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1.  The importance of leukotrienes in airway inflammation in a mouse model of asthma 
The Journal of Experimental Medicine  1996;184(4):1483-1494.
Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma. We employed a model of late-phase allergic pulmonary inflammation in mice to address the role of leukotrienes (LT) in mediating airway eosinophilia and hyperreactivity to methacholine. Allergen intranasal challenge in OVA-sensitized mice induced LTB4 and LTC4 release into the airspace, widespread mucus occlusion of the airways, leukocytic infiltration of the airway tissue and broncho-alveolar lavage fluid that was predominantly eosinophils, and bronchial hyperreactivity to methacholine. Specific inhibitors of 5- lipoxygenase and 5-lipoxygenase-activating protein (FLAP) blocked airway mucus release and infiltration by eosinophils indicating a key role for leukotrienes in these features of allergic pulmonary inflammation. The role of leukotrienes or eosinophils in mediating airway hyperresponsiveness to aeroallergen could not be established, however, in this murine model.
PMCID: PMC2192843  PMID: 8879219
2.  Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation 
Respiratory Research  2015;16(1):77.
Background
Potential involvement of the CCR10/CCL28 axis was recently reported in murine models of allergic asthma. If confirmed, blockade of the CCR10 receptor would represent an alternative to current asthma therapies. We evaluated the effect of a novel Protein Epitope Mimetic CCR10 antagonist, POL7085, in a murine model of allergic eosinophilic airway inflammation.
Methods
Mice were sensitized and challenged to ovalbumin. POL7085, a CCR10 antagonist (7.5 and 15 mg/kg), dexamethasone (1 mg/kg) or vehicle were administered intranasally once daily 1h before each allergen challenge. On day 21, airway hyperresponsiveness, bronchoalveolar lavage inflammatory cells and Th2 cytokines, and lung tissue mucus and collagen were measured.
Results
Allergen challenge induced airway hyperresponsiveness in vehicle-treated animals as measured by whole body barometric plethysmography, and eosinophilia in bronchoalveolar lavage. POL7085 dose-dependently and significantly decreased airway hyperresponsiveness (34 ± 16 %) and eosinophil numbers in bronchoalveolar lavage (66 ± 6 %). In addition, the highest dose of POL7085 used significantly inhibited lung IL-4 (85 ± 4 %), IL-5 (87 ± 2 %) and IL-13 (190 ± 19 %) levels, and lung collagen (43 ± 11 %).
Conclusions
The Protein Epitope Mimetic CCR10 antagonist, POL7085, significantly and dose-dependently decreased allergen-induced airway hyperresponsiveness and airway inflammation after once daily local treatment. Our data give strong support for further investigations with CCR10 antagonists in asthmatic disease.
Electronic supplementary material
The online version of this article (doi:10.1186/s12931-015-0231-5) contains supplementary material, which is available to authorized users.
doi:10.1186/s12931-015-0231-5
PMCID: PMC4490744  PMID: 26112287
CCR10; CCL28; Asthma; Airway hyperresponsiveness; Inflammation; Mouse; Allergen; Ovalbumin; Eosinophilia
3.  Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression 
The Journal of Experimental Medicine  2001;193(11):1247-1260.
Recent studies in transgenic mice have revealed that expression of a dominant negative form of the transcription factor GATA-3 in T cells can prevent T helper cell type 2 (Th2)-mediated allergic airway inflammation in mice. However, it remains unclear whether GATA-3 plays a role in the effector phase of allergic airway inflammation and whether antagonizing the expression and/or function of GATA-3 can be used for the therapy of allergic airway inflammation and hyperresponsiveness. Here, we analyzed the effects of locally antagonizing GATA-3 function in a murine model of asthma. We could suppress GATA-3 expression in interleukin (IL)-4–producing T cells in vitro and in vivo by an antisense phosphorothioate oligonucleotide overlapping the translation start site of GATA-3, whereas nonsense control oligonucleotides were virtually inactive. In a murine model of asthma associated with allergic pulmonary inflammation and hyperresponsiveness in ovalbumin (OVA)-sensitized mice, local intranasal administration of fluorescein isothiocyanate–labeled GATA-3 antisense oligonucleotides led to DNA uptake in lung cells associated with a reduction of intracellular GATA-3 expression. Such intrapulmonary blockade of GATA-3 expression caused an abrogation of signs of lung inflammation including infiltration of eosinophils and Th2 cytokine production. Furthermore, treatment with antisense but not nonsense oligonucleotides induced a significant reduction of airway hyperresponsiveness in OVA-sensitized mice to levels comparable to saline-treated control mice, as assessed by both enhanced pause (PenH) responses and pulmonary resistance determined by body plethysmography. These data indicate a critical role for GATA-3 in the effector phase of a murine asthma model and suggest that local delivery of GATA-3 antisense oligonucleotides may be a novel approach for the treatment of airway hyperresponsiveness such as in asthma. This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine.
PMCID: PMC2193377  PMID: 11390432
GATA-3; antisense DNA; asthma; T cells; Th2 cytokines
4.  Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation 
Summary
Background
Identifying therapeutic drugs that block the release or effects of T-helper type 2 (Th2) cytokines after allergen exposure is an important goal for the treatment of allergic inflammatory diseases including asthma. We recently showed, using a murine model of allergic airway inflammation, that poly(ADP-ribose) polymerase (PARP) plays an important role in the pathogenesis of asthma-related lung inflammation. PARP inhibition, by single injection of a novel inhibitor, thieno[2,3-c]isoquinolin-5-one (TIQ-A), before ovalbumin (OVA) challenge, prevented airway eosinophilia in C57BL/6 mice with concomitant suppression of Th2 cytokine production and mucus secretion.
Objective
To evaluate the efficacy of the drug when it is given after OVA challenge for its possible therapeutic potential.
Methods
This study was conducted using a murine model of allergic airway inflammation.
Results
A single injection of TIQ-A (6 mg/kg) one or 6 h post-allergen challenge conferred similar reduction in OVA challenge-induced eosinophilia. More significantly, post-allergen challenge administration of the drug exerted even better suppression on the production of IL-4, IL-5, IL-13, and IgE and prevented airway hyperresponsiveness to inhaled-methacholine. The significant decrease in IL-13 was accompanied by a complete absence of airways mucus production indicating a potential protection against allergen-induced airway remodelling.
Conclusion
The coincidence of the inflammation trigger and the time of drug administration appear to be important for the drug’s more pronounced protection. The observed time window for efficacy, 1 or 6 h after allergen challenge may be of great clinical interest. These findings may provide a novel therapeutic strategy for the treatment of allergic airway inflammation, including asthma.
doi:10.1111/j.1365-2222.2008.02943.x
PMCID: PMC2740645  PMID: 18261157
airway hyperresponsiveness; allergy; cytokines; eosinophils; inflammation; interleukin; lung; mucus; PARP; therapeutic potential
5.  XXIV World Allergy Congress 2015 
Lee, Heung-Man | Park, Il-Ho | Shin, Jae-Min | Yoon, Hyun-Sun | Park, Gyeong Yul | Zeher, Margit | Matsui, Katsuhiko | Tamai, Saki | Ikeda, Reiko | Suri, Drsushil | Suri, Dranu | Arani, Marzieh Heidarzadeh | Lubis, Azwin | Endaryanto, Anang | Koga, Shinichiro | Suk, Lee Ju | Tsuzuki, Yasunobu | Kim, Seo Hyeong | Shin, Jung U. | Noh, Ji Yeon | Jin, Shan | Jin, Shan | Lee, Hemin | Lee, Jungsoo | Park, Chang Ook | Lee, Kwang Hoon | Lee, Kwang Hoon | Tepetam, Fatma Merve | Park, Chun Wook | Son, Jee Hee | Cho, Soo Ick | Cho, Yong Se | Byun, Yun Sun | Yang, Yoon Seok | Chung, Bo Young | Kim, Hye One | Cho, Hee Jin | Katada, Yoshinori | Tanaka, Toshio | Nakabayashi, Akihiko | Nishida, Koji | Aoyagi, Kenichi | Tsukamoto, Yuki | Konma, Kazushi | Matsuura, Motoo | Park, Jung-Won | Harada, Yoshinori | Jeong, Kyoung Yong | Yura, Akiko | Yoshimura, Maiko | Kyung, Tae-Suk | Kim, Young Hyo | Park, Chang-Shin | Jang, Tae Young | Heo, Min-Jeong | Jung, Ah-Yeoun | Yang, Seung-Chan | Kim, Hye One | Cho, Yong Se | Byun, Yun Sun | Yang, Yoon Seok | Chung, Bo Young | Son, Jee Hee | Park, Chun Wook | Cho, Hee Jin | Pfaar, Oliver | Sager, Angelika | Agarwal, Amit | Singh, Meenu | Chatterjee, Bishnupda | Chauhan, Anil | Striz, Ilja | Cecrdlova, Eva | Petrickova, Katerina | Kolesar, Libor | Sekerkova, Alena | Svachova, Veronika | Petricek, Miroslav | Kwon, Hyuck Hoon | Kim, Kyu Han | Kumar, Suman | Manzon, Lou Ver Leigh Arciaga | Andaya, Pilar Agnes Gonzalez | Lew, Bark-Lynn | Oh, Youngjun | Suh, Dongwoo | Sim, Woo-Young | Jeong, Kyoung Yong | Yi, Myung-Hee | Son, Mina | Lyu, Dongpyo | Lee, Jae-Hyun | Yong, Tai-Soon | Hong, Chein-Soo | Park, Jung-Won | Jeong, Kyoung Yong | Yi, Myung-Hee | Son, Mina | Lyu, Dongpyo | Lee, Jae-Hyun | Yong, Tai-Soon | Hong, Chein-Soo | Park, Jung-Won | Siavashi, Mohammadreza | Yun, Hey Suk | Kang, Ha-Na | Oh, Jae-Won | Choi, Young Jin | Oh, Jae-Won | Choi, Young Jin | Kang, Ha-Na | Sentsova, Tatiana | Vorozhko, Ilya | Chernyak, Olga | Revyakina, Vera | Timopheeva, Anna | Donnikov, Andrey | Sentsova, Tatiana | Vorozhko, Ilya | Chernyak, Olga | Revyakina, Vera | Timopheeva, Anna | Lee, Ji Hyun | Park, Young Min | Choi, Sang Soo | Han, Kyung Do | Jung, Han Mi | Youn, Young Hoon | Lee, Jun Young | Park, Yong Gyu | Lee, Seung-Hwan | Li, Jing | Feng, Mulin | Roponen, Marjut | Schaub, Bianca | Wong, Gary W. K. | Yang, Zhaowei | Choi, Young Jin | Kang, Ha-Na | Oh, Jae-Won | Sun, Baoqing | Zheng, Peiyan | Park, Yoon-Sung | Son, Sang Wook | Kose, Sukran | Kiraz, Kemal | Yalcin, Arzu Didem | Yune, Sehyo | Paeng, Jae-Won | Oh, Mi-Jung | Lee, Byung-Jae | Choi, Dong-Chull | Lim, Young Hee | Ha, Kyoung Won | Lee, Jin-Young | Yamamoto-Hanada, Kiwako | Narita, Masami | Futamura, Masaki | Ohya, Yukihiro | Kim, Jihyun | Choi, Jinwha | Kim, Kwanghoon | Choi, Jaehee | Ahn, Kangmo | Chang, Sun-Ho/Brian | Li, Lisha | Adachi, Yu-Ichi | Kanatani, Kumiko Tsuji | Narabayashi, Shigeyuki | Okafuji, Ikuo | Tanaka, Yuya | Tsuruta, Satoru | Takamatsu, Nobue | Kim, Soo Whan | Kim, Do Hyun | Yoon, Jong-Seo | Kim, Jin Tack | Kim, Hwan Soo | Chun, Yoon Hong | Kim, Hyun Hee | Won, Sul Mui | Hon, Kam Lun E. | Chow, Chung Mo | Leung, Ting Fan | Kim, Do Hyun | Kim, Soo Whan | Esguerra, Gemmalyn | Resurreccion, Emily | Kionisala, Kristine Elisa | Dela Cruz, Jenni Rose | Imran, Muhammad | Choe, Yun Seon | Kim, Kyu Han | Choi, Mira | Kim, Byung Soo | Lee, Hyun-Joo | Kim, Jeong-Min | Kim, Jeong-Min | Kim, Gun-Wook | Mun, Je-Ho | Mun, Je-Ho | Kim, Hoon-Soo | Song, Margaret | Ko, Hyun-Chang | Ko, Hyun-Chang | Kim, Moon-Bum | Yoon, Sun-Young | Kandhare, Amit | Yahiro, Noriko | Agarwal, Amit | Singh, Meenu | Kaur, Jasleen | Pawankar, Ruby | Pant, Pankaj | Singh, Sukhmanjeet | Kim, Hwan Soo | Yoon, Jong-Seo | Won, Sul Mui | Chun, Yoon Hong | Kim, Jin Tack | Kim, Hyun Hee | Kim, Hwan Soo | Won, Sul Mui | Chun, Yoon Hong | Yoon, Jong-Seo | Kim, Hyun Hee | Kim, Jin Tack | Kampitak, Thatchai | Kim, So Min | Lee, Hyun Joo | Kim, Hei Sung | Lee, Jeong Deuk | Cho, Sang Hyun | Godse, Kiran | Soekarno, Juwita | Ratnasari, Sarie | Datau, E. Alwi | Surachmanto, Eko | Matheos, JC | Leung, Ting Fan | Kwok, Jamie Sui-Lam | Tung, Christine Kit-Ching | Tang, Man Fung | Tsui, Stephen Kwok-Wing | Wong, Gary WK | Hon, Kam Lun Ellis | Tam, Wing Hung | Sy, Hing Yee | Lee, Sohee | Shin, Hyun-Woo | Lee, Mingyu | Kim, Dae Woo | Khalmuratova, Roza | Kim, Mi Yeoung | Jeong, Jaewon | Park, Chansun | Wai, Christine Yee Yan | Leung, Patrick S. C. | Leung, Nicki Y. H. | Chu, Ka Hou | Lee, Hee Seon | Lee, Kyung Eun | Hong, Jung Yeon | Kim, Mi Na | Kim, Min Jung | Kim, Yoon Hee | Sol, In Suk | Yoon, Seo Hee | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Kim, Ji Hye | Park, Hae-Sim | Shin, Yoo Seob | Ye, Young Min | Seo, Daehong | Yoon, Moon Gyeong | Lee, Young Mok | Seo, Daehong | Kim, Ji Hye | Lee, Young-Mok | Ye, Young Min | Park, Hae-Sim | Ban, Ga Young | Cho, Kumsun | Kim, Seung-Hyun | Kwon, Yong Eun | Yoon, Moon Gyeong | Kim, Ji Hye | Shin, Yoo Seob | Ye, Young Min | Nahm, Dong-Ho | Park, Hae-Sim | Andaya, Pilar Agnes Gonzalez | Andaya, Pilar Agnes Gonzalez | Ban, Ga Young | Jung, Chang Gyu | Lee, Seung-Ihm | Le Pham, Duy | Suh, Dong-Hyeon | Yang, Eun-Mi | Ye, Young Min | Shin, Yoo Seob | Park, Hae-Sim | Wang, Wan Jun | Xian, MO | Xie, Yan Qing | Zheng, Jing Ping | Li, Jing | Savilahti, Emma Merike | Mäkitie, Outi | Kukkonen, Anna Kaarina | Andersson, Sture | Viljakainen, Heli | Savilahti, Erkki | Kuitunen, Mikael | Godse, Kiran | Le Pham, Duy | Ban, Ga Young | Kim, Seung-Hyun | Yang, Eun-Mi | Park, Hae-Sim | Lee, Ji-Ho | Chwae, Yong-Joon | Chin, Li-Ming | Shieh, Chi-Chang | Kim, Ji Hye | Yoo, Hye-Soo | Yoon, Moon Gyeong | Ban, Ga Young | Ban, Ga Young | Shin, Yoo Seob | Ye, Young Min | Park, Hae-Sim | Sung, Myong Soon | Choi, Jin Uck | Kim, Sung Won | Hwang, Yong Jin | Park, Arum | Lee, Eun | Yang, Song-I | Cho, Hyun-Ju | Yu, Jinho | Lee, Dong Hun | Kim, Eun Ju | Kim, Yeon Kyung | Doh, Eun Jin | Eun, Hee Chul | Chung, Jin Ho | Lee, Young Mee | Jin, Seon Pil | Li, Xingnan | Kaminski, Naftali | Wenzel, Sally | Bleecker, Eugene | Meyers, Deborah | Huasong, Zeng | Mo, Ji-Hun | Samivel, Ramachandran | Kim, Eun-Hee | Kim, Ji-Hye | Bae, Jun-Sang | Chung, Young-Jun | Kim, Dae Woo | Lee, Eun | Lee, Si Hyeon | Kim, Young-Ho | Cho, Hyun-Ju | Yu, Ho-Sung | Kang, Mi-Jin | Yang, Song-I | Jung, Young-Ho | Kim, Hyung Young | Seo, Ju-Hee | Kim, Byoung-Ju | Kim, Hyo-Bin | Lee, So-Yeon | Kwon, Ho-Jang | Hong, Soo-Jong | Palikhe, Sailesh | Park, Hae-Sim | Kim, Seung-Hyun | Kim, Ji Hye | Yang, Eun-Mi | Sibunruang, Suda | Klaewsongkram, Jettanong | Sentsova, Tatiana | Vorozhko, Ilya | Timopheeva, Anna | Chernyak, Olga | Revyakina, Vera | Sokolnikov, Andrey | Nisihino, Makoto | Okada, Yu | Yanagida, Noriyuki | Ebisawa, Motohiro | Sato, Sakura | Ogura, Kiyotake | Asaumi, Tomoyuki | Nagakura, Kenichi | Manabe, Tetsuharu | Unno, Hirotoshi | Rodrigues, Pedro M. | Schrama, Denise | Mohamed, Gadija | Hüsselmann, Lizex | Hüsselmann, Lizex | Ndimba, Bongani | Shim, Jae-Uoong | Koh, Young Il | Rhee, Joon Haeng | Jeong, Ji-Ung | Van Nguyen, Dinh | Chu, Hieu Chi | Tran, Mui Thi | Vidal, Christopher | Fernando, Suran | Van Nunen, Sheryl | Van Than, Sy | Feng, Mulin | Li, Jing | Kim, Dong-Kyu | Hong, Seung-No | Eun, Kyoung Mi | Jin, Hong Ryul | Kim, Dae Woo | Bao, Jun | Bao, Yi-Xiao | Podder, Sanjoy | Kumar, Goutam | Dutta, Shampa | Ghosh, Amlan | Saha, Goutam Kumar | Podder, Sanjoy | Gupta, Salil Kumar | Trinh, Tu/Hoang Kim | Shin, Yoo Seob | Park, Hae-Sim | Liu, Jing-Nan | Le Pham, Duy | Ko, Hyun-Chang | Kim, Byung Soo | Kim, Moon-Bum | Özbudak, Ömer | Üzer, Fatih | Al-Ahmad, Mona | Alowayesh, Maryam | Carroll, Norman | Singh, Anand Bahadur | Pérez-Llano, Yordanis | Lorenzo, María Del Carmen Luzardo | González, Wendy Ramírez | Cruz, Carlos Calcines | Quintana, Rady Laborde | Morejón, Alain | Bourg, Virgilio | Stoker, Marilé Hechavarría | Bae, Jun-Sang | Samivel, Ramachandran | Kim, Eun-Hee | Kim, Ji-Hye | Mo, Ji-Hun | Hanaoka, Keiko | Hide, Michihiro | Tanaka, Akio | Hiragun, Makiko | Kawai, Mikio | Kim, Kwanghoon | Kim, Hye-Young | Kim, Jihyun | Ahn, Kangmo | Han, Youngshin | Kim, Gun-Wook | Ko, Hyun-Chang | Kim, Byung Soo | Kim, Moon-Bum | Song, Margaret | Matsubara, Takeshi | Iwamoto, Hiroshi | Nakazato, Yuki | Namba, Kazuyoshi | Takeda, Yasuhiro | Lee, Jae Hoon | Bae, Woo Yong | De Schryver, Els | Calus, Lien | Gevaert, Philippe | Van Zele, Thibaut | Bachert, Claus | Mori, Akio | Kouyama, Satoshi | Yamaguchi, Miyako | Iijima, Yo | Abe-Ohtomo, Akemi | Hayashi, Hiroaki | Watai, Kentaroh | Mitsui, Chihiro | Oshikata, Chiyako | Sekiya, Kiyoshi | Tsuburai, Takahiro | Ohtomo, Mamoru | Fukutomi, Yuma | Taniguchi, Masami | Kang, Ju Wan | Kim, Jeong Hong | Kim, Jeong Hong | Lee, Keun-Hwa | Lee, Hye-Sook | Hong, Seong-Chul | Lee, Jaechun | Seo, Ji Won | Lee, Jae Hoon | Bae, Woo Yong | Kuznecovs, Ivans Sergejs | Kuznecova, Galina | Bergmann, Karl-Christian | Zuberbier, Torsten | Salame, Joseph | Sehlinger, Torsten | Bölke, Georg | Kim, Yoo Suk | Chang, Jung Hyun | Kim, Jeong Hong | Kang, Ju Wan | Hong, Seung-No | Han, Doo Hee | Rhee, Chae-Seo | Ko, Young-Joo | Kim, Young Hyo | Kim, Dae-Young | Jang, Tae Young | Yokooji, Tomoharu | Hirano, Taiki | Matsuo, Hiroaki | Kuznecova, Galina | Kuznecovs, Ivans Sergejs | Wani, Roohi Rasool | Syed, Shafia Alam | Hassan, Ghulam | Gul, Ayaz | Nissar, Saniya | Shah, Zaffar Amin | Pereira, Marilyn Urrutia | Fernandez, Carmen | Sole, Dirceu | Neto, Herberto Jose Chong | Acosta, Veronica | Cepeda, Alfonso Mario | Castello, Mirta Alvarez | Almendarez, Claudia | Saenz, Jose Santos Lozano | Sisul, Juan C. | Filho, Nelson Rosario | Castillo, Antonio | Rostan, Marylin Valentin | Avila, Jennifer | Badellino, Hector | Manotas, Maria Carolina | Almarales, Raúl Lázaro Castro | León, Mayda González | Kim, Woo Kyung | Yoon, Hae-Sun | Kobayashi, Takehito | Noguchi, Tooru | Soma, Tomoyuki | Nakagome, Kazuyuki | Nakamoto, Hidetomo | Kita, Hirohito | Nagata, Makoto | Pereira, Marilyn Urrutia | Sole, Dirceu | Neto, Herberto Jose Chong | Cepeda, Alfonso Mario | Almarales, Raúl Lázaro Castro | Sisul, Juan C. | Rostan, Marylin Valentin | Badellino, Hector | Avalos, Miguel Alejandro Medina | Castillo, Antonio | Almendarez, Claudia | Filho, Nelson Rosario | Silot, Caridad Sanchez | Avila, Jennifer | Rodriguez, Felicia Berroa | Saenz, Jose Santos Lozano | Castello, Mirta Alvarez | Fernandez, Carmen | Soh, Wai Tuck | Jacquet, Alain | Ruxrungtham, Kiat | Nony, Emmanuel | Le Mignon, Maxime | Lee-Wong, Mary | McClelland, Suzanne | McClelland, Suzanne | Silverberg, Nanette B. | Song, Christian E. | Yang, Zhaowei | Zhang, Jiukai | Zheng, Wentao | Zhong, Nanshan | Li, Jing | Bae, Jung Ho | Cho, Young Joo | Kim, Joo Yeon | Vourdas, Dimitrios | Grigoreas, Christos | Petalas, Konstantinos | Zhang, Yuan | Shin, Seung-Heon | Ye, Mi-Kyung | Kim, Jeong-Kyu | Feng, Yong | Shang, Yunxiao | Seo, Sungchul | Choung, Ji Tae | Kim, Dohyeong | Yoo, Young | Lim, Hyunwook | Zhu, Wenjing | Liu, Chuanhe | Sha, Li | Chang, Li | Zhao, Min | Zhao, Linqing | Qian, Yuan | Chen, Yuzhi | Kim, Min-Hye | Cho, Young Joo | Rho, Mina | Kim, Jung-Won | Kang, Yeon-Mi | Yum, Kyung-Eun | Choi, Hyeon-Il | Choi, Jun-Pyo | Park, Han-Ki | Min, Taek-Ki | Pyun, Bok-Yang | Kim, Yoon-Keun | Wang, Xueyan | Kim, Woo Kyung | Nam, Yu Ran | Nam, Joo Hyun | Kim, Jung-Won | Kim, Min-Hye | Rho, Mina | Kang, Yeon-Mi | Yum, Kyung-Eun | Choi, Hyeon-Il | Choi, Jun-Pyo | Park, Han-Ki | Min, Taek-Ki | Cho, Young Joo | Pyun, Bok-Yang | Kim, Yoon-Keun | Narita, Hiroshi | Hirose, Junko | Kizu, Kumiko | Matsunaga, Ayu | Li, Jingyun | Zhang, Yuan | Zhang, Luo | Choi, Yean Jung | Shin, Hye Lim | Yang, Song-I | Lee, So-Yeon | Kwon, Sung-Ok | Jung, Young-Ho | Kwon, Ji-Won | Kim, Hyung Young | Seo, Ju-Hee | Kim, Byoung-Ju | Kim, Hyo-Bin | Oh, Se-Young | Kwon, Ho-Jang | Lee, Eun | Kang, Mi-Jin | Hong, Soo-Jong | Lee, Yun-Jeong | Kim, Joonil | Choi, Joon Young | Kang, Ji Young | Kim, Seok Chan | Kim, Sei Won | Kim, Seung Joon | Kim, Young Kyoon | Rhee, Chin Kook | Lee, Hea Yon | Lee, Hwa Young | Lee, Sook Young | Koh, Tae Kyung | Kim, Sung Wan | Lee, Kun Hee | Kwon, Chul | Jo, Joong-Saeng | Dong, Sung-Hwa | Byun, Young Seok | Song, Charles | Kang, Ji Young | Lee, Hwa Young | Kim, In Kyoung | Kim, Sei Won | Rhee, Chin Kook | Kim, Seung Joon | Kim, Seok Chan | Lee, Sook Young | Kim, Young Kyoon | Kwon, Soon Seog | Choi, Joon Young | Park, Pona | Jin, Hong Ryul | Kim, Dong-Kyu | Kim, Dae Woo | Hogenkamp, Astrid | Knippels, Leon | Van Esch, Betty C.a.m. | Van Bilsen, Jolanda | Jeurink, Prescilla V. | Gros, Marjan | Garssen, Johan | Smit, Joost J. | Pieters, Raymond H. H. | Kim, Boo-Young | Kim, Soo Whan | Lleonart, Ramon | Lay, Christophe | Benamor, Kaouther | Chen, Chua Mei | Knol, Jan | Chew, Charmaine | Chongsrisawat, Voranush | Goh, Anne | Chiang, Wen Chin | Rao, Rajeshwar | Chaithongwongwatthana, Surasith | Khemapech, Nipon | Yhi, Ji Young | Kim, Sang-Heon | Park, Dong Won | Moon, Ji-Yong | Kim, Tae Hyung | Sohn, Jang Won | Shin, Dong Ho | Yoon, Ho Joo | Cho, Seok Hyun | Kim, Sang-Heon | Moon, Ji-Yong | Lee, Jae-Hyun | Ban, Ga Young | Kim, Sujeong | Kim, Mi-Ae | Kim, Joo-Hee | Kim, Min-Hye | Park, Chan-Sun | Kwon, Hyouk-Soo | Kwon, Jae-Woo | Jung, Jae Woo | Kang, Hye-Ryun | Park, Jong-Sook | Kim, Tae-Bum | Park, Heung Woo | Cho, You Sook | Yoo, Kwang-Ha | Oh, Yeon-Mok | Lee, Sang-Rok | Julge, Kaja | Vasar, Maire | Vasar, Maire | Voor, Tiia | Rebane, Tiina | Kim, Yu Jin | Lee, Sang Min | Kang, Shin Myung | Kim, Sojeong | Kyung, Sun Young | Jeong, Sung Hwan | Park, Jeong-Woong | Hwang, Hyunjung | Seon, Yong Han | Park, Sanghui | Lee, Sang Pyo | Iordache, Marius | Jeong, Yeongsang | Eun, Sohee | Choi, Byung Min | Choung, Ji Tae | Seo, Wonhee | Zhang, Liang | Pawankar, Ruby | Nonaka, Manabu | Hayashi, Miyuki | Yamanishi, Shingo | Suzaki, Harumi | Itoh, Yasuhiko | Watanabe, So | Kobayashi, Hitome | Zotter, Zsuzsanna | Farkas, Henriette | Varga, Lilian | Veszeli, Nora | Imreh, Eva | Kovacs, Gabor | Nallbani, Marsel | Zheleznov, Semen | Urzhumtseva, Galina | Petrova, Natalia | Sarsaniia, Zhanna | Didkovskii, Nikolai | Zuberbier, Torsten | Gerdabi, Nader Dashti | Khodadadi, Ali | Abdoli, Zahra | Ghafourian, Mehri | Assarehzadegan, Mohammad Ali | Ghorban, Khodayar | Kim, Hyo-Bin | Zhou, Hui | Kim, Jeong Hee | Habre, Rima | Bastain, Theresa | Gilliland, Frank | Bae, Jong-Wook | Han, Kyu-Hyung | Jee, Young-Koo | Choi, Misoo | Hong, Seung-Phil | Kim, Seung-Hyun | Kim, Hee-Kyoo | Choi, Gil-Soon | Heo, Jeonghoon | Kim, Young-Ho | Park, Eun-Kee | Inoue, Takashi | Ogura, Kiyotake | Yanagida, Noriyuki | Unno, Hirotoshi | Nagakura, Kenichi | Manabe, Tetsuharu | Asaumi, Tomoyuki | Sato, Sakura | Okada, Yu | Ebisawa, Motohiro | Kim, Min-Gu | Cho, You Sook | Kim, Tae-Bum | Moon, Hee-Bom | Kim, Jung-Hyun | Kim, Hyo-Jung | Park, So-Young | Seo, Bomi | Kwon, Hyouk-Soo | Lee, Jaemoon | Lee, Taehoon | Yoo, Hye-Soo | Kim, Jieun | Kim, Inok | Kim, Haejin | Chang, Younhee | Park, Hae-Sim | Lee, Sooyoung | Lee, Sooyoung | Kuzume, Kazuyo | Koizumi, Munemitsu | Nishimura, Koji | Okamoto, Michiko | Kim, Seung-Hyun | Ye, Young Min | Hur, Gyu Young | Park, Hae-Sim | Kim, Sang-Heon | Jee, Young-Koo | Kim, Seung-Hyun | Choi, Hyunna | Ye, Young Min | Park, Hae-Sim | Van Khanh, Bui | Chu, Hieu Chi | Nguyet, Nguyen Nhu | Phuong, Nguyen Hoang | Roh, Joo Young | Kim, Hyun Jeong | Kim, Jung Eun | Lew, Bark-Lynn | Lee, Kyung Ho | Hong, Seung-Phil | Jang, Yong Hyun | Park, Kui Young | Seo, Seong Jun | Bae, Jung Min | Choi, Eung Ho | Suhr, Ki Beom | Lee, Seung Chul | Ko, Hyun-Chang | Park, Young Lip | Son, Sang Wook | Seo, Young Jun | Lee, Yang Won | Cho, Sang Hyun | Park, Chun Wook | Lee, Kun Hee | Kim, Sung Wan | Chu, Chia-Yu | Aw, Derrick | Ye, Young-Min | Bader, Giovanni | Dolfi, Fabrizio | Oliveira, Nathalie | Choi, Jae Chol | Jung, Jae Woo | Kang, Hye-Ryun | Kim, Kijeong | Choi, Byoung Whui | Shin, Jong Wook | Jung, Jae Woo | Choi, Jae Chol | Park, In Won | Choi, Byoung Whui | Kim, Jae Yeol | Lee, Jin-Young | Ha, Kyoung Won | Jeung, Yun-Jin | Yune, Sehyo | Lee, Byung-Jae | Choi, Dong-Chull | Oh, Mi-Jung | Lim, Young Hee | Lee, Eui Jun | Suh, Dongin | Suh, Dongin | Woo, Sung-Il | Woo, Sung-Il | Cho, Hwa Jin | Cho, Hwa Jin | Chung, Eun Hee | Chung, Eun Hee | Chung, Soo Youn | Shah, Ashok | Gera, Kamal | Ha, Kyoung Won | Oh, Mi-Jung | Lim, Young Hee | Yune, Sehyo | Paeng, Jae-Won | Jang, Mi-Jin | Lee, Byung-Jae | Choi, Dong-Chull | Lee, Jin-Young | Jang, Mi-Jin | Paeng, Jae-Won | Jeung, Yun-Jin | Lim, Young Hee | Oh, Mi-Jung | Ha, Kyoung Won | Lee, Byung-Jae | Choi, Dong-Chull | Yune, Sehyo | Lee, Jin-Young | Ito, Takahiro | Lee, Jin-Young | Yune, Sehyo | Lee, Byung-Jae | Choi, Dong-Chull | Jang, Mi-Jin | Paeng, Jae-Won | Kim, Young Eun | Kim, Young Nam | Lee, Yongseok | Kim, Jihye | Lee, Hwa Young | Lee, Sook Young | Kwon, Soon Seog | Kim, Young Kyoon | Rhee, Chin Kook | Kim, Sei Won | Lee, Hea Yon | Choi, Joon Young | Kim, In Kyoung | Aranzabal, Maria Ascension | Joral, Alejandro | Lizarza, Susana | Echenagusia, Miguel | Lasa, Eva Maria | Navarro, Jose Antonio | Jo, Eun-Jung | Jang, Sun-Mi | Song, Seung-Eon | Na, Hae-Jung | Kim, Chang-Hoon | Lee, Woo-Seop | Park, Hye-Kyung | Miyauchi, Sachiko | Uchida, Yoshitaka | Soma, Tomoyuki | Yamazaki, Susumu | Noguchi, Toru | Kobayashi, Takehito | Nakagome, Kazuyuki | Nagata, Makoto | Oh, Hea Lin | Kim, Do Kyun | Suh, Dongin | Koh, Young Yull | Lee, Jin-Young | Lee, Byung-Jae | Choi, Dong-Chull | Paeng, Jae-Won | Jang, Mi-Jin | Kim, Jihye | Kim, Young Nam | Yune, Sehyo | Kim, Sang-Hoon | Sohn, Jang Won | Yoon, Ho Joo | Shin, Dong Ho | Lee, Jae Hyung | Lee, Byoung Hoon | Kim, Youn-Seup | Park, Jae-Seuk | Jee, Young-Koo | Kim, Sang-Heon | Lee, Jin-Young | Paeng, Jae-Won | Jang, Mi-Jin | Choi, Dong-Chull | Lee, Byung-Jae | Lee, Yongseok | Kim, Young Eun | Yune, Sehyo | Yoon, Jisun | Zhang, Li | Cai, Xuxu | Feng, Yong | Yoon, Jong-Seo | Jeong, Kyunguk | Yoo, Hye-Soo | Lee, Sooyoung | Lee, Sooyoung | Lee, Hae-Jin | Lee, Noo Ri | Kim, Bo-Kyung | Jung, Minyoung | Kim, Dong Hye | Moniaga, Catharina S. | Kabashima, Kenji | Choi, Eung Ho | Yanagida, Noriyuki | Sato, Sakura | Sugizaki, Chizuko | Ebisawa, Motohiro | Kiehm, Jamie | Ponda, Punita | Farzan, Sherry | Weiss, Jared | Elera, Claudia | Destio, Catherine | Sison, Cristina | Lee, Annette | Ri, Soo Hyun | Lim, Chang Hoon | Pulido, Iñaki Izquierdo | Taubel, Jorg | Ferber, Georg | Masdeu, Eva Santamaria | Khayatzadeh, Alireza | Movahedi, Masoud | Ebisawa, Motohiro | Gharagozlou, Mohammad | Atasoy, Ulus | Techasintana, Patsharaporn | Gubin, Matt | Glascock, Jacqueline | Ridenhour, Suzanne | Magee, Joseph | Filho, Nelson Rosario | Neto, Herberto Jose Chong | Wandalsen, Gustavo Falbo | Dela Bianca, Ana Caroline | Aranda, Carolina | Sole, Dirceu | Mallol, Javier | Garcia-Marcos, Luis | Garcia-Marcos, Luis | Toh, Jennifer | Lee, Yoomie | Huang, Joyce | Jerschow, Elina | Shliozberg, Jenny | Satitsuksanoa, Pattraporn | Suratannon, Narissara | Wongpiyabovorn, Jongkonnee | Chatchatee, Pantipa | Ruxrungtham, Kiat | Jacquet, Alain | Yang, Min Suk | Lee, Jin Yong | Kim, Ja Yeun | Park, Han-Ki | Kim, Ju-Young | Song, Woo-Jung | Kang, Hye-Ryun | Park, Heung Woo | Chang, Yoon-Seok | Cho, Sang-Heon | Min, Kyung-up | Park, Chang-Han | Chang, Suk-Il | Song, Sook-Hee | Kim, Si-Heon | Choi, Gil-Soon | Kim, Su-Chin | Kim, Ji Hye | Ban, Ga Young | Shin, Yoo Seob | Park, Hae-Sim | Ye, Young Min | Hwang, Yoon Ha | Sim, Da Woon | Park, Kyung Hee | Park, Kyung Hee | Park, Hye Jung | Park, Hye Jung | Park, Jung-Won | Park, Jung-Won | Lee, Jae-Hyun | Lee, Jae-Hyun | Allen, Katrina | Beck, Cara | Koplin, Jennifer | Matheson, Melanie | Tang, Mimi | Ponsonby, Anne-Louise | Gurrin, Lyle | Dharmage, Shyamali | Wake, Melissa | Mcwilliam, Vicki | Liu, Xiaoying | Wang, Jing | Xiang, Li | Wang, Qun | Lee, Ji-Eun | Kim, Dong-Young | Rhee, Chae-Seo | Rhee, Chae-Seo | Vazquez-Nava, Francisco | Cho, Sang-Heon | Jeong, Jaewon | Perng, Diahn-Warng | Price, David | Neira, Glenn | Lin, Jiangtao | Semernik, Olga | Kim, Ha-Su | Jung, Jin-a | Jung, Ji-in | Miao, Qing | Xiang, Li | Cho, Sang-Heon | Jeong, Jaewon | Perng, Diahn-Warng | Lin, Jiangtao | Price, David | Neira, Glenn | Lee, Hyun Young | Park, Hae-Sim | Ye, Young Min | Kim, Su Chin | Farrokhi, Shokrollah | Gheiby, Mohammadkazem | Kim, Sang-Heon | Park, Heung Woo | Kim, Sang-Hoon | Jee, Young-Koo | Park, Sunjoo | Moon, Keun Ai | Kwon, Hyouk-Soo | Kim, Tae-Bum | Cho, You Sook | Moon, Hee-Bom | Lee, Kyoung Young | Hong, Gyong Hwa | Ha, Eun Hee | Han, Heejae | Park, Hye Jung | Park, Yoon Hee | Kim, Yoon-Jo | Lee, Kangtaek | Park, Jung-Won | Lee, Jae-Hyun | Slavyanskaya, Tatiana | Derkach, Vladislava | Park, Hye Jung | Hong, Chein-Soo | Lee, Jae-Hyun | Kim, Sungryeol | Park, Kyung Hee | Lee, Choong-Kun | Kang, Beodeul | Beom, Seung-Hoon | Shin, Sang Joon | Jung, Minku | Park, Jung-Won | Kim, Eun-Hee | Kim, Ji-Hye | Mo, Ji-Hun | Chung, Young-Jun | Kim, Mi-Ae | Park, Hae-Sim | Yoon, Moon Gyeong | Lee, Young-Soo | Kim, Ji Hye | Ban, Ga Young | Yoo, Hye-Soo | Shin, Yoo Seob | Ye, Young Min | Nahm, Dong-Ho | Miao, Qing | Xiang, Li | Li, Ying-Ji | Shimizu, Takako | Inagaki, Hirofumi | Hirata, Yukiyo | Takizawa, Hajime | Azuma, Arata | Yamamoto, Masayuki | Kawada, Tomoyuki | Kim, Min-Gu | Hong, Gyong Hwa | Lee, Kyoung Young | Ha, Eun Hee | Moon, Keun Ai | Park, Sunjoo | Kwon, Hyouk-Soo | Kim, Tae-Bum | Moon, Hee-Bom | Cho, You Sook | Kim, Jung-Hyun | Kim, Hyo-Jung | Park, So-Young | Seo, Bomi | Kim, Ji-Hye | Samivel, Ramachandran | Kim, Eun-Hee | Chung, Young-Jun | Mo, Ji-Hun | Soumya, M. S. | Inbaraj, G. | Chellaa, R. | Pawankar, Ruby | Choi, Wonsun | Park, Hae-Sim | Ye, Young Min | Kim, Ji Hye | Ban, Ga Young | Shin, Yoo-Seob | Braber, Saskia | Verheijden, Kim | Kraneveld, Aletta | Garssen, Johan | Folkerts, Gert | Willemsen, Linette | Eichhorn, Stephanie | Ferreira, Fatima | Pablos, Isabel | Kastner, Bianca | Schweidler, Bettina | Wildner, Sabrina | Briza, Peter | Park, Jung-Won | Arora, Naveen | Vieths, Stefan | Gadermaier, Gabriele | Park, Sung-Min | Lee, Won-Ku | Kim, Jeong-Min | Kim, Gun-Wook | Mun, Je-Ho | Kim, Hoon-Soo | Song, Margaret | Ko, Hyun-Chang | Kim, Moon-Bum | Kim, Byung Soo | Kim, Young Nam | Yune, Sehyo | Lee, Jin-Young | Kim, Jihye | Kim, Young Eun | Paeng, Jae-Won | Jang, Mi-Jin | Choi, Dong-Chull | Lee, Byung-Jae | Lee, Yongseok | Goh, Si Hui | Lee, Bee Wah | Soh, Jian Yi | Kang, Hyungoo | Kim, Hyunhee | Yum, Hye-Yung | Ye, Young Min | Park, Hae-Sim | Ban, Ga-Young | Kim, Ji Hye | Shin, Yoo Seob | Takizawa, Takumi | Tabata, Masahiko | Aizawa, Akira | Yagi, Hisako | Nishida, Yutaka | Arakawa, Hirokazu | Morikawa, Akihiro | Orosoo, Solongo | Braber, Saskia | Bol-Schoenmakers, Marianne | Akbari, Peyman | Jeurink, Prescilla V. | Jeurink, Prescilla V. | De Graaff, Priscilla | Smit, Joost J. | Van Esch, Betty C. A. M. | Garssen, Johan | Garssen, Johan | Fink-Gremmels, Johanna | Pieters, Raymond H. H. | Kim, Gun-Woo | Jo, Eun-Jung | Kim, Sujeong | Song, Woo-Jung | Chang, Yoon-Seok | Faruqi, Shoaib | Kim, Ju-Young | Kang, Mingyu | Kim, Min-Hye | Plevkova, Jana | Park, Heung Woo | Cho, Sang-Heon | Morice, Alyn | Lee, So-Hee | Kim, Sun-Sin | Lee, Seoung-Eun | Gemicioglu, Bilun | Misirligil, Zeynep | Cimrin, Arif Hikmet | Gunen, Hakan | Ozlu, Tevfik | Cilli, Aykut | Akyildiz, Levent | Bayram, Hasan | Uzaslan, Esra | Abadoglu, Oznur | Suerdem, Mecit | Kainuma, Keigo | Kim, Hyun-a | Kim, Ha-Su | Bae, Woo Yong | Jung, Jin-a | Kamenwa, Rose | Macharia, William | Said, Nusrat | Nerurkar, Vidya | Patel, Meenal | Bhatia, Simi | Choi, Inseon S. | Kim, Soo-Jeong | Won, Joo-Min | Park, Myeong-Soo | Nagao, Mizuho | Park, Dong Won | Sohn, Jang Won | Yhi, Ji Young | Moon, Ji-Yong | Kim, Sang-Heon | Kim, Tae Hyung | Shin, Dong Ho | Yoon, Ho Joo | Hyo, Yukiyoshi | Lee, Jaechun | Kim, Su Hee | Lee, Eunkyoung | Jung, Hahn Jin | Lim, Jaehyun | Hong, Seung-No | Han, Doo Hee | Rhee, Chae-Seo | Lee, Kun Song | Lee, Jaechun | Yang, Sun Young | Ahn, Mi Young | Lee, Jong Hoo | Golez, Jasmina | Tian, Hui-Qin | Cheng, Lei | Chen, Xin-Yuan | Moon, Ji-Yong | Kim, Sang-Heon | Kim, Tae Hyung | Yhi, Ji Young | Yoon, Ho Joo | Sohn, Jang Won | Shin, Dong Ho | Park, Dong Won | Cho, Won Im | Choi, Jong Sub | Suh, Dongin | Kang, Gyeong Hoon | Moon, Jin Soo | Ko, Jae Sung | Lee, Kyung Jae | Choi, Shin Jie | Luo, Wenting | Sun, Baoqing | Gao, Qi | Xiang, Li | Shen, Kunling | Jang, Yong Hyun | Bergmann, Karl-Christian | Sehlinger, Torsten | Bölke, Georg | Berger, Uwe | Zuberbier, Torsten | Kolodziejczyk, Joanna | Wojciechowska, Milena | Hnatyszyn-Dzikowska, Anna | Chojnacki, Micha | Bartuzi, Zbigniew | Masaki, Katsunori | Fukunaga, Koichi | Kamatani, Takashi | Ohtsuka, Kengo | Tanosaki, Takae | Matsusaka, Masako | Mochimaru, Takao | Kabata, Hiroki | Ueda, Soichiro | Suzuki, Yusuke | Kamei, Katsuhiko | Asano, Koichiro | Betsuyaku, Tomoko | Trafford, Karlee | Bulut, Ismet | Ozseker, Zeynep Ferhan | Horimukai, Kenta | Morita, Hideaki | Narita, Masami | Niizeki, Hironori | Matsumoto, Kenji | Ohya, Yukihiro | Saito, Hirohisa | Kabashima, Shigenori | Kondo, Mai | Inoue, Eisuke | Siebers, Robert | Wu, Francis F. S. | Siebers, Robert | Wu, Francis F. S. | Ting, Ming-Hui | Laio, Hung-En | Kuo, Tsung-Huai | Lee, Pei-Yuan | Maddox, Daniel Eugene | Ryu, Gwanghui | Kim, Hyo Yeol | Dhong, Hun-Jong | Hong, Sang Duk | Chung, Seung-Kyu | Higuchi, Osamu | Adachi, Yu-Ichi | Itazawa, Toshiko | Adachi, Yoko | Hamamichi, Miki | Nakabayashi, Motokazu | Ito, Yasunori | Wada, Takuya | Murakami, Gyoukei | Takao, Miki | Yamamoto, Junko | Jin, Hyun Jung | Yoon, Moon Gyeong | Ye, Young Min | Shin, Yoo-Seob | Kim, Seung-Hyun | Park, Hae-Sim | Min, Taek-Ki | Pyun, Bok-Yang | Lee, So-Yeon | Kim, Hyun Hee | Jang, Gwang-Cheon | Yu, Jinho | Suh, Dongin | Lee, Sooyoung | Park, Yong Mean | Kim, Jeong Hee | Yum, Hye-Yung | Kim, Kyung Won | Yang, Hyeon-Jong | Ahn, Kangmo | Kwon, Ji-Won | Sohn, Myung Hyun | Lee, Hae Ran | Kwon, Jung Hyun | Kim, Kyu-Earn | Hong, Soo-Jong | Cho, Su-Mi | Nahm, Dong-Ho | Kim, Myoung-Eun | Lee, Jin Hwa | Rhee, Chin Kook | Park, Hye Yun | Kim, Woo Jin | Park, Yong Bum | Yoo, Kwang-Ha | Kang, Heejeong | Yang, Hyeon-Jong | Min, Taek-Ki | Pyun, Bok-Yang | Suk, Lee Ju | Kim, Cheol Hong | Kwon, Jung Hyun | Lee, Sang Hyun | Seo, Wonhee | Kim, Kang-in | Park, Young Cheon | Yang, Hyeon-Jong | Min, Taek-Ki | Pyun, Bok-Yang | Kim, Sujeong | Jin, Sun | Lee, Jong-Myung | Jung, Hye-Jin | Park, Jung-Wha | Kim, Hyo-Jung | Kim, Tae-Bum | Cho, You Sook | Moon, Hee-Bom | Kwon, Hyouk-Soo | Park, So Young | Park, So-Young | Kim, Jung-Hyun | Seo, Bomi | Kim, Min-Gu | Kim, Youn Yee | Lee, Yena | Min, Taek-Ki | Yang, Hyeon-Jong | Pyun, Bok-Yang | Han, Suk Hee | Park, Suyeon | Lee, Jeongho | Hahn, Won-Ho | Jeon, Youhoon | Kim, Joo-Hee | Shin, Tae-Rim | Kim, Cheol-Hong | Hyun, In-Gyu | Choi, Jeong-Hee | Jang, Sun-Mi | Na, Hae-Jung | Song, Seung-Eon | Park, Hye-Kyung | Jo, Eun-Jung | Lee, Dong Hun | Lee, Jin-Young | Park, Yang | Oh, Jae-Won | Lee, Mi Hee | Hong, Soo-Jong | Hong, Soo-Jong | Lee, So-Yeon | Park, Joon Soo | Nahm, Dong-Ho | Yum, Hye-Yung | Yum, Hye-Yung | Choi, Kyu Young | Kim, Dong-Young | Palapinyo, Sirinoot | Klaewsongkram, Jettanong | Chen, Xing | Jin, Yuting | Hou, Xiaoming | Liu, Fengqin | Guo, Chunyan | Wang, Yulin | Okafuji, Ikuo | Tanaka, Yuya | Narabayashi, Shegeyuki | Tsuruta, Satoru | Jang, Yong Hyun | Ahn, Jun-Hong | Lee, Dong-Won | Chung, Jin Hong | Jin, Hyun Jung | Sohn, Min-Su | Park, Young a | Jeong, Kyunguk | Kim, Yoon Hee | Sol, In Suk | Yoon, Seo Hee | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Lee, Sooyoung | Kim, Ho | Kim, Ja Yeun | Lee, So-Yeon | Min, Taek-Ki | Song, Tae-Won | Ahn, Kangmo | Kim, Jihyun | Jang, Gwang-Cheon | Yang, Hyeon-Jong | Pyun, Bok-Yang | Kwon, Ji-Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Yu, Jinho | Hong, Soo-Jong | Kwon, Jung-Hyun | Kim, Sung-Won | Lee, Sooyoung | Kim, Woo Kyung | Kim, Hyung Young | Kim, Hye-Young | Jeon, Youhoon | Lim, Chang Hoon | Jeong, Yeongsang | Kim, Su Jung | Chang, Hun Soo | Heo, Jeong-Seok | Bae, Da-Jeong | Lee, Jong-Uk | Kim, Ji-Na | Min, Chang-Gi | Song, Hyun Ji | Park, Jong-Sook | Kim, Soo Hyun | Park, Choon-Sik | Liu, Jing-Nan | Choi, Youngwoo | Shin, Yoo Seob | Park, Hae-Sim | Rezaei, Nima | Mahneh, Sedigheh Bahrami | Rezaei, Arezou | Sadr, Maryam | Movahedi, Masoud | Gang, Jun Seak | Park, Joon Soo | Kim, Seung Soo | Bang, Hyun Ho | Park, Kyeong Bae | Kim, Hye Sun | Kim, Tae Ho | Hwangbo, Young | Lee, Hyun Jung | Yoo, Gyeong Hee | Kim, Young Chang | Sato, Sakura | Yanagida, Noriyuki | Ebisawa, Motohiro | Palikhe, Sailesh | Park, Hae-Sim | Kim, Seung-Hyun | Kim, Ri-Yeon | Yang, Eun-Mi | Lee, Li Yuan Gabriella Nadine | Aw, Marion | Aw, Marion | Lee, Bee Wah | Lee, Bee Wah | Loo, Evelyn Xiu Ling | Chan, Yiong Huak | Shek, Lynette | Shek, Lynette | Kuo, I-Chun | Kuo, I-Chun | Quah, Phaik Ling | Quah, Phaik Ling | Llanora, Genevieve | Irvin, Gerez | Jung, Joo Hyun | Kang, Il Gyu | Kim, Seon Tae | Park, Hyoungmin | Kim, Seon Tae | Jung, Joo Hyun | Kang, Il Gyu | Park, Hyoungmin | Ko, Kwang-Pil | Lee, Jungsoo | Chu, Howard | Lee, Hemin | Shin, Jung U. | Park, Chang Ook | Lee, Kwang Hoon | Lee, Kwang Hoon | Kang, Hong Kyu | Lee, Dong Chang | Kim, Geun Jeon | Hwang, Jae Hyung | Ha, Jin Bu | Jeong, Su Hee | Kim, Ho | Hwang, Shinha | Lee, Whahee | Bazarsad, Enkhbayar | Narantsetseg, Logii | Sonomjamts, Munkhbayarlakh | Jang, Gwang-Cheon | Lee, Hyun-Hee | Lee, Chang-Jong | Lim, Huynsun | Soh, Ji-Eun | Song, Dae-Jin | Kwon, Ji-Won | Kim, Hyung Young | Seo, Ju-Hee | Kim, Byoung-Ju | Kim, Hyo-Bin | Lee, So-Yeon | Jang, Gwang-Cheon | Kim, Woo Kyung | Jung, Young-Ho | Hong, Soo-Jong | Shim, Jung Yeon | Bazarsad, Enkhbayar | Narantsetseg, Logii | Sonomjamts, Munkhbayarlakh | Pv, Prabhakarrao | Nadendla, Ranjitha | Fang, Juan | Zhao, Jing | Song, Dae-Jin | Seo, Sungchul | Yoo, Young | Kim, Yu-Ri | Choung, Ji Tae | Lee, Jee Hoo | Berings, Margot | De Ruyck, Natalie | Bachert, Claus | Gevaert, Philippe | Holtappels, Gabriële | Lee, Pureun-Haneul | Kim, Byeong-Gon | Park, Choon-Sik | Leikauf, George D. | Jang, An-Soo | Kimc, Byeong-Gon | Lee, Pureun-Haneul | Park, Choon-Sik | Jang, An-Soo | Park, Yang | Sohn, Min-Su | Jin, Hyun Jung | Lee, Dong-Won | Ahn, Jun-Hong | Chung, Jin Hong | Kim, Sae-in | Park, Han-Ki | Kim, Do-Yeon | Rho, Mina | Choi, Jun-Pyo | Kim, Yoon-Keun | Kamchaisatian, Wasu | Hiranras, Thitikul | Wongpun, Surinda | Chiraphorn, Phornthip | Tantachun, Anupan | Wongrassamee, Wannipa | Vatanasurkitt, Planee | Somboonkul, Naratip | Juthacharoenwong, Nattipat | Techapaitoon, Surangkana | Tuchinda, Montri | An, Sejin | Lee, Jae Ho | Shin, Ji-Hyeon | Kim, Soo Whan | Kim, Si Won | Kang, Jun Myung | Kim, Boo-Young | Kim, Byung-Guk | Kwon, Ji-Won | Kim, Woo Kyung | Kim, Hyung Young | Kim, Hyo-Bin | Seo, Ju-Hee | Lee, So-Yeon | Jang, Gwang-Cheon | Jung, Young-Ho | Hong, Soo-Jong | Kim, Byoung-Ju | Song, Dae-Jin | Shim, Jung Yeon | Lee, Jung-Won | Kim, Kyung Ho | Yoo, Young | Yoon, Won Suck | Seo, Sungchul | Kang, In Soon | Choi, Jae Won | Lim, Hye-Young | Choung, Ji Tae | Buela, Michelle | Nishimura, Koji | Park, Sang Chul | Chung, Hyo Jin | Kim, Chang-Hoon | Kang, Ju Wan | Hong, Seong-Chul | Lee, Keun-Hwa | Lee, Jaechun | Lee, Hye-Sook | Kim, Jeong Hong | Logii, Narantsetseg | Nyamdavaa, N. | Enkhbayar, B. | Oyuntsatsral, B. | Munkhbayarlakh, S. | Bazarsad, Enkhbayar | Sonomjamts, Munkhbayarlakh | Omarjee, Bashir | Li, Shuo | Hayashi, Miyuki | Pawankar, Ruby | Yamanishi, Shingo | Igarashi, Toru | Itoh, Yasuhiko | Gantulga, B. | Enkhbayar, B. | Munkhbayarlakh, S. | Narantsetseg, L. | Batsaikhan, Oyuntsatsral | Chen, Pei-Chi | Wang, Jiu-Yao | Leung, Nicki Y. H. | Wai, Christine Yee Yan | Leung, Patrick S. C. | Chu, Ka Hou | Doh, Eun Jin | Lee, Dong Hun | Choi, Mira | Yoon, Hyun-Sun | Kim, Kyu Han | Lim, Ji Soo | Baek, Ji Hyeon | Han, Man Yong | Lee, Seung Jin | Jeon, Youhoon | Lee, Kyung Suk | Jung, Young-Ho | Jee, Hye Mi | Shin, Youn Ho | Jiang, Yi | Liu, Miao | Naing, Chaw Su | Tan, Tze Chin | Chong, Yong Yeow | Kim, Young-Ho | Lee, Eun | Yang, Song-I | Cho, Hyun-Ju | Kim, Hyung Young | Kwon, Ji-Won | Jung, Young-Ho | Kim, Byoung-Ju | Seo, Ju-Hee | Kwon, Ho-Jang | Kim, Hyo-Bin | Lee, So-Yeon | Hong, Soo-Jong | Kim, Soo Hyun | Joseph, Jacqueline Elizabeth | Soumya, M. S. | Pawankar, Ruby | Kumar, Harshitha | Yang, Sohyoung | Woo, Sung-Il | Rezaei, Nima | Kose, Sukran | Serin, Basak Gol | Yalcin, Arzu Didem | Senger, Süheyla Serin | Erden, Mehmet | Serin, Ertan | Leung, Ting Fan | Leung, Agnes Sze-Yin | Kumar, Harshitha | Soumya, M. S. | Joseph, Jacqueline Elizabeth | Pawankar, Ruby | Chung, Eun Hee | Kim, Eunji | Yoo, Young | Yoo, Young | Choung, Ji Tae | Choung, Ji Tae | Seo, Sungchul | Seo, Sungchul | Kang, In Soon | Lee, Jue Seong | Hwang, Ji Hyen | Lee, Sang Min | Jung, Joo Hyun | Choi, Seung Joon | Joe, Eugene | Hwang, Hyunjung | Kang, Shin Myung | Kim, Yu Jin | Kyung, Sun Young | Park, Jeong-Woong | Jeong, Sung Hwan | Lee, Sang Pyo | Gaisina, Alina | Shilovskiy, Igor | Nikonova, Aleksandra | Kamyshnikov, Oleg | Khaitov, Musa | Mitin, Alexander | Viktoriya, Komogorova | Litvina, Marina | Sharova, Nina | Faiah, M. J. | Ismail, Intan H. | Miles, E. A. | Jamli, Faizah Mohamed | Choi, Jun-Pyo | Choi, Han-Byul | Kim, Yoon-Keun | Choi, Hyeon-Il | Yoon, Da-Il | Kang, Mingyu | Kim, Mi Yeoung | Kim, Sujeong | Jo, Eun-Jung | Lee, Seoung-Eun | Song, Woo-Jung | Lee, Sang Min | Park, Chansun | Chang, Yoon-Seok | Lee, Jaechun | Jee, Young-Koo | Choi, Inseon S. | Min, Kyung-up | Cho, Sang-Heon | Cho, Sang-Heon | Laskin, Anton | Kamyshnikov, Oleg | Babakhin, Alexander | Berzhets, Valentina | Khaitov, Musa | Lee, Jae Ho | An, Sejin | Chang, Yoon-Seok | Min, Kyung-up | Cho, Sang-Heon | Kim, Sae-Hoon | Kwon, Yong Eun | Jee, Young-Koo | Kim, Tae-Bum | Moon, Hee-Bom | Park, Hye-Kyung | Kang, Sung-Yoon | Choi, Jun-Pyo | Park, Han-Ki | Lee, Ji-Hyun | Kim, Yoon-Keun | Kim, Sang-Yoon | Hwang, Hyunjung | Joe, Eugene | Lee, Sang Min | Choi, Seung Joon | Jung, Joo Hyun | Seon, Yong Han | Kang, Shin Myung | Kim, Yu Jin | Kyung, Sun Young | Park, Jeong-Woong | Jeong, Sung Hwan | Lee, Sang Pyo | Khramykhoverchenko, Natalya | Sultana, Asma | Halwani, Rabih | Bahammam, Ahmed | Al Muhsen, Saleh | Kim, Sun Kyung | Nam, Kwang Il | Yang, Hyung Chae | Kim, Jeong-Eun | Lee, Ju Suk | Lee, Ji Hyun | Kang, Kyung Woo | Kim, Je-Kyung | Hahn, Youn-Soo | Jung, Jae-Yub | Baba, Yosuke | Yamazaki, Sususmu | Inage, Eisuke | Mori, Mari | Ohtsuka, Yoshikazu | Kantake, Masato | Shimizu, Toshiaki | Honjoh, Asuka | Yokokura, Tomoaki | Elhassan, Shaza Ali Mohammed | Beck, Caroline | Adeli, Mehdi | Baek, Heysung | Lee, Seung Jin | Baek, Ji Hyeon | Yoon, Jungwon | Choi, Sun Hee | Jung, Young-Ho | Shin, Youn Ho | Han, Man Yong | Na, Min Sun | Compalati, Enrico | Marogna, Maurizio | Huang, Huimin | Sun, Baoqing | Bai, Mingyu | Huo, Yiting | Zheng, Peiyan | Wei, Nili | Luo, Wenting | Andiappan, Anand | Minisini, Rosalba | Rötzschke, Olaf | Boggio, Elena | Gigliotti, Luca | Clemente, Nausicaa | Chiocchetti, Annalisa | Dianzani, Umberto | Pirisi, Mario | Villa, Elisa | Yamaide, Fumiya | Yonekura, Syuji | Shimojo, Naoki | Inoue, Yuzaburo | Okamoto, Yoshitaka | Setyoningrum, Retno Asih | Setiawati, Landia | Sumei, Sri | Iskandar, Deddy | Kompiyang, Indriyani Sang Ayu | Oguma, Tsuyoshi | Tanaka, Jun | Tomomatsu, Katsuyoshi | Asano, Koichiro | Uno, Keisuke | Matsuwaki, Yoshinori | Omura, Kazuhiro | Hayashi, Eika | Tatsumi, Norifumi | Kita, Hirohito | Otori, Nobuyoshi | Kojima, Hiromi | Khorasgani, Mohammadreza Fatemi | Lew, Dukhee/Betty | Lemessurier, Kim/S. | Moore, Joseph/a | Park, Jeoung-Eun | Yi, Ae-Kyung | Song, Chi/Young | Malik, Kafait/U | Kim, Ja Kyoung | Yang, Hyeon-Jong | Kim, Bong-Seong | Shin, Youn Ho | Lee, So-Yeon | Park, Geunhwa | Kim, Woo Kyung | Kim, Hyo-Bin | Baek, Heysung | Lim, Dae Hyun | Lim, Dae Hyun | Kim, Jin Tack | Suh, Dongin | Nano, Aimee Lou Manalo | Sun, Baoqing | Luo, Wenting | Nacaroglu, Hikmet Tekin | Erdem, Semiha Bahceci | Sumer, Ozlem | Karaman, Sait | Karkiner, Canan Sule Unsal | Asilsoy, Suna | Gunay, Ilker | Can, Demet | Kiers, Danielle | Wang, Jiu-Yao | Yin, Hsu Han | Kaplan, Allen | Joseph, Kusumam | Tholanikunnel, Baby G. | Dudek, Radim | Bilgin, Gulden | Surer, Hatice | Kilinc, Aytun Sadan | Yucel, Dogan | Lee, Ji Young | Kim, Jihyun | Yang, Hea-Kyoung | Kim, Minji | Lee, Sang-Il | Ahn, Kangmo | Moon, Sung Do | Kim, Byung-Keun | Cho, Sang-Heon | Min, Kyung-up | Chang, Yoon-Seok | Park, Heung Woo | Kang, Hye-Ryun | Song, Woo-Jung | Kang, Min-Koo | Kim, Ju-Young | Sohn, Kyonghee | Won, Ha Kyung | Lee, Seoung-Eun | Kim, Kyung-Mook | Bachert, Claus | Hsieh, Miao-Hsi | Wang, Jiu-Yao | Smith, Helen | Brown, Clare | Jones, Christina | Davies, Mark | Yoon, Won Suck | Lee, Hemin | Chu, Howard | Lee, Jungsoo | Shin, Jung U. | Park, Chang Ook | Lee, Kwang Hoon | Lee, Kwang Hoon | Kim, Seo Hyeong | Kim, Seo Hyeong | Noh, Ji Yeon | Kim, Ji Hye | Kim, Ji Hye | Yoon, Won Suck | L’huillier, Jean-Pierre | Autegarden, Jean-Eric | Bertrand, Catherine | Tardy, Dominique | Ismail, Intan Hakimah | Tang, Mimi | Licciardi, Paul | Oppedisano, Frances | Boyle, Robert | Robins-Browne, Roy | Yagi, Hisako | Koyama, Harumi | Nishida, Yutaka | Takizawa, Takumi | Arakawa, Hirokazu | Kang, Hong Kyu | Lee, Hemin | Lee, Jungsoo | Shin, Jung U. | Lee, Kwang Hoon | Lee, Kwang Hoon | Chu, Howard | Park, Chang Ook | Yoon, Na Young | Lee, Hyeyoung | Seo, Seong Jun | Choi, Eunhee | Wang, Hye-Young | Jung, Minyoung | Choi, Eung Ho | Kim, Dong Hye | Kim, Joo-Hee | Jang, Young-Sook | Choi, Jeong-Hee | Park, Sunghoon | Hwang, Young Il | Jang, Seung Hun | Jung, Ki-Suck | Kang, Mi-Jin | Suh, Dongin | Lee, Eun | Choi, Kil Yong | Jung, Young-Ho | Yang, Song-I | Kim, Bong-Soo | Kim, Ha-Jung | Koh, Juneyoung | Kim, Hyun-Jin | Ahn, Kangmo | Shin, Youn Ho | Cho, Hyun-Ju | Kim, Byoung-Ju | Kim, Young-Ho | Jung, Yean | Mamura, Mizuko | Yoon, Jeong-Hwan | Nakae, Susumu | Lee, Inkyu | Matsumoto, Isao | Sumida, Takayuki | Han, Jin Soo | Sudo, Katsuko | Ju, Ji Hyeon | Yap, Gaik Chin | Liu, Wen Tso | Oh, Seungdae | Hong, Pei Ying | Huang, Chiung Hui | Aw, Marion | Shek, Lynette | Lee, Bee Wah | Byun, Young Seok | Kim, Sung Wan | Koh, Tae Kyung | Jo, Joong-Saeng | Lee, Kun Hee | Kwon, Chul | Dong, Sung-Hwa | Kim, Myung Shin | Park, Chansun | Cho, Han Seok | Kim, Min-Ju | Kim, Min Ji | Park, Young Ok | Lee, Hye Yeong | Kim, Hee Seong | Lee, Eun | Cho, Hyun-Ju | Yu, Jinho | Hong, Soo-Jong | Hwang, Keum Hee | Kim, Jung-Hyun | Cho, You Sook | Kim, Sae-Hoon | Kwon, Hyouk-Soo | Yoo, Mira | Kim, Hyo-Jung | Park, So-Young | Shin, Bomi | Park, So Young | Seo, Bomi | Kim, Min-Gu | Moon, Hee-Bom | Park, Jin-Ah | Kim, Tae-Bum | Lee, Jaemoon | Jeong, Jin Hyeok | Kang, Tae Wook | Yoo, Han Seok | Cho, Yong Hee | Cho, Seok Hyun | Kim, Kyung Rae | Lee, Jue Seong | Kee, Sun-Ho | Kim, Sewon | Yoo, Young | Na, Heung Sik | Back, Seung Keun | Lee, Seung Jin | Seo, Bo Seon | Baek, Ji Hyeon | Lee, Kyung Suk | Jung, Young-Ho | Jee, Hye Mi | Shin, Youn Ho | Han, Man Yong | Kim, Mi-Ae | Nam, Young-Hee | Jeon, Dong Sub | Lee, Soo-Keol | Park, Jisun | Moon, Seung Hyun | Lin, Rong Jun | Guan, Ren Zheng | Park, Gyeong Yul | Yoon, Hyun-Sun | Choi, Woo-Hyeok | Baek, Heysung | Park, Jin-Sung | Kwon, Eunmi | Callaway, Zac | Kim, Chang-Keun | Fujisawa, Takao | Zhang, Qingling | Qiu, Rihuang | Li, Naijian | Yang, Zhaowei | Li, Jing | Chung, Kian Fan | Zhong, Nanshan | Hon, Kam Lun E. | Tsang, Yin Ching K. | Leung, Ting Fan | Jang, Yoon Young | Chung, Hai Lee | Lee, Seung Gook | Na, Ji Hyun | Lee, Jong Hoon | Nam, Young-Hee | Jeon, Dong Sub | Lee, Soo-Keol | Yamamoto, Mikita | Sato, Sakura | Yanagida, Noriyuki | Ogawa, Ayako | Ogura, Kanako | Takahashi, Kyohei | Nagakura, Kenichi | Emura, Shigehito | Asaumi, Tomoyuki | Iikura, Katsuhito | Ebisawa, Motohiro | Okada, Yu | Luo, Jiaying | Lan, Xiao | Sun, Baoqing | Chen, Zhao | Sun, Guiyuan | Li, Shimin | Hu, Jiaqing | Choi, Woo-Hyeok | Baek, Heysung | Nam, Young-Hee | Jeon, Dong Sub | Nam, Hee-Joo | Noh, Yeo Myeong | Kim, Sang Hee Kim | Park, Ye Suel | Lee, Soo-Keol | Choi, Yean Jung | Lee, Si Hyeon | Kim, Young-Ho | Kang, Mi-Jin | Cho, Hyun-Ju | Lee, Eun | Yang, Song-I | Shin, Youn Ho | Ahn, Kangmo | Kim, Kyung Won | Kim, Yoon Hee | Lee, So-Yeon | Chang, Hyoung Yoon | Choi, In Ae | Lee, Kyung-Sook | Shin, Yee-Jin | Kim, Yoon Hee | Kim, Min Jung | Sol, In Suk | Yoon, Seo Hee | a Park, Young | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Lee, Yong Ju | Sol, In Suk | Kim, Kyu-Earn | Kim, Yoon Hee | Kim, Min Jung | Yoon, Seo Hee | Lee, Yong Ju | Kim, Kyung Won | a Park, Young | Sohn, Myung Hyun | Park, Sung Joo | Kwon, Ji-Won | Kim, Woo Kyung | Kim, Hyung Young | Kim, Hyo-Bin | Seo, Ju-Hee | Lee, So-Yeon | Jang, Gwang-Cheon | Jung, Young-Ho | Hong, Soo-Jong | Kim, Byoung-Ju | Song, Dae-Jin | Yang, Yun Seok | Shim, Jung Yeon | Jang, Yoon Young | Chung, Hai Lee | Kim, Ji Hye | Lee, Hyun Seok | Lee, Chang Ho | Cho, Changbum | Lim, Yun-Kyu | Kim, Kyu Rang | Kim, Mijin | Kim, Baek-Jo | Kim, Young-Min | Han, Youngshin | Kim, Jihyun | Cheong, Hae-Kwan | Jeon, Byoung-Hak | Ahn, Kangmo | Ming, Chuang/Yao | Wang, Jiu-Yao | Ling, Ye/Yi | Huang, Huimin | Sun, Baoqing | Chen, Yun | Zheng, Peiyan | Wei, Nili | Luo, Wenting | Lee, Do Hyeong | Choi, Gil-Soon | Kim, Hee-Kyoo | Park, Han Su | Park, So-Young | Kim, Hyo-Jung | Seo, Bomi | Kim, Jung-Hyun | Kim, Min-Gu | Kwon, Hyouk-Soo | Cho, You Sook | Moon, Hee-Bom | Kim, Tae-Bum | Lee, Yoon Su | Shin, Eun-Soon | Tanaka, Akio | Morioke, Satoshi | Ohya, Yukihiro | Shimojo, Naoki | Akasawa, Akira | Hide, Michihiro | Shizukawa, Hiroko | Watanabe, Naoto | Shin, Meeyong | Jang, Myeong Sun | Nam, Young-Hee | Noh, Yeo Myeong | Jeon, Dong Sub | Nam, Hee-Joo | Kim, Sang Hee Kim | Park, Ye Suel | Lee, Soo-Keol | Jung, Ji-in | Kim, Ha-Su | Kim, Hyun-a | Jung, Jin-a | Goh, Anne | Rao, Rajeshwar | Nandanan, Bindu | Van Elburg, Ruurd | Chien, Chua Mei | Jo, Juandy | Garssen, Johan | Garssen, Johan | Knippels, Leon | Sandalova, Elena | Chiang, Wen Chin | Nam, Young-Hee | Juong, Ji Young | Kim, Soo Jin | Kim, Eun Young | Lee, Su Mi | Son, Young Ki | Nam, Hee-Joo | Kim, Ki-Ho | Lee, Soo-Keol | Park, Da-Eun | Kang, Hye-Ryun | Park, Heung Woo | Lee, Hyun Seung | Chang, Yoon-Seok | Park, Jung-Won | Cho, Sang-Heon | Min, Kyung-up | Song, Woo-Jung | Lim, Hyunwook | Seo, Sungchul | Choung, Ji Tae | Yoo, Young | Park, Jun-Sik | Kim, Byung Kwan | Won, Ha Kyeong | Kang, Hye-Ryun | Kim, Byung-Keun | Moon, Sung Do | Kim, Ju-Young | Lee, So-Hee | Song, Woo-Jung | Park, Heung Woo | Kang, Min-Koo | Kim, Sun-Sin | Cho, Sang-Heon | Min, Kyung-up | Chang, Yoon-Seok | Sohn, Kyoung Hee | Kim, Kyung-Mook | Kim, Ki-Woong | Jang, Hak Chul | Nam, Young-Hee | Jeon, Dong Sub | Nam, Hee-Joo | Noh, Yeo Myeong | Kim, Sang Hee Kim | Park, Ye Suel | Lee, Soo-Keol | Leung, Ting Fan | Tang, Man Fung | Sy, Hing Yee | Chan, Wa Cheong | Tam, Wilson Wai San | Chung, Seung Kyu | Kim, Sujin | Hong, Sang Duk | Kim, Hyo Yeol Kim Hyo Yeol | Dhong, Hun-Jong | Jeong, Jong in | Nam, Young-Hee | Jeon, Dong Sub | Lee, Soo-Keol | Lee, Ji Won | Kang, Mingyu | Kim, Soon-Hee | Bae, Boram | Kim, Sujeong | Kang, Hye-Ryun | Chang, Yoon-Seok | Song, Woo-Jung | Park, Da-Eun | Lee, Hyun Seung | Park, Heung Woo | Park, Han-Ki | Park, Jung-Won | Nam, Young-Hee | Jeon, Dong Sub | Nam, Hee-Joo | Noh, Yeo Myeong | Kim, Sang Hee Kim | Park, Ye Suel | Lee, Soo-Keol | Hou, Yung-I | Wang, Jiu-Yao | Kim, Ja Hyeong | Hee, Seol Jae | Ha, Eun-Hee | Park, Hyesook | Ha, Mina | Hong, Yun-Chul | Kim, Yangho | Chang, Namsoo | Soma, Yuta | Watanabe, So | Pawankar, Ruby | Suzaki, Harumi | Kobayashi, Hitome | Nam, Young-Hee | Park, Chansun | Lee, Soo-Keol | Lee, Jongrok | Roh, Jooyoung | Ryu, Haryeong | Kim, Cheol-Woo | Cho, Jae Hwa | Eom, Mi Ra | Kang, Ji Young | Lee, Hye Gyeung | Choi, Hae Young | Lee, Hye Jin | Woo, Ju Yun | Byun, Ji Yeon | Choi, You Won | Kim, Ja Hyeong | Ha, Eun-Hee | Park, Hyesook | Ha, Mina | Hong, Yun-Chul | Kim, Yangho | Chang, Namsoo | Kwon, Jae-Woo | Chang, Hun Soo | Heo, Jeong-Seok | Lee, Jong-Uk | Park, Jong-Sook | Kim, Eusom | Kim, Soo Hyun | Park, Choon-Sik | Choi, Hae Young | Byun, Ji Yeon | Woo, Ju Yun | Choi, You Won | Jin, Hyun-Ju | Son, Jin-Hwa | Kim, Jeong-Min | Kim, Gun-Wook | Mun, Je-Ho | Song, Margaret | Ko, Hyun-Chang | Kim, Moon-Bum | Kim, Hoon-Soo | Kim, Byung Soo | Van Nunen, Sheryl | Van Nguyen, Dinh | Elias, Anthony | Lauer, Susannah Olivia | Lee, Seung-Chul | Lee, Ho-June | Bae, Jung Min | Ono, Emi | Dong, Sung-Hwa | Koh, Tae Kyung | Byun, Young Seok | Kim, Sung Wan | Jo, Joong-Saeng | Kwon, Chul | Lee, Kun Hee | Liu, Li-Fan | Lee, Sunghee | Chen, Wei-Leng | Wang, Jiu-Yao | Bae, Youin | Park, Gyeong-Hun | Kim, Suk Yeon | Lee, Hyun Seung | Song, Woo-Jung | Kang, Mingyu | Park, Han-Ki | Park, Da-Eun | Kang, Hye-Ryun | Park, Heung Woo | Chang, Yoon-Seok | Kim, Hye-Young | Min, Kyung-up | Cho, Sang-Heon | Lee, Ji-Won | Bae, Boram | Park, Jung-Won | Suzuki, Yasuhiro | Bulut, Ismet | Ozseker, Zeynep Ferhan | Ismail, Intan Hakimah | Boyle, Robert | Licciardi, Paul | Oppedisano, Frances | Robins-Browne, Roy | Tang, Mimi | Lee, Ji Won | Lee, Hyun Seung | Kang, Mingyu | Park, Da-Eun | Park, Han-Ki | Kim, Soon-Hee | Song, Woo-Jung | Kang, Hye-Ryun | Park, Heung Woo | Chang, Yoon-Seok | Park, Chang-Han | Chang, Suk-Il | Song, Sook-Hee | Min, Kyung-up | Cho, Sang-Heon | Bae, Boram | Shieh, Grace | Kim, Min Jung | Hong, Jung Yeon | Yoon, Seo Hee | Shim, Doo Hee | Sol, In Suk | Kim, Yoon Hee | Kim, Mi Na | Lee, Kyung Eun | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Lee, Jae Myun | Chng, Hiok Hee | Kim, Dong Chan | Yang, Song-I | Lee, Hae Ran | Seo, An Deok | Lee, So Yeon | Artesani, Maria Cristina | Francalanci, Paola | Dahdah, Lamia | Schreiner, Thomas | Fiocchi, Alessandro | Chakraborty, Kaushik | Won, Ha Kyeong | Kim, Ju-Young | Jo, Eun-Jung | Sohn, Kyoung Hee | Kim, Kyung-Mook | Park, Heung Woo | Chang, Yoon-Seok | Cho, Sang-Heon | Song, Woo-Jung | Kim, Byung-Keun | Yonekura, Syuji | Okamoto, Yoshitaka | Hur, Gyu Young | Ye, Young Min | Kim, Joo-Hee | Jung, Ki-Suck | Kim, Junga | Shim, Jae Jeong | Park, Hae-Sim | Sekimoto, Kazuhiro | Sugai, Kazuko | Tsuchimoto, Keiji | Uehara, Hiromi | Ikeda, Masanori | Chung, Euncho | Park, Kang Seo | Choi, Yean Jung | Park, Jeewon | Hong, Soo-Jong | Lee, So Yeon | Jacquet, Alain | Buaklin, Arun | Malainual, Nat | Roopashree, S. | Kim, Kyu Rang | Kim, Mijin | Cho, Changbum | Kim, Baek-Jo | Oh, Jae-Won | Han, Mae Ja | Cho, Hyun-Ju | Shin, Youn Ho | Lee, Eun | Kim, Young-Ho | Lee, Darae | Kang, Mi-Jin | Yang, Song-I | Ahn, Kangmo | Kim, Kyung Won | Kim, Yoon Hee | Won, Hye-Sung | Kim, Soo Hyun | Choi, Suk-Joo | Kim, Young Han | Jun, Jong Kwan | Kim, Eun-Jin | Lee, Jeom Gyu | Lee, So-Yeon | Hong, Soo-Jong | Suh, Dongin | Amagai, Yosuke | Tanaka, Akane | Matsuda, Hiroshi | Mösges, Ralph | Dieterich, Pauline | Astvatsatourov, Anatoli | Hüser, Christoph | Singh, Jaswinder | Shah-Hosseini, Kija | Allekotte, Silke | Compalati, Enrico | Sohn, Kyoung Hee | Song, Woo-Jung | Kim, Byung-Keun | Kim, Ju-Young | Yang, Min Suk | Lee, So-Hee | Kim, Sae-Hoon | Kang, Hye-Ryun | Park, Heung Woo | Kim, Sun-Sin | Min, Kyung-up | Cho, Sang-Heon | Chang, Yoon-Seok | Chang, Woo-Sung | Do, Ji-Hye | Kim, Yeon-Seop | Yoon, Dankyu | Lim, Hye-Sun | Lee, Jeom-Kyu | Kim, Eun-Jin | Thong, Bernard | Cheng, Yew Kuang | Hou, Jinfeng | Leong, Khai Pang | Tan, Justina | Chia, Faith | Chan, Grace | Tan, Sze-Chin | Tan, Teck Choon | Tang, Chwee Ying | Chng, Hiok Hee | Park, Chan-Sun | Kim, Mi Yeoung | Kim, Eun-Young | Shin, Jae-Gook | Choi, Jae-Hyeog | Park, Saegwang | Kim, Yeonye | Lim, Kyung-Hwan | Jung, Jae Woo | Kang, Mingyu | Kim, Ju-Young | Kim, Ju-Young | Kim, Hyun Jeong | Woo, Yeon-Ju | Jung, Soo-Youn | Kang, Hye-Ryun | Kang, Hye-Ryun | Porée, Thierry | Boukhettala, Nabile | Furon, Emeline | Bullimore, Alan David | Heath, Matthew | Hewings, Simon | Skinner, Murray | Kurowski, Marcin | Krysztofiak, Hubert | Wardzynska, Aleksandra | Jarzebska, Marzanna | Jurczyk, Janusz | Kowalski, Marek L. | Kim, So Ri | Lee, Yong Chul | Kim, Dong Im | Rhee, Yang Keun | Lee, Heung Bum | Park, Seoung Ju | Choe, Yeong Hun Choe | Park, Seung Yong | Kim, Joo-Hee | Park, Sunghoon | Hwang, Young Il | Jang, Seung Hun | Jung, Ki-Suck | Min, Jiang | Guang-Min, Nong | Nag, Nalin | Indawati, Wahyuni | Bullimore, Alan David | Heath, Matthew | Skinner, Murray | Seo, Seong Jun | Oh, Won Jong | Bullimore, Alan David | Skinner, Murray | Heath, Matthew | Bell, Andrew | Hasanzadeh, Hournaz | Sadeghzade, Salman | Rezaei, Nima | Zarebidoki, Alireza | Cho, Kyu-Sup | Oh, Moo-Young | Kim, Sung-Woo | Koizumi, Munemitsu | Kuzume, Kazuyo | Park, Kui Young | Oh, Won Jong | Babaie, Delara | Nabavi, Mohammad | Zandieh, Fariborz | Moini, Mehrdad Amir | Chavoshzadeh, Zahra | Seifi, Hamideh | Sahragard, Mitra | Mesdaghi, Mehrnaz | Bemanian, Mohammad Hassan | Choi, Sun Young | No, Yeon a | Kiedik, Dorota | Muszynska, Agnieszka | Pirogowicz, Iwona | Fal, Andrzej M. | Motomura, Chikako | Wakatsuki, Masatoshi | Akamine, Yuko | Iwata, Mihoko | Matsuzaki, Hiroshi | Taba, Naohiko | Murakami, Yoko | Odajima, Hiroshi | Ghrahani, Reni | Takaoka, Yuri | Lee, Jong-Uk | Heo, Jeong-Seok | Bae, Da-Jeong | Song, Hyun Ji | Park, Choon-Sik | Park, Jong-Sook | Cho, Jae Hoon | Choi, Ji Ho | Febriana, Fiska | Ghrahani, Reni | Sapartini, Gartika | Setiabudiawan, Budi | Nam, Young-Hee | Kim, Mi Yeoung | Choi, Gil-Soon | Park, Chan-Sun | Huang, Chiung-Hui | Soh, Jian Yi | Shek, Lynette | Shek, Lynette | Delsing, Dianne J. | Lee, Bee Wah | Lee, Bee Wah | Goh, Si Hui | Chiang, Wen Chin | Loh, Wenyin | Yang, Hea-Kyoung | Lee, Ji Young | Kim, Minji | Ahn, Kangmo | Kim, Jihyun | Kim, Young-Min | Kim, Hye-Young | Park, Yong Mean | Kim, Woo Kyung | Lee, So-Yeon | Jeong, Jongin | Hong, Sang Duk | Chung, Seung Kyu | Dhong, Hun-Jong | Kim, Hyo Yeol | Kim, Sujin | Bak, Hana | Son, Hye-Rim | Lee, Si-Eun | Kim, Kwang-Jin | Lim, Young-Wook | Kim, Ho-Hyun | Lee, Yong-Won | Han, Man Yong | Jung, Young-Ho | Jee, Hye Mi | Lee, Seung Jin | Lee, Kyung Suk | Kim, Mi-Ae | Lee, Jaechun | Lee, Eunkyoung | Golez, Jasmina | Bae, Da-Jeong | Min, Chang-Gi | Lee, Jong-Uk | Park, Jong-Sook | Chang, Hun Soo | Park, Choon-Sik | Jang, An-Soo | Kim, Ha-Jung | Kim, Young-Joon | Jung, Bok Kyoung | Lee, Seung-Hwa | Kang, Mi-Jin | Jeong, Sekyoo | Lee, Eun | Cho, Hyun-Ju | Kim, Young-Ho | Yang, Song-I | Kim, Seo Hee | Hong, Soo-Jong | Halwani, Rabih | Al Muhsen, Saleh | Sultana, Asma | Al-Faraj, Achraf | Kanana, Rosan | Afzal, Sibtain | Al Kufaidi, Roaa | Kim, Hee-Kyoo | Oak, Chul-Ho | Choi, Gil-Soon | Moon, Ye-Jin | Park, Eun-Kee | Abrari, Mina | Amirzargar, Ali Akbar | Zarebidoki, Alireza | Ha, Mina | Hong, Soo-Jong | Seo, Ju-Hee | Kang, Mingyu | Cho, Byung-Ha | Park, Han-Ki | Park, Han-Ki | Kim, Kyung-Mook | Park, Chang-Han | Park, Heung Woo | Park, Heung Woo | Chang, Yoon-Seok | Chang, Yoon-Seok | Chang, Yoon-Seok | Song, Sook-Hee | Kim, Mi-Kyeong | Kim, Mi-Kyeong | Cho, Sang-Heon | Chang, Suk-Il | Min, Kyung-up | Min, Kyung-up | Morice, Alyn | Choi, Jungi | Han, Yusok | Park, Jin-Sung | Kwon, Eunmi | Kim, Chang-Keun | Sapartini, Gartika | Kim, Ji-Na | Shin, Seungwoo | Chang, Hun Soo | Shim, Eun-Young | Jun, Ji Ah | Lee, Hyeonju | Park, Jong-Sook | Park, Choon-Sik | Sepiashvili, Revaz | Khachapuridze, Darejan | Gamkrelidze, Sofio | Chikhladze, Manana | Lee, Seung-Eun | Kim, Yun-Seong | Jeon, Doo-Soo | Cho, Woo-Hyun | Yeo, Hye-Ju | Yoon, Seong-Hoon | Kim, Seung-Hyun | Lee, Taehyeong | Song, Hyun Ji | Park, Choon-Sik | Jun, Ji Ah | Park, Jong-Sook | Yoon, Dankyu | Kim, Yeon-Seop | Chang, Woo-Sung | Kang, Mi-Jin | Hong, Soo-Jong | Lee, Jeom-Kyu | Kim, Eun-Jin | Park, Minkee | Lee, Nanju Alice | Rost, Johanna | Muralidharan, Sridevi | Campbell, Dianne | Mehr, Sam | Lee, Seung-Hwa | Yoon, Seon-Joo | Kim, Ha-Jung | Lee, Eun | Yang, Song-I | Jung, Young-Ho | Yu, Ho-Sung | Kim, Hee-Suk | Park, Yeon Hee | Lee, So-Yeon | Park, Jun-Sung | Jun, Hyun Ok | Won, Ha Kyeong | Kang, Min-Koo | Moon, Sung Do | Kim, Byung-Keun | Kim, Ju-Young | Cho, Sang-Heon | Kang, Hye-Ryun | Shim, Ji-Su | Chung, Soo Jie | Choi, Jaehee | Ahn, Kangmo | Kim, Kwanghoon | Kim, Jihyun | Lee, Jiyoung | Park, Bo Bae | Nho, In Young | Park, Chang-Han | Kim, Jang Min | Chang, Suk-Il | Kim, Sun Kyung | Yang, Hyung Chae | Nam, Kwang Il | Lee, Jeongmin | Lee, Sooyoung | Jeong, Kyunguk | Jeon, Se-Ah | Fujiwara, Midori | Shindo, Shoko | Murota, Hiroyuki | Tahara, Mayuko | Takahashi, Aya | Katayama, Ichiro | Jung, Jae Woo | Song, Hyun Ji | Lee, Taehyeong | Jang, An-Soo | Park, Jong-Sook | Chang, Hun Soo | Park, Choon-Sik | Choi, Byoung Whui | Kim, Min-Hye | Bae, Da-Jeong | Song, Hyun Ji | Lee, Taehyeong | Jun, Ji Ah | Park, Jong-Sook | Jang, An-Soo | Chang, Hun Soo | Cho, Young Joo | Park, Choon-Sik | Mun, Sue Jean | Kuroda, Etsushi | Ozasa, Koji | Ishii, Ken | Kim, Sunmi | Park, Gyeong-Hun | Song, Hyun Ji | Lee, Taehyeong | Jun, Ji Ah | Chang, Hun Soo | Park, Jong-Sook | Park, Choon-Sik | Kim, Mi-Ae | Shin, Seungwoo | Park, Jong-Sook | Chang, Hun Soo | Cho, You Sook | Park, Hae-Sim | Park, Choon-Sik | Min, Zhang | Yoon, Seo Hee | Sol, In Suk | a Park, Young | Kim, Yoon Hee | Kim, Min Jung | Kim, Kyung Won | Sohn, Myung Hyun | Kim, Kyu-Earn | Shiquan, Wu | Lee, Yongwon | Bak, Hana | Ching, Maricar Wisco | Ramos, John Donnie | Jeong, Kyunguk | Lee, Sooyoung | Ahn, Kangmo | Sohn, Myung Hyun | Kim, Kyung Won | Lee, So-Yeon | Song, Tae Won | Jeon, Youhoon | Kim, Jihyun | Min, Taek Ki | Kim, Kyu-Earn | Pyun, Bok-Yang | Yang, Hyeon-Jong | Lee, Hae Ran | Ahn, Youngmin | Kwon, Ji-Won | Lim, Dae Hyun | Kim, Jeong Hee | Suh, Dongin | Ki, Hyung Young | Jeong, Kyunguk | Park, Byeong Sub | Lee, Sooyoung | Jeon, Se-Ah | Park, Kyu Jung | Yang, Song-I | Lee, Eun | Cho, Hyun-Ju | Kim, Young-Ho | Kang, Mi-Jin | Choi, Yean Jung | Choi, Kil Yong | Shin, Youn Ho | Ahn, Kangmo | Kim, Kyung Won | Kim, Byoung-Ju | Lee, So-Yeon | K, Eun-Jin | Dario, Roccatello | Liao, Jing | Feng, Yong | Shang, Yunxiao | Lee, Yongwon | Bak, Hana | Kim, Hyung Young | Kim, Byoung-Ju | Kwon, Ji-Won | Seo, Ju-Hee | Lee, Eun | Lee, So-Yeon | Yang, Song-I | Jung, Young-Ho | Kim, Hyo-Bin | Kwon, Ho-Jang | Park, Hee Ju | Min, Zhang | Guang-Min, Nong | Min, Jiang | Hur, Gyu Young | Sim, Eun Jung | Yoon, Sora | Choi, Juwhan | Kim, Junga | Sim, Jae Keom | Oh, Jee Youn | Jeong, Kyunguk | Park, Byeong Sub | Lee, Jeong-Min | Lee, Sooyoung | Cheon, Eunjae | Na, Youngjoo | Park, Kyu Jung | Lee, Eunjoo | Yang, William | Kelly, Suzanne | Perrins, Rob | Yang, Jimmy | Yang, William | Kelly, Suzanne | Perrins, Rob | Karsh, Jacob | Yang, Jimmy | Badellino, Hector | Teijeiro, Alvaro | Cuello, Mabel | Pereira, Marilyn Urrutia | Egues, Gustavo | Aktas, Ayse | Chun, Jin-Kyong | Mujuru, Hilda Angela | Sibanda, Elopy N. | Popescu, Andreea Ioana | Greblescu, Raluca | Rahman, Suheyla | Aktas, Ayse | Tataurshchikova, Nataly | Dissanayake, Eishika | Inoue, Yuzaburo | Shimojo, Naoki | Nakano, Taiji | Tanjung, Conny | Jensen-Jarolim, Erika | Fazekas, Judit | Singer, Josef | Lukschal, Anna | Horvat, Reinhard | Achatz-Straussberger, Gertrude | Achatz, Gernot | Fujita, Yuji | Ikegami, Shuji | Nakamura, Yoshitaka | Inoue, Yuzaburo | Shimojo, Naoki | Kohno, Yoichi | Suzuki, Shuichi | Ozawa, Naoko | Kubota, Takayuki | Nonaka, Ken | Ohara, Osamu | Masuda, Kentaro | Rhee, Chin Kook | Lee, Sook Young | Lee, Hwa Young | Lee, Hea Yon | Kang, Ji Young | Kim, Sei Won | Kwon, Soon Seog | Kim, Young Kyoon | Kim, Gun-Woo | Kim, Ju-Young | Cho, Sang-Heon | Cho, Sang-Heon | Kang, Hye-Ryun | Kang, Hye-Ryun | Kim, Hyo-Soo | Han, Jung Gyu | Lee, Jin | Lee, Ji Young | Go, Ji Young | Park, So Jung | Kim-Chang, Julie | Love, Cassandra | Lugar, Patricia | Citraresmi, Endah | Kaswandani, Nastiti | Utami, Cynthia | Said, Mardjanis | Jung, Young-Ho | Yang, Song-I | Kim, Byoung-Ju | Kwon, Ji-Won | Kim, Hwan-Cheol | Leem, Jong-Han | Seo, Ju-Hee | Kim, Hyung Young | Lee, So-Yeon | Kwon, Ho-Jang | Kim, Hyo-Bin | Cho, Hyun-Ju | Yamazaki, Susumu | Nakano, Nobuhiro | Honjoh, Asuka | Inage, Eisuke | Baba, Yosuke | Ohtsuka, Yoshikazu | Shimizu, Toshiaki | M., Ishaq | Khan, Sameera M. I. | Khan, Imran | Khan, Sabeen | Loo, Evelyn Xiu Ling | Goh, Anne | Teoh, Oon Hoe | Chan, Yiong Huak | Saw, Seang Mei | Kwek, Kenneth | Gluckman, Peter D | Godfrey, Keith M | Van Bever, Hugo | Chong, Yap Seng | Lee, Bee Wah | Shek, Lynette | Lee, Alison Joanne | Rossi, Daniela | Nemeth, Agnes | Sehlinger, Torsten | Bergmann, Karl-Christian | Goergen, Frank | Ehlayel, Mohammad S. | Bener, Abdul Bari | Chu, Hieu Chi | Do, Nga Thi Quynh | Van Nguyen, Dinh | Nguyen, Ha Thi Thu | Le, Huong Thi Minh | Van Nunen, Sheryl | Vidal, Christopher | Fernando, Suran | Psarros, Fotis | Syrigou, Ekaterini | Politi, Ekaterini | Chrysoulakis, Spyridon | Vourdas, Dimitrios | Petalas, Konstantinos | Saha, Mouli | Bhattacharya, Kashinath | Jain, Subir | Song, Xiaolian | Lin, Haiyan | Nishikawa, Kyohei | Shimada, Takashi | Yasueda, Hiroshi | Enomoto, Tadao | Aizawa, Daisuke | Kobayashi, Takayoshi | R., Chellaa | Jain, Subir | Jain, Subir | Yudina, Marina | M., Ishaq | Khan, Sameera M. I. | Khan, Imran | Khan, Sabeen | Saito, Mayako | Sari, Nurul Iman Nilam | Kim, Jae Young | Song, Jaechul | Kim, Inah | Lee, Kyeong Joon | Park, Soo Jin | Roh, Soo Yong | Billamay, Somxay | Udin, Muchammad Fahrul | Han, Mae Ja | Oh, Jae-Won | Kim, Kyu Rang | Kim, Baek-Jo | Mazza, Jorge A. | Ko, Jason Kangeun | Huang, David J. T. | Furuya, Kanae | Kainuma, Keigo | Ito, Takahiro | Nagao, Mizuho | Fujisawa, Takao | Hirayama, Junya | Kuwahara, Yu | Qualizza, Rosanna | Incorvaia, Cristoforo | Maraschini, Anna | Hasnain, Syed Mohammed | Al-Frayh, Abdulrahman | Hartog, Anita | Bastiaans, Jacqueline | Loonstra, Reinilde | Rutten, Lieke | Harthoorn, Lucien | Van Bergenhenegouwen, Jeroen | Garssen, Johan | Yoo, Kwang-Ha | Cho, Sang-Heon | Ghoshal, AG | Muttalif, Abdul Razak Bin Abdul | Lin, Horng- Chyuan | Thanaviratananich, Sanguansak | Bagga, Shalini | Faruqi, Rab | Baidya, Santwona | Taylor, Colman | Wang, De Yun | Ahn, Hae-Ryun | Hong, Soon-Kwan | Kim, Jong-Woong | Nam, Gui-Hyun | Kim, Mee-Ja | Park, Jae-Kyoung | Yi, Myung-Hee | Jeong, Kyoung Yong | Kim, Ju-Yeong | Yong, Tai-Soon | Kim, Bum Joon | Joo, Hs | Lim, Kj | Lee, Jae-Hyun | Park, Jung-Won | Yoon, Kh | Choi, DS | Joo, Hanseung | Kim, Bum Joon | Lim, Kj | Kim, MJ | Choi, DS | Yoon, Kh | Kim, Bum Joon | Joo, Hanseung | Jung, Woo Sang | Lim, Kj | Choi, DS | Lee, Ji-Hoon | Kwon, Soon-Chan | Lee, Soo-Jin | Roh, Soo Yong | Kim, Hogil | Lee, Kyeong Joon | Van De Loo, Aurora | Fernstrand, Amanda | Garssen, Johan | Verster, Joris | Van De Loo, Aurora | Garssen, Johan | Verster, Joris | Golez, Jasmina | Ozasa, Koji | Kuroda, Etsushi | Ishii, Ken | Imran, Muhammad | Gierer, Selina | Martinez, John | Wong, Lydia | Lee, Bee Wah | Yap, Gaik Chin | Llanora, Genevieve | Thong, Bernard | Shek, Lynette | Ehlayel, Mohammad S. | Soliman, Ashraf | Martins, Pedro | Marques, João | Gomes-Belo, Joana | Palmeiro, Teresa | Caires, Iolanda | Belo, Joana | Botelho, Maria Amália | Leiria-Pinto, Paula | Neuparth, Nuno | Suratannon, Narissara | Mekaroonkamol, Jaichat | Ngamphaiboon, Jarungchit | Lertchanaruengrith, Piyawadee | Chatchatee, Pantipa | Kardar, Gholamali | Majd, Ahmad | Shahali, Youcef | Ghahremaninejad, Farrokh | Pourpak, Zahra | Mousavi, Fateme | Sadeghi-Shabestari, Mahnaz | Van Bilsen, K. | Manusama, O. | Dik, W.a. | Van Der Burg, M. | Van Der Velden, V. H. J. | Dalm, V.a.S. H. | Van Hagen, P. M. | Liu, Yongping | Jeong, Yi Yeong | Kim, Ji Hye | Yoon, Moon Gyeong | Ye, Young Min | Shin, Yoo Seob | Ban, Ga Young | Park, Hae-Sim | Jung, Hye Min | Roh, Soo Yong | Song, Jaechul | Lee, Ji-Hoon | Kim, Hogil | Kim, Jae Young | Lee, Kyeong Joon | Wong, Lydia | Rajakulendran, Mohana | Santhanam, Haripriya | Shek, Lynette | Lim, Tow Keang | Kim, Hogil | Lee, Soo-Jin | Lee, Ji-Hoon | Roh, Soo Yong | Kwon, Soon-Chan | Wistiani, Ani | H, Galuh | Kardar, Gholam Ali | Sharifshoushtari, Maryam | Majd, Ahmad | Nejadsattari, Taher | Pourpak, Zahra | Moin, Mostafa | Kim, Ji Hye | Seo, Daehong | Ye, Young Min | Park, Hae-Sim | Park, Jung-Won | Lee, Jae-Hyun | Shin, Yoo Seob | Kowalski, Marek L. | Wardzynska, Aleksandra | Kurowski, Marcin | Pawelczyk, Malgorzata/Ewa | Wysokinski, Adam | Kloszewska, Iwona | Grzegorczyk, Janina | Piotrowski, Wojciech | Makowska, Joanna | Kwon, Soon-Chan | Song, Jaechul | Kim, Yong-Kyu | Bostanci, Ilknur | Emeksiz, Zeynep Sengul | Ertugrul, Aysegul | Ozmen, Serap | Sahin, Soner | Kim, Sang-Ha | Lee, Myoung Kyu | Lee, Won Yeon | Yong, Suk Joong | Lee, Seok Jeong | Jung, Ye-Ryung | Kim, Myung Shin | Park, Jong-Sook | Jang, An-Soo | Park, Choon-Sik | Wulandari, Diah Asri | Kartasasmita, Cissy | Yani, Finny Fitry | Machmud, Rizanda | Lestari, Dhina Lydia | Rusdi, Rusdi | Yurmalina, Yurmalina | Darwin, Eryati | Bostanci, Ilknur | Karacan, Gulin | Ercan, Nazli | Colak, Asuman | Alisik, Murat | Basarir, Gulay | Erel, Ozcan | Bostanci, Ilknur | Keskin, Yasemin | Lopata, Andreas/Ludwig | Zenger, Kyall | Nugraha, Roni | Kamath, Sandip | Bielory, Leonard | Georgopoulos, Panos | Zhang, Yong | Mi, Wheat | Cai, Ting | Xian, MO | Li, Jing | Feng, Mulin
Table of Contents
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
Jae-Min Shin, Heung-Man Lee, Il-Ho Park
A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines
Hyun-Sun Yoon, Gyeong Yul Park
A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome
Margit Zeher
A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendritic cells
Katsuhiko Matsui, Saki Tamai, Reiko Ikeda
A5 An evaluation of variousallergens in cases of allergic bronchial asthma at lucknow and neighbouring districts by intradermal skintest
Drsushil Suri, Dranu Suri
A6 Evaluation ferqency of ADHD in childhood asthma
Marzieh Heidarzadeh Arani
A7 Steven johnson syndrome caused by typhoid fever in a child
Azwin Lubis, Anang Endaryanto
A8 Chronic Bronchitis with Radio Contrast Media Hypersensitivity: A Case with Hypothesized GINA Step 1 Asthma
Shinichiro Koga
A9 The association between asthma and depression in Korean adult : An analysis of the fifth korea national health and nutrition examination survey (2010-2012)
Lee Ju Suk
A10 Management of allergic disease exacerbations in pregnancy
Yasunobu Tsuzuki
A11 Subcutaneous immunotherapy mouse model for atopic dermatitis
Seo Hyeong Kim, Jung U Shin, Ji Yeon Noh, Shan Jin, Shan Jin, Hemin Lee, Jungsoo Lee, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee
A12 Atopic disease and/or atopy are risk factors for local anesthetic allergy in patients with history of hypersensitivity reactions to drugs?
Fatma Merve Tepetam
A13 Food hypersensitivity in patients with atopic dermatitis in Korea
Chun Wook Park, Jee Hee Son, Soo Ick Cho, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Hye One Kim, Hee Jin Cho
A14 Anaphylaxis caused by an ant (Brachyponera chinensis) in Japan
Yoshinori Katada, Toshio Tanaka, Akihiko Nakabayashi, Koji Nishida, Kenichi Aoyagi, Yuki Tsukamoto, Kazushi Konma, Motoo Matsuura, Jung-Won Park, Yoshinori Harada, Kyoung Yong Jeong, Akiko Yura, Maiko Yoshimura
A15 Anti-allergic effect of anti-IL-33 by suppression of immunoglobulin light chain and inducible nitric oxide synthase
Tae-Suk Kyung, Young Hyo Kim, Chang-Shin Park, Tae Young Jang, Min-Jeong Heo, Ah-Yeoun Jung, Seung-Chan Yang
A16 Food hypersensitivity in patients with chronic urticaria in Korea
Hye One Kim, Yong Se Cho, Yun Sun Byun, Yoon Seok Yang, Bo Young Chung, Jee Hee Son, Chun Wook Park, Hee Jin Cho
A17 Dose optimizing study of a depigmented polymerized allergen extract of phleum pollen by means of conjunctival provocation test (CPT)
Angelika Sager, Oliver Pfaar
A18 Correlation of cutaneous sensitivity and cytokine response in children with asthma
Amit Agarwal, Meenu Singh, Bishnupda Chatterjee, Anil Chauhan
A19 Colabomycin E, a Streptomycete-Derived Secondary Metabolite, Inhibits Proinflammatory Cytokines in Human Monocytes/Macrophages
Ilja Striz, Eva Cecrdlova, Katerina Petrickova, Libor Kolesar, Alena Sekerkova, Veronika Svachova, Miroslav Petricek
A20 Intravenous immunoglobluin treatment in a child with resistant atopic dermatitis: A brief review on this therapeutic regimen
Hyuck Hoon Kwon, Kyu Han Kim
A21 Wheat allergy is difficult to diagnose then other food allergens
Suman Kumar
A22 The effects of spirulina (Arthrospira platensis) dietary supplement as an adjunct therapy for children aged 7 to 14 years old with asthma: A randomized - double blind placebo controlled clinical trial
Lou Ver Leigh Arciaga Manzon, Pilar Agnes Gonzalez Andaya
A23 The study about cause and clinicopathological findings of injection induced dermatitis
Bark-Lynn Lew, Youngjun Oh, Dongwoo Suh, Woo-Young Sim
A24 IgE reactivity of recombinant allergen pac c 3 of the Asian needle ant pachycondyla chinensis
Kyoung Yong Jeong, Myung-Hee Yi, Mina Son, Dongpyo Lyu, Jae-Hyun Lee, Tai-Soon Yong, Chein-Soo Hong, Jung-Won Park
A25 Characterization of specific IgE antibody related to antigen 5 of echinococcus granulosus
Mohammadreza Siavashi
A26 Development of binary forecast model of asthma exacerbation: Asthma index
Hey Suk Yun, Ha-Na Kang, Jae-Won Oh, Young Jin Choi
A27 Different levels in rantes, IL-5 and TNF-á between the nasal polyps of adolescents with allergic, local allergic and non-allergic rhinitis
Ha-Na Kang, Jae-Won Oh, Young Jin Choi
A28 Tgfβ1 level is associated with VDR gene polymorphism in children with allergy diseases
Tatiana Sentsova, Ilya Vorozhko, Olga Chernyak, Vera Revyakina, Anna Timopheeva, Andrey Donnikov
A29 Dynamics of immunological biomarkers in children with food allergy fed goat milk formula
Tatiana Sentsova, Ilya Vorozhko, Olga Chernyak, Vera Revyakina, Anna Timopheeva
A30 Association between obesity, abdominal obesity and adiposity and the prevalence of atopic dermatitis in young Korean adults: The korea national health and nutrition examination survey, 2008–2010
Ji Hyun Lee, Young Min Park, Sang Soo Choi, Kyung Do Han, Han Mi Jung, Young Hoon Youn, Jun Young Lee, Yong Gyu Park, Seung-Hwan Lee
A31 Associations of natural history and environmental factors with asthma among children in rural and urban areas of guangdong, China
Zhaowei Yang, Jing Li, Mulin Feng, Marjut Roponen, Bianca Schaub, Gary WK Wong
A32 The effect of CO2-enriched atmospheres to producing of allergenic pollen by ragweed
Young Jin Choi, Ha-Na Kang, Jae-Won Oh
A33 Application evaluation of house dust mite and components specific-IgE and IgG4 in specific immunotherapy with allergic diseases
Baoqing Sun, Peiyan Zheng
A34 Effect of Asian dust events on asthma according to the socioeconomic status using claim data in KOREA
Yoon-Sung Park
A35 TSLP downregulates human â-defensin 2 through STAT3-dependent pathway in keratinocytes
Sang Wook Son
A36 Effects of anti-IgE on IL-4, IL-5, IL-17, and CD19,20,200 in a case of netherton syndrome (SPINK5 mutation)
Arzu Didem Yalcin, Sukran Kose, Kemal Kiraz
A37 Augmentation of arginase 1 expression exacerbates airway inflammation in murine asthma models
Jin-Young Lee, Sehyo Yune, Jae-Won Paeng, Mi-Jung Oh, Byung-Jae Lee, Dong-Chull Choi, Young Hee Lim, Kyoung Won Ha
A38 Caregivers of children with no food allergy – their experiences and perception of the condition
Kiwako Yamamoto-Hanada, Masami Narita, Masaki Futamura, Yukihiro Ohya
A39 Evaluation of Drug Provocation Tests in Korean Children: A Single Center Experience
Jihyun Kim, Jinwha Choi, Kwanghoon Kim, Jaehee Choi, Kangmo Ahn
A40 Danyoung classification 2015 update by digital HD endoscopic evaluation
SUN-HO/Brian Chang
A41 Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy in polysensitized patients
Lisha Li
A42 Ambient desert dust and allergic symptoms: A time series analysis from a national birth cohort (JECS)
Kumiko Tsuji Kanatani, Yu-Ichi Adachi
A43 Individuals Allergic to Cow’s Milk Should be Vigilant When Consuming Beef Because It May be Injected Beef
Shigeyuki Narabayashi, Ikuo Okafuji, Yuya Tanaka, Satoru Tsuruta, Nobue Takamatsu
A44 Quality of life of chronic rhinosinusitis patients with or without nasal polyps in Korea
Soo Whan Kim, Do Hyun Kim
A45 House dust mite sensitization and exacerbation of asthma in the fall in children
Jong-Seo Yoon, Jin Tack Kim, Hwan Soo Kim, Yoon Hong Chun, Hyun Hee Kim, Sul Mui Won
A46 Evidence-based health advice for childhood eczema and household pets
Kam Lun E. Hon, Chung Mo Chow, Ting Fan Leung
A47 Relationship between allergic rhinitis and mental health in korea
Do Hyun Kim, Soo Whan Kim
A48 Oscillometric bronchodilator response in 3 to 5 years old healthy and asthmatic Filipino children
Gemmalyn Esguerra, Emily Resurreccion, Kristine Elisa Kionisala, Jenni Rose Dela Cruz
A49 The use of aeroallergen immunotherapy to treat eosinophilic esophagitis
Muhammad Imran
A50 A study of the eczema herpeticum in Korean
Yun Seon Choe, Kyu Han Kim, Mira Choi
A51 Specific sublingual immunotherapy in Korean patients with atopic dermatitis
Byung Soo Kim, Hyun-Joo Lee, Jeong-Min Kim, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Je-Ho Mun, Hoon-Soo Kim, Margaret Song, Hyun-Chang Ko, Hyun-Chang Ko, Moon-Bum Kim
A52 Association between polymorphisms in bitter taste receptors genes and clinical features in Korean asthmatics
Sun-Young Yoon
A53 Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats
Amit Kandhare
A54 A kampo formula, ogi-kenchu-to, decreases side-effects of steroid ointment for infantile atopic dermatitis: Three cases report
Noriko Yahiro
A55 To test use of jet nebulizers NE-C802 as a drug delivery system in the children with asthma
Amit Agarwal, Meenu Singh, Jasleen Kaur, Ruby Pawankar, Pankaj Pant, Sukhmanjeet Singh
A56 Immunoglobulin e to allergen components of house dust mite in Korean children with allergic disease
Hwan Soo Kim, Jong-Seo Yoon, Sul Mui Won, Yoon Hong Chun, Jin Tack Kim, Hyun Hee Kim
A57 Effectiveness of premedication and rapid desensitization in hypersensitivity to l-asparaginase
Hwan Soo Kim, Sul Mui Won, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim
A58 Angioedema with Eosinophilia: The First Report from Thailand
Thatchai Kampitak
A59 Evaluation of anti-pruritic and anti-inflammatory effects of Korean red ginseng extract on atopic dermatitis murine model
So Min Kim, Hyun Joo Lee, Hei Sung Kim, Jeong Deuk Lee, Sang Hyun Cho
A60 Subcutaneous autologous serum therapy in chronic urticaria
Kiran Godse
A61 Allergic bronchopulmonary aspergillosis in asthma and lung tuberculosis
Juwita Soekarno, Sarie Ratnasari, E. Alwi Datau, Eko Surachmanto, JC Matheos
A62 Infantile eczema is associated with campylobacter and roseburia subpopulations but not microbial diversity in stool samples of Chinese newborns
Ting Fan Leung, Jamie Sui-Lam Kwok, Christine Kit-Ching Tung, Man Fung Tang, Stephen Kwok-Wing Tsui, Gary WK Wong, Kam Lun Ellis Hon, Wing Hung Tam, Hing Yee Sy
A63 Association between serum chitinase level and toll-like receptor polymorphisms in bakery workers
Sohee Lee
A64 IFN-gamma contributes to nasal polypogenesis by inducing epithelial-to-mesenchymal transition via non-smad pathway
Hyun-Woo Shin, Mingyu Lee, Dae Woo Kim, Roza Khalmuratova
A65 Management and education status of anaphylaxis patients who visit our emergency room (ER)
Mi Yeoung Kim, Jaewon Jeong, Chansun Park
A66 Hypoallergen-Encoding DNA Plasmids As Immunoprophylactic Vaccines of Shrimp Tropomyosin Hypersensitivity
Christine Yee Yan Wai, Patrick S.C. Leung, Nicki Y.H. Leung, Ka Hou Chu
A67 The relationship between sputum pentraxin 3 levels and childhood asthma
Hee Seon Lee, Kyung Eun Lee, Jung Yeon Hong, Mi Na Kim, Min Jung Kim, Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim
A68 The role of local antibody responses in the nasal inflammation of allergic rhinitis (AR) patients
Ji Hye Kim, Hae-Sim Park, Yoo Seob Shin, Young Min Ye, Daehong Seo, Moon Gyeong Yoon, Young Mok Lee
A69 A case of ofloxacin-induced anaphylaxis by non-IgE, but specific IgG4-mediated responses
Daehong Seo, Ji Hye Kim, Young-Mok Lee, Young Min Ye, Hae-Sim Park
A70 Serum LTE4 metabolite as a biomarker for aspirin exacerbated respiratory disease
Ga Young Ban, Kumsun Cho, Seung-Hyun Kim, Yong Eun Kwon, Moon Gyeong Yoon, Ji Hye Kim, Yoo Seob Shin, Young Min Ye, Dong-Ho Nahm, Hae-Sim Park
A71 Local and systemic reactions of dust mite subcutaneous immunotherapy (SCIT) among children in a tertiary care hospital
Pilar Agnes Gonzalez Andaya
A72 Effects of carboxymethyl glucan (CM-glucan) in children with allergic rhinitis and asthma: A randomized controlled trial
Pilar Agnes Gonzalez Andaya
A73 Autophagy mechanisms in patients with severe asthma: A new therapeutic target
Ga Young Ban, Chang Gyu Jung, Seung-Ihm Lee, Duy Le Pham, Dong-Hyeon Suh, Eun-Mi Yang, Young Min Ye, Yoo Seob Shin, Hae-Sim Park
A74 Aggravation of airway inflammation and hypperresponsiveness following nasal challenge with dermatophagoides pteronyssinus in perennial allergic rhinitis patients without symptoms of asthma
Wan Jun Wang, MO Xian, Yan Qing Xie, Jing Ping Zheng, Jing Li
A75 Serum 25-hydroxyvitamin d in early childhood is non-linearly associated with allergy
Emma Merike Savilahti, Outi Mäkitie, Anna Kaarina Kukkonen, Sture Andersson, Heli Viljakainen, Erkki Savilahti, Mikael Kuitunen
A76 Fric test in dermographism
Kiran Godse
A77 Neutrophil autophagy and extracellular trap could contribute to asthma severity
Duy Le Pham, Ga Young Ban, Seung-Hyun Kim, Eun-Mi Yang, Hae-Sim Park, Ji-Ho Lee, Yong-Joon Chwae
A78 Redox Modulation for the Treatment of Toluene Diisocyanates-Induced Lung Inflammation
Li-Ming Chin, Chi-Chang Shieh
A79 A case of occupational asthma and rhinitis with anaphylaxis to Korean ginseng and sanyak
Ji Hye Kim, Hye-Soo Yoo, Moon Gyeong Yoon, Ga Young Ban, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Hae-Sim Park
A80 Factors of influencing epidermal permeability barrier defects in atopic dermatitis children
Myong Soon Sung, Jin Uck Choi, Sung Won Kim, Yong Jin Hwang
A81 Innate type 2 response to aspergillusfumigatus in a murine model of atopic dermatitis-like skin inflammation
Arum Park, Eun Lee, Song-I Yang, Hyun-Ju Cho, Jinho Yu
A82 Activin a receptor 1C may implicate in the development of sensitive skin
Dong Hun Lee, Eun Ju Kim, Yeon Kyung Kim, Eun Jin Doh, Hee Chul Eun, Jin Ho Chung, Young Mee Lee, Seon Pil Jin
A83 Genetic association and eQTL analyses of genes associated with allergy in atopic/non-atopic asthma
Xingnan Li, Naftali Kaminski, Sally Wenzel, Eugene Bleecker, Deborah Meyers
A84 Gastroscope feature and clinical characteristics in 172 cases of children with henoch-schonlein purpura
Zeng Huasong
A85 The role of TRPV1 in CD4+ t cell mediated inflammatory response of allergic rhinitis
Ji-Hun Mo, Ramachandran Samivel, Eun-Hee Kim, Ji-Hye Kim, Jun-Sang Bae, Young-Jun Chung, Dae Woo Kim
A86 A Phenotype of Rhinitis from School Children Is Associated with the Development of Bronchial Hyperresponsiveness
Eun Lee, Si Hyeon Lee, Young-Ho Kim, Hyun-Ju Cho, Ho-Sung Yu, Mi-Jin Kang, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, So-Yeon Lee, Ho-Jang Kwon, Soo-Jong Hong
A87 Increased basal activation status was noted in adult anaphylaxis patients
Sailesh Palikhe, Hae-Sim Park, Seung-Hyun Kim, Ji Hye Kim, Eun-Mi Yang
A88 Clinical values of interferon-gamma enzyme-linked immunospot assays for management of antibiotic hypersensitivity in hospitalized patients
Suda Sibunruang, Jettanong Klaewsongkram
A89 VDR gene polymorphism and 25-hydroxy vitamin d levels in children with food allergy
Tatiana Sentsova, Ilya Vorozhko, Anna Timopheeva, Olga Chernyak, Vera Revyakina, Andrey Sokolnikov
A90 An analysis of 145 oral almond challenge tests
Makoto Nisihino, Yu Okada, Noriyuki Yanagida, Motohiro Ebisawa, Sakura Sato, Kiyotake Ogura, Tomoyuki Asaumi, Kenichi Nagakura, Tetsuharu Manabe, Hirotoshi Unno
A91 Effect of creatine supplementation in fish allergenic potential; A proteomics study
Pedro M Rodrigues, Denise Schrama, Gadija Mohamed, Lizex Hüsselmann, Lizex Hüsselmann, Bongani Ndimba
A92 Flagellin modulates the function of invariant NKT cells via dendritic cells in asthma patients
Jae-Uoong Shim, Young Il Koh, Joon Haeng Rhee, Ji-Ung Jeong
A93 Clinical and subclinical manifestations of allopurinol – induced severe cutaneous adverse reactions in Vietnam
Dinh Van Nguyen, Hieu Chi Chu, Mui Thi Tran, Christopher Vidal, Suran Fernando, Sheryl Van Nunen, Sy Van Than
A94 Time course of serum inhibitory activity for facilitated allergen-IgE binding during house dust mite immunotherapy
Mulin Feng, Jing Li
A95 Periostin is a novel biomarker in eosinophilic nasal polyps of chronic rhinosinusitis
Dong-Kyu Kim, Seung-No Hong, Kyoung Mi Eun, Hong Ryul Jin, Dae Woo Kim
A96 Dominance of Th1-response in children with refractory mycoplasma pneumoniae pneumonia
Jun Bao, Yi-Xiao Bao
A97 Studies on the role of CD14 polymorphism among pollen and mold induced asthmatics of kolkata, India
Sanjoy Podder, Goutam Kumar, Shampa Dutta, Amlan Ghosh
A98 House dust mite allergy – Indian perspective
Goutam Kumar Saha, Sanjoy Podder, Salil Kumar Gupta
A99 Increased expression of purinergic (P2Y12) receptor and cysteinyl leukotriene receptors in the lung tissue of a mouse model of allergic asthma
Tu/Hoang Kim Trinh, Yoo Seob Shin, Hae-Sim Park, Jing-Nan Liu, Duy Le Pham
A100 Autologous serum skin test in chronic idiopathic urticaria - relationship with autoimmune markers and disease severity
Hyun-Chang Ko, Byung Soo Kim, Moon-Bum Kim
A101 Anxiety and depression levels in severe asthma patients treated with omalizumab
Ömer Özbudak, Fatih Üzer
A102 Economic burden of refractory chronic spontaneous urticaria on Kuwait health system
Mona Al-Ahmad, Maryam Alowayesh, Norman Carroll
A103 IgE-mediated maize allergy in India: A 28 kd protein responsible for food-induced allergic reaction
Anand Bahadur Singh
A104 Liposomal encapsulation of house dust mite allergens and dexamethasone modulates allergic response in a murine model of asthma
Yordanis Pérez-Llano, María Del Carmen Luzardo Lorenzo, Wendy Ramírez González, Carlos Calcines Cruz, Rady Laborde Quintana, Alain Morejón, Virgilio Bourg, Marilé Hechavarría Stoker
A105 Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells for Eosinophilic Rhinosinusitis with Nasal Polyps in a Mouse Model
Jun-Sang Bae, Ramachandran Samivel, Eun-Hee Kim, Ji-Hye Kim, Ji-Hun Mo
A106 Second line treatments of dermographic urticaria refractory to antihistamines
Keiko Hanaoka, Michihiro Hide, Akio Tanaka, Makiko Hiragun, Mikio Kawai
A107 Diagnostic Value of Specific IgE to Peanut and Ara h 2 in Korean Children with Peanut Allergy
Kwanghoon Kim, Kwanghoon Kim, Hye-Young Kim, Jihyun Kim, Kangmo Ahn, Youngshin Han
A108 Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema
Gun-Wook Kim, Hyun-Chang Ko, Byung Soo Kim, Moon-Bum Kim, Margaret Song
A109 Identification of an IgG1-mediated anaphylaxis marker and its application in evaluating the antigenicity of infant formulas
Takeshi Matsubara, Hiroshi Iwamoto, Yuki Nakazato, Kazuyoshi Namba, Yasuhiro Takeda
A110 Nitric oxide as a screening tool for evaluation of postoperative state of chronic rhinosinusitis
Jae Hoon Lee, Woo Yong Bae
A111 Comparison of different medical treatment options for crswnp: Doxycycline, methylprednisolone, mepolizumab, omalizumab
Els De Schryver, Lien Calus, Philippe Gevaert, Thibaut Van Zele, Claus Bachert
A112 Successful treatment of steroid resistant asthma model by blocking CD28 signal
Akio Mori, Satoshi Kouyama, Miyako Yamaguchi, Yo Iijima, Akemi Abe-Ohtomo, Hiroaki Hayashi, Kentaroh Watai, Chihiro Mitsui, Chiyako Oshikata, Kiyoshi Sekiya, Takahiro Tsuburai, Mamoru Ohtomo, Yuma Fukutomi, Masami Taniguchi
A113 Serum periostin levels was not associated with allergic rhinitis and allergic sensitization in Korean children
Ju Wan Kang, Jeong Hong Kim, Jeong Hong Kim, Keun-Hwa Lee, Hye-Sook Lee, Seong-Chul Hong, Jaechun Lee
A114 Roles of ADAM10 and ADAM17 in allergic rhinitis
Ji Won Seo, Jae Hoon Lee, Woo Yong Bae
A115 Mechanism of oral and topical polyprenol action in atopic dermatitis
Ivans Sergejs Kuznecovs, Galina Kuznecova
A116 Technical and clinical validation of a mobile chamber for allergen exposure tests
Karl-Christian Bergmann, Torsten Zuberbier, Joseph Salame, Torsten Sehlinger, Georg Bölke
A117 The association between serum lead level and total immunoglobulin e according to allergic sensitization
Yoo Suk Kim, Jung Hyun Chang, Jeong Hong Kim, Ju Wan Kang
A118 Clinical and laboratory characteristics of nasal obstruction dominant allergic sensitization
Seung-No Hong, Doo Hee Han, Chae-Seo Rhee
A119 Nasal provocation test is useful for the diagnoses of allergic, non- allergic, and local allergic rhinitis
Young-Joo Ko, Young Hyo Kim, Dae-Young Kim, Tae Young Jang
A120 Aspirin facilitates the intestinal absorption and oral sensitization of food allergens in rats
Tomoharu Yokooji, Taiki Hirano, Hiroaki Matsuo
A121 Gestational Secondhand Smoke Exposure Could Affect Maternal n-Glycosylation and Cause Filaggrin Loss in Children with Atopic Dermatitis
Galina Kuznecova, Ivans Sergejs Kuznecovs
A122 Allergen specific immunotherapy in the treatment of allergic rhinitis and asthma--a randomized prospective study from kashmir valley-north of India
Roohi Rasool Wani, Shafia Alam Syed, Ghulam Hassan, Ayaz Gul, Saniya Nissar, Zaffar Amin Shah
A123 Sleep disorders in latin-American children with asthma and/or allergic rhinitis and normal controls
Marilyn Urrutia Pereira, Carmen Fernandez, Dirceu Sole, Herberto Jose Chong Neto, Veronica Acosta, Alfonso Mario Cepeda, Mirta Alvarez Castello, Claudia Almendarez, Jose Santos Lozano Saenz, Juan C. Sisul, Nelson Rosario Filho, Antonio Castillo, Marylin Valentin Rostan, Jennifer Avila, Hector Badellino, Maria Carolina Manotas, Raúl Lázaro Castro Almarales, Mayda González León
A124 Association between respiratory symptoms and exhaled nitric oxide in Afghanistan
Woo Kyung Kim, Hae-Sun Yoon
A125 ATP, a danger signal, activates human eosinophils via P2 purinergic receptors
Takehito Kobayashi, Tooru Noguchi, Tomoyuki Soma, Kazuyuki Nakagome, Hidetomo Nakamoto, Hirohito Kita, Makoto Nagata
A126 Atopic dermatitis and sleep disorders in latin American children
Marilyn Urrutia Pereira, Dirceu Sole, Herberto Jose Chong Neto, Alfonso Mario Cepeda, Raúl Lázaro Castro Almarales, Juan C. Sisul, Marylin Valentin Rostan, Hector Badellino, Miguel Alejandro Medina Avalos, Antonio Castillo, Claudia Almendarez, Nelson Rosario Filho, Caridad Sanchez Silot, Jennifer Avila, Felicia Berroa Rodriguez, Jose Santos Lozano Saenz, Mirta Alvarez Castello, Carmen Fernandez
A127 Der p 23: A Major House Dust Mite Allergen in Spite of Limited Release from Fecal Pellets and Prominent Protease Sensitivity
Wai Tuck Soh, Alain Jacquet, Kiat Ruxrungtham, Emmanuel Nony, Maxime Le Mignon
A128 Anaphylactic Reaction After Inhalation of Budesonide
Mary Lee-Wong, Suzanne McClelland, Suzanne McClelland, Nanette B. Silverberg, Christian E. Song
A129 Lipidomic analysis of mattress dust from urban and rural schoolchildren in China
Zhaowei Yang, Jiukai Zhang, Wentao Zheng, Nanshan Zhong, Jing Li
A130 Improvements in quality of life in children with allergic rhinitis after adenotonsillectomy
Jung Ho Bae, Young Joo Cho, Joo Yeon Kim
A131 The seasonal variation of asthma exacerbations in patients allergic to pollens in Greece
Konstantinos Petalas, Dimitrios Vourdas, Christos Grigoreas
A132 Whole-genome sequencing study in allergic rhinitis nuclear families
Yuan Zhang
A133 Effect of the production of extracellular matrix from nasal fibroblasts by eosinophils activated with airborne fungi
Seung-Heon Shin, Mi-Kyung Ye, Jeong-Kyu Kim
A134 The study of clinical characteristics, lung function and bronchodilator responsiveness in infants with RSV bronchiolitis
Yong Feng, Yunxiao Shang
A135 GIS-based association between PM10 and allergic diseases in seoul: Implication for health and environmental policy
Sungchul Seo, Ji Tae Choung, Dohyeong Kim, Young Yoo, Hyunwook Lim
A136 The relationship between rhinovirus and recurrent wheezing
Wenjing Zhu, Chuanhe Liu, Li Sha, Li Chang, Min Zhao, Linqing Zhao, Yuan Qian, Yuzhi Chen
A137 Dominancy of Staphylcoccus Aureus in the Skin of Atopic Dermatitis Patients Compared to Healthy Subjects through Metagenomic Analysis
Min-Hye Kim, Young Joo Cho, Mina Rho, Jung-Won Kim, Yeon-Mi Kang, Kyung-Eun Yum, Hyeon-Il Choi, Jun-Pyo Choi, Han-Ki Park, Taek-Ki Min, Bok-Yang Pyun, Yoon-Keun Kim
A138 Micronized Cellulose Powder Reduces the Dose of Locally Applied Glucocorticoids in Patients with Allergic Rhinitis
Xueyan Wang
A139 New strategy for atopic dermatitis therapy with modulation of calcium ion channels
Woo Kyung Kim, Yu Ran Nam, Joo Hyun Nam
A140 Difference in the Systemic Bacterial Composition of Atopic Dermatitis Patients Compared to Healthy Subjects through Metagenomic Analysis of Urine
Jung-Won Kim, Min-Hye Kim, Mina Rho, Yeon-Mi Kang, Kyung-Eun Yum, Hyeon-Il Choi, Jun-Pyo Choi, Han-Ki Park, Taek-Ki Min, Young Joo Cho, Bok-Yang Pyun, Yoon-Keun Kim
A141 Occurrence and physiological function of immune complexes of food proteins and IgA in human saliva
Hiroshi Narita, Junko Hirose, Kumiko Kizu, Ayu Matsunaga
A142 Association between DNA hypomethylation at IL13 gene and allergic rhinitis in house dust mite-sensitized subjects
Jingyun Li, Yuan Zhang, Luo Zhang
A143 Effect of dietary methyl donors on asthma and atopy is modified by MTHFR polymorphism
Yean Jung Choi, Hye Lim Shin, Song-I Yang, So-Yeon Lee, Sung-Ok Kwon, Young-Ho Jung, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, Se-Young Oh, Ho-Jang Kwon, Eun Lee, Mi-Jin Kang, Soo-Jong Hong, Yun-Jeong Lee, Joonil Kim
A144 The effect of TSLP in a murine model of allergic asthma
Joon Young Choi, Ji Young Kang, Seok Chan Kim, Sei Won Kim, Seung Joon Kim, Young Kyoon Kim, Chin Kook Rhee, Hea Yon Lee, Hwa Young Lee, Sook Young Lee
A145 Evaluation of Aspirin Hypersensitivity in Chronic Rhinosinusitis Patients
Tae Kyung Koh, Sung Wan Kim, Kun Hee Lee, Chul Kwon, Joong-Saeng Jo, Sung-Hwa Dong, Young Seok Byun
A146 Chronic cough without wheezing in young children as a manifestation of chronic sinusitis
Charles Song
A147 Expression of muscarinic receptors and effect of tiotropium bromide on chronic asthma according to age in a murine model
Ji Young Kang, Hwa Young Lee, In Kyoung Kim, Sei Won Kim, Chin Kook Rhee, Seung Joon Kim, Seok Chan Kim, Sook Young Lee, Young Kyoon Kim, Soon Seog Kwon, Joon Young Choi
A148 Discrimination between non-eosinophilic and eosinophilic chronic rhinosinusitis with nasal polyps
Pona Park, Hong Ryul Jin, Dong-Kyu Kim, Dae Woo Kim
A149 Significant reduction in allergic features in the offspring of mice supplemented with specific non-digestible oligosaccharides during lactation
Astrid Hogenkamp
A150 Allergenicity assessment of hydrolysed infant formula; A multicenter comparison of a mouse model and a Guinea pig model for cow’s milk allergy
Leon Knippels, Betty C.a.m. Van Esch, Jolanda Van Bilsen, Prescilla V. Jeurink; Marjan Gros, Johan Garssen, Joost J Smit, Raymond H.H. Pieters
A151 Clinical significance between the allergic test and serum eosinophil cationic protein
Boo-Young Kim, Soo Whan Kim
A152 Hydroclorothiazide-induced acute non-cardiogenic pulmonary edema
Ramon Lleonart
A153 A Synbiotic Mixture of Scgos/Lcfos and Bifidobacterium Breve M-16V Is Able to Restore the Delayed Colonization of Bifidobacterium Observed in C-Section Delivered Infants
Christophe Lay, Kaouther Benamor, Chua Mei Chen, Jan Knol, Charmaine Chew, Voranush Chongsrisawat, Anne Goh, Wen Chin Chiang, Rajeshwar Rao, Surasith Chaithongwongwatthana, Nipon Khemapech
A154 Atopic characteristics of patients with asthma-COPD overlap syndrome
Ji Young Yhi, Sang-Heon Kim, Dong Won Park, Ji-Yong Moon, Tae Hyung Kim, Jang Won Sohn, Dong Ho Shin, Ho Joo Yoon, Seok Hyun Cho
A155 Perceptions and practices of severe asthma and asthma-COPD overlap syndrome among specialists: A questionnaire survey
Sang-Heon Kim, Ji-Yong Moon, Jae-Hyun Lee, Ga Young Ban, Sujeong Kim, Mi-Ae Kim, Joo-Hee Kim, Min-Hye Kim, Chan-Sun Park, Hyouk-Soo Kwon, Jae-Woo Kwon, Jae Woo Jung, Hye-Ryun Kang, Jong-Sook Park, Tae-Bum Kim, Heung Woo Park, You Sook Cho, Kwang-Ha Yoo, Yeon-Mok Oh
A156 A case of surgical diagnosed eosinophilic enteritis with intussusception in adult patient
Sang-Rok Lee
A157 Reference values of total IgE in estonian children
Kaja Julge, Maire Vasar, Tiia Voor, Tiina Rebane
A158 A case of eosinophilic granulomatosis with polyangiitis accompanied by rapidly progressive glomerulonephritis
Yu Jin Kim, Sang Min Lee, Shin Myung Kang, Sojeong Kim, Sun Young Kyung, Sung Hwan Jeong, Jeong-Woong Park, Hyunjung Hwang, Yong Han Seon, Sanghui Park, Sang Pyo Lee
A159 Associations Between Infectious Diseases and Urticaria
Marius Iordache
A160 Sleep in infants in korea – finding of bisq survey
Yeongsang Jeong, Sohee Eun, Byung Min Choi, Ji Tae Choung, Wonhee Seo
A161 Increased Expression of Filaggrin, TSLP, Periostin, IL13 and IL-33 in Nasal Polyps
Liang Zhang, Ruby Pawankar, Manabu Nonaka, Miyuki Hayashi, Shingo Yamanishi, Harumi Suzaki, Yasuhiko Itoh, So Watanabe, Hitome Kobayashi
A162 Asymptomatic bacteruria increases the risk of edematous attacks in patients with hereditary angioedema due to C1 inhibitor deficency (C1-INH-HAE)
Zsuzsanna Zotter, Henriette Farkas, Lilian Varga, Nora Veszeli, Eva Imreh, Gabor Kovacs, Marsel Nallbani
A163 Gastric Erosions Cause Spontaneous Urticaria Independent of Helicobacter Pylori
Semen Zheleznov, Galina Urzhumtseva, Natalia Petrova, Zhanna Sarsaniia, Nikolai Didkovskii, Torsten Zuberbier
A164 The Effect of G2 Vaccine on the Gene Expression NKG2D and Receptor Presenting on the Surface of NK Cells in Peripheral Blood
Nader Dashti Gerdabi, Ali Khodadadi, Zahra Abdoli, Mehri Ghafourian, Mohammad Ali Assarehzadegan, Khodayar Ghorban
A165 Ethnic differences in lifetime prevalence and indoor environmental factors for childhood eczema
Hyo-Bin Kim, Hui Zhou, Jeong Hee Kim, Rima Habre, Theresa Bastain, Frank Gilliland
A166 A case of methazolamide-induced toxic epidermal necrolysis
Jong-Wook Bae, Kyu-Hyung Han, Young-Koo Jee, Misoo Choi, Seung-Phil Hong, Seung-Hyun Kim
A167 Inflammatory responses of human adipose-tissue derived stem cells to LPS and nanoparticles
Hee-Kyoo Kim, Gil-Soon Choi, Jeonghoon Heo, Young-Ho Kim, Eun-Kee Park
A168 Analysis of 71 Cashew Nut Oral Challenge Tests
Takashi Inoue, Kiyotake Ogura, Noriyuki Yanagida, Hirotoshi Unno, Kenichi Nagakura, Tetsuharu Manabe, Tomoyuki Asaumi, Sakura Sato, Yu Okada, Motohiro Ebisawa
A169 Fungal sensitization is associated with asthma exacerbation
Min-Gu Kim, You Sook Cho, Tae-Bum Kim, Hee-Bom Moon, Jung-Hyun Kim, Hyo-Jung Kim, So-Young Park, Bomi Seo, Hyouk-Soo Kwon, Jaemoon Lee, Taehoon Lee
A170 Individual therapeutic patient education and consultation in children with atopic dermatitis
Hye-Soo Yoo, Jieun Kim, Inok Kim, Haejin Kim, Younhee Chang, Hae-Sim Park, Sooyoung Lee
A171 Utility of Alpha-Lactalbumin Specific IgE Levels Using Immulite 2000 3gAllergy in Predicting Clinical Severity of Milk Allergy
Kazuyo Kuzume, Munemitsu Koizumi, Koji Nishimura, Michiko Okamoto
A172 Isoniazid/rifampicin-specific t-cell responses in patients with anti-tuberculosis –induced dress syndrome
Seung-Hyun Kim, Young Min Ye, Gyu Young Hur, Hae-Sim Park, Sang-Heon Kim, Young-Koo Jee
A173 Genetic biomarkers associated with aspirin-exacerbated respiratory disease (AERD) phenotype based on genome-wide association study
Seung-Hyun Kim, Hyunna Choi, Young Min Ye, Hae-Sim Park
A174 Assessment of ORAL drug provocation test in the diagnosis of NON-steroidal ANTI-inflammatory drugs hypersensitivity
Bui VAN Khanh, Hieu Chi Chu, Nguyen Nhu Nguyet, Nguyen Hoang Phuong
A175 Korean treatment guideline of atopic dermatitis
Joo Young Roh, Hyun Jeong Kim, Jung Eun Kim, Bark-Lynn Lew, Kyung Ho Lee, Seung-Phil Hong, Yong Hyun Jang, Kui Young Park, Seong Jun Seo, Jung Min Bae, Eung Ho Choi, Ki Beom Suhr, Seung Chul Lee, Hyun-Chang Ko, Young Lip Park, Sang Wook Son, Young Jun Seo, Yang Won Lee, Sang Hyun Cho, Chun Wook Park
A176 Systemic side reaction of subcutaneous immunotherapy(SCIT) for perennial allergic rhinitis
Kun Hee Lee, Sung Wan Kim
A177 Clinical baseline characteristics of Asian patients suffering from refractory chronic spontaneous urticaria (CSU) in three phase 3 omalizumab clinical trials
Chia-Yu CHU, Derrick Aw, Young-Min Ye, Giovanni Bader, Fabrizio Dolfi, Nathalie Oliveira
A178 A metagenomic approach through t-RFLP to the microbiome of asthma
Jae Chol Choi, Jae Woo Jung, Hye-Ryun Kang, Kijeong Kim, Byoung Whui Choi
A179 Clinical characteristics and ten-year trend of peripheral blood eosinophilia among health screening program recipients at a tertiary hospital of South Korea
Jong Wook Shin, Jae Woo Jung, Jae Chol Choi, In Won Park, Byoung Whui Choi, Jae Yeol Kim
A180 The prevalence of toxocariasis and diagnostic value of serologic tests in asymptomatic Korean adults
Jin-Young Lee, Kyoung Won Ha, Yun-Jin Jeung, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi, Mi-Jung Oh, Young Hee Lim
A181 Cutaneous Drug Hypersensitivity Reaction in Korean Children: An Analysis of KAERS Database on 2012-2013
Eui Jun Lee, Dongin Suh, Sung-Il Woo, Hwa Jin Cho, Eun Hee Chung, Soo Youn Chung
A182 Comparison of clinical characteristics, quality of life and sleep in patients with allergic rhinitis when categorised as “sneezers and runners” and “blockers”
Kamal Gera, Ashok Shah
A183 Role of s-nitrosoglutathione reductase (GSNOR) in the murine strain differences of airway hyperresponsiveness
Jin-Young Lee, Kyoung Won Ha, Mi-Jung Oh, Young Hee Lim, Sehyo Yune, Jae-Won Paeng, Mi-Jin Jang, Byung-Jae Lee, Dong-Chull Choi
A184 Protection from airway bronchoconstriction by gsno
Jin-Young Lee, Mi-Jin Jang, Jae-Won Paeng, Yun-Jin Jeung, Young Hee Lim, Mi-Jung Oh, Kyoung Won Ha, Byung-Jae Lee, Dong-Chull Choi, Sehyo Yune
A185 Does EIA-targeted asthma treatment improve daily physical activity of children?
Takahiro Ito
A186 Wheezing as a clue to the diagnosis of cough variant asthma and nonasthmatic eosinophilic bronchitis
Jihye Kim, Jin-Young Lee, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi, Mi-Jin Jang, Jae-Won Paeng, Young Eun Kim, Young Nam Kim, Yongseok Lee
A187 Antagonism of microRNA-21 suppressed the airway inflammation in a mouse model of bronchial asthma
Hwa Young Lee, Sook Young Lee, Soon Seog Kwon, Young Kyoon Kim, Chin Kook Rhee, Sei Won Kim, Hea Yon Lee, Joon Young Choi, In Kyoung Kim
A188 Chlorhexidine anaphylaxis: A report of two cases
Jose Antonio Navarro, Maria Ascension Aranzabal, Alejandro Joral, Susana Lizarza, Miguel Echenagusia, EVA Maria Lasa
A189 Effects of Particulate Matter on Respiratory Allergic Diseases Considering Meteorological Factors in Busan, Korea
Eun-Jung Jo, Sun-Mi Jang, Seung-Eon Song, Hae-Jung Na, Chang-Hoon Kim, Woo-Seop Lee, Hye-Kyung Park
A190 Clinical characteristics of neutrophilic asthma
Sachiko Miyauchi, Yoshitaka Uchida, Tomoyuki Soma, Susumu Yamazaki, Toru Noguchi, Takehito Kobayashi, Kazuyuki Nakagome, Makoto Nagata
A191 Current Practice of Infants and Children with Acute Urticaria at a Single Wide Regional Emergency Medical Center
Hea Lin Oh, Do Kyun Kim, Dongin Suh, Young Yull Koh
A192 Discordance between sputum eosinophilia and exhaled nitric oxide
Sehyo Yune, Jin-Young Lee, Byung-Jae Lee, Dong-Chull Choi, Jae-Won Paeng, Mi-Jin Jang, Jihye Kim, Young Nam Kim
A193 Association between genetic polymorphisms of costimulatory molecules and antituberculosis drugs induced hepatitis
Sang-Heon Kim, Sang-Hoon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Jae Hyung Lee, Byoung Hoon Lee, Youn-Seup Kim, Jae-Seuk Park, Young-Koo Jee
A194 The prevalence of gastroesophageal reflux disease in chronic unexplained cough
Sehyo Yune, Jin-Young Lee, Jae-Won Paeng, Mi-Jin Jang, Dong-Chull Choi, Byung-Jae Lee, Yongseok Lee, Young Eun Kim
A195 Risk Factors of Allergic Rhinitis in Preschool Children and Clinical Utility of Feno
Jisun Yoon
A196 Relationship between serum 25-hydroxyvitamin d and asthma exacerbation severity in children
Yong Feng, Li Zhang, Xuxu Cai
A197 Usefulness of Specific IgE Antibody Levels to Wheat, Gluten and Ï-5 Gliadin for Wheat Allergy in Korean Children
Jong-Seo Yoon, Kyunguk Jeong, Hye-Soo Yoo, Sooyoung Lee, Sooyoung Lee
A198 Neutralization of stratum corneum accelerates the progress from atopic dermatitis to asthma-like lesion in flaky tail mice treated by house dust mite allergen
Hae-Jin Lee, Noo Ri Lee, Bo-Kyung Kim, Minyoung Jung, Dong Hye Kim, Catharina S. Moniaga, Kenji Kabashima, Eung Ho Choi
A199 Trends in oral food challenges in Japan: A six-year prospective study
Noriyuki Yanagida, Sakura Sato, Chizuko Sugizaki, Motohiro Ebisawa
A200 The Gut Microbiome in the Food Allergic Host
Jamie Kiehm, Punita Ponda, Sherry Farzan, Jared Weiss, Claudia Elera, Catherine Destio, Cristina Sison, Annette Lee
A201 Cord blood cytokines and maternal environmental exposure during pregnancy
Soo Hyun Ri, Chang Hoon Lim
A202 Rupatadine pharmacokinetics in Japanese healthy volunteers after single and repeated oral doses of 10, 20 and 40 mg
Iñaki Izquierdo Pulido, Jorg Taubel, Georg Ferber, Eva Santamaria Masdeu
A203 A safe and effective method to desensitize patients with wheat allergy
Alireza Khayatzadeh, Masoud Movahedi, Motohiro Ebisawa, Mohammad Gharagozlou
A204 RNA Binding Protein Hur Regulates CD4+ T Cell Differentiation and Is Required for Allergic Airway Inflammation and Normal IL-2 Homeostasis
Ulus Atasoy, Patsharaporn Techasintana, Matt Gubin, Jacqueline Glascock, Suzanne Ridenhour, Joseph Magee
A205 Time Trends in the Epidemiology of Recurrent Wheezing in Infants from South America
Nelson Rosario Filho; Herberto Jose Chong Neto, Gustavo Falbo Wandalsen, Ana Caroline Dela Bianca, Carolina Aranda, Dirceu Sole, Javier Mallol, Luis Garcia-Marcos, Luis Garcia-Marcos
A206 Successful Cyclophosphamide Desensitization in a Pediatric Patient with Systemic Lupus Erythematosus
Jennifer Toh, Yoomie Lee, Joyce Huang, Elina Jerschow, Jenny Shliozberg
A207 The Fatty Acid Binding Protein Der p 13 Is a Minor House Dust Mite Allergen Able to Activate Innate Immunity
Pattraporn Satitsuksanoa, Narissara Suratannon, Jongkonnee Wongpiyabovorn, Pantipa Chatchatee, Kiat Ruxrungtham, Alain Jacquet
A208 Epidemiology of Stevens-Johnson Syndrome and Toxic Epidemal Necrolysis: An Administrative Database Study
Min Suk Yang; Jin Yong Lee, Ja Yeun Kim, Han-Ki Park, Ju-Young Kim, Woo-Jung Song, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Sang-Heon Cho, Kyung-up Min, Chang-Han Park, Suk-Il Chang, Sook-Hee Song
A209 Regional Differences of Vitamin D and Food-Induced Anaphylaxis in Korea
Si-Heon Kim, Gil-Soon Choi, Su-Chin Kim, Ji Hye Kim, Ga Young Ban, Yoo Seob Shin, Hae-Sim Park, Young Min Ye
A210 Triggering Factors of Atopic Dermatitis By Severity
Yoon Ha Hwang
A211 Clinical Features of Adverse Drug Reactions of Monoclonal Antibodies in Korea
Da Woon Sim, Kyung Hee Park, Kyung Hee Park, Hye Jung Park, Hye Jung Park, Jung-Won Park, Jung-Won Park, Jae-Hyun Lee, Jae-Hyun Lee
A212 Food Allergy with Eczema Is Associated with Reduced Growth in the First Four Years of Life
Katrina Allen, Cara Beck, Jennifer Koplin, Melanie Matheson, Mimi Tang, Anne-Louise Ponsonby, Lyle Gurrin, Shyamali Dharmage, Melissa Wake, Vicki Mcwilliam
A213 The Preliminary Study on Clinical Efficacy and Impact Factors of One Year’s Dust Mite Specific Immunotherapy in Allergic Asthma and Rhinitis Children Sensitized to Dust Mite
Xiaoying Liu, Jing Wang, Li Xiang, Qun Wang
A214 Lipopolysaccharide Signaling through Toll- like Receptor 4 Could be Augmented By Dermatophagoides Farinae in the Human Middle Ear Epithelial Cell
Ji-Eun Lee, Dong-Young Kim, Chae-Seo Rhee, Chae-Seo Rhee
A215 Drug Allergy in Pregnant Adolescents: Relation with Familial and Personal Atopy, and Substances Use
Francisco Vazquez-Nava
A216 Patients and Physicians Concept of Well-Controlled Asthma: Findings from Realise Asia
Sang-Heon Cho, Jaewon Jeong, Diahn-Warng Perng, David Price, Glenn Neira, Jiangtao Lin
A217 The Role of Vasoactive Intestinal Peptide in the Pathophysiology of Acute Asthma
Olga Semernik
A218 Comparison of Serum Cytokine Levels According to the Severity in Atopic Dermatitis
Ha-Su Kim, Jin-a Jung, Ji-in Jung
A219 The Different Influence on the Regulatory T Cell Response Between Subcutanous Immnuotherapy(SCIT) and Sublingual Immunotherapy(SLIT) in Children with Asthma
Qing Miao, Li Xiang
A220 Asthma State of Affairs in Asia: Seeing through Physicians’ and Patients’ Lenses
Sang-Heon Cho, Jaewon Jeong, Diahn-Warng Perng, Jiangtao Lin, David Price
A221 Identification of Aspirin Exacerbated Respiratory Disease (AERD) Phenotypes Using Two Step Cluster Analysis
Hyun Young Lee, Hae-Sim Park, Young Min Ye, Su Chin Kim
A222 Dusty Air Pollution Are Associated with an Increase Risk of Allergic Diseases in General Population
Shokrollah Farrokhi, Mohammadkazem Gheiby
A223 A Genome-Wide Association Study of Antituberculosis Drugs-Induced Hepatitis
Sang-Heon Kim; Heung Woo Park, Sang-Hoon Kim, Young-Koo Jee
A224 The Role of peroxiredoxin6 of Bronchial Epithelial Cells in Regulating Mitochondrial Function Under Oxidative Stress By Translocation to Outside Mitochondrial Membrane
Sunjoo Park, Keun Ai Moon, Hyouk-Soo Kwon, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Kyoung Young Lee, Gyong Hwa Hong, Eun Hee Ha
A225 Toxic and Adjuvant Effects of 3 Types of Silica Nanoparticles on Airway System
Heejae Han, Hye Jung Park, Yoon Hee Park, Yoon-Jo Kim, Kangtaek Lee, Jung-Won Park, Jae-Hyun Lee
A226 Procedure for Diagnostic and Selection of Immunotherapy Method for Children with Different Immunopathogenetic Phenotypes of Atopic Dermatitis
Tatiana Slavyanskaya, Vladislava Derkach
A227 Prediction of the Success of Our Desensitization Protocol with Symptoms and Results of a Skin Prick Test in Patients with Hypersensitivity to Platinum-Based Chemotherapy
Hye Jung Park, Chein-Soo Hong, Jae-Hyun Lee, Jae-Hyun Lee, Sungryeol KIM, Sungryeol KIM, Kyung Hee Park, Kyung Hee Park, Choong-Kun Lee, Beodeul Kang, Seung-Hoon Beom, Sang Joon Shin, Minku Jung, Jung-Won Park, Jung-Won Park
A228 Anti-Allergic Effect of Intralymphatic Injection of OVA-Flagelin Mixture in Mouse Model of Allergic Rhinitis
Eun-Hee Kim, Ji-Hye Kim, Ji-Hun Mo, Young-Jun Chung
A229 Serum Periostin Level Is Higher in Respiratory Type of NSAID Hypersensitivity Than Cutaneous Type
Mi-Ae Kim, Hae-Sim Park, Moon Gyeong Yoon, Young-Soo Lee, Ji Hye Kim, Ga Young Ban, Hye-Soo Yoo, Yoo Seob Shin, Young Min Ye, Dong-Ho Nahm
A230 A Retrospective Analysis of Allergy Blood Testing in Beijing Children’s Hospital in the Year of 2013: A Single-Center Research
Qing Miao, Li Xiang
A231 Role of Nrf2 in the Allergic Airway Inflammation Differ Between BALB/c and C57BL/6 Mice
Ying-Ji Li, Takako Shimizu, Hirofumi Inagaki, Yukiyo Hirata, Hajime Takizawa, Arata Azuma, Masayuki Yamamoto, Tomoyuki Kawada
A232 Effect of Human Mesenchymal Stem Cell on Neutrophilic Asthma Model
Min-Gu Kim, Gyong Hwa Hong, Kyoung Young Lee, Eun Hee Ha, Keun Ai Moon, Sunjoo Park, Hyouk-Soo Kwon, Tae-Bum Kim, Hee-Bom Moon, You Sook Cho, Jung-Hyun Kim, Hyo-Jung Kim, So-Young Park, Bomi Seo
A233 Immunomodulatory Effect of Tonsil Derived Mesenchymal Stem Cells in a Mouse Model of Allergic Rhinitis
Ji-Hye Kim, Ramachandran Samivel, Eun-Hee Kim, Young-Jun Chung, Ji-Hun Mo
A234 Alternative Therapy Such As Yoga May be a Low Cost Tool for Improving the Quality of Life of Patient’s with Allergic Rhinitis and Asthma
Soumya M. S., G. Inbaraj, R. Chellaa, Ruby Pawankar
A235 Substantial Impairment of the Quality of Life in Adult Patients with Chronic Urticaria
Wonsun Choi, Hae-Sim Park, Young Min Ye, Ji Hye Kim, Ga Young Ban, Yoo-Seob Shin
A236 Dietary Galacto-Oligosaccharides Reduce Airway Eosinophilia and Enhance the Th2 Suppressive Effect of Budesonide in House Dust Mite-Induced Asthma in Mice
Saskia Braber, Kim Verheijden, Aletta Kraneveld, Johan Garssen, Linette Willemsen, Gert Folkerts
A237 Production and Characterization of Recombinant Periplaneta americana Allergens for Component Resolved Diagnosis
Stephanie Eichhorn, Fatima Ferreira, Isabel Pablos, Bianca Kastner, Bettina Schweidler, Sabrina Wildner, Peter Briza, Jung-Won Park, Naveen Arora, Stefan Vieths, Gabriele Gadermaier
A238 Assessment of Characteristics of Itch in Patients with Hand Eczema
Sung-Min Park, Won-Ku Lee, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Hoon-Soo Kim, Margaret Song, Hyun-Chang Ko, Moon-Bum Kim, Byung Soo Kim
A239 The Hidden Culprit: A Case of Repeated Anaphylaxis from Cremophor Hypersensitivity.
Young Nam Kim, Sehyo Yune, Jin-Young Lee, Jihye Kim, Young Eun Kim, Jae-Won Paeng, Mi-Jin Jang, Dong-Chull Choi, Byung-Jae Lee, Yongseok Lee
A240 Spectrum of Anaphylaxis in Children and Adults at Emergency Departments in Singapore
Si Hui Goh, Bee Wah Lee, Jian Yi Soh
A241 Improved Quality of Life through an Integrated Health Care Service for Children with Atopic Dermatitis
Hyungoo Kang; Hyunhee Kim; Hye-Yung Yum
A242 Criteria Combining Autologous Serum Skin Test and Clusterin for Predicting Antihistamine-Refractoriness in Patients with Chronic Spontaneous Urticaria
Young Min Ye; Hae-Sim Park; Ga-Young Ban; Ji Hye Kim; Yoo Seob Shin
A243 Urinary Leukotriene E4 Levels in Wheezing Infants
Takumi Takizawa, Masahiko Tabata, Akira Aizawa, Hisako Yagi, Yutaka Nishida, Hirokazu Arakawa, Akihiro Morikawa, Solongo Orosoo
A244 Allergic Sensitization to Whey in Mice Is Facilitated By the Mycotoxin Deoxynivalenol (DON)
Saskia Braber, Marianne Bol-Schoenmakers, Peyman Akbari, Prescilla V. Jeurink, Prescilla V. Jeurink, Priscilla De Graaff, Joost J. Smit, Betty C. A. M. Van Esch, Johan Garssen, Johan Garssen, Johanna Fink-Gremmels, Raymond H. H. Pieters
A245 How to Define Chronic Cough: Based on a Systematic Review of the Epidemiological Literature
Gun-Woo Kim, Eun-Jung Jo, Sujeong Kim, Woo-Jung Song, Yoon-Seok Chang, Shoaib Faruqi, Ju-Young Kim, Mingyu Kang, Min-Hye Kim, Jana Plevkova, Heung Woo Park, Sang-Heon Cho, Alyn Morice, So-Hee Lee, Sun-Sin Kim, Seoung-Eun Lee
A246 Asko Study: Comparison of Behavior and Habits in Diagnosis and Treatment of Adult Asthma and COPD Patients
Bilun Gemicioglu, Zeynep Misirligil, Arif Hikmet Cimrin, Hakan Gunen, Tevfik Ozlu, Aykut Cilli, Levent Akyildiz, Hasan Bayram, Esra Uzaslan, Oznur Abadoglu, Mecit Suerdem
A247 Changes in Pulmonary Function in the Treatment of Obesity in Children
Keigo Kainuma
A248 Changes of Feno and Nasal Feno Levels after Treatment in Pediatric Allergic Rhinitis
Hyun-a Kim, Ha-Su Kim, Woo Yong Bae, Jin-a Jung
A249 Prevalence of Vitamin D Deficiency in Exclusively Breastfed Infants in Kenya
Rose Kamenwa, William Macharia, Nusrat Said
A250 In-Vitro Screening of Atopy in the Indian Population: Are Current Methods Adequate, Keeping Local IgE Seroprevalence for Common Food & Inhalant Allergens in Mind?
Vidya Nerurkar, Meenal Patel, Simi Bhatia
A251 Usefulness of House Dust Mites Nasal Provocation Test in Asthma
Inseon S Choi, Soo-Jeong Kim, Joo-Min Won, Myeong-Soo Park
A252 Biomarker-Based Treatment Option for Preschool Children with Recurrent Wheeze
Mizuho Nagao
A253 Anti-Tuberculosis Drugs-Induced Liver Injury in Patients with Connective Tissue Diseases
Dong Won Park, Jang Won Sohn, Ji Young Yhi, Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Dong Ho Shin, Ho Joo Yoon
A254 Ocular Symptoms of Cedar Pollinosis in Otolaryngology Patients
Yukiyoshi Hyo
A255 The Clinical Characteristics of Adverse Drug Reactions Reported in a Regional University Hospital for 6 Years and the Suggestions for the Reporting System
Jaechun Lee, Su Hee Kim, Eunkyoung Lee
A256 Changes in Skin Prick Test Results over 3 Years in School-Aged Children
Hahn Jin Jung, Jaehyun Lim, Seung-No Hong, Doo Hee Han, Chae-Seo Rhee
A257 The Analysis of Risk Factors and Features of Food Allergy in Korean Children: Nationwide Cross-Sectional Survey
Kun Song Lee
A258 A Sequential Indirect-Direct Bronchial Provocation Test for Diagnosis of Asthma: A Pilot Study
Jaechun Lee, Sun Young Yang, Mi Young Ahn, Jong Hoo Lee, Jasmina Golez
A259 Association of VDR and CYP2R1 Polymorphisms with Persistent Allergic Rhinitis in a Han Chinese Population
Hui-Qin Tian, Lei Cheng, Xin-Yuan Chen
A260 Associations of Metabolic Syndrome with Asthma and Atopy in Korean Adults
Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Ji Young Yhi, Ho Joo Yoon, Jang Won Sohn, Dong Ho Shin, Dong Won Park
A261 Clinical Manifestation and Treatment Outcome of Eosinophilic Gastroenteritis in Korean Children
Won Im Cho, Jong Sub Choi, Dongin Suh, Gyeong Hoon Kang, Jin Soo Moon, Jae Sung Ko, Kyung Jae Lee, Shin Jie Choi
A262 The Sensitization Model and Correlation of Bermuda and Timothy Grass Pollen Allergen in Allergic Patients in Southern China
Wenting Luo, Baoqing Sun
A263 A Pilot Study on the Outcomes of Respiratory Allergic Diseases at Pre-School Age in Chinese Infants with Atopic Dermatitis
Qi Gao, Li Xiang, Kunling Shen
A264 Activation of Toll like Receptor 1 and 6 By House Dust Mite Enhances the Expression of Tight Junction Protein in Epidermal Keratinocytes
Yong Hyun Jang
A265 Pollen Exposure in a Mobile Exposure Chamber: Comparing Real-Life Symptoms with Exposure Symptoms
Karl-Christian Bergmann, Torsten Sehlinger, Georg Bölke, Uwe Berger, Torsten Zuberbier
A266 Retrospective Analysis of the Incidence of Allergy in Patients with Contact Eczema
Joanna Kolodziejczyk, Milena Wojciechowska, Anna Hnatyszyn-Dzikowska, Micha Chojnacki, Zbigniew Bartuzi
A267 Effect of Fungal Sensitization in Patients with Severe Asthma
Katsunori Masaki, Koichi Fukunaga, Takashi Kamatani, Kengo Ohtsuka, Takae Tanosaki, Masako Matsusaka, Takao Mochimaru, Hiroki Kabata, Soichiro Ueda, Yusuke Suzuki, Katsuhiko Kamei, Koichiro Asano, Tomoko Betsuyaku
A268 SCIg Patient Preference Pump Versus Push
Karlee Trafford
A269 Fixed Drug Eruption Induced By Ornidazole and Diclofenac
Ismet Bulut, Zeynep Ferhan Ozseker
A270 Transepidermal Water Loss Measurement during Infancy Can Predict the Subsequent Development of Atopic Dermatitis
Kenta Horimukai, Hideaki Morita, Masami Narita, Hironori Niizeki, Kenji Matsumoto, Yukihiro Ohya, Hirohisa Saito, Shigenori Kabashima, Mai Kondo, Eisuke Inoue
A271 Inhalant Allergens on Soft Toys: A Literature Review
Robert Siebers, Francis FS Wu
A272 Fractional Exhaled Nitric Oxide in Elderly Asthmatics
Robert Siebers, Francis FS Wu, Ming-Hui Ting, Hung-En Laio, Tsung-Huai Kuo, Pei-Yuan Lee
A273 Dye and Preservative Challenge in Meal-Associated Urticaria and Angioedema: A Low-Yield Diagnostic Maneuver
Daniel Eugene Maddox
A274 The Changes of Allergic Sensitization with Age in Children with Allergic Rhinitis
Gwanghui RyuHyo Yeol Kim, Hun-Jong Dhong, Sang Duk Hong, Seung-Kyu Chung
A275 Component-Specific IgE and IgG4 Levels in Milk Allergy Children Tolerated Baked Milk Products
Osamu Higuchi, Yu-Ichi Adachi, Toshiko Itazawa, Yoko Adachi, Miki Hamamichi, Motokazu Nakabayashi, Yasunori Ito, Takuya Wada, Gyoukei Murakami, Miki Takao, Junko Yamamoto
A276 Serum Surfactant Protein(SP)-D Level: A Potential Biomarker for Aspirin-Exacerbated Respiratory Disease
Hyun Jung Jin, Moon Gyeong Yoon, Young Min Ye, Yoo-Seob Shin, Seung-Hyun Kim, Hae-Sim Park
A277 Clinical Characteristics of Anaphylaxis in Korean Children
Taek-Ki Min, Bok-Yang Pyun, So-Yeon Lee, Hyun Hee Kim, Gwang-Cheon Jang, Jinho Yu, Dongin Suh, Sooyoung Lee, Yong Mean Park, Jeong Hee Kim, Hye-Yung Yum, Kyung Won Kim, Hyeon-Jong Yang, Kangmo Ahn, Ji-Won Kwon, Myung Hyun Sohn, Hae Ran Lee, Jung Hyun Kwon, Kyu-Earn Kim, Soo-Jong Hong
A278 Immunological Changes Induced By Intramuscular Injections of Autolologous Immunoglobulin in Patients with Severe Atopic Dermatitis
Su-Mi Cho
A279 Identification of Subtypes in Subjects with Mild to Moderate Airflow Limitation and Their Clinical and Socioeconomic Implications
Jin Hwa Lee, Chin Kook Rhee, Hye Yun Park, Woo Jin Kim, Yong Bum Park, Kwang-Ha Yoo
A280 Cephalosporin-Induced Dress (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome in a 7-Year-Old Boy
Heejeong Kang, Hyeon-Jong Yang, Taek-Ki Min, Bok-Yang Pyun
A281 Maternal Depression Is Associated with Children’s Asthma : An Analysis of the Fifth Korea National Health and Nutrition Examination Survey (2010-2012)
Lee Ju Suk, Cheol Hong Kim
A282 Increased Length of Hospitalization Associated with Infiltration on Chest Radiography in Pediatric Asthma Patients
Jung Hyun Kwon, Sang Hyun Lee, Wonhee Seo
A283 A Case of 16-Year-Old Boy with Smoking-Induced Acute Eosinophilic Pneumonia
Kang-in Kim, Young Cheon Park, Hyeon-Jong Yang, Taek-Ki Min; Bok-Yang Pyun
A284 A Case of Pranlukast Induced Anaphylactic Shock
Sujeong Kim, Sun Jin, Jong-Myung Lee, Hye-Jin Jung, Jung-Wha Park
A285 Comparison of Asthma-Related Outcomes Between Metabolically Healthy Obese and Metabolically Unhealthy Obese Asthma Patients
Hyo-Jung Kim, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon, So Young Park, So-Young Park, Jung-Hyun Kim, Bomi Seo, Min-Gu Kim, Youn Yee Kim
A286 Rick Factors Associated with Longer Length of Stay in Infants Hospitalized with Respiratory Syncytial Virus Bronchiolitis
Yena Lee, Taek-Ki Min, Hyeon-Jong Yang, Bok-Yang Pyun, Suk Hee Han, Suyeon Park, Jeongho Lee, Won-Ho Hahn
A287 Urinary Excretion of 9α, 11Î2-Prostaglandin F2 and Leukotriene E4 in Patients with Exercise-Induced Bronchoconstriction
Youhoon Jeon, Joo-Hee Kim, Tae-Rim Shin, Cheol-Hong Kim, In-Gyu Hyun, Jeong-Hee Choi
A288 The Aeroallergen Sensitization Pattern and Effect on Airway Hyperresponsiveness in Busan, Korea
Sun-Mi Jang, Hae-Jung Na, Seung-Eon Song, Hye-Kyung Park, Eun-Jung Jo
A289 Multicenter Questionnaires on Current Management of Atopic Dermatitis Among Korean Patients and Caregivers
Dong Hun Lee, Jin-Young Lee, Yang Park, Jae-Won Oh, Mi Hee Lee, Soo-Jong Hong, Soo-Jong Hong, So-Yeon Lee, Joon Soo Park, Dong-Ho Nahm, Hye-Yung Yum, Hye-Yung Yum
A290 Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea
Kyu Young, Dong-Young Kim
A291 De-Labeling Beta-Lactam Hypersensitivity: An Experience from a Tertiary Care Hospital in Thailand
Sirinoot Palapinyo; Jettanong Klaewsongkram
A292 Sonic Hedgehog Signaling: Evidence for Its Protective Role in Endotoxin Induced Acute Lung Injury Mouse Model
Xing Chen, Yuting Jin, Xiaoming Hou, Fengqin Liu, Chunyan Guo, Yulin Wang
A293 Analyses of the Factors behind the Negative Attitudes Toward the Administration of Adrenaline Auto-Injectors in School Settings
Ikuo Okafuji, Yuya Tanaka, Shegeyuki Narabayashi, Satoru Tsuruta
A294 Low Vitamin D Levels Are Related to High House Dust Mite Sensitization in Patients with Severe Atopic Dermatitis
Yong Hyun Jang
A295 Appendicular Skeletal Muscle Mass Index: A Potential Predictor of Skeletal Muscle Abnormality According to the Severity Airflow Limitation of COPD
Jun-Hong Ahn, Dong-Won Lee, Jin Hong Chung, Hyun Jung Jin, Min-Su Sohn
A296 Etiology and Clinical Feature of Oral Allergy Syndrome in Children
Young a Park, Kyunguk Jeong, Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Sooyoung Lee
A297 Traffic-Related Pollution Levels and Poorly Controlled Asthma in Adults
Ho Kim, Ja Yeun Kim
A298 Anaphylaxis in Korean Children, 2009-2013 : Triggers of Anaphylaxis By Age Groups
So-Yeon Lee, Taek-Ki Min, Tae-Won Song, Kangmo Ahn, Jihyun Kim, Gwang-Cheon Jang, Hyeon-Jong Yang, Bok-Yang Pyun, Ji-Won Kwon, Myung Hyun Sohn, Kyu-Earn Kim, Jinho Yu, Soo-Jong Hong, Jung-Hyun Kwon, Sung-Won Kim, Sooyoung Lee, Woo Kyung Kim, Hyung Young Kim, Hye-Young Kim, Youhoon Jeon
A299 Maternal Allergy Is Associated with Acute Bronchiolitis Severity in Infant
Chang Hoon Lim, Yeongsang Jeong, Su Jung Kim
A300 Evaluation of Inflammatory Mediator Profiles in Sputum of Asthmatics As an Endotype for Refractory Asthma
Hun Soo Chang, Jeong-Seok Heo, Da-Jeong Bae, Jong-Uk Lee, Ji-Na Kim, Chang-Gi Min, Hyun Ji Song, Jong-Sook Park, Soo Hyun Kim, Choon-Sik Park
A301 Autophagy Is Associated with the Severity of Asthma in an Ovalbumin-Specific Mouse Model of Allergic Asthma
Jing-Nan Liu, Youngwoo Choi, Yoo Seob Shin, Hae-Sim Park
A302 Interleukin-9 and Interleukin-33 Levels in Children with Asthma
Nima Rezaei, Sedigheh Bahrami Mahneh, Arezou Rezaei, Maryam Sadr, Masoud Movahedi
A303 Pediatric Anaphylaxis at a University Hospital in Cheonan, Korea, 2013~2014
Jun Seak Gang, Joon Soo Park, Seung Soo Kim, Hyun Ho Bang, Kyeong Bae Park, Hye Sun Kim, Tae Ho Kim, Young Hwangbo, Hyun Jung Lee, Gyeong Hee Yoo, Young Chang Kim
A304 Initial Antigen-Specific IgE Levels Predict Clinical Outcome of Rush Oral Immunotherapy for Food Anaphylaxis
Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa
A305 ABCC4 gene Polymorphism Is Associated with High Periostin Levels in Asthmatic Patients
Sailesh Palikhe, Hae-Sim Park, Seung-Hyun Kim, Ri-Yeon Kim, Eun-Mi Yang
A306 The Role of Clinical Phenotype and Allergen Sensitization at 2 Years As Predictors of Atopic Disorders at 5 Years
Li Yuan Gabriella Nadine Lee, Marion Aw, Marion Aw, Bee Wah Lee, Bee Wah Lee, Evelyn Xiu Ling Loo, Yiong Huak Chan, Lynette Shek, Lynette Shek, I-Chun Kuo, I-Chun Kuo, Phaik Ling Quah, Phaik Ling Quah, Genevieve Llanora, Gerez Irvin
A307 The Effect of Korean Red Ginseng (KRG) on Rhinovirus Infection in Human Nasal Epithelial Cells
Joo Hyun Jung, Il Gyu Kang, Seon Tae Kim, Hyoungmin Park
A308 The Effect of Korean Red Ginseng on the Symptoms and Allergic Inflammation in Patients with Allergic Rhinitis
Seon Tae Kim, Joo Hyun Jung, Il Gyu Kang, Hyoungmin Park, Kwang-Pil Ko
A309 Validation of the Newly Developed Multiple Allergen Simultaneous Test in Korea
Jungsoo Lee, Howard Chu, Hemin Lee, Jung U Shin, Chang Ook Park, Kwang Hoon Lee, Kwang Hoon Lee, Hong Kyu Kang
A310 Assessment of Symptoms Severities of Allergic Rhinitis Patients Sensitive to Multiple Allergens in Skin Prick Test
Dong Chang Lee, Geun Jeon Kim, Jae Hyung Hwang, Jin Bu Ha, Su Hee Jeong
A311 Diurnal Temperature Range and Emergency Department Visits for Asthma in Korea 6 Cities
Ho Kim, Shinha Hwang, Whahee Lee
A312 Mannan-Binding Lectin Serum Levels in Atopic Mongolian Adults
Enkhbayar Bazarsad, Logii Narantsetseg, Munkhbayarlakh Sonomjamts
A313 Prevalence of Doctor Diagnosed Atopic Eczema, during 2003-2014 in KOREA ; Using Big Data of 48.1 Million South Korean Health-Care Records
Gwang-Cheon Jang, Hyun-Hee Lee, Chang-Jong Lee, Huynsun Lim
A314 Association of Recurrent Wheeze with Lung Function and Airway Inflammation in Preschool Children
Ji-Eun Soh, Dae-Jin Song, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
A315 Mannan-Binding Lectin Serum Levels in Healthy Mongolian Adults
Enkhbayar Bazarsad, Logii Narantsetseg, Munkhbayarlakh Sonomjamts
A316 Rotanebuliser
Prabhakarrao Pv, Ranjitha Nadendla
A317 The Level of Serum Interleukin 13 and Interleukin 17A and Its Effect Factors in Children with Asthma
Juan Fang, Jing Zhao
A318 Is Vitamin D Insufficiency Also Involved in Childhood Asthma in South Korea?
Dae-Jin Song, Sungchul Seo, Young Yoo, Yu-Ri Kim, Ji Tae Choung, Jee Hoo Lee
A319 Collection of Nasal Secretions for Measurement of Local IgE: A Quest for the Best Method
Margot Berings, Natalie De Ruyck, Claus Bachert, Philippe Gevaert, Gabriële Holtappels
A320 The Role of Claudin 5 in a Murine Model of Asthma
Pureun-Haneul Lee, Byeong-Gon Kim, Choon-Sik Park, George D Leikauf, An-Soo Jang
A321 Claudin-4 in a Murine Model of Asthma: Modulation By Acrolein, a Highly Reactive Unsaturated Aldehyde
Byeong-Gon Kim, Pureun-Haneul Lee, Choon-Sik Park, An-Soo Jang
A322 Efficacy and Safety of Sublingual Immunotherapy in House Dust Mite Sensitized Children with Allergic Rhinitis
Yang Park
A323 The Association of Vitamine D Deficiency and Skeletal Muscle Dysfunction in Chronic Airway Disease
Min-Su Sohn, Hyun Jung Jin, Dong-Won Lee, Jun-Hong Ahn, Jin Hong Chung
A324 Bacteria Derived Extracellular Vesicles in Indoor Dust Is Closely Associated with Airway Disease and Lung Cancer: Analysis of Indoor Dust’s Microbiome and IgG Sensitization of Indoor Bacteria Derived Extracellular Vesicles
Sae-in Kim, Han-Ki Park, Do-Yeon Kim, Mina Rho, Jun-Pyo Choi, Yoon-Keun Kim
A325 Clinical Care Program for Childhood Asthma (CCP-Childhood Asthma); A Multidisciplinary Team Care at Samitivej International Children’s Hospital
Wasu Kamchaisatian, Thitikul Hiranras, Surinda Wongpun, Phornthip Chiraphorn, Anupan Tantachun, Wannipa Wongrassamee, Planee Vatanasurkitt, Naratip Somboonkul, Nattipat Juthacharoenwong, Surangkana Techapaitoon, Montri Tuchinda
A326 Continuous B Cell Stimulation with CD40 Ligand Induce IgE Isotype Switching
Jae Ho Lee, Sejin An
A327 Effects of Interleukin-9 on Allergen-Specific Immunotherapy in a Mouse Model of Allergic Rhinitis
Ji-Hyeon Shin, Soo Whan Kim, Si Won Kim, Jun Myung Kang, Boo-Young Kim, Byung-Guk Kim
A328 Usefulness of Exhaled Nitric Oxide for Evaluating Wheeze and Airway Hyperresponsiveness in Preschool Children
Jung-Won Lee, Ji-Won Kwon, Woo Kyung Kim, Hyung Young Kim, Hyo-Bin Kim, Ju-Hee Seo, So-Yeon Lee, Gwang-Cheon Jang, Young-Ho Jung, Soo-Jong Hong, Byoung-Ju Kim, Dae-Jin Song, Jung Yeon Shim
A329 Systemic Cyclosporine Treatment in Hand Eczema Patients
Kyung Ho Kim
A330 Lipid Profiles and Adipokines in Korean Children with Atopic Dermatitis
Young Yoo, Won Suck Yoon, Sungchul Seo, In Soon Kang, Jae Won Choi, Hye-Young Lim, Ji Tae Choung
A331 Validation of Montelukast and Levocetirizine Combination Tablet Versus Individual Tablets in the Treatment of Moderate to Severe Persistent Allergic Rhinitis Among Adult Filipinos Seen at the Philippine General Hospital-Outpatient Department
Michelle Buela
A332 Efficacy of Makyokansekito on Treatment of Wheezing Lower Respiratory Tract Infection in Children: A Retrospective Study of 68 Patients
Koji Nishimura
A333 Serum Eosinophilia and Total IgE Are Associated with the Risk of Allergic Sensitization and Allergic Symptoms in Two Years Follow-up, Respectively
Sang Chul Park, Hyo Jin Chung, Chang-Hoon Kim, Ju Wan Kang, Seong-Chul Hong, Keun-Hwa Lee, Jaechun Lee, Hye-Sook Lee, Jeong Hong Kim
A334 The Sensitization to Russian Thistle on Mongolian Patients
Narantsetseg Logii
A335 The Association Between Air Pollution, Allergic Sensitization to Inhalant Allergens and Airway Hyperresponsiveness in Ulaanbaatar, Mongolia
Munkhbayarlakh Sonomjamts, Enkhbayar Bazarsad
A336 Pre-Coseasonal Treatment with a 5-Grass Pollen Sublingual Tablet in Adults Demonstrated a Reduction on Asthma Symptoms in Réunion Island
Bashir Omarjee
A337 Peak Expiratory Flow Rate Reference Values for Children Aged 5-14 Years Old in Beijing Urban Area
Shuo LI
A338 Soybean Storage Proteins As the Main Allergen in a Patient with Food-Dependent Exercise-Induced Anaphylaxis Due to Tofu
Miyuki Hayashi, Ruby Pawankar, Shingo Yamanishi, Toru Igarashi, Yasuhiko Itoh
A339 A Study of Allergy Skin Prick Test with Weed Pollen
Oyuntsatsral Batsaikhan, B. Gantulga, B. Enkhbayar, S. Munkhbayarlakh, L.Narantsetseg
A340 The Role of Neurotrophin in a Murine Model of House Dust Mite Induced Allergic Rhinitis
Pei-Chi Chen, Jiu-Yao Wang
A341 Mimotopes of the Major Shellfish Allergen Tropomyosin Suppress Splenocyte Proliferation and Local Cytokine Expression in a Mouse Model of Shellfish Allergy
Nicki Y. H. Leung, Christine Yee Yan Wai, Patrick S.C. Leung, Ka Hou Chu
A342 A Questionnaire Survey on Understanding of Atopic Dermatitis Among Korean Patients and Caregivers
Eun Jin Doh, Dong Hun Lee, Mira Choi, Hyun-Sun Yoon, Kyu Han Kim, Ji Soo Lim
A343 Comparison of the Dosage of Bronchodilators in the Bronchodilator Response Test in Children
Ji Hyeon Baek, Man Yong Han, Seung Jin Lee, Youhoon Jeon, Kyung Suk Lee, Young-Ho Jung, Hye Mi Jee, Youn Ho Shin
A344 The Expression and Effect of Natural Killer T Lymphocytes in Chidren with Asthma
Yi Jiang, Miao Liu
A345 Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital
Chaw Su Naing, Tze Chin Tan, Yong Yeow Chong
A346 Different Phenotypes of Bhr (bronchial hyperresponsiveness) By Natural Course in Children and It’s Characteristics
Young-Ho Kim, Eun Lee, Song-I Yang, Hyun-Ju Cho, Hyung Young Kim, Ji-Won Kwon, Young-Ho Jung, Byoung-Ju Kim, Ju-Hee Seo, Ho-Jang Kwon, Hyo-Bin Kim, So-Yeon Lee, Soo-Jong Hong, Soo Hyun Kim
A347 Spectrum of Allergens Causing Allergic Rhinitis and Asthma in Urban Bangalore, India − a Study of 120 Patients
Jacqueline Elizabeth Joseph, Soumya M. S, Ruby Pawankar, Harshitha Kumar
A348 High Prevalence of Wheezing Illness and Risk Factor of Atopic Asthma Progression in Korean Preschool Children
Sohyoung Yang, Sung-Il Woo
A349 Clinical and Laboratory Screening of Primary Immunodeficiency Diseases: International Effects
Nima Rezaei
A350 The Effect of Helicobacter Pylori Infection in Atopic Individuals
Sukran Kose, Basak Gol Serin, Arzu Didem Yalcin, Süheyla Serin Senger, Mehmet Erden, Ertan Serin
A351 Clinical Spectrum and Natural History of Chronic Urticaria in Hong Kong Children
Agnes Sze-Yin Leung, Ting Fan Leung
A352 Skin Prick Test Reactivity to Common Pollen Aeroallergens in Patients with Allergic Rhinitis − in Urban Bangalore, India
Harshitha Kumar, Soumya M.S., Jacqueline Elizabeth Joseph, Ruby Pawankar
A353 Seasonal Patterns of Asthma-Related ED Visits and Admissions in Children and Adolescents Who Visited Emergency Rooms of Korea in 2007-2012
Eun Hee Chung
A354 Prevalence of Atopic Dermatitis and Its Associated Risk Factors in Elementary School Children: A Cross-Sectional Study in Gyeonggi-Do, South Korea
Eunji Kim, Young Yoo, Ji Tae Choung, Sungchul Seo, In Soon Kang, Jue Seong Lee, Ji Hyen Hwang
A355 Intralymphatic Immunotherapy for Dermatophagoides Farinae, Dermatophagoides Pteronyssinus, Cat, and/or Dog Allergy in Patients with Allergic Rhinitis: 1 Year Follow-up
Sang Min Lee, Joo Hyun Jung, Seung Joon Choi, Eugene Joe, Hyunjung Hwang, Shin Myung Kang, Yu Jin Kim, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Sang Pyo Lee
A356 Respiratory Syncytial Virus Regulates IL-33 Expression in Bronchoalveolar Cells and Lung Tissue in Vivo
Alina Gaisina, Igor Shilovskiy, Aleksandra Nikonova, Oleg Kamyshnikov, Musa Khaitov, Alexander Mitin, Komogorova Viktoriya, Marina Litvina, Nina Sharova
A357 The Prevalence of Parent-Perceived Food Hypersensitivity in Pre-School Children Attending a Tertiary Care Hospital in Malaysia
Faizah Mohamed Jamli
A358 Th2 Dominant Airway Inflammation Induced By House Dust Mite Chitin Is Dependent on TNF-a and NKT Cell
Da-Il Yoon, Jun-Pyo Choi, Han-Byul Choi, Yoon-Keun Kim, Hyeon-Il Choi
A359 Geographic Variations in the Patterns of Sensitization to Aeroallergens in Korean Adults: A Multi-Center Study
Mingyu Kang, Mi Yeoung Kim, Sujeong Kim, Eun-Jung Jo, Seoung-Eun Lee, Woo-Jung Song, Sang Min Lee, Chansun Park, Yoon-Seok Chang, Jaechun Lee, Young-Koo Jee, Inseon S Choi, Kyung-up Min, Sang-Heon Cho
A360 Experimental Mouse Model of Asthma Induced By Dust Mite Dermatophagoides Pteronyssinus allergenic Extract
Anton Laskin, Oleg Kamyshnikov, Alexander Babakhin, Valentina Berzhets, Musa Khaitov
A361 Severe Refractory Pulmonary Complications in Children with Mycoplasma Pneumoniae Pneumonia
Sejin An, Jae Ho Lee
A362 Usefulness of Interactive e-Learning Education Program for Asthma Guideline
Sung-Yoon Kang, Yoon-Seok Chang, Kyung-up Min, Sang-Heon Cho, Sae-Hoon Kim, Yong Eun Kwon, Young-Koo Jee, Tae-Bum Kim, Hee-Bom Moon, Hye-Kyung Park
A363 Airway Inflammation Induced By House Dust Mite Derived Vesicles Is Mainly Induced By LPS Derived from Gram Negative Bacteria in Dust Mite.
Sang-Yoon Kim, Jun-Pyo Choi, Han-Ki Park, Ji-Hyun Lee, Yoon-Keun Kim
A364 Changes in the Recognition of Causal Allergen, Its Avoidance, and Allergen Specific Immunotherapy after Skin Prick Test / Intradermal Test, Nasal Provocation Test, and Intralymphatic Immunotherapy in Patients with Allergic Rhinitis: 1 Year Follow-up
Hyunjung Hwang, Eugene Joe, Sang Min Lee, Seung Joon Choi, Joo Hyun Jung, Yong Han Seon, Shin Myung Kang, Yu Jin Kim, Sun Young Kyung, Jeong-Woong Park, Sung Hwan Jeong, Sang Pyo Lee
A365 Laboratory Diagnostic of Staphylococcal Sensitization
Natalya Khramykhoverchenko
A366 Th-17 Regulatory Cytokines Enhance Neutrophil Production of IL-17 during Asthma
Saleh Al Muhsen, Asma Sultana, Rabih Halwani, Ahmed Bahammam
A367 Diagnostic Value of Serum Total IgE and Prediction of Cut-Off Value to Recommend Mast in Allergic Rhinitis
Hyung Chae Yang, Sun Kyung Kim, Kwang Il Nam
A368 Diagnostic Value of an Increase in FEV1 and/or FVC >12% and >200 mL from Baseline after Bronchodilators for Diagnosis of Asthma
Jeong-Eun Kim, Ju Suk Lee, Ji Hyun Lee, Kyung Woo Kang
A369 Combined Use of Fractional Exhaled Nitric Oxide and Bronchodilator Response in Predicting Future Loss of Asthma Control Among Children with Atopic Asthma
Je-Kyung Kim, Youn-Soo Hahn, Jae-Yub Jung
A370 Antigen-Specific IgA Plays an Important Role in Mucosal Immune Response in Allergic Children : Measurement of Secretory IgA and Antigen-Specific IgA
Yosuke Baba, Sususmu Yamazaki, Eisuke Inage, Mari Mori, Yoshikazu Ohtsuka, Masato Kantake, Toshiaki Shimizu, Asuka Honjoh, Tomoaki Yokokura
A371 Why Teaching Pediatrics Trainees about Anaphylaxis and Its Acute Management Is Essential: Cross Sectional Survey.
Mehdi Adeli, Shaza Ali Mohammed Elhassan, Caroline Beck
A372 Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children
Min Sun Na, Heysung Baek, Seung Jin Lee, Ji Hyeon Baek, Jungwon Yoon, Sun Hee Choi, Young-Ho Jung, Youn Ho Shin, Man Yong Han
A373 House Dust Mites Sublingual Immunotherapy Can Influence the Long-Term Evolution of Severe Atopic Dermatitis and the Progression to Respiratory Allergy.
Enrico Compalati, Maurizio Marogna
A374 The Positive Distribution Characteristics of 90 Food Specific IgG in Patients with Allergic Diseases
Huimin Huang, Baoqing Sun, Mingyu BAI, Yiting Huo, Peiyan Zheng, Nili Wei, Wenting Luo
A375 Evaluation of Serum Levels of Osteopontin As a Potential Biomarker of Immune Activation in Patients with Allergic Diseases
Elisa Villa, Anand Andiappan, Rosalba Minisini, Olaf Rötzschke, Elena Boggio, Luca Gigliotti, Nausicaa Clemente, Annalisa Chiocchetti, Umberto Dianzani, Mario Pirisi
A376 Prevalence of Allergic Rhinitis in 3-6-Year-Old (preschool) Children in Chiba City (urban area), Japan
Fumiya Yamaide, Syuji Yonekura, Naoki Shimojo, Yuzaburo Inoue, Yoshitaka Okamoto
A377 Comparative Efficacy of Combination Nebulized Salbutamol and Fluticasone Propionate and Nebulized Salbutamol in Children with Mild Moderate Asthma Attack
Retno Asih Setyoningrum, Landia Setiawati, Sri Sumei, Deddy Iskandar
A378 Characteristics of Children Hospitalized with Asthma in West Nusa Tenggara General Hospital Mataram Indonesia
Indriyani Sang Ayu Kompiyang
A379 Identification of Phenotypes in Allergic Bronchopulmonary Aspergillosis Using Cluster Analysis
Tsuyoshi Oguma, Jun Tanaka, Katsuyoshi Tomomatsu, Koichiro Asano
A380 The Roles of Type 2 Innate Lymphoid Cells (ILC2) in Chronic Rhinosinusitis (CRS)
Keisuke Uno, Yoshinori Matsuwaki, Kazuhiro Omura, Eika Hayashi, Norifumi Tatsumi, Hirohito Kita, Nobuyoshi Otori, Hiromi Kojima
A381 Respiratory Symptoms, Signs and Spirometry Indexes Comparision in 7-12 Years Old Girls in Esfahan Metropolis and Its Far Suburb
Mohammadreza Fatemi Khorasgani
A382 Induction of Kruppel-like Transcription Factor (KLF4&5) By Baker’s Yeast Mannan in Human Bronchial Epithelial and Smooth Muscle Cells
Dukhee/Betty Lew, Kim/S. Lemessurier, Joseph/a Moore, Jeoung-Eun Park, Ae-Kyung Yi, Chi/Young Song, Kafait/U Malik
A383 Korean Profile in Childhood Asthma Severity Classification
Dongin Suh, Ja Kyoung Kim, Hyeon-Jong Yang, Bong-Seong Kim, Youn Ho Shin, So-Yeon Lee, Geunhwa Park, Woo Kyung Kim, Hyo-Bin Kim, Heysung Baek, Dae Hyun Lim, Dae Hyun Lim, Jin Tack Kim
A384 Prevalence of Food Sensitization, IgE-Mediated and Non-IgE-Mediated Food Allergy Among Pediatric Patients Diagnosed with Autism Spectrum Disorders
Aimee Lou Manalo Nano
A385 Component-Resolved Diagnostic Study of Dermatophagoides Pteronyssinus Major Allergen Molecules in a Southern China
Wenting Luo, Baoqing Sun
A386 Risk Factors for Systemic and Local Reactions to Subcutaneous Allergen Immunotherapy
Hikmet Tekin Nacaroglu, Semiha Bahceci Erdem, Ozlem Sumer, Sait Karaman, Canan Sule Unsal Karkiner, Suna Asilsoy, Ilker Gunay, Demet Can
A387 Literature Review and Current Treatment Options for Cyclical Anaphylaxis
Danielle Kiers
A388 The Effect of Surfactant Protein D in Acute Lung Injury and Pulmonary Fibrosis Induced By Bleomycin
Hsu Han Yin, Jiu-Yao Wang
A389 Activation of Endothelial Cells to Release Hsp90, an Activator of the Prekallikrein-High Molecular Weight Kininogen (HK) Complex
Allen Kaplan, Kusumam Joseph, Baby G. Tholanikunnel
A390 The Effect of Climatic Treatment in 51 Asthmatic Children from Areas Severely Polluted Environment of Northern Moravia, Czech Republic
Radim Dudek
A391 Comparison of Some Vitamin Groups in Asthmatic Patients
Gulden Bilgin, Hatice Surer, Aytun Sadan Kilinc, Dogan Yucel
A392 Sensitization in Children with Atopic Dermatitis: A Single Center Study
Ji Young Lee, Jihyun Kim, Hea-Kyoung Yang, Minji Kim, Sang-Il Lee, Kangmo Ahn
A393 Staphylococcal Enterotoxin IgE Sensitization: A Risk Factor for COPD Overlap in the Elderly Asthma?
Sung Do Moon, Byung-Keun Kim, Sang-Heon Cho, Kyung-up Min, Yoon-Seok Chang, Heung Woo Park, Hye-Ryun Kang, Woo-Jung Song, Min-Koo Kang, Ju-Young Kim, Kyonghee Sohn, Ha Kyung Won, Seoung-Eun Lee, Kyung-Mook Kim, Claus Bachert
A394 The Effects of Probiotics and PparÎ3 on the Murine Model of Allergic Asthma
Miao-Hsi Hsieh, Jiu-Yao Wang
A395 Adult Patients’ Views on the Design of Adrenaline Autoinjectors
Helen Smith, Clare Brown, Christina Jones, Mark Davies
A396 CCL22 miRNA modulated Th1 responses and induced therapeutic effects on OVA-induced mouse model of asthma
Won Suck Yoon
A397 Clinical, Histological, and Skin Microbiome Characteristics of Head and Neck Dermatitis in Atopic Dermatitis
Hemin Lee, Howard Chu, Jungsoo Lee, Jung U Shin, Chang Ook Park, Kwang Hoon Lee, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim
A398 MicroRNA-432 modulates Th1 responses and induced therapeutic effects in atopic like murine model.
Won Suck Yoon
A399 Case Report of Near-Fatal Asthma Due to Snail Allergy in a House Dust Mite-Allergic Adult
Jean-Pierre L’huillier, Jean-Eric Autegarden, Catherine Bertrand, Dominique Tardy
A400 Relationship Between Gut Microbiota in the First 3 Months of Life and Infant Immune Function at Age 12 Months
Intan Hakimah Ismail, Mimi Tang, Paul Licciardi, Frances Oppedisano, Robert Boyle, Roy Robins-Browne
A401 A Pediatric Case of Food-Dependent Exercise-Induced Anaphylaxis Due to Spice Allergy
Hisako Yagi, Harumi Koyama, Yutaka Nishida, Takumi Takizawa, Hirokazu Arakawa
A402 Correlations Between Objective Severity Score and Each of the Subjective Severity Intensity in Atopic Dermatitis
Hong Kyu Kang, Hemin Lee, Jungsoo Lee, Jung U Shin, Kwang Hoon Lee, Kwang Hoon Lee, Howard Chu, Chang Ook Park
A403 Barrier Related Gene Mutations in Atopic Dermatitis
Na Young Yoon, Hyeyoung Lee, Seong Jun Seo, Eunhee Choi, Hye-Young Wang, Minyoung Jung, Eung Ho Choi, Dong Hye Kim
A404 Clinical Utility of Basophil Activation Test (BAT) in the Diagnosis of Drug Induced Anaphylaxis
Joo-Hee KimYoung-Sook Jang, Jeong-Hee Choi, Sunghoon Park, Young Il Hwang, Seung Hun Jang, Ki-Suck Jung
A405 Feeding Shapes the Colonization of Gut Microbiota and Associated with Total IgE in Infant
Mi-Jin KangDongin Suh, Eun Lee, Kil Yong Choi, Young-Ho Jung, Song-I Yang, Bong-Soo Kim, Ha-Jung Kim, Juneyoung Koh, Hyun-Jin Kim, Kangmo Ahn, Youn Ho Shin, Hyun-Ju Cho, Byoung-Ju Kim, Young-Ho Kim, Yean Jung
A406 CD8+T Cell-Intrinsic Smad4 Suppresses Th2 Responses in the Pathogenesis of Contact Hypersensitivity
Mizuko Mamura, Jeong-Hwan Yoon, Susumu Nakae, Inkyu Lee, Isao Matsumoto, Takayuki Sumida, Jin Soo Han, Katsuko Sudo, Ji Hyeon Ju
A407 Immune-Modulatory Genomic Properties Differentiate Gut Microbiotas of Infants with and without Eczema
Gaik Chin Yap, Wen Tso Liu, Seungdae Oh, Pei Ying Hong, Chiung Hui Huang, Marion Aw, Lynette Shek, Bee Wah Lee
A408 The Effect of Medication in OSA Patients with Allergic Rhinitis
Young Seok Byun, Sung Wan Kim, Tae Kyung Koh, Joong-Saeng Jo, Kun Hee Lee, Chul Kwon, Sung-Hwa Dong
A409 A Case of Generalized Pustular Psoriasis Mimicking Acute Generalized Exanthematous Pustulosis
Myung Shin Kim, Chansun Park
A410 Anaphylaxis Caused By Gummy Jelly Ingestion: A Case Report
Han Seok Cho, Min-Ju Kim, Min Ji Kim, Young Ok Park, Hye Yeong Lee, Hee Seong Kim, Eun Lee, Hyun-Ju Cho, Jinho Yu, Soo-Jong Hong, Keum Hee Hwang
A411 Serum Folliculin As a Novel Biomarker for Asthma
Jung-Hyun Kim, You Sook Cho, Sae-Hoon Kim, Hyouk-Soo Kwon, Mira Yoo, Hyo-Jung Kim, So-Young Park, Bomi Shin, So Young Park, Bomi Seo, Min-Gu Kim, Hee-Bom Moon, Jin-Ah Park, Tae-Bum Kim, Jaemoon Lee
A412 Corticosteroid Nasal Irrigations after Endoscopic Sinus Surgery in the Management of Chronic Rhinosinusitis with Asthma
Jin Hyeok Jeong, Tae Wook Kang, Han Seok Yoo, Yong Hee Cho, Seok Hyun Cho, Kyung Rae Kim
A413 Capsaicin Injection in Neonatal Period Potentiates Intensity and Duration of Atopic Dermatitis of Rats.
Jue Seong Lee, Sun-Ho Kee, Sewon Kim, Young Yoo, Heung Sik Na, Seung Keun Back
A414 Comparison Between the Impulse Oscillometry System, Spirometry, Feno, Lung Clearance Index and Asthma Control and Exacerbation Status.
Seung Jin Lee, Bo Seon Seo, Ji Hyeon Baek, Kyung Suk Lee, Young-Ho Jung, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Mi-Ae Kim
A415 The Association of Exhaled Nitric Oxide and Airway Hyperresponsiveness in Patients with and without Asthma
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A416 Effects of Air Pollution on Allergic Rhinitis in Korea
Jisun Park
A417 Exhaled Nitric Oxide in Korean Children with Allergic Rhinitis
Seung Hyun Moon
A418 A Questionnaire of Children with Asthma or Asthma and Allergic Rhinitis
Rong Jun Lin, Ren Zheng Guan
A419 A Case of Trimebutine-Induced Morbilliform Skin Eruption
Gyeong Yul Park, Hyun-Sun Yoon
A420 Comparison of Methacholine and Mannitol to Predict Exercise-Induced Bronchoconstriction in Children with Asthma
Woo-Hyeok Choi, Heysung Baek
A421 Different Inflammatory Mechanisms of Human Metapneumovirus and Respiratory Syncytial Virus
Jin-Sung Park, Eunmi Kwon, Zac Callaway, Chang-Keun Kim, Takao Fujisawa
A422 Sputum Microbiota in Chinese Adults with Eosinophilic Versus Non-Eosinophilic Asthma
Qingling Zhang, Rihuang Qiu, Naijian Li, Zhaowei Yang, Jing Li, Kian Fan Chung, Nanshan Zhong
A423 Which Clinical Features Are Useful in Predicting Presence of Staphylococcus Aureus colonization/Infection in Childhood Atopic Dermatitis?
Kam Lun E. Hon, Yin Ching K. Tsang, Ting Fan Leung
A424 Clinical Significance of Increased VEGF, TGF-Î21, and YKL-40, a Chitinase like Protein, in Serum of the Children with Asthma
Yoon Young Jang, Hai Lee Chung, Seung Gook Lee, Ji Hyun Na, Jong Hoon Lee
A425 Analysis of Follow-up Results of Mannitol Challenge Test in Asthma Patients
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A426 Analysis of 68 Oral Walnut Challenge Tests
Mikita Yamamoto, Sakura Sato, Noriyuki Yanagida, Ayako Ogawa, Kanako Ogura, Kyohei Takahashi, Kenichi Nagakura, Shigehito Emura, Tomoyuki Asaumi, Katsuhito Iikura, Motohiro Ebisawa, Yu Okada
A427 Effectiveness of Air Filters Intervention in Allergic Rhinitis
Jiaying Luo, Xiao Lan, Baoqing Sun, Zhao Chen, Guiyuan Sun, Shimin Li, Jiaqing Hu
A428 The Relationship Between Airway Hyperresponsiveness to Mannitol and Atopy in Asthmatic Children
Woo-Hyeok Choi, Heysung Baek
A429 Anaphylactoid Reactions to N-Acetylcysteine in the Treatment of Aacetaminophen Overdose
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A430 Effect of Prenatal Maternal Distress and GSDMB Polymorphism on the Development of Recurrent Wheezing in Early Childhood: COCOA Study
Yean Jung Choi, Si Hyeon Lee, Young-Ho Kim, Mi-Jin Kang, Hyun-Ju Cho, Eun Lee, Song-I Yang, Youn Ho Shin, Kangmo Ahn, Kyung Won Kim, Yoon Hee Kim, So-Yeon Lee, Hyoung Yoon Chang, In Ae Choi, Kyung-Sook Lee, Yee-Jin Shin
A431 Vitamin D Level in Allergic Rhinitis: A Systemic Review and Meta-Analysis
Yoon Hee Kim, Min Jung Kim, In Suk Sol, Seo Hee Yoon, Young a Park, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Yong Ju Lee
A432 Implication of Inspiratory and Expiratory Resistance and Reactance in Children with Asthma
In Suk Sol, Kyu-Earn Kim, Yoon Hee Kim, Min Jung Kim, Seo Hee Yoon, Yong Ju Lee, Kyung Won Kim, Young a Park, Myung Hyun Sohn
A433 The Association of Asthma Predictive Index with Asthma in Preschool Children with Recurrent Wheeze
Sung Joo Park, Ji-Won Kwon, Woo Kyung Kim, Hyung Young Kim, Hyo-Bin Kim, Ju-Hee Seo, So-Yeon Lee, Gwang-Cheon Jang, Young-Ho Jung, Soo-Jong Hong, Byoung-Ju Kim, Dae-Jin Song, Yun Seok Yang, Jung Yeon Shim
A434 Clinical Significance of Serum Total IgE Levels in Children with RSV-Associated Lower Respiratory Illness
Yoon Young Jang, Hai Lee Chung, Ji Hye Kim, Hyun Seok Lee, Chang Ho Lee
A435 Development of a Oak Pollen Emission and Transport Modeling Framework in South Korea
Changbum Cho, Yun-Kyu Lim, Kyu Rang Kim, Mijin Kim, Baek-Jo Kim
A436 Temperature, Humidity, and Air Pollution Affect Atopic Dermatitis Symptoms in Infants and Young Children
Young-Min Kim, Youngshin Han, Jihyun Kim, Hae-Kwan Cheong, Byoung-Hak Jeon, Kangmo Ahn
A437 Effects of Compound V on Pulmonary Fibrosis Model
Chuang/Yao Ming, Jiu-Yao Wang, Ye/Yi Ling
A438 Vitamin D Level and the Correlation with IgE in Children with Allergic Respiratory Diseases in Guangzhou China
Huimin Huang, Baoqing Sun, Yun Chen, Peiyan Zheng, Nili Wei, Wenting Luo
A439 Two Case Reports of Eosinophilic Gastroenteritis Associated with Allergic Disease
Do Hyeong Lee, Gil-Soon Choi, Hee-Kyoo Kim, Han Su Park
A440 Genome-Wide Association Study (GWAS) May Identify Common Genetic Variations Both in Immediate and Delayed Drug
So-Young Park, Hyo-Jung Kim, Bomi Seo, Jung-Hyun Kim, Min-Gu Kim, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim, Yoon Su Lee
A441 Development of a Questionnaire for Secular Change of Atopic Dermatitis from Birth to 19-Year-Old.
Akio Tanaka, Satoshi Morioke, Yukihiro Ohya, Naoki Shimojo, Akira Akasawa, Michihiro Hide, Hiroko Shizukawa
A442 Evaluation of the Adherence Starts with Knowledge-20 (ASK-20) to Inhaled Drug in Patients with Bronchial Asthma
Naoto Watanabe
A443 The Epidemiology and Clinical Manifestation of Hmpv Infection in Children during Recent 4 Years: 2011-2014
Meeyong Shin, Myeong Sun Jang
A444 Neutropenia Induced By Intravenous Immunoglobulin
Young-Hee Nam, Yeo Myeong Noh, Dong Sub Jeon, Hee-Joo Nam, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A445 A First Case of Lymphocytic Interstitial Pneumonitis in Healthy Child
Ji-in Jung, Ha-Su Kim, Hyun-a Kim, Jin-a Jung
A446 Cytokine Production upon House Dust Mite Stimulation of Cord Blood Mononuclear Cells from Caesarean Section-Delivered Singaporean Infants
Anne Goh, Rajeshwar Rao, Bindu Nandanan, Ruurd Van Elburg, Chua Mei Chien, Juandy Jo, Johan Garssen, Johan Garssen, Leon Knippels, Elena Sandalova, Wen Chin Chiang
A447 Dress Syndrome with Acute Interstitial Nephritis Caused By Quinolone and Nonsteroidal Anti-Inflammatory Drugs
Young-Hee Nam, Ji Young Juong, Soo Jin Kim, Eun Young Kim, Su Mi Lee, Young Ki Son, Hee-Joo Nam, Ki-Ho Kim, Soo-Keol Lee
A448 IL-23 Roles in the Development of House Dust Mite Allergic Sensitization and Asthma
Da-Eun Park, Hye-Ryun Kang, Heung Woo Park, Hyun Seung Lee, Yoon-Seok Chang, Jung-Won Park, Sang-Heon Cho, Kyung-up Min, Woo-Jung Song
A449 Exposure Profile of Indoor Risk Factors in Dwellings of Children with Atopic Dermatitis
Hyunwook Lim, Sungchul Seo, Ji Tae Choung, Young Yoo, Jun-Sik Park, Byung Kwan Kim
A450 Epidemiological Characterization of Blood Eosinophils in the Elderly Population
Ha Kyeong Won, Hye-Ryun Kang, Byung-Keun Kim, Sung Do Moon, Ju-Young Kim, So-Hee Lee, Woo-Jung Song, Heung Woo Park, Min-Koo Kang, Sun-Sin Kim, Sang-Heon Cho, Kyung-up Min, Yoon-Seok Chang, Kyoung Hee Sohn, Kyung-Mook Kim, Ki-Woong Kim, Hak Chul Jang
A451 Stevens-Johnson Syndrome Caused By Methotrexate in the Treatment of Psoriasis
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A452 Genetic Determinants for Lung Function Growth in Asthmatic Children
Ting Fan Leung, Man Fung Tang, Hing Yee Sy, Wa Cheong Chan, Wilson Wai San Tam
A453 The Power of Allergen Specific Ig E in the Classification of Rhinitis, Korean National Hanes 2010
Seung Kyu Chung, Sujin Kim, Sang Duk Hong, Hyo Yeol Kim Hyo Yeol Kim, Hun-Jong Dhong, Jong in Jeong
A454 Analysis of Allergen Immunotherapy Practice and Patients’ Knowledge and Attitude about Allergen Immunotherapy in a Single Tertiary Hospital in Korea
Young-Hee Nam, Dong Sub Jeon, Soo-Keol Lee
A455 Roles of Staphylococcal Enterotoxin B in House Dust Mite-Induced Acute Asthma Models
Ji Won Lee, Mingyu Kang, Soon-Hee Kim
A456 A Clinical Comparison of Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome in a Single Tertiary Hospital in Korea
Young-Hee Nam, Dong Sub Jeon, Hee-Joo Nam, Yeo Myeong Noh, Sang Hee Kim Kim, Ye Suel Park, Soo-Keol Lee
A457 The Beneficial Effect of Lactobacillus Gasseri PM-A0005 and Its Immunoregulatory Protein PMA5P40 on Milk-Induced Allergic Enteritis
Yung-I Hou, Jiu-Yao Wang
A458 Relationship Between Serum Folate Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children’s Environmental Health Study
Ja Hyeong Kim, Seol Jae Hee, Eun-Hee Ha, Hyesook Park, Mina Ha, Yun-Chul Hong, Yangho Kim, Namsoo Chang
A459 Effects of Vitamin D in Patients with Chronic Rhinosinusitis
Yuta Soma, So Watanabe, Ruby Pawankar, Ruby Pawankar, Harumi Suzaki, Harumi Suzaki, Hitome Kobayashi
A460 Clinical Features of Systemic Contact Dermatitis from Ingestion of Rhus
Young-Hee Nam, Chansun Park, Soo-Keol Lee
A461 Sublingual Immunotherapy Efficacy in Patients with Atopic Dermatitis in Korea
Jongrok Lee, Jooyoung Roh, Haryeong Ryu
A462 Characteristics of Serious Adverse Drug Reactions in a Tertiary University Hospital
Cheol-Woo Kim, Jae Hwa Cho, Mi Ra Eom, Ji Young Kang, Hye Gyeung Lee
A463 Eyelid Dermatitis: Patch Test Results during a 15-Year Period in Korea and Evaluation of Metal Contents in Eye Shadows
Hae Young Choi, Hye Jin Lee, Ju Yun Woo, Ji Yeon Byun, You Won Choi
A464 Relationship Between Lipid Levels and Risks of Allergic and Respiratory Diseases in Early Childhood: The Mothers and Children’s Environmental Health Study
Ja Hyeong Kim, Eun-Hee Ha, Hyesook Park, Mina Ha, Yun-Chul Hong, Yangho Kim, Namsoo Chang
A465 IL-32 in the Induced Sputum of Patients with Asthma
Jae-Woo Kwon, Hun Soo Chang, Jeong-Seok Heo, Jong-Uk Lee, Jong-Sook Park, Eusom Kim, Soo Hyun Kim, Choon-Sik Park
A466 Clinical Characteristics of Patients with Chromium Allergy in a Single University Hospital in Korea
Hae Young Choi, Ji Yeon Byun, Ju Yun Woo, You Won Choi
A467 Efficacy and Safety of Oral Acitretin in Chronic Hand Eczema
Hyun-Ju Jin, Jin-Hwa Son, Jeong-Min Kim, Gun-Wook Kim, Je-Ho Mun, Margaret Song, Hyun-Chang Ko, Moon-Bum Kim, Hoon-Soo Kim, Byung Soo Kim
A468 Atypical Antipsychotics and Anticholinergic Agents Mimicking Anaphylaxis
Sheryl Van Nunen, Dinh Van Nguyen, Anthony Elias, Susannah Olivia Lauer
A469 Introducing Reach (Reliable Estimation of Atopic dermatitis in ChildHood): Novel, Questionnaire-Based Diagnostic Criteria for Childhood Atopic Dermatitis
Seung-Chul Lee, Ho-June Lee, Jung Min Bae
A470 Comprehensive Assessment to Identify the Causative Factors in Oral Allergy Syndrome
Emi Ono
A471 Comparison of Interpretation Methods in Allergic Skin Test
Sung-Hwa Dong, Tae Kyung Koh, Young Seok Byun, Sung Wan Kim, Joong-Saeng Jo, Chul Kwon, Kun Hee Lee
A472 Refraining Aminophylline Use Increases Hospitalization Among Children with Acute Asthma: A 10-Years Retrospective Cohort Study
Li-Fan Liu
A473 The Prevalence and Risk Factors of Atopic Dermatitis from Nationwide Study for Korean School Students
Sunghee Lee
A474 Probiotic Recombination Protein Effect on Atopic Dermatitis
Wei-Leng Chen, Jiu-Yao Wang
A475 Allergic Sensitization Status in Various Inflammatory Skin Diseases
Youin Bae, Gyeong-Hun Park
A476 Two Cases of Good’s Syndrome: A Rare Acquired Immunodeficiency Associated with Thymoma
Suk Yeon Kim
A477 IL-23 Has a Role to Play in the Development of Asthma in Short-Term Cigarette Smoke Exposure-Induced House-Dust Mite Allergic Model
Hyun Seung Lee, Woo-Jung Song, Mingyu Kang, Han-Ki Park, Da-Eun Park, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Hye-Young Kim, Kyung-up Min, Sang-Heon Cho, Ji-Won Lee, Boram Bae, Jung-Won Park
A478 The Relationship Between the Relevance of Allergic Disease and the Value of Non-Specific IgE
Yasuhiro Suzuki
A479 Two Caces of Prawn Allergy in Adult Patients
Ismet Bulut, Zeynep Ferhan Ozseker
A480 Early Gut Bifidobacterium Breve and B. Catenulatum Colonisation Differentially Modulate Eczema Risk in Children at High-Risk of Developing Allergic Disease
Intan Hakimah Ismail, Robert Boyle, Paul Licciardi, Frances Oppedisano, Roy Robins-Browne, Mimi Tang
A481 Effects of Chronic Repeated Exposure of Staphylococcal Enterotoxin B on Allergic Asthma Model in Mice
Ji Won Lee, Hyun Seung Lee, Mingyu Kang, Da-Eun Park, Han-Ki Park, Soon-Hee Kim, Woo-Jung Song, Hye-Ryun Kang, Heung Woo Park, Yoon-Seok Chang, Chang-Han Park, Suk-Il Chang, Sook-Hee Song, Kyung-up Min, Sang-Heon Cho, Boram Bae
A482 Skin Prick Test Result and Allergen Immunotherapy in Children with Allergic Rhinitis
Grace Shieh
A483 Role of Brp-39 in RSV-Induced Airway Inflammation in Mice
Min Jung Kim, Jung Yeon Hong, Seo Hee Yoon, Doo Hee Shim, In Suk Sol, Yoon Hee Kim, Mi Na Kim, Kyung Eun Lee, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim, Jae Myun Lee
A484 Long-Term Outcomes of Twenty-Four Adults with Primary Immunodeficiency from a Single Centre in Singapore
Hiok Hee Chng
A485 Breast Feeding Increases the Risk of Food Sensitization but Does Not Affect Food Allergy in Young Children with Atopic Dermatitis
Dong Chan Kim, Song-I Yang, Hae Ran Lee, An Deok Seo, So Yeon Lee
A486 IgE Immunoadsorption Knocks Down Anaphylaxis.
Alessandro Fiocchi, Maria Cristina Artesani, Paola Francalanci, Lamia Dahdah, Thomas Schreiner
A487 Burden and Correlates of Cigarette Smoking and Respiratory Airway Obstruction: An Observation in Urban Adult Population of West Bengal (India)
Kaushik Chakraborty
A488 Blood Eosinophils Could Predict Sputum Eosinophilia? : A Comparison Between Asthma and Non-Asthmatic Chronic Cough in the Elderly
Ha Kyeong Won, Ju-Young Kim, Eun-Jung Jo, Kyoung Hee Sohn, Kyung-Mook Kim, Heung Woo Park, Yoon-Seok Chang, Sang-Heon Cho, Woo-Jung Song, Byung-Keun Kim
A489 Complementary and Alternative Medicine for Allergic Rhinitis in Japan
Syuji Yonekura, Yoshitaka Okamoto
A490 Impact of Cognitive Impairment on Asthma Control Status in Elderly Asthmatics
Gyu Young Hur, Young Min Ye, Joo-Hee Kim, Ki-Suck Jung, Junga Kim, Jae Jeong Shim, Hae-Sim Park
A491 The Association Between Respiratory Tract Infection and Reactive Oxygen Stress
Kazuhiro Sekimoto, Kazuko Sugai, Keiji Tsuchimoto, Hiromi Uehara, Masanori Ikeda
A492 The Risk Factors and Lung Function of Current Allergic Rhinitis Due to Dust Mite Sensitization
Euncho Chung, Kang Seo Park, Yean Jung Choi, Jeewon Park, Soo-Jong Hong, So Yeon Lee
A493 Cloning and Expression of Recombinant Blomia Tropicalis Dust Mite Allergen Blo t 7
Alain Jacquet, Arun Buaklin, Nat Malainual
A494 Seasonal Variations of Airborne Pollen in Bangalore, India
Roopashree S
A495 Pollen Observation and Use of Data
Kyu Rang Kim, Mijin Kim, Changbum Cho, Baek-Jo Kim, Jae-Won Oh, Mae Ja Han
A496 The Effect of Cord Serum 25-Hydroxyvitamin D (25(OH)D) on the Development of Atopic Dermatitis in First 3 Years of Life : Cocoa Study
Hyun-Ju Cho, Youn Ho Shin, Eun Lee, Young-Ho Kim, Darae Lee, Mi-Jin Kang, Song-I Yang, Kangmo Ahn, Kyung Won Kim, Yoon Hee Kim, Hye-Sung Won, Soo Hyun Kim, Suk-Joo Choi, Young Han Kim, Jong Kwan Jun, Eun-Jin Kim, Jeom Gyu Lee, So-Yeon Lee, Soo-Jong Hong, Dongin Suh
A497 Contribution of Stem Cell Factor Autocrine/Paracrine Mechanism to Aberrant Proliferation of Mast Cells
Yosuke Amagai, Akane Tanaka, Hiroshi Matsuda
A498 A Randomized Dbpc Dose-Finding Multicenter Trial of Sublingual Immunotherapy (SLIT) Allergoid Tablets in House Dust Mites (HDM) Allergic Patients
Ralph Mösges, Pauline Dieterich, Anatoli Astvatsatourov, Christoph Hüser, Jaswinder Singh, Kija Shah-Hosseini, Silke Allekotte, Enrico Compalati
A499 Depression and Allergy in the Elderly: A Community Population Analysis
Kyoung Hee Sohn, Woo-Jung Song, Byung-Keun Kim, Ju-Young Kim, Min Suk Yang, So-Hee Lee, Sae-Hoon Kim, Hye-Ryun Kang, Heung Woo Park, Sun-Sin Kim, Kyung-up Min, Sang-Heon Cho, Yoon-Seok Chang
A500 The Integrated Analysis of Correlation Between Total IgE and Other Immunological Factors in Allergic Diseases
Woo-Sung Chang, Ji-Hye Do, Yeon-Seop Kim, Dankyu Yoon, Hye-Sun Lim, Jeom-Kyu Lee, Eun-Jin Kim
A501 Pattern of Allergic Diseases Among Military Servicemen Referred to a Clinical Immunology/Allergy Service in Singapore
Bernard Thong, Yew Kuang Cheng, Jinfeng Hou, Khai Pang Leong, Justina Tan, Faith Chia, Grace Chan, Sze-Chin Tan, Teck Choon Tan, Chwee Ying Tang, Hiok Hee Chng
A502 A Case of Rifampicin-Induced Hypersensitivity Diagnosed By the Lymphocyte Activation Test with Successful Desensitization
Chan-Sun Park, Mi Yeoung Kim, Eun-Young Kim, Jae-Gook Shin, Jae-Hyeog Choi, Saegwang Park, Yeonye Kim
A503 Analysis of Individual Case Safety Reports of Drug-Induced Anaphylaxis Based on Korea Adverse Event Reporting System Database
Kyung-Hwan Lim, Jae Woo Jung, Mingyu Kang, Ju-Young Kim, Ju-Young Kim, Hyun Jeong Kim, Yeon-Ju Woo, Soo-Youn Jung, Hye-Ryun Kang, Hye-Ryun Kang
A504 Impact of Processes Certification on the Liability of Anti-Dust Mites Bed Covers
Thierry Porée, Nabile Boukhettala, Emeline Furon
A505 Localisation Kinetics of Aluminium after Subcutaneous Injection in a Rat Model
Alan David Bullimore, Matthew Heath, Simon Hewings, Murray Skinner
A506 Periostin Levels in Exhaled Breath Condensate of Competitive Athletes, Asthmatics and Healthy Subjects - Associations with Outdoor Ambient Conditions
Marcin Kurowski, Hubert Krysztofiak, Aleksandra Wardzynska, Marzanna Jarzebska, Janusz Jurczyk, Marek L. Kowalski
A507 The Role of PKR Pathway in Acute Exacerbation of Severe Bronchial Asthma
So Ri Kim, Yong Chul Lee, Dong Im Kim, Yang Keun Rhee, Heung Bum Lee, Seoung Ju Park, Yeong Hun Choe Choe, Seung Yong Park
A508 Diversity of Clinical Manifestations and Treatment Responses for Idiopathic Hypereosinophilic Syndrome
Joo-Hee Kim, Sunghoon Park, Young Il Hwang, Seung Hun Jang, Ki-Suck Jung
A509 Effect of Dexamethasone in Th17 Cell Mediating Neutrophilic Asthma
Nong Guang-Min, Jiang Min
A510 Allergen Profile for Asthma/Rhinitis and Eczema Among Patients in North India: An Immunocap Allergen Specific IgE Antibodies Assay Based Study
Nalin Nag
A511 Clinical Profile of Allergic Rhinitis in Children in Jakarta
Wahyuni Indawati
A512 Preclinical Study on the Use of Micro Crystalline Tyrosine (MCT) Adjuvants in Allergy Immunotherapy
Alan David Bullimore, Matthew Heath, Murray Skinner
A513 Genetic Diversity of Filaggrin Mutation and Its Clinical Implication in East Asian Atopic Dermatitis Patients
Seong Jun Seo, Won Jong Oh
A514 Protein and MPL Adsorption Capacities for MCT in Candidate Therapeutic Formulations for Use in Immunotherapy, Compared Against Existing Adjuvants
Alan David Bullimore, Murray Skinner, Matthew Heath, Andrew Bell
A515 Interleukin-22 Gene Variation in Inflammatory Bowel Disease
Alireza Zarebidoki, Hournaz Hasanzadeh, Salman Sadeghzade, Nima Rezaei
A516 Immunomodulatory Effects of Adipose-Derived Stem Cell Secretome in a Mouse Model of Asthma
Kyu-Sup Cho
A517 Diffuse Alveolar Hemorrhage with Positive Anti-Neutrophil Cytoplasmic Antibody in a Child : A Case Report
Sung-Woo Kim, Moo-Young Oh
A518 Clinical Analys the Serum TARC Levels As the Condition Index of Atopic Dermatitis in the Early Infancy
Munemitsu Koizumi, Kazuyo Kuzume
A519 An Analysis of the Filaggrin Gene Polymorphism in Korean Atopic Dermatitis Patients
Kui Young Park, Won Jong Oh
A520 A New Protocol for Wheat Oral Immunotherapy in Patients with Anaphylaxis
Delara Babaie, Mohammad Nabavi, Fariborz Zandieh, Mehrdad Amir Moini, Zahra Chavoshzadeh, Hamideh Seifi, Mitra Sahragard, Mehrnaz Mesdaghi, Mohammad Hassan Bemanian
A521 Clinical Characteristics of Filaggrin-Related Atopic Dermatitis Patients in Korea
Sun Young Choi, Yeon a No
A522 Early Allergy Diagnosis in Children - Self- Administered Questionnaire Vs Medical Verification
Andrzej M. Fal, Dorota Kiedik, Agnieszka Muszynska, Iwona Pirogowicz
A523 Asthma Impact on Children with Food Induced Anaphylaxis
Chikako Motomura, Masatoshi Wakatsuki, Yuko Akamine, Mihoko Iwata, Hiroshi Matsuzaki, Naohiko Taba, Yoko Murakami, Hiroshi Odajima
A524 Case Reports of Stevens-Johnson Syndrome and Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis in Systemic Lupus Erythematosus
Reni Ghrahani
A525 The Effectiveness of Oral Tolerance Induction for Wheat Allergy Using Two Different Intake Levels
Yuri Takaoka
A526 Association of Plasma Interleukin-25 Levels with Development of Aspirin Induced Airway Spasm in Asthma
Jong-Uk Lee, Jeong-Seok Heo, Da-Jeong Bae, Hyun Ji Song, Choon-Sik Park, Jong-Sook Park
A527 Transition of Allergic and Nonallergic Rhinitis after 2 Years in Korean Children: Preliminary Study
Jae Hoon Cho, Ji Ho Choi
A528 Early Onset of Psoriasis Juvenile Idiopathic Arthritis
Budi Setiabudiawan, Fiska Febriana, Reni Ghrahani, Gartika Sapartini
A529 Clinical Features of Immediate Hypersensitivity to Histamine H2 Antagonists and Their Cross Reactivity
Chan-Sun Park, Young-Hee Nam, Mi Yeoung Kim, Gil-Soon Choi
A530 Detection of Galacto-Oligosaccharide Specific IgE in Vitro
Chiung-Hui Huang, Chiung-Hui Huang, Jian Yi Soh, Lynette Shek, Lynette Shek, Dianne J. Delsing, Bee Wah Lee, Bee Wah Lee, Si Hui Goh, Wen Chin Chiang, Wenyin Loh
A531 The Association Between Serum Vitamin D Levels and Allergic Diseases in Elementary Schoolchildren
Hea-Kyoung Yang, Ji Young Lee, Minji Kim, Kangmo Ahn, Jihyun Kim, Young-Min Kim, Hye-Young Kim, Yong Mean Park, Woo Kyung KIM, So-Yeon Lee
A532 Serum Levels Specific IgE to Toxic Shock Syndrome Toxin Type 1 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyp in Korean
Jongin Jeong, Sang Duk Hong, Seung Kyu Chung, Hun-Jong Dhong, Hyo Yeol Kim Hyo Yeol Kim, Sujin KIM
A533 Impacts of Rhizosphere Cleaning Effects of Potted Indoor Plants on the Symptoms and Stress of Students with Allergic Rhinitis in Newly Built Schools
Yong-Won Lee, Hana Bak, Hye-Rim Son, Si-Eun Lee, Kwang-Jin Kim, Young-Wook Lim, Ho-Hyun Kim
A534 A Case of Multiple Food Allergies with Recurrent Anaphylaxis Successively Controlled By Omalizumab
Mi-Ae Kim, Man Yong Han, Young-Ho Jung, Hye Mi Jee, Seung Jin Lee, Kyung Suk Lee
A535 Bepotastine-Induced Urticaria, Cross-Reactive with Other Antihistamines
Jasmina Golez, Jaechun Lee, Eunkyoung Lee
A536 Role of SLC26a4 in Ozone - Induced Airway Reactivity and Inflammation
Da-Jeong Bae, Chang-Gi Min, Jong-Uk Lee, Jong-Sook Park, Hun Soo Chang, Choon-Sik Park, An-Soo Jang
A537 PAR2-Antagonist Suppresses Protease-Induced Allergic Inflammation Mediated By Degradation of Lung Epithelial Tight Junction and Generation of ROS
Young-Joon Kim, Bok Kyoung Jung, Seung-Hwa Lee, Mi-Jin Kang, Sekyoo Jeong, Eun Lee, Hyun-Ju Cho, Young-Ho Kim, Song-I Yang, Seo Hee Kim, Soo-Jong Hong
A538 Novel Anti-IL-4Ra Nanocarrier Approach for the Efficient Control of Lung Tissue Inflammation during Asthma
Rabih Halwani, Saleh Al Muhsen, Asma Sultana, Achraf Al-Faraj, Rosan Kanana, Sibtain Afzal, Roaa Al Kufaidi
A539 Clinical Factors for Improved Allergen Reactivities Induced By Subcutaneous Allergen Specific Immunotherapy with House Dust Mites during 1 Year Period
Hee-Kyoo Kim, Chul-Ho Oak, Gil-Soon Choi, Ye-Jin Moon, Eun-Kee Park
A540 Cytokine Gene Polymorphisms in Iranian Patients with Kidney Acute Rejection
Alireza Zarebidoki, Mina Abrari, Ali Akbar Amirzargar
A541 Phthalate Exposure and Obesity in Atopic Dermatitis of Korean Children and Adolescents
Ju-Hee Seo, Mina Ha, Soo-Jong Hong
A542 Which Drives Chronicity of Cough in Adults: Based on the Knhanes 2010-2012
Mingyu Kang, Byung-Ha Cho, Han-Ki Park, Han-Ki Park, Kyung-Mook Kim, Chang-Han Park, Heung Woo Park, Heung Woo Park, Yoon-Seok Chang, Yoon-Seok Chang, Yoon-Seok Chang, Sook-Hee Song, Mi-Kyeong Kim, Mi-Kyeong Kim, Sang-Heon Cho, Suk-Il Chang, Kyung-up Min, Kyung-up Min, Alyn Morice
A543 Elevated Airway CD45RO Memory Cells in Wheezing Children with Lower Respiratory Infection
Jungi Choi, Yusok Han, Jin-Sung Park, Eunmi Kwon, Chang-Keun Kim
A544 Quality of Life in Obese Children with or without Atopic Disease
Gartika Sapartini
A545 Relation of Human microRNA in Sputum of Asthma with Influenza A Virus Infection-Induced Exacerbation
Ji-Na Kim, Seungwoo Shin, Hun Soo Chang, Eun-Young Shim, Ji Ah Jun, Hyeonju Lee, Jong-Sook Park, Choon-Sik Park
A546 Aeropolinologic Monitoring and Distribution of Allergoallergens in Western Georgia
Revaz Sepiashvili, Darejan Khachapuridze, Sofio Gamkrelidze, Manana Chikhladze
A547 Extracorporeal Membrane Oxygenation As Emergency Treatment for Patients with Near-Fatal Status Asthmaticus
Seung-Eun Lee, Yun-Seong Kim, Doo-Soo Jeon, Woo-Hyun Cho, Hye-Ju Yeo, Seong-Hoon Yoon, Seung-Hyun Kim
A548 Relationship of S100calcium Binding Protein A9 with Neutophilic Inflammation in Murine Asthma Model
Taehyeong Lee, Hyun Ji Song, Choon-Sik Park, Ji Ah Jun, Jong-Sook Park
A549 Whole-Exome Sequencing of Aatopic Dermatitis in Korean Childhood
Dankyu Yoon, Yeon-Seop Kim, Woo-Sung Chang, Mi-Jin Kang, Soo-Jong Hong, Jeom-Kyu Lee, Eun-Jin Kim
A550 A Case of Generalized Molluscum Contagiosum in an Adult Patient with Severe Atopic Dermatitis
Minkee Park
A551 Discovery of Putative Macadamia Nut Allergens By Patient IgE Binding and a Label-Free Shotgun Proteomics Approach
Nanju Alice Lee, Johanna Rost, Sridevi Muralidharan, Dianne Campbell, Sam Mehr
A552 Anti-FcÎμri Antibody Inhibits Allergic March in Mice By Suppressing Th17 Pathway Via Suppression of FcÎμri-Mediated Mast Cells Activation
Seung-Hwa Lee, Seon-Joo Yoon, Ha-Jung Kim, Eun Lee, Song-I Yang, Young-Ho Jung, Ho-Sung Yu, Hee-Suk Kim, Yeon Hee Park, So-Yeon Lee, Jun-Sung Park
A553 Clinical Characteristics and the Associated Factors of ATG Hypersensitivity Reaction
Ha Kyeong Won, Min-Koo Kang, Sung Do Moon, Byung-Keun Kim, Ju-Young Kim, Sang-Heon Cho, Hye-Ryun Kang, Ji-Su Shim, Soo Jie Chung
A554 Reference Value and Utility of Total Serum Immunoglobulin E in Korean Schoolchildren
Jaehee Choi, Kangmo Ahn, Kwanghoon Kim, Jihyun Kim, Jiyoung Lee
A555 Two-Step Prescreening Skin Testing May be Useful for Reducing Immediate Hypersensitivity Reaction to Nonionic Contrast Media: Results of 7-Year Period in a Secondary Hospital
Bo Bae Park, In Young Nho, Chang-Han Park, Jang Min Kim, Suk-Il Chang
A556 Prevalence of Allergic Sensitization in Patients with Allergy Rhinitis; Gwangju, Jeonnam State Study
Sun Kyung Kim, Hyung Chae Yang, Kwang Il Nam
A557 Analysis of IgE Binding Components of Walnut in Korean Children Effect of Cooking Methods on the Allergenicity of Walnut Proteins
Jeongmin Lee, Jeongmin Lee, Sooyoung Lee, Kyunguk Jeong, Se-Ah Jeon
A558 Assessment of Autonomic Nervous Function in Subjects with Cholinergic Urticaria Associated with Acquired Idiopathic Generalized Anhidrosis
Midori Fujiwara, Shoko Shindo, Hiroyuki Murota, Mayuko Tahara, Aya Takahashi, Ichiro Katayama
A559 Interleukin 1 Beta in Sputum of Patients with Asthma: Relation with Airway Obstruction and Neutrophilc Inflammation
Jae Woo Jung, Hyun Ji Song, Taehyeong Lee, An-Soo Jang, Jong-Sook Park, Hun Soo Chang, Choon-Sik Park, Byoung Whui Choi
A560 Interleukin 8 in Sputum of Patients with Asthma: Relation with Neutrophilc Inflammation and Exacerbation
Min-Hye Kim, Da-Jeong Bae, Hyun Ji Song, Taehyeong Lee, Ji Ah Jun, Jong-Sook Park, An-Soo Jang, Hun Soo Chang, Young Joo Cho, Choon-Sik Park
A561 Prostaglandin E2 and Transforming Growth Factor-Î2 Play a Critical Role in Suppression of Allergic Airway Inflammation By Adipose-Derived Stem Cells
Sue Jean Mun
A562 Inhalation of Fine Particles Kill Alveolar Macrophages to Release IL-1alpha That Promote Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Formation
Etsushi Kuroda, Koji Ozasa, Ken Ishii
A563 Association Between Smoking and Allergic Diseases in the Korean Adult General Population
Sunmi Kim, Gyeong-Hun Park
A564 Relationship of S100 Calcium Binding Protein A9 with Inflammasome Activation in Murine Asthma Model
Hyun Ji Song, Taehyeong Lee, Ji Ah Jun, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
A565 Cluster Analysis of Asthma Phenotypes to Predict Exacerbation in Korean Population
Mi-Ae Kim, Seungwoo Shin, Jong-Sook Park, Hun Soo Chang, You Sook Cho, Hae-Sim Park, Choon-Sik Park
A566 Effect of AG490 on the Expression of TH17 CELLS and Tregs in the MOUSE MODEL of Neutrophilic Asthma
Zhang Min
A567 Association Between the Clinical Characteristics and Disease Severity in Hospitalized Bronchiolitis Patients Younger Than Two Years Old
Seo Hee Yoon, In Suk Sol, Young a Park, Yoon Hee Kim, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim
A568 Comparison Between House Dust Mite and Aspergillosis Sensitization in Patients with High Level of Tige
Wu Shiquan
A569 The Prevalence of Metal Allergy in the Patients with Orthodontic Appliance
Yongwon Lee, Hana Bak
A570 Component Resolved Diagnosis and Single Nucleotide Polymorphism Analyses: Towards the Development of Specific Immunotherapy for Allergy
Maricar Wisco Ching, John Donnie Ramos
A571 Clinical Features of Anaphylaxis Caused By Peanut, Tree Nuts and Seeds in Children and Adolescents: Multi-Center Study with 126 Patients
Kyunguk Jeong, Sooyoung Lee, Kangmo Ahn, Myung Hyun Sohn, Kyung Won Kim, So-Yeon Lee, Tae Won Song, Youhoon Jeon, Jihyun Kim, Taek Ki Min, Kyu-Earn Kim, Bok-Yang Pyun, Hyeon-Jong Yang, Hae Ran Lee, Youngmin Ahn, Ji-Won Kwon, Dae Hyun Lim, Jeong Hee Kim, Dongin Suh, Hyung Young Ki
A572 A Report of Two Cases of Anaphylaxis Caused By Perilla Seed in Children
Kyunguk Jeong, Byeong Sub Park, Sooyoung Lee, Se-Ah Jeon, Kyu Jung Park
A573 Prenatal Fine Particulate Matter Affects Wheezing in Children with TLR4 Polymorphism: Cocoa Study
Song-I Yang, Eun Lee, Hyun-Ju Cho, Young-Ho Kim, Mi-Jin Kang, Yean Jung Choi, Kil Yong Choi, Youn Ho Shin, Kangmo Ahn, Kyung Won Kim, Byoung-Ju Kim, So-Yeon Lee, Eun-Jin K
A574 Intensified B Lymphocyte Depletion (IBLD) without Immunosuppressive Maintenance Treatment As a Rescue Therapy in Refractory Lupus Nephritis (LN): a 4-Year Observation.
Roccatello Dario
A575 Relationship Between Th17 Cells and Neutrophilic Airway Inflammation in Childhood Neutrophilic Asthma
Jing Liao
A576 Clinical Applications of Impulse Oscillometry in Asthma Management after Exacerbation in Preschool Children
Yong Feng, Yunxiao Shang
A577 Contact Allergy to Sodium Sulfite and Its Relationship to Facial Cosmetic Contact Dermatitis
Yongwon Lee, Hana Bak
A578 Effect of Exposure to Air Pollution on Asthma and Lung Function Development
Hyung Young Kim, Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Eun Lee, So-Yeon Lee, Song-I Yang, Young-Ho Jung, Hyo-Bin Kim, Ho-Jang Kwon, Hee Ju Park
A579 Role and Relational Mechanism of AG490 in Airwayinflammation in the Mouse Model of Neutrophilic Asthma
Zhang Min, Nong Guang-Min, Jiang Min
A580 Incidence of Adverse Reaction to Radioconstrast Media in a Single Tertiary Hospital
Gyu Young Hur, Eun Jung Sim, Sora Yoon, Juwhan Choi, Junga Kim, Jae Keom Sim, Jee Youn Oh
A581 Cow’s Milk Oral Food Challenge: Clinical and Laboratory Features in Korean Children
Kyunguk Jeong, Byeong Sub Park, Jeong-Min Lee, Sooyoung Lee, Eunjae Cheon, Youngjoo Na, Kyu Jung Park, Eunjoo Lee
A582 Validation of the Red Maple Trials Allergen Challenge Theatre for Ragweed Pollen Challenge
William Yang, Suzanne Kelly, Rob Perrins, Jimmy Yang
A583 Preliminary Evaluation of the Red Maple Trials Allergen Challenge Theatre for Grass Pollen
William Yang, Suzanne Kelly, Rob Perrins, Jacob Karsh, Jimmy Yang
A584 The Association Between Tobacco and the Risk of Asthma in Urban and Rural Children in San Francisco, Argentina
Hector Badellino, Alvaro Teijeiro, Mabel Cuello, Marilyn Urrutia Pereira, Gustavo Egues
A585 The Prevalence of Allergic Rhinitis in University Students in Manisa
Ayse Aktas
A586 Allergen Sensitization in Zimbabwean Children with Atopic Dermatitis
Jin-Kyong Chun, Hilda Angela Mujuru, Elopy N Sibanda
A587 Vitamin D Insufficiency in Asthmatic Patients
Andreea Ioana Popescu, Raluca Greblescu
A588 The Prevalence of Hypersensitivity Reactions Against Drugs Among University Students.
Suheyla Rahman, Ayse Aktas
A589 Sublingual Immunotherapy Among Problematic Patients, Suffering from Allergic Rhinitis.
Nataly Tataurshchikova
A590 A Novel Biomarker for Wheezing and Atopy in Early Infancy
Eishika Dissanayake, Yuzaburo Inoue, Naoki Shimojo, Taiji Nakano
A591 Prognostic Factors for Atopic Dermatitis in Spontaneously Born Babies from Low Socioeconomic Background
Conny Tanjung
A592 Higher IgE Antibody Levels Mediate Anti-Cancer Immunity in Transgenic KN1 Hyper-IgE Mice
Erika Jensen-Jarolim, Judit Fazekas, Josef Singer, Anna Lukschal, Reinhard Horvat, Gertrude Achatz-Straussberger, Gernot Achatz
A593 Fructooligosaccharides Intake during Pregnancy and Lactation Increases Gut Bifidobacterium and IL-27 in Breast Milk
Yuji Fujita, Shuji Ikegami, Yoshitaka Nakamura, Yuzaburo Inoue, Naoki Shimojo, Yoichi Kohno, Shuichi Suzuki, Naoko Ozawa, Takayuki Kubota, Ken Nonaka, Osamu Ohara, Kentaro Masuda
A594 Effect of Nintedanib on Asthma in Mouse Model
Chin Kook Rhee, Sook Young Lee, Hwa Young Lee, Hea Yon Lee, Ji Young Kang, Sei Won Kim, Soon Seog Kwon, Young Kyoon Kim
A595 Delayed Contrast Media Hypersensitivity after Coronary Angiography
Gun-Woo Kim, Ju-Young Kim, Sang-Heon Cho, Hye-Ryun Kang, Hyo-Soo Kim, Jung Gyu Han, Jin Lee, Ji Young Lee, Ji Young Go, So Jung Park
A596 Gene Expression Profiling in Patients with Chronic Idiopathic Urticaria Reveals Unique Gene Signature Distinct from Healthy Controls
Julie Kim-Chang, Cassandra Love, Patricia Lugar
A597 Failure to Recognize Lymphopenia in Newborn Leads to Undetectable Primary Immunodeficiency
Endah Citraresmi
A598 The Concordance Between Lung Function Test and Indonesian Version of Childhood Asthma Control Test (CACT)
Nastiti Kaswandani, Cynthia Utami, Mardjanis Said
A599 Synergistic Interaction Between Bronchiolitis and PM10 Is Modified By IL-13 Polymorphism on Asthma Development: Replication from Cheer Study
Young-Ho Jung, Song-I Yang, Byoung-Ju Kim, Ji-Won Kwon, Hwan-Cheol Kim, Jong-Han Leem, Ju-Hee Seo, Hyung Young Kim, So-Yeon Lee, Ho-Jang Kwon, Hyo-Bin Kim, Hyun-Ju Cho
A600 The Transcription Factor Ehf Is Involved in TGF-b-Induced Suppression of Fceri and c-Kit Expression and Fceri-Mediated Activation in Mast Cells
Susumu Yamazaki, Nobuhiro Nakano, Asuka Honjoh, Eisuke Inage, Yosuke Baba, Yoshikazu Ohtsuka, Toshiaki Shimizu
A601 The Follow up of the Potential Immunosuppressant Effects of Marijuana (MJA)
Ishaq M, Sameera MI Khan, Imran Khan, Sabeen Khan
A602 Risk Factors of Allergen Sensitization at 3 Years: Results from the Gusto Study
Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Yap Seng Chong, Bee Wah Lee, Lynette Shek, Alison Joanne Lee
A603 IL-6 Blockade As a Steroid-Sparing Treatment for Rhupus Patients
Daniela Rossi
A604 Examination of Late Pulmonary Toxicity in Children Treated for Malignancies
Agnes Nemeth
A605 Technical Validation of the Repurposing of a Personal Particle Sampler to Determine House Dust Mite Exposure in the Ambient Air
Torsten Sehlinger, Karl-Christian Bergmann, Frank Goergen
A606 Zinc Deficiency in Children with Severe Atopic Dermatitis: More Common Than Generally Thought
Mohammad S. Ehlayel, Abdul Bari Bener
A607 Strong Association Between HLA-B*5801 Allele and Allopurinol – Induced Severe Cutaneous Adverse Reactions in Vietnamese
Hieu Chi Chu, Nga Thi Quynh Do, Dinh Van Nguyen, Ha Thi Thu Nguyen, Huong Thi Minh Le, Sheryl Van Nunen, Christopher Vidal, Suran Fernando
A608 Successful Rapid Desensitization to Glatiramer Acetate: Report of 2 Cases
Fotis Psarros, Ekaterini Syrigou, Ekaterini Politi, Spyridon Chrysoulakis
A609 Asthma Exacerbations Seasonal Variation in Two Perennial Phenotypes during Twenty Years (1995-2014): House Dust Mite Monosensitized and Non Atopic Patients
Dimitrios Vourdas, Konstantinos Petalas
A610 Occupational Allergy to Fungal Spores Among the Farmers of Paddy Fields in West Bengal, India: An Aeromycological and Immunological Approach
Mouli SAHA, Kashinath Bhattacharya
A611 Study of Efficacy of Sublingual Immunotherapy (SLIT) in Cases of Severe Persistent Allergic Rhinitis
Subir Jain
A612 Mesenchymal Stem Cells Suppress Lung Inflammation and Airway Remodeling in Chronic Asthma Rat Model Via PI3K/Akt Signaling Pathway Mesenchymal Stem Cells Suppress Lung Inflammation and Airway Remodeling in Chronic Asthma Rat Model Via PI3K/Akt Signaling
Xiaolian Song, Haiyan Lin
A613 Development of Allergen ELISA Kits for Dust Mites, Pollen, and Pet Dander
Kyohei Nishikawa, Takashi Shimada, Hiroshi Yasueda, Tadao Enomoto, Daisuke Aizawa, Takayoshi Kobayashi
A614 Yoga As a Lifestyle Modification to Improve the Quality of Life in Smokers with Allergic Rhinitis
Chellaa R
A615 Study of Incidence of Severe Persistent Allergic Rhinitis in Different Age Groups,Sex Prevalance and Type of Allergen” Aeroallergen or Food Allergen” Responsible for Severe Persistent Allergic Rhinitis in Central India
Subir Jain
A616 Causative Allergens in Cases of Severe Persistent Allergic Rhinitis in Central India
Subir Jain
A617 Atopic Dermatitis: A New Data on the Mechanisms of Chronic Pruritus
Marina Yudina
A618 The Efficacy and Safety of Peanut Oral Immunotherapy in High-Dose with Predicting Factors
Ishaq M, Sameera MI Khan, Imran Khan, Sabeen Khan
A619 Evaluation of Long-Term Prognosis and Topical Corticosteroid Usage after One Year of Proactive Treatment for Children with Moderate-to-Severe Atopic Dermatitis
Mayako Saito
A620 Allergy Symptoms in the First Two Months of Life
Nurul Iman Nilam Sari
A621 Factors Related to the Seasonal Variation of Allergic Rhinitis
Jae Young Kim, Jaechul Song, Inah Kim, Kyeong Joon Lee, Soo Jin Park, Soo Yong Roh
A622 Allergic Risk Survey in Lao Children at out-Patient Department, Children’s Hospital, Vientiane Capital, Lao PDR
Somxay Billamay
A623 Correlation Between Food Allergy, Aeroinhalant Allergy, Allergic Rhinitis, Atopic Dermatitis, and Acute Upper Respiratory Tract Infections and Levels of Severity of Asthma in Pediatric Medicine Department Saiful Anwar Hospital Indonesia
Muchammad Fahrul Udin
A624 Comparative Study of Pine, Oak, and Ginkgo Pollen Counts in Korea during Last Four Years
Mae Ja Han, Jae-Won Oh, Kyu Rang Kim, Baek-Jo Kim
A625 Effectiveness of Allergy-Test Directed Elimination Diets in Eosinophilic Esophagitis
Jorge A Mazza, Jason Kangeun Ko, David JT Huang
A626 Comparison of Cut-Off Values and Probability Curves for Egg Specific IgE in Diagnosis of Egg Allergy in Young Children
Kanae Furuya, Keigo Kainuma, Takahiro Ito, Mizuho Nagao, Takao Fujisawa, Junya Hirayama, Yu Kuwahara
A627 A Case of Persistent Atopic Dermatitis Associated with Parasitic Infection
Rosanna Qualizza, Cristoforo Incorvaia, Anna Maraschini
A628 Aeroallergenic Profile of Indoor Allergens and Their Clinical Relevance in Allergy and Asthma Patients in Saudi Arabia
Syed Mohammed Hasnain, Abdulrahman Al-Frayh
A629 Oral Exposure to the Amino Acid Glycine Inhibits the Onset of Allergic Disorders
Anita Hartog, Jacqueline Bastiaans, Reinilde Loonstra, Lieke Rutten, Lucien Harthoorn, Jeroen Van Bergenhenegouwen, Johan Garssen, Johan Garssen
A630 Cough As a Key Symptom in Asthma, Allergic Rhinitis, COPD and Rhinosinusitis and Its Impact in Korea
Kwang-Ha Yoo, Sang-Heon Cho, AG Ghoshal, Abdul Razak Bin Abdul Muttalif, Horng- Chyuan Lin, Sanguansak Thanaviratananich, Shalini Bagga, Rab Faruqi, Santwona Baidya, Colman Taylor, De Yun Wang, Hae-Ryun Ahn, Soon-Kwan Hong, Jong-Woong Kim, Gui-Hyun Nam, Mee-Ja Kim, Jae-Kyoung Park
A631 Cysteine Protease Allergen Def f 1 Induces Th2 Cytokines in Mouse Bone Marrow Derived Basophils Via ERK and JNK Dependent Pathways
Myung-Hee Yi, Kyoung Yong Jeong, Ju-Yeong Kim, Tai-Soon Yong
A632 Novel Multiple Allergy Testing Kit Using Parallel Lines Array (PLA) Technology
Bum Joon Kim, Hs Joo, Kj Lim, Jae-Hyun Lee, Jung-Won Park, Kh Yoon, DS Choi
A633 Quantitative Rapid Kit for Human Immunoglobulin
Hanseung Joo, Bum Joon Kim, Kj Lim, MJ KIM, DS Choi, Kh Yoon
A634 Total IgE Measurement By Protia Allergy-Q: Comparison Study with Immunocap
Bum Joon Kim, Hanseung Joo, Woo Sang Jung, Kj Lim, DS Choi
A635 Prevalence and Risk Factors of Asthma Among Korean Farmers
Ji-Hoon Lee, Soon-Chan Kwon, Soo-Jin Lee, Soo Yong Roh, Hogil Kim, Kyeong Joon Lee
A636 Dietary Intake and Perceived Immune Status in Young Dutch Women
Aurora Van De Loo, Amanda Fernstrand, Johan Garssen, Joris Verster
A637 The Effects of Antihistamine Drugs on on-Road Driving Performance
Aurora Van De Loo, Johan Garssen, Joris Verster
A638 Grass Is Guilty: A Case of Anaphylactic Shock and Asthmatic Status in the Same Time in an Individual
Jasmina Golez
A639 Cyclic Gamp-AMP(cGAMP) Induces Allergic Inflammation
Koji Ozasa, Etsushi Kuroda, Ken Ishii, Ken Ishii
A640 Role of Omalizumab in the Setting of Recalcitrate Dermatitis with Extremely Elevated IgE Levels
Muhammad Imran, Selina Gierer, John Martinez
A641 Follow-up Study on the Natural History of Prawn Allergy
Lydia Wong, Bee Wah Lee, Gaik Chin Yap, Genevieve Llanora, Bernard Thong, Lynette Shek
A642 Protein-Losing Dermopathy Impairing Growth in Children with Severe Atopic Dermatitis
Mohammad S. Ehlayel, Ashraf Soliman
A643 Airways Assessment of Aged Nursing Homes Residents
Pedro Martins, João Marques, Joana Gomes-Belo, Teresa Palmeiro, Iolanda Caires, Joana Belo, Maria Amália Botelho, Paula Leiria-Pinto, Nuno Neuparth
A644 Use of Skin Prick Test, Specific IgE to Shrimp and Rpen a1 to Determine Clinical Reaction to Shrimp in Area with High Prevalence of House Dust Mite Sensitization
Narissara Suratannon, Jaichat Mekaroonkamol, Jarungchit Ngamphaiboon, Piyawadee Lertchanaruengrith, Pantipa Chatchatee
A645 Identification of Specific IgE-Binding Proteins in Tree of Heaven (Ailanthus altissima) Pollen
Gholamali Kardar, Ahmad Majd, Youcef Shahali, Farrokh Ghahremaninejad, Zahra Pourpak, Fateme Mousavi
A646 Allergy Immunotherapy Well Tolerated in Children
Mahnaz Sadeghi-Shabestari
A647 Steinert (DM1) Patients Have IgG1 Deficiency and Should be Screened for Immune Deficiency
K. Van Bilsen, O. Manusama, W.a. Dik, M. Van Der Burg, V. H. J. Van Der Velden, V.a.S. H. Dalm, P. M. Van Hagen
A648 The Change of Serous Sige and Three Evaluation before and after Sublingual Immunotherapy with Dermatophagoides Farinae for Persistent Allergic Rhinitis
Yongping Liu
A649 Garlic Extracts Reduce Histamine-Induced Proliferation and Migration of Human Asthmatic Bronchial Smooth Muscle Cells
Yi Yeong Jeong
A650 A Case of Occupational Contact Dermatitis Caused By N-Acetylcysteine
Ji Hye Kim, Moon Gyeong Yoon, Young Min Ye, Yoo Seob Shin, Ga Young Ban, Hae-Sim Park, Hye Min Jung
A651 The Association Between Pollen Change and Asthma Attacks
Soo Yong Roh, Jaechul Song, Ji-Hoon Lee, Hogil Kim, Jae Young Kim, Kyeong Joon Lee
A652 Incidence of Emergency Department Visits and Hospitalizations for Asthma Exacerbations during the Lunar Month in Singapore
Lydia Wong, Mohana Rajakulendran, Haripriya Santhanam, Lynette Shek, Tow Keang Lim
A653 The Prevalence of Positive Reaction for Skin Prick Test in Korean Farmers and Its Occupational Risk Factors
Hogil Kim, Soo-Jin Lee, Ji-Hoon Lee, Soo Yong Roh, Soon-Chan Kwon
A654 Drug Allergy in Children: A Three-Years Experience at Dr. Kariadi Hospital Semarang Indonesia
Wistiani, Galuh H, Ani Wistiani
A655 The Identification of Morphology, Structure and Study of Seasonal Variation of Airborne Fraxinus Excelsior Pollen Grains in the Tehran
Gholam Ali Kardar, Maryam Sharifshoushtari, Ahmad Majd, Taher Nejadsattari, Zahra Pourpak, Mostafa Moin
A656 Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites
Ji Hye Kim, Daehong Seo, Young Min Ye, Hae-Sim Park, Jung-Won Park, Jae-Hyun Lee, Yoo Seob Shin
A657 Healthy Ageing Research Center (HARC) As a Platform for Multidisciplinary Approaches to Respiratory Research in the Elderly
Marek L. Kowalski, Aleksandra Wardzynska, Marcin Kurowski, Malgorzata / Ewa Pawelczyk, Adam Wysokinski, Iwona Kloszewska, Janina Grzegorczyk, Wojciech Piotrowski, Joanna Makowska
A658 Estimation of Cases of Work-Related Asthma Using Capture-Recapture Methods
Soon-Chan Kwon, Jaechul Song, Yong-Kyu Kim
A659 Primary School Students’ Parents Reported ISAAC Questionnaire in a Low Income Area of Ankara
Ilknur Bostanci, Zeynep Sengul Emeksiz, Aysegul Ertugrul, Serap Ozmen, Soner Sahin
A660 Usefulness of PC20 Adenosine Monophosphate in Diagnosis and Treatment in Bronchial Asthma
Sang-Ha Kim, Myoung Kyu Lee, Won Yeon Lee, Suk Joong Yong, Seok Jeong Lee, Ye-Ryung Jung
A661 S100 Calcium Binding Protein A9 in Sputum of Patients with Steroid Naive Asthma: Relation with Airway Obstruction and Nneutrophilc Inflammation
Myung Shin Kim, Jong-Sook Park, An-Soo Jang, Choon-Sik Park
A662 Risk Factor Asthma in Pediatric Pneumonia Patients
Diah Asri Wulandari, Cissy Kartasasmita
A663 Prevalence and Risk Factors of Childhood Asthma and Allergic Disease at Exposed Area By Emission of Cement Padang Factory
Finny Fitry Yani, Rizanda Machmud, Dhina Lydia Lestari
A664 Association Between Serum Level of 25-Hydroxyvitamin D with Atopic Dermatitis Occurrence and Severity in Children
Rusdi Rusdi, Yurmalina Yurmalina, Eryati Darwin
A665 Thiol-Disulfide Balance in Children with Atopic Dermatitis
Ilknur Bostanci, Gulin Karacan, Nazli Ercan, Asuman Colak, Murat Alisik, Gulay Basarir, Ozcan Erel
A666 Recurrent Mouth Ulsers Caused By Braces after Developing a Nickel Allergy in Children
Ilknur Bostanci, Yasemin Keskin
A667 Anaphylactic Reaction to Famotidine with Pheniramine Hypersensitivity
Ilkay Koca Kalkan
A668 Novel Transcriptomic and Immunoproteotomic Approaches in Identifying Cross-Reactive Allergens Between Crustacean and Molluscs
Andreas/Ludwig Lopata, Kyall Zenger, Roni Nugraha, Sandip Kamath
A669 Pollen Season and Climate Change in the Continental United States (CONUS)
Leonard Bielory, Panos Georgopoulos, Yong Zhang, Wheat Mi, Ting Cai
A670 Differences of Change in Der p IgG4 and CD4+CD25+FoxP3+ Treg Cells Between Sublingual and Subcutaneous Immunotherapy with House Dust Mite in Chinese Patients with Allergic Rhinitis
MO Xian, Jing Li, Mulin Feng
doi:10.1186/s40413-016-0096-1
PMCID: PMC4896250
6.  Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice 
The Journal of Experimental Medicine  1995;182(5):1527-1536.
Allergic asthma is characterized by airway hyperresponsiveness and pulmonary eosinophilia, and may be mediated by T helper (Th) lymphocytes expressing a Th2 cytokine pattern. Interleukin (IL) 12 suppresses the expression of Th2 cytokines and their associated responses, including eosinophilia, serum immunoglobulin E, and mucosal mastocytosis. We have previously shown in a murine model that antigen- induced increases in airway hyperresponsiveness and pulmonary eosinophilia are CD4+ T cell dependent. We used this model to determine the ability of IL-12 to prevent antigen-induced increases in airway hyperresponsiveness, bronchoalveolar lavage (BAL) eosinophils, and lung Th2 cytokine expression. Sensitized A/J mice developed airway hyperresponsiveness and increased numbers of BAL eosinophils and other inflammatory cells after single or repeated intratracheal challenges with sheep red blood cell antigen. Pulmonary mRNA and protein levels of the Th2 cytokines IL-4 and IL-5 were increased after antigen challenge. Administration of IL-12 (1 microgram/d x 5 d) at the time of a single antigen challenge abolished the airway hyperresponsiveness and pulmonary eosinophilia and promoted an increase in interferon (IFN) gamma and decreases in IL-4 and IL-5 expression. The effects of IL-12 were partially dependent on IFN-gamma, because concurrent treatment with IL-12 and anti-IFN-gamma monoclonal antibody partially reversed the inhibition of airway hyperresponsiveness and eosinophilia by IL-12. Treatment of mice with IL-12 at the time of a second antigen challenge also prevented airway hyperresponsiveness and significantly reduced numbers of BAL inflammatory cells, reflecting the ability of IL-12 to inhibit responses associated with ongoing antigen-induced pulmonary inflammation. These data show that antigen-induced airway hyperresponsiveness and inflammation can be blocked by IL-12, which suppresses Th2 cytokine expression. Local administration of IL-12 may provide a novel immunotherapy for the treatment of pulmonary allergic disorders such as atopic asthma.
PMCID: PMC2192202  PMID: 7595222
7.  Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma 
Background
Allergic asthma is a chronic inflammatory lung disease that is characterized by airway hyperresponsiveness (AHR) to allergens, airway oedema, increased mucus secretion, excess production of T helper-2 (Th2) cytokines, and eosinophil accumulation in the lungs. Corni fructus (CF) is a fruit of Cornus officinalis Sieb. Et. Zucc. (Cornaceae) and has been used in traditional Korean medicine as an anti-inflammatory, analgesic, and diuretic agent. To investigate the anti-asthmatic effects of CF and their underlying mechanism, we examined the influence of CF on the development of pulmonary eosinophilic inflammation and airway hyperresponsiveness in a mouse model of allergic asthma.
Methods
In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) by intraperitoneal (i.p.), intratracheal (i.t.) injections and intranasal (i.n.) inhalation of OVA. We investigated the effect of CF on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, and OVA-specific immunoglobulin E (IgE) production.
Results
The CF-treated groups showed suppressed eosinophil infiltration, allergic airway inflammation, and AHR via reduced production of interleuin (IL) -5, IL-13, and OVA-specific IgE.
Conclusions
Our data suggest that the therapeutic effects of CF in asthma are mediated by reduced production of Th2 cytokines (IL-5), eotaxin, and OVA-specific IgE and reduced eosinophil infiltration.
doi:10.1186/1476-9255-9-9
PMCID: PMC3328291  PMID: 22439901
Corni fructus; Asthma; Eosinophil; IL-5; CCR3
8.  Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. 
Journal of Clinical Investigation  1997;100(1):226-233.
Viral respiratory infections can predispose to the development of asthma by mechanisms that are presently undetermined. Using a murine model of respiratory syncytial virus (RSV) infection, acute infection is associated with airway hyperresponsiveness as well as enhanced responses to subsequent sensitization to allergen. We demonstrate that acute viral infection results in increased airway responsiveness to inhaled methacholine and pulmonary neutrophilic and eosinophilic inflammation. This response is associated with predominant production of Th-1-type cytokines in peribronchial lymph node cells in vitro. Mice sensitized to ovalbumin via the airways after RSV infection developed increased airway responsiveness to methacholine and pulmonary eosinophilic and neutrophilic inflammation, associated with the predominant production of Th-2-type cytokines. Treatment of the mice with anti-IL-5 antibody abolished airway hyperresponsiveness and eosinophilic but not neutrophilic inflammation in both acutely infected mice and mice sensitized after infection. We conclude that RSV infection results in airway hyperresponsiveness in the acute phase and leads to changes in immune function that can enhance the effects of airway sensitization to antigen after infection. In both situations, airway hyperresponsiveness is closely associated with pulmonary eosinophilic inflammation. This model provides a means for further analyzing the influence of viral respiratory infections on airway sensitization and the development of altered airway responsiveness.
PMCID: PMC508183  PMID: 9202075
9.  Anti-Malarial Drug Artesunate Attenuates Experimental Allergic Asthma via Inhibition of the Phosphoinositide 3-Kinase/Akt Pathway 
PLoS ONE  2011;6(6):e20932.
Background
Phosphoinositide 3-kinase (PI3K)/Akt pathway is linked to the development of asthma. Anti-malarial drug artesunate is a semi-synthetic derivative of artemisinin, the principal active component of a medicinal plant Artemisia annua, and has been shown to inhibit PI3K/Akt activity. We hypothesized that artesunate may attenuate allergic asthma via inhibition of the PI3K/Akt signaling pathway.
Methodology/Principal Findings
Female BALB/c mice sensitized and challenged with ovalbumin (OVA) developed airway inflammation. Bronchoalveolar lavage fluid was assessed for total and differential cell counts, and cytokine and chemokine levels. Lung tissues were examined for cell infiltration and mucus hypersecretion, and the expression of inflammatory biomarkers. Airway hyperresponsiveness was monitored by direct airway resistance analysis. Artesunate dose-dependently inhibited OVA-induced increases in total and eosinophil counts, IL-4, IL-5, IL-13 and eotaxin levels in bronchoalveolar lavage fluid. It attenuated OVA-induced lung tissue eosinophilia and airway mucus production, mRNA expression of E-selectin, IL-17, IL-33 and Muc5ac in lung tissues, and airway hyperresponsiveness to methacholine. In normal human bronchial epithelial cells, artesunate blocked epidermal growth factor-induced phosphorylation of Akt and its downstream substrates tuberin, p70S6 kinase and 4E-binding protein 1, and transactivation of NF-κB. Similarly, artesunate blocked the phosphorylation of Akt and its downstream substrates in lung tissues from OVA-challenged mice. Anti-inflammatory effect of artesunate was further confirmed in a house dust mite mouse asthma model.
Conclusion/Significance
Artesunate ameliorates experimental allergic airway inflammation probably via negative regulation of PI3K/Akt pathway and the downstream NF-κB activity. These findings provide a novel therapeutic value for artesunate in the treatment of allergic asthma.
doi:10.1371/journal.pone.0020932
PMCID: PMC3111464  PMID: 21695271
10.  Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation 
British Journal of Pharmacology  2005;144(8):1100-1108.
An emerging body of evidence indicates that PGE2 has a privileged anti-inflammatory role within the airways. Stimulants of protease-activated receptor-2 (PAR2) inhibit airway smooth muscle tone in vitro and in vivo predominantly via cyclooxygenase (COX)-dependent generation of prostaglandin E2 (PGE2). Thus, the current study tested the hypothesis that PAR2-induced generation of PGE2 inhibits the development of allergic airways inflammation and hyperresponsiveness.Bronchoalveolar lavage (BAL) fluid recovered from ovalbumin (OVA)-sensitised and -challenged (allergic) mice contained elevated numbers of eosinophils, which peaked at 48 h postchallenge. Intranasal (i.n.) administration of a PAR2-activating peptide (PAR2-AP) SLIGRL (25 mg kg−1, at the time of OVA challenge) caused a 70% reduction in the numbers of BAL eosinophils (compared to the scrambled peptide LSIGRL, 25 mg kg−1).Pretreatment of allergic mice with either indomethacin (1 mg kg−1, dual COX inhibitor) or nimesulide (3 mg kg−1, COX-2-selective inhibitor) blocked SLIGRL-induced reductions in BAL eosinophils.I.n. SLIGRL, but not LSIGRL, inhibited the development of antigen-induced airways hyperresponsiveness. The inhibitory effect of SLIGRL was blocked by indomethacin.Exposure of isolated tracheal preparations from allergic mice to 100 μM SLIGRL was associated with a 5.0-fold increase in PGE2 levels (P<0.05, compared to 100 μM LSIGRL). SLIGRL induced similar increases in PGE2 levels in control mice (OVA-sensitised, saline-challenged).I.n. administration of PGE2 (0.15 mg kg−1) to allergic mice significantly inhibited eosinophilia and airways hyperresponsiveness to methacholine.In anaesthetised, ventilated allergic mice, SLIGRL (5 mg kg−1, i.v.) inhibited methacholine-induced increases in airways resistance. Consistent with this bronchodilator effect, SLIGRL induced pronounced relaxation responses in isolated tracheal preparations obtained from allergic mice. LSIGRL did not inhibit bronchomotor tone in either of these in vivo or in vitro experiments.In summary, a PAR2-AP SLIGRL inhibited the development of airway eosinophilia and hyperresponsiveness in allergic mice through a COX-dependent pathway involving COX-2-mediated generation of the anti-inflammatory mediator PGE2. SLIGRL also displayed bronchodilator activity in allergic mice. These studies support the concept that PAR2 exerts predominantly bronchoprotective actions within allergic murine airways.
doi:10.1038/sj.bjp.0706150
PMCID: PMC1576095  PMID: 15700024
Protease-activated receptor; allergic inflammation; airway hyperresponsiveness; eosinophils; SLIGRL; cyclooxygenase, prostaglandin E2; indomethacin; bronchoalveolar lavage
11.  Inhibition of Pim1 Kinase Activation Attenuates Allergen-Induced Airway Hyperresponsiveness and Inflammation 
Pim kinases are a family of serine/threonine kinases whose activity can be induced by cytokines involved in allergy and asthma. These kinases play a role in cell survival and proliferation, but have not been examined, to the best of our knowledge, in the development of allergic disease. This study sought to determine the role of Pim1 kinase in the development of allergic airway responses. Mice were sensitized and challenged with antigen (primary challenge), or were sensitized, challenged, and rechallenged with allergen in a secondary model. To assess the role of Pim1 kinase, a small molecule inhibitor was administered orally after sensitization and during the challenge phase. Airway responsiveness to inhaled methacholine, airway and lung inflammation, cell composition, and cytokine concentrations were assessed. Lung Pim1 kinase concentrations were increased after ovalbumin sensitization and challenge. In the primary allergen challenge model, treatment with the Pim1 kinase inhibitor after sensitization and during airway challenges prevented the development of airway hyperresponsiveness, eosinophilic airway inflammation, and goblet cell metaplasia, and increased Th2 cytokine concentrations in bronchoalveolar fluid in a dose-dependent manner. These effects were also demonstrated after a secondary allergen challenge, where lung allergic disease was established before treatment. After treatment with the inhibitor, a significant reduction was evident in the number of CD4+ and CD8+ T cells and concentrations of cytokines in the airways. The inhibition of Pim1 kinase was effective in preventing the development of airway hyperresponsiveness, airway inflammation, and cytokine production in allergen-sensitized and allergen-challenged mice. These data identify the important role of Pim1 kinase in the full development of allergen-induced airway responses.
doi:10.1165/rcmb.2011-0190OC
PMCID: PMC3359953  PMID: 22074702
airway hyperresponsiveness; inflammation; Pim1 kinase; T cells
12.  Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells1 
Regulatory T cells (Treg) play a decisive role in many diseases including asthma and allergen-induced lung inflammation. However, little progress has been made developing new therapeutic strategies for pulmonary disorders. In the current study we demonstrate that cytokine:antibody complexes of IL-2 and anti-IL-2 mAb reduce the severity of allergen-induced inflammation in the lung by expanding Tregs in vivo. Unlike rIL-2 or anti-IL-2 mAb treatment alone, IL-2:anti-IL-2 complexes dampened airway inflammation and eosinophilia while suppressing IL-5 and eotaxin-1 production. Mucus production, airway hyperresponsiveness to methacholine, and parenchymal tissue inflammation were also dramatically reduced following IL-2:anti-IL-2 treatment. The suppression in allergic airway disease was associated with a marked expansion of Tregs (IL-10+CD4+CD25+ and Foxp3+CD4+CD25+) in the tissues, with a corresponding decrease in effector T cell responses. The ability of IL-2:anti-IL-2 complexes to suppress airway inflammation was dependent on Treg-derived IL-10, as IL-10+/+, but not IL-10-/- Tregs, were capable of mediating the suppression. Furthermore, a therapeutic protocol using a model of established airway allergy highlighted the ability of IL-2:anti-IL-2 complexes to expand Tregs and prevent successive airway inflammation and airway hyperresponsiveness. This study suggests that endogenous Treg therapy may be a useful tool to combat the rising incidence of allergic airway disease.
PMCID: PMC2706157  PMID: 18981114
13.  Dissecting asthma pathogenesis through study of patterns of cellular traffic indicative of molecular switches operative in inflammation 
Background:
Inflammation and degeneration are the two edged swords that impale a pulmonary system with the maladies like asthma and idiopathic pulmonary fibrosis. To explore critical role players that orchestrate the etiology and pathogenesis of these diseases, we used various lung disease models in mice in specific genetic knockout templates.
Materials and methods:
Acute and chronic allergic asthma and idiopathic pulmonary fibrosis model in mouse was developed in various genetic knockout templates namely α4Δ/ Δ(α41-/-), β2-/-, and α4-/- β2 mice, and the following parameters were measured to assess development of composite asthma phenotype- (i) airway hyperresponsiveness to methacholine by measuring lung resistance and compliance by invasive and Penh by non-invasive plethysmography as well as lung resistance and compliance using invasive plethysmography, (ii) in situ inflammation status in lung parenchyma and lung interstitium and also resultant airway remodelling measured by histochemical staining namely Masson’s Trichrome staining and Hematoxylin&Eosin staining, (iii) formation of metaplastic goblet cells around lung airways by Alcian blue dye, (iv) measurement of Th1 and Th2 cytokines in serum and bronchoalveolar lavage fluid (BALf), (v) serum allergen-specific IgE. Specifically, ovalbumin-induced acute allergic asthma model in mice was generated in WT (wildtype) and KO (knockout) models and readouts of the composite asthma phenotype viz. airway hypersensitivity, serum OVA-specific IgE and IgG, Th2 cytokine in bronchoalveolar lavage fluid (BALf) and lymphocyte cell subsets viz. T, B cells, monocytes, macrophages, basophils, mast cells and eosinophils (by FACS and morphometry in H&E stained cell smears) were assessed in addition to lung and lymph node histology.
Results:
We noticed a pattern of cellular traffic between bone marrow (BM)→ peripheral blood (PB) → lung parenchyma (LP) → (BALf) in terms of cellular recruitment of key cell sub-types critical for onset and development of the diseases which is different for maintenance and exacerbations in chronic cyclically occurring asthma that leads to airway remodelling. While inflammation is the central theme of this particular disease, degeneration and shift in cellular profile, subtly modifying the clinical nature of the disease were also noted. In addition we recorded the pattern of cell movement between the secondary lymphoid organs namely, the cervical, axillary, ingunal, and mesenteric lymph nodes vis-à-vis spleen and their sites of poiesis BM, PB and lung tissue. While mechanistic role is the chief domain of the integrins (α4 i.e. VLA-4 or α4β1, VCAM-1; β2 i.e. CD18 or ICAM-1).
Concluding remarks:
The present paper thoroughly compares and formulates the pattern of cellular traffic among the three nodes of information throughput in allergic asthma immunobiology, namely, primary lymphoid organs (PLO), secondary lymphoid organs (SLO), and tissue spaces and cells where inflammation and degeneration is occurring within the purview of the disease pathophysiological onset and ancillary signals in the above models and reports some interesting findings with respect to adult lung stem cell niches and its resident progenitors and their role in pathogenesis and disease amelioration.
doi:10.7603/s40855-015-0001-2
PMCID: PMC4959125  PMID: 27512648
Bone marrow; Mesenchymal stem cell; GMP; Serum free medium; Platelet rich plasma
14.  Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation 
Rationale: Eosinophils are key effector cells in allergic diseases, including allergic rhinitis, eczema, and asthma. Their tissue presence is regulated by both recruitment and increased longevity at inflamed sites.
Objectives: To investigate the ability of the flavone wogonin to induce eosinophil apoptosis in vitro and attenuate eosinophil-dominant allergic inflammation in vivo in mice.
Methods: Human and mouse eosinophil apoptosis in response to wogonin was investigated by cellular morphology, flow cytometry, mitochondrial membrane permeability, and pharmacological caspase inhibition. Allergic lung inflammation was modeled in mice sensitized and challenged with ovalbumin. Bronchoalveolar lavage (BAL) and lung tissue were examined for inflammation, mucus production, and inflammatory mediator production. Airway hyperresponsiveness to aerosolized methacholine was measured.
Measurements and Main Results: Wogonin induced time- and concentration-dependent human and mouse eosinophil apoptosis in vitro. Wogonin-induced eosinophil apoptosis occurred with activation of caspase-3 and was inhibited by pharmacological caspase inhibition. Wogonin administration attenuated allergic airway inflammation in vivo with reductions in BAL and interstitial eosinophil numbers, increased eosinophil apoptosis, reduced airway mucus production, and attenuated airway hyperresponsiveness. This wogonin-induced reduction in allergic airway inflammation was prevented by concurrent caspase inhibition in vivo.
Conclusions: Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation, suggesting that it has therapeutic potential for the treatment of allergic inflammation in humans.
doi:10.1164/rccm.201408-1565OC
PMCID: PMC4384778  PMID: 25629436
airway resistance; antiinflammatory agents; hypersensitivity; inflammation resolution; mucus
15.  Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 
Background
Atopic dermatitis (AD) is characterized by local and systemic Th2 responses to cutaneously introduced allergens and is a risk factor for asthma. Blockade of Th2 cytokines has been suggested as therapy for AD.
Objectives
To examine the effect of the absence of IL-4 and IL-13 on the Th-17 response to epicutaneous (EC) sensitization in a mouse model of allergic skin inflammation with features of AD.
Methods
Wild-type (WT), IL-4KO, IL-13KO and IL-4/13 double KO (DKO) mice were subjected to EC sensitization with ovalbumin (OVA) or saline and airway challenged with OVA. Systemic immune responses to OVA, skin and airway inflammation, and airway hyperresponsiveness (AHR) were examined.
Results
OVA sensitized DKO mice exhibited impaired Th2 driven responses with undetectable OVA specific IgE and severely diminished eosinophil infiltration at sensitized skin sites, but intact dermal infiltration with CD4+ cells. DKO mice mounted an exaggerated IL-17A, but normal IFN-γ and IL-5 systemic responses. Airway challenge of these mice with OVA caused marked upregulation of IL-17 mRNA expression in the lungs, increased neutrophilia in bronchoalveolar lavage fluid (BALF), airway inflammation characterized by mononuclear cell infiltration with no detectable eosinophils, and bronchial hyperresponsiveness to methacholine that were reversed by IL-17 blockade. IL-4, but not IL-13, was identified as the major Th2 cytokine that downregulates the IL-17 response in EC sensitized mice.
Conclusion
EC sensitization in the absence of IL-4/IL-13 induces an exaggerated Th17 response systemically, and in lungs following antigen challenge that results in airway inflammation and AHR.
Clinical implications
Blockade of IL-4 may promote IL-17-mediated airway inflammation in AD.
doi:10.1016/j.jaci.2009.07.040
PMCID: PMC2895457  PMID: 19815118
IL-17; Th2 cytokines; atopic dermatitis; asthma
16.  Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses 
Respiratory Research  2013;14(1):8.
Background
Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. In this study, we have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice.
Methods
BALB/c mice were sensitized and challenged (primary) with ovalbumin (OVA). Six weeks later, a single OVA aerosol (secondary challenge) was delivered and airway inflammation and airway responses were monitored 6 and 48 hrs later. An inhibitor of neutrophil elastase was administered prior to secondary challenge.
Results
Mice developed a two-phase airway inflammatory response after secondary allergen challenge, one neutrophilic at 6 hr and the other eosinophilic, at 48 hr. PAR-2 expression in the lung tissues was enhanced following secondary challenge, and that PAR-2 intracellular expression on peribronchial lymph node (PBLN) T cells was also increased following allergen challenge of sensitized mice. Inhibition of neutrophil elastase significantly attenuated AHR, goblet cell metaplasia, and inflammatory cell accumulation in the airways following secondary OVA challenge. Levels of IL-4, IL-5 and IL-13, and eotaxin in BAL fluid 6 hr after secondary allergen challenge were significantly suppressed by the treatment. At 48 hr, treatment with the neutrophil elastase inhibitor significantly reduced the levels of IL-13 and TGF-β1 in the BAL fluid. In parallel, in vitro IL-13 production was significantly inhibited in spleen cells from sensitized mice.
Conclusion
These data indicate that neutrophil elastase plays an important role in the development of allergic airway inflammation and hyperresponsiveness, and would suggest that the neutrophil elastase inhibitor reduced AHR to inhaled methacholine indicating the potential for its use as a modulator of the immune/inflammatory response in both the neutrophil- and eosinophil-dominant phases of the response to secondary allergen challenge.
doi:10.1186/1465-9921-14-8
PMCID: PMC3570429  PMID: 23347423
Neutrophil; Elastase; Airway; Hyperresponsiveness; Asthma
17.  Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT 
The Journal of Experimental Medicine  2003;198(10):1573-1582.
Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the role of class IA PI3K in antigen-induced airway inflammation and hyperresponsiveness by i.p. administration into mice of Δp85 protein, a dominant negative form of the class IA PI3K regulatory subunit, p85α, which was fused to HIV-TAT (TAT-Δp85). Intraperitoneal administration of TAT-Δp85 caused time-dependent transduction into blood leukocytes, and inhibited activated phosphorylation of protein kinase B (PKB), a downstream target of PI3K, in lung tissues in mice receiving intranasal FMLP. Antigen challenge elicited pulmonary infiltration of lymphocytes, eosinophils and neutrophils, increase in mucus-containing epithelial cells, and airway hyperresponsiveness to methacholine. Except for modest airway neutrophilia, these effects all were blocked by treatment with 3–10 mg/kg of TAT-Δp85. There was also significant reduction in IL-5 and IL-4 secretion into the BAL. Intranasal administration of IL-5 caused eosinophil migration into the airway lumen, which was attenuated by systemic pretreatment with TAT-Δp85. We conclude that PI3K has a regulatory role in Th2-cell cytokine secretion, airway inflammation, and airway hyperresponsiveness in mice.
doi:10.1084/jem.20030298
PMCID: PMC2194122  PMID: 14623911
allergy; cytokines; eosinophils; lung; inflammation
18.  Absence of α4 but not β2 integrins restrains development of chronic allergic asthma using mouse genetic models 
Experimental hematology  2009;37(6):715-727.e3.
Objective
Chronic asthma is characterized by ongoing recruitment of inflammatory cells and airway hyperresponsiveness leading to structural airway remodeling. Although α4β1 and β2 integrins regulate leukocyte migration in inflammatory diseases and play decisive roles in acute asthma, their role has not been explored under the chronic asthma setting. To extend our earlier studies with α4Δ/Δ and β2−/− mice, which showed that both a4 and b2 integrins have nonredundant regulatory roles in acute ovalbumin (OVA)-induced asthma, we explored to what extent these molecular pathways control development of structural airway remodeling in chronic asthma.
Materials and Methods
Control, α4Δ/Δ, and β2−/−mouse groups, sensitized by intraperitoneal OVA as allergen, received intratracheal OVA periodically over days 8 to 55 to induce a chronic asthma phenotype. Post-OVA assessment of inflammation and pulmonary function (airway hyperresponsiveness), together with airway modeling measured by goblet cell metaplasia, collagen content of lung, and transforming growth factor β1 expression in lung homogenates, were evaluated.
Results
In contrast to control and β2−/− mice, α4Δ/Δ mice failed to develop and maintain the composite chronic asthma phenotype evaluated as mentioned and subepithelial collagen content was comparable to baseline. These data indicate that β2 integrins, although required for inflammatory migration in acute asthma, are dispensable for structural remodeling in chronic asthma.
Conclusion
α4 integrins appear to have a regulatory role in directing transforming growth factor β-induced collagen deposition and structural alterations in lung architecture likely through interactions of Th2 cells, eosinophils, or mast cells with endothelium, resident airway cells, and/or extracellular matrix.
doi:10.1016/j.exphem.2009.03.010
PMCID: PMC3696022  PMID: 19463772
19.  Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. 
Journal of Clinical Investigation  1997;99(6):1329-1339.
In this investigation we have used a mouse model containing certain phenotypic characteristics consistent with asthma and IL-4- and CD40-deficient mice to establish the role of this cytokine and allergen-specific immunoglobulins in the initiation of airways hyperreactivity and morphological changes to the airways in responses to aeroallergen challenge. Sensitization and aerosol challenge of mice with ovalbumin resulted in a severe airways inflammatory response which directly correlated with the induction of extensive airways damage and airways hyperreactivity to beta-methacholine. Inflammatory infiltrates were primarily characterized by the presence of CD4+ T cells and eosinophils. In IL-4-deficient mice, the recruitment of airways eosinophils was impaired, but not abolished in response to aeroallergen. Moreover, the characteristic airways damage and hyperreactivity normally resulting from allergen inhalation were not attenuated. Induction of these structural and functional changes to the airways occurred in the absence of ovalbumin-specific IgE and IgG1, but IgG2a and IgG3 were detected in the sera of IL-4-deficient mice. CD4+ T cells isolated from both wild-type and IL-4-deficient mice given ovalbumin produced significant levels of IL-5 after in vitro stimulation. Treatment of IL-4-deficient mice with anti-IL-5 mAb before aeroallergen challenge abolished blood and airways eosinophilia, lung damage, and airways hyperreactivity. These results indicate that IL-4 is not essential for the development of IL-5-producing CD4+ T cells or for the induction of eosinophilic inflammation and airways damage and hyperreactivity. In response to sensitization and aerosol challenge, CD40-deficient mice did not produce ovalbumin-specific IgE, IgG isotypes, or IgA, and airways inflammation and hyperreactivity were not attenuated. Our results suggest that allergic airways disease can occur via pathways which operate independently of IL-4 and allergen-specific immunoglobulins. Activation of these pathways is intimately associated with IL-5 and eosinophilic inflammation. Such pathways may play a substantive role in the etiology of asthma.
PMCID: PMC507949  PMID: 9077543
20.  Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation 
Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic asthma with an increase in ambient inhalable particulate matter from air pollutants. This is because inhalable particles efficiently deliver airborne allergens deep into the airways, where they can aggravate allergic asthma symptoms. However, the cellular mechanisms by which inhalable particulate allergens (pAgs) potentiate asthmatic symptoms remain unknown, in part because most in vivo and in vitro studies exploring the pathogenesis of allergic asthma use soluble allergens (sAgs). Using a mouse model of allergic asthma, we found that, compared with their sAg counterparts, pAgs triggered markedly heightened airway hyperresponsiveness and pulmonary eosinophilia in allergen-sensitized mice. Mast cells (MCs) were implicated in this divergent response, as the differences in airway inflammatory responses provoked by the physical nature of the allergens were attenuated in MC-deficient mice. The pAgs were found to mediate MC-dependent responses by enhancing retention of pAg/IgE/FcεRI complexes within lipid raft–enriched, CD63+ endocytic compartments, which prolonged IgE/FcεRI-initiated signaling and resulted in heightened cytokine responses. These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice.
doi:10.1172/JCI43584
PMCID: PMC3049384  PMID: 21285515
21.  The Effects of Proresolution of Ellagic Acid in an Experimental Model of Allergic Airway Inflammation 
Mediators of Inflammation  2013;2013:863198.
Asthma is a disease of airway inflammation characterized by airway hyperresponsiveness, eosinophilic inflammation, and hypersecretion of mucus. Ellagic acid, a compound derived from medicinal plants and fruits, has shown anti-inflammatory activity in several experimental disease models. We used the classical experimental model, in BALB/c mice, of sensibilization with ovalbumin to determine the effect of ellagic acid (10 mg/kg; oral route) in the resolution of allergic airways response. Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control. The control group consisted of nonimmunized mice that received challenge with ovalbumin. Ellagic acid and dexamethasone or vehicle (water) were administered before or after intranasal allergen challenge. Ellagic acid accelerated the resolution of airways inflammation by decreasing total leukocytes and eosinophils numbers in the bronchoalveolar lavage fluid (BALF), the mucus production and lung inflammation in part by reducing IL-5 concentration, eosinophil peroxidase (EPO) activity, and P-selectin expression, but not activator protein 1 (AP-1) and nuclear factor kappa B (NF-κB) pathways. In addition, ellagic acid enhanced alveolar macrophage phagocytosis of IgG-OVA-coated beads ex vivo, a new proresolving mechanism for the clearance of allergen from the airways. Together, these findings identify ellagic acid as a potential therapeutic agent for accelerating the resolution of allergic airways inflammation.
doi:10.1155/2013/863198
PMCID: PMC3860142  PMID: 24376308
22.  Expression of IL-4 Receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma 
Background
Airflow in the lungs of patients with allergic asthma is impaired by excessive mucus production and airway smooth muscle contractions. Elevated levels of the cytokines IL-4 and IL-13 are associated with this pathology. In vitro studies have suggested that IL-4 receptor alpha (IL-4Rα) signalling on smooth muscle cells is critical for airway inflammation and airway hyperresponsiveness.
Objective
In order to define the contribution of IL-4 and IL-13 to the onset of asthmatic pathology the role of their key receptor IL-4Rα in smooth muscle cells was examined in vivo.
Methods
By using transgenic SMC-MHCcreIL-4Rα−/lox mice deficient for IL-4Rα in smooth muscle cells, in vivo effects of impaired IL-4Rα signalling in smooth muscle cells on the outcome of asthmatic disease were investigated for the first time. Allergic asthma was introduced in mice by repeated sensitisation with ovalbumin/aluminium hydroxide on days 0, 7 and 14 followed by intranasal allergen challenge on days 21–23. Mice were investigated for the presence of airway hyperresponsiveness, airway inflammation, allergen specific antibody production, Th2 type cytokine responses and lung pathology.
Results
Airway hyperresponsiveness, airway inflammation, mucus production, Th2 cytokine production and specific antibody responses were unaffected in SMC-MHCcreIL-4Rα−/lox mice when compared to control animals.
Conclusion
The impairment of IL-4Rα on smooth muscle cells had no effect on major aetiological markers of allergic asthma. These findings suggest that IL-4Rα responsiveness in airway smooth muscle cells during the early phase of allergic asthma is not, as suggested, necessary for the outcome of the disease.
Clinical Implications
Therapies targeting the IL-4Rα might have no direct effect on smooth muscle cells in an allergic asthma response.
doi:10.1016/j.jaci.2010.04.028
PMCID: PMC2917502  PMID: 20579713
Smooth muscle cell; Allergy; Asthma; Cytokine Receptors; IL-4; IL-13; gene-deficient mice
23.  Ca2+-Activated K+ Channel–3.1 Blocker TRAM-34 Attenuates Airway Remodeling and Eosinophilia in a Murine Asthma Model 
Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial collagen deposition, airway fibrosis, and increased bronchial smooth muscle (BSM) mass. The calcium-activated K+ channel KCa3.1 is expressed by many cells implicated in the pathogenesis of asthma, and is involved in both inflammatory and remodeling responses in a number of tissues. The specific KCa3.1 blocker 5-[(2-chlorophenyl)(diphenyl)methyl]-1H-pyrazole (TRAM-34) attenuates BSM cell proliferation, and both mast cell and fibrocyte recruitment in vitro. We aimed to examine the effects of KCa3.1 blockade on BSM remodeling, airway inflammation, and BHR in a murine model of chronic asthma. BALB/c mice were sensitized with intraperitoneal ovalbumin (OVA) on Days 0 and 14, and then challenged with intranasal OVA during Days 14–75. OVA-sensitized/challenged mice received TRAM-34 (120 mg/kg/day, subcutaneous) from Days −7 to 75 (combined treatment), Days −7 to 20 (preventive treatment), or Days 21 to 75 (curative treatment). Untreated mice received daily injections of vehicle (n = 8 per group). Bronchial remodeling was assessed by histological and immunohistochemical analyses. Inflammation was evaluated using bronchoalveolar lavage and flow cytometry. We also determined BHR in both conscious and anesthetized mice via plethysmography. We demonstrated that curative treatment with TRAM-34 abolishes BSM remodeling and subbasement collagen deposition, and attenuates airway eosinophilia. Although curative treatment alone did not significantly reduce BHR, the combined treatment attenuated nonspecific BHR to methacholine. This study indicates that KCa3.1 blockade could provide a new therapeutic strategy in asthma.
doi:10.1165/rcmb.2012-0103OC
PMCID: PMC4035224  PMID: 23204391
asthma; KCa3.1; ion channel; remodeling; smooth muscle
24.  Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma 
Molecular Medicine Reports  2015;12(1):71-76.
Asthma is a serious health problem causing significant mortality and morbidity globally. Persistent airway inflammation, airway hyperresponsiveness, increased immunoglobulin E (IgE) levels and mucus hypersecretion are key characteristics of the condition. Asthma is mediated via a dominant T-helper 2 (Th2) immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma. To investigate the anti-asthmatic potential of afzelin, as well as the underlying mechanisms involved, its anti-asthmatic potential were investigated in a murine model of asthma. In the present study, BALB/c mice were systemically sensitized using ovalbumin (OVA) followed by aerosol allergen challenges. The effect of afzelin on airway hyperresponsiveness, eosinophilic infiltration, Th2 cytokine and OVA-specific IgE production in a mouse model of asthma were investigated. It was found that afzelin-treated groups suppressed eosinophil infiltration, allergic airway inflammation, airway hyperresponsiveness, OVA-specific IgE and Th2 cytokine secretion. The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production.
doi:10.3892/mmr.2015.3391
PMCID: PMC4438945  PMID: 25738969
asthma; immunoglobulin E; airway hyperresponsiveness; T-helper 2; eosinophil; GATA-binding protein 3
25.  Differential Effects of Allergen Challenge on Large and Small Airway Reactivity in Mice 
PLoS ONE  2013;8(9):e74101.
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic allergic airways disease to induce inflammation and remodelling and determine whether in vivo hyperresponsiveness to methacholine is consistent with in vitro reactivity of trachea and small airways. Balb/C mice were sensitised (days 0, 14) and challenged (3 times/week, 6 weeks) with ovalbumin. Airway reactivity was compared with saline-challenged controls in vivo assessing whole lung resistance, and in vitro measuring the force of tracheal contraction and the magnitude/rate of small airway narrowing within lung slices. Increased airway inflammation, epithelial remodelling and fibrosis were evident following allergen challenge. In vivo hyperresponsiveness to methacholine was maintained in isolated trachea. In contrast, methacholine induced slower narrowing, with reduced potency in small airways compared to controls. In vitro incubation with IL-1/TNFα did not alter reactivity. The hyporesponsiveness to methacholine in small airways within lung slices following chronic ovalbumin challenge was unexpected, given hyperresponsiveness to the same agonist both in vivo and in vitro in tracheal preparations. This finding may reflect the altered interactions of small airways with surrounding parenchymal tissue after allergen challenge to oppose airway narrowing and closure.
doi:10.1371/journal.pone.0074101
PMCID: PMC3765301  PMID: 24040180

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