PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-25 (1031758)

Clipboard (0)
None

Related Articles

2.  Sir Henry Dale, O.M., 85 
British Medical Journal  1960;1(5188):1803-1804.
Images
PMCID: PMC1967772
3.  Sir Henry Dale 90 
British Medical Journal  1965;1(5448):1450.
Images
PMCID: PMC2166673  PMID: 20790547
4.  Histamine and Sir Henry Dale 
British Medical Journal  1965;1(5448):1488-1490.
Images
PMCID: PMC2166627  PMID: 14288090
8.  The differential transmissibility of Myxoma virus strains of differing virulence grades by the rabbit flea Spilopsyllus cuniculi (Dale). 
The Journal of Hygiene  1975;75(2):237-247.
Laboratory studies showed that few rabbit fleas (Spilopsyllus cuniculi (Dale)) transmitted myxomatosis after removal from wild rabbits (Oryctolagus cuniculus (L) that had been infected for fever than 10-12 days, irrespective of the virulence of the myxoma virus strain involved. Rabbits infected with fully virulent (Grade I) strains died within 10-15 days and few fleas from these hosts became infective; averaging all the samples takem. 12% of the fleas were infective. Also, few fleas acquired infectivity on individual rabbits which covered from infection with attenuated strains; the mean was 8% infective. Rabbits which died between 17 and 44 days after infection had higher proportions of infective fleas at all sampling times; the mean was 42% infective. Male and female fleas transmitted virus with equal efficiency. For rabbits infected with any of the attenuated virus strains the mean percentage of infective fleas was inversely related to the survival time of the host. Rabbits infected with moderately attenuated strains (Grades IIIA and IIIB) had, on average, the highest proportion of infective fleas; hence such strains have a selective advantage and have become predominant under natural conditions in Britain. The changes that might occur if there is an increase in host resistance to myxomatosis are discussed.
Images
PMCID: PMC2130293  PMID: 1058245
9.  Laboratory breeding of the European rabbit flea, Spilopsyllus cuniculi (Dale). 
The Journal of Hygiene  1979;83(3):521-530.
A method is described for the laboratory breeding of the rabbit flea in which the immature stages are reared at constant temperature and humidity. Eggs are obtained by confining fleas taken from a rabbit and her nest shortly after parturition with two of her nestlings in an incubator for 24 h. The eggs are transferred to an artificial diet medium on which the immature stages are reared. On average a female flea produces 50 eggs during the first six days post-partum. At 25 degrees C, 95% of eggs hatched at 79% RH and 98% at 84% RH. Most eggs hatched on the third day after laying and hatching was completed by the fourth day. Significantly more fleas of both sexes were obtained when larvae were reared at 25 degrees C on a medium containing powdered 41B rodent diet than on one containing terrier meal. Both diets also contained yeast and dried rabbit blood. There was no significant difference between the numbers of fleas obtained at 79% RH and 84% RH. Significantly more fleas were also obtained when larvae were reared at 27 degrees C, 84% RH, than at 25 degrees C. Female fleas emerged sooner than males at both 27 degrees C and 25 degrees C. Fleas from the laboratory culture were heavier than those from wild nests. Female fleas were heavier than male fleas in both cases.
PMCID: PMC2130157  PMID: 512357
10.  Macquarie Island: the introduction of the European rabbit flea Spilopsyllus cuniculi (Dale) as a possible vector for myxomatosis 
The Journal of Hygiene  1973;71(2):299-308.1.
The European rabbit flea Spilopsyllus cuniculi (Dale) was first released on Macquarie Island in December 1968. The flea has survived and bred on the island and about 30% of the rabbits sampled from the original release area in January 1972 were flea-infested.
Images
PMCID: PMC2130493  PMID: 4515880
11.  What's in a name? Henry Dale and adrenaline, 1906. 
Medical History  1995;39(4):459-476.
PMCID: PMC1037030  PMID: 8558993
13.  Sir Henry Dale 
British Medical Journal  1968;3(5613):261-262.
PMCID: PMC1986261  PMID: 20791530
16.  The Henry Dale Professorship 
British Medical Journal  1961;1(5241):1746.
PMCID: PMC1954364  PMID: 20789168
17.  Sir Henry Dale, O.M 
British Medical Journal  1965;1(5449):1557.
PMCID: PMC2166726
18.  Henry Ridley Dale 
British Medical Journal  1889;2(1506):1072.
PMCID: PMC2155797
19.  Sir Henry Dale, P.R.S 
British Medical Journal  1940;2(4170):791.
PMCID: PMC2179982  PMID: 20783436
21.  Sir Henry Dale 
British Medical Journal  1955;1(4926):1378-1379.
PMCID: PMC2062160  PMID: 14363904
22.  Sir Henry Dale's Opus 
British Medical Journal  1953;1(4825):1436-1437.
PMCID: PMC2016634  PMID: 13042293
24.  Sir Henry Dale, M. D. (1875-1968). 
PMCID: PMC2312287  PMID: 4901736
25.  Make it better but don't change anything 
With massive amounts of data being generated in electronic format, there is a need in basic science laboratories to adopt new methods for tracking and analyzing data. An electronic laboratory notebook (ELN) is not just a replacement for a paper lab notebook, it is a new method of storing and organizing data while maintaining the data entry flexibility and legal recording functions of paper notebooks. Paper notebooks are regarded as highly flexible since the user can configure it to store almost anything that can be written or physically pasted onto the pages. However, data retrieval and data sharing from paper notebooks are labor intensive processes and notebooks can be misplaced, a single point of failure that loses all entries in the volume. Additional features provided by electronic notebooks include searchable indices, data sharing, automatic archiving for security against loss and ease of data duplication. Furthermore, ELNs can be tasked with additional functions not commonly found in paper notebooks such as inventory control. While ELNs have been on the market for some time now, adoption of an ELN in academic basic science laboratories has been lagging. Issues that have restrained development and adoption of ELN in research laboratories are the sheer variety and frequency of changes in protocols with a need for the user to control notebook configuration outside the framework of professional IT staff support. In this commentary, we will look at some of the issues and experiences in academic laboratories that have proved challenging in implementing an electronic lab notebook.
doi:10.1186/1759-4499-1-5
PMCID: PMC2810290  PMID: 20098591

Results 1-25 (1031758)