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The title compound, C16H11ClN2O2·H2O, exists in an E conformation with respect to the N=C bond. The benzofuran ring system forms a dihedral angle of 1.26 (4)° with the benzene ring. In the crystal, mol­ecules are linked via (N,C)—H⋯O bifurcated acceptor hydrogen bonds and (O,O,C)—H⋯O trifurcated acceptor hydrogen bonds, forming layers parallel to the bc plane.

In the Schiff base mol­ecule of the title compound, C20H14ClN3O3·CH3COOH·H2O, the central benzene ring makes dihedral angles of 36.26 (7) and 27.59 (8)°, respectively, with the terminal chloro­phenyl and pyridine rings. In the crystal, the three components are linked by O—H⋯O, N—H⋯O, O—H⋯N and C—H⋯O hydrogen bonds into a double-tape structure along the a axis.

The asymmetric unit of the title compound, C14H13ClN2O2S·0.15H2O, a novel sulfonamide derivative, comprises two crystallographically independent mol­ecules (A and B) and a water mol­ecule of crystallization, which is partially occupied. One of the mol­ecules (B) is disordered over two positions (B and C) with refined site occupancies of 0.605 (10) and 0.395 (10). The dihedral angles between the two benzene rings in mol­ecules A, B and C are 67.8 (3), 74.6 (5) and 84.96 (11)°, respectively. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the components of the asymmetric unit. The crystal structure is further stabilized by inter­molecular π–π inter­actions [centroid–centroid distances = 3.4518 (10)–3.5859 (10) Å].

In the title compound, C13H12ClN3·H2O, the organic mol­ecule is almost planar, with a dihedral angle of 3.22 (10)° between the benzene and pyridine rings. The crystal structure is stabilized by O—H⋯N and C—H⋯O hydrogen bonding and π–π stacking inter­actions [centroid–centroid distances = 3.630 (1) and 3.701 (1) Å].

The crystal of the title Schiff base compound, C20H18ClN3O3·H2O, was twinned by a twofold rotation about (100). The asymmetric unit contains two crystallographically independent mol­ecules with similar conformations, and two water mol­ecules. The C=N—N angles of 115.7 (6) and 116.2 (6)° are significantly smaller than the ideal value of 120° expected for sp 2-hybridized N atoms and the dihedral angles between the benzene ring and quinoline ring system in the two mol­ecules are 52.5 (7) and 53.9 (7)°. The mol­ecules aggregate via C—Cl⋯π and π–π inter­actions [centroid–centroid distances = 3.696 (5)–3.892 (5) Å] and weak C—H⋯O inter­actions as parallel sheets, which are further linked by water mol­ecules through N—H⋯O and O—H⋯O hydrogen bonds into a supra­molecular two-dimensional network.

The conformation about each of the imine and ethene bonds in the title hydrazide hydrate, C16H13ClN2O·H2O, is E. The hydrazide mol­ecule is approximately planar (r.m.s. deviation of the 20 non-H atoms = 0.172 Å). The most significant twist occurs about the ethene bond [C—C=C—C = 164.1 (5)°] and the dihedral angle formed between the benzene rings is 5.3 (2)°]. In the crystal, the presence of N—H⋯Ow and O—H⋯Oc (× 2; w = water and c = carbon­yl) hydrogen bonds leads to a supra­molecular array in the bc plane.

In the title compound, C14H12ClN3O2·H2O, the benzene ring and the pyridine rings are oriented at a dihedral angle of 57.73 (12)° and an intra­molecular O—H⋯N hydrogen bond generates an S(6) ring. In the crystal, the water mol­ecule forms O—H⋯O and O—H⋯N hydrogen bonds to the organic mol­ecule, leading to chains containing R 4 4(16) loops. In addition, weak aromatic π–π stacking inter­actions between the centroids of pyridine rings [at distance of 3.864 (2) and 4.013 (2) Å] and C—H⋯π inter­actions occur.

The asymmetric unit of the title compound, C14H11ClN2O, contains two independent mol­ecules. In one mol­ecule, the two aromatic rings form a dihedral angle of 45.94 (16)°, while in the second mol­ecule this angle is 58.48 (16)°. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into two crystallographically independent sets of chains propagating along [001].

In the Schiff base mol­ecule of the title compound, C14H11ClN2O3·2H2O, the benzene rings form a dihedral angle of 20.6 (1)°. The water molecules of crystallization are involved in the formation of a three-dimensional hydrogen-bonding network via O—H⋯O and N—H⋯O hydrogen bonds.

Single crystals of the title compound, C16H14N2O5·H2O, were obtained from a condensation reaction of 1,3-benzodioxole-5-carbohydrazide and 3-methoxy­salicylaldehyde in a 95% ethanol solution. The asymmetric unit consists of a Schiff base mol­ecule, which assumes an E configuration with respect to the C=N bond, and a water mol­ecule of crystallization. The dihedral angle between the two substituted benzene rings is 12.7 (2)°. In the crystal structure, mol­ecules are linked through inter­molecular N—H⋯O and O—H⋯O hydrogen bonds, forming layers parallel to the bc plane.

In the title compound, C13H9ClN4O4, there are two crystallographically independent mol­ecules in the asymmetric unit, which have very similar conformations. The C=N—N angles in each independent mol­ecule are 115.0 (2) and 116.6 (2)°, which are significantly smaller than the ideal value of 120° expected for sp 2-hybridized N atoms. This is probably a consequence of repulsion between the nitro­gen lone pairs and the adjacent N—N bonds. Two bifurcated intra­molecular N—H⋯O hydrogen bonds help to establish the mol­ecular conformation and consolidate the crystal packing.

In the title compound, C12H9ClN2O2·H2O, the dihedral angle between the aromatic rings is 13.9 (2)° and an intra­molecular N—H⋯O hydrogen bond occurs. In the crystal structure, the components are linked by N—H⋯O, O—H⋯O and C—H⋯O hydrogen bonds.

In the title compound, C16H15ClN2O3·H2O, the water mol­ecule is linked to the Schiff base mol­ecule via an O—H⋯O hydrogen bond. In the Schiff base mol­ecule, an intramolecular O—H⋯N hydrogen bond occurs and the dihedral angle between the two benzene rings is 20.5 (5)°. In the crystal, the Schiff base and water mol­ecules are linked by inter­molecular N—H⋯O and O—H⋯O hydrogen bonds, forming layers in the ab plane.

The asymmetric unit of title compound, C20H23ClN2O, consists of two crystallographically independent mol­ecules (A and B) in which the orientations of the 4-isobutyl­phenyl units are different. The isobutyl group of mol­ecule B is disordered over two positions with occupancies of 0.850 (5) and 0.150 (5). The dihedral angle between the two benzene rings is 88.70 (9)° in mol­ecule A and 89.38 (9)° in mol­ecule B. The independent mol­ecules are linked together into chains along [100] by N—H⋯O and C—H⋯O hydrogen bonds, and by C—H⋯π inter­actions. In the chain, N—H⋯O and C—H⋯O hydrogen bonds generate R 2 1(6) ring motifs. In addition, C—H⋯N hydrogen bonds are observed. The presence of pseudosymmetry in the structure suggests the higher symmetry space group Pbca but attempts to refine the structure in this space group resulted in high R (0.119) and wR (0.296) values.

The asymmetric unit of the title compound, C20H16ClN3S, contains two independent mol­ecules, A and B. In mol­ecule A, the dihedral angles between the central benzene ring and the pendant chloro­benzene and phenyl rings are 6.37 (15) and 64.79 (15)°, respectively. The corresponding values in mol­ecule B are 28.21 (14) and 82.11 (16)°, respectively. Each mol­ecule features an intra­molecular N—H⋯N hydrogen bond, which generates an S(5) ring. In the crystal, mol­ecules A and B form dimers, being linked by two N—H⋯S hydrogen bonds with graph-set notation R 2 2(8).

The asymmetric unit of the title compound, C15H13ClN2S2, contains two independent mol­ecules, which are linked into a pseudo-centrosymmetric dimer by inter­molecular N—H⋯S hydrogen bonds. The aromatic rings form dihedral angles of 67.06 (3) and 81.85 (2)° in the two independent mol­ecules.

In the asymmetric unit of the title compound, C19H27ClN4O·0.5C2H6O·1.5H2O, there are two mol­ecules of the Schiff base, which has a rigid adamantyl cage at one end of the C(= O)NH–N=CH– chain and an almost planar [torsion angles = 1.3 (1) and 7.9 (2)° imidazolyl ring at the other end, three mol­ecules of water and one mol­ecule of ethanol. In both independent mol­ecules of the Schiff base, this chain displays an extended zigzag configuration. All their amino groups function as hydrogen-bond donors to water mol­ecules; these are linked to other acceptor atoms, generating a layer structure. O—H⋯O and O—H⋯N inter­actions involving the water mol­ecules also occur.

In the title compound, C14H11ClN2O4·H2O, the dihedral angle between the two benzene rings is 8.5 (2)° and an intra­molecular O—H⋯N hydrogen bond is observed in the Schiff base mol­ecule. In the crystal structure, the water mol­ecule accepts an N—H⋯O hydrogen bond and makes O—H⋯O hydrogen bonds to two further Schiff base mol­ecules. Further inter­molecular O—H⋯O hydrogen bonds lead to the formation of layers parallel to the bc plane.

In the mol­ecule of the title compound, C14H11ClN2O2, the dihedral angle between the benzene rings is 30.53 (4)°. In the crystal structure, inter­molecular O—H⋯O and N—H⋯O hydrogen bonds link the mol­ecules into a two-dimensional network. π–π contacts between benzene rings [centroid–centroid distance = 3.619 (1) Å] may further stabilize the structure. The crystal studied was found to be an inversion twin.

The asymmetric unit of the title compound, C14H11ClN2O2·H2O, contains a Schiff base mol­ecule and a water mol­ecule of crystallization. The dihedral angle between the two aromatic rings is 27.3 (4)°. In the crystal structure, mol­ecules are linked into a two-dimensional network parallel to the bc plane by inter­molecular O—H⋯O and N—H⋯O hydrogen bonds involving the water mol­ecules.

In the title compound, C15H12ClN5O, the mean planes of the benzotriazole and chloro­phenyl fragments form a dihedral angle of 70.8 (1)°. In the crystal, mol­ecules are linked into infinite chains along the a axis by N—H⋯O hydrogen bonds. Weak inter­molecular C—H⋯N hydrogen bonds further link these chains into layers parallel to the ab plane. The crystal studied was a racemic twin.

In the title compound, C22H17Cl2NO2, the asymmetric unit consists of two crystallographically independent mol­ecules and each piperidinone ring adopts an envelope conformation. The dihedral angles between the two chloro­benzene rings are 24.81 (10) and 19.15 (8)° in the two mol­ecules. In the crystal, mol­ecules are connected via weak inter­molecular C—H⋯O hydrogen bonds forming layers perpendicular to the a axis.

The title compound, C14H10ClN3O4·CH4O, was synthesized from the reaction of 5-chloro­salicylaldehyde with 4-nitro­benzohydrazide in methanol. The Schiff base mol­ecule is nearly planar, with a dihedral angle of 9.1 (3)° between the two benzene rings. The methanol solvent mol­ecules are linked to the Schiff base mol­ecules by N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming chains running parallel to the a axis.

The organic mol­ecule of the title monohydrate, C12H9IN2O3·H2O, features a disordered furyl ring with the major component [site occupancy = 0.575 (18)] having the carbonyl O and furyl O atoms syn, and the other conformation having these atoms anti. The mol­ecule is slightly twisted with the dihedral angle between the benzene and furyl rings being 10.3 (6)° (major component). An intra­molecular O—H⋯N(imine) hydrogen bond is formed. In the crystal, the water mol­ecule accepts a hydrogen bond from an amine H atom, and forms two O—H⋯O(carbon­yl) hydrogen bonds, thereby linking three different carbohydrazide mol­ecules. The result is a supra­molecular layer parallel to (001). The closest contacts between layers are of the type I⋯I, at a distance of 3.6986 (6) Å.

The title compound, C12H10N4O2·H2O, was synthesized by the reaction of pyrazine-2-carboxylic acid hydrazide and 3-hydroxy­benzaldehyde in ethanol. In the crystal structure, the organic mol­ecules are linked into extended chains by inter­molecular N(amide)—H⋯O(hydr­oxy) hydrogen bonds. Additional hydrogen bonds between the water mol­ecule and three adjacent organic mol­ecules, as well as face-to-face π–π stacking inter­actions between the benzene and pyrazine rings [centroid-to-centroid separation = 3.669 (2) Å and offset = 1.362 Å], link the mol­ecules into a three-dimensional framework.