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1.  Plasma glial fibrillary acidic protein levels in children with sickle cell disease 
American journal of hematology  2011;86(5):10.1002/ajh.21995.
To determine if glial fibrillary acidic protein (GFAP) is associated with brain injury in children with sickle cell disease (SCD), we measured plasma GFAP among cross-sectional groups of unselected children with SCD, subsets of children with SCD and normal brain MRI or MRI evidence of cerebral infarct, healthy pediatric controls, and adults with brain injury. Children with SCD had higher plasma GFAP than healthy pediatric controls (mean concentrations 0.14±0.37 vs. 0.07±0.08 ng/mL; P=0.003); also, 16.0% (16/100) of children with SCD and cerebral infarct had GFAP elevations above the 95th percentile of healthy pediatric controls (P=0.04). Although not statistically significant, more children with SCD and cerebral infarct had elevated GFAP levels than children with SCD and no infarct (16/100, 16.0% vs. 14/168, 8.3%; P=0.07). Children with SCD and acute brain ischemia had a higher proportion of elevated GFAP than SCD children with normal MRI (3/6, 50% vs. 8.3%; P=0.01). GFAP was associated with elevated systolic blood pressure in the preceding year and correlated positively with white blood cell count and negatively with age and performance IQ. Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury.
doi:10.1002/ajh.21995
PMCID: PMC3870012  PMID: 21523806
sickle cell; cerebral infarct; glial fibrillary acidic protein
2.  Proteomic and Biomarker Studies and Neurological Complications of Pediatric Sickle Cell Disease 
Biomarker analysis and proteomic discovery in pediatric sickle cell disease has the potential to lead to important discoveries and improve care. The aim of this review article is to describe proteomic and biomarker articles involving neurological and developmental complications in this population. A systematic review was conducted to identify relevant research publications. Articles were selected for children under the age of 21 years with the most common subtypes of sickle cell disease. Included articles were focused on growth factors (platelet-derived growth factor), intra and extracellular brain proteins (glial fibrillary acidic protein, brain-derived neurotrophic factor), and inflammatory and coagulation markers (interleukin-1β, L-selectin, thrombospondin-1, erythrocyte and platelet-derived microparticles). Positive findings include increases in plasma brain-derived neurotrophic factor and platelet-derived growth factor with elevated transcranial Dopplers velocities, increases in platelet-derived growth factor isoform AA with overt stroke, and increases in glial fibrillary acidic protein with acute brain injury. These promising potential neuro-biomarkers provide insight into pathophysiologic processes and clinical events, but their clinical utility is yet to be established. Additional proteomics research is needed, including broad-based proteomic discovery of plasma constituents and blood cell proteins, as well as urine and cerebrospinal fluid components, before, during and after neurological and developmental complications.
doi:10.1002/prca.201400069
PMCID: PMC4268655  PMID: 25290359
biological markers; neurodevelopment; proteomics; sickle cell; stroke
3.  The prevalence of hypertension and abnormal kidney function in children with sickle cell disease –a cross sectional review 
BMC Nephrology  2013;14:237.
Background
Renal disease is a known contributor to mortality in adults with sickle cell disease (SCD) and renal abnormalities are evident in childhood. Hyperfiltration (evidenced by elevated glomerular filtration rate, GFR) occurs in children with SCD early in disease. However, the incidence of low GFR (<90 ml/min/1.73 m2) suggestive of chronic kidney disease (CKD), is not well established. The prevalence of hypertension is also not well known. The goal of this study was to determine the prevalence of hypertension and CKD in a cohort of children with SCD.
Methods
We performed a retrospective chart review of patients followed at the Rainbow Babies and Children’s Sickle Cell Disease Clinic who were seen during routine follow up visits. Inclusion criteria were all patients ages 3–18. Exclusion criteria included recent (within 2 weeks) hospitalization and/or episode of acute chest, pain crises, febrile illness or red blood cell transfusion. Data collected included serum creatinine, blood pressure and history of sickle cell complications (acute chest syndrome, stroke or stroke risk). Estimated GFR (eGFR) was calculated using the updated Schwartz creatinine-based estimating formula. Analysis examined the associations among eGFR, blood pressure and sickle cell complications. The Institutional Review Board at University Hospitals Case Medical Center approved this study.
Results
A total of 48 children had complete data available. Mean eGFR was 140 mL/min/1.73 m2 +/- 34.9 (range 71.9-404.2 mL/min/1.73 m2). Four patients (8.3%) had eGFRs < 90 mL/min/1.73 m2, 35 patients (72.9%) had eGFRs > 120 mL/min/1.73 m2 and 9 patients (18.8%) had eGFRs in the normal range. Eight patients (16.7%) had evidence of elevated blood pressures (pre-hypertension or hypertension). There was no correlation between eGFR and age, and no association of eGFR with acute chest or stroke risk.
Conclusion
In this SCD cohort, we identified abnormally low eGFR (suggestive of early CKD) in 8.3% of patients and elevated blood pressure in 16.7%. These findings are in contrast to other published studies that show primarily normal or elevated GFR and the absence of or minimal hypertension. These findings indicate that elevated blood pressure and decreased eGFR are not uncommon in children with SCD, and should be more rigorously studied.
doi:10.1186/1471-2369-14-237
PMCID: PMC4231610  PMID: 24168027
Sickle cell disease; Nephropathy; Chronic kidney disease; Hypertension
4.  Preoperative blood transfusions for sickle cell disease 
Background
Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Surgical interventions are more common in people with sickle cell disease, and occur at much younger ages than in the general population. Blood transfusions are frequently used prior to surgery and several regimens are used but there is no consensus over the best method or the necessity of transfusion in specific surgical cases. This is an update of a Cochrane review first published in 2001.
Objectives
To determine whether there is evidence that preoperative blood transfusion in people with sickle cell disease undergoing elective or emergency surgery reduces mortality and perioperative or sickle cell-related serious adverse events.
To compare the effectiveness of different transfusion regimens (aggressive or conservative) if preoperative transfusions are indicated in people with sickle cell disease.
Search methods
We searched for relevant trials in The Cochrane Library, MEDLINE (from 1946), Embase (from 1974), the Transfusion Evidence Library (from 1980), and ongoing trial databases; all searches current to 23 March 2016.
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register: 18 January 2016.
Selection criteria
All randomised controlled trials and quasi-randomised controlled trials comparing preoperative blood transfusion regimens to different regimens or no transfusion in people with sickle cell disease undergoing elective or emergency surgery. There was no restriction by outcomes examined, language or publication status.
Data collection and analysis
Two authors independently assessed trial eligibility and the risk of bias and extracted data.
Main results
Three trials with 990 participants were eligible for inclusion in the review. There were no ongoing trials identified. These trials were conducted between 1988 and 2011. The majority of people included had haemoglobin (Hb) SS SCD. The majority of surgical procedures were considered low or intermediate risk for developing sickle cell-related complications.
Aggressive versus simple red blood cell transfusions
One trial (551 participants) compared an aggressive transfusion regimen (decreasing sickle haemoglobin to less than 30%) to a simple transfusion regimen (increasing haemoglobin to 100 g/l). This trial re-randomised participants and therefore quantitative analysis was only possible on two subsets of data: participants undergoing cholecystectomy (230 participants); and participants undergoing tonsillectomy or adenoidectomy surgeries (107 participants). Data were not combined as we do not know if any participant received both surgeries. Overall, the quality of the evidence was very low across different outcomes according to GRADE methodology. This was due to the trial being at high risk of bias primarily due to lack of blinding, indirectness and the outcome estimates being imprecise. Cholecystectomy subgroup results are reported in the abstract. Results for both subgroups were similar.
There was no difference in all-cause mortality between people receiving aggressive transfusions and those receiving conservative transfusions. No deaths occurred in either subgroup.
There were no differences between the aggressive transfusion group and conservative transfusion group in the number of people developing: an acute chest syndrome, risk ratio 0.84 (95% confidence interval 0.38 to 1.84) (one trial, 230 participants, very low quality evidence);vaso-occlusive crisis, risk ratio 0.30 (95% confidence interval 0.09 to 1.04) (one trial, 230 participants, very low quality evidence);serious infection, risk ratio 1.75 (95% confidence interval 0.59 to 5.18) (one trial, 230 participants, very low quality evidence);any perioperative complications, risk ratio 0.75 (95% confidence interval 0.36 to 1.55) (one trial, 230 participants, very low quality evidence);a transfusion-related complication, risk ratio 1.85 (95% confidence interval 0.89 to 3.88) (one trial, 230 participants, very low quality evidence).
Preoperative transfusion versus no preoperative transfusion
Two trials (434 participants) compared a preoperative transfusion plus standard care to a group receiving standard care. Overall, the quality of the evidence was low to very low across different outcomes according to GRADE methodology. This was due to the trials being at high risk of bias due to lack of blinding, and outcome estimates being imprecise. One trial was stopped early because more people in the no transfusion arm developed an acute chest syndrome.
There was no difference in all-cause mortality between people receiving preoperative transfusions and those receiving no preoperative transfusions (two trials, 434 participants, no deaths occurred).
There was significant heterogeneity between the two trials in the number of people developing an acute chest syndrome, a meta-analysis was therefore not performed. One trial showed a reduced number of people developing acute chest syndrome between people receiving preoperative transfusions and those receiving no preoperative transfusions, risk ratio 0.11 (95% confidence interval 0.01 to 0.80) (65 participants), whereas the other trial did not, risk ratio 4.81 (95% confidence interval 0.23 to 99.61) (369 participants).
There were no differences between the preoperative transfusion groups and the groups without preoperative transfusion in the number of people developing: a vaso-occlusive crisis, Peto odds ratio 1.91 (95% confidence interval 0.61 to 6.04) (two trials, 434 participants, very low quality evidence).a serious infection, Peto odds ratio 1.29 (95% confidence interval 0.29 to 5.71) (two trials, 434 participants, very low quality evidence);any perioperative complications, risk ratio 0.24 (95% confidence interval 0.03 to 2.05) (one trial, 65 participants, low quality evidence).
There was an increase in the number of people developing circulatory overload in those receiving preoperative transfusions compared to those not receiving preoperative transfusions in one of the two trials, and no events were seen in the other trial (no meta-analysis performed).
Authors’ conclusions
There is insufficient evidence from randomised trials to determine whether conservative preoperative blood transfusion is as effective as aggressive preoperative blood transfusion in preventing sickle-related or surgery-related complications in people with HbSS disease. There is very low quality evidence that preoperative blood transfusion may prevent development of acute chest syndrome.
Due to lack of evidence this review cannot comment on management for people with HbSC or HbSβ+ disease or for those with high baseline haemoglobin concentrations.
doi:10.1002/14651858.CD003149.pub3
PMCID: PMC4854326  PMID: 27049331
*Hemoglobin, Sickle; Anemia, Sickle Cell [blood; *surgery]; Blood Transfusion [adverse effects; *methods]; Preoperative Care [*methods]; Randomized Controlled Trials as Topic; Humans
5.  Can STOP Trial Velocity Criteria Be Applied to Iranian Children with Sickle Cell Disease? 
Journal of Stroke  2014;16(2):97-101.
Background and Purpose
Sickle cell disease (SCD) is strongly linked to stroke across all haplotypes in the pediatric population. Transcranial Doppler (TCD) ultrasound is known to identify the highest risk group in African-Americans who need to receive and stay on blood transfusions, but it is unclear if the same flow velocity cut-offs can be applied to the Iranian population. We aimed to evaluate baseline TCD findings in Iranian children with SCD and no prior strokes.
Methods
Children with genetically confirmed SCD (Arabian haplotype, homozygote) and without SCD (controls) were prospectively recruited from pediatric outpatient clinic over a period of 9 months. We performed TCD in both groups to determine flow velocities in the middle cerebral (MCA) and terminal internal carotid arteries (TICA).
Results
Of 74 screened children, 60 met the inclusion/exclusion criteria (62% female; mean age 10±4 years). Baseline characteristics did not differ between the cases and controls, except hemoglobin (Hb) which was significantly lower in the SCD group (P<0.001). The right MCA TAMM (Time Averaged Maximum Mean) was significantly higher than in controls (125+5.52 cm/s vs. 92.5+1.63 cm/s, P<0.001). Left MCA did not show differences. The TICA TAMM was also different between cases and controls (P<0.05).
Conclusions
Among Iranian children with asymptomatic SCD and without receiving recent transfusion TCD velocities are higher as compared to healthy controls but appear much lower than those observed in STOP (Stroke Prevention Trial in Sickle Cell Anemia) studies. We hypothesize that some children at high risk may be present with velocities lower than 170-200 cm/s thresholds. A prospective validation of ethnicity-specific prognostic criteria is warranted.
doi:10.5853/jos.2014.16.2.97
PMCID: PMC4060272  PMID: 24949316
Sickle cell; TCD; STOP criteria
6.  Sickle cell disease 
BMJ Clinical Evidence  2011;2011:2402.
Introduction
Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease.
Methods and outcomes
We conducted a systematic review and aimed to answer the following clinical questions: what are the effects of pharmaceutical and non-pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? What are the effects of pharmaceutical and non-pharmaceutical interventions to treat pain in people with sickle cell crisis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results
We found 38 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions
In this systematic review we present information relating to the effectiveness and safety of the following interventions: acupuncture, antibiotic prophylaxis in children <5 years of age, antibiotic prophylaxis in children >5 years of age, aspirin, avoidance of cold environment, blood transfusion, codeine, corticosteroid (with narcotic analgesics), diflunisal, hydration, hydroxyurea, ibuprofen, ketorolac, limiting physical exercise, malaria chemoprophylaxis, morphine (controlled-release oral after initial intravenous bolus, repeated intravenous doses), oxygen, paracetamol, patient-controlled analgesia, pneumococcal vaccines, and rehydration.
Key Points
In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease. Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion.
We don’t know whether avoidance of cold environments, physical exercise, or rehydration can prevent crises or complications in people with sickle cell disease. Blood transfusion (prophylactic) reduces stroke in children at increased risk of stroke, but increases the risks of iron overload, allo-immunisation, hypertensive or circulatory overload, febrile non-haemolytic reactions, allergic reactions, and haemolytic events. Penicillin prophylaxis in children <5 years of age reduces invasive pneumococcal infections regardless of pneumococcal vaccination status. We don’t know whether penicillin prophylaxis is beneficial in older children. Malaria chemoprophylaxis is considered useful in preventing malaria-induced crises, but we found few studies evaluating its benefit.Polyvalent polysaccharide pneumococcal vaccine does not reduce the incidence of pneumococcal infections in people with sickle cell disease. Pneumococcal conjugate vaccines have been reported to have protective efficacy in children <2 years of age, but this protective effect has not been shown in infants with sickle cell disease.
Hydroxyurea may reduce some complications of sickle cell disease, such as painful crises compared with placebo, but long-term effects and safety are unknown.
Morphine is widely used to treat severe pain, but we found no RCT evidence comparing it with placebo in people with sickle cell crises. Controlled-release oral morphine and patient-controlled analgesia may be as effective as repeated intravenous doses of morphine. Oral morphine increases the risk of acute chest syndrome compared with intravenous administration. High-dose corticosteroids may reduce the need for analgesia when added to intravenous morphine in people with a sickle cell crisis, but may increase the risks of adverse effects (such as infections, hypertension, and metabolic problems).
It is still unclear whether acupuncture, blood transfusion, hydration, oxygen, aspirin, codeine, diflunisal, ibuprofen, ketorolac, or paracetamol reduce pain during sickle cell crisis.
PMCID: PMC3217656  PMID: 21718552
7.  French Intensive Care Society, International congress – Réanimation 2016 
Jaillette, Emmanuelle | Girault, Christophe | Brunin, Guillaume | Zerimech, Farid | Chiche, Arnaud | Broucqsault-Dedrie, Céline | Fayolle, Cyril | Minacori, Franck | Alves, Isabelle | Barrailler, Stephanie | Robriquet, Laurent | Delaporte, Emmanuel | Thellier, Damien | Delcourte, Claire | Duhamel, Alain | Nseir, Saad | Valette, Xavier | Desmeulles, Isabelle | Savary, Benoit | Masson, Romain | Seguin, Amélie | Daubin, Cédric | Sauneuf, Bertrand | Verrier, Pierre | Pottier, Véronique | Orabona, Marie | Samba, Désiré | Viquesnel, Gérald | Lermuzeaux, Mathilde | Hazera, Pascal | Hanouz, Jean-Luc | Parienti, Jean-Jacques | Du Cheyron, Damien | Demoule, Alexandre | Clavel, Marc | Rolland-Debord, Camille | Perbet, Sébastien | Terzi, Nicolas | Kouatchet, Achille | Wallet, Florent | Roze, Hadrien | Vargas, Frédéric | Guérin, Claude | Dellamonica, Jean | Jaber, Samir | Similowski, Thomas | Quenot, Jean-Pierre | Binquet, Christine | Vinsonneau, Christophe | Barbar, Saber-Davide | Vinault, Sandrine | Deckert, Valérie | Lemaire, Stephanie | Hssain, Ali Ait | Bruyère, Rémi | Souweine, Bertrand | Lagrost, Laurent | Adrie, Christophe | Jung, Boris | Daurat, Aurelien | De Jong, Audrey | Chanques, Gérald | Mahul, Martin | Monnin, Marion | Molinari, Nicolas | Lheureux, Olivier | Trepo, Eric | Hites, Maya | Cotton, Frederic | Wolff, Fleur | Surin, Rudy | Créteur, Jacques | Vincent, Jean-Louis | Gustot, Thierry | Jacobs, Frederique | Taccone, Fabio Silvio | Neuville, Mathilde | Timsit, Jean-François | El-Helali, Najoua | Le Monnier, Alban | Magalhaes, Eric | Radjou, Aguila | Smonig, Roland | Soubirou, Jean-François | Voiriot, Guillaume | Sonneville, Romain | Bouadma, Lila | Mourvillier, Bruno | Gélisse, Elodie | Brasseur, Alexandre | Roisin, Sandrine | De Backer, Daniel | Van Ruychevelt, Valerie | Carlier, Eric | Piagnerelli, Michael | Vanhaeverbeek, Michel | Danguy, Christine | Biston, Patrick | Au, Siu-Ming | Begot, Emmanuelle | Dalmay, François | Repessé, Xavier | Prat, Gwenael | Bouferrache, Koceila | Slama, Michel | Vieillard-Baron, Antoine | Monnet, Xavier | Marik, Paul | Teboul, Jean-Louis | Jozwiak, Mathieu | Richard, Christian | Chauvet, Jean-Louis | El-Dash, Shari | Delastre, Olivier | Bouffandeau, Bernard | Jusserand, Dominique | Michot, Jean-Baptiste | Bauer, Fabrice | Brazier, François | Mercado, Pablo | Kontar, Loay | Titeca, Dimitri | De Cagny, Bertand | Bacari-Risal, Gaelle | Riviere, Antoine | Maizel, Julien | Guillot, Camille | Le Reun, Claire | Lampin, Marie | Sadik, Ahmed | Botte, Astrid | Leteurtre, Stéphane | Collins, Aurélie | Kempeneers, Céline | Cajgfinger, Nathalie | Ohlmann, Camille | Pouyau, Robin | Subtil, Fabien | Baudin, Florent | Massenavette, Bruno | Javouhey, Etienne | Milesi, Christophe | Essouri, Sandrine | Liet, Jean-Michel | Afanetti, Mickael | Durand, Sabine | Durand, Philippe | Roze, Jean Christophe | Dupont, Didier | Cambonie, Gilles | Soyer, Benjamin | Rusca, Marco | Lukaszewicz, Anne-Claire | Crassard, Isabelle | Guichard, Jean-Pierre | Bresson, Damien | de la Garanderie, Didier Payen | Cantier, Marie | Sabben, Candice | Louedec, Liliane | Delbosc, Sandrine | Journé, Clément | Ou, Phalla | Klein, Isabelle | Chau, Françoise | Lefort, Agnes | Desilles, Jean-Philippe | Michel, Jean-Baptiste | Mazighi, Mikaël | Salem, Omar Ben Hadj | Demeret, Sophie | Bolgert, Francis | Sharshar, Tarek | Grabli, David | Arib, Safa | Crippa, Ilaria Alice | Soummer, Alexis | Engrand, Nicolas | Guedin, Pierre | Aldea, Sorin | Cerf, Charles | Desailly, Victoire | Pasquier, Pierre | Brun, Patrick | Roux, Damien | Latournerie, Gwendoline | Kasprzyk, Laetitia | Grosjean, Vincent | Latreche, Amine | Habert, Pierre | Huot, Stephane | Jobin, Timon | Tesnière, Antoine | Dreyfuss, Didier | Ricard, Jean-Damien | Mignon, Alexandre | Gaudry, Stéphane | Laithier, François-Xavier | Kimmoun, Antoine | Chouihed, Tahar | Albizzati, Stéphane | Camenzind, Edoardo | Vanhuyse, Fabrice | Levy, Bruno | Cour, Martin | Venet, Fabienne | Hernu, Romain | Demaret, Julie | Monneret, Guillaume | Argaud, Laurent | Dumas, Florence | Lamhaut, Lionel | Rosencher, Julien | Pène, Frédéric | Varenne, Olivier | Carli, Pierre | Jouven, Xavier | Spaulding, Christian | Cariou, Alain | Geri, Guillaume | Bonnetain, Franck | Marijon, Eloi | Empana, Jean Philippe | Mirouse, Adrien | Resche-Rigon, Matthieu | Mayaux, Julien | Rabbat, Antoine | Meert, Anne Pascale | Benoit, Dominique | Bruneel, Fabrice | Azoulay, Elie | Dupuis, Claire | Schwebel, Carole | Ruckly, Stéphane | Goldgran-Toledano, Dany | Marcotte, Guillaume | Lafarge, Antoine | Pichereau, Claire | Theodose, Igor | Scotto, Marion | Kemlin, Delphine | Ghrenassia, Etienne | Schlemmer, Benoît | Vimpere, Damien | Galicier, Lionel | Contou, Damien | Guérot, Emmanuel | Grimaldi, David | Ricome, Sylvie | Maury, Eric | Plantefève, Gaëtan | Dessap, Armand Mekontso | Brun-Buisson, Christian | de Prost, Nicolas | Dubé, Bruno-Pierre | Delemazure, Julie | Dres, Martin | Rousseau, Ludivine | Drouot, Xavier | Diaz, Véronique | Rebollar, Yohann | Frat, Jean-Pierre | Thille, Arnaud W. | Aissa, Dalinda Ait | Coquet, Pierre | Ruiz, Jean | Ferre, Fabrice | Hoarau, Lucille | Riu-Poulenc, Béatrice | Bataille, Benoit | Silva, Stein | Baudel, Jean-Luc | Bigé, Naïke | Tahiri, Jalel | Dubée, Vincent | Guidet, Bertrand | Ait-Oufella, Hafid | Jinglun, Liu | Shen, Feng | Monnet, Xavier | Bailly, Sébastien | Leroy, Olivier | Montravers, Philippe | Constantin, Jean-Michel | Dupont, Hervé | Guillemot, Didier | Lortholary, Olivier | Perrigault, Pierre-François | Gangneux, Jean-Pierre | Razazi, Keyvan | Mekontso-Dessap, Armand | Jansen, Chloe | Lecronier, Marie | Sandrine, Valade | Mira, Jean-Paul | Blein, Sophie | Marin, Nathalie | Rousseau, Christophe | Charpentier, Julien | Pachot, Alexandre | Hraiech, Sami | Bordes, Julien | De, Lamballerie Xavier | Mège, Jean-Louis | Forel, Jean-Marie | Guervilly, Christophe | Adda, Mélanie | Raoult, Didier | Papazian, Laurent | Kentish-Barnes, Nancy | Cohen-Solal, Zoé | Kentish-Barnes, Nancy | Souppart, Virginie | Kerhuel, Lionel | Haubertin, Carole | Exbrayat, Isabelle | Rozières, Elodie | Argain, Audrey | Suc, Agnès | Vignes, Michel | Cougot, Pierre | Fourcade, Olivier | Brunel, Elodie | Messika, Jonathan | Tubach, Florence | Dubief, Emeline | Pasquet, Blandine | Guillo, Sylvie | Pierron, Charlotte | Grimaud, Marion | Farnoux, Caroline | Maillard, Amélie | Decavèle, Maxens | Prodanovic, Hélène | Idbaih, Ahmed | Alentorn, Agusti | Delattre, Jean-Yves | De Montmollin, Etienne | Brule, Noelle | Conrad, Marie | Dailler, Frédéric | Navellou, Jean-Christophe | Alves, Mikael | Tonnelier, Jean-Marie | Ruckly, Stephane | Picard, Géraldine | Rogemond, Véronique | Honnorat, Jérôme | Marzorati, Chiara | Lebert, Christine | Perez, Pierre | Citerio, Giuseppe | Legriel, Stéphane | Tripon, Simona | Mallet, Maxime | Rudler, Marika | Imbert-Bismut, Francoise | Thabut, Dominique | Canet, Emmanuel | Faguer, Stanislas | Moreau, Anne-Sophie | Barbier, François | Merceron, Sybille | Guitton, Christophe | Labadie, Francois | Lemiale, Virginie | Faucher, Etienne | Klouche, Kada | Chevret, Sylvie | Ragot, Stéphanie | Coudroy, Remi | Boulain, Thierry | Jamet, Angéline | Mercat, Alain | Brochard, Laurent | Roux, Antoine | Lemiale, Virginie | Franchineau, Guillaume | Brechot, Nicolas | Lebreton, Guillaume | Hekimian, Guillaume | Nieszkowska, Ania | Leprince, Pascal | Trouillet, Jean Louis | Combes, Alain | Schmidt, Matthieu | Barrot, Loïc | Piton, Gaël | Bailey, Michael | Panwar, Rakshit | Belin, Nicolas | Belon, François | Patry, Cyrille | Grandperrin, Mathilde | Chaignat, Claire | Labro, Guylaine | Vivet, Bérengère | Capellier, Gilles | Daix, Thomas | Guérin, Estelle | Tavernier, Elsa | Mercier, Emmanuelle | Gissot, Valérie | Vallejo, Christine | François, Bruno | Ravry, Céline | Pichon, Nicolas | Chapellas, Catherine | Fedou, Anne-Laure | Galy, Antoine | Ploy, Marie-Cécile | Barraud, Olivier | Vignon, Philippe | Thooft, Aurelie | Conotte, Raphael | Colet, Jean-Marie | Le Dorze, Matthieu | Tarazona, Virginie | Brumpt, Caren | Moins-Teisserenc, Hélène | Uhel, Fabrice | Azzaoui, Imane | Gregoire, Murielle | Pangault, Céline | Dulong, Joëlle | Cynober, Luc | Roussel, Mikaël | Le Tulzo, Yves | Tarte, Karin | Demiselle, Julien | Auchabie, Johann | Dequin, Pierre François | Chudeau, Nicolas | Fourrier, François | Grange, Steven | Piquilloud, Lise | Lautrette, Alexandre | Boyer, Sonia | Letheulle, Julien | Lerolle, Nicolas | Truche, Anne Sophie | Clec’h, Christophe | Zaoui, Philippe | Laurent, Virginie | Toledano, Dany Goldgran | Ragey, Sophie Perinel | Gros, Antoine | Dumenil, Anne Sylvie | Jamali, Samir | Darmon, Michaël | Chouraqui, Mikhael | Dewitte, Antoine | Chastel, Brigitte | Carles, Pauline | Fleureau, Catherine | Joannes-Boyau, Olivier | Ouattara, Alexandre | Joseph, Adrien | Garrouste-Orgeas, Maïté | Max, Adeline | Lerin, Talia | Grégoire, Charles | Kloeckner, Martin | Bruel, Cédric | Brochon, Sandie | Philippart, Francois | Pichot, Emmanuelle | Simons, Clara | Flint, Andrew | Aubron, Cécile | Bellomo, Rinaldo | Pilcher, David | Cheng, Allen | Hegarty, Colin | Martinelli, Anthony | Howden, Benjamin | Reade, Michael | Mcquilten, Zoe | Bretonnière, Cédric | Villers, Daniel | Soares, M. | Gonzalez, Frédéric | Vincent, François | Fauché, Clémence | Gay, Samuel | Skowron, Olivier | Levrat, Albrice | Dorez, Didier | Decavèle, Maxens | Foucrier, Arnaud | Pease, Sebastian | Gauss, Tobias | Paugam, Catherine | Gorham, Julie | Ameye, Lieveke | Paesmans, Marianne | Berghmans, Thierry | Sculier, Jean-Paul | Meert, Anne-Pascale | Deras, Pauline | Martinez, Orianne | Latry, Pascal | Capdevila, Xavier | Charbit, Jonathan | Jaubert, J. | Etiennar, Celia | Ginoux, Lucie | Sebbah, Jean-Luc | Haouache, Hakim | Dhonneur, Gilles | Cheikh, Chaigar Mohammed | Moussaid, I. | Ghazaoui, O. | Belkadi, Kamal | El Youssoufi, S. | Salmi, S. | Pajot, Laure | Zuber, Benjamin | Darmon, Michael | Bedos, Jean Pierre | Dupont, Benoit | Eugène, Axelle | Galateau-Sallé, Françoise | Michard, Baptiste | Lebas, Benjamin | Boivin, Alexandra | Guillot, Max | Harlay, Marie-Line | Janssen-Langenstein, Ralf | Schenck, Maleka | Ellero, Bernard | Woehl-Jaegle, Marie-Lorraine | Besch, Camille | Castelain, Vincent | Bachellier, Philippe | Schneider, Francis | Camus, Christophe | Saliba, Fawzi | Goubaux, Bernard | Bonadona, Agnès | Lavayssiere, Laurence | Quinart, Alice | Barbot, Olivier | Dharancy, Sebastien | Delafosse, Bertrand | Barraud, Helene | Galbois, Arnaud | Veber, Benoit | Cayot, Sophie | Souche, Bruno | Locher, Clara | Roux, Olivier | Figorilli, Francesco | Putignano, Antonella | Houssel, Pauline | Francoz, Claire | Weiss, Emmanuel | Agarwal, Banwari | Jalan, Rajiv | Durand, François | Ghezala, Hassen Ben | Daoudi, Rebeh | Kaddour, Moez | Ghadhoune, Hatem | Rachedi, E. | Guissouma, J. | Ben Slimene, A. | Azzeza, W. | Brahmi, H. | Elghord, H. | Kada, Ahmed Youssef | Chikh, Radia | Slimani, Roza | a Bouyoucef, Kheireddine. | Regaieg, Kais | Kamilia, Chtara | Baccouche, Najeh | Turki, Olfa | Chaari, Anis | Ben, Hmida Chokri | Bouaziz, Mounir | Medhioub, Fatma Kaaniche | Zekri, Manel | Rgieg, Kais | Bhimada, Chokri | Mounir, Bouaziz | Cheikh, Chaigar Mohammed | Lang, Elodie | Welschbillig, Stephane | Perrin, Mathilde | Devys, Jean-Michel | Benbernou, Soumia | Mokhtari-Djebli, Houria | Ilies, Sofiane | Bouyacoub, Khalida | Azza, Abdelkader | Zogheib, Elie | Nader, Joseph | Villeret, Léonie | Guilbart, Mathieu | Besserve, Patricia | Caus, Thierry | Mastroianni, Ciro | Santi, Francesca | Hékimian, Guillaume | Pascal, Leprince | Chastre, Jean | Perrier, Virginie | Deniau, Benjamin | Klasen, Fanny | Ponthus, Jean Pierre | Ngasseu, Polysie | Amilien, Virginie | Barsam, Elise | Lehericey, Pierre | Tchir, Martial | Georger, Jean Francois | Puech, Bérénice | Vandroux, David | Roussiaux, Arnaud | Belcour, Dominique | Ferdynus, Cyril | Martinet, Olivier | Jabot, Julien | Fresco, Marion | Demeilliers-Pfister, Gaëlle | Merle, Véronique | Brunel, Valéry | Dureuil, Bertrand | Leydier, Sébastien | Clerc-Urmes, Isabelle | Lemarie, Jérémie | Maigrat, Charles-Henri | Cravoisy-Popovic, Aurélie | Barraud, Damien | Nace, Lionel | Gibot, Sébastien | Agrinier, Nelly | Bollaert, Pierre-Edouard | Daban, Jean-Louis | Boutonnet, Mathieu | Dumas, Guillaume | Falzone, Elisabeth | Jault, Patrick | Lenoir, Bernard | Makunza, Joseph Nsiala | Mejeni, Nathalie | Mazaud, Amélie | Béague, Sébastien | Rousselle, Anne-Flore | Durocher, Alain | Perez, Pauline | Grinea, Alexandra | Bedoui, Naoures | Stoian, Alina | Baboi, Loredana | Gobert, Florent | Yonis, Hodane | Tapponier, Romain | Bruyneel, Arnaud | Bonus, Thierry | Cuvelier, Grégory | Machayeckhi, Sharam | Olieuz, Sandra | Legrand, Alexandre | Feki, Fatma | Jamoussi, Amira | Merhebene, Takoua | Braham, Emna | Ghariani, Asma | Mezni, Faouzi El | Slim, Leila | Khelil, Jalila Ben | Besbes, Mohamed | Marchalot, Antoine | Beduneau, Gaetan | Carpentier, Dorothée | Besnier, Emmanuel | Gastaldi, Gioia | Abily, Julien | Beuzelin, Marion | Nay, Mai-Anh | Mankikian, Julie | Hervé, Virginie | Soulie, Marie | Cronier, Pierrick | Kantor, Elie | Federici, Laura | Gilbert, Marion | Mezhari, Ilham | Choukroun, Gérald | Marque, Sophie | Coppere, Z. | Fulgencio, Jean-Pierre | Blayau, Clarisse | Pham, Tai | Djibre, Michel | Reffienna, Matthieu | Lefort, Sébastien | Debue, Anne-Sophie | Daviaud, Fabrice | Cabon, Sarah | Addou, Zakaria | Douah, Ali | Moussati, Mohamed | Belhabiche, Kamel | Aouffen, Nabil | Soulier, Sylvie | Mauriat, Philippe | Tafer, Nadir | Mortamet, Guillaume | Amaddeo, Alessandro | Khirani, Sonia | Fauroux, Brigitte | Khanes, Gennadiy | Liutko, Olga | Bidnenko, Svitlana | Doye, Emilie | Voirin, Nicolas | Maucort-Boulch, Delphine | Kolev-Descamp, Karine | Aouane, Imane El | Essid, Aben | Hammami, Wallid | Haegy, Isabelle | Bataille, Jacques | Bergounioux, Jean | Morin, Luc | Ray, Samiran | Maclaren, Graeme | Nadel, Simon | Kneyber, Martin | Peters, Mark | Jansen, Koos | De Luca, Daniele | Wilson, Clare | Schlapbach, Luregn | Tissières, Pierre | Girard, Anne-Claire | Savajols, Elodie | Burguet, Antoine | Semama, Denis | Litzler-Renault, Stephanie | Fredj, Hana | Hassouna, Malek | Hechmi, Youssef Zied El | Cherif, Mohamed Ali | Zouheir, Jerbi | Dernane, Ahmed | Bouakkaz, Fouad | Taleb, Lhoucine Ben | Zeddine Mouhsen, A. | Lyazidi, Aissam | Richard, Jean-Christophe Marie | Mouhsen, Ahmed | Harmouchi, Mohammed | Rattal, Mourad | Huck, Matthias | Leclerc, Thomas | Donat, Nicolas | Cirodde, Audrey | Schaal, Jean-Vivien | Masson, Yannick | Hoffmann, Clément | Cerland, Laura | Valentino, Ruddy | Chabartier, C. | Villain-Coquet, Laurent | Ferge, Jean-Louis | Brouste, Y. | Mehdaoui, Hossein | Louriz, Maha | Madani, Naoufal | Amlaiky, Fatiha | Dendane, Tarek | Abidi, Khalid | Zekraoui, Aicha | Zeggwagh, Amine Ali | Abouqal, Redouane | Brahim, Affra | Ferhi, Fehmi | Bouslama, Mohamed Amine | Benjazia, Khaled | Zeineb, Abid | Mahassen, Dhaouadi | Cadiet, Julien | Ferron, Marine | Prat, Valentine | Erraud, Angelique | Aillerie, Virginie | Mevel, Mathieu | Grabherr, Amandine | Chatham, John C. | Gauthier, Chantal | Lauzier, Benjamin | Rozec, Bertrand | Joffre, Jeremie | Loyer, Xavier | Lavillegrand, Jean-Rémi | Zeboudj, Lynda | Laurans, Ludivine | Esposito, Bruno | Tedgui, Alain | Mallat, Ziad | Wei, Chaojie | Kattani, Narimane Al | Louis, Huguette | Orlowski, Sophie | Tharaux, Pierre-Louis | Burban, Mélanie | Meyer, Grégory | Olland, Anne | Yver, Blandine | Toti, Florence | Schini-Kerth, Valérie | Monnier, Alexandra | Leborgne, Pierrick | Meziani, Ferhat | Clavier, Thomas | Paulus, Mulder | Castel, Hélène | Richard, Vincent | Pons, Stéphanie | Skurnik, David | Six, Sophie | Jaffal, Karim | Vigneron, Clara | Large, Audrey | Bador, Julien | Aho, Serge | Prin, Sebastien | Touil, Yosr | Ayed, Soufia | Ali, Habiba Sik | Tilouch, Najla | Mateur, Houda | Talik, I. | Gharbi, Rim | Hassen, Mohamed Fekih | Elatrous, Souheil | Patry, Isabelle | Bertrand, Xavier | Zahar, Jean-Ralph | Essaied, Wafa | Wolkewitz, Martin | Soued, Mickaël | Cook, Fabrice | Lobo, David | Mounier, Roman | Emirian, Aurélie | Decousser, Jean Winoc | Slaoui, Mohamed Toufik | Benslama, Abdellatif | Valance, Dorothée | Allou, Nicolas | Allyn, Jérôme | Jean-Bart, Elodie | Bel., Floriane | Morey, Fabienne | Sedillot, Nicholas | Biard, Lucie | Galliot, Richard | Zunarelli, Romain | Gauzere, Bernard-Alex | Cartier, Jean-Charles | Jouve, Thomas | Hilleret, Marie-Noëlle | Hamidfar-Roy, Rebecca | Ara-Somohano, Claire | Minet, Clémence | Pourcelet, Aline | Hougardy, Jean-Michel | Defrance, Pierre | De Laforcade, Louis | Boyer, Alexandre | Gruson, Didier | Clouzeau, Benjamin | Hajjam, Najah | Nasri, Houda | Doghri, Hamdi | Mongardon, Nicolas | Levesque, Eric | Bastide, Marie-Anaïs | Richecoeur, Jack | Frenoy, Eric | Lemaire, Christian | Schortgen, Frédérique | Preau, Sebastien | Ehooman, Franck | Montlahuc, Claire | Bardon, Jean | Postel-Vinay, Nicolas | Lafi, Mehdi | Jacobs, Frédéric | Prat, Dominique | Le Meur, Matthieu | Moneger, Guy | Demars, Nadège | Trouiller, Pierre | Tencé, Noémie | Zaien, Inès | Wolf, Martine | Allardet-Servent, Jérôme | Lebsir, Melissa | Dubroca, Christian | Portugal, Mireille | Castanier, Matthias | Signouret, Thomas | Soundaravelou, Rettinavelou | Lepidi, Anne | Halfon, Philippe | Seghboyan, Jean-Marie | Gamblin, Camille | Benturquia, Nadia | Roussel, Olivier | Chevillard, Lucie | Risede, Patricia | Callebert, Jacques | Khelfa, Messaouda | Blel, Youssef | Thabet, H. | Brahmi, Nozha | Amamou, M. | Le Louët, A. Lillo- | Baud, F. | Le Beller, C. | Vivien, B. | Soufir, L. | Carli, P. | Le Louët, H. | Essafi, Fatma | Foudhaili, Nasreddine | Slimen, Abdelaziz Ben | Jabla, Rami | Hammed, Hedia | Marzouk, Mahdi | Boujelbene, Nesrine | Dachraoui, Fahmi | Hachani, Asma | Abdallah, Saousen Ben | Lakhal, Hend Ben | Ghribi, Chaima | Ali, Imen Ben | Abdellaoui, Imen | Ouanes-Besbes, Lamia | Abroug, Fekri | Demiri, Suela | Lorut, Christine | Van Lang, Daniel Luu | Lefebvre, Aurélie | Alifano, Marco | Reignard, Jean-Francois | Samama, Marc | Dusser, Daniel | Roche, Nicolas | Réminiac, François | Landel, Cassandre | Gensburger, Samuel | Bocar, Thomas | Mordier, Lydiane | Philippe, Marion | Le Pennec, Déborah | Vecellio, Laurent | Ehrmann, Stephan | Poiroux, Laurent | Thevoz, David | Simons, Julien | Roeseler, Jean | Loiez, Anthéa | Gérard, Stéphanie | Dousse, Nicolas | L’hotellier, Sylvie | Baumgarten, Elodie | Borschneck, Stéphanie | Kharcha, Fatima | Ghander, Cécile | Tresallet, Christophe | Puymirat, Etienne | Fagon, Jean-Yves | Aegerter, Philippe | Diehl, Jean-Luc | Hauw-Berlemont, Caroline | Chatellier, Gilles | Danchin, Nicolas | Aissaoui, Nadia | Aissat, Nadia | Bernard, R. | Amour, Julien | Bouglé, Adrien | Vidal, Charles | Nima, Djavidi | Shaida, Varnous | Dorget, Amandine | Bréchot, Nicolas | Toufiki, Rabi | Mouaffak, Youssef | Adib, Ahmed Rhassan El | Amine, M. | Moumine, S. | Jonard, Marie | Ducloy-Bouthors, Anne Sophie | Bouju, Pierre | Barbarot, Nicolas | Gacouin, Arnaud | Fillatre, Pierre | Grillet, Guillaume | Goepp, Angélique | Clairet, Anne-Laure | Limat, Samuel | Cornette, Christian | Fatnassi, Amira | Romdhani, Chiheb | Sammoud, Walid | Labbene, Iheb | Ferjani, Mustapha | Taibi, Hind | Elatiqi, Ijlal | Iraqui, A. | Cherkab, Rachid | Haddad, Wafae | Elkettani, Chafik | Barrou, Lahoucine | Cave, Fabien | Lerolle, Nicolas | Doutrellot, Pierre Louis | Vaysse, Benoit | Inan, M. | Khelfoun, K. | Nasserallah, M. | Maizel, Julien | Legrand-Monteil, C. | Tasseel-Ponche, S. | Kowalski, Benjamin | Guaguere, Anne | Boulle-Geronimi, Claire | Masse, Juliette | Vanbaelinghem, Clément | Herbecq, Patrick | Mokline, Amel | Draief, Syrine | Gharsallah, Lazhari | Rahmani, Imen | Gasri, Bahija | Tlaili, Sofiene | Hammouda, Rym | Messadi, Amen Allah | Michel, Philippe | Gelée, Bruno | Fadel, Fouad | Thuong, Marie | Ait-Aoudia, Sandra | Laddi, Salima | Sahraoui, Mohamed-Mohcen | Muller, Michel | Faucher, Anna | Hermann, Bertrand | Berlemont, Caroline Hauw | Arnaout, Michel | Busson, Julie | Dhumeaux, Julie | Ericher, Nicole | Lucas, Pierre | Dumas, Magalie | Chapelle, Celine | Philippon-Jouve, Benedicte | Morel, Jerome | Beuret, Pascal | Bureau, Côme | Poitou, Tymothée | Coudroy, Remi | Petua, Philippe | Ghezala, Hassen Ben | Prades, Albert | Basty, Marion | Monet, Clément | Mounet, Benjamin | Futier, Emmanuel | Leroux, Audrey | Oudinot, Xavier | Laurent, Marc | Ouanes, Islem | Jochmans, Sebastien | Alphonsine, Jean-Emmanuel | Van Vong, Ly | Rolin, Nathalie | Sy, Oumar | Serbource-Goguel, Jean | Ellrodt, Olivier | Monchi, Mehran | Bahloul, Mabrouk | Olfa, Turki | Chokri, Benhamida | Chelly, Hedi | Trichot, Amélie | Colin, Gwenhaël | Vinatier, Isabelle | Bachoumas, Konstantinos | Lacherade, Jean-Claude | Fiancette, Maud | Joret, Aurélie | Yehia, Aihem | Henry-Laguarrigue, Matthieu | Martin-Lefèvre, Laurent | Razazi, Keyvan | Surenaud, Mathieu | Bedet, Alexandre | Seemann, Aurelien | Hüe, Sophie | Clere-Jehl, Raphaël | Charles, Anne-Laure | Geny, Bernard | Bilbault, Pascal | Bourcier, Simon | Lejour, Gabriel | Bourcier, Simon | Boêlle, Pierre Yves | Safaa, Nemlaghi | Paulus, Sylvie | Flamens, Claire | Neidecker, Jean | Rambaud, Jerome | Allioux, Cecile | Guedj, Romain | Guellec, Isabelle | Guilbert, Julia | Leger, Pierre-Louis | Demoulin, Maryne | Durandy, Amélie | Jean, Sandrine | Carbajal, Ricardo | Morand, Aurélie | Zieleskiewicz, Laurent | Brissaud, Olivier | Le Bel, Stéphane | Meresse, Zoé | Panuel, Michel | Thomachot, Laurent | Leone, Marc | Michel, Fabrice | Deho’, Anna | Sadozai, Laïly | Dauger, Stéphane | Prot-Labarthe, Sonia | Genuini, Mathieu | Florence, Moulin | Treluyer, Jean-Marc | Renolleau, Sylvain | Chalavon, Emmanuelle | Dessein, Rodrigue | Grandbastien, Bruno | Pesin, Sarah | Dubos, François | Leteurtre, Stéphane | Puel, Marie-Aude | Szulc, Marie | Philippe, Anais | Severac, François | Astruc, Dominique | Kuhn, Pierre | Desprez, Philippe | Aoul, Nabil Tabet | Colomb, Benoît | Petion, Anne Marie | Queudet, Laurent | Remy, Solenn | Youssef, Mouaffak | Roumeliotis, Nadia | Dong, Christian | Pettersen, Geraldine | Crevier, Louis | Emeriaud, Guillaume | Naudin, Jérôme | Abdallah, Laetitia | Ganier, Marion | Frannais, Karine | Douglas, Dylia | Flusin, Cecile | Brossier, David | Eltaani, Redha | Sauthier, Michaël | Guillois, Bernard | Rambaud, Jerome | Larroquet, Michelle | Amblard, Alain | Lode, Noella | Casadevall, Isabelle | Kessous, Katia | Walti, Hervé | Poiré, Christophe | Chen, Huixiong | Megarbane, Bruno | M’rad, A. | Habacha, Sahar | Chatbri, Bassem | M’rad, A. | Masniere, Cyril | Megarbane, Bruno | M’rad, A. | Souissi, Samar | Ghord, Hatem El | Kouraichi, N. | Brahmi, N. | Marhbène, Takoua | Mejri, Islam | Lakhdar, Douha | Merhabane, Takoua T. | la Maamouri, Hé | Charlotte, Oestreicher | Wegelius, Helena | Landelle, Caroline | Schrenzel, Jacques | Kaiser, Laurent | Pugin, Jérôme | Belhadj, Hind | Chanareille, Paul | Ladureau, Adélie | Sanna, Alice | Rolle, Amélie | Pons, Bertrand | Piednoir, Pascale | Ardisson, Fanny | Martino, Frédéric | Bernos, Thomas | Elkoun, Khalid | Elain, Elie | Lawson, Roland | Resh-Rigon, Matthieu | Belorgey, Sophie | Thiery, Guillaume | Berlemont, Caroline Hauw | Pricopi, Cyprian | Barthes, Françoise | Doddie, Thansya | Nsiala, Mj | Situakibanza, Nh | Amisi, Be | Kazadi, Mj | Kilembe, Ma | Clement, Christophe | Lamontagne, François | Boyer, Valérie Nocquet | Naimo, Sébastien | Raulais, Ronan | Genevois, Emilie | Bouchoud, Lucie | Boroli, Filippo | Abidi, Nour | Abbas, Mohamed | Harbarth, Stefan | Pugin, Jérôme | Charles, Pierre-Emmanuel | Dereux, Caroline | De Guillebon, Stanislas | Morisse, Eloise | France, Julie | Gasser, Deborah | Badia, Philippe | Picard, Walter | Corne, P. | De Boulastel, I. | Seguin, S. | Blasco, A. | Ledur, V. | Jonquet, Olivier | Sophie, Paktoris-Papine | Artiguenave, Margaux | Sayed, Faten El | Espinasse, Florence | Dinh, Aurélien | Charron, Cyril | Lebas, Benjamin | Hatsch, Sophie | Maestraggi, Quentin | Dureau, Anne-Florence | Faitot, François | Margetis, Dimitri | Bouvet, Odile | Chevret, Didier | Denamur, Erick | Simonet, Justine | Vest, Philippe | Peigne, Vincent | Couffin, Severine | Cheikh Bouhlel, M. | Khedher, Ahmed | Meddeb, Kaoula | Azouzi, A. | Hamdaoui, Y. | Ayachi, Jihene | Brahim, W. | Bouneb, Rania | Boussarsar, Mohamed | Florens, Nans | Varéon, Julie | Malatray, Arnaud | Argaud, Laurent | Dupland, Pierre | Vergier, Romain | Issaurat, Pauline | Estagnasié, Philippe | Squara, Pierre | Brusset, Alain | Génin, Vincent | Jendoubi, Ali | Jlassi, Rifka | Hamrouni, Bassem | Marzougui, Yahia | Kouka, Jihen | Ghedira, Salma | Houissa, Mohamed | Dhifaoui, Kaouther | Hajjej, Zied | Oziel, Johanna | Dinh, Alexy Tran | Neulier, Caroline | Amara, Marlène | Nebot, Nicaise | Troché, Gilles | Breton, Nelly | Cavelot, Sébastien | Pangon, Béatrice | Merrer, Jacques | Labaste, François | Conil, Jean-Marie | Grossac, Julia | Ruiz, Stéphanie | Grare, Marion | Minville, Vincent | Georges, Bernard | Van Der Meersch, Guillaume | Karoubi, Philippe | Huang, Christophe | Carbonne, Helene | Amarsy, Rishma | Mateo, Joaquim | Von Edelsberg, Sophie Leloup | Vercheval, Christelle | Damas, Pierre | Bouguerra, Chaker | Naas, Noura | Muller, Joris | Schaeffer, Mickael | Loc, Pierre Tran Ba | Deboscker, Stéphanie | Harley, Marie-Line | Lavigne, Thierry | Brunet, Jennifer | Canoville, Bertrand | Lellouche, François | L’her, Erwan | Bouchard, Pierre Alexandre | Delorme, Mathieu | Elfaramawy, Tamer | Gosselin, Benoit | Guegan, Sarah | Michotte, Jean-Bernard | Staderini, Enrico | Dugernier, Jonathan | Rusu, Rares | Liistro, Giuseppe | Reychler, Gregory | Delorme, Mathieu | Simon, Mathieu | Essoukaki, Elmaati | Duprez, Frédéric | Michotte, Jean Bernard | Contal, Olivier | Trabelsi, Becem | Hajjej, Zied | Garsallah, Hedi | Hajjej, Zied | Harira, Khaoula | Rafat, Cédric | Mariotte, Eric | Le Jeune, Caroline | Roy, Pascal | Michallet, Mauricette | Zerbib, Yoann | Baudin, François | Blot, François | Bornstain, Caroline | Gelinotte, Stéphanie | Rigaud, Jean-Philippe | Tamion, Fabienne | Bouteloup, Marie | Darmon, Michaël | Nouira, H. | Boisramé-Helms, Julie | Degirmenci, Su | Kummerlen, Christine | Delile, Eugénie | Thiébaut, Pierre-Alain | Do Rego, Jean-Claude | Coquerel, David | Nevière, Rémi | Ichou, Laure | Carbonell, Nicolas | Rautou, Pierre-Emmanuel | Nousbaum, Jean-Baptiste | Renou, Christophe | Anty, Rodolphe | Landraud, Luce | Ait-Oufella, Hafid | Coudroy, Remi | Lecron, Jean-Claude | Helary, Michael | Paillot, Jonathan | Pili-Floury, Sebastien | Khedher, Sana | Maoui, Amira | Ezzamouri, Asma | Salem, Mohamed | Kerdjana, Lamia | Dumitrescu, Mihaela | Mimoz, Olivier | Debaene, Bertrand | Migeot, Virginie | Dahyot-Fizelier, Claire | Khedher, Sana | maoui, Amira A. | Champigneulle, Benoit | Zafrani, Lara | Lascarrou, Jean-Baptiste | Lissonde, Floriane | Le Thuaut, Aurélie | Reignier, Jean | Platon, Laura | Lambert, Jerôme | Lagier, David | Brun, Jeanpaul | Sannini, Antoine | Chow-Chine, Laurent | Bisbal, Magali | Faucher, Marion | Mokart, Djamel | la Mourtada, Leï | Virgnie, Lemiale | Gaudet, Alexandre | Parmentier-Decrucq, Erika | De Freitas Caires, Nathalie | Dubucquoi, Sylvain | Lassalle, Philippe | Mathieu, Daniel | Richard, Jean-Christophe | Tapponnier, Romain | Quintin, Luc | Pichot, C. | Petitjeans, F. | Guillon, Antoine | Jouan, Youenn | Breah, Daborah | Gueugnon, Fabien | Dalloneau, Emilie | Baranek, Thomas | Henry, Clemence | Morello, Eric | Renauld, Jc | Pichavant, M. | Gosset, Philippe | Courty, Y. | Diot, Patrice | Si-Tahar, Mustapha | Tadié, Jean-Marc | Vuillard, Constance | La Combe, Béatrice | Ponsin, Pauline | Boddaert, Guillaume | Grand, Bertrand | Baudoin, Yohan | Bonnet, Stéphane | Snouda, Salah | Abbes, Mohamed Fehmi | Benchiekh, Imen | Cheikh, Chaigar Mohammed | Sedghiani, Ines | Maaroufi, Neila | Belayachi, Jihane | Debono, Leila | Auvet, Adrien | Nadal-Desbarats, Lydie | Tankovic, Jacques | Dahoumane, Redouane | Oufella, Hafid Ait | Offenstadt, Georges | Filali, Amel | Faure, Emmanuel | Van Grunderbeeck, Nicolas | Nigeon, Olivier | Bazus, H. | Mallat, Jihad | Thevenin, Didier | Lempereur-Legros, Sophie | Ledoux, Didier | Nys, Monique | Hajjej, Zied | Messika, Jonathan | Clermont, Olivier | Aubry, Alexandra | Fernandes, Romain | Venot, Marion | Bailly, Sébastien | Garnaud, Cécile | Cornet, Muriel | Pavese, Patricia | Foroni, Luc | Boisset, Sandrine | le Maubon, Daniè | Ouanes, Islem | Abid, Maha | Ezzouine, Hanane | Edith, Constant Aniolo | Sztrymf, Benjamin | Brunot, Vincent | Serre, Jean-Emmanuel | Landreau, L. | Boussarsar, Mohamed | Ouanes, Islem | Jean-Michel, Vanessa | Couturaud, Francis | Moore, Elizabeth | Egreteau, Pierre-Yves | Boles, Jean-Michel | Herbrecht, Jean-Etienne | Kaeuffer, Charlotte | Meyer, Anne | Mokline, Amel | Arfi, Khaouther Ben | Lesage, Fabrice | Séguret, Sylvie | Dupic, Laurent | De Saint Blanquat, Laure | Baptiste, Anne-Sophie | Georges, Hugues | Delannoy, Pierre-Yves | Devos, Patrick | Albarracin, Dolores | Ducousso-Lacaze, A. | Dufour, Julien | Cabasson, Séverin | Veinstein, Anne | Chatellier, Delphine | Robert, René | Ha, Vivien Hong Tuan | Lau, Nicolas | Mimoun, Lucie | Forceville, Xavier | Maamar, Adel | Chevalier, Stéphanie | Botoc, Vlad | Rouleau, Stephane | Desachy, Arnaud | Calvat, Sylvie | Lafon, Charles | Cracco, Christophe | Van Grunderbeeck, Nicolas | Temime, J. | Molmy, Perrine | Gasan, G. | Béranger, Agathe | Chappuy, Hélène | Bertrand, Pierre-Marie | Beurton, Alexandra | Bodet-Contentin, Laetitia | Boisramé-Helms, Julie | Danin, Pierre-éRic | Dubois, Elsa | Karaca, Yasemin | Mora, Pierre | Vodovar, Dominique | Desbrosses, Yohan | Chauchet, Adrien | Daguindau, Etienne | Deconinck, Eric | Chermak, Akli | Baron, Marinne | Calvet, Laure | Sapin, Anne Françoise | Pereira, Bruno | Vettoretti, Lucie | Lacroix, Jacques | Clayton, Lucy | Sabri, Elham | Bardiaux, Laurent | Tiberghien, Pierre | Hebert, Paul | Lengliné, Etienne | Venot, Marion | Socié, Gérard | Borcoman, Edith | Rusinova, Katerina | Del Galy, Aurélien Sutra | Mercier, Mélanie | Hamel, Jean-François | Raveau, Tommy | Moles, Marie-Pierre | Clavert, Aline | Hunault-Berger, Mathilde | Ifrah, Norbert | Schmidt-Tanguy, Aline | Carreira, Serge | Lavault, Sophie | Pallanca, Olivier | Morawiec, Elise | Arnulf, Isabelle | D’humières, Thomas | Carrié, Cédric | Gisbert-Mora, Chloé | Bonnardel, Eline | Biais, Matthieu | Hilbert, Gilles | Bureau, Côme | Joannon, Thomas | Marincamp, Aude | Chiche, Jean-Daniel | Ferre, Alexis | Lichtenstein, Daniel | Meziere, Gilbert | Dres, Martin | Gonzalez, Céline | Vignon, Philippe | Hamzaoui, Olfa | Geffriaud, Thomas | Leleu, François | Maizel, Julien | Boissier, Florence | Cuquemelle, Elise | Lim, Pascal | Amara, R. | Boussarsar, Mohamed | Léger, Julie | Jacob, Christophe | Bouferache, Koceila | Vignon, Philippe | Ragot, Claire | Corradi, Laure | Maizel, Julien | Maurice, Laure | Julliand, S. | Deho, Anna | Le Bourgeois, Fleur | Jacquot, Aurelien | Valla, Frederic | Letois, Flavie | Salvadori, Alexandre | Ottonello, Gaia | Blanot, Stéphane | Montmayeur, Juliette | Orliaguet, Gilles | Tarmiz, Khalil | Habas, Flora | Baleine, Julien | Lebouhellec, Julia | Combes, Clementine | Chomton, Maryline | Jouvet, Philippe | Ranchin, Bruno | Macher, Marie Alice | Gaillot, Théophile | Bahloul, Mabrouk | Moine, Murielle | Ageron, François Xavier | Jannel, Claire | Debillon, Thierry | Wroblewski, Isabelle | Duprey, Matthieu | Jarlier, Vincent | Luyt, Charles-Edouard | Bailly, Sébastien | Longval, Thomas | Schnell, David | Padoin, Christophe | Cohen, Yves | Mokline, Amel | Gaies, Emna | Triki, Sameh | Klouz, Anis | Moussa, Mouhamed | Desrumaux, Flavie | May, Faten | Perrin, Marion | Nguyen, Jean-Claude | Tiercelet, Kelly | Fournier, Julien | Cherin, Mélanie | Kitzis, Marie Dominique | Misset, Benoit | Mathien, Cyrille | Poidevin, Antoine | Donatti, Luis | Mootien, Joy | Pinto, Luis | Egard, Mathieu | Bodur, Gokhan | Barberet, Guillaume | Ionescu, Carmen | Ganster, Frederique | Guiot, Philippe | Kuteifan, Khaldoun | Mpela, Alain | Chelly, Jonathan | Guérin, Laurent | Persichini, Romain | Hullin, Thomas | Deye, Nicolas | Aubertein, Pierre | Paul, Marine | Bougouin, Wulfran | Sandroni, Claudio | Passouant, Olivier | Geri, Guillaume | Llitjos, Jean-François | Chenevier-Gobeaux, Camille | Batteux, Frederic | Llitjos, Jean-François | Drouet, Ludovic | Voicu, Sebastian | Henry, Patrick | Dillinger, Jean-Guillaume | Bougouin, Wulfran | Resiere, Dabor | Dessoy, A. L. | Soyer, Benjamin | Faivre, Valérie | Damoisel, Charles | Soyer, Benjamin | Stiel, Laure | Galoisy, Anne-Cécile | Mauvieux, Laurent | Zobairi, Fatiha | Angles-Cano, Eduardo | Stiel, Laure | Piau, Caroline | Tadié, Jean-Marc | Daix, Thomas | Jeannet, Robin | Feuillard, Jean | Jolly, Lucie | Boufenzer, Amir | Carrasco, Kevin | Derive, Marc | Gibot, Sebastien | Merdji, Hamid | Belaidouni, Nadia | Toubiana, Julie | L’Hermitte, Yann | Woimant, France | Oppenheim, Catherine | Couvreur, Christophe | Dolveck, François | Devriese, Magali | Dupeyrat, Sophie | Ray, Patrick | Lefevre, Guillaume | Fartoukh, Muriel | Roothaer, Nicolas | Carpentier, Amélie | Vaniet, Fabien | Maisonneuve, Antoine | Wiel, Eric | Canu, Sébastien | Hammad, Emmanuelle | Antonini, Francois | Poirier, Marion | Vigne, Coralie | Haddam, Malik | Alingrin, Julie | Dangers, Laurence | Mangiapan, Gilles | Huet, Isabelle | Dhalluin, Xavier | Bautin, Nathalie | Quiot, Jean Jacques | De Vecchi, Corinne Appere | Chenivesse, Cécile | Tarmiz, Khalil | Medhioub, Fatma Kaaniche | Smaoui, Mariem | Cheikh, Chaigar Mohammed | El Alami, E. | Weiss, Nicolas | Mochel, Fanny | Galanaud, Damien | Puybasset, Louis | Lodey, Marion | Guiller, Elsa | Weiss, Nicolas | Silva, Stein | Vuillaume, Corine | De Pasquale, Francesco | Demonet, Jean Francois | Sinnah, Fabrice | Dalloz, Marie Amelie | D’ortho, Marie Pia | Rouvel-Tallec, Anny | Couret, David | Catan, Aurélie | Nativel, Brice | Planesse, Cynthia | Diotel, Nicolas | Meilhac, Olivier | Roy-Gash, Fabian | Lebard, Christophe | Larbi, Anne-Gaelle Si | Gaudin, Virginie | Bonnin, France | Sultan, Oceane | Hoc, Cecile | Mathieu, Emmanuel | Lapergue, Bertrand | Bourdain, Frederic | Caron, Margot | Parrot, Antoine | Labbe, Vincent | Hafiani, El Mahdi | Quesnel, Christophe | Genay, Stephanie | Décaudin, Bertrand | Ethgen, Sabine | Odou, Pascal | Lebuffe, Gilles | Gaudry, Stéphane | Aubron, Cécile | Mcquilte, Zoe | Garrouste-Orgeas, Maïté | Soufir, Lilia | Allaouchiche, Bernard | Verdière, Bruno | Nyunga, Martine | Banaias, Noémie | Colling, Delphine | Kauv, Marie | Blondeau, Erik | Ouanes, Islem | Auclin, Edouard | Haw-Berlemont, Caroline | Taieb, Julien | Oudard, Stéphane | Morissette, Genevieve | Kechaou, Wassim | Litalien, Catherine | Merouani, Aïcha | Phan, Véronique | Bouchard, Josée | Starck, Julie | Briand, Nelly | Sachs, Philippe | Angoulvant, François | Sommet, Julie | Holvoet, L. | Benkerrou, M. | Dreyfus, Lélia | Bordet, Fabienne | Touzet, Sandrine | Denis, Angélique | Le Coz, Julien | Chéron, Gérard | Nabbout, Rima | Patteau, Geraldine | Heilbronner, Claire | Hubert, Philippe | Oualha, Mehdi | Aoul, Nabil Tabet | Crulli, Benjamin | Toledano, Baruch | Poirier, Nancy | Vobecky, Suzanne | Khouadja, Hosni | Robert, René | Vinet, M. | Vinclair, Camille | Boisramé-Helms, Julie | Beloncle, François | Radermacher, Peter | Asfar, Pierre | Coupez, Elisabeth | Bohé, Julien | Shinotsuka, Cláudia Righy | Caironi, Pietro | Villois, Paola | Fontana, Vito | Creteur, Jacques | Pourcine, Franck | Vong, Ly | Weyer, Claire Marie | Akando, Benoit | Abdallah, Razach | Wetzstein, Morgane | Maizel, Julien | Antier, Nadiejda | Serroukh, Yasmina | Boudjeltia, Karim Zouaoui | Joosten, Anne | Rousseau, Alexandre | Delabranche, Xavier | Grunebaum, Lélia | Delabranche, Xavier | Mootien, Yoganaden | Gaci, Rostane | Garric, Jean-Romain | Delbove, Agathe | Darreau, Cédric | Dargent, Auguste | Soudry-Faure, Agnès | De Chambrun, Marc Pineton | Demondion, Pierre | Blanchard, Jean-Christophe | Chocron, Sydney | Meneveau, Nicolas | Corsi, Filippo | Meynieu, Pierre-Emmanuel | Repusseau, Benjamin | Germain, Arnaud | Baudry, Guillaume | Hierle, Lucie | Besch, Guillaume | Thomas, Guillemette | Cassir, Nadim | Dizier, Stéphanie | Roch, Antoine | Trebbia, Grégoire | Govindaradjou, Kiruba | Devaquet, Jérôme | Picard, Clément | Parquin, François | Leguen, Morgan | Felten, Marie-Louise | Sage, Edouard | Chapelier, Alain | Decavèle, Maxens | Duruisseaux, Michael | Fleury, Jocelyne | Antoine, Martine | Carette, Marie-France | Wislez, Marie | Givel, Claire | De Margerie-Mellon, Constance | De Kerviler, Eric | Tandjaoui-Lambiotte, Yacine | Freynet, Olivia | Kimmoun, Antoine | Baux, Elisabeth | Das, Vincent | Talec, Patrice | Anguel, Nadia | Louis, Guillaume | Girerd, Nicolas | Tallon, Pauline | Hadchouel-Duvergé, Alice | Salvi, Nadège | Cairet, Pascale | Delacourt, Christophe | Blandine, Blandine Lefebvre | Beraud, Laurence | Coppere, Zoé | Lamaziere, Antonin | Lionnet, François | Fartoukh, Muriel | Lehingue, Samuel | D’journo, Xavier | Jean-Marie, Forel | Thibault, Ronan | Makhlouf, Anne-Marie | Mulliez, Aurélien | Gonzalez, Cristina | Dadet, Sylvain | Kekstas, Gintautas | Preiser, Jean-Charles | Rotovnik, Kozjek Nada | Rozalen, Isabel Ceniceros | Kupczyk, Kinga | Krznaric, Zeljko | Cano, Noël | Pichard, Claude | Le Roux, Bénédicte Gaillard- | Jotterand, Corinne | Rooze, Shancy | Moullet, Clemence | Henin, Aurélia | Ettori, Florence | Zemmour, Christophe | Boher, Jean Marie | Arnaout, Michel | Feltry, Audrey | Ben, Salah Adel | Audibert, Juliette | Conia, Alexandre | Gontier, Olivier | Hamrouni, Mouldi | Lherm, Thierry | Ouchenir, Abdelkader | Rétif, Jérôme | Proudhom, Alain | Lagardere, Chantal | Tissot, Stéphane | Kalfon, Pierre | Sacre, Lynn | Villa, Antoine | Khadija, Alaywa | Garnier, Robert | Baud, Frederic | Baud, Frederic | Vasset, Brigitte | Heinzelman, Annette | Baud, Frederic | Jouffroy, Romain | Durand, Elsa Démarest | Compagnon, Patricia | Maaroufi, Neila | M’rad, A. | Jebri, Alia | Ghezala, Hassen Ben | Legout, Céline | Baud, Frederic | Castot-Villepelet, Anne | Valade, Sandrine | Lesieur, Olivier | Delmas, Benjamin | Visseaux, Benoit | Cohen, Johana | Nguyen, Liem Binh Luong | Morbieu, Caroline | Burdet, Charles | Lescure, François-Xavier | Armand-Lefevre, Laurence | Yazdanpanah, Yazdan | Houhou-Fidouh, Nadira | Cazaux, Marine | Goff Jérôme, Le | Meignin, Veronique | Boutboul, David | Rispail, Philippe | Brunot, Vincent | Besnard, N. | Ceballos, Patrice | Stoclin, Annabelle | Rotolo, Federico | Wartelle, Muriel | Hicheri, Yosr | Maillet, Sylvia | Chachaty, Elisabeth | Pignon, Jean-Pierre | Venot, Marion | Delorme, Mathieu | Bialais, Emilie | Julie, Dupuis | Paoloni, Laura | Wittebolle, Xavier | Hickmann, Cheryl | Castanares-Zapatero, Diego | Tordeur, Antoine | Colmant, Lise | Wittebole, Xavier | Tirone, Giuseppe | Laterre, Pierre-François | Ducroux, Lorraine | Kemlin, Claire | Moulton, Eric | Rosso, Charlotte | Le Neindre, Aymeric | Mongodi, Silvia | Bouhemad, Béaïd | Rodrigues, Joana | Botteau, Caroline | Duprez, Frédéric | Waroquier, François | Christiaens, Karel | Vantrimpont, Frank | Duprez, Frédéric | Elkhawand, Charbel | Vermeesh, Frank
Annals of Intensive Care  2016;6(Suppl 1):50.
Table of contents
PHYSICIANS ABSTRACTS
O1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized controlled study (BEST CUFF)
Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacori, Isabelle Alves, Stephanie Barrailler, Laurent Robriquet, Fabienne Tamion, Emmanuel Delaporte, Damien Thellier, Claire Delcourte, Alain Duhamel, Saad Nseir
O2 Bicarbonate versus saline for contrast-induced acute kidney injury prevention in critically ill patients
Xavier Valette, Isabelle Desmeulles, Benoit Savary, Romain Masson, Amélie Seguin, Cédric Daubin, Bertrand Sauneuf, Jennifer Brunet, Pierre Verrier, Véronique Pottier, Marie Orabona, Désiré Samba, Gérald Viquesnel, Mathilde Lermuzeaux, Pascal Hazera, Jean-Luc Hanouz, Jean-Jacques Parienti, Damien Du Cheyron
O3 Neurally adjusted ventilatory assist in the early phase of weaning from mechanical ventilation: a multicenter randomized study
Alexandre Demoule, Marc Clavel, Camille Rolland-Debord, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Florent Wallet, Hadrien Roze, Frédéric Vargas, Claude Guérin, Jean Dellamonica, Samir Jaber, Thomas Similowski
O4 Very high volume hemofiltration with the Cascade system in septic shock patients
Jean-Pierre Quenot, Christine Binquet, Christophe Vinsonneau, Saber-Davide Barbar, Sandrine Vinault,, Valérie Deckert, Stephanie Lemaire, Ali Ait Hssain, Rémi Bruyère, Bertrand Souweine, Laurent Lagrost, Christophe Adrie
O5 Effect of rapid response systems on hospital mortality, a prospective interventional study and systematic review
Boris Jung, Aurelien Daurat, Audrey De Jong, Gérald Chanques, Martin Mahul,, Marion Monnin, Nicolas Molinari, Samir Jaber
O6 Beta-lactams serum concentrations in critically ill cirrhotic patients: a matched control study
Olivier Lheureux, Eric Trepo, Maya Hites, Frederic Cotton, Fleur Wolff, Rudy Surin, Jacques Créteur, Jean-Louis Vincent, Thierry Gustot, Frederique Jacobs, Fabio Silvio Taccone
O7 Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: Risk factors and side effects
Mathilde Neuville, Jean-François Timsit, Najoua El-Helali, Alban Le Monnier, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Romain Sonneville, Lila Bouadma, Bruno Mourvillier
O8 Amikacin peak concentrations in patients receiving extracorporeal membrane oxygenation (ECMO) support: a case–control study
Elodie Gélisse, Mathilde Neuville, Etienne De Montmollin, Guillaume Voiriot, Jean-François Soubirou, Roland Smonig, Aguila Radjou, Eric Magalhaes, Lila Bouadma, Bruno Mourvillier, Jean-François Timsit, Romain Sonneville
O9 A high aminoglycoside regimen associated with renal replacement therapy for the treatment of multi-drug-resistant pathogens
Alexandre Brasseur, Maya Hites, Sandrine Roisin, Frederic Cotton, Jean-Louis Vincent, Daniel De Backer, Frederique Jacobs, Fabio Silvio Taccone
O10 Optimization of administration of vancomycin in septic patients: a prospective randomized study
Valerie Van Ruychevelt, Eric Carlier, Michael Piagnerelli, Michel Vanhaeverbeek, Christine Danguy, Patrick Biston
O11 Impact of elevated intra-abdominal pressure on the ability of dynamic parameters to predict fluid responsiveness
Siu-Ming Au, Emmanuelle Begot, François Dalmay, Xavier Repessé, Gwenael Prat, Koceila Bouferrache, Michel Slama, Philippe Vignon, Antoine Vieillard-Baron
O12 Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis
Xavier Monnet, Paul Marik, Jean-Louis Teboul
O13 Predicting volume responsiveness by using combined end-expiratory and end-inspiratory occlusion tests with echocardiography
Mathieu Jozwiak, Jean-Louis Teboul, Christian Richard, Xavier Monnet
O14 Early dynamic left intraventricular obstruction is associated with hypovolemia and hight mortality in septic shock patients
Jean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, Julien Maizel, Michel Slama
O15 Predictive factors for poor hemodynamic tolerance to fluid removal in ICU: the DepleRea study
François Brazier, Pablo Mercado, Loay Kontar, Dimitri Titeca, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien Maizel
O16 High-flow nasal cannula: first-line treatment of noninvasive ventilation for infants with bronchiolitis. Applicability and risk factors for failure
Camille Guillot, Claire Le Reun, Marie Lampin, Ahmed Sadik, Astrid Botte, Alain Duhamel, Stéphane Leteurtre
O17 Is high-flow nasal cannula better than nasal continuous positive airway pressure for bronchiolitis management in pediatric intensive care unit?
Aurélie Collins, Céline Kempeneers, Nathalie Cajgfinger
O18 Interest and risk of high-flow cannula during acute hypoxemic pneumonia in children: a retrospective study
Camille Ohlmann, Robin Pouyau, Fabien Subtil, Florent Baudin, Bruno Massenavette, Etienne Javouhey
O19 Interest of high-flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) during the initial management of severe bronchiolitis in infants: a multicenter randomized controlled trial
Christophe Milesi, Sandrine Essouri, Robin Pouyau,, Jean-Michel Liet, Mickael Afanetti, Julien Baleine, Sabine Durand, Philippe Durand, Etienne Javouhey, Jean Christophe Roze, Didier Dupont, Gilles Cambonie
O20 Outcome of severe cerebral venous thrombosis in intensive care unit: a cohort study
Benjamin Soyer, Marco Rusca, Anne-Claire Lukaszewicz, Isabelle Crassard, Jean-Pierre Guichard, Damien Bresson, Didier Payen de la Garanderie
O21 Brain lesion spectrum characterization in an experimental model of infective endocarditis
Marie Cantier, Candice Sabben, Liliane Louedec, Sandrine Delbosc, Clément Journé, Phalla Ou, Isabelle Klein, Françoise Chau, Agnes Lefort, Jean-Philippe Desilles, Jean-Baptiste Michel, Romain Sonneville, Mikaël Mazighi
O22 Outcome of patients with Parkinson’s disease admitted in intensive care unit
Omar Ben Hadj Salem, Sophie Demeret, Alexandre Demoule, Thomas Similowski, Francis Bolgert, Tarek Sharshar, David Grabli
O23 Cerebrospinal fluid glucose and lactate concentrations after subarachnoid hemorrhage
Safa Arib, Ilaria Alice Crippa, Jacques Créteur, Jean-Louis Vincent, Fabio Silvio Taccone
O24 Spontaneous angionegative subarachnoidal hemorrhage: neurological outcome based on a retrospective study of 68 patients
Alexis Soummer, Nicolas Engrand, Pierre Guedin, Grégoire Trebbia, Sorin Aldea, Charles Cerf
O25 Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders
Victoire Desailly, Pierre Pasquier, Patrick Brun, Damien Roux, Jonathan Messika, Gwendoline Latournerie, Laetitia Kasprzyk, Vincent Grosjean, Amine Latreche, Pierre Habert, Stephane Huot, Timon Jobin, Antoine Tesnière, Didier Dreyfuss, Jean-Damien Ricard, Alexandre Mignon, Stéphane Gaudry
O26 Refractory out-of-hospital refractory cardiac arrest treated by veno-arterial extracorporeal membrane oxygenation. A retrospective single-center experience from 2012 to 2015. CARECMO program (Cardiac ARrest Extra Corporeal Membrane Oxygenation)
François-Xavier Laithier, Antoine Kimmoun, Tahar Chouihed, Stéphane Albizzati, Edoardo Camenzind, Fabrice Vanhuyse, Bruno Levy
O27 Decreased monocyte HLA-DR expression after out-of-hospital cardiac arrest
Martin Cour, Fabienne Venet, Romain Hernu, Julie Demaret, Guillaume Monneret, Laurent Argaud
O28 Is emergent PCI associated with a clinical benefit in post-cardiac arrest patients without ST-segment elevation pattern? Insights from the PROCAT II registry
Florence Dumas, Wulfran Bougouin, Guillaume Geri, Lionel Lamhaut, Julien Rosencher, Frédéric Pène, Jean-Daniel Chiche, Olivier Varenne, Pierre Carli, Xavier Jouven, Jean-Paul Mira, Christian Spaulding, Alain Cariou
O29 Predictors of long-term quality of life after cardiac arrest: insights from the Parisian registry
Guillaume Geri, Florence Dumas, Franck Bonnetain,, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Pierre Carli, Eloi Marijon, Olivier Varenne, Jean-Paul Mira, Jean Philippe Empana, Alain Cariou
O30 Red blood cell transfusions in early resuscitation of severe sepsis and septic shock in patients with hematological malignancies
Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, François Vincent, Julien Mayaux, Antoine Rabbat, Martine Nyunga, Anne Pascale Meert, Dominique Benoit, Achille Kouatchet, Michaël Darmon, Fabrice Bruneel, Elie Azoulay, Frédéric Pène
O31 Causal effect of transfusion on mortality and other adverse events among critically ill septic patients: an observational study with a marginal structural model
Claire Dupuis, Michaël Darmon, Carole Schwebel, Elie Azoulay, Romain Sonneville, Lila Bouadma, Roland Smonig, Yves Cohen, Stéphane Ruckly, Christophe Adrie, Dany Goldgran-Toledano, Sébastien Bailly, Guillaume Marcotte, Maïté Garrouste-Orgeas, Jean-François Timsit
O32 Autoimmune hemolytic anemia in the intensive care unit
Antoine Lafarge, Claire Pichereau, Sandrine Valade, Marion Venot, Akli Chermak, Igor Theodose, Marion Scotto, Delphine Kemlin, Claire Givel, Leïla Mourtada, Etienne Ghrenassia, Emmanuel Canet, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay, Eric Mariotte
O33 Pre-ICU location, lead time bias and outcomes in patients with thrombotic microangiopathies
Damien Vimpere, Sandrine Valade, Marion Venot, Claire Pichereau, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Lionel Galicier, Elie Azoulay, Eric Mariotte
O34 Septic shocks with no early etiological diagnosis: a multicenter prospective cohort study (the shock 24 study)
Damien Contou, Damien Roux, Sebastien Jochmans, Remi Coudroy, Emmanuel Guérot, David Grimaldi, Sylvie Ricome, Eric Maury, Gaëtan Plantefève, Julien Mayaux, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost
O35 Respective contribution of diaphragm and limbs muscles weakness on weaning from mechanical ventilation outcome
Alexandre Demoule, Bruno-Pierre Dubé, Julien Mayaux, Julie Delemazure, Thomas Similowski, Martin Dres
O36 Impact of sleep quality on the duration of weaning from mechanical ventilation
Ludivine Rousseau, Xavier Drouot, Véronique Diaz, Yohann Rebollar, Jean-Pierre Frat, Remi Coudroy, René Robert, Arnaud, W Thille, Groupe ALIVE
O37 Integrative ultrasound assessment of lung, cardiac and diaphragm function during a successful weaning trial predicts postextubation distress
Dalinda Ait Aissa, Pierre Coquet, Jean Ruiz, Fabrice Ferre, Lucille Hoarau, Béatrice Riu-Poulenc, Benoit Bataille, Stein Silva
O38 ETCO2 improved outcome prediction of mechanical ventilation weaning
Jean-Luc Baudel, Simon Bourcier, Claire Pichereau, Naïke Bigé, Jalel Tahiri, Vincent Dubée, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
O39 Characteristics of 150 cases of weaning-induced pulmonary oedema and effects of diuretics
Liu Jinglun, Feng Shen, Jean-Louis Teboul, Christian Richard, Xavier Monnet
O40 Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis
Sébastien Bailly, Olivier Leroy, Philippe Montravers, Jean-Michel Constantin, Hervé Dupont, Didier Guillemot, Olivier Lortholary, Jean-Paul Mira, Pierre-François Perrigault, Jean-Pierre Gangneux, Elie Azoulay, Jean-François Timsit
O41 Intensive care acquired pneumonia due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) among patients with prior colonization: Frequency, risk factors and prognosis
Keyvan Razazi, Armand Mekontso-Dessap, Chloe Jansen, Nicolas de Prost, Christian Brun-Buisson
O42 Epidemiology, characteristics and outcomes of septic critically ill patients after the removal of a totally implantable venous-access ports
Marie Lecronier, Valade Sandrine, Naïke Bigé, Nicolas de Prost, Damien Roux, Jean-Damien Ricard, Eric Maury, Julien Mayaux, Elie Azoulay, Alexandre Demoule, Martin Dres
O43 Genetic risk of Pseudomonas aeruginosa ventilator-associated pneumonia: the EXTENSE study
Jean-Paul Mira, Sophie Blein, Nathalie Marin, Christophe Rousseau, Julien Charpentier, Jean-Daniel Chiche, Alexandre Pachot
O44 Cytomegalovirus reactivation enhances the virulence of a Staphylococcus aureus pneumonia in a mouse model
Sami Hraiech, Julien Bordes, Samuel Lehingue, Lamballerie Xavier De, Jean-Louis Mège, Jean-Marie Forel, Christophe Guervilly, Mélanie Adda, Didier Raoult, Laurent Papazian
O45 Families looking back: meaning-making after a decision to accept or refuse organ donation. A qualitative approach
Nancy Kentish-Barnes, Zoé Cohen-Solal, Elie Azoulay
O46 The letter of condolence at the heart of family centered care. A qualitative approach of relatives’ experience
Nancy Kentish-Barnes, Zoé Cohen-Solal, Virginie Souppart, Elie Azoulay
O47 Use of a children information booklet to support young relatives visiting a critically ill adult: impact on ICU practices
Lionel Kerhuel, Carole Haubertin, Isabelle Exbrayat, Elodie Rozières, Audrey Argain, Agnès Suc, Michel Vignes, Pierre Cougot, Béatrice Riu-Poulenc, Stein Silva, Olivier Fourcade, Elodie Brunel
O48 Withdrawal of life-support therapies reporting in ICU randomized controlled trial: Let us move to a transparent reporting—a systematic review
Jonathan Messika, Stéphane Gaudry, Florence Tubach, Emeline Dubief, Blandine Pasquet, Sylvie Guillo, Didier Dreyfuss, Jean-Damien Ricard
O49 Gasp during children end-of-life: healthcare providers’ feelings and knowledge
Charlotte Pierron, Marion Grimaud, Caroline Farnoux, Amélie Maillard
O50 Prognosis of malignant primary brain tumors in intensive care unit
Maxens Decavèle, Nicolas Weiss, Hélène Prodanovic, Julien Mayaux, Ahmed Idbaih, Agusti Alentorn, Jean-Yves Delattre, Thomas Similowski, Alexandre Demoule
O51 Impact of early immunomodulating treatment on outcome of adult patients with anti-N-methyl-d-aspartate receptor encephalitis requiring intensive care: a multicentre study with prospective long-term follow-up
Etienne De Montmollin, Sophie Demeret, Noelle Brule, Marie Conrad, Frédéric Dailler, Nicolas Lerolle, Jean-Christophe Navellou, Carole Schwebel, Mikael Alves, Martin Cour, Nicolas Engrand, Jean-Marie Tonnelier, Stephane Ruckly, Géraldine Picard, Véronique Rogemond, Jean-François Timsit, Jérôme Honnorat, Romain Sonneville, ENCEPHALITICA study group
O52 Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
Chiara Marzorati, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Dominique Benoit, Giuseppe Citerio, Elie Azoulay, Stéphane Legriel
O53 Ammonemia predicts severity and outcome in cirrhotic patients with hepatic encephalopathy in ICU
Simona Tripon, Maxime Mallet, Marika Rudler, Francoise Imbert-Bismut, Dominique Thabut, Nicolas Weiss
O54 Acute varicella zoster encephalitis admitted to the ICU: a case series of 47 patients
Emmanuel Canet, Adrien Mirouse, Romain Sonneville, Laurent Argaud, Stanislas Faguer, Keyvan Razazi, Claude Guérin, Pierre Perez, Anne-Sophie Moreau, Claire Pichereau, François Barbier, Sybille Merceron, Amélie Seguin, Julien Mayaux, Guillaume Geri, Christophe Guitton, Francois Labadie, Elie Azoulay
O55 High-flow nasal cannula for acute respiratory failure in immunocompromised patients
Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Etienne Faucher, Christophe Guitton, Antoine Rabbat, Christophe Girault, Achille Kouatchet, François Vincent, Fabrice Bruneel, Martine Nyunga, Amélie Seguin, Kada Klouche, Sylvie Chevret, Elie Azoulay, Groupe de Recherche en Reanimation Respiratoire du patient d’Onc-hématologie
O56 High-flow oxygen therapy through a nasal cannula in immunocompromised patients with acute hypoxemic respiratory failure
Jean-Pierre Frat, Stéphanie Ragot, Christophe Girault, Remi Coudroy, René Robert, Jean-Michel Constantin, Gwenael Prat, Thierry Boulain, Angéline Jamet,, Alain Mercat, Laurent Brochard, Arnaud, W. Thille
O57 Prospective validations of the PASTEIL score to assess the clinical pretest probability of Pneumocystis jirovecii pneumonia (PjP) in patients with hematologic malignancies (HMs) and acute respiratory failure (ARF)
Elie Azoulay, Sylvie Chevret, Antoine Roux, Etienne Faucher, François Vincent, Antoine Rabbat, Achille Kouatchet, Frédéric Pène, Julien Mayaux, Pierre Perez, Martine Nyunga, Christophe Guitton, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Virginie Lemiale
O58 Bedside contribution of electrical impedance tomography (EIT) to set mechanical ventilation for severe acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO)
Guillaume Franchineau, Nicolas Brechot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
O59 Liberal oxygenation versus restrictive oxygenation in ICU patients: effects on proinflammatory cytokines, sRAGE and organ dysfunctions - results of an ancillary study
Loïc Barrot, Gaël Piton, Michael Bailey, Rakshit Panwar, Nicolas Belin, François Belon,, Cyrille Patry, Jean-Christophe Navellou, Mathilde Grandperrin, Claire Chaignat, Guylaine Labro, Bérengère Vivet, Gilles Capellier
O60 Immature granulocyte level at the acute phase of sepsis, a potential prognostic marker of clinical deterioration. The Septiflux 2 multicenter trial
Thomas Daix, Estelle Guérin, Elsa Tavernier, Emmanuelle Mercier, Valérie Gissot, Christine Vallejo, Jean-Paul Mira, Christophe Guitton, Bruno François, Septiflux trial Group
O61 Analysis of microbiome and resistome using next-generation sequencing in urine samples from patients with sepsis, severe sepsis or septic shock
Céline Ravry, Bruno François, Emmanuelle Begot, Nicolas Pichon, Catherine Chapellas, Anne-Laure Fedou, Antoine Galy, Marie-Cécile Ploy, Olivier Barraud, Philippe Vignon
O62 Patients metabolomic profiles at intensive care admission
Aurelie Thooft, Raphael Conotte, Jean-Marie Colet, Patrick Biston, Michael Piagnerelli
O63 Lymphocyte phenotype during severe sepsis and septic shock
Matthieu Le Dorze, Virginie Tarazona,, Caren Brumpt,, Hélène Moins-Teisserenc,, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
O64 Myeloid-derived suppressor cells expressing arginase-1 and IDO play a major role in immune dysfunction during septic shock
Fabrice Uhel, Imane Azzaoui,, Murielle Gregoire, Céline Pangault, Joëlle Dulong,, Luc Cynober,, Jean-Marc Tadié, Mikaël Roussel,, Yves Le Tulzo, Karin Tarte
O65 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis admitted to the intensive care unit: a multicenter study
Julien Demiselle,, Johann Auchabie,, Julie Boisramé-Helms, Pierre François Dequin, Damien Du Cheyron, Michaël Darmon, Nicolas Chudeau, Guillaume Geri, René Robert, François Fourrier, Steven Grange, Christophe Guitton, Lise Piquilloud, Alexandre Lautrette, Sonia Boyer, Emmanuel Guérot, Julien Letheulle, Nicolas Lerolle
O66 Continuous renal replacement therapy versus intermittent hemodialysis: impact on mortality and renal recovery
Anne Sophie Truche, Michaël Darmon, Sébastien Bailly, Christophe Clec’h, Claire Dupuis, Benoit Misset, Elie Azoulay, Carole Schwebel, Lila Bouadma, Christophe Adrie, Guillaume Marcotte, Philippe Zaoui, Virginie Laurent, Dany Goldgran Toledano, Romain Sonneville, Bertrand Souweine, Jean-François Timsit
O67 Hospital survival and need of renal replacement therapy with respect to AKI duration in critically ill patients: results of a multicenter cohort study
Sophie Perinel Ragey, Anne Sophie Truche, Bertrand Souweine, Sébastien Bailly, Elie Azoulay, Lila Bouadma, Christophe Clec’h, Maïté Garrouste-Orgeas, Antoine Gros, Carole Schwebel, Christophe Adrie, Anne Sylvie Dumenil, Laurent Argaud, Samir Jamali, Dany Goldgran Toledano, Guillaume Marcotte, Michaël Darmon, Jean-François Timsit, For the OUTCOMEREA study group
O68 Early versus delayed initiation of renal replacement therapy in septic acute kidney injury: a retrospective study
Mikhael Chouraqui, Antoine Dewitte, Brigitte Chastel, Pauline Carles, Catherine Fleureau, Olivier Joannes-Boyau, Alexandre Ouattara
O69 Renal recovery after severe acute kidney injury in critically ill myeloma patients
Adrien Joseph, Marion Venot, Sandrine Valade, Eric Mariotte, Claire Pichereau, Akli Chermak, Virginie Lemiale, Elie Azoulay, Emmanuel Canet
O70 Impact of proactive nurse participation in ICU family conferences: a Mixed-Method Study
Maïté Garrouste-Orgeas, Adeline Max, Talia Lerin, Charles Grégoire, Stephane Ruckly, Martin Kloeckner, Cédric Bruel, Sandie Brochon, Francois Philippart, Emmanuelle Pichot, Clara Simons, Jean-François Timsit, Benoit Misset
O71 Duration of platelet storage and outcome of critically ill patients
Andrew Flint, Cécile Aubron, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe Mcquilten
O72 REA-C-SUR safety culture in intensive care in France: is there a link with morbi-mortality conferences?
Cédric Bretonnière, Daniel Villers, Christophe Guitton, Groupe RMM, Qualité et Sécurité des Soins - CBPR-CFAR
O73 Survival of critically ill solid cancer patients: results of a retrospective multicentre study
M Soares, Virginie Lemiale, Djamel Mokart, Frédéric Gonzalez, Fabrice Bruneel, Yves Cohen, Elie Azoulay, Michaël Darmon, François Vincent, for the GrrrOH: Groupe de recherche en réanimation respiratoire en Onco-Hématologie (Group for Research in Respiratory Intensive Care Onco-Hematology)
O74 Encouraging results of the French controlled donation after circulatory death Maastricht category III Program
Clémence Fauché, Michel Muller, Samuel Gay, Olivier Skowron, Albrice Levrat, Didier Dorez
O75 Clinical significance of cardiac troponin I release in severe trauma patients
Maxens Decavèle, Arnaud Foucrier, Sebastian Pease, Tobias Gauss, Catherine Paugam
O76 The modified Glasgow prognostic score is helpful in screening lung cancer patient at risk of hospitalization at the emergency department
Julie Gorham, Lieveke Ameye, Marianne Paesmans, Thierry Berghmans, Jean-Paul Sculier, Anne-Pascale Meert
O77 Relationship between body mass index classes and massive transfusion needs in trauma patients and predictive performance of the TASH score in obese and non-obese populations: a retrospective study on 910 trauma patients
Audrey De Jong, Pauline Deras, Orianne Martinez, Pascal Latry, Samir Jaber, Xavier Capdevila, Jonathan Charbit
O78 The Eschmann stylet as first tracheal access tool during emergency difficult tracheal intubation: An initial simulation trial followed by a clinical study
Jaubert J., Celia Etiennar, Lucie Ginoux, Jean-Luc Sebbah, Hakim Haouache, Gilles Dhonneur
O79 Maternal mortality risk factors for eclampsia
Chaigar Mohammed Cheikh, I. Moussaid, O. Ghazaoui, Kamal Belkadi, S. El Youssoufi, S. Salmi
O80 Use of aminoglycosides in cirrhotic patients admitted in intensive care for severe sepsis or septic shock: short- and intermediate-term impact on renal function and mortality
Laure Pajot, Benjamin Zuber, Carole Schwebel, Romain Sonneville, Benoit Misset, Michael Darmon, Guillaume Marcotte, Anne Sophie Truche, Dany Goldgran-Toledano, Bertrand Souweine, Samir Jamali, Stephane Ruckly, Elie Azoulay, Christophe Clec’h, Jean Pierre Bedos, Jean-François Timsit, OutcomeRéa
O81 Diagnostic yield and therapeutic impact of liver biopsy in the intensive care unit
Bertrand Sauneuf, Benoit Dupont, Axelle Eugène, Jean-Luc Hanouz, Françoise Galateau-Sallé, Nicolas Terzi
O82 Critically ill patients requiring liver transplantation: a 7-year monocentric retrospective experience
Baptiste Michard, Benjamin Lebas, Alexandra Boivin, Max Guillot, Jean-Etienne Herbrecht, Marie-Line Harlay, Ralf Janssen-Langenstein, Maleka Schenck, Bernard Ellero, Marie-Lorraine Woehl-Jaegle, Camille Besch, Vincent Castelain, Philippe Bachellier, Francis Schneider
O83 Hospital survival and access to liver transplantation of MARS-treated patients in France, 2004–2008: a retrospective multicenter study (RETROMARS)
Christophe Camus, Fawzi Saliba, Bernard Goubaux, Agnès Bonadona, Laurence Lavayssiere, Catherine Paugam, Alice Quinart, Olivier Barbot, Sebastien Dharancy, Bertrand Delafosse, Nicolas Pichon, Helene Barraud, Arnaud Galbois, Benoit Veber, Sophie Cayot, Bruno Souche, Clara Locher, RETROMARS Study Group
Olivier Roux, Francesco Figorilli, Antonella Putignano, Pauline Houssel, Claire Francoz, Emmanuel Weiss, Catherine Paugam, Banwari Agarwal, Rajiv Jalan, François Durand
P1 Severe brain injuries: epidemiology and outcome in a Tunisian medical intensive care unit
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P2 Stroke prognosis in the ICU of the regional hospital of Bizerte and withhold and withdrawal treatment decisions
Hatem Ghadhoune, E. Rachedi, J. Guissouma, A. Ben Slimene, W. Azzeza, H. Brahmi, H. Elghord
P3 Brain death predictive factors for traumatic brain injury
Ahmed Youssef Kada, Radia Chikh, Roza Slimani, Kheireddine.a Bouyoucef
P4 Guillain–Barré syndrome in intensive care unit: epidemiology and prognostic factors: analysis of 30 patients
Kais Regaieg, Chtara Kamilia, Najeh Baccouch, Olfa Turki, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir Bouaziz
P5 Eclampsia: epidemiological and clinical study about 194 cases
Fatma Kaaniche Medhioub, Najeh Baccouch, Manel Zekri, Kais Rgieg, Chokri Bhimada, Bouaziz Mounir
P6 Neuroimagery in eclampsia and preclampsia
Chaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, O. Ghazaoui, S. El Youssoufi, S. Salmi
P7 Interest of brain oxygen tension measurement (PbrO2) in the diagnosis of cerebral vasospasm after aneurismal subarachnoid hemorrhage
Elodie Lang, Stephane Welschbillig, Fabian Roy-Gash, Nicolas Engrand
P8 Noninvasive ventilation: an alternative to the intubation during myasthenic crisis
Mathilde Perrin, Fabian Roy-Gash, Stephane Welschbillig, Jean-Michel Devys
P9 Interest of the transcranial Doppler ultrasound in the management of severe traumatic brain injury
Soumia Benbernou, Houria Mokhtari-Djebli, Sofiane Ilies, Khalida Bouyacoub, Abdelkader Azza
P10 VV-ECMO on ARDS: toward a lower anticoagulation ratio?
Elie Zogheib, Joseph Nader, Léonie Villeret, Mathieu Guilbart, Patricia Besserve, Thierry Caus, Hervé Dupont
P11 Inter-hospital transportation of patients implanted with veno-venous ECMO: Experience of the Pitié-Salpêtrière mobile ECMO team
Nicolas Brechot, Ciro Mastroianni, Matthieu Schmidt, Francesca Santi, Guillaume Lebreton, Charles-Edouard Luyt, Jean Louis Trouillet, Ania Nieszkowska, Guillaume Hékimian, Leprince Pascal, Jean Chastre, Alain Combes
P12 Evolution of tidal volume and compliance under pressure-controlled mode during the first 24 hours of ECMO ARDS patients transported to a referral center
Hadrien Roze, Benjamin Repusseau, Jean-Christophe Richard, Virginie Perrier, Alexandre Ouattara
P13 Extracorporeal dioxide carbon removal (ECCO2R), a French national survey
Benjamin Deniau, Jean-Damien Ricard, Jonathan Messika, Didier Dreyfuss, Stéphane Gaudry
P14 Levels of microparticles in acute respiratory distress syndrome with veno-venous extra-corporeal membrane oxygenation
Christophe Guervilly, Fanny Klasen, Sami Hraiech, Jean-Marie Forel, Laurent Papazian
P15 In patients under extracorporeal CO2 removal therapy (ECCO2R) for ARDS can we do prone position? Efficiency, stability and safety of the maneuver
Jean Pierre Ponthus, Polysie Ngasseu, Virginie Amilien, Elise Barsam, Pierre Lehericey, Martial Tchir, Jean Francois Georger
P16 Feasibility of the implementation of a technique of extra-corporeal CO2 removal (ECCO2R) in an intensive care unit which does not use ECMO and its real utilization
Virginie Amilien, Jean Pierre Ponthus, Polysie Ngasseu, Martial Tchir, Elise Barsam, Pierre Lehericey, Jean Francois Georger
P17 Six-hour daily session of high-frequency oscillatory ventilation in moderate-to-severe ARDS: impact on the end-expiratory lung volume, compliance and oxygenation
Bérénice Puech, David Vandroux, Arnaud Roussiaux, Dominique Belcour, Cyril Ferdynus, Olivier Martinet, Julien Jabot
P18 Can we optimize prescription of laboratory tests in surgical intensive care unit (ICU)? Study of appropriateness of care
Marion Fresco, Gaëlle Demeilliers-Pfister, Véronique Merle, Valéry Brunel, Benoit Veber, Bertrand Dureuil
P19 Impact of the implementation of guidelines for laboratory testing in an intensive care unit
Sébastien Leydier, Isabelle Clerc-Urmes, Jérémie Lemarie, Charles-Henri Maigrat, Marie Conrad, Aurélie Cravoisy-Popovic, Damien Barraud, Lionel Nace, Sébastien Gibot, Nelly Agrinier, Pierre-Edouard Bollaert
P20 Identifying useless precaution to reduce costs in ICU
Vincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Guillaume Dumas, Elisabeth Falzone, Patrick Jault, Bernard Lenoir
P21 The ICU of the teaching hospital of Kinshasa
Joseph Nsiala Makunza, Nathalie Mejeni
P22 Security culture and risk management in intensive care units: risk cartography in a French intensive care unit
Amélie Mazaud, Sébastien Béague, Anne-Flore Rousselle, Alain Durocher
P23 Acquiring messages of medical articles according to the reading style: the BIBLIOFLASH multicenter study
Romain Sonneville, Benjamin Sztrymf, Emmanuel Canet, for the BIBLIOFLASH study group
P24 ICU portrayal in social media channels
Pauline Perez, Alexandra Grinea, Nicolas Weiss
P25 The burnout syndrome in a Tunisian intensive care unit: what is the truth?
Hassen Ben Ghezala, Naoures Bedoui, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P26 Resistance of endotracheal tubes measured after extubation in ICU patients
Alina Stoian, Loredana Baboi, Florent Gobert, Hodane Yonis, Romain Tapponier, Jean-Christophe Richard, Claude Guérin
P27 Length of endotracheal tube, humidification system and airway resistance: an experimental bench study
Frédéric Duprez, Arnaud Bruyneel, Thierry Bonus, Grégory Cuvelier, Sharam Machayeckhi, Sandra Olieuz, Alexandre Legrand
P28 Diagnosis contribution and safety of bronchoalveolar lavage in intensive care unit
Fatma Feki, Amira Jamoussi, Takoua Merhebene, Emna Braham, Asma Ghariani, Faouzi El Mezni, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P29 Impact of fiberoptic bronchoscopy performed under noninvasive ventilation on the outcome of critically ill patients: a cohort study over 11 years
Antoine Marchalot, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Steven Grange, Emmanuel Besnier, Gioia Gastaldi, Julien Abily, Marion Beuzelin, Fabienne Tamion
P30 New single-use flexible bronchoscope dedicated for the invasive mechanical ventilation: a proof of concept
Mai-Anh Nay, Adrien Auvet, Julie Mankikian, Virginie Hervé, Antoine Guillon
P31 Incidence of and risk factors for difficult intubation in ICU
Marie Soulie, Pierrick Cronier, Elie Kantor, Laura Federici, Marion Gilbert, Ilham Mezhari, Gérald Choukroun, Sophie Marque
P32 Endotracheal self-extubation in the intensive care unit: a two-year observational study
Z. Coppere, Maxens Decavèle, Jean-Pierre Fulgencio, Clarisse Blayau, Tai Pham, Muriel Fartoukh, Michel Djibre
P33 Criteria to assess extubation readiness and prediction of successful weaning
Matthieu Reffienna, Michel Arnaout, Sébastien Lefort, Anne-Sophie Debue, Fabrice Daviaud, Sarah Cabon, Frédéric Pène, Julien Charpentier, Alain Cariou, Jean-Paul Mira, Jean-Daniel Chiche, Working Group on Mechanical Ventilation
P34 Domestic accidents during school holidays in children
Nabil Tabet Aoul, Zakaria Addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
P35 Pediatric ARDS: interest of prone positioning and NAVA ventilation during veno-venous ECMO
Sylvie Soulier, Philippe Mauriat, Nadir Tafer, Alexandre Ouattara
P36 Esogastric pressure measurement as a guide for noninvasive ventilation in unexplained hypercapnic respiratory failure in infants
Guillaume Mortamet, Alessandro Amaddeo, Sonia Khirani, Brigitte Fauroux
P37 Experience Of Antibacterial Treatment Of Bone And Joint Sepsis Of Young Children
Gennadiy Khanes, Olga Liutko, Svitlana Bidnenko
P38 Comparison of toxic and septic shocks in children
Solenn Remy, Emilie Doye, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne Javouhey
P39 Pediatric carbon monoxide poisoning in the Ile-de-France Region, Link between HbCO level and clinical presentation
Imane El Aouane, Aben Essid, Wallid Hammami, Isabelle Haegy, Jacques Bataille, Jean Bergounioux
P40 Refractory septic shock in children: an ESPNIC definition
Luc Morin, Samiran Ray, Graeme Maclaren, Etienne Javouhey, Simon Nadel, Martin Kneyber, Mark Peters, Koos Jansen, Daniele De Luca, Clare Wilson, Luregn Schlapbach, Pierre Tissières, The infection, inflammation and sepsis section of the ESPNIC
P41 Impact of the Leonetti law on end-of-life practices in a French NICU and PICU, from January 2011 to December 2014
Anne-Claire Girard, Elodie Savajols, Antoine Burguet, Denis Semama, Stephanie Litzler-Renault
P42 Mortality risk factors for anticoagulant-related bleeding
Ines Sedghiani, Hana Fredj, Malek Hassouna, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P43 Management of the polytrauma in the emergency department of CHUOran
Houria Mokhtari-Djebli, Soumia Benbernou, Ahmed Dernane, Fouad Bouakkaz, Khalida Bouyacoub, Abdelkader Azza
P44 Realization of a feedback system of respiratory parameters during CPR
Lhoucine Ben Taleb, Elmaati Essoukaki, A Zeddine Mouhsen, Aissam Lyazidi, Jean-Christophe Marie Richard, Ahmed Mouhsen, Mohammed Harmouchi, Mourad Rattal
P45 Burns from French military operations: a 14-year retrospective observational analysis
Matthias Huck, Thomas Leclerc, Nicolas Donat, Audrey Cirodde, Jean-Vivien Schaal, Yannick Masson, Clément Hoffmann
P46 Drowning in Martinique—characteristics and infectious complications
Dabor Resiere, Laura Cerland, Ruddy Valentino, C Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y Brouste, Bruno Megarbane, Hossein Mehdaoui
P47 Prevalence, characteristics, and associated factors to physician’s conflicts in Emergency Department: A multicentric Moroccan study
Jihane Belayachi, Maha Louriz, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane Abouqal
P48 Serious peripartum complications needing admission in obstetrical ICU: retrospective study about 127 cases
Affra Brahim, Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Khalil Tarmiz, Khaled Benjazia
P49 Epidemiology of suicide in emergency department
Neila Maaroufi, Abid Zeineb, Dhaouadi Mahassen
P50 Beneficial cardiovascular effects of O-GlcNAc stimulation in early phase of septic shock
Julien Cadiet, Marine Ferron, Valentine Prat, Angelique Erraud, Virginie Aillerie, Mathieu Mevel, Amandine Grabherr, John C. Chatham, Chantal Gauthier, Benjamin Lauzier, Bertrand Rozec
P51 MiR-21 deficiency increases mortality during experimental septic shock
Jeremie Joffre, Xavier Loyer, Jean-Rémi Lavillegrand, Lynda Zeboudj, Ludivine Laurans, Bruno Esposito, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
P52 Isolated heart rate reduction by ivabradine does not improve cardiac and vascular function in experimental septic shock
Chaojie Wei, Narimane Al Kattani, Huguette Louis, Sophie Orlowski, Bruno Levy, Antoine Kimmoun
P53 Exploration and modulation of the EGF-R during experimental septic shock
Jean-Rémi Lavillegrand, Lynda Zeboudj, Jeremie Joffre,, Ludivine Laurans,, Bruno Esposito, Alain Tedgui, Pierre-Louis Tharaux, Hafid Ait-Oufella
P54 An intravenous omega-3 bolus at reperfusion time improves shock and vascular dysfunction in a myocardial ischemia–reperfusion rat model
Mélanie Burban, Grégory Meyer, Anne Olland, Blandine Yver, Florence Toti, Valérie Schini-Kerth, Alexandra Monnier, Alexandra Boivin, Pierrick Leborgne, Ferhat Meziani, Julie Boisramé-Helms
P55 Impact of urantide antagonist of urotensinergic system on myocardial function during a murine model of septic shock
Emmanuel Besnier, Thomas Clavier, Mulder Paulus, Hélène Castel, Vincent Richard, Fabienne Tamion
P56 Association of dexamethasone and antibodies to poly-β(1,6)-n-acetyl-glucosamine in prevention and treatment of neonatal bacterial meningitis: an experimental study
Stéphanie Pons, Bruno Mourvillier, David Skurnik
P57 Hyperoxemia as a risk factor for ventilator-associated pneumonia
Sophie Six, Karim Jaffal, Saad Nseir
P59 Significance of prior digestive colonisation with extended-spectrum beta-lactamase producing Enterobacteriaceae in patients with ventilator-associated pneumonia
Rémi Bruyère, Clara Vigneron, Audrey Large, Julien Bador, Serge Aho, Sebastien Prin, Jean-Pierre Quenot, Pierre-Emmanuel Charles
P60 Lower respiratory tract colonization in mechanically ventilated patients: Incidence, risk factors and impact on prognosis
Yosr Touil, Soufia Ayed, Habiba Sik Ali, Najla Tilouch, Houda Mateur, I Talik, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous
P61 Epidemiology of ventilator-associated pneumonia in the ICU among patients already hospitalized: early- versus late-onset pneumonia
Mathilde Grandperrin, Isabelle Patry, Xavier Bertrand, Jean-Christophe Navellou, Gaël Piton, Gilles Capellier
P62 Systematic review of inclusion/exclusion criteria, judgment criteria and statistical hypothesis in randomized controlled trials assessing the efficacy of antimicrobials for hospital-acquired and ventilator-associated pneumonia treatment
Emmanuel Weiss, Jean-Ralph Zahar, Christophe Adrie, Wafa Essaied, Martin Wolkewitz, Jean-François Timsit
P63 Gram stain identification resulting from blindly inserted telescoping plugged catheter material. Does it contribute to diagnosis and treatment of ventilator-associated pneumonia?
Mickaël Soued, Fabrice Cook, David Lobo, Roman Mounier, Aurélie Emirian, Jean Winoc Decousser, Gilles Dhonneur
P64 Colistin in nosocomial pneumonia in intensive care
Hanane Ezzouine, Mohamed Toufik Slaoui, Abdellatif Benslama
P65 Bedside tissue perfusion evaluation predicts intradialytic hemodynamic instability in critically ill patients
Naïke Bigé, Claire Pichereau, Jean-Rémi Lavillegrand, Arnaud Galbois, Mikael Alves, Jean-Luc Baudel, Simon Bourcier, Vincent Dubée, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P66 Evaluation of electrolytes and acid–base disorders in patients undergoing citrate-based anticoagulation for continuous renal replacement therapy in intensive care unit
Benjamin Delmas, Olivier Joannes-Boyau, Antoine Dewitte, Julien Jabot, Dorothée Valance, Nicolas Allou, Jérôme Allyn, Catherine Fleureau,, Alexandre Ouattara
P67 Continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a cost study impact of replacement fluids consumptions
Elodie Jean-Bart, Floriane Bel., Fabienne Morey, Rémi Bruyère, Nicholas Sedillot
P68 Acute kidney injury in patients receiving liposomal amphotericin B in an intensive care unit: register of 104 patients from 2008 to 2014
Marion Venot, Lucie Biard, Sylvie Chevret, Sandrine Valade, Eric Mariotte, Claire Pichereau, Virginie Lemiale, Elie Azoulay, Emmanuel Canet
P69 Regional citrate-based anticoagulation for dummies in continuous venovenous hemofiltration: does it work?
Dorothée Valance, Richard Galliot, Romain Zunarelli, David Vandroux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, Julien Jabot
P70 Incidence of and risk factors for acute kidney injury in early postoperative liver transplantation according to AKIN classification
Jean-Charles Cartier, Thomas Jouve, Marie-Noëlle Hilleret, Rebecca Hamidfar-Roy, Claire Ara-Somohano, Clémence Minet, Agnès Bonadona, Carole Schwebel
P71 Metabolic acidosis uncompensated by kidney in septic patients: a predictive factor for acute kidney injury?
Aline Pourcelet, Jean-Michel Hougardy, Pierre Defrance, Patrick Biston, Michael Piagnerelli
P72 Blood volume monitoring is useful to predict intradialytic hypotension during intermittent hemodialysis
Louis De Laforcade, Alexandre Boyer, Didier Gruson, Benjamin Clouzeau
P73 Risk factors for occurrence of acute kidney injury in diabetic ketoacidosis
Najah Hajjam, Ines Sedghiani, Houda Nasri, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P74 Face-to-face tracheal intubation with the video laryngoscope Airtraq in the sitting patients: a report of 3-year experience in patients after failed conventional tracheal intubation technique
Gilles Dhonneur, Nicolas Mongardon, Eric Levesque, Hakim Haouache
P75 Ultrasound-guided central venous access technique among French intensivists
Marie-Anaïs Bastide, Jack Richecoeur, Eric Frenoy, Christian Lemaire, Bertrand Sauneuf, Fabienne Tamion, Saad Nseir, Damien Du Cheyron, Hervé Dupont, Julien Maizel, BoReal Study Group
P76 Ultrasound-guided venous catheter insertion. What do French intensivists really do?
Hafid Ait-Oufella, Eric Maury, Julien Maizel, Frédérique Schortgen, Cécile Aubron, Christophe Clec’h, Christophe Guitton, Kada Klouche, Nicolas Lerolle, Frédéric Pène, Sebastien Preau, Carole Schwebel, Nicolas Terzi, Frédéric Vargas, Vincent Castelain
P77 Can we trust new connected devices recording heart rate and oxygen saturation? A concordance assessment in intensive care unit
Franck Ehooman, Yacine Tandjaoui-Lambiotte, Claire Montlahuc, Guillaume Van Der Meersch, Johanna Oziel, Jean Bardon, Matthieu Resche-Rigon, Nicolas Postel-Vinay, Yves Cohen
P78 Hemoglobin monitoring with HemoCue©, spectrophotometry and blood cells analyzer: comparison of agreement, completion time and costs
Mehdi Lafi, Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin Sztrymf
P79 Activated partial thromboplastin time and anti-Xa measurements in heparin monitoring among critical care patients
Noémie Tencé, Inès Zaien, Martine Wolf, Pierre Trouiller, Frédéric Jacobs
P80 Agreement between the Point-Of-Care Siemens RAPIDPoint® 500 Blood gas system and central laboratory measurement of hemoglobin, hematocrit, glucose and electrolytes in ICU patients
Jérôme Allardet-Servent, Melissa Lebsir, Christian Dubroca, Mireille Portugal, Matthias Castanier, Thomas Signouret, Guillemette Thomas, Rettinavelou Soundaravelou, Anne Lepidi, Philippe Halfon, Jean-Marie Seghboyan
P81 Clinical features and prognosis of pesticide poisoning
Neila Maaroufi, Dhaouadi Mahassen, Abid Zeineb
P82 Variability of neurobehavioral toxicity of naphyrone, a new synthetic cathinone, according to its acute or binge administration
Camille Gamblin, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno Megarbane
P83 Acute acenocoumarin poisoning: an epidemiological and clinical study
A. M’rad, Hana Fredj, Messaouda Khelfa, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P84 Death by deliberate self-poisoning in Sfax, Tunisia: Victims characteristics and toxic substance profile
Youssef Nouma, Wiem Ben Amar, Sami Bardaa, Karama Regaieg, Kaouthar Jammeli, Mabrouk Bahloul, Zouheir Hammami, Maatoug Samir
P85 Adverse drug reactions (ADRs) collected by medical-staffed ambulances: pilot study
A. Lillo-Le Louët, F. Baud, C. Le Beller, B. Vivien, L. Soufir, P. Carli and H. Le Louët
P86 Prognostic value of plasma concentration of acebutolol in acute poisoning
A. M’rad, Youssef Blel, Fatma Essafi, Nasreddine Foudhaili, Abdelaziz Ben Slimen, Nozha Brahmi, M. Amamou
P87 Baseline pharmacologic treatment for patients admitted in ICU for AECOPD: trends in use and conformity to the GOLD guidelines
Islem Ouanes, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Nesrine Boujelbene, Fahmi Dachraoui, Asma Hachani, Saousen Ben Abdallah, Hend Ben Lakhal, Chaima Ghribi, Imen Ben Ali, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri Abroug
P88 Blood eosinophils levels and acute exacerbations of COPD
Islem Ouanes, Asma Hachani, Lamia Ouanes-Besbes, Saousen Ben Abdallah, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Chaima Ghribi, Fahmi Dachraoui, Fekri Abroug
P89 POFE: postoperative outcomes of chronic obstructive pulmonary disease (COPD) frequent exacerbators after pulmonary resection—a pilot study
Suela Demiri, Christine Lorut, Van Lang, Daniel Luu, Antoine Rabbat, Aurélie Lefebvre, Marco Alifano, Jean-Francois Reignard, Marc Samama, Daniel Dusser, Nicolas Roche
P90 Optimal delivery of salbutamol with a pressurized metered-dose inhaler within a high-flow nasal therapy circuit
François Réminiac, Cassandre Landel, Samuel Gensburger, Thomas Bocar, Lydiane Mordier, Marion Philippe, Déborah Le Pennec, Laurent Vecellio, Stephan Ehrmann
P91 Differences in perceptions between the various healthcare professionals working at the bedside of the risks related to the rehabilitation procedures
Laurent Poiroux, David Thevoz, Julien Simons, Cheryl Hickmann, Jean Roeseler, Anthéa Loiez, Stéphanie Gérard, Nicolas Dousse, Tai Pham, Nicolas Terzi, Lise Piquilloud
P92 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practice
Lorraine Ducroux, Sylvie L’hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent Castelain
P93 Extracorporeal membrane oxygenation for pheochromocytoma-induced cardiogenic shock: report of nine cases
Guillaume Hékimian, Nicolas Brechot, Matthieu Schmidt, Fatima Kharcha, Cécile Ghander, Guillaume Lebreton, Christophe Tresallet, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Charles-Edouard Luyt
P94 Mortality related to cardiogenic shock in critically ill patients in France, 1997–2012
Etienne Puymirat, Jean-Yves Fagon, Philippe Aegerter, Florence Boissier, Jean-Luc Diehl, Caroline Hauw-Berlemont, Bertrand Guidet, Gilles Chatellier, Nicolas Danchin, Nadia Aissaoui
P95 Benefits of extracorporeal life support (ECLS) in elderly patients with postcardiotomy refractory cardiogenic shock
Nadia Aissat, R. Bernard, Guillaume Lebreton, Dimitri Margetis, Julien Amour, Pascal Leprince, Adrien Bouglé
P96 Heart transplantation versus ventricular assist device: which therapy for patients with refractory cardiogenic shock?
Charles Vidal, Guillaume Lebreton, Djavidi Nima, Varnous Shaida, Adrien Bouglé, Pascal Leprince, Julien Amour
P97 Refractory cardiogenic shock in immunocompromised patients rescued by veno-arterial extracorporeal membrane oxygenation
Amandine Dorget, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
P98 Which index severity to use in obstetric medium? (Comparison of 4 scores)
Rabi Toufiki, Youssef Mouaffak, Ahmed Rhassan El Adib, M. Amine
P99 Maternal mortality in obstetric department of UH IBN ROCHD, Casablanca, Morocco
Kamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. Moumine, S. El Youssoufi, S. Salmi
P100 Disseminated intravascular coagulation in pregnant women: evaluation of a new score
Marie Jonard, Anne Sophie Ducloy-Bouthors, François Fourrier
P101 Validity of severity scores in critically ill obstetric patients
Fatma Kaaniche Medhioub, Anis Chaari, Olfa Turki, Kais Rgieg, Mabrouk Bahloul, Hmida Chokri Ben, Bouaziz Mounir
P102 Evaluation of a neuromuscular blockade with benzylisoquinoliniums: a comparison of a train of four with a clinical assessment
Pierre Bouju, Nicolas Barbarot, Arnaud Gacouin, Fabrice Uhel, Julien Letheulle, Pierre Fillatre, Guillaume Grillet, Angélique Goepp, Jean-Marc Tadié, Yves Le Tulzo
P103 The use of enteral route for drug administration in the ICU is dimly rational
Anne-Laure Clairet, Gilles Capellier, Samuel Limat, Christian Cornette, Gaël Piton
P104 Microcirculatory effects of norepinephrine in septic shock: a muscle microdialysis study
Amira Fatnassi, Zied Hajjej, Chiheb Romdhani, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P105 Administration of drugs per os by stomach tube for enteral feeding in surgical ICU
Hind Taibi, Ijlal Elatiqi, A Iraqui, Rachid Cherkab, Wafae Haddad, Chafik Elkettani, Lahoucine Barrou
P106 Implementation of an intensive care follow-up clinic
Fabien Cave, Alain Mercat, Nicolas Lerolle
P107 Needs assessment of adults post-intensive care rehabilitation department in Amiens University Hospital
Gaelle Bacari-Risal, Pierre Louis Doutrellot, Benoit Vaysse, M. Inan, K. Khelfoun, M. Nasserallah, Julien Maizel, C. Legrand-Monteil, S. Tasseel-Ponche
P108 Factors of degradation on independence and quality of life at 3 and 6 months after stay in intensive care unit
Benjamin Kowalski, Anne Guaguere, Claire Boulle-Geronimi
P109 Octavie: Epidemiological study of mortality and autonomy 3 and 6 months after ICU stay for very elderly patients
Juliette Masse, Clément Vanbaelinghem, Patrick Herbecq
P110 Analysis of burn injuries in the elderly
Amel Mokline, Syrine Draief, Lazhari Gharsallah, Imen Rahmani, Bahija Gasri, Sofiene Tlaili, Rym Hammouda, Amen Allah Messadi
P111 ICU admission criteria for patients 85 years and older
Philippe Michel, Bruno Gelée, Fouad Fadel, Marie Thuong
P112 Facteurs pronostiques chez les patients âgés admis en réanimation médicale. Prognostic factors in elderly patients admitted in medical intensive care
Sandra Ait-Aoudia, Salima Laddi, Mohamed-Mohcen Sahraoui
P113 Uncontrolled donation after circulatory determination of death: 42 months of experience in a general hospital
Clémence Fauché, Samuel Gay, Michel Muller, Anna Faucher, Olivier Skowron, Albrice Levrat, Didier Dorez
P114 Epidemiology of long stays in ICU
Bertrand Hermann, Caroline Hauw Berlemont, Alexandra Monnier, Florence Boissier, Nadia Aissaoui, Jean-Yves Fagon, Jean-Luc Diehl, Emmanuel Guérot
P115 Are daily sedation stops safe in a medical ICU?
Michel Arnaout, Julien Charpentier, Benoit Champigneulle, Julie Busson, Anne-Sophie Debue, Julie Dhumeaux, Guillaume Geri, Wulfran Bougouin, Nicole Ericher, Sébastien Lefort, Pierre Lucas, Alain Cariou, Jean-Paul Mira, Frédéric Pène, Jean-Daniel Chiche, Groupe de travail sur la ventilation
P116 Delay in awakening after stopping continuous sedation in critically ill patients: incidence, risk factors and impact on ventilator weaning
Magalie Dumas, Celine Chapelle, Benedicte Philippon-Jouve, Jerome Morel, Pascal Beuret
P117 Risk factors and prognosis impact of decreased patient–ventilator synchrony in mechanically ventilated patients—a prospective study
Côme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6—Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, Paris
P118 High-flow oxygen therapy through a nasal cannula versus noninvasive ventilation versus in immunocompromised patients with acute respiratory failure
Remi Coudroy, Angéline Jamet, Philippe Petua, René Robert, Jean-Pierre Frat, Arnaud, W. Thille
P119 The use of dexmedetomidine in patients with noninvasive ventilation: a preliminary study
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P120 Comparison of tolerance of 4 interfaces for preventive noninvasive ventilation after abdominal surgery in intensive care units assessed by patients and caregivers
Audrey De Jong, Albert Prades, Marion Monnin, Martin Mahul, Marion Basty, Clément Monet, Benjamin Mounet, Emmanuel Futier, Gérald Chanques, Samir Jaber
P121 Dexmedetomidine, new approach in sedation analgesia: a prospective and observational study of mechanically ventilated patients in adults intensive care units in a university hospital during the first year of use
Audrey Leroux, Xavier Oudinot, Gaëlle Demeilliers-Pfister, Marc Laurent
P122 Pain, confusion, and agitation associated with noninvasive ventilation
Nesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Saousen Ben Abdallah, Mahdi Marzouk, Asma Hachani, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Chaima Ghribi, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri Abroug
P123 Impact of metformin on prognosis of ICU patients
Sebastien Jochmans, Jean-Emmanuel Alphonsine, Ly Van Vong, Nathalie Rolin, Oumar Sy, Jean Serbource-Goguel, Jonathan Chelly, Olivier Ellrodt, Mehran Monchi, Christophe Vinsonneau
P124 Serum cholinesterase activity in the diagnosis of septic shock due to bacterial infections: a new specific biomarker of sepsis
Mabrouk Bahloul, Turki Olfa, Najeh Baccouche, Kais Regaieg, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir Bouaziz
P125 Is hyperoxaemia a rare event during septic shock patients management?
Amélie Trichot, Gwenhaël Colin, Jean-Baptiste Lascarrou, Isabelle Vinatier, Konstantinos Bachoumas, Jean-Claude Lacherade, Maud Fiancette, Aurélie Joret, Aihem Yehia, Christine Lebert, Matthieu Henry-Laguarrigue, Laurent Martin-Lefèvre
P126 Myocardial depressant factor during human septic shock: screening of twenty-three cytokines and chemokines
Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Nicolas de Prost, Aurelien Seemann, Christian Brun-Buisson, Sophie Hüe, Armand Mekontso-Dessap
P127 Plasma of septic shock patients modifies in vitro mitochondrial respiration of human PBMC as well as lymphocytes and monocytes cell lines
Raphaël Clere-Jehl, Julie Boisramé-Helms, Anne-Laure Charles, Pierrick Leborgne, Xavier Delabranche, Bernard Geny, Ferhat Meziani, Pascal Bilbault
P128 Assessment of skin endothelial functions during severe infections
Simon Bourcier, Claire Pichereau, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jalel Tahiri, Naïke Bigé, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P129 Toe-to-Room temperature gradient correlates with tissue perfusion and predicts outcome during septic shock
Simon Bourcier, Claire Pichereau, Pierre Yves Boêlle, Nemlaghi Safaa, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jean-Rémi Lavillegrand, Naïke Bigé, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P130 Determination of HLA-DR expression on monocytes in heart recipients and clinical outcome correlation
Sylvie Paulus, Claire Flamens, Guillaume Monneret, Julie Demaret, Jean Neidecker
P131 Nosocomial infections in neonates under ECMO
Jerome Rambaud, Cecile Allioux, Romain Guedj, Isabelle Guellec, Julia Guilbert, Pierre-Louis Leger, Maryne Demoulin, Amélie Durandy, Sandrine Jean, Ricardo Carbajal
P132 Point-of-care ultrasound in pediatric and neonatal intensive care units: prospective, observational transversal study
Aurélie Morand, Laurent Zieleskiewicz, Olivier Brissaud, Stéphane Le Bel, Mickael Afanetti, Zoé Meresse, Astrid Botte, Michel Panuel, Laurent Thomachot, Jean-Michel Constantin, Marc Leone, Fabrice Michel
P133 Use of continuous infusion of clonidine for sedation in critically ill children: indications, efficacy and side effects
Anna Deho’, Laïly Sadozai, Stéphane Dauger, Sonia Prot-Labarthe
P134 Pharmacokinetic analysis of continuous infusion vancomycin therapy in critically ill children
Mathieu Genuini, Mehdi Oualha, Moulin Florence, Jean-Marc Treluyer, Fabrice Lesage, Sylvain Renolleau
P135 Incidence of central venous catheter-associated bacteraemia in a paediatric intensive care unit
Emmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane LeteurtreEmmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane Leteurtre
P136 Outcome at 2 months at the infectious level of the pediatric central venous catheters: prospective evaluation of the guidelines optimization impact
Marie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe DesprezMarie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe Desprez
P137 Ten years of intensive care in children hospital in Oran, Algeria
Nabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenNabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
P138 High-frequency percussive ventilation during neonatal transportation: a pilot study
Benoît Colomb, Karine Kolev-Descamp, Anne Marie Petion, Laurent Queudet, Elodie Savajols, Stephanie Litzler-Renault, Denis Semama
P139 Lymphopenia after severe infectious shock in children: association with severity and risk for nosocomial infection
Emilie Doye, Solenn Remy, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne Javouhey
P140 Importance of troponin evaluation in scorpion envenomation in pediatric intensive care unit
Mouaffak Youssef
P141 Hyperosmolar therapy in pediatric traumatic brain injury: a retrospective study
Nadia Roumeliotis, Christian Dong, Geraldine Pettersen, Louis Crevier, Guillaume Emeriaud
P142 Cerebral sinovenous thrombosis in children: report of seven cases
Mouaffak Youssef
P143 Optimising nurse confidence and skill acquisition in paediatric continuous renal replacement therapy (pCRRT) through a training programme: result of the first-year experience in a tertiary care centre
Jérôme Naudin, Laetitia Abdallah, Marion Ganier, Karine Frannais, Dylia Douglas, Cecile Flusin, Anna Deho’, Stéphane Dauger
P144 From high-quality electronic database to the new concept of perpetual patient. Preliminary results
David Brossier, Redha Eltaani, Michaël Sauthier, Guillaume Emeriaud, Bernard Guillois, Philippe Jouvet
P145 Transportation of children on extracorporeal membrane oxygenation: 1-year experience of a tertiary referral center in the Paris regionJerome Rambaud, Pierre-Louis Leger, Michelle Larroquet, Alain Amblard, Noella Lode, Julia Guilbert, Sandrine Jean, Isabelle Guellec, Isabelle Casadevall, Katia Kessous, Hervé Walti, Ricardo Carbajal
P146 Acute neurotoxicity of bath salts combining 3,4-methylenedioxypyrovalerone and mephedrone in the rat
Christophe Poiré, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Huixiong Chen, Bruno Megarbane
P147 Acute organophosphate poisoning: what about pralidoxime use?
A. M’rad, Sahar Habacha, Bassem Chatbri, Youssef Blel, H Thabet, Nozha Brahmi, M. Amamou
P148 Acute nifedipine poisoning: clinical and prognosis aspects
A. M’rad, Fatma Essafi, Nasreddine Foudhaili, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P149 Acute behavioral toxicity and addictive liability of the new synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in the rat
Cyril Masniere, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno Megarbane
P150 Clinical and therapeutic characteristics of metformin poisoningA. M’rad, Messaouda Khelfa, Hana Fredj, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P151 Calcium channel blockers poisoning
Samar Souissi, Hatem El Ghord, N. Kouraichi, N. Brahmi, H. Thabet, M. Amamou
P152 Characteristics and outcomes in patients with community-acquired pneumonia admitted to intensive care unit
Takoua Marhbène, Islam Mejri, Amira Jamoussi, Douha Lakhdar, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P153 Comparison of characteristics and outcomes of pneumococcal community-acquired pneumonia versus other pathogens
Takoua T. Merhabane, Héla Maamouri, Amira Jamoussi, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P154 Outcome of L. pneumophila pneumonia and risk factors for ICU admission
Oestreicher Charlotte, Helena Wegelius, Caroline Landelle, Jacques Schrenzel, Laurent Kaiser, Jérôme Pugin
P155 The descending necrotizing mediastinitis: report of 60 cases
Hind Belhadj
P156 Characteristics, mortality risk factors and therapeutic approach of ARDS in patients with severe leptospirosis in Reunion Island
Paul Chanareille, Julien Jabot, Benjamin Delmas, Arnaud Roussiaux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David Vandroux
P157 Characterization of organ dysfunction in severe leptospirosis
Adélie Ladureau, Alice Sanna, Amélie Rolle, Bertrand Pons, Pascale Piednoir, Fanny Ardisson, Frédéric Martino, Thomas Bernos, Khalid Elkoun, Elie Elain, Roland Lawson, Matthieu Resh-Rigon, Sophie Belorgey, Guillaume Thiery
P158 Report of experience: management of a pre-XDR and XDR-TB population hospitalized in a medical ICU
Caroline Hauw Berlemont, Cyprian Pricopi, Florence Boissier, Alexandra Monnier, Françoise Barthes, Jean-Luc Diehl, Jean-Yves Fagon, Emmanuel Guérot
P159 Benefit of magnesium sulfate for tetanus management in adults: case of the provincial general referral hospital of Kinshasa
Thansya Doddie, Mj Nsiala, Nh Situakibanza, Be Amisi, Mj Kazadi, Ma Kilembe
P160 Ebola fever outbreak: questioning the delivery of care
Christophe Clement, François Lamontagne
P161 Marked decrease in the incidence of ventilator-associated pneumonia using a bundle of care containing selective oropharyngeal decontamination
Boyer, Valérie Nocquet, Caroline Landelle, Sébastien Naimo, Ronan Raulais, Emilie Genevois, Lucie Bouchoud, Filippo Boroli, Nour Abidi, Mohamed Abbas, Stefan Harbarth, Jérôme Pugin
P162 Ventilator-associated pneumonia prevention by oral care improvement: a before–after study
Pierre-Emmanuel Charles, Caroline Dereux, Audrey Large, Rémi Bruyère, Sebastien Prin, Julien Bador, Jean-Pierre Quenot
P163 Impact of a multifaceted bundle ventilator-associated pneumonia prevention program in a secondary care medical–surgical intensive care unit
Stanislas De Guillebon, Eloise Morisse, Julie France, Deborah Gasser, Philippe Badia, Walter Picard
P164 Daily chlorhexidine bathing in a medical intensive care unit: effects on healthcare-associated infections and on acquisition of multidrug-resistant bacteria
P. Corne, Nicolas Molinari, I. De Boulastel, S. Seguin, A. Blasco, V. Ledur, Olivier Jonquet, Kada Klouche
P165 Impact of twin bedrooms intensive care unit on the epidemiology of extended-spectrum beta-lactamase-producing enterobacteriaceae
Paktoris-Papine Sophie, Margaux Artiguenave, Faten El Sayed, Florence Espinasse, Aurélien Dinh, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron
P166 Prophylactic confinement after liver transplant: a necessity or a useless precaution?
Benjamin Lebas, Sophie Hatsch, Quentin Maestraggi, Anne-Florence Dureau, Vincent Castelain, Bernard Ellero, François Faitot, Max Guillot, Francis Schneider
P167 Proteomic response and adaptation mechanisms of E. coli 536 to overcome the inhibitory effect of cranberry proanthocyanidins
Dimitri Margetis, Odile Bouvet, Didier Chevret, Didier Dreyfuss, Erick Denamur, Jean-Damien Ricard
P168 Is daily measurement of CRP useful to detect earlier ventilator-associated pneumonia?
Justine Simonet, Mathieu Boutonnet, Jean-Louis Daban, Elisabeth Falzone, Guillaume Dumas, Philippe Vest, Vincent Peigne
P169 Clinical and biological features of healthcare-associated coagulase-negative Staphylococci meningitis: results of a retrospective study
Severine Couffin, David Lobo, Gilles Dhonneur, Roman Mounier
P170 Prognostic value of electrocardiographic abnormalities in patients with acute pulmonary embolism
M. Cheikh Bouhlel, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y. Hamdaoui, Jihene Ayachi, W. Brahim, Rania Bouneb, Mohamed Boussarsar
P171 Does mean arterial pressure alarm improve the time spent within blood pressure target range in septic shock? A before and after study
Nans Florens, Martin Cour, Julie Varéon, Arnaud Malatray, Romain Hernu, Laurent Argaud
P172 Respiratory change of pulse pressure is not indicative of preload reserve in cardiac surgery patients
Pierre Dupland, Thomas D’humières, Romain Vergier, Pauline Issaurat, Philippe Estagnasié, Pierre Squara, Alain Brusset
P173 Importance of diastolic arterial pressure to optimize pulse pressure variation performances for patients receiving norepinephrine
Vincent Génin, David Vandroux, Cyril Ferdynus, Arnaud Roussiaux, Jérôme Allyn, Nicolas Allou, Olivier Martinet, Julien Jabot
P174 Multi-parameter monitoring for tissue perfusion in septic shock: correlations between macrohemodynamic and metabolic parameters: Preliminary results
Ali Jendoubi, Rifka Jlassi, Bassem Hamrouni, Yahia Marzougui, Jihen Kouka, Salma Ghedira, Mohamed Houissa
P175 Correlation between changes in levels of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and weight before and after dialysis
Kaouther Dhifaoui, Zied Hajjej, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P176 Impact of colonization with multidrug-resistant bacteria on the outcome of patients with hematological malignancies admitted to the intensive care medicine
Johanna Oziel, Carole Schwebel, Elie Azoulay, Michaël Darmon, Bertrand Souweine, Lila Bouadma, Guillaume Marcotte, Christophe Clec’h, Yves Cohen, Outcomerea Study Group
P177 ICU moving followed by a drop of imipenem-resistant Pseudomonas aeruginosa
Alexy Tran Dinh, Caroline Neulier, Marlène Amara, Nicaise Nebot, Gilles Troché, Nelly Breton, Benjamin Zuber, Sébastien Cavelot, Béatrice Pangon, Jean Pierre Bedos, Jacques Merrer, David Grimaldi
P178 Risk factors of carbapenem resistance acquisition in intensive care unit
François Labaste, Jean-Marie Conil, Julia Grossac, Stéphanie Ruiz, Marion Grare, Olivier Fourcade, Vincent Minville, Bernard Georges
P179 Risk factors for subsequent infection among patients with extended-spectrum beta-lactamase-producing enterobacteriaceae colonization: a retrospective study
Guillaume Van Der Meersch, Johanna Oziel, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Philippe Karoubi, Christophe Huang, Christophe Clec’h, Yves Cohen
P180 Is rectal colonisation predictive of extended-spectrum β-lactamase-producing enterobacteriaceae presence in respiratory samples performed in the intensive care unit?
Helene Carbonne, Matthieu Le Dorze, Rishma Amarsy, Joaquim Mateo, Didier Payen de la Garanderie
P181 Antibiotic therapy in intensive care unit patients: appraisal of medical attitude related to therapy appropriateness, severity of infection and outcome
Sophie Leloup Von Edelsberg, Christelle Vercheval, Monique Nys, Pierre Damas
P182 Epidemiology and associated factors of ICU-acquired infections in critically ill patients: a prospective cohort study
Zied Hajjej, Chaker Bouguerra, Noura Naas, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P183 The impact of nosocomial infection acquired in intensive care units on mortality and length of stay until hospital discharge: a retrospective, monocentric, 10-year study
Joris Muller, François Severac, Mickael Schaeffer, Pierre Tran Ba Loc, Stéphanie Deboscker, Maleka Schenck, Marie-Line Harley, Ralf Janssen-Langenstein, Jean-Etienne Herbrecht, Benjamin Lebas, Max Guillot, Vincent Castelain, Francis Schneider, Thierry Lavigne
P184 Incidence and prognosis of catheter-associated urinary tract infections in intensive care unit: the IPRIUS study
Jennifer Brunet, Bertrand Canoville, Cédric Daubin, Amélie Seguin, Nicolas Terzi, Xavier Valette, Pierre Verrier, Damien Du Cheyron
P185 Automatic tube compensation during mechanical ventilation in ICU patients. Meta-analysis of trials on weaning outcome and physiologic effects
Alina Stoian, Claude Guérin
P186 Automated oxygen titration during high-flow oxygen therapy. Evaluation of the feasibility in healthy subjects
François Lellouche, Erwan L’her, Pierre Alexandre Bouchard, Mathieu Delorme, Tamer Elfaramawy, Benoit Gosselin
P187 Accuracy of ventilators for intermediate care to deliver tidal volume. A bench study
Claude Guérin, Loredana Baboi, Sarah Guegan, Fabien Subtil
P188 Efficiency of ventilators for intermediate care to deliver adequate FIO2. A bench study
Claude Guérin, Loredana Baboi, Fabien Subtil, Sarah Guegan
P189 In vitro comparison of inspiratory-synchronized and continuous nebulization modes during noninvasive ventilation: analysis of inhaled and lost doses
Jean-Bernard Michotte, Enrico Staderini, Jonathan Dugernier, Rares Rusu, Jean Roeseler, Giuseppe Liistro, Gregory Reychler
P190 Short-term physiological effects of nasal high flow in patients with respiratory distress. Impact of flow rates on the work of breathing
Mathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François Lellouche
P191 Design and implementation of an active artificial lung
Elmaati Essoukaki, Lhoucine Ben Taleb, Mohammed Harmouchi, Mourad Rattal, Ahmed Mouhsen, Jean-Christophe Marie Richard, A Zeddine Mouhsen, Aissam Lyazidi
P192 Assessment of the accuracy of ventilator simulation softwares
Frédéric Duprez, Jean Bernard Michotte, Olivier Contal, Thierry Bonus, Sandra Olieuz, Grégory Cuvelier, Sharam Machayeckhi
P193 Outcome and early prognostic factors in neutropenic patients admitted to the intensive care unit
Becem Trabelsi, Zied Hajjej, Walid Sammoud, Hedi Garsallah, Mustapha Ferjani
P194 Blood loss and transfusion practice in medical surgical intensive care unit: 1-year study
Walid Sammoud, Zied Hajjej, Khaoula Harira, Hedi Garsallah, Mustapha Ferjani
P195 Atypical hemolytic and uremic syndrome in critically ill adult patients
Elie Azoulay, Akli Chermak, Cédric Rafat, Claire Pichereau, Emmanuel Canet, Virginie Lemiale, Valade Sandrine, Marion Venot, Benoît Schlemmer, Eric Mariotte
P196 Outcome of critically ill patients after allogeneic hematopoietic stem cell transplantation: comparison of cord blood cells with others cells as hematopoietic stem cells source
Caroline Le Jeune, Florent Wallet, Pascal Roy, Laurent Argaud, Mauricette Michallet
P197 Outcome of patients with organ failures related to solid malignancies and receiving chemotherapy in the intensive care unit
Yoann Zerbib, Julien Maizel, Naïke Bigé, Benoit Misset, Nicolas de Prost, Virginie Lemiale, Sylvie Ricome, François Baudin, Muriel Fartoukh, Frédéric Jacobs, François Blot, Matthieu Schmidt, Antoine Rabbat, Julien Mayaux, Frédéric Gonzalez, Caroline Bornstain, Elie Azoulay, Frédéric Pène
P198 Characteristics and outcomes of patients with hematological malignancies (HMs) admitted to the intensive care unit
Stéphanie Gelinotte, Dorothée Carpentier, Steven Grange, Julien Abily, Marion Beuzelin, Emmanuel Besnier, Gioia Gastaldi, Gaetan Beduneau, Jean-Philippe Rigaud, Christophe Girault, Fabienne Tamion
P199 Influence of neutropenia on mortality of critically ill cancer patients: Results of a systematic review and meta-analysis of available evidences
Marie Bouteloup, Sophie Perinel Ragey, Elie Azoulay, Djamel Mokart, Michaël Darmon, Groupe de Recherche en Réanimation Respiratoire et Onco-Hematologique (GRRROH)
P200 Thrombotic Microangiopathy (TMA) Syndromes in the ICU: experience of a Tunisian ICU
Jihene Ayachi, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y Hamdaoui, H. Nouira, Rania Bouneb, Mohamed Boussarsar
P201 “Immunonutrition” failed to improve septic shock-induced vascular dysfunction in a rat model
Julie Boisramé-Helms, Grégory Meyer, Su Degirmenci, Mélanie Burban, Valérie Schini-Kerth, Alexandra Boivin, Raphaël Clere-Jehl, Alexandra Monnier, Christine Kummerlen, Ferhat Meziani
P202 PTP1B gene deletion improves glucose metabolism and limits cardiovascular dysfunction in experimental septic shock
Eugénie Delile, Pierre-Alain Thiébaut, Jean-Claude Do Rego, David Coquerel, Rémi Nevière, Vincent Richard, Fabienne Tamion
P203 Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis
Laure Ichou, Nicolas Carbonell, Pierre-Emmanuel Rautou, Ludivine Laurans, Simon Bourcier, Claire Pichereau, Jean-Luc Baudel, Jean-Baptiste Nousbaum, Christophe Renou, Rodolphe Anty, Jacques Tankovic, Eric Maury, Bertrand Guidet, Luce Landraud, Hafid Ait-Oufella
P204 Modulation of inflammatory response related to severe peritonitis by polymyxin-B hemoperfusion
Remi Coudroy, Jean-Claude Lecron, Didier Payen de la Garanderie, René Robert, ABDOMIX Group
P205 Descriptive study of ultrasonographic data inside a surgical intensive care unit for cholestasis diagnosis: dechorea study
Michael Helary, Jonathan Paillot, Sebastien Pili-Floury
P206 In-hospital mortality and predictive risk factors for patients with cirrhosis
Sana Khedher, Amira Maoui, Asma Ezzamouri, Mohamed Salem
P207 CONSTIPREA: evaluation of the management of constipation in intensive care—National Survey of French intensivits
Lamia Kerdjana, Mihaela Dumitrescu, Olivier Mimoz, Bertrand Debaene, Virginie Migeot, Claire Dahyot-Fizelier
P208 Corrosive ingestion in adults: endoscopic findings and agents involved
Sana Khedher, Asma Ezzamouri, Amira Maoui, Mohamed Salem, Amira A. Maoui
P209 Hypoxic hepatitis after out-of-hospital cardiac arrest: incidence, determinants and prognosis
Benoit Champigneulle, Guillaume Geri, Wulfran Bougouin, Florence Dumas, Michel Arnaout, Lara Zafrani, Frédéric Pène, Julien Charpentier, Jean-Paul Mira, Alain Cariou
P210 Aspiration pneumonitis in comatose patients treated with invasive mechanical ventilation. The SPIRE prospective survey
Jean-Baptiste Lascarrou, Floriane Lissonde, Aurélie Le Thuaut, Konstantinos Bachoumas, Gwenhaël Colin, Matthieu Henry-Laguarrigue, Maud Fiancette, Jean-Claude Lacherade, Christine Lebert, Isabelle Vinatier, Aihem Yehia, Aurélie Joret, Laurent Martin-Lefèvre, Jean Reignier
P211 Ventilator-associated pneumonia (VAP) in cancer patients: impact of 1-year survival
Laura Platon, Jerôme Lambert, David Lagier, Jeanpaul Brun, Antoine Sannini, Laurent Chow-Chine, Magali Bisbal, Marion Faucher, Djamel Mokart
P212 High-resolution computed tomography (HRCT) patterns in patients with pneumocystis pneumonia
Leïla Mourtada, Lemiale Virgnie, Claire Givel, Valade Sandrine, Claire Pichereau, Emmanuel Canet, Eric Mariotte, Elie Azoulay
P213 Plasma endocan predicts the occurrence of acute respiratory distress syndrome (ARDS) in severe sepsis and septic shock patients
Alexandre Gaudet, Erika Parmentier-Decrucq, Nathalie De Freitas Caires, Sylvain Dubucquoi, Philippe Lassalle, Daniel Mathieu
P214 Comparison of 3 diagnostic methods to identify fluid responsiveness during prone position in ARDS
Jean-Christophe Richard, Hodane Yonis, Florent Gobert, Romain Tapponnier, Claude Guérin
P215 Low pressure support-high PEEP for early severe acute respiratory distress syndrome: a retrospective analysis
Luc Quintin, C. Pichot, F. Petitjeans
P216 Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence
Antoine Guillon, Youenn Jouan, Daborah Breah, Fabien Gueugnon, Emilie Dalloneau, Thomas Baranek, Clemence Henry, Eric Morello, Jc Renauld, M Pichavant, Philippe Gosset, Y Courty, Patrice Diot, Mustapha Si-Tahar
P217 Impaired phagocytosis of apoptotic neutrophils in human ARDS: beneficial effects of metformin
Fabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Yves Le Tulzo, Karin Tarte, Jean-Marc Tadié
P218 What are the deteP219 Emergency thoracotomy: development and results in a military trauma centerrminants of needle aspiration success in primary spontaneous pneumothorax?
Constance Vuillard, Jean-Damien Ricard, Béatrice La Combe, Stéphane Gaudry, Didier Dreyfuss, Jonathan Messika
P219 Emergency thoracotomy: development and results in a military trauma center
Pauline Ponsin, Jean-Louis Daban, Guillaume Boddaert, Bertrand Grand, Vincent Peigne, Yohan Baudoin, Mathieu Boutonnet, Patrick Jault, Stéphane Bonnet
P220 Management of isthmic aortic rupture in polytraumatized patients in ICU: a report of 12 cases
Chtara Kamilia, Kais Regaieg, Olfa Turki, Najeh Baccouch, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir Bouaziz
P221 NT-proBNP levels and echocardiography findings in the etiologic diagnosis of acute dyspnea
Salah Snouda, Hassen Ben Ghezala, Mohamed Fehmi Abbes, Rebeh Daoudi, Moez Kaddour, Imen Benchiekh
P222 Cardiac decompensation in peripartum
Kamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. El Youssoufi, S. Salmi
P223 Peripheral intravenous catheter-related complications in an emergency ward
Ines Sedghiani, Hana Fredj, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P224 Burnout in the emergency room
Neila Maaroufi, Abid Zeineb
P225 Prevalence, and characteristics of elderly patient admitted in a Moroccan Medical Unit for the Acute Care
Jihane Belayachi, Leila Debono, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane Abouqal
P226 Metabolic phenotyping in bronchoalveolar lavage fluids distinguishes influenza and pneumococcal pneumonia
Adrien Auvet, Antoine Guillon, Lydie Nadal-Desbarats, Thomas Baranek, Eric Morello, François Réminiac, Mustapha Si-Tahar
P227 Microbiological documentation of pneumonia in the ICU by per-bronchoscopic bronchial aspiration (PBA) is very similar to that obtained by bronchoalveolar lavage (BAL)
Jean-Luc Baudel, Jacques Tankovic, Redouane Dahoumane, Arnaud Galbois, Hafid Ait Oufella, Georges Offenstadt, Eric Maury, Bertrand Guidet
P228 Compliance with the H3 bundle of the 2012 surviving sepsis campaign according to the chain of care of septic patients: the sepsis CHOC study
Amel Filali, Emmanuel Faure, Nicolas Van Grunderbeeck, Olivier Nigeon, Juliette Masse, H Bazus, Jihad Mallat, Didier Thevenin
P229 CRP ratio as a predictive tool for mortality in ICU septic patients
Sophie Lempereur-Legros, Didier Ledoux, Monique Nys, Pierre Damas
P230 Candidemia in ICU: Epidemiology and prognostic factors
Zied Hajjej, Walid Sammoud, Becem Trabelsi, Iheb Labbene, Mustapha Ferjani
P231 Extracorporeal membrane oxygenation cannula-associated infections: implication of virulent Escherichia coli phylogroups
Jonathan Messika, Olivier Clermont, Matthieu Schmidt, Alexandra Aubry, Romain Fernandes, Erick Denamur, Alain Combes, Jean-Damien Ricard
P232 Is diabetes mellitus a risk factor for intensive care unit-acquired infections in intensive care unit patients with hematologic malignancies?
Marion Venot, Sylvie Chevret, Djamel Mokart, Frédéric Pène, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Elie Azoulay
P233 Should we need aerobic–anaerobic or specific blood culture bottles for diagnosing candidemia in ICU patients?
Sébastien Bailly, Jean-François Timsit, Cécile Garnaud, Muriel Cornet, Patricia Pavese, Rebecca Hamidfar-Roy, Luc Foroni, Sandrine Boisset, Carole Schwebel, Danièle Maubon
P234 Invasive Candida infection in a Tunisian ICU: an observational cohort study
Islem Ouanes, Maha Abid, Hend Ben Lakhal, Saousen Ben Abdallah, Fahmi Dachraoui, Hedia Hammed, Rami Jabla, Asma Hachani, Mahdi Marzouk, Imen Abdellaoui, Chaima Ghribi, Imen Ben Ali, Lamia Ouanes-Besbes, Fekri Abroug
P235 Causes of admission in medical intensive care of patients suffering from severe psychiatric disorders
Hanane Ezzouine, Constant Aniolo Edith, Abdellatif Benslama
P236 Unplanned extubation in critical care: still to learn from local survey
Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin Sztrymf
P237 Mortality associated with nights and weekends admission to intensive care unit (ICU): results of a 9-year cohort study (2006–2014)
Vincent Brunot, Jean-Emmanuel Serre, P. Corne, Nicolas Molinari, L. Landreau, Olivier Jonquet, Kada Klouche
P238 Determinants and outcomes associated with decisions to deny admission in a Tunisian ICU
Rania Bouneb, Kaoula Meddeb, Y. Hamdaoui, H Nouira, A. Azouzi, Jihene Ayachi, Ahmed Khedher, Mohamed Boussarsar
P239 Characteristics and outcomes of patients not admitted to ICU
Nesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Mahdi Marzouk, Hedia Hammed, Asma Hachani, Hend Ben Lakhal, Chaima Ghribi, Imen Abdellaoui, Imen Ben Ali, Saousen Ben Abdallah, Lamia Ouanes-Besbes, Fekri Abroug
P240 Long-term outcomes of critically ill patients with severe acute kidney injury requiring renal replacement therapy
Vanessa Jean-Michel, Francis Couturaud, Elizabeth Moore, Pierre-Yves Egreteau, Jean-Michel Boles, Cécile Aubron
P241 Nowadays, SAPSII better predicts 1-year mortality than hospital mortality
Jean-Etienne Herbrecht, Max Guillot, Quentin Maestraggi, Charlotte Kaeuffer, Ralf Janssen-Langenstein, Sylvie L’hotellier, Sophie Hatsch, Benjamin Lebas, Alexandra Boivin, Maleka Schenck, Marie-Line Harlay, Anne Meyer, Vincent Castelain, Francis Schneider
P242 Impact of diabetes on burn injury: preliminary results from retrospective study
Amel Mokline, Imen Rahmani, Khaouther Ben Arfi, Lazhari Gharsallah, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Amen Allah Messadi
P243 Withdrawal or withholding of life-sustaining treatments decisions: Is there a risk of excessive influence of medical imaging?
Fabrice Lesage, Sylvie Séguret, Laurent Dupic, Laure De Saint Blanquat, Sylvain Renolleau
P244 Withholding and withdrawal of life-sustaining treatments in intensive care unit patients: predisposing factors and implementation
Anne-Sophie Baptiste, Hugues Georges, Pierre-Yves Delannoy, Patrick Devos, Olivier Leroy
P245 Advanced directives in an old patient with suicide attempt: analysis of ICU physicians perception
Dolores Albarracin, A. Ducousso-Lacaze, Angéline Jamet,, Julien Dufour, Séverin Cabasson, Anne Veinstein, Delphine Chatellier, Jean-Pierre Frat, René Robert
P246 Having the talk about advance directives in the daily practice: Is a stay in an intensive care unit a good opportunity?
Vivien Hong Tuan Ha, Nicolas Lau, Lucie Mimoun, Xavier Forceville
P247 Long-term outcome of patients who have withheld life support in intensive care
Adel Maamar, Stéphanie Chevalier, Vlad Botoc, Yves Le Tulzo
P248 Epidemiology of refusals in a polyvalent intensive care unit ad outcome of refused patients
Stephane Rouleau, David Schnell, Arnaud Desachy, Sylvie Calvat, Philippe Petua, Charles Lafon, Christophe Cracco
P249 Ten critical sentences you have already heard in the Intensive Care Unit and the Emergency Department, their real meanings and consequences
Nicolas Van Grunderbeeck, J. Temime, Perrine Molmy, Stephanie Barrailler, G. Gasan, Olivier Nigeon, Didier Thevenin
P250 Communication with the parents: a challenge in the pediatric intensive care unit
Agathe Béranger, Charlotte Pierron, Laure De Saint Blanquat, Sandrine Jean, Hélène Chappuy
P251 End of life in the intensive care unit: between practice and knowledge
Pierre-Marie Bertrand, Alexandra Beurton, Laetitia Bodet-Contentin, Julie Boisramé-Helms, Pierre-éRic Danin, Elsa Dubois, Elodie Gélisse, Yasemin Karaca, Pierre Mora, Nicolas de Prost, Damien Roux, Alexis Soummer, Dominique Vodovar, Committee of young intensivists of the French Society for Intensive Care Medicine (FICS)
S1 The HICU Score (Hematologic Intensive Care Unit Score): a new prognostic score for predicting 30-day and 1-year mortality of patients with hematologic malignancies admitted in ICU
Yohan Desbrosses, Guylaine Labro, Gaël Piton, Adrien Chauchet, Etienne Daguindau, François Blot, Eric Deconinck, Gilles Capellier
S2 Patients with multiple myeloma in the ICU: trends of use and outcomes over time
Akli Chermak, Adrien Joseph, Virginie Lemiale, Claire Pichereau, Marinne Baron, Emmanuel Canet, Eric Mariotte, Michaël Darmon, Elie Azoulay
S3 Impact of bone marrow aspiration on the management of adult critically ill patients
Laure Calvet, Anne Françoise Sapin, Bruno Pereira, Alexandre Lautrette, Bertrand Souweine
S4 Red blood cells transfusion in ICU: descriptive analysis of French cohort from “Age BLood Evaluation” clinical trial
Lucie Vettoretti, Sebastien Pili-Floury, Gaël Piton, Jacques Lacroix, Lucy Clayton, Elham Sabri, Laurent Bardiaux, Pierre Tiberghien, Paul Hebert, Gilles Capellier, ABLE French Investigators
S5 Graft-versus-host disease trajectories and mortality in critically ill allogeneic stem cell recipients
Claire Pichereau, Etienne Lengliné, Anne-Sophie Moreau, Eric Mariotte, Marion Venot, Sandrine Valade, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Gérard Socié, Benoît Schlemmer, Elie Azoulay
S6 Outcome of 544 patients with solid cancer in the intensive care unit: the Oncoréa study
Edith Borcoman, Virginie Lemiale, Eric Mariotte, Claire Pichereau, Emmanuel Canet, Adrien Joseph, Akli Chermak, Sandrine Valade, Marion Venot, Benoît Schlemmer, Elie Azoulay
S7 Assessing the process of ICU admission refusal in critically ill patients with hematological malignancies
Katerina Rusinova, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Antoine Rabbat, Frédéric Pène, Achille Kouatchet, Fabrice Bruneel, Julien Mayaux, François Vincent, Pierre Perez, Martine Nyunga, Elie Azoulay, Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie
S8 Neurologic and hepatic failures at ICU admission are associated with worst prognosis for patients with lymphomas
Aurélien Sutra Del Galy, Achille Kouatchet, Mélanie Mercier, Jean-François Hamel, Tommy Raveau, Marie-Pierre Moles, Aline Clavert, Mathilde Hunault-Berger, Alain Mercat, Norbert Ifrah, Aline Schmidt-Tanguy
S9 Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized polysomnographic study
Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf, Thomas Similowski
S10 Diaphragmatic paralysis after adult cardiac surgery: incidence and predicting factors
Thomas D’humières, Pierre Dupland, Pauline Issaurat, Romain Vergier, Philippe Estagnasié, Alain Brusset, Pierre Squara
S11 Ultrasound evaluation of diaphragmatic dysfunction: prognostic marker of ICU weaning failure
Cédric Carrié, Chloé Gisbert-Mora, Eline Bonnardel, Matthieu Biais, Frédéric Vargas, Gilles Hilbert
S12 A prospective multicentric study to evaluate the impact of breathing variability on clinical outcomes in mechanically ventilated patients
Côme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6 —Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, Paris
S13 Nurse-driven sedation protocol with sedation vacation and incidence of unplanned extubations
Pierre Lucas, Julien Charpentier, Michel Arnaout, Thomas Joannon,, Sébastien Lefort, Aude Marincamp, Anne-Sophie Debue, Matthieu Reffienna, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Working Group on Mechanical Ventilation
S14 Lung ultrasound enables to detect weaning-induced cardiogenic pulmonary oedema
Alexis Ferre, Max Guillot, Jean-Louis Teboul, Daniel Lichtenstein, Gilbert Meziere, Christian Richard, Xavier Monnet
S15 Pleural effusion during the weaning from mechanical ventilation: prevalence and impact
Damien Roux, Tai Pham, Alexandra Beurton, Muriel Fartoukh, Jean-Damien Ricard, Alexandre Demoule, Martin Dres
S16 Prognostic impact of left ventricular diastolic dysfunction in patients with septic shock
Céline Gonzalez, François Dalmay, Emmanuelle Begot, Nicolas Pichon, Bruno François, Anne-Laure Fedou, Catherine Chapellas, Antoine Galy, Philippe Vignon
S17 Norepinephrine exerts an inotropic effect at the early phase of human septic shock
Olfa Hamzaoui, Mathieu Jozwiak, Thomas Geffriaud, Benjamin Sztrymf, Dominique Prat, Frédéric Jacobs, Xavier Monnet, Pierre Trouiller, Christian Richard, Jean-Louis Teboul
S18 Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS: Is it good for the lung and for the heart?
Shari El-Dash, Loay Kontar, François Leleu, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Julien Maizel, Michel Slama
S19 Myocardial dysfunction during septic shock: prevalence, prognosis and role of loading conditions
Florence Boissier, Keyvan Razazi, Aurelien Seemann, Arnaud, W Thille, Nicolas de Prost, Elise Cuquemelle,, Filippo Boroli,, Alexandre Bedet, Pascal Lim, Christian Brun-Buisson, Armand Mekontso Dessap
S20 Echocardiography for the critically ill: 1-year experience of a noninvasive intensive care unit
W Brahim, R Amara, A Azouzi, Ahmed Khedher, Jihene Ayachi, Rania Bouneb, Y Hamdaoui, Kaoula Meddeb, Mohamed Boussarsar
S21 Echocardiographic indices to predict fluid responsiveness in ventilated patients with circulatory failure: which threshold for which aim?
Emmanuelle Begot, Xavier Repessé, Julie Léger, Gwenael Prat, Cyril Charron, Pierre-Yves Egreteau, Christophe Jacob, Koceila Bouferache, Loay Kontar, Julien Maizel, Michel Slama, Antoine Vieillard-Baron, Philippe Vignon
S22 Effects of norepinephrine on the right ventricle assessed by transthoracic echocardiography in the ICU
Claire Ragot, Laure Corradi, Frédéric Vargas
S23 Effect of recruitment maneuver on left ventricular systolic strain
Pablo Mercado, Julien Maizel, Loay Kontar, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Antoine Riviere, Shari El-Dash, Michel Slama
S24 Management of diabetic ketoacidosis in two pediatric intensive care units: comparison of two care protocols
Laure Maurice, Stéphane Dauger, S Julliand, Anna Deho, Fleur Le Bourgeois
S25 NUTRI-REAPED: Nutritional status on admission to the pediatric intensive care unit—a French multicentric study
Aurelien Jacquot, Frederic Valla, Bénédicte Gaillard-Le Roux, Flavie Letois, Gilles Cambonie, NutriSIP
S26 Apnea test in children for brain death diagnosis: efficacy and complications
Alexandre Salvadori, Gaia Ottonello, Stéphane Blanot, Juliette Montmayeur, Gilles Orliaguet
S27 Interest of the ultrasound in the central venous catheterization in children poses in intensive care unit
Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled Benjazia
S28 Supraclavicular approach to the innominate vein in pediatric intensive care unit: interest in the prevention of thrombosis and catheter-related blood stream infection
Flora Habas, Julien Baleine, Julia Lebouhellec, Christophe Milesi, Clementine Combes, Gilles Cambonie
S29 EPURE Study: Preliminary results on the organization of pediatric acute dialysis in 2 French-speaking countries
Maryline Chomton, Philippe Jouvet, Bruno Ranchin, Marie Alice Macher, Théophile Gaillot, EPURE Study Group
S30 Hyperglycemia in severe scorpion envenomed children: incidence and impact outcome
Mabrouk Bahloul, Najeh Baccouche, Kais Regaieg, Turki Olfa, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir Bouaziz
S31 Prehospital care and initial hospital care of pediatric patients with severe trauma hospitalized in the ICU at Grenoble University Hospital, data from the “TRENAU” trauma-system
Murielle Moine, François Xavier Ageron, Claire Jannel, Thierry Debillon, Isabelle Wroblewski
S32 Ventilator-associated pneumonia due to multi- or extensively drug-resistant Pseudomonas aeruginosa: comparison with susceptible strains
Matthieu Duprey, Nicolas Bréchot, Alexandra Aubry, Guillaume Hekimian, Matthieu Schmidt, Ania Nieszkowska, Jean Louis Trouillet, Vincent Jarlier, Alain Combes, Jean Chastre, Charles-Edouard Luyt
S33 Can we predict a secondary documented infection in patients empirically treated for an invasive candidiasis?
Sébastien Bailly, Olivier Leroy, Jean-Paul Mira, Hervé Dupont, Jean-Pierre Gangneux, Philippe Montravers, Jean-Michel Constantin, Didier Guillemot, Olivier Lortholary, Pierre-François Perrigault, Elie Azoulay, Jean-François Timsit
S34 Should aminoglycosides be administered to hematological patients with septic shock? Data from the Groupe de Recherche respiratoire en Réanimation Onco-Hématologique (Grrr-OH)
Thomas Longval, Sylvie Chevret, Fabrice Bruneel, Djamel Mokart, Frédéric Pène, Julien Mayaux, Achille Kouatchet, Martine Nyunga, Antoine Rabbat, Pierre Perez, Christine Lebert, Dominique Benoit, François Vincent, Virginie Lemiale, Elie Azoulay
S35 Is de-escalation of antimicrobial therapy safe in hematology patients?
David Schnell, Claire Montlahuc, Matthieu Resche-Rigon, Achille Kouatchet, Jean-Ralph Zahar, Michaël Darmon, Frédéric Pène, Virginie Lemiale, Antoine Rabbat, François Vincent, Fabrice Bruneel, Djamel Mokart, Elie Azoulay
S36 Pharmacokinetics and absolute bioavailability of voriconazole administered through a nasogastric tube with continuous enteral feeding to critically ill ventilated patients
Philippe Karoubi, Christophe Huang, Antoine Rabbat, Johanna Oziel, Guillaume Van Der Meersch, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Christophe Clec’h, Christophe Padoin, Yves Cohen
S37 Which optimal daily dose for linezolid in burn patients?
Amel Mokline, Lazhari Gharsallah, Imen Rahmani, Emna Gaies, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Sameh Triki, Anis Klouz, Amen Allah Messadi
S38 Predictive factors of sub-therapeutic peak concentration after a single dose of amikacin in postoperative cardiovascular critically ill patients
Mouhamed Moussa, Flavie Desrumaux
S39 Supra-therapeutic serum levels and toxicity of beta-lactam antibiotics in septic ICU patients requiring replacement therapy for acute renal failure: a single-center cohort study
Faten May, Marion Perrin, Najoua El-Helali, Jean-Claude Nguyen, Kelly Tiercelet, Stephane Ruckly, Julien Fournier, Mélanie Cherin, Cédric Bruel, Francois Philippart, Maïté Garrouste-Orgeas, Marie Dominique Kitzis, Alban Le Monnier, Jean-François Timsit, Benoit Misset
S40 Post-cardiac arrest syndrome: lessons from a monocentric retrospective study
Cyrille Mathien, Antoine Poidevin, Luis Donatti, Joy Mootien, Luis Pinto, Mathieu Egard, Gokhan Bodur, Guillaume Barberet, Carmen Ionescu, Frederique Ganster, Philippe Guiot, Khaldoun Kuteifan
S41 Out-of-hospital cardiac arrest (OHCA) score for prediction of outcome of in-hospital cardiac arrest: results of the OSPICA pilot study
Alain Mpela, Jonathan Chelly, Jennifer Brunet, Stéphane Legriel, Laurent Guérin, Romain Persichini, Alexis Soummer, Bertrand Sauneuf, Tai Pham, Thomas Hullin, Nicolas Deye, Pierre Aubertein, Mehran Monchi
S42 Delayed awakening after cardiac arrest: causes and outcome in the Parisian registry
Marine Paul, Wulfran Bougouin, Guillaume Geri, Florence Dumas, Benoit Champigneulle, Stéphane Legriel, Julien Charpentier, Jean-Paul Mira, Claudio Sandroni, Alain Cariou
S43 Incidence and characteristics of sudden unexplained cardiac death: insights from the Parisian registry
Olivier Passouant, Guillaume Geri, Florence Dumas, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jonathan Chelly, Jean-Daniel Chiche, Olivier Varenne, Jean-Paul Mira, Alain Cariou
S44 Supranormal oxygen tension is not associated with an impaired redox balance in patients resuscitated from cardiac arrest
Jean-François Llitjos, Camille Chenevier-Gobeaux, Julien Charpentier, Florence Dumas, Guillaume Geri, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jean-Paul Mira, Frédéric Pène, Frederic Batteux, Alain Cariou
S45 Impaired biological response to aspirin in comatose patients resuscitated from out-of-hospital cardiac arrest
Jean-François Llitjos, Ludovic Drouet, Sebastian Voicu, Nicolas Deye, Bruno Megarbane, Patrick Henry, Jean-Guillaume Dillinger
S46 Gender differences in coronary reperfusion after cardiac arrest
Wulfran Bougouin, Florence Dumas, Eloi Marijon, Guillaume Geri, Benoit Champigneulle, Jean-Daniel Chiche, Olivier Varenne, Christian Spaulding, Jean-Paul Mira, Xavier Jouven, Alain Cariou
S47 Prognostic factors of out-of-hospital cardiac arrests in Martinique: prospective study over a period of 29 months, about 385 cases
Dabor Resiere, A. L. Dessoy, Ruddy Valentino, C. Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y. Brouste, Bruno Megarbane, Hossein Mehdaoui
S48 Incubation of immune cells in septic plasma: effect on glucose utilization and on phenotypic expression on monocytes, polymorphonuclears and lymphocytes
Benjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
S49 Ex vivo effects of hyperglycemia on phenotype and production of reactive oxygen species by the NADPH oxidase of human immune cells in acute inflammatory response
Benjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
S52 HMGB1 induces neutrophils dysfunction after septic shock
Fabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Caroline Piau, Yves Le Tulzo, Karin Tarte, Jean-Marc Tadié
S53 Rapid mobilization of myeloid-derived suppressor cells during sepsis and relation with clinical course
Thomas Daix, Robin Jeannet, Emmanuelle Begot, Nicolas Pichon, Anne-Laure Fedou, Estelle Guérin, Philippe Vignon, Jean Feuillard, Bruno François
S54 Targeted endothelial TREM-1 deletion protects mice during septic shock
Lucie Jolly, Amir Boufenzer, Jérémie Lemarie, Kevin Carrasco, Marc Derive, Sebastien Gibot
S55 Polymicrobial sepsis inhibits tumor growth in cancer mice
Hamid Merdji, Jean-François Llitjos, Christophe Rousseau, Nadia Belaidouni, Julie Toubiana, Jean-Paul Mira, Jean-Daniel Chiche, Frédéric Pène
S56 Telestroke implementation in the biggest French region (12 millions inhabitants): the project ORTIF
Yann L’Hermitte, France Woimant, Catherine Oppenheim, Christophe Couvreur, François Dolveck
S57 Free haemoglobin concentration in patients with sickle cell disease referred to the emergency room: Is it useful?
Pierre Mora, Magali Devriese, Sophie Dupeyrat, Patrick Ray, Guillaume Lefevre, Muriel Fartoukh
S58 Evaluation of the prescription and use of antibiotics in an emergency department of a general hospital by Gyssens Method
Nicolas Roothaer, Amélie Carpentier, Fabien Vaniet, Antoine Maisonneuve, Eric Wiel
S59 High dosages of norepinephrine in trauma patients
Sébastien Canu, Emmanuelle Hammad, Francois Antonini, Marion Poirier, Laurent Zieleskiewicz, Coralie Vigne, Malik Haddam, Julie Alingrin, Marc Leone
S60 Bleeding risk of pleural procedures in patients taking antiplatelet therapy: a multicentric prospective study
Laurence Dangers, Gilles Mangiapan, Mikael Alves, Naïke Bigé, Jonathan Messika, Elise Morawiec, Mathilde Neuville, Christophe Cracco, Gaetan Beduneau, Nicolas Terzi, Isabelle Huet, Xavier Dhalluin, Nathalie Bautin, Jean Jacques Quiot, Corinne Appere De Vecchi, Thomas Similowski, Cécile Chenivesse
S61 Interest of the association fibrinogen/tranexamic acid in the management of severe postpartum hemorrhage
Khalil Tarmiz, Fehmi Ferhi, Hosni Khouadja, Affra Brahim, Mohamed Amine Bouslama, Khaled Benjazia
S62 HELLP syndrome in ICU: epidemiological, clinical and prognostic study about 112 cases
Fatma Kaaniche Medhioub, Kais Rgieg, Olfa Turki, Mariem Smaoui, Anis Chaari, Benhamida Chokri, Mabrouk Bahloul, Bouaziz Mounir
S63 Neurological complications in eclampsia
Chaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, E. El Alami, S. El Youssoufi, S. Salmi
S64 Brain water contain is dependent on plasmatic ammonemia levels in hyperammoniemic encephalopathy, a quantitative CT scan study
Nicolas Weiss, Fanny Mochel, Damien Galanaud, Louis Puybasset, Dominique Thabut, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, France
S65 Sodium phenylbutyrate administration to avoid neurological worsening in hepatic encephalopathy patients in ICU
Simona Tripon, Marion Lodey, Elsa Guiller, Maxime Mallet, Marika Rudler, Dominique Thabut, Nicolas Weiss, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, France
S66 Disruption of posteromedial large-scale neural communication predicts recovery from coma
Stein Silva, Béatrice Riu-Poulenc, Jean Ruiz, Corine Vuillaume, Francesco De Pasquale, Jean Francois Demonet
S67 Loss of sleep elements on continuous EEG monitoring is associated with mortality in patients with cardiogenic shock requiring veno-arterial extra-corporeal membrane oxygenation (ECMO)
Fabrice Sinnah, Marie Amelie Dalloz, Eric Magalhaes, Mathilde Neuville, Roland Smonig, Aguila Radjou, Bruno Mourvillier, Lila Bouadma, Jean-François Timsit, Marie Pia D’ortho, Anny Rouvel-Tallec, Romain Sonneville
S68 Protective effects of high-density lipoprotein therapy in a mouse model of ischemic stroke hemorrhagic transformation due to acute hyperglycemia
David Couret, Aurélie Catan, Brice Nativel, Cynthia Planesse, Nicolas Diotel, Olivier Meilhac
S69 Glucocorticoids as a “rescue therapy” for delayed intracranial hypertension after acute brain injury: a retrospective study
Fabian Roy-Gash, Stephane Welschbillig, Elodie Lang, Christophe Lebard, Nicolas Engrand
S70 Organ donation: early talks (ET) to relatives before occurence of brain death
Anne-Gaelle Si Larbi, Virginie Gaudin, France Bonnin, Oceane Sultan,, Alexis Soummer, Grégoire Trebbia, Cecile Hoc, Emmanuel Mathieu, Bertrand Lapergue, Frederic Bourdain, Charles Cerf
S71 Remifentanil target-controlled infusion for procedures generating pain or discomfort in the ICU: feasibility, safety and tolerance evaluation
Margot Caron, Antoine Parrot, Maxens Decavèle, Clarisse Blayau, Jean-Pierre Fulgencio, Vincent Labbe, Michel Djibre, El Mahdi Hafiani, Christophe Quesnel, Muriel Fartoukh, Tai Pham
S72 Minimizing dead-volume infusion devices leads to a reduction in hypoglycaemia in surgery patients admitted to a perioperative intensive care unit
Stephanie Genay, Bertrand Décaudin, Sabine Ethgen, Pascal Odou, Gilles Lebuffe
S73 Patient-important outcomes in randomized controlled trials in critically ill patients
Stéphane Gaudry, Jonathan Messika, Jean-Damien Ricard, Blandine Pasquet, Sylvie Guillo, Emeline Dubief, Didier Dreyfuss, Florence Tubach
S74 Epidemiology of platelets transfusion in critically ill patients
Cécile Aubron, Andrew Flint, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe Mcquilten
S75 Outcome of selected nonagenarians admitted in ICUs: a multicenter study from the Outcomerea research group
Maïté Garrouste-Orgeas, Stephane Ruckly, Francois Philippart, Anne Sylvie Dumenil, Dany Goldgran Toledano, Samir Jamali, Carole Schwebel, Lilia Soufir, Christophe Clec’h, Michaël Darmon, Bernard Allaouchiche, Laurent Argaud, Bruno Verdière, Muriel Fartoukh, Mélanie Cherin, Elie Azoulay, Jean-François Timsit
S76 A systematic follow-up consultation guarantee quality of care in intensive care unit
Martine Nyunga, Noémie Banaias, Clément Vanbaelinghem, Céline Broucqsault-Dedrie, Delphine Colling, Marie Kauv, Erik Blondeau, Patrick Herbecq
S77 Change in functional autonomy following ICU stay
Islem Ouanes, Mahdi Marzouk, Lamia Ouanes-Besbes, Rami Jabla, Chaima Ghribi, Nesrine Boujelbene, Asma Hachani, Saousen Ben Abdallah, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Fahmi Dachraoui, Fekri Abroug
S78 Outcome of Intensive Care Unit (ICU) elderly patients admitted with solid tumor
Edouard Auclin, Emmanuel Guérot, Caroline Haw-Berlemont, Julien Taieb, Stéphane Oudard, Jean-Luc Diehl, Jean-Yves Fagon, Nadia Aissaoui
S79 Risks factors for mortality in critically ill children with acute kidney injury requiring renal replacement therapy
Genevieve Morissette, Wassim Kechaou, Catherine Litalien, Aïcha Merouani, Véronique Phan, Josée Bouchard, Philippe Jouvet
S80 Epinephrine use in pediatric septic shock: a retrospective, single-center study on 117 patients
Julie Starck, Mehdi Oualha, Nelly Briand, Jean-Marc Treluyer, Sylvain Renolleau, Laurent Dupic
S81 Sickle cell disease in pediatric intensive care unit: a five-year retrospective monocentric study of 74 patients
Philippe Sachs, S Julliand, François Angoulvant, Julie Sommet, L Holvoet, M Benkerrou, Stéphane Dauger
S82 Implementation and evaluation of a paediatric nurse-driven sedation protocol in a PICU
Lélia Dreyfus, Fabienne Bordet, Sandrine Touzet, Angélique Denis, Etienne Javouhey
S83 Diagnostic evaluation and management of new-onset seizures and seizures with known epilepsy in children: a retrospective and comparative analysis
Julien Le Coz, Gérard Chéron, Rima Nabbout, Geraldine Patteau, Claire Heilbronner, Philippe Hubert, Sylvain Renolleau, Mehdi Oualha
S84 MRI sedation in children in pediatric hospital in Oran, Algeria
Nabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
S85 Neurally adjusted ventilatory assist in pediatric patients following cardiac surgery: feasibility in clinical practice and impact on ventilation pressures
Benjamin Crulli, Baruch Toledano, Nancy Poirier, Suzanne Vobecky, Guillaume Emeriaud
S86 Percutaneous central venous cannulation: a Seldinger technique versus an ultrasound guidance technique in a pediatric intensive care unit
Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled Benjazia
S87 Effect of remote ischemic preconditioning on renal resistive index in healthy volunteers
René Robert, M. Vinet, Angéline Jamet, Remi Coudroy, Arnaud W. Thille
S88 Peak concentration of high-dose AMIKACIN does not affect renal recovery at day 90: a retrospective study of 93 patients in a single medical Intensive Care Unit
Camille Vinclair, Romain Sonneville, Bruno Mourvillier, Mathilde Neuville, Roland Smonig, Eric Magalhaes, Guillaume Voiriot, Aguila Radjou, Jean-François Soubirou, Stephane Ruckly, Lila Bouadma, Jean-François Timsit
S89 Resuscitating chronic hypertensive patient with a high mean arterial pressure target during septic shock protects against acute renal failure
Julie Boisramé-Helms, Ferhat Meziani, Jean-François Hamel, François Beloncle, Jean-Louis Teboul, Peter Radermacher, Pierre Asfar
S90 Guidewire exchange vs new-site placement for temporary dialysis catheters insertion in ICU patients: Is there a greater risk of colonization or dysfunction?
Elisabeth Coupez, Jean-François Timsit, Stephane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohé, Maïté Garrouste-Orgeas, François Vincent, Sophie Cayot, Michaël Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand Souweine
S92 Assessment of chloride levels on renal function after cardiac arrest
Cláudia Righy Shinotsuka, Pietro Caironi, Paola Villois, Vito Fontana, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
S93 Sustained low-efficiency dialysis with regional citrate anticoagulation is safe for patients with acute liver failure or cirrhosis
Franck Pourcine, Ly Vong, Jonathan Chelly, Sebastien Jochmans, Oumar Sy, Olivier Ellrodt, Nathalie Rolin, Jean-Emmanuel Alphonsine,, Claire Marie Weyer, Jean Serbource-Goguel, Benoit Akando, Razach Abdallah, Mehran Monchi, Christophe Vinsonneau
S94 The new biomarker Nephrocheck™ can discriminate the population of septic shock patients with an AKIN 1 or 2 acute renal failure who will not progress toward the AKIN 3 level
Morgane Wetzstein, Loay Kontar, Dimitri Titeca, François Brazier, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien Maizel
S95 Is thrombocytopenia an early prognostic marker in septic shock?
Nadiejda Antier, Christine Binquet, Sandrine Vinault, Ferhat Meziani, Julie Boisramé-Helms, Jean-Pierre Quenot
S96 Assessment of fibrinolysis in critically ill patients
Yasmina Serroukh, Karim Zouaoui Boudjeltia, Anne Joosten, Alexandre Rousseau, Patrick Biston, Michael Piagnerelli
S97 Early detection of disseminated intravascular coagulation during septic shock: a multicentre prospective study
Xavier Delabranche, Jean-Pierre Quenot, Thierry Lavigne, Emmanuelle Mercier, Bruno François, François Severac, Lélia Grunebaum, Laure Stiel, Florence Toti, Ferhat Meziani, Julie Boisramé-Helms, CRICS Network
S98 Activation or dysregulation of coagulation during septic shock: How to stratify patients in 2016?
Xavier Delabranche, Thierry Lavigne, Laure Stiel, Julie Boisramé-Helms, Achille Kouatchet, Maleka Schenck, Lélia Grunebaum, Yoganaden Mootien, Nicolas Lerolle, Ferhat Meziani
S99 Associated factors to early high blood pressure after weaning vasopressors during septic shock
Rostane Gaci, Jean-Romain Garric, Damien Barraud, Marie Conrad, Aurélie Cravoisy-Popovic, Jérémie Lemarie, Charles-Henri Maigrat, Pierre-Edouard Bollaert, Sébastien Gibot
S100 Impact of endotracheal intubation on septic shock outcome: a post hoc analysis of the SEPSISPAM trial
Agathe Delbove, Cédric Darreau, Nicolas Lerolle, Pierre Asfar, CNER DESC réanimation grand ouest
S101 Corporal Contention at the Onset of Septic shock (COCOONs): study protocol and preliminary results of a phase II trial
Auguste Dargent, Audrey Large, Agnès Soudry-Faure, Sebastien Prin, Pierre-Emmanuel Charles, Jean-Pierre Quenot, COCOONs Study Group
S102 Veno-arterial ECMO for refractory cardiogenic shock following cardiac arrest
Marc Pineton De Chambrun, Nicolas Bréchot, Guillaume Hekimian, Guillaume Lebreton, Matthieu Schmidt, Pierre Demondion, Ania Nieszkowska, Jean Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes, Charles-Edouard Luyt
S103 Outcome of patients with pulmonary embolism treated by extra-corporeal life support (ECLS)
Jean-Christophe Blanchard, François Belon, Sydney Chocron, Nicolas Meneveau, Loïc Barrot, Nicolas Belin, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Gaël Piton, Gilles Capellier
S104 Acute massive pulmonary embolism rescued by veno-arterial extracorporeal membrane oxygenation
Filippo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hékimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
S105 Outcome of patient recused for extracorporeal membrane oxygenation for ARDS
Pierre-Emmanuel Meynieu, Benjamin Repusseau, Virginie Perrier, Arnaud Germain, Antoine Dewitte, Hadrien Roze, Alexandre Ouattara
S106 Refractory electrical storm rescued by venoarterial extracorporeal membrane oxygenation
Guillaume Baudry, Guillaume Lebreton, Guillaume Hekimian, Nicolas Brechot, Ania Nieszkowska, Charles-Edouard Luyt, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Matthieu Schmidt
S107 Incidence and determinants of severe bleeding among patients with extra-corporeal membrane oxygenation (ECMO)
Lucie Hierle, François Belon, Guillaume Besch, Sebastien Pili-Floury, Loïc Barrot, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Nicolas Belin, Gaël Piton, Gilles Capellier
S108 Venovenous extracorporeal membranous oxygenation device-related infections and colonizations
Guillemette Thomas, Jean-Marie Forel, Nadim Cassir, Sami Hraiech, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian
S109 High emergency lung transplant for end-stage cystic fibrosis: ECMO as a bridge to transplant for patients with temporary contraindications
Grégoire Trebbia, Kiruba Govindaradjou, Alexis Soummer, Jérôme Devaquet, Clément Picard, Antoine Roux, François Parquin, Elise Cuquemelle, Morgan Leguen, Marie-Louise Felten, Edouard Sage, Alain Chapelier, Charles Cerf
S110 Malignant acute respiratory distress syndrome in diffuse lepidic adenocarcinoma (DLA): diagnosis and current issues
Maxens Decavèle, Antoine Parrot, Michael Duruisseaux, Jocelyne Fleury, Martine Antoine, Marie-France Carette, Marie Wislez, Muriel Fartoukh
S111 Acute respiratory failure from pulmonary leukemic infiltrates: diagnosis contribution of high-resolution computed tomography (HRCT)
Claire Givel, Virginie Lemiale, Constance De Margerie-Mellon, Etienne Lengliné, Leïla Mourtada, François Vincent, Akli Chermak, Eric De Kerviler, Elie Azoulay
S112 Characteristics and outcome of patients with interstitial lung disease admitted to the intensive care unit over a 15-year period
Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Olivia Freynet, Guillaume Van Der Meersch, Johanna Oziel, Christophe Huang, Philippe Karoubi, Christophe Clec’h, Yves Cohen
S113 Outcome of patients admitted in intensive care unit for acute manifestation of small vessel vasculitis
Antoine Kimmoun, Elisabeth Baux, Vincent Das, Nicolas Terzi, Patrice Talec, Stephan Ehrmann, Guillaume Geri, Steven Grange, Nadia Anguel, Alexandre Demoule, Anne-Sophie Moreau, Elie Azoulay, Jean-Pierre Quenot, Julie Boisramé-Helms, Guillaume Louis, Romain Sonneville, Nicolas Girerd, Bruno Levy
S114 A monocenter retrospective study of predictive factors of prolonged intensive care unit hospitalization after a whole lung lavage procedure for patients with pulmonary alveolar proteinosis
Pauline Tallon, Alice Hadchouel-Duvergé, Nadège Salvi, Pascale Cairet, Jean-Marc Treluyer, Mehdi Oualha, Fabrice Lesage, Laure De Saint Blanquat, Sylvain Renolleau, Christophe Delacourt, Laurent Dupic
S115 Free fatty acids plasma profile during acute chest syndrome in adult patients with sickle cell disease: a pilot study
Blandine Lefebvre Blandine, Guillaume Lefevre, Laurence Beraud, Pierre Mora, Zoé Coppere, Antonin Lamaziere, François Lionnet, Muriel Fartoukh
S116 Extravascular lung water and lung ultrasound to predict severe primary graft dysfunction following lung transplantation
Samuel Lehingue, Christophe Guervilly, Stéphanie Dizier, Laurent Zieleskiewicz, Xavier D’journo, Guillemette Thomas, Fanny Klasen, Mélanie Adda, Antoine Roch, Forel Jean-Marie, Marc Leone, Laurent Papazian
S117 Results of the international multicentric prospective observational study Phase Angle Project: phase angle measured by bioimpedance analysis at intensive care unit (ICU) admission predicts 28-day survival
Ronan Thibault, Anne-Marie Makhlouf, Aurélien Mulliez, Cristina Gonzalez, Sylvain Dadet, Gintautas Kekstas, Jean-Charles Preiser, Kozjek Nada Rotovnik, Isabel Ceniceros Rozalen, Kinga Kupczyk, Zeljko Krznaric, Fabienne Tamion, Noël Cano, Claude Pichard, Phase angle project Investigators
S118 Nutrireaped: a survey of physician nutrition practices and knowledge in French-speaking pediatric intensive care units
Bénédicte Gaillard-Le Roux, Aurelien Jacquot, Corinne Jotterand, Shancy Rooze, Clemence Moullet, Flavie Letois, Frederic Valla
S119 A computerized tool increases compliance to caloric and protein targets and may lower mortality in neutropenic hematologic patients in the ICU: the NUTCHOCO study: NUTritionnal Care in Hematologic Oncologic patients and Critical Outcome
Aurélia Henin, Florence Ettori, Christophe Zemmour, Laurent Chow-Chine, Jeanpaul Brun, Antoine Sannini, Magali Bisbal, Marion Faucher, Jean Marie Boher, Djamel Mokart
S120 Systemic evaluation of intakes in patients receiving noninvasive ventilation: the STARVE study
Michel Arnaout, Aude Marincamp, Matthieu Reffienna, Anne-Sophie Debue, Pierre Lucas, Audrey Feltry, Julien Charpentier, Benoit Champigneulle, Wulfran Bougouin, Guillaume Geri, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Groupe de travail sur la ventilation
S121 Computerized glucose control in the ICU
Salah Adel Ben, Juliette Audibert, Alexandre Conia, Olivier Gontier, Mouldi Hamrouni, Thierry Lherm, Abdelkader Ouchenir, Jérôme Rétif, Alain Proudhom, Chantal Lagardere, Stéphane Tissot, Pierre Kalfon
S122 Toxicodynetics in mono-intoxications with oxazepam and nordiazepam: an approach to a better understanding of drug–drug interaction
Lynn Sacre, Antoine Villa, Alaywa Khadija, Robert Garnier, Frederic Baud
S123 Rapid triage of victims suspected of a chemical attack: a one-page sheet allowing identifying the toxidrome: the doctors without borders (MSF) experience
Frederic Baud, Robert Garnier, Brigitte Vasset, Annette Heinzelman
S124 Low sensitivity of toxicological analysis in daily practice of acute poisonings: an endless rupture in spite of modern technology
Frederic Baud, Alaywa Khadija, Romain Jouffroy, Lionel Lamhaut
S125 Context of the request and interest of toxicological screening in a medical intensive care unit
Elsa Démarest Durand, Fabienne Tamion, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Patricia Compagnon, Steven Grange
S126 Acute poisoning in emergency department
Neila Maaroufi, Dhaouadi Mahassen
S127 Management of poising: Are there differences between specialised and non-specialised emergencies?
A M’rad, Alia Jebri, Youssef Blel, Hend Ben Lakhal, Messaouda Khelfa, Nozha Brahmi, H Thabet
S128 Jusquiame poisoning: report of a family intoxication
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
S129 Morbi-mortality of poisoning episodes in Paris region: a test for a multisource surveillance system
Céline Legout, Robert Garnier, Antoine Villa, Frederic Baud, Philippe Aegerter, Anne Castot-Villepelet
S130 Atypical pneumonia in the ICU: a retrospective multicentric study
Sandrine Valade, Virginie Lemiale, Laurent Argaud, Frédéric Pène, Laurent Papazian, Fabrice Bruneel, Amélie Seguin, Achille Kouatchet, Johanna Oziel, Olivier Lesieur, Florence Boissier, Bruno Megarbane, Naïke Bigé, Noelle Brule, Anne-Sophie Moreau, Alexandre Lautrette, Elie Azoulay
S131 Severe leptospirosis: analysis of mortality and organ failures in 134 patients hospitalized in intensive care unit
Benjamin Delmas, Julien Jabot, Paul Chanareille, Jérôme Allyn, Nicolas Allou, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David Vandroux
S132 In severe pneumonia, respiratory viruses are not passengers but pathogens
Guillaume Voiriot, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Mathilde Neuville, Caroline Morbieu, Charles Burdet, Aguila Radjou, François-Xavier Lescure, Roland Smonig, Laurence Armand-Lefevre, Bruno Mourvillier, Yazdan Yazdanpanah, Jean-François Soubirou, Stephane Ruckly, Nadira Houhou-Fidouh, Jean-François Timsit
S133 Critical care management of patients with HHV8-associated disorders
Marine Cazaux, Claire Pichereau, Marion Venot, Sandrine Valade, Virginie Lemiale, Akli Chermak, Emmanuel Canet, Le Goff Jérôme, Veronique Meignin, David Boutboul, Lionel Galicier, Elie Azoulay, Eric Mariotte
S134 Emerging moulds in critically ill patients: epidemiological trends, clinical features and ICU outcome
Laura Platon, Philippe Rispail, Vincent Brunot, N. Besnard, Patrice Ceballos, Kada Klouche
S135 Intensive care unit-associated bloodstream infection and ventilator-associated pneumonia in critically ill cancer patients: a 12-year retrospective study
Annabelle Stoclin, Federico Rotolo, Muriel Wartelle, Yosr Hicheri, Sylvia Maillet, Elisabeth Chachaty, Jean-Pierre Pignon, François Blot
S136 Is diabetes mellitus a risk factor for intensive care unit-acquired infections?
Marion Venot, Stephane Ruckly, Christophe Clec’h, Michaël Darmon, Bernard Allaouchiche, Dany Goldgran Toledano, Maïté Garrouste-Orgeas, Christophe Adrie, Jean-François Timsit, Elie Azoulay
PHYSIOTHERAPISTS ABSTRACTS
O85 Short-term physiological effects of nasal high-flow in healthy subjects. Impact of flow rates on the work of breathing
Mathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François Lellouche
O86 High-flow therapy allows a decreased workload of accessory respiratory muscles
Emilie Bialais, Dupuis Julie, Laura Paoloni, Gregory Reychler, Xavier Wittebolle
O87 Patient perception and feasibility of early mobilization in the critically ill
Cheryl Hickmann, Diego Castanares-Zapatero, Emilie Bialais, Jonathan Dugernier, Antoine Tordeur, Lise Colmant, Xavier Wittebole, Giuseppe Tirone, Jean Roeseler, Pierre-François Laterre
P252 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practice
Lorraine Ducroux, Sylvie L’hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent Castelain
P253 Motor imagery and functional magnetic resonance imaging
Claire Kemlin, Eric Moulton, Charlotte Rosso
P254 Thoracic ultrasound: potential new tool for physiotherapists in respiratory management—a narrative review
Aymeric Le Neindre, Silvia Mongodi, Francois Philippart, Béaïd Bouhemad
P255 In vitro comparison of a vibrating-mesh nebulizer operating in expiratory synchronized and inspiratory nebulization modes during noninvasive ventilation
Joana Rodrigues, Caroline Botteau, Jonathan Dugernier, Giuseppe Liistro, Gregory Reychler, Jean-Bernard Michotte
P256 Evaluation of a new system of oxygen administration: the Wenoll system
Frédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Frank Vantrimpont, Sharam Machayeckhi
P257 Evaluation of three portable oxyconcentrators in high altitude
Frédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Charbel Elkhawand, Frank Vantrimpont, Sharam Machayeckhi, Frank Vermeesh
doi:10.1186/s13613-016-0114-z
PMCID: PMC4912513  PMID: 27316915
8.  Sickle erythrocytes and platelets augment lung leukotriene synthesis with downregulation of anti-inflammatory proteins: relevance in the pathology of the acute chest syndrome 
Pulmonary Circulation  2014;4(3):482-495.
Initiation, progression, and resolution of vaso-occlusive pain episodes in sickle cell disease (SCD) have been recognized as reperfusion injury, which provokes an inflammatory response in the pulmonary circulation. Some 5-lipoxygenase (5-lox) metabolites are potent vasoconstrictors in the pulmonary circulation. We studied stimulation of production of the inflammatory eicosanoids leukotrienes (LTs) and prostaglandin E2 (PGE2) by isolated rat lungs perfused with sickle (HbSS) erythrocytes. Our hypothesis is that HbSS erythrocytes produce more LTs than normal (HbAA) erythrocytes, which can induce vaso-occlusive episodes in SCD patients. Lung perfusates were collected at specific time points and purified by high-pressure liquid chromatography, and LTC4 and PGE2 contents were measured by enzyme-linked immunosorbent assay (ELISA). Rat lung explants were also cultured with purified HbAA and HbSS peptides, and 5-lox, cyclooxygenase 1/2, and platelet-activating factor receptor (PAFR) proteins were measured by Western blotting, while prostacyclin and LTs produced by cultured lung explants were measured by ELISA. Lung weight gain and blood gas data were not different among the groups. HbSS-perfused lungs produced more LTC4 and PGE2 than HbAA-perfused lungs: 10.40 ± 0.62 versus 0.92 ± 0.2 ng/g dry lung weight (mean ± SEM; P = 0.0001) for LTC4. Inclusion of autologous platelets (platelet-rich plasma) elevated LTC4 production to 12.6 ± 0.96 and 7 ± 0.60 ng/g dry lung weight in HbSS and HbAA perfusates, respectively. HbSS lungs also expressed more 5-lox and PAFR. The data suggest that HbSS erythrocytes and activated platelets in patient’s pulmonary microcirculation will enhance the synthesis and release of the proinflammatory mediators LTC4 and PGE2, both of which may contribute to onset of the acute chest syndrome in SCD.
doi:10.1086/677363
PMCID: PMC4278608  PMID: 25621162
pulmonary circulation; 5-lipoxygenase; leukotriene receptors; PAF receptor; cyclooxygenase; prostaglandins
9.  Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for Stroke 
PLoS ONE  2015;10(8):e0134193.
Hypercoagulability in sickle cell disease (SCD) is associated with multiple SCD phenotypes, association with stroke risk has not been well described. We hypothesized that serum levels of biomarkers of coagulation activation correlate with high transcranial Doppler ultrasound velocity and decreases with blood transfusion therapy in SCD patients. Stored serum samples from subjects in the Stroke Prevention in Sickle Cell Anemia (STOP) trial were analyzed using ELISA and protein multiplexing techniques. 40 subjects from each treatment arm (Standard Care [SC] and Transfusion [Tx]) at three time points—baseline, study exit and one year post-trial and 10 each of age matched children with SCD but normal TCD (SNTCD) and with normal hemoglobin (HbAA) were analyzed. At baseline, median vWF, TAT and D-dimer levels were significantly higher among STOP subjects than either HbAA or SNTCD. At study exit, median hemoglobin level was significantly higher while median TCD velocity was significantly lower in Tx compared to SC subjects. Median vWF (409.6 vs. 542.9 μg/ml), TAT (24.8 vs. 40.0 ng/ml) and D-dimer (9.2 vs. 19.1 μg/ml) levels were also significantly lower in the Tx compared to the SC group at study exit. Blood levels of biomarkers coagulation activation/thrombin generation correlated positively with TCD velocity and negatively with number of blood transfusions. Biomarkers of coagulation activation/thrombin generation were significantly elevated in children with SCD, at high risk for stroke. Reduction in levels of these biomarkers correlated with reduction in stroke risk (lower TCD velocity), indicating a possible role for hypercoagulation in SCD associated stroke.
doi:10.1371/journal.pone.0134193
PMCID: PMC4549306  PMID: 26305570
10.  Neonatal Screening and the Clinical Outcome in Children with Sickle Cell Disease in Central India 
PLoS ONE  2016;11(1):e0147081.
Background
Sickle cell disease (SCD) is a major health burden in India. The objective of the study was to establish a neonatal screening program and to understand the clinical course of children with SCD in central India.
Methods and Findings
Pregnant mothers were screened for sickle hemoglobin using the solubility test. Babies were screened by high performance liquid chromatography if the mother was positive for sickle hemoglobin. The diagnosis was confirmed by molecular analysis. They received early prophylactic treatment and vaccination. Of 2134 newborns screened, 104 were sickle homozygous (SS), seven had sickle β-thalassemia (S-β thal) and 978 were sickle heterozygous (AS). The other hemoglobin abnormalities detected included HbS -δβ thalassemia-1, HbSD disease-2, HbE traits-5, β-thalassemia traits-4, alpha chain variants-3 and HbH disease-1.These babies were followed up regularly for hematological and clinical evaluation. Pain, severe anemia requiring blood transfusions and acute febrile illness were the major complications with 59.7, 45.1 and 42.6 cases per 100 person years. Fetal hemoglobin (HbF) levels were inversely associated with vaso-oclussive crisis (VOC) and severe anemia while presence of alpha thalassemia increased the rate of painful events and sepsis. Six early deaths occurred among the SS babies.
Conclusion
A systematic follow up of this first newborn SCD cohort in central India showed that 47% of babies presented within 1 year of age. In spite of the presence of the Arab-Indian haplotype many babies had severe manifestations.
doi:10.1371/journal.pone.0147081
PMCID: PMC4718540  PMID: 26785407
11.  Plasma interleukin-1β(beta) concentration is associated with stroke in sickle cell disease 
Cytokine  2009;49(1):39-44.
The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participated in multi-center stroke prevention (STOP) study, to determine if plasma inflammatory protein concentration is associated with the outcome of stroke in the STOP study. Thirty-nine plasma samples from HbSS participants with elevated TCD who had no stroke, HbSS-NS (n=13) or had stroke, HbSS-S (n=13), HbSS steady-state controls (n=7) and controls with normal hemoglobin, HbAA (n=6), were analyzed simultaneously for 27 circulating inflammatory proteins. Logistic regression and receiver operating characteristics curve analysis of stroke on plasma inflammatory mediator concentration, adjusted for age and gender, demonstrated that interleukin-1β (IL-1β) was protective against stroke development (HbSS-NS = 19, 17–23, HbSS-S = 17, 16 – 19 pg/mL, median and 25th–75th percentile; Odds ratio = 0.59, C.I. = 0.36 – 0.96) and was a good predictor of stroke (area under curve = 0.852). This result demonstrates a strong association of systemic inflammation with stroke development in HbSS via moderately increased plasma IL-1β concentration, which is furthermore associated with a decreased likelihood of stroke in HbSS.
doi:10.1016/j.cyto.2009.10.002
PMCID: PMC2808442  PMID: 19900820
Sickle cell; Stroke; Interleukin-1β; Cytokine; Chemokine
12.  Prospective Echocardiography Assessment of Pulmonary Hypertension And Its Potential Etiologies In Children With Sickle Cell Disease 
The American journal of cardiology  2009;104(5):713-720.
Pulmonary hypertension (PH) is associated with adverse outcomes in adults with sickle cell disease (SCD) but its importance in children is less clear. We define the incidence and etiologies of PH in pediatric patients with SCD. Children with SCD (n = 310) and matched controls (n = 54) were prospectively enrolled under basal conditions. Participants underwent echocardiography, pulse oximetry, 6-minute walk, and hematologic testing. Echocardiographic measures were compared between SCD and control subjects before and after adjusting for hemoglobin. Correlation of echocardiographic and clinical parameters was performed. Tricuspid regurgitation velocity (TRV) was elevated compared to controls (2.28 vs. 2.10 m/s, p <0.0001). Increased TRV was associated with left ventricular diastolic diameter, hemoglobin, and estimated left atrial pressure. TRV remained elevated when controlled for left ventricular diameter and left atrial pressure. An echocardiography-derived pulmonary resistance was not significantly different between SCD and control patients, although it was elevated in the SCD subgroup with elevated TRV. When controlled for hemoglobin, TRV was no longer statistically different, but pulmonary insufficiency velocity, septal wall thickness and estimated pulmonary resistance were statistically higher. TRV, pulmonary insufficiency end diastolic velocity, and markers of increased cardiac output correlated with indicators of adverse functional status including history of acute chest syndrome, stroke, transfusions, and 6-minute walk. In conclusion, children with SCD have mildly increased TRV that correlated with increased cardiac output and left ventricular filling pressures. Hemoglobin adjusted analysis also suggests contribution of primary vascular changes.
doi:10.1016/j.amjcard.2009.04.034
PMCID: PMC3197734  PMID: 19699350
Pulmonary hypertension; Tricuspid regurgitation; Pulmonary vascular resistance; Sickle cell
13.  Transcranial Doppler Screening and Prophylactic Transfusion Program Is Effective in Preventing Overt Stroke in Children With Sickle Cell Disease 
The Journal of pediatrics  2010;157(3):479-484.
Objective
To assess the impact of our transcranial doppler ultrasonography (TCD) program on the incidence of first stroke and the rate of transfusion for stroke prevention in children with sickle cell disease.
Study design
In this single-institution, retrospective study, we compared the incidence of stroke and of transfusion for stroke prevention in 475 patients followed in the 8-year period prior to instituting TCD screening to the rate in 530 children in the 8-year period afterwards.
Results
The incidence of overt stroke in the pre-TCD period was 0.67 per 100 patient-years, compared with 0.06 per 100 patient-years in the post-TCD period (p<0.0001). Of the two strokes in the post-TCD period, one occurred in a child too young for the screening protocol and one in a child with high velocities solely in the anterior cerebral arteries. The rate of transfusion therapy for stroke prevention increased from 0.67 per 100 patient-years to 1.12 per 100 patient-years since instituting our program (p=0.008).
Conclusions
Our program has been successful in reducing the rate of first overt stroke, but with increased use of transfusion. Additional modifications to screening might further reduce the risk of first stroke, and studies of alternative treatments may be beneficial.
doi:10.1016/j.jpeds.2010.03.007
PMCID: PMC2931594  PMID: 20434165
Sickle cell disease; stroke; Transcranial Doppler ultrasonography; blood transfusion; pediatric hematology
14.  Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans—United States, 1997–2012 
Pediatric blood & cancer  2015;62(12):2076-2081.
Background
Approximately 10–20% of children with sickle cell disease (SCD) develop stroke, but few consistent national estimates of the stroke burden for children with SCD exist. The purpose of this study is to determine the proportion of diagnosed stroke among African-American pediatric discharges with and without SCD.
Procedure
Records for African-Americans aged 1–18 years in the Kids' Inpatient Database (KID) 1997–2012 with ≥1 ICD-9-CM diagnosis code for stroke were included. Data were weighted to provide national estimates. A total of 2,994 stroke cases among African-American children were identified. Diagnoses co-existing with ischemic or hemorrhagic stroke were frequency ranked separately.
Results
From 1997 through 2012, SCD was present in 24% of stroke discharges, with 89% being ischemic stroke. For hospital discharges of African-American children, SCD is the highest co-existing risk factor for ischemic stroke (29%). Stroke in children with SCD occurred predominantly in children aged 5–9 years, older than previously reported. The trend of stroke discharges significantly decreased for children with SCD from 1997 to 2012 for children aged 10–14 years.
Conclusions
SCD is a leading risk factor to pediatric stroke in African-American children. Reducing the number of strokes among children with SCD would have a significant impact on the rate of strokes among African-American children. Preventative intervention may be modifying initial age of presentation of stroke in children with SCD.
doi:10.1002/pbc.25655
PMCID: PMC4624016  PMID: 26174777
hemorrhagic stroke; hospitalization; ischemic stroke; sickle cell disease
15.  Adult Sickle Cell Disease 
Objectives:
Sickle cell disease (SCD) is an inherited disease caused by an abnormal type of haemoglobin. It is one of the most common genetic blood disorders in the Gulf area, including Oman. It may be associated with complications requiring intensive care unit (ICU) admission. This study investigated the causes of ICU admission for SCD patients.
Methods:
This was a retrospective analysis of all adult patients ≥12 years old with SCD admitted to Sultan Qaboos University Hospital (SQUH) ICU between 1st January 2005 and 31st December 2009.
Results:
A total number of 49 sickle cell patients were admitted 56 times to ICU. The reasons for admission were acute chest syndrome (69.6%), painful crises (16.1%), multi-organ failure (7.1%) and others (7.2%). The mortality for SCD patients in our ICU was 16.1%. The haemoglobin (Hb) and Hb S levels at time of ICU admission were studied as predictors of mortality and neither showed statistical significance by Student’s t-test. The odds ratio, with 95% confidence intervals, was used to study other six organ supportive measures as predictors of mortality. The need for inotropic support and mechanical ventilation was a good predictor of mortality. While the need for non-invasive ventilation, haemofiltration, blood transfusions and exchange transfusions were not significant predictors of mortality.
Conclusion:
Acute chest syndrome is the main cause of ICU admission in SCD patient. Unlike other supportive measures, the use of inotropic support and/or mechanical ventilation is an indicator of high mortality rate SCD patient.
PMCID: PMC3327564  PMID: 22548136
Anemia; Sickle cell; Acute chest syndrome; Oman
16.  The Excess Burden of Stroke in Hospitalized Adults with Sickle Cell Disease 
American journal of hematology  2009;84(9):548-552.
Objective
To compare the relative rates and risk factors associated with stroke in adults vs. children with sickle cell disease (SCD) in the U.S. over the last decade.
Methods
We identified incident strokes in patients with SCD using ICD-9 codes for acute stroke and SCD and the California Patient Discharge Databases. We estimated SCD prevalence by using the incidence of SCD at birth with adjustment for early mortality from SCD.
Results
We identified 255 acute strokes (70 primary hemorrhagic and 185 ischemic) among 69,586 hospitalizations for SCD-related complications from 1998–2007. The rate of stroke in children [<18 years old (310/100,000 person-years)] was similar to young adults [18 to 34 years old (360/100,000 person-years)], but much higher in middle-aged [35 to 64 years old (1160/100,000 person-years)] and elderly adults [≥65 years old (4700/100,000 person-years)]. Stroke was associated with hypertension in children and hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, and renal disease in adults. Most acute strokes (75%) and in-hospital deaths from stroke (91%) occurred in adults.
Interpretation
Our results suggest that the rate of stroke in SCD peaks in older adults and is 3-fold higher than rates previously reported in African-Americans of similar age (35 to 64 years) without SCD. Stroke in SCD is associated with several known adult risk factors for ischemic and hemorrhagic stroke. Studies for the primary and secondary prevention of stroke in adults with SCD are urgently needed.
doi:10.1002/ajh.21476
PMCID: PMC2737603  PMID: 19623672
Stroke; sickle cell disease; epidemiology; transfusion
17.  Trends in Blood Transfusion Among Hospitalized Children With Sickle Cell Disease 
Pediatric blood & cancer  2013;60(11):1753-1758.
Background
Blood transfusions represent a major therapeutic option in acute management of sickle cell disease (SCD). Few data exist documenting trends in transfusion among children with SCD, particularly during hospitalization.
Procedure
This was an analysis of cross-sectional data of hospital discharges within the Kid’s Inpatient Database (years 1997, 2000, 2003, 2006, 2009). Hospitalizations for children (0–18 years) with a primary or secondary SCD-related diagnosis were examined. The primary outcome was blood transfusion. Trends in transfusion were assessed using weighted multivariate logistic regression in a merged dataset with year as the primary independent variable. Co-variables consisted of child and hospital characteristics. Multivariate logistic regression was conducted for 2009 data to assess child and hospital-level factors associated with transfusion.
Results
From 1997 to 2009, the percentage of SCD-related hospitalizations with transfusion increased from 14.2% to 28.8% (P <0.0001). Among all SCD-related hospitalizations, the odds of transfusion increased over 20% for each successive study interval. Hospitalizations with vaso-occlusive pain crisis (OR 1.35, 95% CI 1.27–1.43) or acute chest syndrome/pneumonia (OR 1.24, 95% CI 1.13–1.35) as the primary diagnoses had the highest odds of transfusion for each consecutive study interval. Older age and male gender were associated with higher odds of transfusion.
Conclusions
Blood transfusion is increasing over time among hospitalized children with SCD. Further study is warranted to identify indications contributing to the rise in transfusions and if transfusions in the inpatient setting have been used appropriately. Future studies should also assess the impact of rising trends on morbidity, mortality, and other health-related outcomes.
doi:10.1002/pbc.24630
PMCID: PMC4091906  PMID: 23775719
epidemiology; health care utilization; outcomes research; sickle cell disease
18.  The Acute Chest Syndrome in Cameroonian children living with sickle cell disease 
BMC Pediatrics  2015;15:131.
Background
Although sub-Saharan Africa (SSA) is particularly affected by sickle cell disease (SCD), there is dearth of research on this topic in the region, specifically targeting the magnitude of SCD-related complications. We therefore conducted this study to determine the burden of acute chest syndrome (ACS) and describe its clinical and therapeutic aspects among SCD children in Cameroon, a SSA country.
Methods
This was a retrospective study carried-out from September 2013 to June 2014 at the SCD unit of the Mother and Child Centre of the Chantal Biya Foundation, a pediatric reference centre in Yaoundé, Cameroon. We enrolled all SCD children with confirmed diagnosis of ACS, and recorded their clinical presentation at admission along with their evolution during hospitalization.
Results
Twenty one cases of ACS were identified during the study period, from 338 hospitalizations of children with SCD. Ages ranged from 11 months to 16 years with a mean (standard deviation) of 5.5 (3.4) years, and a male/female sex ratio of 3.2/1. We noticed relatively low levels of HbF, from 6.4 to 21.9 % with a mean of 14.6 % (6.0 %). The three main symptoms at admission were fever (90.5 %), cough (81 %) and chest pains (28.6 %). Two patients (9.5 %) developed ACS 2 days after admission. The mean values of leukocytes, neutrophils, serum CRP, serum LDH and hemoglobin were respectively 32479.4 (17862.3)/mm3, 23476 (11543.7)/mm3, 228.2 (132.6) mg/l, 3452.3 (2916.3) IU/l and 6.5 (1.2) g/dl. The main localizations of radiological alveolar consolidations were the lower lobes (90.5 %). Treatment associated broad-spectrum antibiotics (100 %), hydration (100 %), analgesics (43.2 %), whole blood transfusion (66.7 %), and oxygen supplementation (33.3 %). Blood transfusion significantly improved hemoglobin level (p = 0.039). The duration of hospitalization, the mean of which was 6.8 (3.1) days, was influenced by none of the tested variables (all p values > 0.05).
Conclusion
ACS is frequent among SCD children in our milieu. Its etiologies seem to be multifactorial. Patients’ parents should be educated to recognize early signs and symptoms of the disease, and consult rapidly. Additionally, clinicians must be trained to diagnose ACS, and manage it promptly and efficiently to avoid its related catastrophic consequences.
doi:10.1186/s12887-015-0454-0
PMCID: PMC4578678  PMID: 26391669
Acute chest syndrome; Sickle cell disease; Children; Cameroon; Sub-Saharan Africa
19.  Associations between Stroke Mortality and Weekend Working by Stroke Specialist Physicians and Registered Nurses: Prospective Multicentre Cohort Study 
PLoS Medicine  2014;11(8):e1001705.
In a multicenter observational study, Benjamin Bray and colleagues evaluate whether weekend rounds by stroke specialist physicians, or the ratio of registered nurses to beds on weekends, is associated with patient mortality after stroke.
Please see later in the article for the Editors' Summary
Background
Observational studies have reported higher mortality for patients admitted on weekends. It is not known whether this “weekend effect” is modified by clinical staffing levels on weekends. We aimed to test the hypotheses that rounds by stroke specialist physicians 7 d per week and the ratio of registered nurses to beds on weekends are associated with mortality after stroke.
Methods and Findings
We conducted a prospective cohort study of 103 stroke units (SUs) in England. Data of 56,666 patients with stroke admitted between 1 June 2011 and 1 December 2012 were extracted from a national register of stroke care in England. SU characteristics and staffing levels were derived from cross-sectional survey. Cox proportional hazards models were used to estimate hazard ratios (HRs) of 30-d post-admission mortality, adjusting for case mix, organisational, staffing, and care quality variables. After adjusting for confounders, there was no significant difference in mortality risk for patients admitted to a stroke service with stroke specialist physician rounds fewer than 7 d per week (adjusted HR [aHR] 1.04, 95% CI 0.91–1.18) compared to patients admitted to a service with rounds 7 d per week. There was a dose–response relationship between weekend nurse/bed ratios and mortality risk, with the highest risk of death observed in stroke services with the lowest nurse/bed ratios. In multivariable analysis, patients admitted on a weekend to a SU with 1.5 nurses/ten beds had an estimated adjusted 30-d mortality risk of 15.2% (aHR 1.18, 95% CI 1.07–1.29) compared to 11.2% for patients admitted to a unit with 3.0 nurses/ten beds (aHR 0.85, 95% CI 0.77–0.93), equivalent to one excess death per 25 admissions. The main limitation is the risk of confounding from unmeasured characteristics of stroke services.
Conclusions
Mortality outcomes after stroke are associated with the intensity of weekend staffing by registered nurses but not 7-d/wk ward rounds by stroke specialist physicians. The findings have implications for quality improvement and resource allocation in stroke care.
Please see later in the article for the Editors' Summary
Editors' Summary
Background
In a perfect world, a patient admitted to hospital on a weekend or during the night should have as good an outcome as a patient admitted during regular working hours. But several observational studies (investigations that record patient outcomes without intervening in any way; clinical trials, by contrast, test potential healthcare interventions by comparing the outcomes of patients who are deliberately given different treatments) have reported that admission on weekends is associated with a higher mortality (death) rate than admission on weekdays. This “weekend effect” has led to calls for increased medical and nursing staff to be available in hospitals during the weekend and overnight to ensure that the healthcare provided at these times is of equal quality to that provided during regular working hours. In the UK, for example, “seven-day working” has been identified as a policy and service improvement priority for the National Health Service.
Why Was This Study Done?
Few studies have actually tested the relationship between patient outcomes and weekend physician or nurse staffing levels. It could be that patients who are admitted to hospital on the weekend have poor outcomes because they are generally more ill than those admitted on weekdays. Before any health system introduces potentially expensive increases in weekend staffing levels, better evidence that this intervention will improve patient outcomes is needed. In this prospective cohort study (a study that compares the outcomes of groups of people with different baseline characteristics), the researchers ask whether mortality after stroke is associated with weekend working by stroke specialist physicians and registered nurses. Stroke occurs when the brain's blood supply is interrupted by a blood vessel in the brain bursting (hemorrhagic stroke) or being blocked by a blood clot (ischemic stroke). Swift treatment can limit the damage to the brain caused by stroke, but of the 15 million people who have a stroke every year, about 6 million die within a few hours and another 5 million are left disabled.
What Did the Researchers Do and Find?
The researchers extracted clinical data on 56,666 patients who were admitted to stroke units in England over an 18-month period from a national stroke register. They obtained information on the characteristics and staffing levels of the stroke units from a biennial survey of hospitals admitting patients with stroke, and information on deaths among patients with stroke from the national register of deaths. A quarter of the patients were admitted on a weekend, almost half the stroke units provided stroke specialist physician rounds seven days per week, and the remainder provided rounds five days per week. After adjustment for factors that might have affected outcomes (“confounders”) such as stroke severity and the level of acute stroke care available in each stroke unit, there was no significant difference in mortality risk between patients admitted to a stroke unit with rounds seven days/week and patients admitted to a unit with rounds fewer than seven days/week. However, patients admitted on a weekend to a stroke unit with 1.5 nurses/ten beds had a 30-day mortality risk of 15.2%, whereas patients admitted to a unit with 3.0 nurses/ten beds had a mortality risk of 11.2%, a mortality risk difference equivalent to one excess death per 25 admissions.
What Do These Findings Mean?
These findings show that the provision of stroke specialist physician rounds seven days/week in stroke units in England did not influence the (weak) association between weekend admission for stroke and death recorded in this study, but mortality outcomes after stroke were associated with the intensity of weekend staffing by registered nurses. The accuracy of these findings may be affected by the measure used to judge the level of acute care available in each stroke unit and by residual confounding. For example, patients admitted to units with lower nursing levels may have shared other unknown characteristics that increased their risk of dying after stroke. Moreover, this study considered the impact of staffing levels on mortality only and did not consider other relevant outcomes such as long-term disability. Despite these limitations, these findings support the provision of higher weekend ratios of registered nurses to beds in stroke units, but given the high costs of increasing weekend staffing levels, it is important that controlled trials of different models of physician and nursing staffing are undertaken as soon as possible.
Additional Information
Please access these websites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1001705.
This study is further discussed in a PLOS Medicine Perspective by Meeta Kerlin
Information about plans to introduce seven-day working into the National Health Service in England is available; the 2013 publication “NHS Services—Open Seven Days a Week: Every Day Counts” provides examples of how hospitals across England are working together to provide routine healthcare services seven days a week; a “Behind the Headlines” article on the UK National Health Service Choices website describes a recent observational study that investigated the association between admission to hospital on the weekend and death, and newspaper coverage of the study's results; the Choices website also provides information about stroke for patients and their families, including personal stories
A US nurses' site includes information on the association of nurse staffing with patient safety
The US National Institute of Neurological Disorders and Stroke provides information about all aspects of stroke (in English and Spanish); its Know Stroke site provides educational materials about stroke prevention, treatment, and rehabilitation, including personal stories (in English and Spanish); the US National Institute of Health SeniorHealth website has additional information about stroke
The Internet Stroke Center provides detailed information about stroke for patients, families, and health professionals (in English and Spanish)
doi:10.1371/journal.pmed.1001705
PMCID: PMC4138029  PMID: 25137386
20.  Patent Foramen Ovale in Patients with Sickle Cell Disease and Stroke: Case Presentations and Review of the Literature 
Case Reports in Hematology  2013;2013:516705.
Although individuals with sickle cell disease (SCD) are at increased risk for stroke, the underlying pathophysiology is incompletely understood. Intracardiac shunting via a patent foramen ovale (PFO) is associated with cryptogenic stroke in individuals without SCD. Recent evidence suggests that PFOs are associated with stroke in children with SCD, although the role of PFOs in adults with stroke and SCD is unknown. Here, we report 2 young adults with SCD, stroke, and PFOs. The first patient had hemoglobin SC and presented with a transient ischemic attack and a subsequent ischemic stroke. There was no evidence of cerebral vascular disease on imaging studies and the PFO was closed. The second patient had hemoglobin SS and two acute ischemic strokes. She had cerebral vascular disease with moyamoya in addition to a peripheral deep venous thrombosis (DVT). Chronic transfusion therapy was recommended, and the DVT was managed with warfarin. The PFO was not closed, and the patients' neurologic symptoms were stabilized. We review the literature on PFOs and stroke in SCD. Our cases and the literature review illustrate the dire need for further research to evaluate PFO as a potential risk factor for stroke in adults with SCD.
doi:10.1155/2013/516705
PMCID: PMC3730376  PMID: 23956892
21.  Prevalence of Intracardiac Shunting in Children with Sickle Cell Disease and Stroke 
The Journal of pediatrics  2009;156(4):645-650.
Objective
To determine the prevalence of potential intracardiac shunts, including patent foramen ovale (PFO), in children with sickle cell disease (SCD) and stroke.
Study design
We performed a transthoracic echocardiogram (TTE) on 40 children with SCD (39 with hemoglobin SS and 1 with sickle-beta0 thalassemia) and earlier stroke (overt stroke in 30, silent infarction in 10). We compared 3 TTE techniques: conventional 2-dimensional imaging, color Doppler ultrasound, and intravenous agitated saline contrast injection for the detection of intracardiac shunts. We also evaluated the clinical, laboratory, and radio-graphic findings of the children with and without shunts.
Results
We identified PFO or other potential intracardiac shunts in 10 of 40 children with SCD and earlier stroke (25%; 95% CI, 11.6-38.4). With contrasted TTE, we failed to detect potential shunts in 2 children. In a comparison group of 60 children with stroke but without SCD, retrospective review of clinical echocardiograms identified PFO in 7 of 60 (11.7%; 95% CI, 3.6-19.8). Clinical features significantly associated with the presence of intracardiac shunts were stroke in the setting of vaso-occlusive crisis (P = .026) and headache at stroke onset (P = .014).
Conclusion
One-quarter of children with SCD and stroke have potential intracardiac shunts. A combination of echocardiographic techniques is required for optimal shunt detection. Intracardiac shunting could be a risk factor for stroke in children with SCD because they are predisposed to thrombosis and elevations of right heart pressure, which could promote paradoxical embolization across an intracardiac shunt.
doi:10.1016/j.jpeds.2009.10.012
PMCID: PMC4250927  PMID: 20022343
22.  Stress Hyperglycaemia in Hospitalised Patients and Their 3-Year Risk of Diabetes: A Scottish Retrospective Cohort Study 
PLoS Medicine  2014;11(8):e1001708.
In a retrospective analysis of a national database of hospital admissions, David McAllister and colleagues identify the 3-year risk of diabetes of hospitalized patients with hyperglycemia in Scotland.
Please see later in the article for the Editors' Summary
Background
Hyperglycaemia during hospital admission is common in patients who are not known to have diabetes and is associated with adverse outcomes. The risk of subsequently developing type 2 diabetes, however, is not known.
We linked a national database of hospital admissions with a national register of diabetes to describe the association between admission glucose and the risk of subsequently developing type 2 diabetes.
Methods and Findings
In a retrospective cohort study, patients aged 30 years or older with an emergency admission to hospital between 2004 and 2008 were included. Prevalent and incident diabetes were identified through the Scottish Care Information (SCI)-Diabetes Collaboration national registry. Patients diagnosed prior to or up to 30 days after hospitalisation were defined as prevalent diabetes and were excluded.
The predicted risk of developing incident type 2 diabetes during the 3 years following hospital discharge by admission glucose, age, and sex was obtained from logistic regression models. We performed separate analyses for patients aged 40 and older, and patients aged 30 to 39 years.
Glucose was measured in 86,634 (71.0%) patients aged 40 and older on admission to hospital. The 3-year risk of developing type 2 diabetes was 2.3% (1,952/86,512) overall, was <1% for a glucose ≤5 mmol/l, and increased to approximately 15% at 15 mmol/l. The risks at 7 mmol/l and 11.1 mmol/l were 2.6% (95% CI 2.5–2.7) and 9.9% (95% CI 9.2–10.6), respectively, with one in four (21,828/86,512) and one in 40 (1,798/86,512) patients having glucose levels above each of these cut-points. For patients aged 30–39, the risks at 7 mmol/l and 11.1 mmol/l were 1.0% (95% CI 0.8–1.3) and 7.8% (95% CI 5.7–10.7), respectively, with one in eight (1,588/11,875) and one in 100 (120/11,875) having glucose levels above each of these cut-points.
The risk of diabetes was also associated with age, sex, and socio-economic deprivation, but not with specialty (medical versus surgical), raised white cell count, or co-morbidity. Similar results were obtained for pre-specified sub-groups admitted with myocardial infarction, chronic obstructive pulmonary disease, and stroke.
There were 25,193 deaths (85.8 per 1,000 person-years) over 297,122 person-years, of which 2,406 (8.1 per 1,000 person-years) were attributed to vascular disease. Patients with glucose levels of 11.1 to 15 mmol/l and >15 mmol/l had higher mortality than patients with a glucose of <6.1 mmol/l (hazard ratio 1.54; 95% CI 1.42–1.68 and 2.50; 95% CI 2.14–2.95, respectively) in models adjusting for age and sex.
Limitations of our study include that we did not have data on ethnicity or body mass index, which may have improved prediction and the results have not been validated in non-white populations or populations outside of Scotland.
Conclusion
Plasma glucose measured during an emergency hospital admission predicts subsequent risk of developing type 2 diabetes. Mortality was also 1.5-fold higher in patients with elevated glucose levels. Our findings can be used to inform patients of their long-term risk of type 2 diabetes, and to target lifestyle advice to those patients at highest risk.
Please see later in the article for the Editors' Summary
Editors' Summary
Background
Insulin—a hormone released by the pancreas after meals—controls blood glucose (sugar) levels in healthy individuals. However, many patients admitted to hospital because of an acute illness have hyperglycemia, an abnormally high blood glucose level. In this setting, hyperglycemia can be caused by the drugs that patients are taking for existing conditions or may be stress hyperglycemia, a reversible condition in which hormonal changes induced by acute illness stimulate glucose production by the liver. However, hyperglycemia detected during an acute illness may also indicate underlying or incipient type 2 diabetes, a common condition in which blood glucose control fails. Type 2 diabetes can initially be controlled by diet, exercise, and antidiabetic drugs but many patients eventually need insulin injections to control their blood sugar level. Long-term complications of type 2 diabetes, which include an increased risk of heart attacks and stroke, reduce the life expectancy of people with diabetes by about 10 years compared to people without diabetes
Why Was This Study Done?
Prompt diagnosis of type 2 diabetes can minimize its long-term complications, so experts have designed several scoring systems based on lifestyle and other characteristics that allow primary care clinicians to identify the patients who should be tested for diabetes because they are at high risk of developing the condition. Unfortunately, these scoring systems cannot be used to interpret a high blood glucose result obtained during an acute illness so clinicians cannot currently advise their patients on the clinical significance of this type of abnormal glucose reading or make an informed decision about whether follow-up testing is needed. In this retrospective cohort study, the researchers investigate the association between blood glucose levels measured during emergency hospital admissions in Scotland and the risk of developing type 2 diabetes by linking together national databases of hospital admissions, laboratory test results, and people with diabetes. A retrospective cohort study examines the medical histories of a group of patients.
What Did the Researchers Do and Find?
The researchers used the databases to identify more than 100,000 patients aged 30 years or older who were admitted to a hospital for an acute illness between 2004 and 2008 in Scotland, to obtain information on blood glucose levels on admission for nearly three-quarters of these patients, and to identify which patients subsequently developed diabetes. They then used statistical models to estimate the patients' risk of developing type 2 diabetes during the 3 years following hospital discharge. Among patients aged 40 years or older, the overall 3-year risk of developing diabetes was 2.3%. The risk of developing diabetes increased linearly with increasing blood glucose level at admission. Specifically, the 3-year risks at blood glucose levels of 7 mmol/l and 11.1 mmol/l were 2.6% and 9.9%, respectively; because glucose levels fluctuate according to when an individual last ate, fasting blood glucose levels of 7 mmol/l and non-fasting blood glucose levels of 11.1 mmol/l are used as thresholds for the diagnosis of diabetes. The diabetes risk associated with blood glucose levels on admission among 30–39-year-old patients followed a similar pattern but was less marked. Finally, high glucose levels on admission were associated with increased mortality.
What Do These Findings Mean?
These findings indicate that blood glucose measured during an emergency hospital admission predicts the subsequent risk of type 2 diabetes among patients aged 40 years or older (the analysis specified in the researchers' original protocol). Importantly, however, they also suggest that a high blood glucose reading in these circumstances usually indicates stress hyperglycemia rather than type 2 diabetes. The accuracy and generalizability of these findings may be limited by the lack of data on ethnicity or body mass index (a measure of obesity), both of which affect diabetes risk, and by other aspects of the study design. Nevertheless, given their findings, the researchers recommend that any patient with a blood glucose level above 11.1 mmol/l on hospital admission for an acute illness (one in 40 patients in this study) should be offered follow-up testing. In addition, the researchers constructed a risk calculator using their findings that should help clinicians to inform their patients about their long-term risk of diabetes following hyperglycemia during an acute hospital admission and to target lifestyle advice to those patients at the highest risk of type 2 diabetes.
Additional Information
Please access these websites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1001708.
The US National Diabetes Information Clearinghouse provides information about diabetes and about diabetes prevention (in English and Spanish)
The UK National Health Service Choices website provides information about type 2 diabetes and about living with diabetes; it also provides people's stories about diabetes
The charity Diabetes UK provides information about diabetes in several languages, including information on healthy lifestyles for people with diabetes
Wikipedia has a page on stress hyperglycemia (note that Wikipedia is a free online encyclopedia that anyone can edit; available in several languages)
More information about stress hyperglycemia is available in Diapedia, a living textbook of diabetes produced by the European Association for the Study of Diabetes
GUARD (Glucose on Unselected Admissions and Risk of Diabetes), a risk calculator that allows clinicians to estimate a patient's 3-year risk of diabetes following hyperglycemia at hospital admission for an acute illness, is available online
The UK-based non-profit organization Healthtalkonline has interviews with people about their experiences of diabetes
MedlinePlus provides links to further resources and advice about diabetes and diabetes prevention (in English and Spanish)
doi:10.1371/journal.pmed.1001708
PMCID: PMC4138030  PMID: 25136809
23.  Blood Transfusion in Patients with Sickle Cell Disease Requiring Laparoscopic Cholecystectomy 
Laparoscopic cholecystectomy in patients with sickle cell disease was found to be safe without preoperative blood transfusion.
Background:
Surgery in patients with sickle cell disease is associated with high morbidity. To reduce this high morbidity, different preoperative transfusion regimens were introduced. However, blood transfusion is associated with problems. This prospective study aims to establish the safety of conducting laparoscopic cholecystectomy without transfusion in sickle cell disease patients.
Methods:
Forty patients (16 males and 24 females; mean age 26.6 years) undergoing laparoscopic cholecystectomy for cholelithiasis were divided into 2 matched groups: Group I “no transfusion” (n=24 patients; 60%) and Group II “transfusion” (n=16; 40%). In Group II, 9 patients (22.5%) received a simple transfusion and 7 (17.5%) a partial exchange transfusion.
Results:
Group II patients had significantly higher levels of Hb-S prior to transfusion. They developed a significantly higher complication rate (25% vs. 0%) and subsequently longer hospital stay (3.9±2 vs. 2.1±1.4). Moreover, there was no significant difference in the complications between the simple transfusion and partial exchange transfusion subgroups.
Conclusion:
Surgery in SCD patients is safe without a preoperative blood transfusion. Moreover, preoperative blood transfusion is associated with significantly higher postoperative complications and longer hospital stay. Hence, a “no transfusion” policy is recommended.
doi:10.4293/108680811X13176785203996
PMCID: PMC3340956  PMID: 22643502
Sickle cell disease; Surgery; Postoperative complications; Blood transfusion
24.  Red Blood Cell Storage Duration is Not Associated with Clinical Outcomes for Acute Chest Syndrome in Children with Sickle Cell Disease 
Transfusion  2015;55(11):2714-2721.
Background
Providers commonly transfuse sickle cell disease (SCD) patients with fresh red blood cells (RBCs) as treatment for acute chest syndrome (ACS). The objective of this study is to determine if there is an association between the storage duration of RBCs and length of hospitalization and oxygen requirement after transfusion in pediatric SCD patients with ACS.
Study Design and Methods
This is a retrospective cohort study of pediatric SCD patients with ACS treated with a simple RBC transfusion over 8.5 years at a single institution. Multivariate generalized estimation equation analysis was used to identify associations between storage duration of RBCs and outcome measures.
Results
Two hundred thirty-four ACS episodes in 131 subjects were included. The median storage duration of the oldest unit of transfused RBCs was 17 days (IQR 11 – 26). The majority of ACS episodes, 77.4% were treated with 1 unit of transfused RBCs, 20.9% received 2 units and 1.7% received 3 or more units of RBCs. There was no association between the storage duration of the oldest unit of transfused RBCs, and either duration of hospitalization or supplemental oxygen requirement after transfusion in multivariate analyses.
Conclusion
This retrospective study is one of the first to investigate the role of the storage lesion in children with SCD, and does not support the preferential transfusion of fresh RBCs for ACS. Ultimately, a randomized controlled trial (RCT) is necessary to determine whether the storage age of RBCs affects outcomes for patients with SCD and ACS.
doi:10.1111/trf.13176
PMCID: PMC4644117  PMID: 26033266
Sickle cell disease; sickle cell anemia; acute chest syndrome; storage lesion; transfusion
25.  Sickle cell disease 
BMJ Clinical Evidence  2009;2009:2402.
Introduction
Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises, and increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1-2% of babies are born with the disease.
Methods and outcomes
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of pharmaceutical and non-pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? What are the effects of pharmaceutical and non-pharmaceutical interventions to treat pain in people with sickle cell crisis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2007 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results
We found 38 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions
In this systematic review we present information relating to the effectiveness and safety of the following interventions: acupuncture, antibiotic prophylaxis in children under 5 years of age, aspirin, avoidance of cold environment, blood transfusion, codeine, corticosteroid (with narcotic analgesics), diflunisal, hydration, hydroxyurea, ibuprofen, ketorolac, limiting physical exercise, malaria chemoprophylaxis, morphine (controlled-release oral after initial intravenous bolus, repeated intravenous doses), oxygen, paracetamol, patient-controlled analgesia, penicillin prophylaxis in children over 5 years of age, piracetam, pneumococcal vaccines, rehydration, and zinc sulphate.
Key Points
In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1-2% of babies are born with the disease. Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises, and increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion.
We don’t know whether avoidance of cold environments, physical exercise, or dehydration can prevent crises or complications in people with sickle cell disease. Penicillin prophylaxis in children under 5 years of age reduces invasive pneumococcal infections regardless of pneumococcal vaccination status. We don’t know whether penicillin prophylaxis is beneficial in older children. Malaria chemoprophylaxis is considered useful in preventing malaria-induced crises, but we found few studies evaluating its benefit.
Hydroxyurea, piracetam, and zinc sulphate may reduce some complications of sickle cell disease, such as painful crises, compared with placebo, but their long-term effects and safety are unknown.
Morphine is widely used to treat severe pain, but we found no RCT evidence comparing it with placebo in people with sickle cell crises. Controlled-release oral morphine and patient-controlled analgesia may be as effective as repeated intravenous doses of morphine. Oral morphine increases the risk of acute chest syndrome compared with intravenous administration.High-dose corticosteroids may reduce the need for analgesia when added to intravenous morphine in people with a sickle cell crisis, but may increase the risks of adverse effects such as infections, hypertension, and metabolic problems.
It is still unclear whether acupuncture, blood transfusion, hydration, oxygen, aspirin, codeine, diflunisal, ibuprofen, ketorolac, or paracetamol reduce pain during sickle cell crisis.
PMCID: PMC2907800  PMID: 19445751

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