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1.  OA03.18. “A comparative study of kati basti with sahacharadi taila and maha narayana taila in the management of gridhrasi (Sciatica)” 
Ancient Science of Life  2013;32(Suppl 2):S41.
The symptoms seen in Gridhrasi can be well correlated with “Sciatica” in modern terminology. Moreover, the modern treatment of sciatica is not very satisfactory and includes use of analgesics and few surgical procedures which is often associated with many adverse effects Among the Panchakarma therapy; Kati Basti is reliable to control the disease. Hence an attempt is made to compare the effect of Kati Basti with Sahacharadi Taila and Maha Narayana Taila in the management of Gridhrasi
It was an open clinical study with a pre and post design, for the duration of 14days for both Kati Basti groups 90 patients, fulfilling the inclusion and diagnostic criteria, were selected and randomly divided into 2 groups with 45 patients in each group. In Group A, Kati Basti with Sahacharadi Taila was administered daily during the trial period while In Group B, Kati Basti with Maha Narayana Taila was administered daily.
•Kati basti with Maha Narayan Taila group and Kati basti with Sahacharadi Taila group showed almost same percentage relief in all assessment parameters.
•Both group showed higest percentage relief in the Functional ability while no relief in the Aruchi •Kati basti with Sahacharadi Taila is more effective to control Kapha dominance symptoms like Stambha, Graha, Gaurava and Tandra and also on walking distance and magnitude of Pain
•Kati basti with Maha Narayan Taila group is more effective to control vata dominance symptoms like Ruk, Toda, Numbness, Burning Sensation and Muhuspandana and also on the Functional ability, Sakthikshepanigraha and the functional disability.
Kati basti with Sahacharadi Taila and with Maha Narayan Taila is almost equally effective in the management of Gridhrasi but Kati basti with Sahacharadi Taila is more effective to control Kapha dominance symptoms while Kati basti with Maha Narayan Taila group is more effective to control vata dominance symptoms.
PMCID: PMC4147512
2.  Effect of Shatapushpa Taila Matra Basti and Pathadi Kwatha on Poly Cystic Ovarian Disease 
Ayu  2012;33(2):243-246.
Poly Cystic Ovarian Disease (PCOD) is a complex disorder affecting 5-15% women in their reproductive age and related to ovarian dysfunction, characterized by menstrual irregularities, hyperandrogonism, obesity, and infertility. In Ayurveda, these symptoms are found under various conditions, caused by vitiated Vata and Kapha. Pathadi Kwatha and Shatapushpa Taila Matra Basti were studied in the current attempt to evaluate their comparative efficacy in cases of PCOD. Total 34 patients of PCOD were registered among which, 32 had completed the treatment of 2 months. They were randomly divided in to three groups. In group A Pathadi Kwatha (10 g, bid) and Shatapushpa Taila Matra Basti (60 ml for 7 days after cessation of menses for 2 consecutive cycles) were administered. In group B only Basti, whereas in group C capsules of roosted wheat flour were administered. Better results were obtained in group A especially in menstrual irregularities, achieving follicular growth and in weight reduction.
PMCID: PMC3611647  PMID: 23559797
Artavavaha Srotas; Matra Basti;  ovarian functions; Pathadi Kwatha;  PCOD; Shatapushpa Taila
3.  Clinical effect of Matra Basti and Vatari Guggulu in the management of Amavata (rheumatoid arthritis) 
Ayu  2010;31(3):343-350.
Amavata is the most crippling of the joint diseases. It occurs throughout the world in all climates and all ethnic groups. Though all the Doshas take part in the causation of this disease, Ama and vitiated Vata play the dominant role. The clinical features of rheumatoid arthritis, such as pain, swelling, stiffness, fever, and general debility, are almost identical to that of Amavata. Treatment provides symptomatic relief, but the underlying pathology remains unchecked because of the absence of effective drugs. In the management of Amavata all the acharyas have described the sequential employment of Dipana, Amapachan, Shodhan, and Shaman therapies. For this study, 118 patients of Amavata were randomly divided into two groups. The patients in group A (50 patients) were given Matra Basti with Brihat Saindhavadi Taila along with Vatari Guggulu; the patients in group B (53 patients) were given only Vatari Guggulu. All the patients responded favorably to the treatment in both the groups; however, patients treated with Matra Basti had better relief in most of the cardinal signs and symptoms of the disease.
PMCID: PMC3221069  PMID: 22131737
Vatari Guggulu; Matra Basti; Amavata; rheumatoid arthritis; Vata; Brihat Saindhavadi Taila
4.  Role of Nasya and Matra Basti with Narayana Taila on anovulatory factor 
Ayu  2013;34(1):81-85.
Description of Vandhyatva is available in most of the Ayurvedic classics, including Nidana (diagnosis), Samprapti (etiopathogenesis), Lakshana (symptomatology), Bheda (types) and Chikitsa (treatment). In current study, efforts have been made to study the effect of Nasya and Matra Basti on anovulation (Beeja Dushti). Ovulation is under the control of Vata. Narayana Taila is attributed for its effect in Vandhyatva. 24 patients of female infertility having anovulatory factor, being diagnosed by Trans-Vaginal Sonography (TVS) for 2 consecutive cycles were divided in two groups. Patients in Group A (n = 12) administered the drug through Nasya and in Group B (n = 12) through Matra Basti. Ovulation occurred 36.36% of patients in group A and 66.16% of patients group B. Matra Basti showed better results than Nasya group on anovulation.
PMCID: PMC3764886  PMID: 24049410
Anovulation; infertility; Matra Basti; Narayana Taila; Nasya; Vandhyatva
5.  A clinical study of Nirgundi Ghana Vati and Matra Basti in the management of Gridhrasi with special reference to sciatica 
Ayu  2010;31(4):456-460.
Gridhrasi can be equated with sciatica, where pain, weakness, numbness, and other discomforts along the path of the sciatic nerve often accompanies low back pain. It is a common affliction of adults, costing billions of dollars in healthcare and resulting in more lost days of work than any other illness but the common cold. A herniated disc, spinal stenosis, piriformis syndrome, etc., can all cause sciatica. The treatment available for sciatica in modern medicine is not very satisfactory.The role of research in Ayurveda is to elucidate the underlying principles and to explain them in modern parameters. The present study was aimed at establishing clinically the effect of Nirgundi (Vitex negundo) Ghan Vati (dried water extract) alone as well as in combination with Matra Basti in the management of Gridhrasi. A total of 119 patients were registered for the study, out of which 102 patients completed the treatment: 52 patients in group A (Nirgundi Ghan Vati) and 50 in group B (Nirgundi Ghan Vati + Matra Basti). The results show that both treatments had an effect on Gridhrasi, but there was better relief of the signs and symptoms in group B. Matra Basti and Nirgundi Ghan Vati might both contribute to different extents in the recovery of the patient.
PMCID: PMC3202251  PMID: 22048539
Gridhrasi; sciatica; Nirgundi Ghana vati; Vitex negundo; therapeutic enema; Matra Basti
6.  A Clinical study of Matra Vasti and an ayurvedic indigenous compound drug in the management of Sandhigatavata (Osteoarthritis) 
Ayu  2010;31(2):210-217.
Sandhigatavata is described under vatavyadhi in all ayurvedic classical texts. Osteoarthritis is the most common articular disorder which begins asymptomatically in the second and third decades and is extremely common by age 70. Here Matra Vasti (therapeutic enema) was given with Bala taila as Vasti is the best treatment for vatavyadhies. It has vatashamaka and rasayana properties. Indigenous compound drug containing Guggulu, Shallaki, Yastimadhu, Pippali, Guduchi, Nirgundi, Kupilu and Godanti was given in one group along with Matra Vasti. In this study, 33 patients of Sandhigatavata completed the treatment. Patients were randomly divided into two groups. Sixteen patients in Group-A (sarvanga Abhyanga-swedana + matravasti) and 17 patients in Group-B (sarvanga Abhyanga–swedana+ matravasti + indigenous compound drug). The results of the study indicate that the patients of both the groups obtained highly significant relief in almost all the signs and symptoms of Sandhigatavata.
PMCID: PMC3215366  PMID: 22131712
Abhyanga; indigenous compound drug; Matra Vasti; osteoarthritis; Sandhigatavata; swedana; vatavyadhi; therapeutic enema.
7.  Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus 
Ayu  2012;33(4):537-541.
Microalbuminuria is the strong predictor of diabetic nephropathy, which is the main cause of morbidity and mortality in patients with diabetes mellitus (DM). Microalbuminuria is also characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. The study was planned to evaluate the effect of Gokshura-Punarnava Basti in the management of microalbuminuria in DM (Madhumeha). Eligible diabetic patients with urine albumin excretion between 30 and 300 mg in 24 h were randomly divided into two groups. Asthapana Basti (decoction enema) of Gokshura and Punarnava Kwatha (decoction), Kalka (paste), Taila (medicated oil), Madhu (honey), and Saindhava (rock salt) for 6 consecutive days and Anuvasana (unctuous enema) of Gokshura-Punarnava Taila on 1st and 8th day by traditional Basti Putaka method was given in study group. Tablet Enalapril 5 mg, twice daily for 30 days was given to the patients in control group. The primary outcome measures were percentage change in the presenting complaints of diabetes, urine microalbumin, Blood Sugar Level (BSL), and Blood Pressure (BP). Enalapril showed 33.33% improvement, where as Gokshura-Punarnava Basti showed 79.59% improvement in the presenting complaints of diabetes, urine microalbumin, BSL and BP. Gokshura-Punarnava Basti has shown superior results in the management of microalbuminuria in DM as compared to control drug.
PMCID: PMC3665195  PMID: 23723672
Basti; diabetes mellitus; Gokshura; Madhumeha; microalbuminuria; Punarnava1
8.  PA01.65. Comparative study of kumari swarasa and kanyasara in management of kashtartava 
Ancient Science of Life  2012;32(Suppl 1):S115.
Kumari (Aloe barbadensis Mill.) is a miracle plant. In Ayurvedic Texts Kumari has raspanchaka as: Guna Guru, Snigdha, Pichhial; Rasa Tikta, Madhur; Vipaka Katu; Veerya Sheeta whereas Kanyasara has rasa panchaka as: Guna Laghu Ruksha, Teekshna; Rasa Katu; Veerya Ushna ; Vipaka Katu. On the basis of different raspanchaka comparative study has been done to analyse its effect in the management of Kashtartava.
30 patients of age group 15 35 were selected randomly, group 1 (15 patients) was given Kumari Swarasa 10 ml BD and group 2 (15 patients) was given Kanyasara Vati 250 mg BD for10 days before expected commencement of Menstrual cycle for 3 menstrual cycles.
Group 2 showed 25.11% more relief than group I which is significant at p<0.05. (t =3.283). Kanyasara having Katu rasa and Katu vipaka which has predominance of Vayu + Agni mahaboota. It has Strotasa shodhna & Kaphahara activities due to which it removes clots, increases flow of menstrual blood and due to Ushna Virya it improves rhythmic contractions of uterus.
In-group 1) 5 were improved it was effective in premenstrual symptoms like anorexia etc. In group 2) 5 Patients were markedly improved, 9 moderately improved in over all symptoms. Hence Kanyasara is best line of treatment in Kashtartava.
PMCID: PMC3800869
9.  Exploratory Study on the Ayurvedic Therapeutic Management of Cerebral Palsy in Children at a Tertiary Care Hospital of Karnataka, India 
Cerebral palsy (CP) is the leading cause of childhood disability affecting cognitive function and developments in approximately 1.5 to 3 cases per 1000 live births. Based on Ayurvedic therapeutic principles, CP patients were subjected to Abhyanga (massage) with Moorchita Tila Taila (processed sesame oil) and Svedana (fomentation) with Shastikashali Pinda Sveda (fomentation with bolus of drugs prepared with boiled rice). Study group received Mustadi Rajayapana Basti (enema with herbal decoction) and Baladi Yoga (a poly-herbo-mineral formulation), while the placebo group received Godhuma Vati (tablet prepared with wheat powder) and saline water as enema. Treatment with Mustadi Rajayapana Basti and Baladi Yoga improved the activities of daily life by 8.79%, gross motor functions by 19.76%, and fine motor functions 15.05%, and mental functions like memory retention got improved by 15.43%. The placebo group showed an improvement of 0.21% in daily life activities, 2.8% in gross motor, and 2.4% in fine motor functions. Mustadi Rajayapana Basti and Baladi Yoga proved to be more supportive in improving the motor activities and gross behavioral pattern. Further clinical trials are required to evaluate and validate the maximum effect of the combination therapy in a large sample with repetition of the courses for longer duration.
PMCID: PMC4032842  PMID: 24872933
Abhyanga; Baladi Yoga; Cerebral palsy; Moorchita Tila Taila; Mustadi Rajayapana Basti; Shastikashali Pinda Sveda
10.  PA01.77. Clinical study on effect of Tila Taila Pana on Karshya wsr to Vata Dominating Prakriti) 
Ancient Science of Life  2012;32(Suppl 1):S127.
The diseases related to nutrition constitute the most important health problem of the world. It may be due to over nutrition in the form of obesity (Sthula) as in developed countries and due to under nutrition in the form of underweight (Karshya) as in the developing countries. It has been estimated that as many as two third of the world population suffer by under nutrition. According to Ayurvedic classics Vataja Prakriti person has lean body constitution and there is continuous degradation and aggradations in the body (Chakrapani Tika). So in person of Vataja Prakriti this phenomenon of degradation will lead to undernourishment thus resulting in difficulty for the person to cope with requirements of his life and falling prey to many disease even death.
Aims and objectives: To study the effect of oral administration of “Tila Taila” in Karshya person. To include “Tila Taila” in the food for well-being of the person.
Materials and Method:
The study was carried out in 80 individuals of Karshya, which were divided into 2 Groups. Group A having 35 persons were treated with Tila taila and Group B having 37 persons were treated with Mahish ghrita.
Result & Observations:
It was found that Group A i.e. treatment with Tila taila showed highly significant results in BMI followed by Group B showing significant results in serum cholesterol. Percentage of relief in symptoms was better in Group A but statistically both group shows significant result separately.
Maximum individuals i.e. 25% are with weight gain between 0.6 1kg. Mean change in serum cholesterol in Group A was 8.45 and in Group B was 18.27 and p value was 0.0001. Mean change in BMI in Group A was 0.43 and in Group B was 0.29 and p value was <0.05.
PMCID: PMC3800882
11.  Effect of Anuvasana Basti with Ksheerabala Taila in Sandhigata Vata (Osteoarthritis) 
Ayu  2014;35(2):148-151.
Osteoarthritis (OA) is the most common joint disorder. In Ayurveda the disease Sandhigata Vata resembles with OA, which is described under Vatavyadhi. Treatment provides symptomatic relief, but the underlying pathology remains unchecked due to the absence of effective drugs. In the management of Sandhigata Vata, all the Acharyas have described the employment of Bahya Snehan, Swedana, Abhyantara Tikta Snehapana, Basti treatment and Guggulu Prayoga.
To evaluate the effect of Ksheerbala Taila Anuvasana Basti in Sandhigata Vata
Materials and Methods:
In the present study, 30 patients of Sandhigata Vata were given Anuvasana Basti with Ksheerabala Taila. Subjective assessment of pain by visual analog scale and swelling, tenderness, crepitus and walking velocity were graded according to their severity.
Significant results (P < 0.05) were found in all the cardinal symptoms – Pain (Sandhiruja), Swelling (Shotha), tenderness, crepitus and walking velocity. Radiological findings showed no significant changes.
Anuvasana Basti with Ksheerabala Taila was significant in the subjective symptoms of Sandhigata Vata.
PMCID: PMC4279320  PMID: 25558159
Anuvasana Basti; Ksheerabala Taila; Sandhivata
12.  Effect of Kumari Taila Uttar Basti on fallopian tube blockage 
Ayu  2010;31(4):424-429.
The present study was carried out to evaluate the role of Uttar Basti in tubal blockage, in order to establish it as a safer and cost-effective Ayurvedic treatment modality. The criteria for selection of patients and assessment of results were unilateral or bilateral tubal blockage diagnosed in hysterosalpingography (HSG). A total of 16 patients in the reproductive age group were registered for the study, with 62.50% unilateral and 37.50% bilateral tubal blockage. Fifteen patients completed the course of treatment. The patients with an evidence of active infection or chronic diseases were excluded. Kumari Taila was selected for its Vata Kapha Shamaka and Lekhana properties. The dose of Uttar Basti was 5 ml with duration of two consecutive cycles (six days of Uttar Basti in each cycle with an interval of three days in between). Uttar Basti was administered, after cessation of menstruation, to the screened patients, through hematological, urinary, and serological (HIV, VDRL, HBsAg) investigations. The tubal blockage was removed in 80% of the patients, and 40% of the patients had conceived within the follow-up period of two months. The results suggest that Uttar Basti is a highly significant treatment modality for tubal blockage, with no apparent complications.
PMCID: PMC3202247  PMID: 22048533
Tubal blockage; Uttar Basti; Kumari Taila;  HSG
13.  Efficacy of Virechana and Basti Karma with Shamana therapy in the management of essential hypertension: A comparative study 
Ayu  2013;34(1):70-76.
Considering high prevalence and the need to look for alternative medicine, essential hypertension was screened in light of Vata–Pitta Pradhana Rakta Pradoshaja Vikara as mentioned by Acharya Charaka. Comparing the etiological factors, symptomatology, and complications with Rakta Pradoshaja Vikara with that of essential hypertension, a striking similarity was revealed. To prove the practical approach of management of Vata–Pitta Pradhana Rakta Pradoshaja Vikara, a randomized open clinical trial on 33 uncomplicated subjects of essential hypertension was conducted. The subjects were allotted in two groups, viz. (Group A) Virechana group having 16 cases who underwent Virechana Karma by Trivrita, Aragvadha, Eranda Taila, and Draksha Kwatha as Sahapana; and (Group B) Basti group consisting of 17 cases who were administered Dashmoola Kala Basti in which Niruha with Dashmoola Kwatha and Anuvasana with Dashmoola Taila was done. Patients of both the groups were followed by Shamana Chikitsa (Arjunadi Ghanavati). The overall effect of the therapies on systolic and diastolic blood pressure showed that Virechana proved better relief (43.75%) as compared to Basti (29.41%). The response was encouraging and has created scope for further studies.
PMCID: PMC3764884  PMID: 24049408
Basti Karma; essential hypertension; Raktapradoshaja Vikara; Virechana Karma
14.  The effect of acupressure at the Sanyinjiao point (SP6) on primary dysmenorrhea in students resident in dormitories of Tabriz 
There are two types of primary dysmenorrhea (spasmodic and congestive) which differ from each other in terms of the occurrence time in menstrual cycle, pain quality and other symptoms. The present study aimed to determine the effect of acupressure at the Sanyinjiao point (SP-6) on severity of menstrual symptoms (primary outcome) and the duration of resting time as well as the number of ibuprofen consumption (secondary outcome) in the two types of primary dysmenorrhea.
This was a clustered randomized controlled trial on 72 eligible students residing in dormitories of public universities of Tabriz, Iran. Determining the type of primary dysmenorrhea using a Menstrual symptoms questionnaire (MSQ), 36 participants which suffered from each type of dysmenorrhea were enrolled from the four dormitories. The dormitories were randomly divided into intervention and control groups. No intervention was carried out at the first cycle. During the two next cycles, Sanyinjiao point of the subjects in the intervention group was pressed for twenty minutes at the time of pain. The subjects in both groups were allowed to consume ibuprofen, if needed. During these three cycles, the participants recorded and reported menstrual symptoms severity, duration of resting time and the number of the used ibuprofen.
The severity of menstrual symptoms and duration of resting time in the 2nd and 3rd cycles were significantly reduced more than control groups for both spasmodic and congestive types of primary dysmenorrhea. In addition, the aver-age numbers of ibuprofen pills taken by both intervention groups was significantly less than the control groups. There was no significant difference between the two intervention groups in terms of any of the outcomes.
Acupressure is effective on lowering the symptoms of dysmenorrhea and duration of resting time almost equally in both spasmodic and congestive types. Therefore, using this method either alone or along with other methods is recommended to treat dysmenorrhea.
PMCID: PMC3583102  PMID: 23450186
Dysmenorrhea; acupressure; complementary medicine; controlled randomized trial
15.  OA01.03. Emergency management of pakshaghata - A case study 
Ancient Science of Life  2013;32(Suppl 2):S3.
To form a classical Ayurvedic protocol for the management of pakshaghata
Pakshaghata, is a vatavyadhi. It can be correlated to the biomedical cerebrovascular condition called ‘stroke’. The lakshanas include, ruja, vakstambha, etc. It's types are kaphanubandha and pittanubandha. Even though pakshaghata is a vata vyadhi, and mentioned in the nanatmaja vataja vikaras of charaka, it is not a shuddha vataja condition. There is samsarga of Pitta and kapha, clearly mentioned by Susrutha and Madhava nidana. In all the above explanations it is clear that raktadushti leading to vata prakopa is the underlying cause of the disease. The management of pakshaghata being reported in this paper is a case of ischemic stroke. Patient manifested with In the initial stage, treatment followed was teeksha nasya karma, which is akephepakavat chikitsa line of treatment as mentioned by Acharya Susrutha and Astanga sangraha for the purpose of reversing mada, murcha or sanyasa which is the pittaavrita vata stage of the disease. Once reversal of initial stage of pittavrita vata was accomplished, mridu virechana karma, svedana, abhyanga and basti were done for treating kaphaja and vataja stage of the disease and restore dosha balance. Nasya 8 drops in each nostril, Virechana Gandharva Hasta Eranda Taila 1030ml+30ml Dugdha, Agni alepa, Basti Anuvasana 80ml Brihat saindhava taila, Niruha 500ml mahamanjistadi kashaya.
After the course of treatment which lasted 15 days there was considerable reversal of symptoms. The recovery was promising and worth documenting. The results and discussion will be presented during the presentation.
The above mentioned protocol to treat atyayika cases of pakshaghata is unique. The recovery was promising and worth documenting.
PMCID: PMC4147499
16.  Assessment of Lekhana Basti in the management of hyperlipidemia 
Ayu  2013;34(4):339-345.
Hyperlipidemia is highly prevalent and is closely related to coronary heart disease which is the most common cause of death. Raised cholesterol is estimated to be responsible for 18% of cerebrovascular disease and 56% of ischemic heart disease. Overall, these diseases account for about 4.4 million deaths (7.9% of the total). Based upon the etiological factors and symptom complexes, hyperlipidemia can be considered as a part of Medoroga. Being a Tikshna formulation, the treatment modality of Lekhana Basti is aimed basically for Apatarpana (emaciation) of the body, as Basti is the fastest Apatarpana. In the present clinical trial, a total of 22 patients were registered of whom 19 patients completed the course of the therapy. Under randomization, the registered patients were divided into two groups of which group A was treated with Lekhana Basti and group B was administered standard control drug, i.e., Triphala Guggulu, for 21 days. The results of the study revealed that in patients treated with Lekhana Basti, there was a decrease of about 4.99% in S. cholesterol, 9.13% in S. low density lipoprotein (LDL), and 0.36% in S. apolipoprotein B. Lekhana Basti was found to have significant effect in reducing the symptoms of Medodushti and in reduction of objective parameters like weight, body mass index (BMI), body fat percentage, body circumferences such as chest, abdomen, hip, pelvis, mid-thigh circumference, etc., and skin fold thickness as biceps, triceps, mid-arm, and abdominal skinfold thickness.
PMCID: PMC3968693  PMID: 24696569
Hyperlipidemia; Lekhana Basti; Triphala Guggulu
17.  Gokshuradi Vati and Dhanyaka-Gokshura Ghrita Matra Basti in the management of Benign Prostatic Hyperplasia 
Ayu  2012;33(4):547-551.
Benign Prostatic Hyperplasia (BPH) is a burning senile problem of elderly men and no definitive conservative cure is available. The present available surgical and minimal invasive methods have their own limitations. Hence, to find out a suitable Ayurvedic approach, an effort has been made towards the management of BPH, In this study, 32 selected patients of Mootraghata at par to BPH were divided into three groups randomly and treated accordingly. In group A, Gokshuradi compound (GC) Vati (GV) 500 mg was given three times a day with luke-warm water after food; while in group B, Dhanyaka-Gokshura Ghrita (DGG) as Matra Basti (MB) of 60 ml, once in a day, just after lunch and combined therapy of both formulations in group C was administered. Out of 32 patients, total 30 patients (10 in each group) were completed the treatment course of 21 days. In results, 54.09% improvement was seen in group C, 45.67% in group A and 47.99% in group B. The size of prostate gland was found reduced highly significant in group C. Hence, it is concluded that combined therapy of GV and DGG MB is beneficial without developing any adverse drug reactions and can be prescribed safely for Mootraghata (BPH).
PMCID: PMC3665207  PMID: 23723674
Benign prostatic hyperplasia; Dhanyaka-Gokshura Ghrita; Gokshuradi Vati; Matra Basti; Mootraghata
18.  Bian Zheng Lun Zhi as a Complementary and Alternative Treatment for Menstrual Cramps in Women with Dysmenorrhea: A Prospective Clinical Observation 
Background. Limited scientific evidence supports the positive effects of traditional Chinese medicine (TCM) for treating dysmenorrhea. Thus, an observation period of 3 months could verify the ancient indication that TCM treatments effectively alleviate menstrual cramps in women with primary dysmenorrhea or endometriosis. Methods. A prospective, nonrandomized study (primary dysmenorrhea and endometriosis groups) was conducted in women with dysmenorrhea for more than three consecutive menstrual cycles. All patients received TCM prescriptions based on bian zheng lun zhi theory 14 days before menstruation for a period of 12 weeks. Pain intensity was evaluated using a 10-cm visual analogue scale and two validated questionnaires (the Menstrual Distress Questionnaire and the World Health Organization Quality of Life questionnaire). Results. Of the initial 70 intent-to-treat participants, the women with dysmenorrhea reported significant alleviation of cramps during menstruation after the 12-week TCM treatment. Mixed model analysis revealed that TCM prescriptions were more effective in alleviating fatigue, hot flashes, dizziness, painful breasts, excitement, and irritability in the primary dysmenorrhea group (N = 36) than in the endometriosis group (N = 34). Conclusion. TCM prescriptions based on syndrome differentiation theory might be a potentially viable choice for treating painful menstruation and premenstrual symptoms after ruling out endometriosis.
PMCID: PMC4150457  PMID: 25202332
19.  Acupuncture to Treat Primary Dysmenorrhea in Women: A Randomized Controlled Trial 
We examined the effectiveness of acupuncture to reduce the severity and intensity of primary dysmenorrhea. A randomized controlled trial compared acupuncture with control acupuncture using a placebo needle. Eligible women were aged 14–25 years with a diagnosis of primary dysmenorrhea. Women received nine sessions of the study treatment over 3 months. The primary outcomes were menstrual pain intensity and duration, overall improvement in dysmenorrhea symptoms and reduced need for additional analgesia, measured at 3, 6 and 12 months from trial entry. A total of 92 women were randomly assigned to the intervention (acupuncture n = 46 and control n = 46). At 3 months although pain outcomes were lower for women in the acupuncture group compared with the control group, there was no significant difference between groups. Women receiving acupuncture reported a small reduction in mood changes compared with the control group, relative risk (RR) 0.72, 95% confidence interval (CI) 0.53–1.00, P = .05. Follow-up at 6 months found a significant reduction in the duration of menstrual pain in the acupuncture group compared with the control group, mean difference –9.6, 95% CI –18.9 to –0.3, P = .04, and the need for additional analgesia was significantly lower in the acupuncture group compared with the control group, RR 0.69, 95% CI 0.49–0.96, P = .03, but the follow-up at 12 months found lack of treatment effect. To conclude, although acupuncture improved menstrual mood symptoms in women with primary dysmenorrhea during the treatment phase, the trend in the improvement of symptoms during the active phase of treatment, and at 6 and 12 months was non-significant, indicating that a small treatment effect from acupuncture on dysmenorrhea may exist. In the study, acupuncture was acceptable and safe, but further appropriately powered trials are needed before recommendations for clinical practice can be made.
PMCID: PMC3140031  PMID: 21799683
20.  Effects of Wheat Germ Extract on the Severity and Systemic Symptoms of Primary Dysmenorrhea: A Randomized Controlled Clinical Trial 
Primary dysmenorrhea is one of the most common disorders in women and the main cause of absenteeism from work and school.
Considering the anti-inflammatory properties of wheat germ, the present study examined the effects of wheat germ extract on the severity and systemic symptoms of primary dysmenorrhea.
Patients and Methods:
This triple-blinded clinical trial was performed on 80 employed women in hospitals affiliated with Hamadan University of Medical Sciences (Hamadan, IR Iran). Subjects were allocated to two groups of 45 patients. Three 400-mg capsules of wheat germ extract or placebo were used daily٫ between the 16th day of the menstrual cycle to the fifth day of the next menstrual cycle for two consecutive months. Pain intensity was measured by a visual analogue scale thrice a day and a four-point verbal rating scale was employed to assess systemic symptoms.
Pain severity decreased only in the wheat germ extract group (P < 0.001) and there was no statistically significant change in the placebo group. In the wheat germ extract group, the pain severity decreased from 4.701 at baseline to 1.120 at the second cycle. The reduction in total scores of systemic symptoms of dysmenorrhea was statistically significant only in the wheat germ extract group (P < 0.001) and there was not a statistically significant change in the placebo group. It revealed statistically significant differences in systemic symptoms associated with dysmenorrhea including fatigue, headache, and mood swings in experimental group.
Wheat germ extract seems to be an effective treatment for dysmenorrhea and its systemic symptoms, probably because of its anti-inflammatory effects.
PMCID: PMC4222016  PMID: 25389490
Dysmenorrhea; Herbal Medicines; Wheat Germ
21.  Acupuncture as an Adjunct Treatment for Primary Dysmenorrhea: A Comparative Study 
Medical Acupuncture  2013;25(4):291-294.
Primary dysmenorrhea occurs 40%–50% in women of reproductive age. Acupuncture may assist treatment of menstrual pain.
This study compared the effects of the acupuncture program Chongmai, or Thoroughfare Vessel (TV), to sham acupuncture on primary dysmenorrhea.
The current authors selected 3 groups of 10 patients each with primary dysmenorrhea for this comparative, prospective longitudinal study. The first group was treated at the TV points, the second group underwent sham acupuncture, and the third group (control) did not receive any kind of acupuncture. All groups were allowed to use steroidal anti-inflammatory drugs (NSAIDs). Menstrual pain was measured using a visual analogue scale (VAS). The results were analyzed using a Student's-t test in GraphPad Prism 5.0. Acupuncture needles were applied at the following TV acupuncture points: (1) Gongsun (SP 4); (2) Qichong (ST30); (3) Neiguan (PC 6); and (4) Baihuanshu (BL 30), the metameric action point of the pelvic area. Electrical stimulation was applied through each needle at 120 Hz for 40 minutes.
TV acupuncture, sham acupuncture, and/or NSAIDs substantially reduced pain in all 10 patients in each respective group (100%). TV acupuncture treatment reduced the symptoms of primary dysmenorrhea, and symptoms were reduced for at least 6 months. Application of needles at simulated points away from the TV acupuncture program did not reduce pain significantly.
TV acupuncture treatment can reduce the symptoms of primary dysmenorrhea, and the effect can last for 6 months.
PMCID: PMC3746293  PMID: 24761179
Primary Dysmenorrhea; Chongmai; Thoroughfare Vessel (TV); Sham Acupuncture; Pelvic Pain
22.  Role of ‘Krishna Tila’ and ‘Arkapushpa Taila’ Uttarbasti in the Management of Artavakshaya 
Ayu  2010;31(1):76-79.
Ayurvedic classics give importance to Shuddha Artava and mention that Artavadushti is one of the causative factors for infertility. Artavakshaya is not separately described as disease any where in Ayurvedic classics, of course, this doesn’t desecrate Artavakshaya. Because, Acharya Charaka has quoted in Charaka Nidana Sthana, first chapter, that symptoms of a disease themselves also constitute as a disease. But sometime, because of their subordinate nature they are only symptoms and not disease. This quotation substantiates the stand of taking ‘Artavakshaya’ as disease in the present studies. There are many processes and methods available in Ayurvedic classics to alleviate Artavakshya. But it is yet, the on going research to find out a method of treatment, which is nearer to procurance of permanent cure without side effects. It is well known that Ayurvedic classics emphasize on both Shodhana and Shamana therapy. Since Vata plays key role in Yoniroga, Uttarbasti, being Vata shamana, is a specific treatment in diseased condition of Yoni. As Shamana therapy Kwatha preparation choose to evaluate its efficacy. In the present study total 37 patients were registered, out of them 6 patients were discontinued. One group of patients was administered Arkapushpa Taila Uttarbasti and Krishna Tila Kwatha simultaneously. It gave more significant result. Krishna Tila Kwatha was administered orally in other group. Placebo wheat powder was administered orally in third group. Uttarbasti and Kwatha were found highly effective when administered simultaneously.
PMCID: PMC3215327  PMID: 22131689
Artavakshaya; Krishna Tila; Arkapushpa Taila; Oligomenorrhoea; Hypomenorrhoea; Secondary amenorrhoea
23.  Primary dysmenorrhea: prevalence in adolescent population of Tbilisi, Georgia and risk factors 
The study aimed to determine the prevalence of dysmenorrhea in female adolescents living in Tbilisi, Georgia; find possible risk factors and establish an association, if any, with nutrition and sleep hygiene.
Material and Methods
A cross-sectional study was used. A retrospective case control study was used to identify risk factors. Participants: A total of 2561 women consented to participate in the research. 431 participants were included in the case-control study. Interventions: Detailed questionnaire included: reproductive history, demographic features, menstrual pattern, severity of dysmenorrhea and associated symptoms; information about nutrition and sleep hygiene.
The prevalence of dysmenorrhea was 52.07%. Due to pain, 69.78% reported frequent school absenteeism. The risk of dysmenorrhea in students who had a family history of dysmenorrhea was approximately 6 times higher than in students with no prior history. The prevalence of dysmenorrhea was significantly higher among smokers compared with non-smokers 3.99% vs. 0.68% (p=.0.05 OR:6.102). Those women reporting an increased intake of sugar reported a marked increase of dysmenorrhea compared to women reporting no daily sugar intake (55.61% vs. 44.39%, p=.0023 LR:0.0002). However, alcohol, family atmosphere and nationality showed no correlation with dysmenorrhea. Our study revealed two most important risk factors of dysmenorrhea: meal skipping 59.78% vs. 27.03%, p=.00000 LR: 0.00000 OR:4.014 and sleep hygiene-receiving less sleep 38.77% vs. 19.59%, p=0.000055 LR: 0.000036 OR:2.598.
Primary dysmenorrhea is a common problem in the adolescent population of Tbilisi Geogia. It adversely affects their educational performance. Meal skipping and sleep quantity are associated with dysmenorrhea and may cause other reproductive dysfunctions.
PMCID: PMC3939234  PMID: 24592031
Primary dysmenorrhea; adolescent; nutrition; sleep; lifestyle
24.  The impact of a novel herbal Shirazi Thymus Vulgaris on primary dysmenorrhea in comparison to the classical chemical Ibuprofen 
Primary dysmenorrhea is defined as painful cramps during menstruation with no pelvic pathology. Due to the adverse effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are considered as the most common pharmacological treatment for this disorder. The present study was conducted to assess the impact of Shirazi Thymus Vulgaris compared to that of Ibuprofen on primary dysmenorrhea.
Materials and Methods:
A randomized, single-blind clinical trial was conducted amongst 120 female students ofIlam University of Medical Sciences, aged 18-25 years who suffered from primary dysmenorrhea. The participants were randomly divided into two groups; one received the herbal and the other classical treatments. The herbal group received 5 ml of the Shirazi Thymus Vulgaris medication that commercially called BronchoT.D, orally four times a day. The classic group received Ibuprofen orally three times a day. A visual analogue scale (VAS) was used to record pain severity.
Pain severity was reduced in both herbal and classic groups with no significant differences. Pain duration at the first and second month of treatment was also similar between two groups.
Shirazi Thymus Vulgaris decreased dysmenorrhea symptoms, which might be attributed to its antispasmodic effects. The herbal Shirazi Thymus Vulgaris can be recommended as an effective medication fortreatment of the primary dysmenorrhea disorder.
PMCID: PMC3685784  PMID: 23798928
Ibuprofen; primary dysmenorrheal; ShiraziThymus Vulgaris
25.  PA03.07. A clinical comparative study of Matra Vasti and Vaitran Vasti in the treatment of Gridhrasi w.s.r to Sciatica 
Ancient Science of Life  2013;32(Suppl 2):S76.
Sciatica is a vata dominant vikar and vasti is a vata dominant chikitsa. Matra Vasti is a nirapad vasti and can be given in any condition without following the ahara and vihara, then what is need for Vaitran Vasti? So, here an effort was made to study the effect of Matra vasti and Vaitran Vasti separately in the treatment of Grihdrasi.
30 patients were randomly selected from the OPD and IPD of Kayachikitsa Department of Ayurvedic Medical College,Davanagere, Karnataka and were separated in two groups of 15 each,and a study was conducted. Along with vasti chikitsa oral medication was also given. Ekangvir rasa in the dose of 500mg B.D and Lashunadi vati in the dose of 2 tabs. B.D.
Results were evaluated on the basis of symptoms of types of Gridhrasi i.e vataja and vatakaphaja as mentioned in Charak Samhita which showed marked improvement in all the symptoms. A Ttest was performed which gave a significant result of (P<.001). Results were also seen on the basis of International Scale which resulted in improvement in functional ability and reduction in functional disability.
It can be said that Vasti plays an important role in the treatment of Grihdrasi. In Vataja type Matra Vasti had played an supreme role as it helps in treating degenerative pathology and in Vatakaphaja type Vaitran Vasti had played a first rate role as it helps in treating inflammatory pathology.
PMCID: PMC4147550

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