Kyu Chung
A275 Component-Specific IgE and IgG4 Levels in Milk Allergy Children Tolerated Baked Milk Products
Osamu Higuchi, Yu-Ichi Adachi, Toshiko Itazawa, Yoko Adachi, Miki Hamamichi, Motokazu Nakabayashi, Yasunori Ito, Takuya Wada, Gyoukei Murakami, Miki Takao, Junko Yamamoto
A276 Serum Surfactant Protein(SP)-D Level: A Potential Biomarker for Aspirin-Exacerbated Respiratory Disease
Hyun Jung Jin, Moon Gyeong Yoon, Young Min Ye, Yoo-Seob Shin, Seung-Hyun Kim, Hae-Sim Park
A277 Clinical Characteristics of Anaphylaxis in Korean Children
Taek-Ki Min, Bok-Yang Pyun, So-Yeon Lee, Hyun Hee Kim, Gwang-Cheon Jang, Jinho Yu, Dongin Suh, Sooyoung Lee, Yong Mean Park, Jeong Hee Kim, Hye-Yung Yum, Kyung Won Kim, Hyeon-Jong Yang, Kangmo Ahn, Ji-Won Kwon, Myung Hyun Sohn, Hae Ran Lee, Jung Hyun Kwon, Kyu-Earn Kim, Soo-Jong Hong
A278 Immunological Changes Induced By Intramuscular Injections of Autolologous Immunoglobulin in Patients with Severe Atopic Dermatitis
Su-Mi Cho
A279 Identification of Subtypes in Subjects with Mild to Moderate Airflow Limitation and Their Clinical and Socioeconomic Implications
Jin Hwa Lee, Chin Kook Rhee, Hye Yun Park, Woo Jin Kim, Yong Bum Park, Kwang-Ha Yoo
A280 Cephalosporin-Induced Dress (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome in a 7-Year-Old Boy
Heejeong Kang, Hyeon-Jong Yang, Taek-Ki Min, Bok-Yang Pyun
A281 Maternal Depression Is Associated with Children’s Asthma : An Analysis of the Fifth Korea National Health and Nutrition Examination Survey (2010-2012)
Lee Ju Suk, Cheol Hong Kim
A282 Increased Length of Hospitalization Associated with Infiltration on Chest Radiography in Pediatric Asthma Patients
Jung Hyun Kwon, Sang Hyun Lee, Wonhee Seo
A283 A Case of 16-Year-Old Boy with Smoking-Induced Acute Eosinophilic Pneumonia
Kang-in Kim, Young Cheon Park, Hyeon-Jong Yang, Taek-Ki Min; Bok-Yang Pyun
A284 A Case of Pranlukast Induced Anaphylactic Shock
Sujeong Kim, Sun Jin, Jong-Myung Lee, Hye-Jin Jung, Jung-Wha Park
A285 Comparison of Asthma-Related Outcomes Between Metabolically Healthy Obese and Metabolically Unhealthy Obese Asthma Patients
Hyo-Jung Kim, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon, So Young Park, So-Young Park, Jung-Hyun Kim, Bomi Seo, Min-Gu Kim, Youn Yee Kim
A286 Rick Factors Associated with Longer Length of Stay in Infants Hospitalized with Respiratory Syncytial Virus Bronchiolitis
Yena Lee, Taek-Ki Min, Hyeon-Jong Yang, Bok-Yang Pyun, Suk Hee Han, Suyeon Park, Jeongho Lee, Won-Ho Hahn
A287 Urinary Excretion of 9α, 11Î2-Prostaglandin F2 and Leukotriene E4 in Patients with Exercise-Induced Bronchoconstriction
Youhoon Jeon, Joo-Hee Kim, Tae-Rim Shin, Cheol-Hong Kim, In-Gyu Hyun, Jeong-Hee Choi
A288 The Aeroallergen Sensitization Pattern and Effect on Airway Hyperresponsiveness in Busan, Korea
Sun-Mi Jang, Hae-Jung Na, Seung-Eon Song, Hye-Kyung Park, Eun-Jung Jo
A289 Multicenter Questionnaires on Current Management of Atopic Dermatitis Among Korean Patients and Caregivers
Dong Hun Lee, Jin-Young Lee, Yang Park, Jae-Won Oh, Mi Hee Lee, Soo-Jong Hong, Soo-Jong Hong, So-Yeon Lee, Joon Soo Park, Dong-Ho Nahm, Hye-Yung Yum, Hye-Yung Yum
A290 Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea
Kyu Young, Dong-Young Kim
A291 De-Labeling Beta-Lactam Hypersensitivity: An Experience from a Tertiary Care Hospital in Thailand
Sirinoot Palapinyo; Jettanong Klaewsongkram
A292 Sonic Hedgehog Signaling: Evidence for Its Protective Role in Endotoxin Induced Acute Lung Injury Mouse Model
Xing Chen, Yuting Jin, Xiaoming Hou, Fengqin Liu, Chunyan Guo, Yulin Wang
A293 Analyses of the Factors behind the Negative Attitudes Toward the Administration of Adrenaline Auto-Injectors in School Settings
Ikuo Okafuji, Yuya Tanaka, Shegeyuki Narabayashi, Satoru Tsuruta
A294 Low Vitamin D Levels Are Related to High House Dust Mite Sensitization in Patients with Severe Atopic Dermatitis
Yong Hyun Jang
A295 Appendicular Skeletal Muscle Mass Index: A Potential Predictor of Skeletal Muscle Abnormality According to the Severity Airflow Limitation of COPD
Jun-Hong Ahn, Dong-Won Lee, Jin Hong Chung, Hyun Jung Jin, Min-Su Sohn
A296 Etiology and Clinical Feature of Oral Allergy Syndrome in Children
Young a Park, Kyunguk Jeong, Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Sooyoung Lee
A297 Traffic-Related Pollution Levels and Poorly Controlled Asthma in Adults
Ho Kim, Ja Yeun Kim
A298 Anaphylaxis in Korean Children, 2009-2013 : Triggers of Anaphylaxis By Age Groups
So-Yeon Lee, Taek-Ki Min, Tae-Won Song, Kangmo Ahn, Jihyun Kim, Gwang-Cheon Jang, Hyeon-Jong Yang, Bok-Yang Pyun, Ji-Won Kwon, Myung Hyun Sohn, Kyu-Earn Kim, Jinho Yu, Soo-Jong Hong, Jung-Hyun Kwon, Sung-Won Kim, Sooyoung Lee, Woo Kyung Kim, Hyung Young Kim, Hye-Young Kim, Youhoon Jeon
A299 Maternal Allergy Is Associated with Acute Bronchiolitis Severity in Infant
Chang Hoon Lim, Yeongsang Jeong, Su Jung Kim
A300 Evaluation of Inflammatory Mediator Profiles in Sputum of Asthmatics As an Endotype for Refractory Asthma
Hun Soo Chang, Jeong-Seok Heo, Da-Jeong Bae, Jong-Uk Lee, Ji-Na Kim, Chang-Gi Min, Hyun Ji Song, Jong-Sook Park, Soo Hyun Kim, Choon-Sik Park
A301 Autophagy Is Associated with the Severity of Asthma in an Ovalbumin-Specific Mouse Model of Allergic Asthma
Jing-Nan Liu, Youngwoo Choi, Yoo Seob Shin, Hae-Sim Park
A302 Interleukin-9 and Interleukin-33 Levels in Children with Asthma
Nima Rezaei, Sedigheh Bahrami Mahneh, Arezou Rezaei, Maryam Sadr, Masoud Movahedi
A303 Pediatric Anaphylaxis at a University Hospital in Cheonan, Korea, 2013~2014
Jun Seak Gang, Joon Soo Park, Seung Soo Kim, Hyun Ho Bang, Kyeong Bae Park, Hye Sun Kim, Tae Ho Kim, Young Hwangbo, Hyun Jung Lee, Gyeong Hee Yoo, Young Chang Kim
A304 Initial Antigen-Specific IgE Levels Predict Clinical Outcome of Rush Oral Immunotherapy for Food Anaphylaxis
Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa
A305 ABCC4 gene Polymorphism Is Associated with High Periostin Levels in Asthmatic Patients
Sailesh Palikhe, Hae-Sim Park, Seung-Hyun Kim, Ri-Yeon Kim, Eun-Mi Yang
A306 The Role of Clinical Phenotype and Allergen Sensitization at 2 Years As Predictors of Atopic Disorders at 5 Years
Li Yuan Gabriella Nadine Lee, Marion Aw, Marion Aw, Bee Wah Lee, Bee Wah Lee, Evelyn Xiu Ling Loo, Yiong Huak Chan, Lynette Shek, Lynette Shek, I-Chun Kuo, I-Chun Kuo, Phaik Ling Quah, Phaik Ling Quah, Genevieve Llanora, Gerez Irvin
A307 The Effect of Korean Red Ginseng (KRG) on Rhinovirus Infection in Human Nasal Epithelial Cells
Joo Hyun Jung, Il Gyu Kang, Seon Tae Kim, Hyoungmin Park
A308 The Effect of Korean Red Ginseng on the Symptoms and Allergic Inflammation in Patients with Allergic Rhinitis
Seon Tae Kim, Joo Hyun Jung, Il Gyu Kang, Hyoungmin Park, Kwang-Pil Ko
A309 Validation of the Newly Developed Multiple Allergen Simultaneous Test in Korea
Jungsoo Lee, Howard Chu, Hemin Lee, Jung U Shin, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee, Hong Kyu Kang
A310 Assessment of Symptoms Severities of Allergic Rhinitis Patients Sensitive to Multiple Allergens in Skin Prick Test
Dong Chang Lee, Geun Jeon Kim, Jae Hyung Hwang, Jin Bu Ha, Su Hee Jeong
A311 Diurnal Temperature Range and Emergency Department Visits for Asthma in Korea 6 Cities
Ho Kim, Shinha Hwang, Whahee Lee
A312 Mannan-Binding Lectin Serum Levels in Atopic Mongolian Adults
Enkhbayar Bazarsad, Logii Narantsetseg, Munkhbayarlakh Sonomjamts
A313 Prevalence of Doctor Diagnosed Atopic Eczema, during 2003-2014 in KOREA ; Using Big Data of 48.1 Million South Korean Health-Care Records
Gwang-Cheon Jang, Hyun-Hee Lee, Chang-Jong Lee, Huynsun Lim
A314 Association of Recurrent Wheeze with Lung Function and Airway Inflammation in Preschool Children
Ji-Eun Soh, Dae-Jin Song, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
A315 Mannan-Binding Lectin Serum Levels in Healthy Mongolian Adults
Enkhbayar Bazarsad, Logii Narantsetseg, Munkhbayarlakh Sonomjamts
A316 Rotanebuliser
Prabhakarrao Pv, Ranjitha Nadendla
A317 The Level of Serum Interleukin 13 and Interleukin 17A and Its Effect Factors in Children with Asthma
Juan Fang, Jing Zhao
A318 Is Vitamin D Insufficiency Also Involved in Childhood Asthma in South Korea?
Dae-Jin Song, Sungchul Seo, Young Yoo, Yu-Ri Kim, Ji Tae Choung, Jee Hoo Lee
A319 Collection of Nasal Secretions for Measurement of Local IgE: A Quest for the Best Method
Margot Berings, Natalie De Ruyck, Claus Bachert, Philippe Gevaert, Gabriële Holtappels
A320 The Role of Claudin 5 in a Murine Model of Asthma
Pureun-Haneul Lee, Byeong-Gon Kim, Choon-Sik Park, George D Leikauf, An-Soo Jang
A321 Claudin-4 in a Murine Model of Asthma: Modulation By Acrolein, a Highly Reactive Unsaturated Aldehyde
Byeong-Gon Kim, Pureun-Haneul Lee, Choon-Sik Park, An-Soo Jang
A322 Efficacy and Safety of Sublingual Immunotherapy in House Dust Mite Sensitized Children with Allergic Rhinitis
Yang Park
A323 The Association of Vitamine D Deficiency and Skeletal Muscle Dysfunction in Chronic Airway Disease
Min-Su Sohn, Hyun Jung Jin, Dong-Won Lee, Jun-Hong Ahn, Jin Hong Chung
A324 Bacteria Derived Extracellular Vesicles in Indoor Dust Is Closely Associated with Airway Disease and Lung Cancer: Analysis of Indoor Dust’s Microbiome and IgG Sensitization of Indoor Bacteria Derived Extracellular Vesicles
Sae-in Kim, Han-Ki Park, Do-Yeon Kim, Mina Rho, Jun-Pyo Choi, Yoon-Keun Kim
A325 Clinical Care Program for Childhood Asthma (CCP-Childhood Asthma); A Multidisciplinary Team Care at Samitivej International Children’s Hospital
Wasu Kamchaisatian, Thitikul Hiranras, Surinda Wongpun, Phornthip Chiraphorn, Anupan Tantachun, Wannipa Wongrassamee, Planee Vatanasurkitt, Naratip Somboonkul, Nattipat Juthacharoenwong, Surangkana Techapaitoon, Montri Tuchinda
A326 Continuous B Cell Stimulation with CD40 Ligand Induce IgE Isotype Switching
Jae Ho Lee, Sejin An
A327 Effects of Interleukin-9 on Allergen-Specific Immunotherapy in a Mouse Model of Allergic Rhinitis
Ji-Hyeon Shin, Soo Whan Kim, Si Won Kim, Jun Myung Kang, Boo-Young Kim, Byung-Guk Kim
A328 Usefulness of Exhaled Nitric Oxide for Evaluating Wheeze and Airway Hyperresponsiveness in Preschool Children
Jung-Won Lee, Ji-Won Kwon, Woo Kyung Kim, Hyung Young Kim, Hyo-Bin Kim, Ju-Hee Seo, So-Yeon Lee, Gwang-Cheon Jang, Young-Ho Jung, Soo-Jong Hong, Byoung-Ju Kim, Dae-Jin Song, Jung Yeon Shim
A329 Systemic Cyclosporine Treatment in Hand Eczema Patients
Kyung Ho Kim
A330 Lipid Profiles and Adipokines in Korean Children with Atopic Dermatitis
Young Yoo, Won Suck Yoon, Sungchul Seo, In Soon Kang, Jae Won Choi, Hye-Young Lim, Ji Tae Choung
A331 Validation of Montelukast and Levocetirizine Combination Tablet Versus Individual Tablets in the Treatment of Moderate to Severe Persistent Allergic Rhinitis Among Adult Filipinos Seen at the Philippine General Hospital-Outpatient Department
Michelle Buela
A332 Efficacy of Makyokansekito on Treatment of Wheezing Lower Respiratory Tract Infection in Children: A Retrospective Study of 68 Patients
Koji Nishimura
A333 Serum Eosinophilia and Total IgE Are Associated with the Risk of Allergic Sensitization and Allergic Symptoms in Two Years Follow-up, Respectively
Sang Chul Park, Hyo Jin Chung, Chang-Hoon Kim, Ju Wan Kang, Seong-Chul Hong, Keun-Hwa Lee, Jaechun Lee, Hye-Sook Lee, Jeong Hong Kim
A334 The Sensitization to Russian Thistle on Mongolian Patients
Narantsetseg Logii
A335 The Association Between Air Pollution, Allergic Sensitization to Inhalant Allergens and Airway Hyperresponsiveness in Ulaanbaatar, Mongolia
Munkhbayarlakh Sonomjamts, Enkhbayar Bazarsad
A336 Pre-Coseasonal Treatment with a 5-Grass Pollen Sublingual Tablet in Adults Demonstrated a Reduction on Asthma Symptoms in Réunion Island
Bashir Omarjee
A337 Peak Expiratory Flow Rate Reference Values for Children Aged 5-14 Years Old in Beijing Urban Area
Shuo LI
A338 Soybean Storage Proteins As the Main Allergen in a Patient with Food-Dependent Exercise-Induced Anaphylaxis Due to Tofu
Miyuki Hayashi, Ruby Pawankar, Shingo Yamanishi, Toru Igarashi, Yasuhiko Itoh
A339 A Study of Allergy Skin Prick Test with Weed Pollen
Oyuntsatsral Batsaikhan, B. Gantulga, B. Enkhbayar, S. Munkhbayarlakh, L.Narantsetseg
A340 The Role of Neurotrophin in a Murine Model of House Dust Mite Induced Allergic Rhinitis
Pei-Chi Chen, Jiu-Yao Wang
A341 Mimotopes of the Major Shellfish Allergen Tropomyosin Suppress Splenocyte Proliferation and Local Cytokine Expression in a Mouse Model of Shellfish Allergy
Nicki Y. H. Leung, Christine Yee Yan Wai, Patrick S.C. Leung, Ka Hou Chu
A342 A Questionnaire Survey on Understanding of Atopic Dermatitis Among Korean Patients and Caregivers
Eun Jin Doh, Dong Hun Lee, Mira Choi, Hyun-Sun Yoon, Kyu Han Kim, Ji Soo Lim
A343 Comparison of the Dosage of Bronchodilators in the Bronchodilator Response Test in Children
Ji Hyeon Baek, Man Yong Han, Seung Jin Lee, Youhoon Jeon, Kyung Suk Lee, Young-Ho Jung, Hye Mi Jee, Youn Ho Shin
A344 The Expression and Effect of Natural Killer T Lymphocytes in Chidren with Asthma
Yi Jiang, Miao Liu
A345 Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital
Chaw Su Naing, Tze Chin Tan, Yong Yeow Chong
A346 Different Phenotypes of Bhr (bronchial hyperresponsiveness) By Natural Course in Children and It’s Characteristics
Young-Ho Kim, Eun Lee, Song-I Yang, Hyun-Ju Cho, Hyung Young Kim, Ji-Won Kwon, Young-Ho Jung, Byoung-Ju Kim, Ju-Hee Seo, Ho-Jang Kwon, Hyo-Bin Kim, So-Yeon Lee, Soo-Jong Hong, Soo Hyun Kim
A347 Spectrum of Allergens Causing Allergic Rhinitis and Asthma in Urban Bangalore, India − a Study of 120 Patients
Jacqueline Elizabeth Joseph, Soumya M. S, Ruby Pawankar, Harshitha Kumar
A348 High Prevalence of Wheezing Illness and Risk Factor of Atopic Asthma Progression in Korean Preschool Children
Sohyoung Yang, Sung-Il Woo
A349 Clinical and Laboratory Screening of Primary Immunodeficiency Diseases: International Effects
Nima Rezaei
A350 The Effect of Helicobacter Pylori Infection in Atopic Individuals
Sukran Kose, Basak Gol Serin, Arzu Didem Yalcin, Süheyla Serin Senger, Mehmet Erden, Ertan Serin
A351 Clinical Spectrum and Natural History of Chronic Urticaria in Hong Kong Children
Agnes Sze-Yin Leung, Ting Fan Leung
A352 Skin Prick Test Reactivity to Common Pollen Aeroallergens in Patients with Allergic Rhinitis − in Urban Bangalore, India
Harshitha Kumar, Soumya M.S., Jacqueline Elizabeth Joseph, Ruby Pawankar
A353 Seasonal Patterns of Asthma-Related ED Visits and Admissions in Children and Adolescents Who Visited Emergency Rooms of Korea in 2007-2012
Eun Hee Chung
A354 Prevalence of Atopic Dermatitis and Its Associated Risk Factors in Elementary School Children: A Cross-Sectional Study in Gyeonggi-Do, South Korea
Eunji Kim, Young Yoo, Ji Tae Choung, Sungchul Seo, In Soon Kang, Jue Seong Lee, Ji Hyen Hwang
A355 Intralymphatic Immunotherapy for Dermatophagoides Farinae, Dermatophagoides Pteronyssinus, Cat, and/or Dog Allergy in Patients with Allergic Rhinitis: 1 Year Follow-up
Sang Min Lee, Joo Hyun Jung, Seung Joon Choi, Eugene Joe, Hyunjung Hwang, Shin Myung Kang, Yu Jin Kim, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Sang Pyo Lee
A356 Respiratory Syncytial Virus Regulates IL-33 Expression in Bronchoalveolar Cells and Lung Tissue in Vivo
Alina Gaisina, Igor Shilovskiy, Aleksandra Nikonova, Oleg Kamyshnikov, Musa Khaitov, Alexander Mitin, Komogorova Viktoriya, Marina Litvina, Nina Sharova
A357 The Prevalence of Parent-Perceived Food Hypersensitivity in Pre-School Children Attending a Tertiary Care Hospital in Malaysia
Faizah Mohamed Jamli
A358 Th2 Dominant Airway Inflammation Induced By House Dust Mite Chitin Is Dependent on TNF-a and NKT Cell
Da-Il Yoon, Jun-Pyo Choi, Han-Byul Choi, Yoon-Keun Kim, Hyeon-Il Choi
A359 Geographic Variations in the Patterns of Sensitization to Aeroallergens in Korean Adults: A Multi-Center Study
Mingyu Kang, Mi Yeoung Kim, Sujeong Kim, Eun-Jung Jo, Seoung-Eun Lee, Woo-Jung Song, Sang Min Lee, Chansun Park, Yoon-Seok Chang, Jaechun Lee, Young-Koo Jee, Inseon S Choi, Kyung-up Min, Sang-Heon Cho
A360 Experimental Mouse Model of Asthma Induced By Dust Mite Dermatophagoides Pteronyssinus allergenic Extract
Anton Laskin, Oleg Kamyshnikov, Alexander Babakhin, Valentina Berzhets, Musa Khaitov
A361 Severe Refractory Pulmonary Complications in Children with Mycoplasma Pneumoniae Pneumonia
Sejin An, Jae Ho Lee
A362 Usefulness of Interactive e-Learning Education Program for Asthma Guideline
Sung-Yoon Kang, Yoon-Seok Chang, Kyung-up Min, Sang-Heon Cho, Sae-Hoon Kim, Yong Eun Kwon, Young-Koo Jee, Tae-Bum Kim, Hee-Bom Moon, Hye-Kyung Park
A363 Airway Inflammation Induced By House Dust Mite Derived Vesicles Is Mainly Induced By LPS Derived from Gram Negative Bacteria in Dust Mite.
Sang-Yoon Kim, Jun-Pyo Choi, Han-Ki Park, Ji-Hyun Lee, Yoon-Keun Kim
A364 Changes in the Recognition of Causal Allergen, Its Avoidance, and Allergen Specific Immunotherapy after Skin Prick Test / Intradermal Test, Nasal Provocation Test, and Intralymphatic Immunotherapy in Patients with Allergic Rhinitis: 1 Year Follow-up
Hyunjung Hwang, Eugene Joe, Sang Min Lee, Seung Joon Choi, Joo Hyun Jung, Yong Han Seon, Shin Myung Kang, Yu Jin Kim, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Sang Pyo Lee
A365 Laboratory Diagnostic of Staphylococcal Sensitization
Natalya Khramykhoverchenko
A366 Th-17 Regulatory Cytokines Enhance Neutrophil Production of IL-17 during Asthma
Saleh Al Muhsen, Asma Sultana, Rabih Halwani, Ahmed Bahammam
A367 Diagnostic Value of Serum Total IgE and Prediction of Cut-Off Value to Recommend Mast in Allergic Rhinitis
Hyung Chae Yang, Sun Kyung Kim, Kwang Il Nam
A368 Diagnostic Value of an Increase in FEV1 and/or FVC >12% and >200 mL from Baseline after Bronchodilators for Diagnosis of Asthma
Jeong-Eun Kim, Ju Suk Lee, Ji Hyun Lee, Kyung Woo Kang
A369 Combined Use of Fractional Exhaled Nitric Oxide and Bronchodilator Response in Predicting Future Loss of Asthma Control Among Children with Atopic Asthma
Je-Kyung Kim, Youn-Soo Hahn, Jae-Yub Jung
A370 Antigen-Specific IgA Plays an Important Role in Mucosal Immune Response in Allergic Children : Measurement of Secretory IgA and Antigen-Specific IgA
Yosuke Baba, Sususmu Yamazaki, Eisuke Inage, Mari Mori, Yoshikazu Ohtsuka, Masato Kantake, Toshiaki Shimizu, Asuka Honjoh, Tomoaki Yokokura
A371 Why Teaching Pediatrics Trainees about Anaphylaxis and Its Acute Management Is Essential: Cross Sectional Survey.
Mehdi Adeli, Shaza Ali Mohammed Elhassan, Caroline Beck
A372 Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children
Min Sun Na, Heysung Baek, Seung Jin Lee, Ji Hyeon Baek, Jungwon Yoon, Sun Hee Choi, Young-Ho Jung, Youn Ho Shin, Man Yong Han
A373 House Dust Mites Sublingual Immunotherapy Can Influence the Long-Term Evolution of Severe Atopic Dermatitis and the Progression to Respiratory Allergy.
Enrico Compalati, Maurizio Marogna
A374 The Positive Distribution Characteristics of 90 Food Specific IgG in Patients with Allergic Diseases
Huimin Huang, Baoqing Sun, Mingyu BAI, Yiting Huo, Peiyan Zheng, Nili Wei, Wenting Luo
A375 Evaluation of Serum Levels of Osteopontin As a Potential Biomarker of Immune Activation in Patients with Allergic Diseases
Elisa Villa, Anand Andiappan, Rosalba Minisini, Olaf Rötzschke, Elena Boggio, Luca Gigliotti, Nausicaa Clemente, Annalisa Chiocchetti, Umberto Dianzani, Mario Pirisi
A376 Prevalence of Allergic Rhinitis in 3-6-Year-Old (preschool) Children in Chiba City (urban area), Japan
Fumiya Yamaide, Syuji Yonekura, Naoki Shimojo, Yuzaburo Inoue, Yoshitaka Okamoto
A377 Comparative Efficacy of Combination Nebulized Salbutamol and Fluticasone Propionate and Nebulized Salbutamol in Children with Mild Moderate Asthma Attack
Retno Asih Setyoningrum, Landia Setiawati, Sri Sumei, Deddy Iskandar
A378 Characteristics of Children Hospitalized with Asthma in West Nusa Tenggara General Hospital Mataram Indonesia
Indriyani Sang Ayu Kompiyang
A379 Identification of Phenotypes in Allergic Bronchopulmonary Aspergillosis Using Cluster Analysis
Tsuyoshi Oguma, Jun Tanaka, Katsuyoshi Tomomatsu, Koichiro Asano
A380 The Roles of Type 2 Innate Lymphoid Cells (ILC2) in Chronic Rhinosinusitis (CRS)
Keisuke Uno, Yoshinori Matsuwaki, Kazuhiro Omura, Eika Hayashi, Norifumi Tatsumi, Hirohito Kita, Nobuyoshi Otori, Hiromi Kojima
A381 Respiratory Symptoms, Signs and Spirometry Indexes Comparision in 7-12 Years Old Girls in Esfahan Metropolis and Its Far Suburb
Mohammadreza Fatemi Khorasgani
A382 Induction of Kruppel-like Transcription Factor (KLF4&5) By Baker’s Yeast Mannan in Human Bronchial Epithelial and Smooth Muscle Cells
Dukhee/Betty Lew, Kim/S. Lemessurier, Joseph/a Moore, Jeoung-Eun Park, Ae-Kyung Yi, Chi/Young Song, Kafait/U Malik
A383 Korean Profile in Childhood Asthma Severity Classification
Dongin Suh, Ja Kyoung Kim, Hyeon-Jong Yang, Bong-Seong Kim, Youn Ho Shin, So-Yeon Lee, Geunhwa Park, Woo Kyung Kim, Hyo-Bin Kim, Heysung Baek, Dae Hyun Lim, Dae Hyun Lim, Jin Tack Kim
A384 Prevalence of Food Sensitization, IgE-Mediated and Non-IgE-Mediated Food Allergy Among Pediatric Patients Diagnosed with Autism Spectrum Disorders
Aimee Lou Manalo Nano
A385 Component-Resolved Diagnostic Study of Dermatophagoides Pteronyssinus Major Allergen Molecules in a Southern China
Wenting Luo, Baoqing Sun
A386 Risk Factors for Systemic and Local Reactions to Subcutaneous Allergen Immunotherapy
Hikmet Tekin Nacaroglu, Semiha Bahceci Erdem, Ozlem Sumer, Sait Karaman, Canan Sule Unsal Karkiner, Suna Asilsoy, Ilker Gunay, Demet Can
A387 Literature Review and Current Treatment Options for Cyclical Anaphylaxis
Danielle Kiers
A388 The Effect of Surfactant Protein D in Acute Lung Injury and Pulmonary Fibrosis Induced By Bleomycin
Hsu Han Yin, Jiu-Yao Wang
A389 Activation of Endothelial Cells to Release Hsp90, an Activator of the Prekallikrein-High Molecular Weight Kininogen (HK) Complex
Allen Kaplan, Kusumam Joseph, Baby G. Tholanikunnel
A390 The Effect of Climatic Treatment in 51 Asthmatic Children from Areas Severely Polluted Environment of Northern Moravia, Czech Republic
Radim Dudek
A391 Comparison of Some Vitamin Groups in Asthmatic Patients
Gulden Bilgin, Hatice Surer, Aytun Sadan Kilinc, Dogan Yucel
A392 Sensitization in Children with Atopic Dermatitis: A Single Center Study
Ji Young Lee, Jihyun Kim, Hea-Kyoung Yang, Minji Kim, Sang-Il Lee, Kangmo Ahn
A393 Staphylococcal Enterotoxin IgE Sensitization: A Risk Factor for COPD Overlap in the Elderly Asthma?
Sung Do Moon, Byung-Keun Kim, Sang-Heon Cho, Kyung-up Min, Yoon-Seok Chang, Heung Woo Park, Hye-Ryun Kang, Woo-Jung Song, Min-Koo Kang, Ju-Young Kim, Kyonghee Sohn, Ha Kyung Won, Seoung-Eun Lee, Kyung-Mook Kim, Claus Bachert
A394 The Effects of Probiotics and PparÎ3 on the Murine Model of Allergic Asthma
Miao-Hsi Hsieh, Jiu-Yao Wang
A395 Adult Patients’ Views on the Design of Adrenaline Autoinjectors
Helen Smith, Clare Brown, Christina Jones, Mark Davies
A396 CCL22 miRNA modulated Th1 responses and induced therapeutic effects on OVA-induced mouse model of asthma
Won Suck Yoon
A397 Clinical, Histological, and Skin Microbiome Characteristics of Head and Neck Dermatitis in Atopic Dermatitis
Hemin Lee, Howard Chu, Jungsoo Lee, Jung U Shin, Chang Ook Park, Kwang Hoon Lee, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim
A398 MicroRNA-432 modulates Th1 responses and induced therapeutic effects in atopic like murine model.
Won Suck Yoon
A399 Case Report of Near-Fatal Asthma Due to Snail Allergy in a House Dust Mite-Allergic Adult
Jean-Pierre L’huillier, Jean-Eric Autegarden, Catherine Bertrand, Dominique Tardy
A400 Relationship Between Gut Microbiota in the First 3 Months of Life and Infant Immune Function at Age 12 Months
Intan Hakimah Ismail, Mimi Tang, Paul Licciardi, Frances Oppedisano, Robert Boyle, Roy Robins-Browne
A401 A Pediatric Case of Food-Dependent Exercise-Induced Anaphylaxis Due to Spice Allergy
Hisako Yagi, Harumi Koyama, Yutaka Nishida, Takumi Takizawa, Hirokazu Arakawa
A402 Correlations Between Objective Severity Score and Each of the Subjective Severity Intensity in Atopic Dermatitis
Hong Kyu Kang, Hemin Lee, Jungsoo Lee, Jung U Shin, Kwang Hoon Lee, Kwang Hoon Lee, Howard Chu, Chang Ook Park
A403 Barrier Related Gene Mutations in Atopic Dermatitis
Na Young Yoon, Hyeyoung Lee, Seong Jun Seo, Eunhee Choi, Hye-Young Wang, Minyoung Jung, Eung Ho Choi, Dong Hye Kim
A404 Clinical Utility of Basophil Activation Test (BAT) in the Diagnosis of Drug Induced Anaphylaxis
Joo-Hee KimYoung-Sook Jang, Jeong-Hee Choi, Sunghoon Park, Young Il Hwang, Seung Hun Jang, Ki-Suck Jung
A405 Feeding Shapes the Colonization of Gut Microbiota and Associated with Total IgE in Infant
Mi-Jin KangDongin Suh, Eun Lee, Kil Yong Choi, Young-Ho Jung, Song-I Yang, Bong-Soo Kim, Ha-Jung Kim, Juneyoung Koh, Hyun-Jin Kim, Kangmo Ahn, Youn Ho Shin, Hyun-Ju Cho, Byoung-Ju Kim, Young-Ho Kim, Yean Jung
A406 CD8+T Cell-Intrinsic Smad4 Suppresses Th2 Responses in the Pathogenesis of Contact Hypersensitivity
Mizuko Mamura, Jeong-Hwan Yoon, Susumu Nakae, Inkyu Lee, Isao Matsumoto, Takayuki Sumida, Jin Soo Han, Katsuko Sudo, Ji Hyeon Ju
A407 Immune-Modulatory Genomic Properties Differentiate Gut Microbiotas of Infants with and without Eczema
Gaik Chin Yap, Wen Tso Liu, Seungdae Oh, Pei Ying Hong, Chiung Hui Huang, Marion Aw, Lynette Shek, Bee Wah Lee
A408 The Effect of Medication in OSA Patients with Allergic Rhinitis
Young Seok Byun, Sung Wan Kim, Tae Kyung Koh, Joong-Saeng Jo, Kun Hee Lee, Chul Kwon, Sung-Hwa Dong
A409 A Case of Generalized Pustular Psoriasis Mimicking Acute Generalized Exanthematous Pustulosis
Myung Shin Kim, Chansun Park
A410 Anaphylaxis Caused By Gummy Jelly Ingestion: A Case Report
Han Seok Cho, Min-Ju Kim, Min Ji Kim, Young Ok Park, Hye Yeong Lee, Hee Seong Kim, Eun Lee, Hyun-Ju Cho, Jinho Yu, Soo-Jong Hong, Keum Hee Hwang
A411 Serum Folliculin As a Novel Biomarker for Asthma
Jung-Hyun Kim, You Sook Cho, Sae-Hoon Kim, Hyouk-Soo Kwon, Mira Yoo, Hyo-Jung Kim, So-Young Park, Bomi Shin, So Young Park, Bomi Seo, Min-Gu Kim, Hee-Bom Moon, Jin-Ah Park, Tae-Bum Kim, Jaemoon Lee
A412 Corticosteroid Nasal Irrigations after Endoscopic Sinus Surgery in the Management of Chronic Rhinosinusitis with Asthma
Jin Hyeok Jeong, Tae Wook Kang, Han Seok Yoo, Yong Hee Cho, Seok Hyun Cho, Kyung Rae Kim
A413 Capsaicin Injection in Neonatal Period Potentiates Intensity and Duration of Atopic Dermatitis of Rats.
Jue Seong Lee, Sun-Ho Kee, Sewon Kim, Young Yoo, Heung Sik Na, Seung Keun Back
A414 Comparison Between the Impulse Oscillometry System, Spirometry, Feno, Lung Clearance Index and Asthma Control and Exacerbation Status.
Seung Jin Lee, Bo Seon Seo, Ji Hyeon Baek, Kyung Suk Lee, Young-Ho Jung, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Mi-Ae Kim
A415 The Association of Exhaled Nitric Oxide and Airway Hyperresponsiveness in Patients with and without Asthma
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A416 Effects of Air Pollution on Allergic Rhinitis in Korea
Jisun Park
A417 Exhaled Nitric Oxide in Korean Children with Allergic Rhinitis
Seung Hyun Moon
A418 A Questionnaire of Children with Asthma or Asthma and Allergic Rhinitis
Rong Jun Lin, Ren Zheng Guan
A419 A Case of Trimebutine-Induced Morbilliform Skin Eruption
Gyeong Yul Park, Hyun-Sun Yoon
A420 Comparison of Methacholine and Mannitol to Predict Exercise-Induced Bronchoconstriction in Children with Asthma
Woo-Hyeok Choi, Heysung Baek
A421 Different Inflammatory Mechanisms of Human Metapneumovirus and Respiratory Syncytial Virus
Jin-Sung Park, Eunmi Kwon, Zac Callaway, Chang-Keun Kim, Takao Fujisawa
A422 Sputum Microbiota in Chinese Adults with Eosinophilic Versus Non-Eosinophilic Asthma
Qingling Zhang, Rihuang Qiu, Naijian Li, Zhaowei Yang, Jing Li, Kian Fan Chung, Nanshan Zhong
A423 Which Clinical Features Are Useful in Predicting Presence of Staphylococcus Aureus colonization/Infection in Childhood Atopic Dermatitis?
Kam Lun E. Hon, Yin Ching K. Tsang, Ting Fan Leung
A424 Clinical Significance of Increased VEGF, TGF-Î21, and YKL-40, a Chitinase like Protein, in Serum of the Children with Asthma
Yoon Young Jang, Hai Lee Chung, Seung Gook Lee, Ji Hyun Na, Jong Hoon Lee
A425 Analysis of Follow-up Results of Mannitol Challenge Test in Asthma Patients
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A426 Analysis of 68 Oral Walnut Challenge Tests
Mikita Yamamoto, Sakura Sato, Noriyuki Yanagida, Ayako Ogawa, Kanako Ogura, Kyohei Takahashi, Kenichi Nagakura, Shigehito Emura, Tomoyuki Asaumi, Katsuhito Iikura, Motohiro Ebisawa, Yu Okada
A427 Effectiveness of Air Filters Intervention in Allergic Rhinitis
Jiaying Luo, Xiao Lan, Baoqing Sun, Zhao Chen, Guiyuan Sun, Shimin Li, Jiaqing Hu
A428 The Relationship Between Airway Hyperresponsiveness to Mannitol and Atopy in Asthmatic Children
Woo-Hyeok Choi, Heysung Baek
A429 Anaphylactoid Reactions to N-Acetylcysteine in the Treatment of Aacetaminophen Overdose
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A430 Effect of Prenatal Maternal Distress and GSDMB Polymorphism on the Development of Recurrent Wheezing in Early Childhood: COCOA Study
Yean Jung Choi, Si Hyeon Lee, Young-Ho Kim, Mi-Jin Kang, Hyun-Ju Cho, Eun Lee, Song-I Yang, Youn Ho Shin, Kangmo Ahn, Kyung Won Kim, Yoon Hee Kim, So-Yeon Lee, Hyoung Yoon Chang, In Ae Choi, Kyung-Sook Lee, Yee-Jin Shin
A431 Vitamin D Level in Allergic Rhinitis: A Systemic Review and Meta-Analysis
Yoon Hee Kim, Min Jung Kim, In Suk Sol, Seo Hee Yoon, Young a Park, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Yong Ju Lee
A432 Implication of Inspiratory and Expiratory Resistance and Reactance in Children with Asthma
In Suk Sol, Kyu-Earn Kim, Yoon Hee Kim, Min Jung Kim, Seo Hee Yoon, Yong Ju Lee, Kyung Won Kim, Young a Park, Myung Hyun Sohn
A433 The Association of Asthma Predictive Index with Asthma in Preschool Children with Recurrent Wheeze
Sung Joo Park, Ji-Won Kwon, Woo Kyung Kim, Hyung Young Kim, Hyo-Bin Kim, Ju-Hee Seo, So-Yeon Lee, Gwang-Cheon Jang, Young-Ho Jung, Soo-Jong Hong, Byoung-Ju Kim, Dae-Jin Song, Yun Seok Yang, Jung Yeon Shim
A434 Clinical Significance of Serum Total IgE Levels in Children with RSV-Associated Lower Respiratory Illness
Yoon Young Jang, Hai Lee Chung, Ji Hye Kim, Hyun Seok Lee, Chang Ho Lee
A435 Development of a Oak Pollen Emission and Transport Modeling Framework in South Korea
Changbum Cho, Yun-Kyu Lim, Kyu Rang Kim, Mijin Kim, Baek-Jo Kim
A436 Temperature, Humidity, and Air Pollution Affect Atopic Dermatitis Symptoms in Infants and Young Children
Young-Min Kim, Youngshin Han, Jihyun Kim, Hae-Kwan Cheong, Byoung-Hak Jeon, Kangmo Ahn
A437 Effects of Compound V on Pulmonary Fibrosis Model
Chuang/Yao Ming, Jiu-Yao Wang, Ye/Yi Ling
A438 Vitamin D Level and the Correlation with IgE in Children with Allergic Respiratory Diseases in Guangzhou China
Huimin Huang, Baoqing Sun, Yun Chen, Peiyan Zheng, Nili Wei, Wenting Luo
A439 Two Case Reports of Eosinophilic Gastroenteritis Associated with Allergic Disease
Do Hyeong Lee, Gil-Soon Choi, Hee-Kyoo Kim, Han Su Park
A440 Genome-Wide Association Study (GWAS) May Identify Common Genetic Variations Both in Immediate and Delayed Drug
So-Young Park, Hyo-Jung Kim, Bomi Seo, Jung-Hyun Kim, Min-Gu Kim, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim, Yoon Su Lee
A441 Development of a Questionnaire for Secular Change of Atopic Dermatitis from Birth to 19-Year-Old.
Akio Tanaka, Satoshi Morioke, Yukihiro Ohya, Naoki Shimojo, Akira Akasawa, Michihiro Hide, Hiroko Shizukawa
A442 Evaluation of the Adherence Starts with Knowledge-20 (ASK-20) to Inhaled Drug in Patients with Bronchial Asthma
Naoto Watanabe
A443 The Epidemiology and Clinical Manifestation of Hmpv Infection in Children during Recent 4 Years: 2011-2014
Meeyong Shin, Myeong Sun Jang
A444 Neutropenia Induced By Intravenous Immunoglobulin
Young-Hee Nam, Yeo Myeong Noh, Dong Sub Jeon, Hee-Joo Nam, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A445 A First Case of Lymphocytic Interstitial Pneumonitis in Healthy Child
Ji-in Jung, Ha-Su Kim, Hyun-a Kim, Jin-a Jung
A446 Cytokine Production upon House Dust Mite Stimulation of Cord Blood Mononuclear Cells from Caesarean Section-Delivered Singaporean Infants
Anne Goh, Rajeshwar Rao, Bindu Nandanan, Ruurd Van Elburg, Chua Mei Chien, Juandy Jo, Johan Garssen, Johan Garssen, Leon Knippels, Elena Sandalova, Wen Chin Chiang
A447 Dress Syndrome with Acute Interstitial Nephritis Caused By Quinolone and Nonsteroidal Anti-Inflammatory Drugs
Young-Hee Nam, Ji Young Juong, Soo Jin Kim, Eun Young Kim, Su Mi Lee, Young Ki Son, Hee-Joo Nam, Ki-Ho Kim, Soo-Keol Lee
A448 IL-23 Roles in the Development of House Dust Mite Allergic Sensitization and Asthma
Da-Eun Park, Hye-Ryun Kang, Heung Woo Park, Hyun Seung Lee, Yoon-Seok Chang, Jung-Won Park, Sang-Heon Cho, Kyung-up Min, Woo-Jung Song
A449 Exposure Profile of Indoor Risk Factors in Dwellings of Children with Atopic Dermatitis
Hyunwook Lim, Sungchul Seo, Ji Tae Choung, Young Yoo, Jun-Sik Park, Byung Kwan Kim
A450 Epidemiological Characterization of Blood Eosinophils in the Elderly Population
Ha Kyeong Won, Hye-Ryun Kang, Byung-Keun Kim, Sung Do Moon, Ju-Young Kim, So-Hee Lee, Woo-Jung Song, Heung Woo Park, Min-Koo Kang, Sun-Sin Kim, Sang-Heon Cho, Kyung-up Min, Yoon-Seok Chang, Kyoung Hee Sohn, Kyung-Mook Kim, Ki-Woong Kim, Hak Chul Jang
A451 Stevens-Johnson Syndrome Caused By Methotrexate in the Treatment of Psoriasis
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A452 Genetic Determinants for Lung Function Growth in Asthmatic Children
Ting Fan Leung, Man Fung Tang, Hing Yee Sy, Wa Cheong Chan, Wilson Wai San Tam
A453 The Power of Allergen Specific Ig E in the Classification of Rhinitis, Korean National Hanes 2010
Seung Kyu Chung, Sujin Kim, Sang Duk Hong, Hyo Yeol Kim Hyo Yeol Kim, Hun-Jong Dhong, Jong in Jeong
A454 Analysis of Allergen Immunotherapy Practice and Patients’ Knowledge and Attitude about Allergen Immunotherapy in a Single Tertiary Hospital in Korea
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A455 Roles of Staphylococcal Enterotoxin B in House Dust Mite-Induced Acute Asthma Models
Ji Won Lee, Mingyu Kang, Soon-Hee Kim
A456 A Clinical Comparison of Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Single Tertiary Hospital in Korea
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A457 The Beneficial Effect of Lactobacillus Gasseri PM-A0005 and Its Immunoregulatory Protein PMA5P40 on Milk-Induced Allergic Enteritis
Yung-I Hou, Jiu-Yao Wang
A458 Relationship Between Serum Folate Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children’s Environmental Health Study
Ja Hyeong Kim, Seol Jae Hee, Eun-Hee Ha, Hyesook Park, Mina Ha, Yun-Chul Hong, Yangho Kim, Namsoo Chang
A459 Effects of Vitamin D in Patients with Chronic Rhinosinusitis
Yuta Soma, So Watanabe, Ruby Pawankar, Ruby Pawankar, Harumi Suzaki, Harumi Suzaki, Hitome Kobayashi
A460 Clinical Features of Systemic Contact Dermatitis from Ingestion of Rhus
Young-Hee Nam, Chansun Park, Soo-Keol Lee
A461 Sublingual Immunotherapy Efficacy in Patients with Atopic Dermatitis in Korea
Jongrok Lee, Jooyoung Roh, Haryeong Ryu
A462 Characteristics of Serious Adverse Drug Reactions in a Tertiary University Hospital
Cheol-Woo Kim, Jae Hwa Cho, Mi Ra Eom, Ji Young Kang, Hye Gyeung Lee
A463 Eyelid Dermatitis: Patch Test Results during a 15-Year Period in Korea and Evaluation of Metal Contents in Eye Shadows
Hae Young Choi, Hye Jin Lee, Ju Yun Woo, Ji Yeon Byun, You Won Choi
A464 Relationship Between Lipid Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children’s Environmental Health Study
Ja Hyeong Kim, Eun-Hee Ha, Hyesook Park, Mina Ha, Yun-Chul Hong, Yangho Kim, Namsoo Chang
A465 IL-32 in the Induced Sputum of Patients with Asthma
Jae-Woo Kwon, Hun Soo Chang, Jeong-Seok Heo, Jong-Uk Lee, Jong-Sook Park, Eusom Kim, Soo Hyun Kim, Choon-Sik Park
A466 Clinical Characteristics of Patients with Chromium Allergy in a Single University Hospital in Korea
Hae Young Choi, Ji Yeon Byun, Ju Yun Woo, You Won Choi
A467 Efficacy and Safety of Oral Acitretin in Chronic Hand Eczema
Hyun-Ju Jin, Jin-Hwa Son, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Margaret Song, Hyun-Chang Ko, Moon-Bum Kim, Hoon-Soo Kim, Byung Soo Kim
A468 Atypical Antipsychotics and Anticholinergic Agents Mimicking Anaphylaxis
Sheryl Van Nunen, Dinh Van Nguyen, Anthony Elias, Susannah Olivia Lauer
A469 Introducing Reach (Reliable Estimation of Atopic dermatitis in ChildHood): Novel, Questionnaire-Based Diagnostic Criteria for Childhood Atopic Dermatitis
Seung-Chul Lee, Ho-June Lee, Jung Min Bae
A470 Comprehensive Assessment to Identify the Causative Factors in Oral Allergy Syndrome
Emi Ono
A471 Comparison of Interpretation Methods in Allergic Skin Test
Sung-Hwa Dong, Tae Kyung Koh, Young Seok Byun, Sung Wan Kim, Joong-Saeng Jo, Chul Kwon, Kun Hee Lee
A472 Refraining Aminophylline Use Increases Hospitalization Among Children with Acute Asthma: A 10-Years Retrospective Cohort Study
Li-Fan Liu
A473 The Prevalence and Risk Factors of Atopic Dermatitis from Nationwide Study for Korean School Students
Sunghee Lee
A474 Probiotic Recombination Protein Effect on Atopic Dermatitis
Wei-Leng Chen, Jiu-Yao Wang
A475 Allergic Sensitization Status in Various Inflammatory Skin Diseases
Youin Bae, Gyeong-Hun Park
A476 Two Cases of Good’s Syndrome: A Rare Acquired Immunodeficiency Associated with Thymoma
Suk Yeon Kim
A477 IL-23 Has a Role to Play in the Development of Asthma in Short-Term Cigarette Smoke Exposure-Induced House-Dust Mite Allergic Model
Hyun Seung Lee, Woo-Jung Song, Mingyu Kang, Han-Ki Park, Da-Eun Park, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Hye-Young Kim, Kyung-up Min, Sang-Heon Cho, Ji-Won Lee, Boram Bae, Jung-Won Park
A478 The Relationship Between the Relevance of Allergic Disease and the Value of Non-Specific IgE
Yasuhiro Suzuki
A479 Two Caces of Prawn Allergy in Adult Patients
Ismet Bulut, Zeynep Ferhan Ozseker
A480 Early Gut Bifidobacterium Breve and B. Catenulatum Colonisation Differentially Modulate Eczema Risk in Children at High-Risk of Developing Allergic Disease
Intan Hakimah Ismail, Robert Boyle, Paul Licciardi, Frances Oppedisano, Roy Robins-Browne, Mimi Tang
A481 Effects of Chronic Repeated Exposure of Staphylococcal Enterotoxin B on Allergic Asthma Model in Mice
Ji Won Lee, Hyun Seung Lee, Mingyu Kang, Da-Eun Park, Han-Ki Park, Soon-Hee Kim, Woo-Jung Song, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Chang-Han Park, Suk-Il Chang, Sook-Hee Song, Kyung-up Min, Sang-Heon Cho, Boram Bae
A482 Skin Prick Test Result and Allergen Immunotherapy in Children with Allergic Rhinitis
Grace Shieh
A483 Role of Brp-39 in RSV-Induced Airway Inflammation in Mice
Min Jung Kim, Jung Yeon Hong, Seo Hee Yoon, Doo Hee Shim, In Suk Sol, Yoon Hee Kim, Mi Na Kim, Kyung Eun Lee, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Jae Myun Lee
A484 Long-Term Outcomes of Twenty-Four Adults with Primary Immunodeficiency from a Single Centre in Singapore
Hiok Hee Chng
A485 Breast Feeding Increases the Risk of Food Sensitization but Does Not Affect Food Allergy in Young Children with Atopic Dermatitis
Dong Chan Kim, Song-I Yang, Hae Ran Lee, An Deok Seo, So Yeon Lee
A486 IgE Immunoadsorption Knocks Down Anaphylaxis.
Alessandro Fiocchi, Maria Cristina Artesani, Paola Francalanci, Lamia Dahdah, Thomas Schreiner
A487 Burden and Correlates of Cigarette Smoking and Respiratory Airway Obstruction: An Observation in Urban Adult Population of West Bengal (India)
Kaushik Chakraborty
A488 Blood Eosinophils Could Predict Sputum Eosinophilia? : A Comparison Between Asthma and Non-Asthmatic Chronic Cough in the Elderly
Ha Kyeong Won, Ju-Young Kim, Eun-Jung Jo, Kyoung Hee Sohn, Kyung-Mook Kim, Heung Woo Park, Yoon-Seok Chang, Sang-Heon Cho, Woo-Jung Song, Byung-Keun Kim
A489 Complementary and Alternative Medicine for Allergic Rhinitis in Japan
Syuji Yonekura, Yoshitaka Okamoto
A490 Impact of Cognitive Impairment on Asthma Control Status in Elderly Asthmatics
Gyu Young Hur, Young Min Ye, Joo-Hee Kim, Ki-Suck Jung, Junga Kim, Jae Jeong Shim, Hae-Sim Park
A491 The Association Between Respiratory Tract Infection and Reactive Oxygen Stress
Kazuhiro Sekimoto, Kazuko Sugai, Keiji Tsuchimoto, Hiromi Uehara, Masanori Ikeda
A492 The Risk Factors and Lung Function of Current Allergic Rhinitis Due to Dust Mite Sensitization
Euncho Chung, Kang Seo Park, Yean Jung Choi, Jeewon Park, Soo-Jong Hong, So Yeon Lee
A493 Cloning and Expression of Recombinant Blomia Tropicalis Dust Mite Allergen Blo t 7
Alain Jacquet, Arun Buaklin, Nat Malainual
A494 Seasonal Variations of Airborne Pollen in Bangalore, India
Roopashree S
A495 Pollen Observation and Use of Data
Kyu Rang Kim, Mijin Kim, Changbum Cho, Baek-Jo Kim, Jae-Won Oh, Mae Ja Han
A496 The Effect of Cord Serum 25-Hydroxyvitamin D (25(OH)D) on the Development of Atopic Dermatitis in First 3 Years of Life : Cocoa Study
Hyun-Ju Cho, Youn Ho Shin, Eun Lee, Young-Ho Kim, Darae Lee, Mi-Jin Kang, Song-I Yang, Kangmo Ahn, Kyung Won Kim, Yoon Hee Kim, Hye-Sung Won, Soo Hyun Kim, Suk-Joo Choi, Young Han Kim, Jong Kwan Jun, Eun-Jin Kim, Jeom Gyu Lee, So-Yeon Lee, Soo-Jong Hong, Dongin Suh
A497 Contribution of Stem Cell Factor Autocrine/Paracrine Mechanism to Aberrant Proliferation of Mast Cells
Yosuke Amagai, Akane Tanaka, Hiroshi Matsuda
A498 A Randomized Dbpc Dose-Finding Multicenter Trial of Sublingual Immunotherapy (SLIT) Allergoid Tablets in House Dust Mites (HDM) Allergic Patients
Ralph Mösges, Pauline Dieterich, Anatoli Astvatsatourov, Christoph Hüser, Jaswinder Singh, Kija Shah-Hosseini, Silke Allekotte, Enrico Compalati
A499 Depression and Allergy in the Elderly: A Community Population Analysis
Kyoung Hee Sohn, Woo-Jung Song, Byung-Keun Kim, Ju-Young Kim, Min Suk Yang, So-Hee Lee, Sae-Hoon Kim, Hye-Ryun Kang, Heung Woo Park, Sun-Sin Kim, Kyung-up Min, Sang-Heon Cho, Yoon-Seok Chang
A500 The Integrated Analysis of Correlation Between Total IgE and Other Immunological Factors in Allergic Diseases
doi:10.1186/s40413-016-0096-1
PMCID: PMC4896250
25.  Tumor response assessment by the single-lesion measurement per organ in small cell lung cancer 
Background:
The criterion of two target lesions per organ in the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 is an arbitrary one, being supported by no objective evidence. The optimal number of target lesions per organ still needs to be investigated. We compared tumor responses using the RECIST 1.1 (measuring two target lesions per organ) and modified RECIST 1.1 (measuring the single largest lesion in each organ) in patients with small cell lung cancer (SCLC).
Methods:
We reviewed medical records of patients with SCLC who received first-line treatment between January 2004 and December 2014 and compared tumor responses according to the two criteria using computed tomography.
Results:
There were a total of 34 patients who had at least two target lesions in any organ according to the RECIST 1.1 during the study period. The differences in the percentage changes of the sum of tumor measurements between RECIST 1.1 and modified RECIST 1.1 were all within 13%. Seven patients showed complete response and fourteen showed partial response according to the RECIST 1.1. The overall response rate was 61.8%. When assessing with the modified RECIST 1.1 instead of the RECIST 1.1, tumor responses showed perfect concordance between the two criteria (k=1.0).
Conclusions:
The modified RECIST 1.1 showed perfect agreement with the original RECIST 1.1 in the assessment of tumor response of SCLC. Our result suggests that it may be enough to measure the single largest target lesion per organ for evaluating tumor response.
doi:10.21147/j.issn.1000-9604.2016.02.03
PMCID: PMC4865608  PMID: 27199513
Target lesion; Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1); modified Response Evaluation Criteria in Solid Tumors; tumor response 1.1 (modified RECIST 1.1); small cell lung cancer (SCLC)

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