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1.  Pharmacokinetic and clinical considerations in the choice of a hypnotic 
British Journal of Clinical Pharmacology  1983;16(Suppl 1):5S-10S.
1 Not only has insomnia become much more frequent in the last hundred years but its causes have also changed considerably.
2 In the treatment of insomnia, benzodiazepines—because of their additional anxiolytic effect—offer substantial advantages over other sleep-inducing agents.
3 The residual fraction—the quotient of plasma concentration at 12 h after drug intake to maximum plasma concentration—makes it possible to differentiate between the benzodiazepines according to their suitability as anxiolytics or hypnotics.
4 Midazolam has the lowest residual fraction of all known benzodiazepines and thus, administered in the appropriate dosage, also has the shortest duration of activity.
PMCID: PMC1428092  PMID: 6138081

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