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Ancient Science of Life  1985;5(1):49-53.
The Ayurvedic materia medica is based upto 500 to 600 plant drugs. The number of these drugs are dwindling rapidly due to several natural and man made factors with the result the physicians are uanble to get the required drug or the required quantity of the drug. This ultimately results in the gradual death of the entire system. In order to overcome this alarming problem and to provide a permanent solution, various aspects like new or alternate sources for the drugs, exploitation of crude drug market sources, ethnobotanical data and cultivation and germ plasm are discussed in detail.
PMCID: PMC3331444  PMID: 22557500
Ancient Science of Life  1990;9(4):191-201.
Nearly two hundred Ayurvedic drugs of plant origin have bee introduced in he Unani material medica, the names of most of the drugs have been adopted from Indian languages per se.
PMCID: PMC3331336  PMID: 22557697
3.  Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes 
Molecular Ecology Resources  2014;15(2):358-371.
DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes.
PMCID: PMC4344822  PMID: 24961287
Angelica; authentication; decoction pieces; DNA barcodes; materia medica
4.  Stability and Accuracy Assessment of Identification of Traditional Chinese Materia Medica Using DNA Barcoding: A Case Study on Flos Lonicerae Japonicae 
BioMed Research International  2013;2013:549037.
DNA barcoding is a novel molecular identification method that aids in identifying traditional Chinese materia medica using traditional identification techniques. However, further study is needed to assess the stability and accuracy of DNA barcoding. Flos Lonicerae Japonicae, a typical medicinal flower, is widely used in China, Korea, and other Southeast Asian countries. However, Flos Lonicerae Japonicae and its closely related species have been misused and traded at varying for a wide range of prices. Therefore, Flos Lonicerae Japonicae must be accurately identified. In this study, the ITS2 and psbA-trnH regions were amplified by polymerase chain reaction (PCR). Sequence assembly was performed using CodonCode Aligner V 3.5.4. The intra- versus inter-specific variations were assessed using six metrics and “barcoding gaps.” Species identification was conducted using BLAST1 and neighbor-joining (NJ) trees. Results reveal that ITS2 and psbA-trnH exhibited an average intraspecific divergence of 0.001 and 0, respectively, as well as an average inter-specific divergence of 0.0331 and 0.0161. The identification efficiency of ITS2 and psbA-trnH evaluated using BLAST1 was 100%. Flos Lonicerae Japonicae was formed into one clade through the NJ trees. Therefore, Flos Lonicerae Japonicae can be stably and accurately identified through the ITS2 and psbA-trnH regions, respectively.
PMCID: PMC3687729  PMID: 23862147
6.  European Materia Medica in Historical Texts: Longevity of a Tradition and Implications for Future Use 
Journal of ethnopharmacology  2010;132(1):28-47.
Recent research in the area of new drug discovery has shown the continued promise of looking to natural products for bioactive compounds. Researchers have thus turned to traditional medicine, which is still used widely throughout the world and increasingly in industrialized countries as well, to provide clues as to which products to investigate. The oral traditions on which much of this medical knowledge rests, however, are unstable, prompting researchers to turn to textual sources for potential drugs. This study uses Mediterranean/European medical texts from the 5th century BC to the 19th century A.D. to compile a list of the most commonly used “simples” – or single action drug substances – used in therapeutics in traditional European medicine. It finds that traditional European materia medica was based on a Dioscordean tradition that lasted through the 19th century with remarkably little variation, but is significantly different from the present-day herbal pharmacopoeia as represented by the National Institutes of Health. The most prominent simples of that tradition can thus provide clues to further bioactive compounds that have not as of yet been fully exploited for their potential, but were clearly of great use in the past.
PMCID: PMC2956839  PMID: 20561577
materia medica; new drug discovery; Dioscorides; history; traditional medicine; bioprospecting
7.  Effects of Chinese Materia Medica-Fubao Danggui Jiao on Experimental Endometriosis 
The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.
PMCID: PMC3252223  PMID: 22468001
Fubao Danggui Jiao; Chinese Materia Medica; Endometriosis; Danazol
8.  Materia Socio Medica is Indexed in Pubmed and Archived in PubMed Central 
Materia Socio-Medica  2013;25(1):4-5.
Materia Socio Medica Journal has been accepted for archiving in PubMed Central from 2011. The journal started in 1993 as offi cial journal of Social Medicine Association of B&H. During last 3 years Mat Soc Med has included in almost all femous on-line databases (except WoS). All issues of Mat Soc Med published in 2012 are now visible on PubMed/PubMed Central.
PMCID: PMC3633487  PMID: 23678332
Materia Socio Medica; PubMed Central.
9.  Chinese Marine Materia Medica 
Marine Drugs  2014;12(1):193-195.
PMCID: PMC3917269
10.  De Materia Medica Versus Codex Alimentarius for the Reinforcement of the Gynecologic Immune System: the Case of Endometriosis 
Since the first Pharmacopoeia under the title “De Materia Medica,” the importance of the utilization of plants and herbs has been an invaluable medicinal tool successfully employed for strengthening the immune system for combating a number of diseases in general, or assisting fertility and reproductive issues in particular. The beneficial use of herbal extracts, constituting the basis of modern medicines, is lately under the shadow of Codex Alimentarius that threatens, if not properly applied, serious immunity features rendering the host defenseless for intercepting harmful invaders, one of which is the mesenchymal endometriotic stem cell causing endometriosis.
PMCID: PMC3941187  PMID: 24665212
Codex Alimentarius; endometriosis; immune system; reproductive issues; infertility; De Materia Medica

Results 1-25 (206092)