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Experimental and molecular pathology (1)
Bosmans, Frank (1)
Early, Merideth A. (1)
Gilchrist, John (1)
Gilchrist, John M. (1)
Gonzalez-Juarerro, Mercedes (1)
Higgins, David M. (1)
Lishnevsky, Marta (1)
Muller, William A. (1)
Orme, Ian M. (1)
Schenkel, Alan R. (1)
Year of Publication
Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9
Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine isoforms, Nav1.8 and Nav1.9 are preferentially expressed in DRG neurons where they are thought to play an important role in pain signaling. Although the functional properties of Nav1.8 have been relatively well characterized, difficulties with expressing Nav1.9 in established heterologous systems limit our understanding of the gating properties and toxin pharmacology of this particular isoform. This review summarizes our current knowledge of the role of Nav1.8 and Nav1.9 in pain perception and elaborates on the approaches used to identify molecules capable of influencing their function.
Nav1.8; Nav1.9; pain; animal toxins; voltage sensor; voltage-activated sodium channel
Non-invasive Diagnosis of Early Pulmonary Disease in PECAM Deficient Mice Using Infrared Pulse Oximetry
Early, Merideth A.
Higgins, David M.
Orme, Ian M.
Muller, William A.
Schenkel, Alan R.
Experimental and molecular pathology
Pulse oximetry is a common tool for detecting reduced pulmonary function in human interstitial lung diseases. It has not previously been used in a mouse model of interstitial lung disease. Further, Platelet Endothelial Cell Adhesion Molecule deficient mice rarely show symptoms until disease is advanced.
Using blood oxygen saturation, different stages of disease could be identified in a non-invasive manner. These stages could be correlated to pathology. Collagen deposition, using Picrosirius Red, did correlate with blood oxygen saturation. These studies are the first to show the use of an infrared pulse oximetry system to analyze the progression of a fibrotic interstitial lung disease in a mouse model of the human diseases. Further, these studies show that an early alveolar damage/enlargement event precedes the fibrosis in this mouse model, a stage that represents the best targets for disease analysis and prevention. This stage does not have extensive collagen deposition. Most importantly, targeting this earliest stage of disease for therapeutic intervention may lead to novel treatment for human disease.
PECAM; lung; fibrosis; blood; oxygen
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