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author:("abol, Pankaj")
1.  Parathyroid and Calcium Status in Patients with Thalassemia 
Thirty patients with thalassemia major receiving repeated blood transfusion were studied to see their serum parathyroid hormone (PTH) and calcium status. Serum PTH, serum and 24 h urinary calcium, and serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were determined. Half of these patients, in addition to transfusion, were also supplemented with vitamin D (60,000 IU for 10d) and calcium (1500 mg/day for 3 months). Serum PTH, and serum and 24 h urinary calcium concentrations of the patients receiving transfusions were found to be significantly reduced while their serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were not significantly altered when compared to the respective mean values for the control group. Vitamin D and calcium supplementation significantly increased their serum PTH and calcium levels. Supplementations also increased urinary excretion of calcium. The results thus suggest that patients with thalassemia have hypoparathyroidism and reduced serum calcium concentrations that in turn were improved with vitamin D and calcium supplementation.
doi:10.1007/s12291-010-0071-5
PMCID: PMC2994558  PMID: 21966110
Parathyroid hormone; Calcium; Thalassemia
2.  Effect of vitamin A supplementation on hematopoiesis in children with anemia 
Fifty children (1–4 years age) presenting with microcytic hypochromic anemia (hemoglobin less than 10g/dl) were studied in two groups of 25 each. Group I was supplemented with iron (ferrous sulphate 6 mg/kg/d) while group II in addition to iron was also supplemented with vitamin A (5000 IU/d). Hemoglobin concentration was found to be significantly increased after 4 weeks of iron supplementation. Rise in hemoglobin was comparatively more in-group II, as compared to group I, after 8 and 12 weeks. Serum iron was significantly higher after 4 weeks in both the groups. Packed cell volume (PCV) and retinol levels increased significantly in-group II only. The data suggests that supplementation of vitamin A improves hematopoiesis.
doi:10.1007/BF02893048
PMCID: PMC3454151  PMID: 23105500
Vitamin A; Hematopoiesis; Anemia
3.  Vitamin a status in children with diarrhoea 
Vitamin A status was measured in 50 pre-school children with acute and persistent diarrhoea. It was measured by (a) Fluorometric micromethod and (b) Conjunctival impression cytology (CIC). The results were compared with 25 normal children. Vitamin A status was lower in children with persistent diarrhoea whereas the results were comparable between the children with acute diarrhoea and control subjects.
doi:10.1007/BF02867944
PMCID: PMC3453709  PMID: 23105339
Vitamin A; Acute diarrhoea; Persistent diarrhoea
4.  Thyroid hormone status in protein energy malnutrition in Indian children 
Thyroid hormonal status was measured in 80 malnourished children of different grades (I–IV) of protein energy malnutrition (PEM). Serum levels of tri-iodo thyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) were measured by radioimmunoassay. The results were compared with 20 healthy, age and sex matched controls. Levels of T3 and T4 were significantly low in PEM cases whereas TSH levels were similar in PEM cases when compared to controls.
doi:10.1007/BF02864867
PMCID: PMC3453633  PMID: 23105324
Thyroid hormones; Protein energy malnutrition
5.  Vitamin E status in protein energy malnutrition 
Serum vitamin E and cholesterol concentrations were measured in 50 children with protein energy malnutrition (PEM) and results were compared with a group of 50 normal controls. Mean serum vitamin E concentration as well as vitamin E/cholesterol ratio were found to be reduced in children with PEM while their mean serum cholesterol level was not significantly different from the control group. Data suggest that the reduced levels of serum vitamin E in PEM may be a result of malnutrition per se.
doi:10.1007/BF02873675
PMCID: PMC3453677  PMID: 23100878
Vitamin E; Cholesterol; PEM

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