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On February 23, 2018, PubMed Central Canada (PMC Canada) will be taken offline permanently. No author manuscripts will be deleted, and the approximately 2,900 manuscripts authored by Canadian Institutes of Health Research (CIHR)-funded researchers currently in the archive will be copied to the National Research Council’s (NRC) Digital Repository over the coming months. These manuscripts along with all other content will also remain publicly searchable on PubMed Central (US) and Europe PubMed Central, meaning such manuscripts will continue to be compliant with the Tri-Agency Open Access Policy on Publications.

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1.  A Comparison between Cold Dissection Tonsillectomy and Harmonic Scalpel Tonsillectomy 
PMCID: PMC5785110
Harmonic scalpel; Postoperative Hemorrhage; Tonsillectomy surgical methods; Tonsillectomy
2.  Are Osteopontin and Ki67 Expressions Different in Various Histologic Grades of Meningioma? An Iranian Experience 
Iranian Journal of Pathology  2015;10(4):253-257.
Meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. The aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of Iranian people.
In this cross-sectional study, first, the paraffin blocks with the definite pathological diagnosis of meningioma in 70 patients were cut by microtome, in 4-5 micron sizes and stained for immunohistochemical markers of osteopontin and ki67. Then, all samples were evaluated for positive immunoreactivity and contributing factors.
Among 70 pateints studied, the mean for the Ki67 level was 8.6±12.3 and the mean for the osteopontinm IHC score was 45.2±77.9. There was a high correlation between markers, tumor recurrence and grade (P<0.001). In addition, there was a significant direct correlation between ki67 and osteopontin levels (P<0.001, r=0.760). In other words, as OPN and ki67 expressions increased, the chance of tumor recurrence increased.
ki67 and osteopontin expressions in patients with meningioma can be used as good prognostic markers for tumor recurrence and for distinguishing the grade of meningiomas.
PMCID: PMC4539739  PMID: 26351494
Meningioma; Ki67 Antigen; Osteopontin
3.  Ankle-Brachial Index as a Prognostic Factor and Screening Tool in Coronary Artery Disease: Does it Work? 
Given the lack of consistency in the literature regarding the reliability of the ankle-brachial index (ABI) as a valid screening tool and an independent risk indicator of cardiovascular events and mortality, we compared it with angiography as a reference standard test.
This case-control study, conducted between 2010 and 2011 in Tehran Heart Center, recruited 362 angiographically confirmed cases of coronary artery disease (CAD) and 337 controls. A standard protocol was used to measure the ABI and different CAD risk factors.
A low ABI had specificity of 99.7%, positive predictive value of 95.8%, negative predictive value of 49.8%, sensitivity of 64%, likelihood ratio of 24.07, and odds ratio (OR) of 22.79 (95%CI: 3.06–69.76). The role of the associated risk factors was evaluated with OR (95%CI), with the variables including gender 3.15 (2.30–4.30), cigarette smoking 2.72 (1.86–3.99), family history 1.72 (1.17–2.51), diabetes 1.66 (1.15–2.4), and dyslipidemia 1.38 (1.02–1.88). In a multivariate model, the following variables remained statistically significantly correlated with CAD [OR (95%CI)]: ABI 13.86 (1.78–17.62); gender 3.69 (2.43–5.58); family history of CAD 2.18 (1.41–3.37); smoking 1.69 (1.08–2.64); age 1.04 (1.02–1.06).
A low ABI had specificity of 99.7%; however, because of its low sensitivity (64%), we should consider CAD risk factors associated with a low ABI in order to use it as a first-line screening test.
PMCID: PMC4394056  PMID: 25870642
Ankle brachial index; Coronary artery disease; Risk assessment
4.  Health-Related Quality of Life in Iranian Women with Different Levels of Physical Activity 
Asian Journal of Sports Medicine  2012;3(3):203-207.
One of the most significant current discussions is the effect of different levels of physical activity on health-related quality of life (HRQOL), but there have been no studies in Iran which investigate this issue. The aim of this study was to investigate the relationship between the level of physical activity and HRQOL in Iranian women.
This was an analytical cross-sectional study conducted from October 2010 to January 2011 in Karaj's gymnasiums. We selected gymnasiums using simple randomized sampling. The validated Persian short form 36-item HRQOL questionnaire version 2.0 (SF-36 v2) and the short form of the International Physical Activity Questionnaire were used for data collection. Based on IPAQ, participants were classified into two groups: one with a high level of physical activity (N=240) and another with a moderate level (N = 120).
The group with a high level of physical activity had significantly higher vitality scores (P=0.01) and lower role limitation-physical scores (P=0.02) than the group with a moderate level. The high level of physical activity was associated with considerably higher scores in general health (73.94 ± 0.99 vs.70.82 ± 1.33) (P=0.06) and mental well-being (73.94 ± 1.18 vs.70.88 ± 1.82) (P=0.1) domains than moderate level.
It seems that the high level of physical activity, compared with the moderate level, tends to have positive association with more domains of SF-36 v2.
PMCID: PMC3445649  PMID: 23012641
Physical Activity; Health-Related Quality of Life; Women
5.  Station-based deconstructed training model for teaching procedural skills to medical students: a quasi-experimental study 
Every procedural skill consists of some microskills. One of the effective techniques for teaching a main procedural skill is to deconstruct the skill into a series of microskills and train students on each microskill separately. When we learn microskills, we will learn the main skill also. This model can be beneficial for tuition on procedural skills.
In this study, we propose a stationed-based deconstructed training model for tuition of each microskill, and then we assessed the medical students’ self-perceived abilities.
This quasi-experimental study was conducted in 268 medical students (536 matched pre- and post-questionnaires) at the surgical clerkship stage during five consecutive years in three teaching and learning groups. In this study, we taught each skill in 10 steps (proposed model) to the students. We then evaluated the students’ self-perceived abilities using a pre- and post-self-assessment technique. SPSS v13 software with one-way analysis of variance and paired t-tests were used for data collection and analysis.
Assessment of medical students’ perceived abilities before and after training showed a significant improvement (P < 0.001) in both cognitive and practical domains. There were also significant differences between the three teaching and learning groups (P < 0.001). There were no significant differences for the different years of training regarding the observed improvement.
This study suggests that deconstructing the practical skills into microskills and tuition of those microskills via the separated structured educational stations is effective according to the students’ self-ratings.
PMCID: PMC3643127  PMID: 23745058
clinical skills center; microskills; perceived ability; self-assessment; self-scoring stationed training

Results 1-5 (5)