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1.  (E)-N′-(5-Bromo-2-hy­droxy­benzyl­idene)-2-(4-isobutyl­phen­yl)propano­hydrazide 
The title compound, C20H23BrN2O2, containing an ibuprofen core, crystallizes with three independent mol­ecules of similar conformation in the asymmetric unit. In these three mol­ecules, the two benzene rings make dihedral angles of 82.7 (2), 71.2 (2) and 78.0 (3)° with respect to each other. The atoms of the isobutyl groups in two of the mol­ecules are disordered over two positions, with site-occupancy ratios of 0.516 (8):0.484 (8) and 0.580 (8):0.420 (8). In the crystal, mol­ecules are linked by N—H⋯O, C—H⋯O and O—H⋯N hydrogen bonds. Furthermore, C—H⋯π inter­actions are also observed.
doi:10.1107/S1600536812030322
PMCID: PMC3414297  PMID: 22904830
2.  (E)-N′-(2-Hydroxy­benzyl­idene)-2-(4-isobutyl­phen­yl)propanohydrazide 
The title hydrazide compound, C20H24N2O2, exists in a trans configuration with respect to the acyclic C=N bond and an intra­molecular O—H⋯N hydrogen bond generates an S(6) ring motif. The mean plane through the formohydrazide unit is essentially planar [maximum deviation = 0.025 (2) Å], and forms dihedral angles of 24.45 (16) and 87.14 (16)° with the two benzene rings. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link neighbouring mol­ecules into extended chains along the c axis, which incorporate R 2 2(16) ring motifs. An inter­molecular C—H⋯π inter­action is also observed.
doi:10.1107/S1600536809050971
PMCID: PMC2980184  PMID: 21580121
3.  (2E)-2-Hydroxy­imino-N′-[(E)-2-pyridyl­methyl­ene]propanohydrazide 
In the title compound, C9H10N4O2, the pyridine ring is twisted by 16.5 (1)° from the mean plane defined by the remaining non-H atoms. An intra­molecular N—H⋯N inter­action is present. In the crystal, inter­molecular O—H⋯N and N—H⋯O hydrogen bonds link mol­ecules into layers parallel to the bc plane. The crystal packing exhibits π–π inter­actions indicated by the short distance of 3.649 (1) Å between the centroids of the pyridine rings of neighbouring mol­ecules.
doi:10.1107/S1600536809034400
PMCID: PMC2970200  PMID: 21577872
4.  2,4-Dichloro-6-({2-[(3,5-dichloro-2-hy­droxy­benzyl­idene)amino]­eth­yl}imino­meth­yl)phenol 
The title mol­ecule, C16H12Cl4N2O2, lies about an inversion center. The symmetry-unique part of the mol­ecule contains an intra­molecular O—H⋯N hydrogen bond. In the crystal, mol­ecules are arranged in corrugated layers parallel to (-101). Weak π–π stacking inter­actions, with a centroid–centroid diatance of 3.7923 (13) Å, are present.
doi:10.1107/S1600536812020235
PMCID: PMC3379294  PMID: 22719492
5.  (E)-N′-(5-Bromo-2-hy­droxy­benzyl­idene)-3,5-dihy­droxy­benzohydrazide monohydrate 
The Schiff base mol­ecule in the title compound, C14H11BrN2O4·H2O, is almost planar with an r.m.s. deviation for the non-H atoms of 0.16 Å. In the crystal structure, the Schiff base mol­ecules and the water mol­ecules are linked together by inter­molecular N—H⋯O and O—H⋯O hydrogen bonds, leading to layers parallel to the bc plane. An intra­molecular O—H⋯N hydrogen bond involving the imine N atom and a hy­droxy substituent is also observed.
doi:10.1107/S1600536810027856
PMCID: PMC3007438  PMID: 21588352
6.  2-Hydroxy­imino-N′-[1-(2-pyrid­yl)ethyl­idene]propanohydrazide 
The title compound, C10H12N4O2, features an intra­molecular N—H⋯N hydrogen bond formed between the imine NH and oxime N atoms. The oxime group and the amide C=O bond are anti to each other. In the crystal, mol­ecules are connected by O—H⋯O hydrogen bonds into supra­molecular zigzag chains along the c axis.
doi:10.1107/S1600536809033352
PMCID: PMC2969988  PMID: 21577640
7.  Dichlorido{2-hydroxy­imino-N′-[1-(2-pyrid­yl)ethyl­idene]propanohydrazide-κ3 N,N′,O}zinc(II) hemihydrate 
The title compound, [ZnCl2(C10H12N4O2)]·0.5H2O, was readily prepared by the reaction between ZnCl2 and 2-hydroxy­imino-N′-[1-(2-pyrid­yl)ethyl­idene]propanohydrazide. The Zn atom has a distorted trigonal–bipyramidal geometry with two Cl atoms and one azomethine N atom in the equatorial plane and one pyridine N atom and one amide O atom in the axial positions. In the crystal structure, complex mol­ecules are connected in pairs by N—H⋯Cl hydrogen bonds, formed between the amide NH of one mol­ecule and the Cl atom of a neighboring one. Mol­ecular pairs are connected by hydrogen bonds involving the uncoordinated water mol­ecule, which lies on a twofold axis.
doi:10.1107/S160053680706535X
PMCID: PMC2960173  PMID: 21201313
8.  3-Chloro-N′-(4-hy­droxy­benzyl­idene)benzohydrazide 
The title compound, C14H11ClN2O2, was prepared by the reaction of 4-hy­droxy­benzaldehyde with 3-chloro­benzo­hydrazide in methanol. The dihedral angle between the two benzene rings is 38.2 (2)°. In the crystal, mol­ecules are linked through inter­molecular N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming layers lying parallel to the bc plane.
doi:10.1107/S1600536811000699
PMCID: PMC3051464  PMID: 21523015
9.  3-Chloro-N′-(3-eth­oxy-2-hy­droxy­benzyl­idene)benzohydrazide monohydrate 
In the title compound, C16H15ClN2O3·H2O, the water mol­ecule is linked to the Schiff base mol­ecule via an O—H⋯O hydrogen bond. In the Schiff base mol­ecule, an intramolecular O—H⋯N hydrogen bond occurs and the dihedral angle between the two benzene rings is 20.5 (5)°. In the crystal, the Schiff base and water mol­ecules are linked by inter­molecular N—H⋯O and O—H⋯O hydrogen bonds, forming layers in the ab plane.
doi:10.1107/S160053681100122X
PMCID: PMC3051784  PMID: 21523054
10.  (E)-N′-(5-Bromo-2-hy­droxy­benzyl­idene)-3-methyl­benzohydrazide 
In the title mol­ecule, C15H13BrN2O2, an intra­molecular O—H⋯N hydrogen bond influences the mol­ecular conformation; the two benzene rings form a dihedral angle of 13.6 (3)°. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains along the a axis and weak inter­molecular C—H⋯O hydrogen bonds further link these chains into layers parallel to the ac plane.
doi:10.1107/S1600536811025426
PMCID: PMC3212273  PMID: 22090930
11.  Ethyl (2E)-2-(hydroxy­imino)propanoate 
The mol­ecule of the title compound, C5H9NO3, is essentially planar [the maximum deviation for a non-H atom from the mean plane is 0.021 (3) Å] due to the π-conjugation of the hydroxy­imino and carbonyl groups, which are trans to each other; ab initio calculations in vacuo at the DFT (B3LYP/6–311G**++) level of theory confirmed that E conformer is indeed the lowest in energy. The packing in crystal structure is influenced by strong inter­molecular O—H⋯N hydrogen-bonding inter­actions between oxime groups and also by π-stacking of the mol­ecules due to the carbonyl and oxime group orbital overlap [inter­planar distance between adjacent mol­ecules = 3.143 (4) Å]. Jointly, these factors afford infinite 6.32 Å thick mol­ecular sheets, where the plane of each mol­ecule is perpendicular to the plane of the sheet. Seen from above, the mol­ecules within the sheet are arranged in a herringbone pattern. Such sheets form a stack due to weak van der Waals inter­actions; the gap between adjacent sheets is 2.07 Å.
doi:10.1107/S1600536810009438
PMCID: PMC2983986  PMID: 21580705
12.  4,6-Dichloro-2-{[(E)-(3-{[(E)-3,5-dichloro-2-hy­droxy­benzyl­idene]amino}-2,2-dimethyl­prop­yl)imino]­meth­yl}phenol 
In the title compound, C19H18Cl4N2O2, a potential tetra­dentate Schiff base ligand, the dihedral angle between the two benzene rings is 48.01 (10)°. The configuration about the two C=N bonds is E and two intra­molecular O—H⋯N hydrogen bonds make S(6) ring motifs. In the crystal, mol­ecules are linked along the b axis via inter­molecular C—H⋯Cl inter­actions. The crystal structure is further stabilized by an inter­molecular π–π inter­action [centroid–centroid distance = 3.5744 (12) Å].
doi:10.1107/S1600536811053438
PMCID: PMC3254485  PMID: 22259428
13.  4,6-Dibromo-2-[(E)-(4-{[(E)-3,5-dibromo-2-hy­droxy­benzyl­idene]amino}­butyl)­imino­meth­yl]phenol 
The asymmetric unit of the title compound, C18H16Br4N2O2, comprises half the molecule, which is located adjacent to an inversion centre at the mid-point of the central C—C bond of the butane-1,4-diamine segment. There are two intra­molecular O—H⋯N hydrogen bonds making S(6) ring motifs. In the crystal, mol­ecules are linked by pairs of weak C—H⋯Br inter­actions into chains along [101], which include R 2 2(8) ring motifs. These chains are further linked by C—H⋯O hydrogen bonds, forming a three-dimensional network.
doi:10.1107/S1600536812028863
PMCID: PMC3394053  PMID: 22798918
14.  N′-[(E)-4-Benz­yloxy-2-hy­droxy­benzyl­idene]-4-nitro­benzohydrazide di­methyl­formamide monosolvate 
The title compound, C21H17N3O5·C3H7NO, exists in an E conformation with respect to the azomethine double bond of the hydrazide mol­ecule. This mol­ecule contains an intra­molecular O—H⋯N hydrogen bond, while an inter­molecular N—H⋯O hydrogen bond links the hydrazide to the formamide mol­ecule of solvation. Nonclassical C—H⋯O inter­molecular hydrogen bonds build up a supra­molecular architecture, together with two C—H⋯π inter­actions and a weak π–π inter­action, with a centroid–centroid distance of 3.650 (13) Å.
doi:10.1107/S1600536813017091
PMCID: PMC3770421  PMID: 24046706
15.  4-Bromo-2-[(E)-(2-{2-[(2-{[(E)-5-bromo-2-hy­droxy­benzyl­idene]amino}­phen­yl)sulfan­yl]ethyl­sulfan­yl}phen­yl)imino­meth­yl]phenol 
The asymmetric unit of the title compound, C28H22Br2N2O2S2, comprises half of a Schiff base ligand, the whole mol­ecule being generated by a crystallographic inversion center located at the mid-point of the C—C bond of the central methyl­ene segment. Intra­molecular O—H⋯N and O—H⋯S hydrogen bonds make S(6) and S(5) ring motifs, respectively. In the crystal, there are no significant inter­molecular inter­actions.
doi:10.1107/S1600536812034071
PMCID: PMC3435662  PMID: 22969535
16.  N′-(4-Hy­droxy­benzyl­idene)-4-nitro­benzohydrazide 
The title compound, C14H11N3O4, was prepared by the reaction of 4-nitro­benzohydrazide with 4-hy­droxy­benz­alde­hyde. The whole mol­ecule of the compound is approximately planar, with a mean deviation from the least-squares plane through all the non-H atoms of 0.050 (2) Å; the dihedral angle between the two benzene rings is 2.0 (2)°. In the crystal, the benzohydrazide mol­ecules are linked through inter­molecular O—H⋯O and N—H⋯O hydrogen bonds, forming layers in the bc plane.
doi:10.1107/S1600536810042364
PMCID: PMC3009258  PMID: 21589112
17.  N′-(3-Hy­droxy­benzyl­idene)-4-nitro­benzohydrazide 
The title mol­ecule, C14H11N3O4, is approximately planar, with an inter­planar angle between the two benzene rings of 5.8 (2)°. In the crystal, four mol­ecules are linked by an R 4 4(12) motif with pairs of strong O—H⋯O and N—H⋯O hydrogen bonds. The motif is situated about the crystallographic centres of symmetry and it is composed of two pairs of parallel mol­ecules. This quadruplet of mol­ecules is further extended by symmetry-equivalent hydrogen bonds to form layers parallel to the (10) plane. In addition to the hydrogen bonds, there is also a weak π–π inter­action between the benzene rings.
doi:10.1107/S1600536810043564
PMCID: PMC3009013  PMID: 21589165
18.  N′-(5-Bromo-2-hy­droxy­benzyl­idene)-4-nitro­benzohydrazide methanol monosolvate 
In the title compound, C14H10BrN3O4·CH4O, the benzohydrazide mol­ecule is nearly planar [maximum deviation = 0.110 (2) Å]. The mean planes of the two benzene rings make a dihedral angle of 8.4 (3)°. In the benzohydrazide mol­ecule, there is an intra­molecular O—H⋯N hydrogen bond and the NH group is hydrogen bonded to the methanol solvent mol­ecule. In the crystal, inter­molecular O—H⋯O hydrogen bonds involving the methanol solvent mol­ecule link the benzohydrazide mol­ecules to form chains which propagate along the a axis.
doi:10.1107/S1600536811030108
PMCID: PMC3213628  PMID: 22091205
19.  Benzyl N-(2-hy­droxy-1-{N′-[(1E)-2-hy­droxy­benzyl­idene]hydrazinecarbon­yl}eth­yl)carbamate 
The mol­ecule of the title compound, C18H19N3O5, adopts a curved arrangement with the terminal benzene rings lying to the same side. The hydroxyl­benzene ring is close to coplanar with the adjacent hydrazine residue [dihedral angle = 11.14 (12)°], an observation which correlates with the presence of an intra­molecular O—H⋯N hydrogen bond. The benzyl ring forms a dihedral angle of 50.84 (13)° with the adjacent carbamate group. A twist in the mol­ecule, at the chiral C atom, is reflected in the dihedral angle of 80.21 (12)° formed between the amide residues. In the crystal, two-dimensional arrays in the ac plane are mediated by O—H⋯O and N—H⋯O hydrogen bonds.
doi:10.1107/S1600536811025128
PMCID: PMC3151747  PMID: 21837230
20.  7-[(3,5-Di-tert-butyl-2-hy­droxy­benzyl­idene)amino]-4-methyl-2H-chromen-2-one 
The title compound, C25H29NO3, is a Schiff base derivative of coumarin 120. There are two structurally similar but crystallographically independent mol­ecules in the asymmetric unit. Both mol­ecules exist in E configurations with respect to the C=N double bonds. The dihedral angles between the coumarin and 3,5-di-tert-butyl-2-hy­droxy­benzyl­idene ring planes are 4.62 (7) and 14.62 (7)° for the two mol­ecules. Intra­molecular O—H⋯N hydrogen bonding involving the O—H groups and the azomethine N atoms generate S(6) rings. In the crystal structure, independent mol­ecules are linked by C—H⋯π inter­actions, with groups of four mol­ecules stacked along the c axis.
doi:10.1107/S1600536810036743
PMCID: PMC2983148  PMID: 21587568
21.  N′-(3,5-Dibromo-2-hy­droxy­benzyl­idene)-4-nitro­benzohydrazide methanol monosolvate 
The title compound, C14H9Br2N3O4·CH4O, was obtained as the product of the reaction of 3,5-dibromo­salicyl­aldehyde with 4-nitro­benzohydrazide in methanol. The benzohydrazide mol­ecule is nearly planar, with a maximum deviation of 0.126 (2) Å. The mean planes of the two benzene rings make a dihedral angle of 9.3 (3)°. Intra­molecular O—H⋯N and O—H⋯Br inter­actions are observed in the benzohydrazide mol­ecule. In the crystal, pairs of adjacent benzohydrazide mol­ecules are linked by two methanol mol­ecules through inter­molecular O—H⋯O and N—H⋯O hydrogen bonds, forming a dimer.
doi:10.1107/S1600536811031187
PMCID: PMC3200651  PMID: 22065140
22.  N′-(3-Hy­droxy­benzyl­idene)-4-methyl­benzohydrazide 
The title compound, C15H14N2O2, was obtained from the reaction of 3-hy­droxy­benzaldhyde and 4-methyl­benzo­hydrazide in methanol. In the mol­ecule, the benzene rings form a dihedral angle of 2.9 (3)°. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds link the mol­ecules into layers parallel to (101). The crystal packing also exhibits π–π inter­actions between the aromatic rings [centroid–centroid distance = 3.686 (4) Å].
doi:10.1107/S1600536812021897
PMCID: PMC3379390  PMID: 22719588
23.  N′-(3-Eth­oxy-2-hy­droxy­benzyl­idene)-2-hy­droxy-3-methyl­benzohydrazide 
The title compound, C17H18N2O4, crystallizes with two independent mol­ecules in the asymmetric unit. The two benzene rings in each mol­ecule make dihedral angles of 7.6 (3) and 3.9 (3)°. Intra­molecular O—H⋯N and O—H⋯O hydrogen bonds are present in each mol­ecule. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules into chains propagating in [010]. The are also a number of C—H⋯O and π–π inter­actions present [centroid–centroid distances = 3.874 (4) and 3.904 (3) Å], that result in the formation of a three-dimensional network.
doi:10.1107/S1600536812002127
PMCID: PMC3275245  PMID: 22347101
24.  2-[(E)-4-Diethyl­amino-2-hy­droxy­benzyl­idene]hydrazinecarboxamide 
Two mol­ecules make up the asymmetric unit of the title compound, C12H18N4O2, and both feature an intra­molecular O—H⋯N hydrogen bond, which generates an S(6) ring. The diethyl­amino group of one of the mol­ecules is disordered over two sets of sites in a 0.59 (2):0.41 (2) ratio. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules into sheets lying parallel to the ac plane and C—H⋯π inter­actions are also observed.
doi:10.1107/S1600536812000311
PMCID: PMC3275058  PMID: 22347003
25.  (E)-4-Amino-N′-(5-chloro-2-hy­droxy­benzyl­idene)benzohydrazide 
In the title hydrazide Schiff base compound, C14H12ClN3O2, the conformation around the C=N double bond is E. The dihedral angle between the benzene rings is 41.57 (14) Å. An intra­molecular O—H⋯N hydrogen bond makes an S(6) ring motif. In the crystal, mol­ecules are linked by N—H⋯O (bifurcated acceptor) and N—H⋯N hydrogen bonds, forming chains along the a axis. The inter­esting feature of the crystal structure is the short inter­molecular C⋯O [3.216 (3), 3.170 (3), and 2.992 (3) Å] contacts, one of which is significantly shorter than the sum of the van der Waals radii of these atoms [3.22 Å].
doi:10.1107/S1600536812025974
PMCID: PMC3393930  PMID: 22798795

Results 1-25 (192220)