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1.  Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures 
The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth.
doi:10.1007/s10856-011-4256-0
PMCID: PMC3085057  PMID: 21327405
2.  Frictional and bone ingrowth properties of engineered surface topographies produced by electron beam technology 
Background
Electron beam melting (E-beam) is a new technology to produce 3-dimensional surface topographies for cementless orthopedic implants.
Methods
The friction coefficients of two newly developed E-beam produced surface topographies were in vitro compared with sandblasted E-beam and titanium plasma sprayed controls. Bone ingrowth (direct bone–implant contact) was determined by implanting the samples in the femoral condyles of 6 goats for a period of 6 weeks.
Results
Friction coefficients of the new structures were comparable to the titanium plasma sprayed control. The direct bone–implant contact was 23.9 and 24.5% for the new surface structures. Bone–implant contact of the sandblasted and titanium plasma sprayed control was 18.2 and 25.5%, respectively.
Conclusions
The frictional and bone ingrowth properties of the E-beam produced surface structures are similar to the plasma-sprayed control. However, since the maximal bone ingrowth had not been reached for the E-beam structures during the relatively short-term period, longer-term follow-up studies are needed to assess whether the E-beam structures lead to a better long-term performance than surfaces currently in use, such as titanium plasma spray coating.
doi:10.1007/s00402-010-1218-9
PMCID: PMC3078515  PMID: 21161665
Electron beam melting; Bone ingrowth; Friction; Surface characteristics; Prosthesis

Results 1-2 (2)