The specific resting metabolic rates (Ki, in kcal/kg per day) of major organs and tissues in the Reference Man were suggested in 1992 by Elia: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for the residual mass. However, it is unknown whether gender influences the Ki values. The aim of the present study was to compare the Ki values observed in non-elderly non-obese men to the corresponding values in women.
Elia’s Ki values were evaluated based on a mechanistic model: REE = Σ(Ki × Ti), where REE is whole-body resting energy expenditure measured by indirect calorimetry and Ti is the mass of major organs and tissues measured by magnetic resonance imaging. Marginal 95% confidence intervals (CIs) for the model-estimated Ki values were calculated by stepwise univariate regression analysis. Subjects were non-elderly (age 20 - 49 yrs) non-obese (BMI 18.5 - 29.9 kg/m2) men (n = 49) and women (n = 57).
The measured REE (REEm) and the mass of major organs and skeletal muscle were all greater in the men than in women. The predicted REE by Elia’s Ki values were correlated with REEm in men (r = 0.87) and women (r = 0.86, both P <0.001). Elia’s Ki values were within the range of 95% CIs for both men and women groups, revealing that gender adjustment is not necessary.
Elia’s proposed adult Ki values are valid in both non-elderly non-obese men and women. Further studies are needed to explore the potential influences of age and obesity on Ki values in humans.