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2.  Revision, cladistic analysis and biogeography of Typhochlaena C. L. Koch, 1850, Pachistopelma Pocock, 1901 and Iridopelma Pocock, 1901 (Araneae, Theraphosidae, Aviculariinae)  
ZooKeys  2012;1-94.
Three aviculariine genera endemic to Brazil are revised. Typhochlaena C. L. Koch, 1850 is resurrected, including five species; Pachistopelma Pocock, 1901 includes two species; and Iridopelma Pocock, 1901, six species. Nine species are newly described: Typhochlaena amma sp. n., Typhochlaena costae sp. n., Typhochlaena curumim sp. n., Typhochlaena paschoali sp. n., Pachistopelma bromelicola sp. n., Iridopelma katiae sp. n., Iridopelma marcoi sp. n., Iridopelma oliveirai sp. n. and Iridopelma vanini sp. n. Three new synonymies are established: Avicularia pulchra Mello-Leitão, 1933 and Avicularia recifiensis Struchen & Brändle, 1996 are junior synonyms of Pachistopelma rufonigrum Pocock, 1901 syn. n., and Avicularia palmicola Mello-Leitão, 1945 is a junior synonym of Iridopelma hirsutum Pocock, 1901 syn. n. Pachistopelma concolor Caporiacco, 1947 is transferred to Tapinauchenius Ausserer, 1871, making the new combination Tapinauchenius concolor (Caporiacco, 1947) comb. n. Lectotypes are newly designed for Pachistopelma rufonigrum Pocock, 1901 , Iridopelma hirsutum Pocock, 1901 and Pachistopelma concolor Caporiacco, 1947. Cladistic analyses using both equal and implied weights were carried out with a matrix comprising 62 characters and 38 terminal taxa. The chosen cladogram found with X-Pee-Wee and concavity 6 suggests they are monophyletic. All species are keyed and mapped and information on species habitat and area cladograms are presented. Discussion on biogeography and conservation is provided.
PMCID: PMC3494022  PMID: 23166476
Brazilian Atlantic rainforest; bromeliads; campo rupestre; cerrado; endemism; new species; restinga; systematics; tarantula
8.  Sir Ian Fraser 1901-1999 
The Ulster Medical Journal  1999;68(2):49-53.
Ian Fraser died at his residence, 19 Upper Malone Road, on 11th May in his ninety-ninth year. He had been a significant force in Ulster surgery, indeed the entire Ulster medical scene, almost from his appointment as an ‘honorary attending surgeon in charge of the out-patient department’ at the then Belfast Hospital for Sick Children (in Queen Street) in 1927 until late in life; and he was to receive wide national and international recognition. An acute sense of history was not the least of his gifts and all writers on local medical history owe much to his perceptive sketches of predecessors and earlier contemporaries.
A memorial service was held in Fisherwick Church on 2nd July. The family honoured me in their invitation to give a Tribute - which is reproduced below. I have added some notes which with standard reference sources, Ian's own autobiographical sketches, the Fraser Archive in the Archivist's office at RVH and other material preserved by his son, will I hope, provide sufficient background information to tempt the future biographer whom Fraser's life so richly deserves.
PMCID: PMC2449127
10.  William Thomas Salter (1901-1952) 
PMCID: PMC2599291  PMID: 13006414
12.  Regulation (EC) No 1901/2006 on medicinal products for paediatric use & clinical research in vulnerable populations 
Before any medicinal product is authorised for use in adults, it must undergo extensive pharmaceutical consistency and stability tests, toxicological tests and clinical trials to ensure that it is of high quality, safe and effective.
The same approach may not always be applied to medicinal products used to treat children.
Studies showed that over 50% of the medicinal products used in children may not have been tested for use in this age group. The absence of suitable authorised medicinal products to treat conditions in children results from the fact that pharmaceutical companies do not adapt medicinal products to the needs of the paediatric population. This leaves health care professionals with no alternative other than to use medicinal products "off-label" and to use unauthorised products with the associated risks of inefficacy and/or adverse reactions.
The Regulation (EC) No 1901/2006 sets up a system of requirements, rewards and incentives, together with horizontal measures, to ensure that medicinal products are researched, developed and authorised to meet the therapeutic needs of children.
The Regulation is addressed to:
1. The pharmaceutical industry by setting out the legal framework for receiving rewards and incentives by conducting clinical trials in the paediatric population.
2. The Member States to set out to support research into, and the development and availability of, medicinal products for paediatric use.
3. The Community as funds for research into medicinal products for the paediatric population shall be provided for in the Community budget in order to support studies relating to medicinal products or active substances not covered by a patent or a supplementary protection certificate.
The legal framework for conducting clinical trials, including children/minors, is set up in Directive 2001/20/EC, the Clinical Trials Directive (CTD), for the European Union (EU). The CTD establishes specific provisions regarding conduct of clinical trials, including multi-centre trials, on human subjects involving medicinal products and in particular relating to the implementation of good clinical practice. Compliance with this good practice provides assurance that the rights, safety and well-being of trial subjects are protected, and that the results of the clinical trials are credible. The CTD is addressed to all investigators conducting clinical trials including clinical trials in the paediatric population and had to be applied accordingly.
In the framework of the authorisation of medicinal products regulated by the Regulation (EC) No 726/2004 and Directive 2001/83/EC as amended and the CTD, and additional implementing Directives and guidelines, the new Regulation (EC) No 1901/2006 is an important new piece of legislation focusing on the requirements to improve the situation for the paediatric population.
All Regulations/Directives to be found:
PMCID: PMC2633263  PMID: 19063722
13.  Philip Rarick Edwards 1901-1966. 
Journal of Bacteriology  1966;92(3):531-535.
PMCID: PMC276285  PMID: 5332076
15.  JOHN JOYCE KEEVIL (1901–1957) 
Medical History  1958;2(2):142-143.
PMCID: PMC1034373  PMID: 13526545
18.  Hyla Bristow Stallard, 1901 to 1973 
PMCID: PMC1017335
19.  SUPPLEMENT 1901 
British Medical Journal  1941;1(4191):S53-S56.
PMCID: PMC2161819

Results 1-25 (4823)