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1.  Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin 
Pyridyl derivatives of vanillin increase the fraction of the more soluble oxygenated sickle hemoglobin and/or directly increase the solubility of deoxygenated sickle hemoglobin. Crystallographic analysis reveals the structural basis of the potent and dual antisickling activity of these derivatives.
Vanillin has previously been studied clinically as an antisickling agent to treat sickle-cell disease. In vitro investigations with pyridyl derivatives of vanillin, including INN-312 and INN-298, showed as much as a 90-fold increase in antisickling activity compared with vanillin. The compounds preferentially bind to and modify sickle hemoglobin (Hb S) to increase the affinity of Hb for oxygen. INN-312 also led to a considerable increase in the solubility of deoxygenated Hb S under completely deoxygenated conditions. Crystallographic studies of normal human Hb with INN-312 and INN-298 showed that the compounds form Schiff-base adducts with the N-terminus of the α-subunits to constrain the liganded (or relaxed-state) Hb conformation relative to the unliganded (or tense-state) Hb conformation. Interestingly, while INN-298 binds and directs its meta-positioned pyridine-methoxy moiety (relative to the aldehyde moiety) further down the central water cavity of the protein, that of INN-312, which is ortho to the aldehyde, extends towards the surface of the protein. These studies suggest that these compounds may act to prevent sickling of SS cells by increasing the fraction of the soluble high-affinity Hb S and/or by stereospecific inhibition of deoxygenated Hb S polymerization.
doi:10.1107/S0907444911036353
PMCID: PMC3211971  PMID: 22101818
hemoglobin; oxygen affinity; sickle-cell disease; polymerization; T state; R2 state
2.  2-Benz­yloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one. Corrigendum 
Corrigendum to Acta Cryst. (2011), E67, o1861.
The name of one of the authors in the paper by Al-Salahi et al. [Acta Cryst. (2011), E67, o1861] is corrected.
doi:10.1107/S1600536811037780
PMCID: PMC3201416  PMID: 22065309
3.  N-tert-Butyl-2-methyl­propanamide. Corrigendum 
Corrigendum to Acta Cryst. (2011), E67, o2143.
The name of one of the authors in the paper by Kluge et al. [Acta Cryst. (2011), E67, o2143] is corrected.
doi:10.1107/S1600536811048902
PMCID: PMC3238574  PMID: 22199465
4.  Tetra­kis-μ-l-alanine-κ8 O:O′-bis­[tetra­aqua­terbium(III)] hexa­perchlorate. Corrigendum 
Corrigendum to Acta Cryst. (2009), E66, m193–m194.
The surname of one of the authors and the affiliation of that author in the paper by Mohamed et al. [Acta Cryst. (2009), E66, m193–m194] are corrected.
doi:10.1107/S1600536810027340
PMCID: PMC3007475  PMID: 21588076
5.  Poly[bis­(μ-hemihydrogen 2-phenyl­quinoline-4-carboxyl­ato-κ2 N,O)silver(I)]. Corrigendum 
Corrigendum to Acta Cryst. (2009), E65, m223.
The affiliation of one of the authors in the paper by Zhang, Wei & Li [Acta Cryst. (2009), E65, m223] is corrected.
doi:10.1107/S160053680900628X
PMCID: PMC2968588  PMID: 21582030
6.  Corrigenda 
Corrigenda for five articles.
The affiliation of one of the authors and a source of funding are both added in the following papers: Chiririwa & Meijboom [Acta Cryst. (2011a), E67, m1496; Acta Cryst. (2011b), E67, m1497; Acta Cryst. (2011c), E67, m1498] and Chiririwa & Muller [Acta Cryst. (2012a), E68, m49; Acta Cryst. (2012b), E68, m116–m117].
doi:10.1107/S160053681201817X
PMCID: PMC3344282
7.  Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. Corrigendum 
A corrigendum to the article by Inoguchi et al. [(2013). Acta Cryst. F69, 393–398].
The affiliation of two authors in the article by Inoguchi et al. [(2013). Acta Cryst. F69, 393–398] is corrected.
doi:10.1107/S1744309113011093
PMCID: PMC3668601
hemoglobin; deer mouse; oxygen affinity; Peromyscus maniculatus; corrigendum
8.  Poly[[tetra-μ2-aqua-diaqua-μ6-oxalato-barium(II)] 2,4,6-trinitro­phenolate monohydrate]. Corrigendum 
Corrigendum to Acta Cryst. (2007), E63, o2296.
In the paper by Hong, Song & Wu [Acta Cryst. (2007), E63, o2296], the scheme shows the wrong structure. The correct scheme is shown below and the compound name is corrected to "poly[[di-μ2-aqua-diaqua-hemi-μ6-oxalato-barium(II)] 2,4,6-trinitro­phenolate monohydrate", {[Ba(C2O4)0.5(H2O)4]C6H2N3O7·H2O}n.
doi:10.1107/S1600536807067542
PMCID: PMC2914902  PMID: 21200449
9.  Preliminary crystallographic data of the three homologues of the thiol–disulfide oxidoreductase DsbA in Neisseria meningitidis. Corrigendum 
A corrigendum to the paper by Lafaye et al. [Acta Cryst. (2008). F64, 111–114].
A correction is made to the name one of the authors of Lafaye et al. [Acta Cryst. (2008). F64, 111–114].
doi:10.1107/S1744309108020307
PMCID: PMC2494962
neisseria; virulence; oxidoreductases; corrigendum
10.  Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses. Corrigendum 
A corrigendum to the paper by Mastrangelo et al. (2006), Acta Cryst. F62, 768–770.
A correction is made to the names of two of the authors in Mastrangelo et al. (2006), Acta Cryst. F62, 768–770.
doi:10.1107/S1744309107009098
PMCID: PMC2330174
(nucleoside-2′-O-)-methyltransferases; flaviviruses; Meaban virus; Yokose virus; corrigendum
11.  2-[4-(Diethyl­amino)phen­yl]-1-ethyl­imidazo[4,5-f][1,10]­phenanthroline. Corrigendum 
Corrigendum to Acta Cryst. (2007), E63, o1210–o1211.
The list of authors in the paper by Sun, Chen, Ling & Liu [Acta Cryst. (2007), E63, o1210–o1211] is corrected.
doi:10.1107/S1600536808021582
PMCID: PMC2960653  PMID: 21201562
12.  (Z)-1,2-Bis(4-nitro­phen­yl)ethene. Corrigendum 
Corrigendum to Acta Cryst. (2007), E63, o3999.
The name of the first author in the paper by Chen & Cao [Acta Cryst. (2007), E63, o3999] is corrected.
doi:10.1107/S1600536808009999
PMCID: PMC2961310  PMID: 21202160
13.  2-Hydr­oxy-N′-(4-isopropyl­cyclo­hexyl­carbon­yl)-3-methyl­benzohydrazide. Corrigendum 
Corrigendum to Acta Cryst. (2009), E65, o575.
The author list in the paper by Shu, Wen, Chen & Lei [Acta Cryst. (2009), E65, o575] is corrected.
doi:10.1107/S1600536809017863
PMCID: PMC2969520  PMID: 21582974
14.  (Benzonitrile-κN)chlorido[hydrido­tris(pyrazol-1-yl-κN 2)borato](triphenyl­phosphine-κP)ruthenium(II) ethanol solvate. Corrigendum 
Corrigendum to Acta Cryst. (2009), E65, m438.
The author list in the paper by Tong, Hung, Wang, Lin & Lo [Acta Cryst. (2009), E65, m438] is corrected.
doi:10.1107/S1600536809016183
PMCID: PMC2969808  PMID: 21582972
15.  3,3′-(2,2′-Bi-1H-imidazole-1,1′-di­yl)dipropanamide. Corrigendum 
Corrigendum to Acta Cryst. (2009), E65, o2008.
The list of authors in the paper by Zhi, Long, Chen & Ren [Acta Cryst. (2009), E65, o2008] is corrected and the acknowledgements are updated.
doi:10.1107/S1600536810017526
PMCID: PMC2979391  PMID: 21579263
16.  N′-[(E)-(1-Methyl-1H-pyrrol-2-yl)methyl­idene]pyridine-4-carbohydrazide. Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, o1881.
The name of one of the authors in the paper by Hussain et al. [Acta Cryst. (2010), E66, o1881] is corrected.
doi:10.1107/S1600536810031090
PMCID: PMC3008127  PMID: 21588469
17.  2-C-Hydro­xymethyl-2,3-O-iso­propyl­idene-d-ribono-1,5-lactam. Corrigendum 
Corrigendum to Acta Cryst. (2004), E60, o909–o910.
The name of one of the authors in the paper by Newton et al. [Acta Cryst. (2004), E60, o909–o910] is corrected.
doi:10.1107/S1600536810043096
PMCID: PMC3011533  PMID: 21589197
18.  3-(2,5-Dimethyl­furan-3-yl)-1H-pyrazol-5-ol–ethyl 3-(propan-2-yl­idene)carbazate (1/1). Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, o3020–o3021.
The address of three of the authors in the paper by Shahani et al. [Acta Cryst. (2010), E66, o3020–o3021] is corrected.
doi:10.1107/S1600536810047859
PMCID: PMC3011539  PMID: 21589200
19.  Melaminium nitrate–melamine–water (1/1/1). Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, o3033–o3034.
The name of one of the authors in the paper by Adam et al. [Acta Cryst. (2010), E66, o3033–o3034] is corrected.
doi:10.1107/S1600536810047847
PMCID: PMC3011635  PMID: 21589199
20.  Piperazine-2,3,5,6-tetra­one. Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, o3315.
The correspondence author in the paper by Jia et al. [Acta Cryst. (2010), E66, o3315] is corrected.
doi:10.1107/S1600536810052712
PMCID: PMC3050199
21.  3-(tert-But­oxy­carbon­yl)-2-(4-chloro­phen­yl)-1,3-thia­zolidine-4-carb­oxy­lic acid. Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, o2633.
The author list in the paper by Ding [Acta Cryst. (2010), E66, o2633] is corrected.
doi:10.1107/S1600536810048774
PMCID: PMC3050324
22.  Dichlorido{4-cyclo­hexyl-1-[1-(2-pyridyl-κN)ethyl­idene]thio­semicarbazidato-κ2 N 1,S}methyl­tin(IV). Corrigendum 
Corrigendum to Acta Cryst. (2010), E66, m570.
The address of one of the authors in the paper by Salam et al. [Acta Cryst. (2010), E66, m570] is corrected.
doi:10.1107/S1600536810049214
PMCID: PMC3050345
23.  2-Acet­amido-4,5-di­nitro­toluene: a test mol­ecule for the CCDC ‘Blind Structure Prediction Test, 2004’. Corrigendum 
Corrigendum to Acta Cryst. (2004), E60, o2295–o2297.
The name of one of the authors in the paper by Watkin et al. [Acta Cryst. (2004), E60, o2295–o2297] is corrected.
doi:10.1107/S1600536812039670
PMCID: PMC3470118
24.  Potassium morpholine-4-carbodithio­ate monohydrate. Corrigendum 
Corrigendum to Acta Cryst. (2012), E68, m1025.
The author list in the paper by Mafud [Acta Cryst. (2012), E68, m1025] is corrected.
doi:10.1107/S1600536813008994
PMCID: PMC3647780
25.  4-[(6-Chloro-2-pyrid­yl)meth­oxy]-3-(2,4-dichloro­phen­yl)-1-oxaspiro­[4.5]dec-3-en-2-one. Corrigendum 
Corrigendum to Acta Cryst. (2009), E65, o846.
The chemical name of the title compound in the paper by Xu, Huang & Guo [Acta Cryst. (2009), E65, o846] is corrected and the structural diagram is updated.
doi:10.1107/S1600536809023290
PMCID: PMC2969292  PMID: 21582640

Results 1-25 (861293)