In November 2008, BMC Medicine passed the landmark of its first 5 years of publishing. When we launched the journal with the aim of publishing high quality research of general interest and special importance, we had no idea what the future would bring. To mark the occasion of our 5th anniversary, we consider the achievements of the last 5 years and discuss our plans for the future.
This review defines bioorganic chemistry as one of the most important constituents of
physico–chemical biology, which is a fundamental life science. The problems and goals of
bioorganic chemistry are examined through a comparatively small number of examples. Bioorganic
chemistry is supposed to be a logical continuation of the chemistry of the natural substances
that arose many years ago. Bioorganic chemistry has contributed some achievements in solving
the problems of the chemical structure, biological function, and physiological activity of
biopolymers and low–molecular–weight bioregulators, as well as in the elucidation
of the molecular mechanisms of different life processes. The most striking achievements in
bioorganic chemistry are discussed in this paper. However, this review discusses not only the
general achievements in this field of science, but also research data obtained by scientists
from the Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of
Sciences (Vladivostok, Russia), and the Institute of Physiology, Komi Science Centre, The Urals
Branch, Russian Academy of Sciences (Syktyvkar, Russia). Particular attention is focused on
comprehensive research into polysaccharides and biopolymers (bioglycans) and some natural
glycosides that the author of this review has studied for a long time. The author has worked in
these institutes for a long time and was honored by being chosen to head one of the scientific
schools in the field of bioorganic chemistry and molecular immunology.
bioglycans; natural glycosides; low-molecular-weight bioregulators
David Pimentel is a professor of ecology and agricultural sciences at Cornell University, Ithaca, NY 14853–0901. His Ph.D. is from Cornell University and had postdoctoral research at the University of Chicago, MIT, and fellowship at Oxford University (England). He was awarded a distinguished honorary degree from the University of Massachusetts. His research spans the fields of energy, population ecology, biological pest control, pesticides, sustainable agriculture, land and water conservation, livestock, and environmental policy. Pimentel has published more than 700 scientific papers and 37 books and has served on many national and government committees including the National Academy of Sciences; President’s Science Advisory Council; U.S Department of Agriculture; U.S. Department of Energy; U.S. Department of Health, Education and Welfare; Office of Technology Assessment of the U.S. Congress; and the U.S. State Department. He is currently Editorial Advisor for BMC Ecology. In this article, he reflects on 50 years since the publication of Rachel Carson’s influential book, Silent Spring.
The term extracellular matrix (ECM) has generated various associations throughout the history of medical research. While the spontaneously organizing fibers of connective tissue were originally thought to be the basis of life, the advent of the cellular concept by Rudolf Virchow put the ECM into the second line reducing their function to a mere scaffold and glue (“collagen”). Over the past decades our knowledge of the composition of the physiologic ECM has increased steadily and many possible interactions of several ECM components with cytokines and cell receptors have been discovered, making the ECM a promising target for improving the performance of biomaterials. The reviews in this Special Issue of Biomatter reflect the work of a Collaborative Research Center (TRR 67) of the Deutsche Forschungsgemeinschaft (DFG) based in Leipzig and Dresden, Germany, dedicated to matrix engineering in soft and hard tissues.
This review commemorates the 200th anniversary of Edward Jenner’s development of a vaccine for variola, the cause of smallpox, and the 20th anniversary of its eradication. Jenner’s original 23 case reports are briefly revisited within the context of earlier attempts to prevent this dreaded disease and in light of the current understanding of vaccinology and immunology. In addition, with molecular biological information available about many pox viruses and detailed sequence knowledge of some, it is now possible to appreciate Jenner’s prescient accomplishments more fully.
Edward Jenner; Pox viruses; Smallpox virus; Variolla; Vaccination
In 2009 the International Society for Computational Biology (ISCB) started to roll out regional bioinformatics conferences in Africa, Latin America and Asia. The open and competitive bid for the first meeting in Asia (ISCB-Asia) was awarded to Asia-Pacific Bioinformatics Network (APBioNet) which has been running the International Conference on Bioinformatics (InCoB) in the Asia-Pacific region since 2002. InCoB/ISCB-Asia 2011 is held from November 30 to December 2, 2011 in Kuala Lumpur, Malaysia. Of 104 manuscripts submitted to BMC Genomics and BMC Bioinformatics conference supplements, 49 (47.1%) were accepted. The strong showing of Asia among submissions (82.7%) and acceptances (81.6%) signals the success of this tenth InCoB anniversary meeting, and bodes well for the future of ISCB-Asia.
Cardiopulmonary Arrest; Defibrillation; History of Medicine; Innovation; Myocardial Infarction