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1.  Synthesis, characterization and biological evaluation of dihydropyrimidine derivatives 
A series of dihydropyrimidines containing quinoline were prepared under conventional heating and microwave irradiation. The structures of newly synthesized compounds were established based on analytical and spectral studies. Further these compounds were evaluated for their antioxidant, antifungal and antibacterial activities. Most of the compounds showed moderate to good activity when compared with standard.
PMCID: PMC3744957  PMID: 23960779
Quinolinodihydropyrimidines; MW assisted synthesis; Three component reaction; Antioxidant activity; Antibacterial activity; Antifungal activity
2.  (E)-3-Methyl-4-[(2-oxidoquinolin-1-ium-3-yl)methyl­eneamino]-1H-1,2,4-triazole-5(4H)-thione N,N-dimethyl­formamide solvate 
The title 1,2,4-triazole compound, C13H11N5OS·C3H7NO, crystallizes as a 1:1 dimethyl­formamide (DMF) solvate. The main mol­ecule exists in a trans configuration with respect to the acyclic C=N bond. An intra­molecular C—H⋯S hydrogen bond generates an S(6) ring motif. In the synthesis, a proton is transferred from the O atom of a hydr­oxy group to the quinoline group N atom. The essentially planar triazole ring and quinoline ring system [maximum deviations of 0.001 (2) and 0.013 (2) Å, respectively] form a dihedral angle of 5.86 (9)°. In the crystal structure, mol­ecules of (E)-4-[(2-hydroxy-3-­quinolyl)methyl­eneamino]-3-methyl-1H-1,2,4-triazole-5(4H)-thione are linked into R 2 2(8) centrosymmteric dimers via N—H⋯O hydrogen bonds. These dimers are further linked into an extended three-dimensional structure by the DMF solvent mol­ecules via inter­molecular N—H⋯O and C—H⋯O hydrogen bonds. The crystal structure is consolidated by two different inter­molecular π–π inter­actions [centroid–centroid distances = 3.6593 (12) and 3.6892 (12) Å].
PMCID: PMC2972175  PMID: 21578940
3.  5-Bromo-2-[5-(4-nitro­phen­yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]pyrimidine 
In the title pyrazoline compound, C19H14BrN5O2, the essentially planar pyrazoline and pyrimidine rings [maximum deviations = 0.013 (1) and 0.009 (1) Å, respectively] are inclined slightly to one another, making a dihedral angle of 10.81 (10)°. The nitro­benzene unit is almost perpendicular to the attached pyrazoline ring, as indicated by the dihedral angle of 84.61 (8)°. In the crystal structure, inter­molecular C—H⋯N contacts link the mol­ecules into dimers in an anti­parallel manner. These dimers are further linked into one-dimensional chains along the b axis via C—H⋯O contacts. The crystal structure is consolidated by three different inter­molecular π–π inter­actions [range of centroid–centroid distances = 3.5160 (11)–3.6912 (11) Å].
PMCID: PMC2972095  PMID: 21578856
4.  4-Hydrazino-2-(methyl­sulfan­yl)­pyrimidine 
In the crystal of the title compound, C5H8N4, centrosymmetric dimers are linked by pairs of N—H⋯N hydrogen bonds. Further N—H⋯N links result in a two-dimensional array whereby wave-like supra­molecular chains are inter­connected by R 2 2(8) ring motifs.
PMCID: PMC2968169  PMID: 21582010
5.  Ethyl 2-[(E)-4-(dimethyl­amino)benzyl­idenehydrazino]-5-nitro­benzoate 
The title compound, C18H20N4O4, exists in the E configuration with respect to the C=N bond of the methyl­idine unit. The dihedral angle between the two benzene rings is 9.01 (6)°. An intra­molecular N—H⋯O hydrogen bond involving the benzoate unit generates an S(6) ring motif. In the crystal, the mol­ecules are linked by weak C—H⋯O inter­actions into infinite chains along the b axis. These chains are further connected into sheets parallel to the ab plane which are stacked approximately along the c axis. A C—H⋯π inter­action is also observed.
PMCID: PMC2959927  PMID: 21581265

Results 1-5 (5)