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1.  Redetermination of loperamide monohydrate 
The structure of the title compound {systematic name: 4-[4-(4-chloro­phen­yl)-4-hy­droxy­piperidin-1-yl]-N,N-dimethyl-2,2-di­phenyl­butanamide monohydrate}, C29H33ClN2O2·H2O, has been redetermined at 170 (2) K. The redetermination is of significantly higher precision than the previous structure determination at room temperature and includes the H-atom coordinates that were not included in the previous report [Germain et al. (1977 ▶). Acta Cryst. B33, 942–944]. It consists of a piperidin-1-yl ring in a distorted chair conformation, with the N,N-dimethyl-α,α-diphenyl­butyramide and the 4-chloro­phenyl and hy­droxy groups bonded in para positions and an external water mol­ecule within the asymmetric unit. The dihedral angles between the mean plane of the piperidine ring and the 4-chloro­phenyl and two benzene rings are 83.4 (5), 76.4 (2) and 85.9 (2)°, respectively. The two benzene rings are inclined to one another by 50.8 (6)°. In the crystal, mol­ecules are linked by O—H⋯O and O—H⋯N hydrogen bonds and weak C—H⋯O intermolecular interactions, forming an infinite two-dimensional network along [110].
doi:10.1107/S1600536812003091
PMCID: PMC3275278  PMID: 22347134
2.  7-Chloro-4-[(E)-2-(4-methoxy­benzyl­idene)hydrazin-1-yl]quinoline monohydrate 
The organic mol­ecule in the title hydrate, C17H14ClN3O·H2O, has a small but significant twist from planarity, as seen in the dihedral angle of 12.10 (17)° between the quinoline and benzene rings. The conformation about the C=N bond is E. Chains along the b axis are formed in the crystal structure aided by water–quinoline O—H⋯N (× 2) and hydrazone–water N—H⋯O hydrogen bonds. Layers of these chains stack along the a axis via C—H⋯π and π–π inter­actions [ring centroid–ring centroid distance = 3.674 (2) Å]. C—H⋯O inter­actions are also present.
doi:10.1107/S1600536810006598
PMCID: PMC2983656  PMID: 21580437
3.  2-[6-(4-Chloro­phen­yl)imidazo[2,1-b][1,3]thia­zol-2-yl]-N′-[(E)-4-meth­oxy­benzyl­idene]acetohydrazide 
In the imidazo[2,1-b][1,3]thia­zole group of the title compound, C21H17ClN4O2S, the dihedral angle between the thia­zole and imidazole rings is 1.9 (2)°. The mean plane of this group makes dihedral angles of 5.5 (2) and 39.9 (2)° with the benzene rings of the chloro­phenyl and meth­oxy­phenyl groups, respectively. The dihedral angle between these two benzene rings is 34.4 (2)°. In the crystal, mol­ecules are connected to each other by inter­molecular N—H⋯O hydrogen bonds along the b axis, generating a C(4) chain. Weak C—H⋯π inter­actions also occur.
doi:10.1107/S1600536810052359
PMCID: PMC3050215  PMID: 21522689
4.  2-Amino-4-(4-chloro­phen­yl)-5,6-dihydro­benzo[h]quinoline-3-carbonitrile–3-amino-1-(4-chloro­phen­yl)-9,10-dihydro­phenanthrene-2,4-dicarbonitrile (1/4) 
The asymmetric unit of the 1:4 title co-crystal of 2-amino-4-(4-chloro­phen­yl)-5,6-dihydro­benzo[h]quinoline-3-carbonitrile and 3-amino-1-(4-chloro­phen­yl)-9,10-dihydro­phenanthrene-2,4-dicarbonitrile, 0.2C20H14ClN3·0.8C22H14ClN3, has the atoms of the fused-ring system and those of the amino, cyano and chloro­phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl­ene linkage in the central ring. There are two independent overlapped mol­ecules in the asymmetric unit. In one independent mol­ecule, the two flanking aromatic rings are twisted by 24.4 (1)° and the ring of the chloro­phenyl substituent is twisted by 87.3 (1)° relative to the amino- and cyano-bearing aromatic ring. In the second mol­ecule, the respective dihedral angles are 26.1 (1) and 57.8 (1)°. The two independent mol­ecules are linked by N—H⋯N hydrogen bonds into dimers.
doi:10.1107/S1600536811040529
PMCID: PMC3247609  PMID: 22219914
5.  12-(4-Chloro­phen­yl)-9,9-dimethyl-9,10-dihydro-8H-benzo[a]xanthen-11(12H)-one 
The title compound, C25H21ClO2, was synthesized via the three-component coupling of 4-chloro­benzaldehyde, 2-naphthol and 5,5-dimethyl­cyclo­hexane-1,3-dione. The pyran ring adopts a boat conformation, while the cyclo­hexenone ring is in an envelope conformation. The 4-chloro­phenyl ring is almost perpendicular to the pyran ring [dihedral angle = 87.39 (1)°]. In the crystal, mol­ecules are connected by inter­molecular C—H⋯O hydrogen bonds.
doi:10.1107/S1600536810004125
PMCID: PMC2983494  PMID: 21580318
6.  Crystal structures of di­chlorido­palladium(II), -platinum(II) and -rhodium(III) complexes containing 8-(di­phenyl­phosphan­yl)quinoline 
8-(Di­phenyl­phosphan­yl)quinoline (Ph2Pqn) acts as an asymmetric bidentate ligand to form a planar five-membered chelate ring in the di­chlorido­palladium(II) and -platinum(II) complexes, (SP-4)-[MCl2(Ph2Pqn)] (M = Pd or Pt), as well as in the di­chlorido­rhodium(III) complex, (OC-6-32)-[RhCl2(Ph2Pqn)2]PF6.
The crystal structures of di­chlorido­palladium(II), -platinum(II) and -rhodium(III) complexes containing 8-(di­phenyl­phosphan­yl)quinoline, (SP-4)-[PdCl2(C21H16NP)], (1) [systematic name: di­chlor­ido­(8-di­phenyl­phosphanyl­quinoline)­palladium(II)], (SP-4)-[PtCl2(C21H16NP)]·CH2Cl2, (2) [systematic name: di­chlorido­(8-di­phenyl­phos­phanyl­quinoline)­platinum(II) dichlorometh­ane monosolvate], and (OC-6–32)-[RhCl2(C21H16NP)2]PF6·0.5CH2Cl2·0.5CH3OH, (3) [systematic name: cis-di­chlor­ido­bis­(8-di­phenyl­phosphanyl­quinoline)­rhodium(III) hexa­fluorido­phos­phate di­chloro­methane/­methanol hemisolvate] are reported. In these complexes, the phosphanyl­quinoline acts as a bidentate ligand, forming a planar asymmetrical five-membered chelate ring. The palladium(II) and platinum(II) complex mol­ecules in (1) and (2), respectively, show a typical square-planar coordination geometry and form a dimeric structure through an inter­molecular π–π stacking inter­action between the quinolyl rings. The centroid–centroid distances between the stacked six-membered rings in (1) and (2) are 3.633 (2) and 3.644 (2) Å, respectively. The cationic rhodium(III) complex in (3) has a cis(Cl),cis(P),cis(N) (OC-6–32) configuration of the ligands, in which two kinds of intra­molecular π–π stacking inter­actions are observed: between the quinolyl and phenyl rings and between two phenyl rings, the centroid–centroid distances being 3.458 (2) and 3.717 (2) Å, respectively. The PF6 − anion in (3) is rotationally disordered, the site occupancies of each F atom being 0.613 (14) and 0.387 (14). The CH2Cl2 and CH3OH solvent mol­ecules are also disordered and equal site occupancies of 0.5 are assumed.
doi:10.1107/S2056989015006076
PMCID: PMC4420072  PMID: 25995852
crystal structure; 8-quinolylphos­phane; stacking inter­action; geometrical structure; trans influence
7.  (E)-N′-[3-(4-Chloro­benzo­yloxy)benzyl­idene]pyridine-4-carbohydrazide acetic acid monosolvate monohydrate 
In the Schiff base mol­ecule of the title compound, C20H14ClN3O3·CH3COOH·H2O, the central benzene ring makes dihedral angles of 36.26 (7) and 27.59 (8)°, respectively, with the terminal chloro­phenyl and pyridine rings. In the crystal, the three components are linked by O—H⋯O, N—H⋯O, O—H⋯N and C—H⋯O hydrogen bonds into a double-tape structure along the a axis.
doi:10.1107/S1600536812017369
PMCID: PMC3344622  PMID: 22590384
8.  Decacarbonyl-1κ3 C,2κ3 C,3κ4 C-bis­[tris­(3-chloro­phen­yl)phosphine]-1κP,2κP-triangulo-triruthenium(0) monohydrate 
The asymmetric unit of the title triangulo-triruthenium compound, [Ru3(C18H12Cl3P)2(CO)10]·H2O, consists of one triangulo-triruthenium complex and one disordered water solvent molecule. Two of the 3-chloro­phenyl rings are disordered over two positions with refined site occupancies of 0.671 (3)/0.329 (3) and 0.628 (3)/0.372 (3). The water mol­ecule is disordered over two positions with refined site occupancies of 0.523 (7) and 0.477 (7). Two equatorial carbonyl groups have been substituted by the two monodentate phosphine ligands, leaving one equatorial and two axial carbonyl substituents on the two Ru atoms. The remaining Ru atom carries two equatorial and two axial terminal carbonyl ligands. In the crystal structure, mol­ecules are linked into columns along the a axis by inter­molecular C—H⋯Cl and C—H⋯O hydrogen bonds. The mol­ecular structure is stabilized by weak intra­molecular C—H⋯O hydrogen bonds.
doi:10.1107/S1600536810013838
PMCID: PMC2979284  PMID: 21579061
9.  4,5,8a-Triphenyl­perhydro­pyrimido[4,5-d]pyrimidine-2,7-dione monohydrate 
The title compound, C24H22N4O2·H2O, was synthesized by the trimethyl­chloro­silane-catalysed reaction between urea, benzaldehyde and acetophenone. The organic mol­ecule comprises two fused tetra­hydro­pyrimidinone rings with phenyl substituents at the 4- and 5-positions on the tetra­hydro­pyrimidinone rings and a third phenyl substituent at the ring junction 8-position. The 4- and 5-substituted phenyl rings are inclined at a dihedral angle of 22.72 (11)° to one another and make angles of 47.95 (7) and 65.76 (7)° with the third phenyl substituent. In the crystal structure, inter­molecular N—H⋯O contacts link pyrimido[4,5-d]pyrimidine mol­ecules into centrosymmetric dimers. Additional N—H⋯O and O—H⋯O hydrogen bonds involving the water mol­ecule generate a three-dimensional network.
doi:10.1107/S1600536810019525
PMCID: PMC2979643  PMID: 21579563
10.  {2-[(1,3-Benzo­thia­zol-2-yl)meth­oxy]-5-fluoro­phen­yl}(4-chloro­phen­yl)methanone 
The asymmetric unit of the title compound, C21H13ClFNO2S, contains two independent mol­ecules with similar conformations. In the mol­ecules, the thia­zole ring is essentially planar [maximum atomic deviations = 0.014 (4) and 0.023 (5) Å] and is oriented with respect to the fluoro­phenyl ring and chloro­phenyl rings at 9.96 (18) and 70.39 (18)° in one mol­ecule and at 7.50 (18) and 68.43 (18)° in the other; the dihedral angles between the fluoro­phenyl and chloro­phenyl rings are 64.9 (2) and 64.6 (2)°, respectively. Inter­molecular C—H⋯O and C—H⋯F hydrogen bonds stabilize the three-dimensional supra­molecular architecture. Weak C—H⋯π and π–π inter­actions [centroid–centroid distance = 3.877 (3) Å] lead to a criss-cross mol­ecular packing along the c axis.
doi:10.1107/S1600536813014621
PMCID: PMC3772451  PMID: 24046594
11.  6-(2-Chloro­benz­yl)-1-(4-chloro­phen­yl)-7-hy­droxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one 
The title compound, C19H15Cl2N3O2, was obtained by a one-step cyclo­condensation of 2-amino-1-(4-chloro­phen­yl)imidazoline with diethyl (2-chloro­benz­yl)malonate under basic conditions. In the crystalline state, the mol­ecule exists as the 7-hy­droxy-5-oxo tautomer. The dihedral angles between the fused imidazopyrimidine and aromatic chloro­phenyl and chloro­benzyl rings are 14.2 (1) and 70.7 (1)°, respectively. The conformation of the mol­ecule is influenced by the intra­molecular C—H⋯O and C—H⋯N hydrogen bonds, giving a nearly planar five-ring fused system [maximum deviation from the mean plane = 0.296 (2) Å]. In the crystal structure, strong inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into chains along the c axis. These chains are further stabilized by weak C—H⋯Cl and π–π inter­actions [centroid–centroid distance = 3.6707 (12) Å].
doi:10.1107/S160053681003919X
PMCID: PMC3009369  PMID: 21588948
12.  7-(4-Chloro­phen­yl)-9-phenyl-7H-pyrrolo[3,2-e]tetra­zolo[1,5-c]pyrimidine 
In the title compound, C18H11ClN6, the pyrrole, pyrimidine and tetra­zole rings form a nearly planar fused trihetrocyclic system with an r.m.s. deviation of 0.0387 (13) Å, to which the 4-chloro­phenyl group and the phenyl group are substituted at the 7 and 9 positions, respectively. The dihedral angles between the pyrrole ring and the 4-chloro­phenyl and phenyl rings are 32.1 (4) and 7.87 (7)°, respectively. In the crystal, weak inter­molecular C—H⋯N and C—H⋯Cl hydrogen bonds link the mol­ecules into a layer parallel to the (001) plane. The layers are further connected by π–π stacking inter­actions [centroid–centroid distances: 3.8413 (8) and 3.5352 (8) Å]. Intra­molecular C—H⋯N hydrogen bonds are also present.
doi:10.1107/S160053681000485X
PMCID: PMC2983688  PMID: 21580361
13.  1-(4-Chloro­phen­yl)piperazine-1,4-diium tetra­chlorido­zincate(II) monohydrate 
In the crystal structure of the title compound, (C10H15ClN2)[ZnCl4]·H2O, the Zn atom is coordinated by four Cl atoms in a tetrahedral geometry. The water mol­ecules and the 1-(4-chloro­phen­yl)piperazine-1,4-diium cations inter­act with the [ZnCl4]2− anions through O—H⋯Cl, N—H⋯Cl, N—H⋯O and C—H⋯Cl hydrogen bonds (five simple and one bifurcated). Inter­molecular π–π stacking inter­actions are present between adjacent aromatic rings of 1-(4-chloro­phenyl)­piperazine-1,4-diium cations (the centroid–centroid distance is 3.453 Å).
doi:10.1107/S1600536808016590
PMCID: PMC2961817  PMID: 21202751
14.  1-Isobutyl-4-meth­oxy-1H-imidazo[4,5-c]quinoline 
In the title compound, C15H17N3O, the 1H-imidazo[4,5-c]quinoline ring system is approximately planar, with a maximum deviation of 0.036 (1) Å. The C—N—C—C torsion angles formed between this ring system and the isobutyl unit are −99.77 (16) and 79.71 (17)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into chains along the c axis.
doi:10.1107/S1600536811031801
PMCID: PMC3200859  PMID: 22058955
15.  Hopeahainol C monohydrate 
In the structure of the title compound, C28H16O6·H2O [systematic name 3,11-bis(4-hydroxyphenyl)-4,12-dioxapentacyclo[8.6.1.12,5.013,17.09,18]octadeca-1(16),2,5(18),6,8,10,13(17),14-octaene-7,15-diol monohydrate], the hopeahainol C mol­ecule lies about an inversion center with the solvent water mol­ecule located on a crystallographic twofold axis. Hopeahainol C is an oligostillbenoid compound and was isolated from the bark of Shorea roxburghii G. Don. The five central fused rings are essentially planar with an r.m.s. deviation of 0.0173 (3) Å. The 4-hy­droxy­phenyl ring is twisted with respect to this plane, with the dihedral angle between the phenyl ring and the fused-ring system being 41.70 (10)°. The crystal features inter­molecular O—H⋯O hydrogen bonds. These inter­actions link the hopeahainol C mol­ecules into chains along the b axis. Water mol­ecules are located inter­stitially between the hopeahainol C mol­ecules linked by O(water)—H⋯O(hy­droxy) and O(hy­droxy)—H⋯O(water) hydrogen bonds. π–π inter­actions are also observed with centroid–centroid distances of 3.6056 (17) and 3.5622 (17) Å. Short O⋯O contacts [2.703 (2)–2.720 (3) Å] are also present in the crystal.
doi:10.1107/S1600536811017053
PMCID: PMC3120350  PMID: 21754780
16.  4-[(E)-(4-Hy­droxy-2-oxo-2H-chromen-3-yl)methyl­idene­amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one monohydrate 
In the title compound, C21H17N3O4·H2O, the coumarin ring system is almost planar (r.m.s. deviation = 0.002 Å) and makes dihedral angles of 1.50 (7) and 57.75 (7)° with the pyrazole and phenyl rings, respectively. The dihedral angle between the pyrazole and phenyl rings is 56.60 (9)°. The pyrazole ring adopts a twisted comformation. The mol­ecular conformation is stabilized by intra­molecular N—H⋯O and C—H⋯O hydrogen bonds, both of which form S(6) ring motifs. In the crystal, each water mol­ecule is linked to its adjacent organic mol­ecule via pairs of O—H⋯O hydrogen bonds. The packing is further consolidated by pairs of inter­molecular C—H⋯O hydrogen bonds, which link the mol­ecules into dimers; the dimers are stacked along the b axis.
doi:10.1107/S160053681003480X
PMCID: PMC2983131  PMID: 21587490
17.  4-{[(E)-(4-Chloro­phen­yl)methyl­idene]amino}-3-{2-[4-(2-methyl­prop­yl)phen­yl]eth­yl}-1H-1,2,4-triazole-5(4H)-thione 
The asymmetric unit of the title compound, C21H23ClN4S, contains nine crystallographically independent mol­ecules, labelled A to I. The orientation of the 2-[4-(2-methyl­prop­yl)phen­yl]ethyl unit with respect to the rest of the mol­ecule is significantly different in mol­ecules E, F, H and I compared to the other independent mol­ecules. The isobutyl group of mol­ecule B is disordered over two orientations, with occupancies of 0.764 (7) and 0.236 (7). The benzene rings of the chloro­phenyl and methyl­propyl­phenyl units form dihedral angles of 21.90 (11) and 71.47 (11)°, respectively, with the triazole ring in mol­ecule A [9.15 (11) and 80.37 (11)° in B, 7.14 (11) and 84.06 (11)° in C, 25.76 (11) and 76.59 (11)° in D, 13.68 (11) and 76.82 (10)° in E, 8.38 (11) and 69.77 (10)° in F, 30.34 (11) and 78.12 (11)° in G, 21.20 (11) and 71.58 (10)° in H, and 27.65 (11) and 65.23 (11)° in I]. In each independent mol­ecule, a C—H⋯S hydrogen bond is observed. The crystal packing is stabilized by N—H⋯S and C—H⋯S hydrogen bonds, and by C—H⋯π inter­actions involving the methyl­propyl­phenyl ring.
doi:10.1107/S160053680901650X
PMCID: PMC2969595  PMID: 21583109
18.  6-(4-Chloro­phen­yl)-2-isobutyl­imidazo[2,1-b][1,3,4]thia­diazole 
In the title compound, C14H14ClN3S, the imidazo[2,1-b][1,3,4]thia­diazole system is essentially planar, with a maximum deviation of 0.006 (2) Å. The dihedral angle between the imidazo[2,1-b][1,3,4]thia­diazole and chloro­phenyl rings is 5.07 (8)°. In the crystal, there are no classical hydrogen bonds but stabilization is provided by weak π–π [centroid–centroid distance = 3.5697 (11) Å] and C—H⋯π inter­actions.
doi:10.1107/S1600536810052621
PMCID: PMC3050343  PMID: 21522707
19.  2-Amino-4-(2-chloro­phen­yl)-7,7-di­methyl-5-oxo-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile hemihydrate 
The asymmetric unit of the title compound, C18H17ClN2O2·0.5H2O, contains two organic mol­ecules and one solvent water mol­ecule. In each organic mol­ecule, the cyclo­hexene ring adopts an envelope conformation with the C atom connecting the two methyl groups on the flap; the 4H-pyran ring is nearly planar [maximum deviation = 0.113 (3) Å in one mol­ecule and 0.089 (3) Å in the other mol­ecule] and is approximately perpendicular to the chloro­phenyl ring [dihedral angle = 86.43 (15)° in one mol­ecule and 89.73 (15)° in the other mol­ecule]. Inter­molecular N—H⋯N, N—H⋯O, O—H⋯O and O—H⋯Cl hydrogen bonding is present in the crystal.
doi:10.1107/S1600536812003807
PMCID: PMC3297884  PMID: 22412687
20.  2-(2,4-Dichloro­phen­yl)-9-phenyl-2,3-di­hydro­thieno[3,2-b]quinoline 
In the title compound, C23H15Cl2NS, the quinoline system is almost planar [r.m.s. deviation = 0.013 (2) Å]. The phenyl group is disordered over two positions with site occupancies of 0.55 and 0.45, and is oriented in a nearly perpendicular configuration to the quinoline ring [the dihedral angles between the quinoline ring and the major and minor disordered components of the phenyl ring are 81.8 (2) and 71.6 (2)°, respectively]. The dihydro­thiene ring adopts an envelope conformation. The dihedral angle between the chloro­phenyl ring and the quinoline system is 79.32 (1)°. In the crystal weak C—H⋯π inter­actions occur.
doi:10.1107/S1600536809025380
PMCID: PMC2977236  PMID: 21583489
21.  3-(4-Chloro­phenyl­sulfin­yl)-2,4,7-tri­meth­yl-1-benzo­furan 
In the title compound, C17H15ClO2S, the dihedral angle between the mean plane [r.m.s. deviation = 0.020 (2) Å] of the benzo­furan ring system and the mean plane [r.m.s. deviation = 0.011 (1) Å] of the 4-chloro­phenyl ring is 72.68 (6)°. In the crystal, mol­ecules are linked via pairs of C—H⋯π inter­actions into inversion dimers. These dimers are further packed by C—H⋯O hydrogen bonds into supra­molecular chains running along the a-axis direction. In addition, the crystal structure also exhibits π–π inter­actions between the 4-chloro­phenyl rings of adjacent mol­ecules [centroid–centroid distance = 4.094 (3) Å, inter­planar distance = 3.648 (3) Å and slippage = 1.656 (3) Å].
doi:10.1107/S160053681302117X
PMCID: PMC3884416  PMID: 24427025
22.  2-Amino-N-[3-(2-chloro­benzo­yl)-5-ethyl­thio­phen-2-yl]acetamide 
In the title compound, C15H15ClN2O2S, the 2-amino­acetamide N—C(=O)—C—N unit is approximately planar, with an r.m.s. deviation of 0.020 (4) Å. The central thio­phene ring makes dihedral angles of 7.84 (11) and 88.11 (11)°, respectively, with the 2-amino­acetamide unit and the 2-chloro­phenyl ring. An intra­molecular N—H⋯O hydrogen bond generates an S(6) ring motif. In the crystal, mol­ecules are linked by an N—H⋯O hydrogen bond and weak C—H⋯O inter­actions into a chain along the c axis. A C—H⋯π inter­action is also present.
doi:10.1107/S1600536812003261
PMCID: PMC3275284  PMID: 22347140
23.  1,3-Dibenzyl-2-(2-chloro­phen­yl)-4-methyl­imidazolidine 
In the title compound, C24H25ClN2, the methine, methyl­ene and methyl C atoms of the methyl-substituted imidazolidine ring are disordered over two sets of sites with a refined occupancy ratio of 0.834 (4):0.166 (4). Each disordered ring assumes an envelope conformation with an N atom as the flap. The pendant benzyl rings are oriented equatorially with respect to the imidazolidine ring. The chloro­phenyl ring is inclined to the mean plane of the four planar atoms of the major component of the imidazolidine ring by 76.27 (12)°. The dihedral angles between the chloro­phenyl ring and the two benzyl rings are 55.31 (9) and 57.50 (8)°; the dihedral angle between these latter rings is 71.59 (9)°. In the crystal, mol­ecules are linked by C—H⋯Cl inter­actions and a number of weak C—H⋯π inter­actions, involving all three aromatic rings, forming a three-dimensional structure.
doi:10.1107/S1600536812047575
PMCID: PMC3589010  PMID: 23476246
24.  Ethyl 4-anilino-2,6-bis­(4-chloro­phen­yl)-1-phenyl-1,2,5,6-tetra­hydro­pyridine-3-carboxyl­ate 
The title compound, C32H28Cl2N2O2, was synthesized by a multicomponent reaction of 4-chloro­benzaldehyde, aniline and ethyl aceto­acetate. The central 1,2,5,6-tetra­hydro­pyridine ring exhibits a distorted boat conformation and the two chloro­phenyl rings attached to the central ring at positions 2 and 6 are oriented in opposite directions. The two O atoms of the eth­oxy­carbonyl group are involved in intra­molecular N—H⋯O and C—H⋯O hydrogen bonds. In the crystal, weak C—H⋯O hydrogen bonds link mol­ecules related by translation along the b axis into chains.
doi:10.1107/S1600536813013573
PMCID: PMC3685090  PMID: 23795109
25.  (E)-N′-(2-Chloro-5-nitro­benzyl­idene)-3-meth­oxy­benzohydrazide monohydrate 
In the hydrazone mol­ecule of the title compound, C15H12ClN3O4·H2O, the two benzene rings form a dihedral angle of 3.6 (1)°. In the crystal structure, the solvent water mol­ecules are involved in the formation of inter­molecular N—H⋯O and O—H⋯N hydrogen bonds, which link the mol­ecules into double ribbons extending along the b axis. Inter­molecular π–π inter­actions between the aromatic rings [centroid–centroid distances = 3.712 (3) and 3.672 (3) Å] link these ribbons further into layers parallel to the ab plane.
doi:10.1107/S1600536811020769
PMCID: PMC3151800  PMID: 21837031

Results 1-25 (113166)