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1.  Serum and parotid salivary IgA in chronic bronchitis and asthma 
Thorax  1974;29(3):313-316.
Siegler, D. I. M. and Citron, K. M. (1974).Thorax, 29, 313-316. Serum and parotid salivary IgA in chronic bronchitis and asthma. It has been suggested that immunoglobulin A (IgA) deficiency may be an important predisposing factor to infection in chronic bronchitis and that this occurs more often in extrinsic asthmatics than in normal subjects. These claims have been investigated by measurement of IgA in stimulated parotid saliva and serum in chronic bronchitics and asthmatics. Salivary and serum IgA levels in 84 chronic bronchitics could not be correlated with sputum purulence, the degree of ventilatory impairment, radiographic evidence of emphysema or the smoking history. Serum IgA was low in 6% and salivary IgA was normal in all cases. IgA levels measured in both serum and saliva in 50 asthmatics showed no correlation with the number of positive skin tests or other evidence of atopy. Serum IgA was low in 8% and salivary IgA was normal in all cases.
PMCID: PMC470151  PMID: 4854254
3.  Tuberculosis among the homeless at a temporary shelter in London: report of a chest x ray screening programme. 
STUDY OBJECTIVE--To estimate the prevalence of active pulmonary tuberculosis in a homeless population in London and to assess whether those with suspected disease could be integrated into the existing health care system for further follow up and treatment. DESIGN--Voluntary screening programme based on a questionnaire survey and chest x ray. SETTING AND CASES--Screening programmes were set up over the Christmas period in 1992 and 1993 at a shelter for the homeless in London. An offer of screening was made to all individuals who visited the centre and an interviewer administered questionnaire was completed on those who volunteered for the screening. Chest x rays were carried out, developed, and read on site. Individuals with chest x rays features suggestive of tuberculosis or other medical problems were referred to a hospital of their choice. RESULTS AND OUTCOME--In 1992 nearly 1600 people visited the centre, of whom 372 volunteered for the screening and 342 were x rayed. Nineteen of the 342 (5.6%) had radiological features suggestive of active tuberculosis. In 1993 around 2000 homeless people visited the centre, of whom 270 volunteered for the screening and 253 were x rayed. Eleven (4.3%) had features consistent with active tuberculosis on the basis of the chest x rays and clinical examination by a chest physician. Overall, of 595 people x rayed in the two surveys, 30 (5%) had changes suggestive of active tuberculosis. Further investigations confirmed nine (1.5%) with active pulmonary disease and eight with no active tuberculosis. In 13, the diagnosis was not determined as four declined further investigation and nine did not attend their hospital appointment. CONCLUSION--Tuberculosis among the homeless remains a cause for concern. Follow up and treatment present unique difficulties. Services for the homeless need to include mechanisms for timely diagnosis and monitored treatment. Control programmes designed for the needs of the homeless are required.
PMCID: PMC1060180  PMID: 8596100
5.  Trends in tuberculosis. 
Postgraduate Medical Journal  1984;60(701):187-193.
PMCID: PMC2417768  PMID: 6709559
6.  Introduction 
Postgraduate Medical Journal  1984;60(701):177.
PMCID: PMC2417765
7.  Large lung bullae in sarcoidosis. 
Thorax  1986;41(10):792-797.
Large lung bullae are a rare manifestation of pulmonary sarcoidosis. Of three patients with this complication, all had pulmonary infiltrates at presentation and two had bilateral hilar adenopathy. Hypercalcaemia developed during the course of the illness in all three patients. In each case the bullae had developed within four years of the diagnosis of sarcoidosis. In one woman a bulla resolved almost completely after it had become infected.
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PMCID: PMC460490  PMID: 3787510
8.  Staffing in thoracic medicine. 
British Medical Journal  1980;281(6244):887-888.
PMCID: PMC1714270  PMID: 7427495
9.  Mucociliary clearance in patients with chronic autonomic failure. 
Thorax  1980;35(9):690-693.
Mucociliary clearance was measured in four patients with chronic autonomic failure and normal ventilatory function using a method of scanning the clearance of inhaled polystyrene particles tagged with 99mTc. Previous surgical and experimental evidence has suggested that autonomic denervation might be expected to impair clearance. However, the four patients in this study showed no significant difference in clearance rate compared to groups of sex-matched control subjects. A fifth patient was found to have impaired mucociliary clearance. However she had the symptoms and ventilatory function of smoking-related chronic obstructive bronchitis, a condition which has previously been shown to impair mucociliary clearance.
PMCID: PMC471363  PMID: 7444841
10.  Tuberculosis. 
British Medical Journal  1973;2(5861):296-298.
PMCID: PMC1589143  PMID: 4122247
11.  Tuberculosis--chemotherapy. 
British Medical Journal  1972;1(5797):426-428.
PMCID: PMC1787330  PMID: 4109997
12.  Primary immunity deficiency in adults. 
Thorax  1970;25(2):254-255.
PMCID: PMC472157  PMID: 5441998
13.  Home Treatment of Pulmonary Tuberculosis 
British Medical Journal  1966;1(5488):657-659.
PMCID: PMC1843935  PMID: 5908714
14.  Early Diagnosis of Pulmonary Tuberculosis 
British Medical Journal  1966;1(5487):589-591.
PMCID: PMC1843875  PMID: 5907318
15.  Controlled Trial of Prophylactic Penicillin in Thoracic Surgery 
Thorax  1965;20(1):18-20.
PMCID: PMC1018889  PMID: 14255479
19.  Stenosing Non-caseating Tuberculosis (Sarcoidosis) of the Bronchi 
Thorax  1957;12(1):10-17.
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PMCID: PMC1019291  PMID: 13422391
20.  Are healthcare workers in England and Wales at increased risk of tuberculosis? 
BMJ : British Medical Journal  1996;313(7056):522-525.
OBJECTIVE: To determine whether healthcare workers in England and Wales are at increased risk of tuberculosis and to examine the frequency of drug resistance in this population. DESIGN: Comparison of notification rates by occupation obtained from national tuberculosis notification surveys in 1988 and 1993, with denominators from the 1991 census. SUBJECTS: People with notified tuberculosis in professional and associate professional occupations from the two surveys. MAIN OUTCOME MEASURES: Rates of notified tuberculosis in health professionals (mainly doctors) and health associate professionals (mainly nurses) compared with rates in other professional and associate professional occupations, adjusted for ethnic group, sex, and age. RESULTS: 119 cases of tuberculosis were identified in healthcare workers, including 61 nurses and 42 doctors. The crude notification rate in healthcare workers was 11.8 per 100,000 per year (95% confidence interval 9.8 to 14.1) compared with 3.3 per 100,000 per year (2.9 to 3.6) in other professional and associate professional occupations; rate ratios were higher (range 1.7 to 3.2) in all ethnic groups. The relative risk adjusted for ethnic group, sex, and age was 2.4 (95% confidence interval 2.0 to 3.0), slightly higher for health professionals (2.7 (1.9 to 3.8)) than for associate professionals (2.0 (1.5 to 2.6)). No multiple drug resistant strains of tuberculosis were identified in healthcare workers. CONCLUSIONS: Better detection and notification of cases of tuberculosis in healthcare workers may account for some of the apparent increased risk, but these findings imply that tuberculosis remains a hazard for healthcare workers and highlight the importance of ensuring that occupational health monitoring and protection workers are not neglected.
PMCID: PMC2351896  PMID: 8789976
22.  Immunisation against infectious disease. 
BMJ : British Medical Journal  1988;297(6660):1406.
PMCID: PMC1835095  PMID: 3146387
24.  Ocular toxicity from ethambutol. 
Thorax  1986;41(10):737-739.
PMCID: PMC460464  PMID: 3787505

Results 1-25 (42)