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1.  The Effect of Open and Closed Kinetic Chain Exercises on Dynamic Balance Ability of Normal Healthy Adults 
[Purpose] This study investigated the effect of open and closed kinetic chain exercise on the dynamic balance ability of healthy young adults. [Subjects] Thirty-three healthy adults participated in this study. [Methods] Subjects were randomly assigned to either an open kinetic chain exercise group (n=17) or a closed kinetic chain exercise group (n=16). Both the open kinetic chain and closed kinetic chain exercise groups performed 3 sets of exercises 3 times per week for 6 weeks. Dynamic balance was measured at the beginning and end of the 6-week training period, including anterior-posterior, medial-lateral, and total displacement of the center of pressure. [Results] Both exercise groups showed improvement in balance parameters but the improvement was only statistically significant in the closed kinetic chain group. [Conclusion] Closed kinetic chain exercise appears to be more effective at improving of dynamic balance ability than open kinetic chain exercise within a 6-week training period.
PMCID: PMC3805008  PMID: 24259825
Open kinetic chain exercise; Closed kinetic chain exercise; Dynamic balance ability
2.  Sterol Carrier Protein-2: New roles in regulating lipid rafts and signaling 
Biochimica et biophysica acta  2007;1771(6):700-718.
Sterol carrier protein-2 (SCP-2) was independently discovered as a soluble protein that binds and transfers cholesterol as well as phospholipids (nonspecific lipid transfer protein, nsLTP) in vitro. Physiological functions of this protein are only now beginning to be resolved. The gene encoding SCP-2 also encodes sterol carrier protein-x (SCP-x) arising from an alternate transcription site. In vitro and in vivo SCP-x serves as a peroxisomal 3-ketoacyl-CoA thiolase in oxidation of branched-chain lipids (cholesterol to form bile acids; branched-chain fatty acid for detoxification). While peroxisomal SCP-2 facilitates branched-chain lipid oxidation, the role(s) of extraperoxisomal (up to 50% of total) are less clear. Studies using transfected fibroblasts overexpressing SCP-2 and hepatocytes from SCP-2/SCP-x gene-ablated mice reveal that SCP-2 selectively remodels the lipid composition, structure, and function of lipid rafts/caveolae. Studies of purified SCP-2 and in cells show that SCP-2 has high affinity for and selectively transfers many lipid species involved in intracellular signaling: fatty acids, fatty acyl CoAs, lysophosphatidic acid, phosphatidylinositols, and sphingolipids (sphingomyelin, ceramide, mono- di- and multi-hexosylceramides, gangliosides). SCP-2 selectively redistributes these signaling lipids between lipid rafts/caveolae and intracellular sites. These findings suggest SCP-2 serves not only in cholesterol and phospholipid transfer, but also in regulating multiple lipid signaling pathways in lipid raft/caveolae microdomains of the plasma membrane.
PMCID: PMC1989133  PMID: 17543577
Caveolae; lipid rafts; sterol carrier protein-2; SCP-2; phosphatidylinositol; sphingolipids; cholesterol; fatty acyl CoA; fatty acid
British Medical Journal  1924;2(3336):1078-1079.
PMCID: PMC2305438
British Medical Journal  1923;1(3260):1053.
PMCID: PMC2316548  PMID: 20771201

Results 1-7 (7)