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1.  Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer 
British Journal of Cancer  2012;107(1):137-142.
Background:
Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric cancer, especially in terms of its association with the staining pattern.
Methods:
Tissue specimens from 110 gastric cancer patients were immunohistochemically examined. The staining proportion and intensity of mesothelin expression in tumour cells were analysed, and the localisation of mesothelin was classified into luminal membrane and/or cytoplasmic expression.
Results:
Mesothelin was positive in 49 cases, and the incidence of mesothelin expression was correlated with lymph-node metastasis. Furthermore, luminal membrane staining of mesothelin was identified in 16 cases, and the incidence of luminal membrane expression was also correlated with pT factor, pStage, lymphatic permeation, blood vessel permeation, recurrence, and poor patient outcome. Multivariate analysis showed that luminal membrane expression of mesothelin was an independent predictor of overall patient survival.
Conclusion:
We described that the luminal membrane expression of mesothelin was a reliable prognostic factor in gastric cancer, suggesting the functional significance of membrane-localised mesothelin in the aggressive behaviour of gastric cancer cells.
doi:10.1038/bjc.2012.235
PMCID: PMC3389425  PMID: 22644300
mesothelin; luminal membrane expression; gastric cancer
2.  Contamination of blood pressure cuffs by methicillin-resistant Staphylococcus aureus and preventive measures 
Irish Journal of Medical Science  2013;182(4):707-709.
Background
Although blood pressure cuffs are commonly used and shared in medical facilities, their routine disinfection is performed infrequently.
Aims
We investigated the contamination of blood pressure cuffs by methicillin-resistant Staphylococcus aureus (MRSA).
Methods
The MRSA level on the inner side (the surface in contact with patients’ skin) of blood pressure cuffs used in the wards and outpatient clinics of a university hospital (733 beds) was determined using the gauze and swab wiping methods.
Results
Using the gauze wiping method (n = 35), the MRSA contamination rate was 31.4 %, and the MRSA contamination level was 1,702.6 ± 9,996.1 (0–58, 320) colony-forming units (cfu)/cuff. No MRSA was detected on blood pressure cuffs after washing (n = 30) or wiping with 80 vol% ethanol (n = 18).
Conclusions
Blood pressure cuffs are frequently contaminated by MRSA.
doi:10.1007/s11845-013-0961-7
PMCID: PMC3824197  PMID: 23639972
Blood pressure cuff; Contamination; Methicillin-resistant Staphylococcus aureus; MRSA
3.  Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma 
British Journal of Cancer  2011;105(1):131-138.
Background:
Cholangiocarcinoma (CC) is a highly malignant carcinoma. We attempted to clarify the prognostic significance of c-Met overexpression and its association with clinicopathological factors in patients with CC.
Patients and methods:
One hundred and eleven patients with intrahepatic CC (IHCC) and 136 patients with extrahepatic CC (EHCC) who had undergone curative surgery were divided immunohistologically into c-Methigh and c-Metlow groups. Clinicopathological factors and outcomes were compared between the groups. c-Met and epidermal growth factor receptor (EGFR) expression was also examined in 10 CC cell lines.
Results:
The positivity of c-Met was 45.0% in IHCC and 68.4% in EHCC; c-Methigh expression was demonstrated in 11.7% of IHCC and 16.2% of EHCC. c-Methigh expression was significantly correlated with the 5-year survival rate for CC overall (P=0.0046) and for IHCC (P=0.0013), histopathological classification in EHCC, and for EGFR overexpression in both IHCC and EHCC. Coexpression and coactivation of c-Met and EGFR were also observed in CC cell lines. Multivariate analysis revealed that c-Methigh expression was an independent predictor of poor overall and disease-free survival in patients with IHCC.
Conclusions:
c-Met overexpression is associated with EGFR expression and is a poor prognostic factor in CC.
doi:10.1038/bjc.2011.199
PMCID: PMC3137414  PMID: 21673683
c-Met; cholangiocarcinoma; immunohistochemistry; prognostic factor; epidermal growth factor receptor
5.  Induction of Graft Acceptance After Dog Kidney or Liver Transplantation 
Transplantation proceedings  1990;22(1):80-82.
We have reported that, a short delayed course of intramuscular FK 506 can induce a,donor strain-specific immunologic unresponsiveness to cardiac allograft in rats.1 Further studies have been performed to determine if this agent can induce graft acceptance after canine renal (KT) or hepatic (OLT) allotransplantation. Preliminary descriptions of these efforts have been published.2
PMCID: PMC3032582  PMID: 1689909

Results 1-25 (51)