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1.  PA03.04. Clinical study of trikatu thaila nasya in the management of kaphaja sirasoola (maxillary sinusitis) 
Ancient Science of Life  2013;32(Suppl 2):S73.
Purpose:
Kaphaja Shiras Shoola is one among the types of Shirorogas. It can be correlated to the diseases of maxillary sinusitis. It is one of the commonly found diseases in day to day clinical practice. The symptoms of Kaphaja Shiras Shoola include mild / moderate head ache, heaviness of head, nasal discharge and nasal obstruction. Objectives of the present study were to get a solution to kaphaja sirasoola by evaluating the efficacy of trikatu thaila nasya in the management of kaphaja sirasoola.
Method:
20 patients fulfilling the inclusion criteria of Kaphaja Sirasoola were randomly selected from the OPD and IPD of S.D.M College of Ayurveda & Hospital, Hassan. Nasya was given with 8 drops of medicine in each nostril early in the morning on empty stomach for seven days. Follow up was done for the period of 2 months. Clinical sign and symptoms were given on the basis of self formulated scoring scale. The result having ‘p’ value less than <0.05 were considered as statistically significant in this study.
Result:
Overall effect of therapies after the course of treatment showed complete remission in 10%, marked improvement in 74%, moderate improvement in 11 % and mild relief in 5 % of patients.
Conclusion:
Trikatu thaila nasya has significant effect in the management of kaphaja sirasoola. Reduction in clinical symptoms was appreciated after nasya is proved statistically significant.
doi:10.4103/0257-7941.123896
PMCID: PMC4147547
2.  OA01.44. Efficacy of arjunatwak mukhalepa and panchanimba churna in the management of vyanga w.s.r.to facial melanosis 
Ancient Science of Life  2012;32(Suppl 1):S44.
Purpose:
The smooth and glowing complexion of face increases the beauty of a person and also gives tremendous self-confidence. Vyanga is a disease which decreases the glowing complexion of face and affects the skin. Even though it is considered as kshudra roga (minor disease), it has got a major importance as a cosmetic problem in the society. It is characterized by the presence of painless and bluish-black patches on face. Treating this condition has become a problem, since safe drugs are not available for long term therapy. So the study was aimed to evaluate the efficacy of Arjunatwak lepa with Madhu and Panchanimba churna internally.
Method:
For clinical study, 30 clinically diagnosed patients were registered and divided into two groups with 15 patients in each group. In Group-A patients were administered with Arjunatwak lepa with Madhu for 21days. In Group-B patients were administered with both Arjunatwak lepa with Madhu and Panchanimba churna internally for 21days
Result:
In Group A, out of 15 patients, 09 patients were cured completely, which was statistically significant at the level of p<0.01. 4 patients have shown marked improvement, 2 patients showed slight improvement. In Group B, out of 15 patients, 12 patients had attained normal skin color, which was statistically highly significant at the level of p<0.001, 1 patient had mild improvement, 2 patients have moderate improvement. Statistically significant result was obtained in symptom bluish-black patch over the face. The clinical study has shown that combined therapy in Group-B gives better results than topical treatment.
Conclusion:
From the observations and results of this study, it can be concluded that combined therapy using Arjunatwak lepa along with Panchanimba churna have provided better results in depigmentation of the patches seen in Vyanga roga than local therapy.
PMCID: PMC3800923
3.  A clinical study on Akshitarpana and combination of Akshitarpana with Nasya therapy in Timira with special reference to myopia 
Ayu  2010;31(4):473-477.
Myopia, commonly referred to as shortsightedness, is the most common eye disease in the world with substantial social, educational, and economic impact. Some of the clinical features of Timira can be correlated with myopia. An open randomized clinical trial was conducted to evaluate the role of Tarpana with and without Nasya in patients suffering from myopia. In total, 41 patients were registered in two groups, out of which 30 patients completed the treatment. In Group A, Tarpana with Mahatriphaladya Ghrita and in Group B, Nasya with Abhijita taila followed by Tarpana with Mahatriphaladya Ghrita was administered. After enrollment of the patients in the study, the cardinal signs and symptoms of Timira — myopia, that is, visual acuity, clinical refraction, were evaluated before and after the treatment. Comparatively, more relief in the signs and symptoms were found in the Nasya group followed by the Tarpana group.
doi:10.4103/0974-8520.82045
PMCID: PMC3202262  PMID: 22048542
Timira; Myopia; Mahatriphaladya Ghrita; Abhijit Taila; Tarpana; Nasya
4.  OA01.12. A clinical study of efficacy of Vyoshadi gutika and Pippalayadi churna avapida nasya in the management of Pratishyaya 
Ancient Science of Life  2012;32(Suppl 1):S12.
Purpose:
Pratishyay basically is a Vat-kaphaj disorder arising from accumulation of vitiated Vat along with kaph-pitta-rakta in uttamang (shirh pradesh) and comparable to Rhinitis which describes a group of symptoms including runny nose, stuffiness, sneezing usually due to common cold, environmental irritants and immunodeficiency. This study aim to do 1. Evaluation of effectiveness of Vyoshadi gutika (samshaman therapy) and Pippalayadi churna Avapida nasya (samshodhan therapy) in the management of pratishyay, 2. Statistical assessment of data post treatment.
Method:
60 patients of Pratishyay aged between 16-60 years of age of both sexes complaining of Rhinorrhoea/ nasal block, sneezing, heaviness of head, anosmia were selected randomly and assigned for clinical study were divided into 2 groups. Group A consisting of 30 patients had internal administration of Vyoshadi gutika in a dose of 2 tablets QID (each tab. 375 mg) with lukewarm water for 30 days. Group B-30 patients took Vyoshadi gutika along with Pippalayadi churna Avapida nasya (6 drops in each nostril early morning) for duration of 21 days. All patients were advised to attend 15 days Intercal regularly for 3 months for assessment of disease through subjective and objective parameters.
Result:
60% patients (18 no.) of Group B while 47% patients (14 no.) Group A responded satisfactorily with maximum improvement (more than 76% symptomatic improvement). Similarly, Moderate improvement (between 51-75%) was seen in 47 patients of Group A and 37% of Group B while mild improvement in 10% and 3% patients of Group A and B respectively. No untoward adverse effects were seen in any patients.
Conclusion:
It can be concluded that on the basis of Practical, Therapeutic and Statistical analysis, patients of both groups got satisfactory improvement. Besides, patients treated with both Samshodhan Nasya therapy and Samshaman Vyoshadi Gutika therapy comparatively got better results.
PMCID: PMC3800874
5.  Endoscopic evaluation of therapeutic effects of “Anuloma-Viloma Pranayama” in Pratishyaya w.s.r. to mucociliary clearance mechanism and Bernoulli's principle 
Ayu  2013;34(4):361-367.
The current endeavor intended to evaluate the effectiveness and mode of action of Anuloma-Viloma Pranayama (AVP), i.e., alternate nasal breathing exercise, in resolving clinical features of Pratishyaya, i.e., rhinosinusitis. The present study was directed to validate the use of classical “saccharin test” in measuring the nasal health by measuring mucociliary clearance time. This study also highlights the effects of AVP by application of Bernoulli principle in ventilation of paranasal sinuses and surface oxygenation of nasal and paranasal sinuses ciliary epithelium. Clinically, endoscopically and radiologically diagnosed patients of Pratishyaya, i.e., rhinosinusitis, satisfying the inclusion criteria were selected to perform AVP as a breathing exercise regularly for 30 min every day in order to evaluate the effectiveness of AVP in resolving features of rhinosinusitis. Saccharin test was performed before and after completion of 40 days trial to assess the nasal ciliary activity, which has been proved to be directly related to the health of ciliary epithelium and nasal health overall as well. AVP may be regarded as a catalyst to conspicuously enhance ventilation and oxygenation of the paranasal sinuses and the positively effect the nasal respiratory epithelium by increasing better surface availability of oxygen and negative pressure in the nasal cavity itself.
doi:10.4103/0974-8520.127714
PMCID: PMC3968697  PMID: 24696572
Anuloma-Viloma Pranayama; Bernoulli principle; mucociliary clearance time; nitric oxide; Pratishyaya (rhinosinusitis) and saccharin test
6.  PA01.35. To study the efficacy of Triphala kwath on Vyang Vyadhi [Chloasma] under the Siddhant of Aparkarshan Chikitsa Siddhant 
Ancient Science of Life  2012;32(Suppl 1):S85.
Purpose:
APAKARSHAN CHIKITSA SIDDHANT: ‘Punarapi Apakarshan’ Ashtang Sangrah 12/6; ‘Apakarshan……’ Charak Viman 7/28. Vyanga Vyadhi Described under Kshudra Roga in various Samhita's. The objective is To study the sign & symptoms of Vyanga. To study the efficacy of Triphala Kwatha on vyanga under the siddhant Apakarshana chikitsa.
Method:
30 patient were taken govt. Ayurved College, Nagpur, Dravyaguna OPD. Drug Triphala Kwatha for Virechanartha. Dose decided as per mrudu, madhyam, krura kostha.
Duration: 1 to 2 months. Criteria of Assessment 30 patients were taken and chloasma was measured & scored (4 0) before treatment and after (1 &2 months) treatment. This data is presented in table. Following gradation were decided: 4 Very Severe dark circle; 3 Severe dark circle; 2 Moderate dark circle; 1 Mild dark circle; 0 Relived dark circle. The data is completely non parametric in nature and symptom severity is a desecrate variable. For coloration distribution is polynomial and so Wilcoxon Signed Rank Test was applied which is equivalent to paired “t test” of parametric analysis.
Result:
Details of statistical analysis of our data is presented below. Vyanga dark circle. Total score of Lakshana before starting the treatment = 89. After first Virechan Karma the total Lakshana score = 89 (0%). After Second Virechan Karma the total Lakshana score = 61(31.46%). After 7 days of second Virechan Karma the total Lakshana score = 61(31.46%) Mean observed second virechan karama as well as 7 days after second virechana karama = 2.0333. The S.D. of this data = 0.8087. Z= 5.112b. P. Value of this data (p < 0.05)
Conclusion:
The data shows significant (p < o.05); After Triphala Kwatha Virechan within 1 months p > 0.05; Triphala Kwatha Virechan after 2 month p < 0.05; Significant result found after 2 month.
PMCID: PMC3800967
7.  A randomized controlled clinical trial to assess the efficacy of Nasya in reducing the signs and symptoms of cervical spondylosis 
Ayu  2012;33(1):73-77.
This work was designed to assess the efficacy of Nasya in reducing the signs and symptoms of cervical spondylosis. The patients attending the O. P. D of Department of Kaya Chikitsa and Panchakarma, Government Ayurveda College Hospital, Thiruvananthapuram were enrolled and subjected to the treatment schedule. Total duration of treatment was 21days. The schedule for the first 14 days was similar in both the groups. It included Rooksha Sveda for 7days followed by Patra Pottali Sveda for 7days. During this period, 90 ml Gandharvahastadi Kashaya twice and Guggulu Tiktaka Kashaya once were given internally. After this, in the Nasya group Nasya was done for 7days with Dhanwantaram Tailam (21times Aavartita), Mridu Paka in Madhyama Matra (8Bindu). Along with this Guggulu Tiktaka Kashaya was given thrice. In the control group, Guggulu Tiktaka kashaya alone was given thrice daily. Assessments were done with regard to pain, tenderness, radiation of pain, numbness, range of movements and hand grip strength. These were done before treatment, before nasya, after treatment and after 1month follow-up. The statistical hypothesis was tested using paired ‘t’ test and ‘Z’ test for proportion. The trial proved that conventional management along with Nasya was more efficacious than conventional management alone in reducing the signs and symptoms of cervical spondylosis.
doi:10.4103/0974-8520.100316
PMCID: PMC3456869  PMID: 23049188
Cervical spondylosis; Gandharvahastadi Kashaya; Guggulu Tiktaka Kashaya; Nasya
8.  EFFICACY OF AYURVEDIC MEDICINE IN THE TREATMENT OF UNCOMPLICATED CHRONIC SINUSITIS 
Ancient Science of Life  2006;26(1-2):6-11.
Thirty patients suffering from uncomplicated chronic Sinusitis were enrolled in a clinical study to asses the efficacy of Ayurvedic medicine comprising of Tribhvan kirti rasa (Tablet) along with inhalation of steam of Dasamulakwath (Decoction) followed by nasya (intranasal instillation) with Anu tailam. The Tribhuvan kirti rasa was administered at a dose of 250mg b.d with Adrak swaras (Juice of Ginger).Steam inhalation of Dasmula kwath was given two times a day followed by nasya of Anu tail at a dose of 4 drops in both nostrils. The duration of the treatment varied from 45 days to 90 days. Radiological tests were done periodically. The patients were examined clinically in every week to asses the effect of medicine. The overall clinical efficacy was 96.6%. This medicine along with steam inhalation followed by Nasya was found to be well tolerated in general and no side effects were reported. Hence this treatment could be recommeed for treatment of chronic Sinusitis.
PMCID: PMC3335227  PMID: 22557218
9.  Role of ‘Krishna Tila’ and ‘Arkapushpa Taila’ Uttarbasti in the Management of Artavakshaya 
Ayu  2010;31(1):76-79.
Ayurvedic classics give importance to Shuddha Artava and mention that Artavadushti is one of the causative factors for infertility. Artavakshaya is not separately described as disease any where in Ayurvedic classics, of course, this doesn’t desecrate Artavakshaya. Because, Acharya Charaka has quoted in Charaka Nidana Sthana, first chapter, that symptoms of a disease themselves also constitute as a disease. But sometime, because of their subordinate nature they are only symptoms and not disease. This quotation substantiates the stand of taking ‘Artavakshaya’ as disease in the present studies. There are many processes and methods available in Ayurvedic classics to alleviate Artavakshya. But it is yet, the on going research to find out a method of treatment, which is nearer to procurance of permanent cure without side effects. It is well known that Ayurvedic classics emphasize on both Shodhana and Shamana therapy. Since Vata plays key role in Yoniroga, Uttarbasti, being Vata shamana, is a specific treatment in diseased condition of Yoni. As Shamana therapy Kwatha preparation choose to evaluate its efficacy. In the present study total 37 patients were registered, out of them 6 patients were discontinued. One group of patients was administered Arkapushpa Taila Uttarbasti and Krishna Tila Kwatha simultaneously. It gave more significant result. Krishna Tila Kwatha was administered orally in other group. Placebo wheat powder was administered orally in third group. Uttarbasti and Kwatha were found highly effective when administered simultaneously.
doi:10.4103/0974-8520.68200
PMCID: PMC3215327  PMID: 22131689
Artavakshaya; Krishna Tila; Arkapushpa Taila; Oligomenorrhoea; Hypomenorrhoea; Secondary amenorrhoea
10.  Management of Vyanga (facial melanosis) with Arjuna Twak Lepa and Panchanimba Churna 
Ayu  2014;35(1):50-53.
Background:
Vyanga is one of the Kshudraroga, characterized by the presence of Niruja (painless) and Shavavarna Mandalas (bluish-black patches) on face. It is one of the most common diseases as regards the face is concerned. On the basis of clinical features, it can be compared with facial melanosis, one of the hyper pigmented disorders. Drugs with Rakta Prasadaka, Twak Prasadaka and Varnyakara properties are helpful in the management of Vyanga, that pacifies aggregated Doshas and help in Raktashodhana (blood purification).
Aim:
To evaluate the efficacy of Arjunatwak Lepa and Panchanimba Churna in Vyanga.
Materials and Methods:
In this study, the trial drugs used were Arjunatwak Churna for Lepa (tropical application) and Panchanimba Churna for oral administration. A total 30 patients of Vyanga were selected from outpatient department and inpatient department of Shalakya Tantra Department and allotted randomly in two groups. In group-A, the patients were treated with external application of Arjunatwak Churna and Madhu for 21 days, while in group-B, patients received Panchanimba Churna orally for 21 days in addition to Arjunatwak Churna for Lepa. Effect of therapy on chief complaint i.e., bluish-black pigmentation in Group A was 60% relief, while in Group B 80% relief was found.
Conclusion:
The clinical study has shown that combined therapy gives better results than topical treatment.
doi:10.4103/0974-8520.141924
PMCID: PMC4213969  PMID: 25364200
Arjunatwak Churna; facial melanosis; Panchanimba Churna; Vyanga
11.  Role of honey (Madhu) in the management of wounds (Dushta Vrana) 
Application of Madhu (honey) is one among the Shashthi Upakrama (sixty treatment modalities) described by Sushruta. Clinical observation has shown its effectiveness in treatment of Dushta Vrana (chronic wounds). We report a case of Dushta Vrana on the anterior aspect of the right leg that was treated successfully with local application of Madhu and Neem (Azadirachata indica) bark decoction.
doi:10.4103/0974-7788.76793
PMCID: PMC3059452  PMID: 21455457
Dushta Vrana; Madhu; Neem bark; Shashthi Upakrama
12.  Safety and efficacy of Nasya/Prevalin in reducing symptoms of allergic rhinitis 
The Clinical Respiratory Journal  2013;8(4):382-390.
Background
Nasya/Prevalin is a natural, drug-free nasal spray for treatment and prevention of allergic rhinitis. Because of its thixotropic property, it forms a barrier on the nasal mucosa, preventing allergen contact. This study assesses the clinical efficacy and safety of Nasya/Prevalin in a nasal provocation test with house dust mite allergens.
Methodology/Principal
In this randomised, double-blind, placebo-controlled trial, 20 subjects suffering from allergic rhinitis because of house dust mite allergens received a single dose of Nasya/Prevalin or saline spray before allergen challenge. Total nasal symptom score and total ocular symptom score were assessed 15, 30, 60, 75, 90, 120 and 240 min after challenge. Further, the appearance of the mucosa was examined by rhinoscopy.
Results
A single treatment with Nasya/Prevalin led to a significant reduction of TNSS at 60, 75 and 90 min after dust mite allergen challenge as compared with placebo (pVCAS = 0.021, pVCAS = 0.035, pVCAS = 0.036, respectively). Mucosa changes assessed by the rhinoscopic score (on swelling, secretion and colour) were significantly worse in the placebo group compared with the Nasya/Prevalin group (P = 0.033). Nasya/Prevalin was well tolerated, and the safety was comparable with placebo.
Conclusions
Treatment with Nasya/Prevalin was effective in preventing allergic reactions induced by dust mite allergen challenge.
Please cite this paper as: Stoelzel K, Bothe G, Chong PW and Lenarz M. Safety and efficacy of Nasya/Prevalin in reducing symptoms of allergic rhinitis. Clin Respir J 2014; 8: 382–390.
doi:10.1111/crj.12080
PMCID: PMC4235399  PMID: 24279907
allergic rhinitis; allergy prevention; clinical trial; placebo-controlled; randomised
13.  PA01.80. The review of herbal anti-allergy and anti-histaminic drugs 
Ancient Science of Life  2012;32(Suppl 1):S130.
Purpose:
The symptoms of an allergic reaction communicate sensitization to certain antigens in the environment. Initiation of antigen reaction stimulates mast cells to release histamine into the blood which interacts with the cells to produce most of the symptoms of the allergy. Drugs that block only the action of histamine are known as antihistaminic while the drugs preventing mast cells from releasing histamine are considered as anti allergic agents. Ayurveda considers Mandagni (Jadharagni in hypofunctional state) as the root cause of the all diseases which produces Ama (Antigen/Visha). Drugs possessing Deepan, Pachan, and Vishaghna properties may prevent histamine release and allergic reactions. Udardaprashamana, Kandughna, Swasahara group of drugs may prevent acute histaminic reaction. Keeping this concept in view a critical review was made about the herbs mentioned in the classical Ganas and aushadhyogas of compilatory works of medieval India in addition to reported activities during 20th century research works. The study aims to identify herbs with Antihistaminic and Antiallergy activity and to discuss safety and efficacy of herbal anti histaminics over the drugs of modern medicine which may produce certain adverse effects like nausea, drowsiness, nasal burning etc.
Method:
Analysis of drugs mentioned in the management of pratishyaya, shwas, kasa, and skin conditions like Seetpitta, Udarda, Vicharchika etc. was made. Review of research data mentioned in various journals and monographs was also analysed.
Result:
Vishaghna and Udardaprashamana dashemani may have profound activity in controlling allergic reactions. Kandughna Dashemani may be useful to control fungal and allergic skin diseases. Pippali, Tulsi, Kantakari may be useful in the management of allergic disease of respiratory tract. Azadirachta indica (Nimba), Albezzia lebbeck (Shirish), Glycerrhyza glabra (Yashtimadhu) etc. have provided ample scientific evidence for antihistaminic activity.
Conclusion:
Recent researches confirmed Anti histaminic and Anti allergic activity of Adhatoda vasica (vaasaa), Aloe vera (kumari), Azadirachta indica (nimba), Curcurma zedoaria (karchura), Nigella sativa (upakunchikaa), Inula racemosa (pushkarmoola), Tinospora cordifolia (guduchi), Benincasa hispida (krushmanda) etc. which are safer to use.
PMCID: PMC3800886
14.  Efficacy of Virechana and Basti Karma with Shamana therapy in the management of essential hypertension: A comparative study 
Ayu  2013;34(1):70-76.
Considering high prevalence and the need to look for alternative medicine, essential hypertension was screened in light of Vata–Pitta Pradhana Rakta Pradoshaja Vikara as mentioned by Acharya Charaka. Comparing the etiological factors, symptomatology, and complications with Rakta Pradoshaja Vikara with that of essential hypertension, a striking similarity was revealed. To prove the practical approach of management of Vata–Pitta Pradhana Rakta Pradoshaja Vikara, a randomized open clinical trial on 33 uncomplicated subjects of essential hypertension was conducted. The subjects were allotted in two groups, viz. (Group A) Virechana group having 16 cases who underwent Virechana Karma by Trivrita, Aragvadha, Eranda Taila, and Draksha Kwatha as Sahapana; and (Group B) Basti group consisting of 17 cases who were administered Dashmoola Kala Basti in which Niruha with Dashmoola Kwatha and Anuvasana with Dashmoola Taila was done. Patients of both the groups were followed by Shamana Chikitsa (Arjunadi Ghanavati). The overall effect of the therapies on systolic and diastolic blood pressure showed that Virechana proved better relief (43.75%) as compared to Basti (29.41%). The response was encouraging and has created scope for further studies.
doi:10.4103/0974-8520.115455
PMCID: PMC3764884  PMID: 24049408
Basti Karma; essential hypertension; Raktapradoshaja Vikara; Virechana Karma
15.  A comparative study on Vamana Karma with Madanaphala and Krutavedhana in Ekakushtha (Psoriasis) 
Ayu  2011;32(4):487-493.
Vamana Karma (therapeutic emesis) is the best therapy for the elimination of vitiated Kapha Dosha. In the present clinical practice Madanaphala (Randia dumetorum) is mainly used for Vamana Karma. Apart from Madanaphala, five other drugs, and in total 355 formulations are described in Charaka Samhita; one of them is Krutavedhana (Luffa acutangula) kalpa (formulations). Krutavedhana is specially indicated in Gadha (compact) Dosha condition like Kushtha (skin diseases), Garavisha (slow poison), and so on, for Vamana Karma. The present study aimed to observe the effect on Vamana Karma and by that its effect on Ekakushtha (Psoriasis). Krutavedhana Beeja Churna (seed powder) was given with Madhu (honey) and Saindhava (rock salt) as Vamana Yoga (emetic formulation), to compare it with Madanaphala Pippali Churna (seed powder). After the Sansarjana Krama (special dietetic schedule), Panchatikta Ghrita (medicated ghee) was given as Shamana Sneha (pacifying oleation). An average dose of Krutavedhana was 5.9 g. Krutavedhana could produce a good number of Vega (bouts), Pittanta Lakshana (bile coming out at the end of Vamana), and Pravara Shuddhi (maximum cleansing) in a majority of patients. Madanaphala is the best among all Vamaka (emetic) drugs, but Krutavedhana showed a similar to higher effect on Vamana Karma in terms of Antiki, Maniki, Vaigiki, and Laingiki Shuddhi (cleansing criteria). Vamana Karma by Krutavedhana showed better relief in Matsyashakalopamam (silvery scale), Kandu (itching), and Rukshataa (dryness), while Madanapahala showed better relief in Krishnaruna Varna (erythema). After completion of the Shamana (pacifying) treatment, both the groups showed nearly the same effect on Asvedanam (lack of perspiration), Matsyashakalopamam, Kandu, Rukshataa, Krishnaruna Varna, and Mahaavaastu (bigger lesion).
doi:10.4103/0974-8520.96121
PMCID: PMC3361923  PMID: 22661842
Ekakushtha; Krutavedhana; Madanaphala; Panchatikta Ghrita; Psoriasis; Vamana Karma
16.  PA01.25. Clinical evaluation of chitrakadi churna and kshar basti in the management of amavata with special reference to rheumatoid arthritis 
Ancient Science of Life  2012;32(Suppl 1):S75.
Purpose:
The disease Amavata can be presented as very similar to Rheumatoid Arthritis. Rheumatoid Arthritis is chronic in nature and affects mostly middle aged people. For this disease there is no satisfactory medicine is available till date. But in Ayurveda there are many drugs described for Amavata which are cost effective and easily available with no side effects. The present clinical study evaluated the effect of Chitrakadi Churna and Kshar Basti in the management of Amavata.
Method:
30 clinically diagnosed patient of Amavata were registered and completed the trial. In this 15 patients (Group A) administered Chitrakadi Churna 4gm twice daily with lukewarm water after meal. Another 15 patients (Group B) administered Chitrakadi Churna 4gm twice daily with lukewarm water after meal and Kshar Basti as per Kalbasti krama i.e 16days followed by local Snehan Swedan.
Result:
Results of this trial were encouraging as there is improvement in each symptom of patient like pain, stiffness, swelling, and tenderness. Group A in which only Chitrakadi Churna was administered there was no significant improvement seen statistically. But Group B in which Chitrakadi Churna as well as Kshar Basti was administered highly significant improvement seen statistically. Details of the Statistical test and other important will be discussed at the time of paper presentation.
Conclusion:
From present clinical trial it is concluded that this therapy is very useful for pain, swelling, tenderness and stiffness, which were chief complaint of the patient. Chronicity more than 3 years did not show marked improvement. And also this drug is supposed to be very good combination of Vedanashamaka, Shothaghna, Amapachaka Dravyas. No untoward effects were seen except mild loss of weight.
PMCID: PMC3800956
17.  Effect of Shatapushpa Taila Matra Basti and Pathadi Kwatha on Poly Cystic Ovarian Disease 
Ayu  2012;33(2):243-246.
Poly Cystic Ovarian Disease (PCOD) is a complex disorder affecting 5-15% women in their reproductive age and related to ovarian dysfunction, characterized by menstrual irregularities, hyperandrogonism, obesity, and infertility. In Ayurveda, these symptoms are found under various conditions, caused by vitiated Vata and Kapha. Pathadi Kwatha and Shatapushpa Taila Matra Basti were studied in the current attempt to evaluate their comparative efficacy in cases of PCOD. Total 34 patients of PCOD were registered among which, 32 had completed the treatment of 2 months. They were randomly divided in to three groups. In group A Pathadi Kwatha (10 g, bid) and Shatapushpa Taila Matra Basti (60 ml for 7 days after cessation of menses for 2 consecutive cycles) were administered. In group B only Basti, whereas in group C capsules of roosted wheat flour were administered. Better results were obtained in group A especially in menstrual irregularities, achieving follicular growth and in weight reduction.
doi:10.4103/0974-8520.105245
PMCID: PMC3611647  PMID: 23559797
Artavavaha Srotas; Matra Basti;  ovarian functions; Pathadi Kwatha;  PCOD; Shatapushpa Taila
18.  Role of Nasya and Matra Basti with Narayana Taila on anovulatory factor 
Ayu  2013;34(1):81-85.
Description of Vandhyatva is available in most of the Ayurvedic classics, including Nidana (diagnosis), Samprapti (etiopathogenesis), Lakshana (symptomatology), Bheda (types) and Chikitsa (treatment). In current study, efforts have been made to study the effect of Nasya and Matra Basti on anovulation (Beeja Dushti). Ovulation is under the control of Vata. Narayana Taila is attributed for its effect in Vandhyatva. 24 patients of female infertility having anovulatory factor, being diagnosed by Trans-Vaginal Sonography (TVS) for 2 consecutive cycles were divided in two groups. Patients in Group A (n = 12) administered the drug through Nasya and in Group B (n = 12) through Matra Basti. Ovulation occurred 36.36% of patients in group A and 66.16% of patients group B. Matra Basti showed better results than Nasya group on anovulation.
doi:10.4103/0974-8520.115453
PMCID: PMC3764886  PMID: 24049410
Anovulation; infertility; Matra Basti; Narayana Taila; Nasya; Vandhyatva
19.  144 Evaluation of Various Forms of Sinusitis Using Bone Spect 
Background
Computed tomography (CT), a standard diagnostic technique used to evaluate the extent of the sinus disease, fails to show bone involvement in patients with sinusitis. Bone scintigraphy is the gold standard procedure for detecting the bone involvement. Osteitis may be one of the reasons for discrepancies between extent of the disease as evaluated by CT and symptom scores. The aim of the study was to determine whether or not nuclear scintigraphy is useful in the diagnosis and management of acute, complicated acute and chronic sinusitis.
Methods
Forty patients with sinusitis were involved (9 acute, 4 complicated acute, 27 chronic sinusitis). 20 of the chronic sinusitis patients were with nasal polyps. All patients were evaluated with CT and SPECT (Single-photon emission tomography). 99Technetium-methylenediphosphate (99Tc-MDP) was administered for scintigraphic examination of the skull. Abnormal patterns of increased radionuclide uptake were identified and subjectively described. The mucosal involvement of sinusitis graded on Lund-Mackay Scale (LMS) was compared to degree of bone involvement evaluated by SPECT.
Results
While, SPECT uptakes were negative (mean uptake index is less than about 2.5) in acute sinusitis, it's highly positive (mean uptake index is more than about 4) in complicated acute sinusitis. In group of chronic sinusitis, a positive correlation between the SPECT uptakes and LMS grade was found (P < 0.05).
Conclusions
In our view, the bone involvement as evaluated by SPECT correlates with the stage of chronic sinusitis. Poorer subjective response was observed in patients with positive SPECT. The clinical value of scintigraphy, is limited to special indications.
doi:10.1097/01.WOX.0000411889.29277.dc
PMCID: PMC3512851
20.  PA02.13. Invitro antimicrobial study of Gojihwadi kwatha ghana with special reference to upper respiratory tract infection 
Ancient Science of Life  2013;32(Suppl 2):S58.
Purpose:
Bhaishajya Kalpana is a specialized branch of Ayurveda which deals with the procurement, processing and right application of a drug to cure any diseases. Simply it is an art of preparing and dispensing of medicine. Gojihwadi Kwatha is a most common drug used in ailment of upper respiratory system, such as Pratishyaya, Kasa, Shwasa in day to day clinical practice. Extracts of Gojihwadi Kwatha was done with an intention to evaluate its efficacy against selected URTI (Upper respiratory tract infection) causing pathogenic microorganism.
Method:
Different extracts were prepared by extracting samples of Gojihwadi Kwatha Ghana were tested for their antimicrobial activity against pathogenic organisms.
Result:
Ghana of Gojihwadi Kwatha showed significant inhibition of various microbes related to URTI specially Pseudomonas aeruginosa, Klebsillae pneumonae and Proteus vulgaris. Hence efficacy of Gojihwadi Kwatha as mentioned in classical text is hereby scientifically validated.
Conclusion:
Results suggest Gojihwadi Kwatha is efficacious against URTI (Upper respiratory tract infection) causing pathogenic microorganism.
doi:10.4103/0257-7941.123877
PMCID: PMC4147530
21.  Clinical evaluation of the efficacy of Dashanga Kwatha Ghana Vati in the management of Urdhwaga Amlapitta (Non-ulcer dyspepsia) 
Ayu  2012;33(2):219-223.
A study has been designed to evaluate the effectiveness of Dashanga Kwatha Ghana Vati in Urdhwaga Amlapitta (non-ulcer Dyspepsia). Randomized single blind, placebo controlled study was conducted in 138 patients attending O.P.D. of department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, and grouped into two. Both the groups consumed two tablets of either Dashanga Kwatha Ghana Vati or placebo, twice daily after food for a period of eight weeks. The patients were followed upto four weeks, 110 patients had completed the treatment and no adverse effects were reported during the treatment. Both groups had improved in the clinical symptoms and overall statistical significance was observed in the differences of scores between the two groups.
doi:10.4103/0974-8520.105241
PMCID: PMC3611627  PMID: 23559793
Dashanga Kwatha Ghana Vati; non-ulcer dyspepsia; Urdhwaga Amlapitta
22.  Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus 
Ayu  2012;33(4):537-541.
Microalbuminuria is the strong predictor of diabetic nephropathy, which is the main cause of morbidity and mortality in patients with diabetes mellitus (DM). Microalbuminuria is also characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. The study was planned to evaluate the effect of Gokshura-Punarnava Basti in the management of microalbuminuria in DM (Madhumeha). Eligible diabetic patients with urine albumin excretion between 30 and 300 mg in 24 h were randomly divided into two groups. Asthapana Basti (decoction enema) of Gokshura and Punarnava Kwatha (decoction), Kalka (paste), Taila (medicated oil), Madhu (honey), and Saindhava (rock salt) for 6 consecutive days and Anuvasana (unctuous enema) of Gokshura-Punarnava Taila on 1st and 8th day by traditional Basti Putaka method was given in study group. Tablet Enalapril 5 mg, twice daily for 30 days was given to the patients in control group. The primary outcome measures were percentage change in the presenting complaints of diabetes, urine microalbumin, Blood Sugar Level (BSL), and Blood Pressure (BP). Enalapril showed 33.33% improvement, where as Gokshura-Punarnava Basti showed 79.59% improvement in the presenting complaints of diabetes, urine microalbumin, BSL and BP. Gokshura-Punarnava Basti has shown superior results in the management of microalbuminuria in DM as compared to control drug.
doi:10.4103/0974-8520.110535
PMCID: PMC3665195  PMID: 23723672
Basti; diabetes mellitus; Gokshura; Madhumeha; microalbuminuria; Punarnava1
23.  PA01.09. Efficacy of ayurvedic formulations in allergic asthma patients with special reference to elevation of TIgE 
Ancient Science of Life  2012;32(Suppl 1):S58.
Purpose:
Allergic Asthma Tamaka swasa is one of the most distressing common diseases that affect a sizable number of world populations. Internal and external allergens such as environmental change, pollutants and unsuitable foods are believed to be the predisposing factors which sensitize the immune system of the body and trigger production of the antibody Immunoglobulin E. These result in sneezing, running nose, irritation of eyes, inflammation of bronchial mucosa and wheezing. Ayurvedic formulations such as Dasamoolakatuthrayam kwatha, Vyoshadi vatakam, Swasanandam gutika and Swasa kalpa are widely used by Ayurvedic physicians and clinically proven to have anti allergic effect. They relieve bronco spasm, airway block, sneezing and running nose. Current study was aimed at proving the efficacy of these formulations in Allergic Asthma.
Method:
Patients diagnosed with Allergic Asthma were chosen for clinical study. A total of 38 patients of either sex ranging from the age of 4 to 48 were selected for the study. All the patients were tested for their blood level TIgE. Most of them were found to have elevated blood level TIgE. Every patient was given Dasamoolakatuthrayam kwatha, Vyoshadi vatakam, Swasanandam gutika and Swasa kalpa orally for 6 8 weeks and the progress was observed. The observations were recorded based on subjective and objective methods.
Result:
It was construed from the results that the trial medicines had significantanti allergic, expectorant, bronco dilatation and overall reduction in the symptoms of Allergic Asthma in the analyzed patients. By the end of 8 weeks 16 out of 38 patients had significant recovery from the symptoms, 18 had good control of the ailment while the rest 4 displayed poor progress.
Conclusion:
The study vividly fortified the therapeutic efficacy of the trial drugs in the management of Allergic Asthma. Besides relieving the symptoms, the drugs significantly reduced the elevated TIgE in the blood.
PMCID: PMC3800938
24.  OA01.36. Management of diabetic retinopathy with doorvadya ghrita tarpana and internal administration of mahavasadi kwatha- a comparative study 
Ancient Science of Life  2012;32(Suppl 1):S36.
Purpose:
A comparative clinical study was conducted on the management of Diabetic Retinopathy (DR) with Doorvadya Ghrita Tarpana and Mahavasadi kwatha internally. The main aim and objective of the study was to evaluate the efficacy of Doorvadya ghrita Tarpana and Mahavasadi kwatha internally, when used individually and as an adjuvant.
Method:
The patients were randomly divided in 3 groups with 15 patients in each group. Group A: Tarpana with Doorvadya Ghrita for 3 sittings, 5 days in each sitting, with a gap of 11 days after each sitting, total 48 days duration. Group B: Mahavasakadi Kwatha Pana with 50ml dose every day in the morning, empty stomach, for 48 days. Group C: Both Doorvadya Ghrita Tarpana and Mahavasakadi kwatha pana, for 48 days.
Result:
All the three groups have shown statistically significant results. Group B and C have shown better response as compared to Group A. Moreover Group B has shown slightly better response as compared to Group C.
Conclusion:
The study showed that microaneurysms, intra retinal haemorrhages, exudates are best managed by treatment with Group-B; where as blurred vision responded better to combine treatment of Group-C. Other parameters like neovascularization did not produce any significant result in any of the groups. Hence Ayurvedic management definitely prevents further progression of the Diabetic Retinopathy and its complications.
PMCID: PMC3800914
25.  Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria) 
Ayu  2013;34(3):249-253.
Veerataru is quoted to be effective in various conditions of Mootravaha Srotodushti such as Mootrakruchchhra (Dysuria), Mootraghata (Anuria), Ashmari (Urinary calculi), Sharkara (Concretions) etc., by various Acharyas. Mootrakruchchhra (Dysuria) is a disease of Basti (Bladder). It comes under Mootraapravruttijanyavyadhi, where Kruchchhrata (Shoola –Pain and Daha-Burning) during mootra pravrutti is the chief symptom. As per modern view, dysuria is a leading feature of lower or mid urinary tract infection. Antibiotics have their own limitations due to re-infections and recurrence even after long-term therapy, due to development of resistance of the microorganisms to the drugs. By considering all the above facts and to fulfill the lacuna about the absence of scientific data of Veerataru, the present research work had been taken up especially to evaluate its efficacy on Mootrakruchchhra (Dysuria). Patients suffering from Mootrakruchchhra (Dysuria) were selected and divided into two groups, i.e. Group A received Kwatha (decoction) of Veerataru-Dichrostachys cinerea Linn. (Trial drug) and Group B received Kwatha of Punarnava-Boerhaavia diffusa Linn. (Standard control) respectively. The effects of therapy were assessed by a specially prepared clinical research proforma. The result showed better symptomatic relief in Group A, i.e. trial drug as compared to Group B, i.e. standard control group.
doi:10.4103/0974-8520.123105
PMCID: PMC3902588  PMID: 24501517
Mootrakruchchhra; Veerataru (Dichrostachys cinerea Linn.); Mootravaha Srotodushti

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