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On February 23, 2018, PubMed Central Canada (PMC Canada) will be taken offline permanently. No author manuscripts will be deleted, and the approximately 2,900 manuscripts authored by Canadian Institutes of Health Research (CIHR)-funded researchers currently in the archive will be copied to the National Research Council’s (NRC) Digital Repository over the coming months. These manuscripts along with all other content will also remain publicly searchable on PubMed Central (US) and Europe PubMed Central, meaning such manuscripts will continue to be compliant with the Tri-Agency Open Access Policy on Publications.

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1.  Abstracts from the 10th C1-inhibitor deficiency workshop 
Schmaier, Alvin H. | Cicardi, Marco | Reshef, Avner | Moldovan, Dumitru | Mócsai, Attila | López-Trascasa, Margarita | Lera, Alberto López | Brown, Nancy J. | Germenis, Anastasios E. | Filippelli-Silva, Rafael | Duarte, Diego A. | Martin, Renan P. | Veronez, Camila L. | Bouvier, Michel | Bader, Michael | Costa-Neto, Claudio M. | Pesquero, João Bosco | Charest-Morin, Xavier | Marceau, François | Rivard, Georges-É. | Bonnefoy, Arnaud | Wagner, Éric | Debreczeni, Márta L. | Németh, Zsuzsanna | Kajdácsi, Erika | Schwaner, Endre | Cervenak, László | Oroszlán, Gábor | Szilágyi, András | Dani, Ráhel | Závodszky, Péter | Gál, Péter | Dobó, József | Hébert, Jacques | Vincent, Matthieu | Boursiquot, Jean-Nicolas | Chapdeleine, Hugo | Desjardins, Marylin | Laramée, Benoit | Gagnon, Rémi | Payette, Nancy | Lepeshkina, Oleksandra | Charignon, Delphine | Ghannam, Arije | Ponard, Denise | Drouet, Christian | Joseph, Kusumam | Tholanikunnel, Baby G. | Sexton, Daniel J. | Kaplan, Allen P. | Loffredo, Stefania | Bova, Maria | Ferrara, Anne Lise | Petraroli, Angelica | Suffritti, Chiara | Veszeli, Nóra | Zanichelli, Andrea | Farkas, Henriette | Marone, Gianni | Luyasu, Samuel | Favier, Bertrand | Martin, Ludovic | Kőhalmi, Kinga Viktória | Temesszentandrási, György | Várnai, Katalin | Varga, Lilian | Zuraw, Bruce L. | Feussner, Annette | Tortorici, Michael A. | Pawaskar, Dipti | Li, Huamin Henry | Anderson, John | Bernstein, Jonathan A. | Zhang, Ying | Pragst, Ingo | Aygören-Pürsün, Emel | Jacobson, Kraig | Christensen, Jim | Van Leerberghe, Arthur | Wang, Yi | Schranz, Jennifer | Martinez-Saguer, Inmaculada | Soteres, Daniel | Steiner, Urs | Panovska, Vesna Grivcheva | Rae, William | Aberer, Werner | Huissoon, Aarnoud | Bygum, Anette | Magerl, Markus | Graff, Jochen | Longhurst, Hilary | Lleonart, Ramón | Fang, Lei | Cornpropst, Melanie | Clemons, Desiree | Mathis, Amanda | Collis, Phil | Dobo, Sylvia | Sheridan, William P. | Maurer, Marcus | Riedl, Marc A. | Craig, Timothy | Banerji, Aleena | Shennak, Mustafa | Yang, William | Baptista, Jovanna | Busse, Paula | Kalfus, Ira | McDonald, Andrew | Qian, Shawn | Roberts, Anthony | Panousis, Con | Green, Tim | Gille, Andreas | Zamanakou, Maria | Loules, Gedeon | Csuka, Dorottya | Psarros, Fotis | Parsopoulou, Faidra | Speletas, Matthaios | Firinu, Davide | De Pasquale, Tiziana Maria Angela | Zoli, Alessandra | Radice, Anna | Pizzimenti, Stefano | Manoussakis, Emmanouil | Konstantinou, George N. | Bafunno, Valeria | Montinaro, Vincenzo | Cancian, Mauro | Margaglione, Maurizio | Bork, Konrad | Wulff, Karin | Witzke, Guenther | Hardt, Jochen | Bouillet, Laurence | Caballero, Teresa | Grumach, Anete S. | Pommie, Christelle | Andresen, Irmgard | Ettingshausen, Carmen Escuriola | Gutowski, Zeynep | Andritschke, Karin | Linde, Richard | Andrási, Noémi | Szilágyi, Tamás | Leibovich-Nassi, Iris | Symons, Christine | Dempster, John | Boccon-Gibod, Isabelle | Pagnier, Anne | Lehmann, Audrey | Kreiberg, Kristian B. | Nieto, Sandra A. | Martins, Raquel | Martins, Renata | Menendez, Alejandra | Valle, Solange O. R. | Olivares, Margarita | Hernandez-Landeros, Maria E. | Nievas, Elma | Fili, Natalia | Barrera, Olga M. | Bailleau, René | Gallardo-Olivos, Ana Maria | Grau, Masumi | Rodriguez-Galindo, Julian | Carabantes, Marlon J. O. | Zapata-Venegas, Edison | Alfonso, Mario Martinez | Rosario-Grauert, Maria | Ratti, Manuel | Vaszquez, Daniel | Josviack, Dario | Landivar-Salinas, Luis Fernando | Calderón-Llosa, Oscar M. E. | Campilay-Sarmiento, Rolando | Raby, Pablo | Fabiani, Jose | Lumry, William R. | Feuersenger, Henrike | Watson, Douglas J. | Machnig, Thomas | Lamacchia, Donatella | Hernanz, Adriana | Alvez, Ana | Lluncor, Mariana | Pedrosa, Maria | Cabañas, Rosario | Prior, Nieves | Nordenfelt, Patrik | Nilsson, Mats | Lindfors, Anders | Wahlgren, Carl-Fredrik | Björkander, Janne | Hakl, Roman | Kuklínek, Pavel | Krčmová, Irena | Hanzlíková, Jana | Vachová, Martina | Zachová, Radana | Sobotková, Marta | Strenková, Jana | Litzman, Jiří | Palasopoulou, Maria | Tsinti, Gerasimina | Gianni, Panagiota | Kompoti, Maria | Garrido, Sofia | Dyga, Wojciech | Bogdali, Anna | Obtułowicz, Aleksander | Tomasz, Mikolajczyk | Czarnobilska, Ewa | Obtulowicz, Krystyna | Książek, Teofila | Koncz, Anna | Gulyás, Dominik | Staevska, Maria | Jesenak, Milos | Hrubiskova, Katarina | Bellizzi, L. | Relan, A. | Wu, Maddalena A. | Castelli, Antonio | Colombo, Riccardo | Podda, Gianmarco | Del Medico, Marta | Catena, Emanuele | Casella, Francesco | Perego, Francesca | Afifi, Nada Afifi | Tobaldini, Eleonora | Montano, Nicola | Sánchez-Jareño, Marta | Stobiecki, Marcin | Obtułowicz, Krystyna | Guryanova, Irina | Polyakova, Ekaterina | Lebedz, Viktar | Salivonchik, Andrej | Aleshkevich, Svetlana | Belevtsev, Mikhail | Nordmann-Kleiner, Melanie | Trainotti, Susanne | Hahn, Janina | Greve, Jens | Zabrodska, Liudmyla | Alonso, Maria L. Oliva | Tórtora, Rosangela P. | França, Alfeu T. | Ribeiro, Marcia G. | Fu, Lisa | Kanani, Amin | Lacuesta, Gina | Waserman, Susan | Betschel, Stephen | Espinosa, Melissa I. | Contreras, Francisco A. | Hrubisko, Martin | Vavrova, Ludmila | Banovcin, Peter | Ayazi, Maryam | Fazlollahi, Mohammad Reza | Saghafi, Shiva | Mohammadian, Sajedeh | Deshiry, Susan Nabilou | Bidad, Kiana | Shoormasti, Raheleh Shokouhi | Mohammadzadeh, Iraj | Bemanian, Mohammad Hassan | Mahdaviani, Seyed Alireza | Pourpak, Zahra | Valerieva, Anna | Vasileva, Mariela | Velikova, Tsvetelina | Petkova, Elena | Dimitrov, Vasil | Di Maulo, Ruggero | Somech, Raz | Golander, Hava | Sifuentes, Erika J. | Mansard, Catherine | Gompel, Anne | Floccard, Bernard | Blanchard-Delaunay, Claire | Launay, David | Fain, Olivier | Sobel, Alain | Gayet, Stéphane | Amarger, Stéphanie | Armengol, Guillaume | Ollivier, Yann | Zélinsky-Gurung, Ariane | Jeandel, Pierre-Yves | Kanny, Gisèle | Coppéré, Brigitte | Dubrel, Marie | Pelletier, Fabien | Du Thanh, Aurélie | Trouiller, Sébastien | Laurent, Jérôme | De Moreuil, Claire | Pajot, Christine Audouin | Belot, Alexandre | Rodríguez, Ana | Roa, Dasha | Prieto, Alicia | Baeza, Maria Luisa | Krusheva, Borislava | Almeida, Stephanie K. A. | Constantino-Silva, Rosemeire N. | Melo, Nyla | Simoes, Joanna Araujo | Palma, Sandra Mitie U. | da Silva, Jane | de Azevedo, Bruna F. | Mansour, Eli | González-Quevedo, Teresa | Marcos, Carmen | Lobera, Teófilo | de San Pedro, Blanca Sáenz | Avilla, Ernie | Badiou, Jacquie | Binkley, Karen | Borici-Mazi, Rozita | Howlett, Linda | Keith, Paul K. | Rowe, Anne | Waite, Peter | Billebeau, Aurore | Boccon-Gibbod, Isabelle | Lis, Kristina | Laitman, Yael | Friedman, Eitan | Gokmen, N. M. | Gulbahar, O. | Onay, H. | Koc, Z. P. | Sin, A. Z.
doi:10.1186/s13223-017-0198-5
PMCID: PMC5496025
2.  Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016 
Alsayegh, Mohammad A. | Alshamali, Hanan | Khadada, Mousa | Ciccolini, Amanda | Ellis, Anne K. | Quint, Diana | Powley, William | Lee, Laurie | Fiteih, Yahya | Baksh, Shairaz | Vliagoftis, Harissios | Gerega, Sebastien K. | Millson, Brad | Charland, Katia | Barakat, Stephane | Sun, Xichun | Jimenez, Ricardo | Waserman, Susan | FitzGerald, Mark J. | Hébert, Jacques | Cognet-Sicé, Josiane | Renahan, Kevin E. | Huq, Saiful | Chooniedass, Rishma | Sawyer, Scott | Pasterkamp, Hans | Becker, Allan | Smith, Steven G. | Zhang, Shiyuan | Jayasundara, Kavisha | Tacon, Claire | Simidchiev, Alex | Nadeau, Gilbert | Gunsoy, Necdet | Mullerova, Hana | Albers, Frank | Kim, Young Woong | Shannon, Casey P. | Singh, Amrit | Neighbour, Helen | Larché, Mark | Tebbutt, Scott J. | Klopp, Annika | Vehling, Lorena | Becker, Allan B. | Subbarao, Padmaja | Mandhane, Piushkumar J. | Turvey, Stuart E. | Sears, Malcolm R. | Azad, Meghan B. | Loewen, Keely | Monchka, Barret | Mahmud, Salaheddin M. | Jong, Geert ‘t | Longo, Cristina | Bartlett, Gillian | Ducharme, Francine M. | Schuster, Tibor | MacGibbon, Brenda | Barnett, Tracie | North, Michelle L. | Brook, Jeff | Lee, Elizabeth | Omana, Vanessa | Thiele, Jenny | Steacy, Lisa M. | Evans, Greg | Diamond, Miriam | Sussman, Gordon L. | Amistani, Yann | Abiteboul, Kathy | Tenn, Mark W. | Yang, ChenXi | Carlsten, Christopher | Conway, Edward M. | Mack, Douglas | Othman, Yasmin | Barber, Colin M. | Kalicinsky, Chrystyna | Burke, Andrea E. | Messieh, Mary | Nair, Parameswaran | Che, Chun T. | Douglas, Lindsay | Liem, Joel | Duan, Lucy | Miller, Charlotte | Dupuis, Pascale | Connors, Lori A. | Fein, Michael N. | Shuster, Joseph | Hadi, Hani | Polk, Brooke | Raje, Nikita | Labrosse, Roxane | Bégin, Philippe | Paradis, Louis | Roches, Anne Des | Lacombe-Barrios, Jonathan | Mishra, Sanju | Lacuesta, Gina | Chiasson, Meredith | Haroon, Babar | Robertson, Kara | Issekutz, Thomas | Leddin, Desmond | Couban, Stephen | Connors, Lori | Roos, Adrienne | Kanani, Amin | Chan, Edmond S. | Schellenberg, Robert | Rosenfield, Lana | Cvetkovic, Anna | Woodward, Kevin | Quirt, Jaclyn | Watson, Wade T. A. | Castilho, Edson | Sullivan, Jennifer A. | Temple, Beverley | Martin, Donna | Cook, Victoria E. | Mills, Christopher | Portales-Casamar, Elodie | Fu, Lisa W. | Ho, Alexander | Zaltzman, Jeffrey | Chen, Lucy | Vadas, Peter | Gabrielli, Sofianne | Clarke, Ann | Eisman, Harley | Morris, Judy | Joseph, Lawrence | LaVieille, Sebastien | Ben-Shoshan, Moshe | Graham, François | Barnes, Charles | Portnoy, Jay | Stagg, Vincent | Simons, Elinor | Lefebvre, Diana | Dai, David | Mandhane, Piushkumar | Sears, Malcolm | Tam, Herman | Simons, F. Estelle R. | Alotaibi, Dhaifallah | Dawod, Bassel | Tunis, Matthew C. | Marshall, Jean | Desjardins, Marylin | Béland, Marianne | Lejtenyi, Duncan | Drolet, Jean-Phillipe | Lemire, Martine | Tsoukas, Christos | Noya, Francisco J.D. | Alizadehfar, Reza | McCusker, Christine T. | Mazer, Bruce D. | Maestre-Batlle, Danay | Gunawan, Evelyn | Rider, Christopher F. | Bølling, Anette K. | Pena, Olga M. | Suez, Daniel | Melamed, Isaac | Hussain, Iftikhar | Stein, Mark | Gupta, Sudhir | Paris, Kenneth | Fritsch, Sandor | Bourgeois, Christelle | Leibl, Heinz | McCoy, Barbara | Noel, Martin | Yel, Leman | Scott, Ori | Reid, Brenda | Atkinson, Adelle | Kim, Vy Hong-Diep | Roifman, Chaim M. | Grunebaum, Eyal | AlSelahi, Eiman | Aleman, Fernando | Oberle, Amber | Trus, Mike | Sussman, Gordon | Kanani, Amin S. | Chambenoi, Olivier | Chiva-Razavi, Sima | Grodecki, Savannah | Joshi, Nikhil | Menikefs, Peter | Holt, David | Pun, Teresa | Tworek, Damian | Hanna, Raphael | Heroux, Delia | Rosenberg, Elli | Stiemsma, Leah | Turvey, Stuart | Denburg, Judah | Mill, Christopher | Teoh, Timothy | Zimmer, Preeti | Avinashi, Vishal | Paina, Mihaela | Darwish Hassan, Ahmed A. | Oliveria, John Paul | Olesovsky, Chris | Gauvreau, Gail | Pedder, Linda | Keith, Paul K. | Plunkett, Greg | Bolner, Michelle | Pourshahnazari, Persia | Stark, Donald | Vostretsova, Kateryna | Moses, Andrew | Wakeman, Andrew | Singer, Alexander | Gerstner, Thomas | Abrams, Elissa | Johnson, Sara F. | Woodgate, Roberta L.
doi:10.1186/s13223-017-0192-y
PMCID: PMC5390240
3.  Insights and advances in chronic urticaria: a Canadian perspective 
In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification, diagnosis and management of chronic urticaria that have occurred in recent years. These include clarification of the terminology used to describe and classify urticaria. We also detail the development and validation of instruments to assess urticaria and understand the impairment on quality-of-life and the morbidity caused by this disease. Additionally, the approach to management of chronic urticaria now focuses on evidence-based use of non-impairing, non-sedating H1-antihistamines given initially in standard doses and if this is not effective, in up to 4-fold doses. For urticaria refractory to H1-antihistamines, omalizumab treatment has emerged as an effective, safe option.
doi:10.1186/s13223-015-0072-2
PMCID: PMC4336710  PMID: 25705232
Chronic urticaria; Diagnosis; Classification; Management; Immunology; Antihistamines; Up-dosing; Omalizumab
5.  Canadian hereditary angioedema guideline 
Hereditary angioedema (HAE) is a disease which is associated with random and often unpredictable attacks of painful swelling typically affecting the extremities, bowel mucosa, genitals, face and upper airway. Attacks are associated with significant functional impairment, decreased Health Related Quality of Life, and mortality in the case of laryngeal attacks. Caring for patients with HAE can be challenging due to the complexity of this disease. The care of patients with HAE in Canada is neither optimal nor uniform across the country. It lags behind other countries where there are more organized models for HAE management, and where additional therapeutic options are licensed and available for use. The objective of this guideline is to provide graded recommendations for the management of patients in Canada with HAE. This includes the treatment of attacks, short-term prophylaxis, long-term prophylaxis, and recommendations for self-administration, individualized therapy, quality of life, and comprehensive care. It is anticipated that by providing this guideline to caregivers, policy makers, patients and their advocates, that there will be an improved understanding of the current recommendations regarding management of HAE and the factors that need to be considered when choosing therapies and treatment plans for individual patients. The primary target users of this guideline are healthcare providers who are managing patients with HAE. Other healthcare providers who may use this guideline are emergency physicians, gastroenterologists, dentists and otolaryngologists, who will encounter patients with HAE and need to be aware of this condition. Hospital administrators, insurers and policy makers may also find this guideline helpful.
Electronic supplementary material
The online version of this article (doi:10.1186/1710-1492-10-50) contains supplementary material, which is available to authorized users.
doi:10.1186/1710-1492-10-50
PMCID: PMC4210625  PMID: 25352908
Hereditary angioedema; Guideline; Recommendations; Acute attacks; Short-term prophylaxis; Long-term prophylaxis; Self-administration; Individualized therapy; Quality of life; Comprehensive care; GRADE
6.  2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema 
Background
We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.
Objective
To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010).
Methods
The Canadian Hereditary Angioedema Network (CHAEN)/Réseau Canadien d'angioédème héréditaire (RCAH) http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review.
Results
This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference.
Conclusions
Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
doi:10.1186/1710-1492-6-24
PMCID: PMC2921362  PMID: 20667127

Results 1-6 (6)