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1.  Design of Strain-Limiting Substrate Materials for Stretchable and Flexible Electronics 
Advanced functional materials  2016;26(29):5345-5351.
Recently developed classes of electronics for biomedical applications exploit substrates that offer low elastic modulus and high stretchability, to allow intimate, mechanically biocompatible integration with soft biological tissues. A challenge is that such substrates do not generally offer protection of the electronics from high peak strains that can occur upon large-scale deformation, thereby creating a potential for device failure. The results presented here establish a simple route to compliant substrates with strain-limiting mechanics based on approaches that complement those of recently described alternatives. Here, a thin film or mesh of a high modulus material transferred onto a prestrained compliant substrate transforms into wrinkled geometry upon release of the prestrain. The structure formed by this process offers a low elastic modulus at small strain due to the small effective stiffness of the wrinkled film or mesh; it has a high tangent modulus (e.g., >1000 times the elastic modulus) at large strain, as the wrinkles disappear and the film/mesh returns to a flat geometry. This bilinear stress–strain behavior has an extremely sharp transition point, defined by the magnitude of the prestrain. A theoretical model yields analytical expressions for the elastic and tangent moduli and the transition strain of the bilinear stress–strain relation, with quantitative correspondence to finite element analysis and experiments.
PMCID: PMC5639729
2.  Chemical Sensing Systems that Utilize Soft Electronics on Thin Elastomeric Substrates with Open Cellular Designs 
Advanced functional materials  2017;9(3):1605476.
A collection of materials and device architectures are introduced for thin, stretchable arrays of ion sensors that mount on open cellular substrates to facilitate solution exchange for use in biointegrated electronics. The results include integration strategies and studies of fundamental characteristics in chemical sensing and mechanical response. The latter involves experimental measurements and theoretical simulations that establish important considerations in the design of low modulus, stretchable properties in cellular substrates, and in the realization of advanced capabilities in spatiotemporal mapping of chemicals' gradients. As the chemical composition of extracellular fluids contains valuable information related to biological function, the concepts introduced here have potential utility across a range of skin- and internal-organ-integrated electronics where soft mechanics, fluidic permeability, and advanced chemical sensing capabilities are key requirements.
PMCID: PMC5630126
3.  Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device 
Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.
PMCID: PMC5095436  PMID: 27843395
conformal modulus sensors; skin moduli; epidermis and dermis; electromechanical coupling
4.  Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis 
Cell Cycle  2016;15(19):2576-2584.
Formation of the XY body is believed to prevent recombination between X and Y chromosomes during meiosis. We recently demonstrated that SYCP3-like X-linked 2 (Slx2) could be involved in synaptonemal complex formation as well as XY body maintenance during meiosis. In order to further investigate the role and composition of XY body protein complexes in meiotic processes and spermatogenesis, a yeast 2-hybrid screening was performed, and the tripartite motif protein 27(Trim27) was found to interact with Slx2 and co-localized in the XY body. Trim27 has a tripartite motif (TRIM) consisting of a RING finger, B-box and coiled-coil domains, and is a transcriptional regulator that is expressed in various tumor cell lines. In this study, we showed that Slx2 and Trim27 were highly expressed in meiosis of mouse testis. And the Slx2/Trim27 interaction was confirmed in vivo by co-immunoprecipitation and mammalian 2-hybrid interaction assays. Moreover, cytoimmuno localization experiments revealed that Slx2/Trim27 was co-localized to the XY body of spermatocytes during meiosis, and immunohistochemical results revealed co-localization of Trim27 and γ-H2AX in the XY body of primary spermatocytes in the mouse testis. Trim27 may therefore be a transcriptional regulation protein connecting Slx2 and γ-H2AX, thereby promoting the formation of a more potent XY body protein complex in meiotic processes and spermatogenesis. In conclusion, Trim27 connecting Slx2 may regulate meiotic processes in multiple ways by influencing XY body formation and germ cell proliferation during spermatogenesis.
PMCID: PMC5053551  PMID: 27612028
mouse; spermatogenesis; Slx2; Trim27; XY body
5.  Effects of low-intensity pulsed electromagnetic fields on bone microarchitecture, mechanical strength and bone turnover in type 2 diabetic db/db mice 
Scientific Reports  2017;7:10834.
Type 2 diabetic patients have impaired bone quality, leading to increased fracture risk. Substantial evidence demonstrates that pulsed electromagnetic fields (PEMF) could resist osteopenia/osteoporosis induced by estrogen deficiency and disuse. However, the effects of PEMF on osteopenia/osteoporosis associated with diabetes, especially for more prevalent type 2 diabetes, remain poorly understood. We herein investigated the skeletal effects and mechanisms of PEMF (15 Hz, 20 Gs) on leptin receptor-deficient db/db mice with typical type 2 diabetic symptoms. Our µCT results showed that 12-week PEMF exposure significantly improved both cancellous and cortical bone microarchitecture in db/db mice. Three-point bending and biomechanical indentation testing demonstrated that PEMF improved whole-bone structural properties and tissue-level material properties in db/db mice. PEMF significantly promoted bone formation in db/db mice evidenced by increased serum osteocalcin and bone mineral apposition rate, whereas PEMF exerted no observable alteration in bone resorption. Real-time PCR showed that PEMF upregulated tibial gene expression of osteoblastogenesis-related of canonical Wnt/β-catenin signaling but not osteoclastogenesis-related RANKL-RANK signaling in db/db mice. Our findings demonstrate that PEMF improved bone quantity and quality with obvious anabolic activities in db/db mice, and imply that PEMF might become a clinically applicable treatment modality for improving bone quality in type 2 diabetic patients.
PMCID: PMC5589741  PMID: 28883516
6.  Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study 
Opioids and benzodiazepines are frequently used in the intensive care unit (ICU). Regular use and prolonged exposure to opioids in ICU patients followed by abrupt tapering or cessation may lead to iatrogenic withdrawal syndrome (IWS). IWS is well described in pediatrics, but no prospective study has evaluated this syndrome in adult ICU patients. The objective of this study was to determine the incidence of IWS caused by opioids in a critically ill adult population. This multicenter prospective cohort study was conducted at two level-1 trauma ICUs between February 2015 and September 2015 and included 54 critically ill patients. Participants were eligible if they were 18 years and older, mechanically ventilated and had received more than 72 h of regular intermittent or continuous intravenous infusion of opioids. For each enrolled patient and per each opioid weaning episode, presence of IWS was assessed by a qualified ICU physician or senior resident according to the 5th edition of Diagnostic and Statistical Manual of Mental Disorders criteria for opioid withdrawal.
The population consisted mostly of males (74.1%) with a median age of 50 years (25th–75th percentile 38.2–64.5). The median ICU admission APACHE II score was 22 (25th–75th percentile 12.0–28.2). The overall incidence of IWS was 16.7% (95% CI 6–27). The median cumulative opioid dose prior to weaning was higher in patients with IWS (245.7 vs. 169.4 mcg/kg, fentanyl equivalent). Patients with IWS were also exposed to opioids for a longer period of time as compared to patients without IWS (median 151 vs. 125 h). However, these results were not statistically significant.
IWS was occasionally observed in this very specific population of mechanically ventilated, critically ill ICU patients. Further studies are needed to confirm these preliminary results and identify risk factors.
PMCID: PMC5581799  PMID: 28866754
Iatrogenic withdrawal syndrome; Opioids; DSM-V; Mechanical ventilation; Critically ill; Intensive care unit; Adult
7.  Moisture-triggered physically transient electronics 
Science Advances  2017;3(9):e1701222.
We present a type of electronics that can be dissolved upon the presence of moisture within a controllable time scale.
Physically transient electronics, a form of electronics that can physically disappear in a controllable manner, is very promising for emerging applications. Most of the transient processes reported so far only occur in aqueous solutions or biofluids, offering limited control over the triggering and degradation processes. We report novel moisture-triggered physically transient electronics, which exempt the needs of resorption solutions and can completely disappear within well-controlled time frames. The triggered transient process starts with the hydrolysis of the polyanhydride substrate in the presence of trace amounts of moisture in the air, a process that can generate products of corrosive organic acids to digest various inorganic electronic materials and components. Polyanhydride is the only example of polymer that undergoes surface erosion, a distinct feature that enables stable operation of the functional devices over a predefined time frame. Clear advantages of this novel triggered transience mode include that the lifetime of the devices can be precisely controlled by varying the moisture levels and changing the composition of the polymer substrate. The transience time scale can be tuned from days to weeks. Various transient devices, ranging from passive electronics (such as antenna, resistor, and capacitor) to active electronics (such as transistor, diodes, optoelectronics, and memories), and an integrated system as a platform demonstration have been developed to illustrate the concept and verify the feasibility of this design strategy.
PMCID: PMC5580884
8.  Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke* 
The Journal of Biological Chemistry  2016;291(35):18370-18383.
An important contributor to brain ischemia is known to be extracellular acidosis, which activates acid-sensing ion channels (ASICs), a family of proton-gated sodium channels. Lines of evidence suggest that targeting ASICs may lead to novel therapeutic strategies for stroke. Investigations of the role of ASICs in ischemic brain injury have naturally focused on the role of extracellular pH in ASIC activation. By contrast, intracellular pH (pHi) has received little attention. This is a significant gap in our understanding because the ASIC response to extracellular pH is modulated by pHi, and activation of ASICs by extracellular protons is paradoxically enhanced by intracellular alkalosis. Our previous studies show that acidosis-induced cell injury in in vitro models is attenuated by intracellular acidification. However, whether pHi affects ischemic brain injury in vivo is completely unknown. Furthermore, whereas ASICs in native neurons are composed of different subunits characterized by distinct electrophysiological/pharmacological properties, the subunit-dependent modulation of ASIC activity by pHi has not been investigated. Using a combination of in vitro and in vivo ischemic brain injury models, electrophysiological, biochemical, and molecular biological approaches, we show that the intracellular alkalizing agent quinine potentiates, whereas the intracellular acidifying agent propionate inhibits, oxygen-glucose deprivation-induced cell injury in vitro and brain ischemia-induced infarct volume in vivo. Moreover, we find that the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
PMCID: PMC5000083  PMID: 27402850
acid sensing ion channel (ASIC); brain; electrophysiology; ischemia; patch clamp
9.  Identifying the tilt angle and correcting the orbital angular momentum spectrum dispersion of misaligned light beam 
Scientific Reports  2017;7:7873.
The axis tilt of light beam in optical system would introduce the dispersion of orbital angular momentum (OAM) spectrum. To deal with it, a two-step method is proposed and demonstrated. First, the tilt angle of optical axis is identified with a deduced relation between the tilt angle and the variation of OAM topological charges with different reference axes, which is obtained with the help of a charge coupled device (CCD) camera. In our experiments, the precision of measured tilt angle is about 10−4 rad with topological charges of −3~3. With the measured angle value, the additional phase delay due to axis tilt can be calculated so that the dispersion of OAM spectrum can be corrected with a simple formula while the optical axis is not aligned. The experimental results indicate that the original OAM spectrum has been successfully extracted for not only the pure state but also the superposed OAM states.
PMCID: PMC5554247  PMID: 28801603
10.  World Congress Integrative Medicine & Health 2017: Part one 
Brinkhaus, Benno | Falkenberg, Torkel | Haramati, Aviad | Willich, Stefan N. | Briggs, Josephine P. | Willcox, Merlin | Linde, Klaus | Theorell, Töres | Wong, Lisa M. | Dusek, Jeffrey | Wu, Darong | Eisenberg, David | Haramati, Aviad | Berger, Bettina | Kemper, Kathi | Stock-Schröer, Beate | Sützl-Klein, Hedda | Ferreri, Rosaria | Kaplan, Gary | Matthes, Harald | Rotter, Gabriele | Schiff, Elad | Arnon, Zahi | Hahn, Eckhard | Luberto, Christina M. | Martin, David | Schwarz, Silke | Tauschel, Diethard | Flower, Andrew | Gramminger, Harsha | Gupta, Hedwig H. | Gupta, S. N. | Kerckhoff, Annette | Kessler, Christian S. | Michalsen, Andreas | Kessler, Christian S. | Kim, Eun S. | Jang, Eun H. | Kim, Rana | Jan, Sae B. | Mittwede, Martin | Mohme, Wiebke | Ben-Arye, Eran | Bonucci, Massimo | Saad, Bashar | Breitkreuz, Thomas | Rossi, Elio | Kebudi, Rejin | Daher, Michel | Razaq, Samaher | Gafer, Nahla | Nimri, Omar | Hablas, Mohamed | Kienle, Gunver Sophia | Samuels, Noah | Silbermann, Michael | Bandelin, Lena | Lang, Anna-Lena | Wartner, Eva | Holtermann, Christoph | Binstock, Maxwell | Riebau, Robert | Mujkanovic, Edin | Cramer, Holger | Lauche, Romy | Michalsen, Andres | Ward, Lesley | Cramer, Holger | Irnich, Dominik | Stör, Wolfram | Burnstock, Geoffrey | Schaible, Hans-Georg | Ots, Thomas | Langhorst, Jost | Lauche, Romy | Sundberg, Tobias | Falkenberg, Torkel | Amarell, Catherina | Amarell, Catherina | Anheyer, Melanie | Eckert, Marion | Eckert, Marion | Ogal, Mercedes | Eckert, Marion | Amarell, Catherina | Schönauer, Annette | Reisenberger, Birgit | Brand, Bernhard | Anheyer, Dennis | Dobos, Gustav | Kroez, Matthias | Martin, David | Matthes, Harald | Ammendola, Aldo | Mao, Jun J. | Witt, Claudia | Yang, Yufei | Dobos, Gustav | Oritz, Miriam | Horneber, Markus | Voiß, Petra | Reisenberger, Birgit | von Rosenstiel, Alexandra | Eckert, Marion | Ogal, Mercedes | Amarell, Catharina | Anheyer, Melanie | Schad, Friedemann | Schläppi, Marc | Kröz, Matthias | Büssing, Arndt | Bar-Sela, Gil | Matthes, Harald | Schiff, Elad | Ben-Arye, Eran | Arnon, Zahi | Avshalomov, David | Attias, Samuel | Schönauer, Annette | Haramati, Aviad | Witt, Claudia | Brinkhaus, Benno | Cotton, Sian | Jong, Miek | Jong, Mats | Scheffer, Christian | Haramati, Aviad | Tauschel, Diethard | Edelhäuser, Friedrich | AlBedah, Abdullah | Lee, Myeong Soo | Khalil, Mohamed | Ogawa, Keiko | Motoo, Yoshiharu | Arimitsu, Junsuke | Ogawa, Masao | Shimizu, Genki | Stange, Rainer | Kraft, Karin | Kuchta, Kenny | Watanabe, Kenji | Bonin, D | Büssing, Arndt | Gruber, Harald | Koch, Sabine | Gruber, Harald | Pohlmann, Urs | Caldwell, Christine | Krantz, Barbara | Kortum, Ria | Martin, Lily | Wieland, Lisa S. | Kligler, Ben | Gould-Fogerite, Susan | Zhang, Yuqing | Wieland, Lisa S. | Riva, John J. | Lumpkin, Michael | Ratner, Emily | Ping, Liu | Jian, Pei | Hamme, Gesa-Meyer | Mao, Xiaosong | Chouping, Han | Schröder, Sven | Hummelsberger, Josef | Wullinger, Michael | Brodzky, Marc | Zalpour, Christoff | Langley, Julia | Weber, Wendy | Mudd, Lanay M. | Wayne, Peter | Witt, Clauda | Weidenhammer, Wolfgang | Fønnebø, Vinjar | Boon, Heather | Steel, Amie | Bugarcic, Andrea | Rangitakatu, Melisa | Steel, Amie | Adams, Jon | Sibbritt, David | Wardle, Jon | Leach, Matthew | Schloss, Janet | Dieze, Helene | Boon, Heather | Ijaz, Nadine | Willcox, Merlin | Heinrich, Michael | Lewith, George | Flower, Andrew | Graz, Bertrand | Adam, Daniela | Grabenhenrich, Linus | Ortiz, Miriam | Binting, Sylvia | Reinhold, Thomas | Brinkhaus, Benno | Andermo, Susanne | Sundberg, Tobias | Falkenberg, Torkel | Nordberg, Johanna Hök | Arman, Maria | Bhasin, Manoj | Fan, Xueyi | Libermann, Towia | Fricchione, Gregory | Denninger, John | Benson, Herbert | Berger, Bettina | Stange, Rainer | Michalsen, Andreas | Martin, David D. | Boers, Inge | Vlieger, Arine | Jong, Miek | Brinkhaus, Benno | Teut, Michael | Ullmann, Alexander | Ortiz, Miriam | Rotter, Gabriele | Binting, Sylvia | Lotz, Fabian | Roll, Stephanie | Canella, Claudia | Mikolasek, Michael | Rostock, Matthias | Beyer, Jörg | Guckenberger, Matthias | Jenewein, Josef | Linka, Esther | Six, Claudia | Stoll, Sarah | Stupp, Roger | Witt, Claudia M. | Chuang, Elisabeth | Kligler, Ben | McKee, Melissa D. | Cramer, Holger | Lauche, Romy | Klose, Petra | Lange, Silke | Langhorst, Jost | Dobos, Gustav | Chung, Vincent C. H. | Wong, Hoi L. C. | Wu, Xin Y. | Wen, Grace Y. G. | Ho, Robin S. T. | Ching, Jessica Y. L. | Wu, Justin C. Y. | Coakley, Amanda | Flanagan, Jane | Annese, Christine | Empoliti, Joanne | Gao, Zishan | Liu, Xugang | Yu, Shuguang | Yan, Xianzhong | Liang, Fanrong | Hohmann, Christoph D. | Steckhan, Nico | Ostermann, Thomas | Paetow, Arion | Hoff, Evelyn | Michalsen, Andreas | Hu, Xiao-Yang | Wu, Ruo-Han | Logue, Martin | Blonde, Clara | Lai, Lily Y. | Stuart, Beth | Flower, Andrew | Fei, Yu-Tong | Moore, Michael | Liu, Jian-Ping | Lewith, George | Hu, Xiao-Yang | Wu, Ruo-Han | Logue, Martin | Blonde, Clara | Lai, Lily Y. | Stuart, Beth | Flower, Andrew | Fei, Yu-Tong | Moore, Michael | Liu, Jian-Ping | Lewith, George | Jeitler, Michael | Zillgen, Hannah | Högl, Manuel | Steckhan, Nico | Stöckigt, Barbara | Seifert, Georg | Michalsen, Andreas | Kessler, Christian | Khadivzadeh, Talat | Bashtian, Maryam Hassanzadeh | Aval, Shapour Badiee | Esmaily, Habibollah | Kim, Jihye | Kim, Keun H. | Klocke, Carina | Joos, Stefanie | Koshak, Abdulrahman | Wie, Li | Koshak, Emad | Wali, Siraj | Alamoudi, Omer | Demerdash, Abdulrahman | Qutub, Majdy | Pushparaj, Peter | Heinrich, Michael | Kruse, Sigrid | Fischer, Isabell | Tremel, Nadine | Rosenecker, Joseph | Leung, Brenda | Takeda, Wendy | Liang, Ning | Feng, Xue | Liu, Jian-ping | Cao, Hui-juan | Luberto, Christina M. | Shinday, Nina | Philpotts, Lisa | Park, Elyse | Fricchione, Gregory L. | Yeh, Gloria | Munk, Niki | Zakeresfahani, Arash | Foote, Trevor R. | Ralston, Rick | Boulanger, Karen | Özbe, Dominik | Gräßel, Elmar | Luttenberger, Katharina | Pendergrass, Anna | Pach, Daniel | Bellmann-Strobl, Judit | Chang, Yinhui | Pasura, Laura | Liu, Bin | Jäger, Sven F. | Loerch, Ronny | Jin, Li | Brinkhaus, Benno | Ortiz, Miriam | Reinhold, Thomas | Roll, Stephanie | Binting, Sylvia | Icke, Katja | Shi, Xuemin | Paul, Friedemann | Witt, Claudia M. | Rütz, Michaela | Lynen, Andreas | Schömitz, Meike | Vahle, Maik | Salomon, Nir | Lang, Alon | Lahat, Adi | Kopylov, Uri | Ben-Horin, Shomron | Har-Noi, Ofir | Avidan, Benjamin | Elyakim, Rami | Gamus, Dorit | NG, Siew | Chang, Jessica | Wu, Justin | Kaimiklotis, John | Schumann, Dania | Buttó, Ludovica | Langhorst, Jost | Dobos, Gustav | Haller, Dirk | Cramer, Holger | Smith, Caroline | de Lacey, Sheryl | Chapman, Michael | Ratcliffe, Julie | Johnson, Neil | Lyttleton, Jane | Boothroyd, Clare | Fahey, Paul | Tjaden, Bram | van Vliet, Marja | van Wietmarschen, Herman | Jong, Miek | Tröger, Wilfried | Vuolanto, Pia | Aarva, Paulina | Sorsa, Minna | Helin, Kaija | Wenzel, Claudia | Zoderer, Iris | Pammer, Patricia | Simon, Patrick | Tucek, Gerhard | Wode, Kathrin | Henriksson, Roger | Sharp, Lena | Stoltenberg, Anna | Nordberg, Johanna Hök | Xiao-ying, Yang | Wang, Li-qiong | Li, Jin-gen | Liang, Ning | Wang, Ying | Liu, Jian-ping | Balneaves, Lynda | Capler, Rielle | Bocci, Chiara | Guffi, Marta | Paolini, Marina | Meaglia, Ilaria | Porcu, Patrizia | Ivaldi, Giovanni B. | Dragan, Simona | Bucuras, Petru | Pah, Ana M. | Badalica-Petrescu, Marius | Buleu, Florina | Hogea-Stoichescu, Gheorghe | Christodorescu, Ruxandra | Kao, Lan | Cho, Yumin | Klafke, Nadja | Mahler, Cornelia | von Hagens, Cornelia | Uhlmann, Lorenz | Bentner, Martina | Schneeweiss, Andreas | Mueller, Andreas | Szecsenyi, Joachim | Joos, Stefanie | Neri, Isabella | Ortiz, Miriam | Schnabel, Katharina | Teut, Michael | Rotter, Gabriele | Binting, Sylvia | Cree, Margit | Lotz, Fabian | Suhr, Ralf | Brinkhaus, Benno | Rossi, Elio | Baccetti, Sonia | Firenzuoli, Fabio | Monechi, Maria V. | Di Stefano, Mariella | Amunni, Gianni | Wong, Wendy | Chen, Bingzhong | Wu, Justin | Amri, Hakima | Haramati, Aviad | Kotlyanskaya, Lucy | Anderson, Belinda | Evans, Roni | Kligler, Ben | Marantz, Paul | Bradley, Ryan | Booth-LaForce, Cathryn | Zwickey, Heather | Kligler, Benjamin | Brooks, Audrey | Kreitzer, Mary J. | Lebensohn, Patricia | Goldblatt, Elisabeth | Esmel-Esmel, Neus | Jiménez-Herrera, Maria | Ijaz, Nadine | Boon, Heather | Jocham, Alexandra | Stock-Schröer, Beate | Berberat, Pascal O. | Schneider, Antonius | Linde, Klaus | Masetti, Morgana | Murakozy, Henriette | Van Vliet, Marja | Jong, Mats | Jong, Miek | Agdal, Rita | Atarzadeh, Fatemeh | Jaladat, Amir M. | Hoseini, Leila | Amini, Fatemeh | Bai, Chen | Liu, Tiegang | Zheng, Zian | Wan, Yuxiang | Xu, Jingnan | Wang, Xuan | Yu, He | Gu, Xiaohong | Daneshfard, Babak | Nimrouzi, Majid | Tafazoli, Vahid | Alorizi, Seyed M. Emami | Saghebi, Seyed A. | Fattahi, Mohammad R. | Salehi, Alireza | Rezaeizadeh, Hossein | Zarshenas, Mohammad M. | Nimrouzi, Majid | Fox, Kealoha | Hughes, John | Kostanjsek, Nenad | Espinosa, Stéphane | Lewith, George | Fisher, Peter | Latif, Abdul | Lefeber, Donald | Paske, William | Öztürk, Ali Ö. | Öztürk, Gizemnur | Boers, Inge | Tissing, Wim | Naafs, Marianne | Busch, Martine | Jong, Miek | Daneshfard, Babak | Sanaye, Mohammad R. | Dräger, Kilian | Fisher, Peter | Kreitzer, Mary J. | Evans, Roni | Leininger, Brent | Shafto, Kate | Breen, Jenny | Sanaye, Mohammad R. | Daneshfard, Babak | Simões-Wüst, Ana P. | Moltó-Puigmartí, Carolina | van Dongen, Martien | Dagnelie, Pieter | Thijs, Carel | White, Shelley | Wiesener, Solveig | Salamonsen, Anita | Stub, Trine | Fønnebø, Vinjar | Abanades, Sergio | Blanco, Mar | Masllorens, Laia | Sala, Roser | Al-Ahnoumy, Shafekah | Han, Dongwoon | He, Luzhu | Kim, Ha Yun | In Choi, Da | Alræk, Terje | Stub, Trine | Kristoffersen, Agnete | von Sceidt, Christel | Michalsen, Andreas | Bruset, Stig | Musial, Frauke | Anheyer, Dennis | Cramer, Holger | Lauche, Romy | Saha, Felix J. | Dobos, Gustav | Anheyer, Dennis | Haller, Heidemarie | Lauche, Romy | Dobos, Gustav | Cramer, Holger | Azizi, Hoda | Khadem, Nayereh | Hassanzadeh, Malihe | Estiri, Nazanin | Azizi, Hamideh | Tavassoli, Fatemeh | Lotfalizadeh, Marzieh | Zabihi, Reza | Esmaily, Habibollah | Azizi, Hoda | Shabestari, Mahmoud Mohammadzadeh | Paeizi, Reza | Azari, Masoumeh Alvandi | Bahrami-Taghanaki, Hamidreza | Zabihi, Reza | Azizi, Hamideh | Esmaily, Habibollah | Baars, Erik | De Bruin, Anja | Ponstein, Anne | Baccetti, Sonia | Di Stefano, Mariella | Rossi, Elio | Firenzuoli, Fabio | Segantini, Sergio | Monechi, Maria Valeria | Voller, Fabio | Barth, Jürgen | Kern, Alexandra | Lüthi, Sebastian | Witt, Claudia | Barth, Jürgen | Zieger, Anja | Otto, Fabius | Witt, Claudia | Beccia, Ariel | Dunlap, Corina | Courneene, Brendan | Bedregal, Paula | Passi, Alvaro | Rodríguez, Alfredo | Chang, Mayling | Gutiérrez, Soledad | Beissner, Florian | Beissner, Florian | Preibisch, Christine | Schweizer-Arau, Annemarie | Popovici, Roxana | Meissner, Karin | Beljanski, Sylvie | Belland, Laura | Rivera-Reyes, Laura | Hwang, Ula | Berger, Bettina | Sethe, Dominik | Hilgard, Dörte | Heusser, Peter | Bishop, Felicity | Al-Abbadey, Miznah | Bradbury, Katherine | Carnes, Dawn | Dimitrov, Borislav | Fawkes, Carol | Foster, Jo | MacPherson, Hugh | Roberts, Lisa | Yardley, Lucy | Lewith, George | Bishop, Felicity | Al-Abbadey, Miznah | Bradbury, Katherine | Carnes, Dawn | Dimitrov, Borislav | Fawkes, Carol | Foster, Jo | MacPherson, Hugh | Roberts, Lisa | Yardley, Lucy | Lewith, George | Bishop, Felicity | Holmes, Michelle | Lewith, George | Yardley, Lucy | Little, Paul | Cooper, Cyrus | Bogani, Patrizia | Maggini, Valentina | Gallo, Eugenia | Miceli, Elisangela | Biffi, Sauro | Mengoni, Alessio | Fani, Renato | Firenzuoli, Fabio | Brands-Guendling, Nadine | Guendling, Peter W. | Bronfort, Gert | Evans, Roni | Haas, Mitch | Leininger, Brent | Schulz, Craig | Bu, Xiangwei | Wang, J. | Fang, T. | Shen, Z. | He, Y. | Zhang, X. | Zhang, Zhengju | Wang, Dali | Meng, Fengxian | Büssing, Arndt | Baumann, Klaus | Frick, Eckhard | Jacobs, Christoph | Büssing, Arndt | Grünther, Ralph-Achim | Lötzke, Désirée | Büssing, Arndt | Jung, Sonny | Lötzke, Désirée | Recchia, Daniela R. | Robens, Sibylle | Ostermann, Thomas | Berger, Bettina | Stankewitz, Josephin | Kröz, Matthias | Jeitler, Mika | Kessler, Christian | Michalsen, Andreas | Cheon, Chunhoo | Jang, Bo H. | Ko, Seong G. | Huang, Ching W. | Sasaki, Yui | Ko, Youme | Cheshire, Anna | Ridge, Damien | Hughes, John | Peters, David | Panagioti, Maria | Simon, Chantal | Lewith, George | Cho, Hyun J. | Han, Dongwoon | Choi, Soo J. | Jung, Young S. | Im, Hyea B | Cooley, Kieran | Tummon-Simmons, Laura | Cotton, Sian | Luberto, Christina M. | Wasson, Rachel | Kraemer, Kristen | Sears, Richard | Hueber, Carly | Derk, Gwendolyn | Lill, JR | An, Ruopeng | Steinberg, Lois | Rodriguez, Lourdes Diaz | la Fuente, Francisca García-de | De la Vega, Miguel | Vargas-Román, Keyla | Fernández-Ruiz, Jonatan | Cantarero-Villanueva, Irene | Rodriguez, Lourdes Diaz | García-De la Fuente, Francisca | Jiménez-Guerrero, Fanny | Vargas-Román, Keyla | Fernández-Ruiz, Jonatan | Galiano-Castillo, Noelia | Diaz-Saez, Gualberto | Torres-Jimenez, José I. | Garcia-Gomez, Olga | Hortal-Muñoz, Luis | Diaz-Diez, Camino | Dicen, Demijon | Diezel, Helene | Adams, Jon | Steel, Amie | Wardle, Jon | Diezel, Helene | Steel, Amie | Frawley, Jane | Wardle, Jon | Broom, Alex | Adams, Jon | Dong, Fei | Yu, He | Liu, Tiegang | Ma, Xueyan | Yan, Liyi | Wan, Yuxiang | Zheng, Zian | Gu, Xiaohong | Dong, Fei | Yu, He | Wu, Liqun | Liu, Tiegang | Ma, Xueyan | Ma, Jiaju | Yan, Liyi | Wan, Yuxiang | Zheng, Zian | Zhen, Jianhua | Gu, Xiaohong | Dubois, Julie | Rodondi, Pierre-Yves | Edelhäuser, Friedrich | Schwartze, Sophia | Trapp, Barbara | Cysarz, Dirk
PMCID: PMC5498855
12.  Ultralight, scalable, and high-temperature–resilient ceramic nanofiber sponges 
Science Advances  2017;3(6):e1603170.
Scalable synthesis of ultralight, multifunctional, and high-temperature resilient ceramic nanofiber sponges by blow-spinning.
Ultralight and resilient porous nanostructures have been fabricated in various material forms, including carbon, polymers, and metals. However, the development of ultralight and high-temperature resilient structures still remains extremely challenging. Ceramics exhibit good mechanical and chemical stability at high temperatures, but their brittleness and sensitivity to flaws significantly complicate the fabrication of resilient porous ceramic nanostructures. We report the manufacturing of large-scale, lightweight, high-temperature resilient, three-dimensional sponges based on a variety of oxide ceramic (for example, TiO2, ZrO2, yttria-stabilized ZrO2, and BaTiO3) nanofibers through an efficient solution blow-spinning process. The ceramic sponges consist of numerous tangled ceramic nanofibers, with densities varying from 8 to 40 mg/cm3. In situ uniaxial compression in a scanning electron microscope showed that the TiO2 nanofiber sponge exhibits high energy absorption (for example, dissipation of up to 29.6 mJ/cm3 in energy density at 50% strain) and recovers rapidly after compression in excess of 20% strain at both room temperature and 400°C. The sponge exhibits excellent resilience with residual strains of only ~1% at 800°C after 10 cycles of 10% compression strain and maintains good recoverability after compression at ~1300°C. We show that ceramic nanofiber sponges can serve multiple functions, such as elasticity-dependent electrical resistance, photocatalytic activity, and thermal insulation.
PMCID: PMC5457032
ultra-light materials; high-temperature resilience; nanofiber; blow-spinning
13.  Spatially-segmented undersampled MRI temperature reconstruction for transcranial MR-guided focused ultrasound 
Volumetric thermometry with fine spatiotemporal resolution is desirable to monitor MR-guided focused ultrasound (MRgFUS) procedures in the brain, but requires some form of accelerated imaging. Accelerated MR temperature imaging methods have been developed that undersample k-space and leverage signal correlations over time to suppress the resulting undersampling artifacts. However, in transcranial MRgFUS treatments, the water bath surrounding the skull creates signal variations that do not follow those correlations, leading to temperature errors in the brain due to signal aliasing.
To eliminate temperature errors due to the water bath, a spatially-segmented iterative reconstruction method was developed. The method fits a k-space hybrid signal model to reconstruct temperature changes in the brain, and a conventional MR signal model in the water bath. It was evaluated using single-channel 2DFT Cartesian, golden angle radial, and spiral data from gel phantom heating, and in vivo 8-channel 2DFT data from a FUS thalamotomy. Water bath signal intensity in phantom heating images was scaled between 0-100% to investigate its effect on temperature error. Temperature reconstructions of retrospectively undersampled data were performed using the spatially-segmented method, and compared to conventional whole-image k-space hybrid (phantom) and SENSE (in vivo) reconstructions.
At 100% water bath signal intensity, 3 ×-undersampled spatially-segmented temperature reconstruction error was nearly 5-fold lower than the whole-image k-space hybrid method. Temperature root-mean square error in the hot spot was reduced on average by 27 × (2DFT), 5 × (radial), and 12 × (spiral) using the proposed method. It reduced in vivo error 2 × in the brain for all acceleration factors, and between 2 × and 3 × in the temperature hot spot for 2-4 × undersampling compared to SENSE.
Separate reconstruction of brain and water bath signals enables accelerated MR temperature imaging during MRgFUS procedures with low errors due to undersampling using Cartesian and non-Cartesian trajectories. The spatially-segmented method benefits from multiple coils, and reconstructs temperature with lower error compared to measurements from SENSE-reconstructed images. The acceleration can be applied to increase volumetric coverage and spatiotemporal resolution.
PMCID: PMC5448150
Temperature imaging; Image reconstruction; Proton resonance frequency-shift; Thermometry; MRI-guided focused ultrasound
14.  Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administration of Meropenem in Patients with Severe Sepsis and Septic Shock: A Prospective Randomized Pilot Study 
Chinese Medical Journal  2017;130(10):1139-1145.
The antibiotic meropenem is commonly administered in patients with severe sepsis and septic shock. We compared the pharmacokinetic, clinical, and bacteriological efficacies of continuous infusion of meropenem versus intermittent administration in such patients.
Patients admitted to the Intensive Care Unit (ICU) with severe sepsis or septic shock who received meropenem were randomly assigned to either the continuous (n = 25) or intermittent groups (n = 25). The continuous group received a loading dose of 0.5 g of meropenem followed by a continuous infusion of 3 g/day; the intermittent group received an initial dose of 1.5 g followed by 1 g for every 8 h. Clinical success, microbiological eradication, superinfection, ICU mortality, length of ICU stay, and duration of meropenem treatment were assessed. Serial plasma meropenem concentrations for the first and third dosing periods (steady state) were also measured.
Clinical success was similar in both the continuous (64%) and intermittent (56%) groups (P = 0.564); the rates of microbiological eradication and superinfection (81.8% vs. 66.7% [P = 0.255] and 4% vs. 16% [P = 0.157], respectively) showed improvement in the continuous group. The duration of meropenem treatment was significantly shorter in the continuous group (7.6 vs. 9.4 days; P = 0.035), where a better steady-state concentration was also achieved. Peak and trough concentrations were significantly different between the continuous and intermittent groups both in the first (Cmax: 19.8 mg/L vs. 51.8 mg/L, P = 0.000; Cmin: 11.2 mg/L vs. 0.5 mg/L, P = 0.000) and third dosing periods (Cmax: 12.5 mg/L vs. 46.4 mg/L, P = 0.000; Cmin: 11.4 mg/L vs. 0.6 mg/L, P = 0.000). For medium-susceptibility pathogens, continuous infusion concentrations above the minimal inhibitory concentration were 100%, which was better than that in the intermittent group.
Continuous infusion of meropenem provides significantly shorter treatment duration and a tendency for superior bacteriological efficacy than intermittent administration. Continuous infusion may be more optimal against intermediate-susceptibility pathogens.
PMCID: PMC5443018  PMID: 28485312
Continuous Infusion; Intermittent Infusion; Meropenem; Pharmacodynamic; Pharmacokinetic
15.  Genomic and transcriptomic analyses reveal adaptation mechanisms of an Acidithiobacillus ferrivorans strain YL15 to alpine acid mine drainage 
PLoS ONE  2017;12(5):e0178008.
Acidithiobacillus ferrivorans is an acidophile that often occurs in low temperature acid mine drainage, e.g., that located at high altitude. Being able to inhabit the extreme environment, the bacterium must possess strategies to copy with the survival stress. Nonetheless, information on the strategies is in demand. Here, genomic and transcriptomic assays were performed to illuminate the adaptation mechanisms of an A. ferrivorans strain YL15, to the alpine acid mine drainage environment in Yulong copper mine in southwest China. Genomic analysis revealed that strain has a gene repertoire for metal-resistance, e.g., genes coding for the mer operon and a variety of transporters/efflux proteins, and for low pH adaptation, such as genes for hopanoid-synthesis and the sodium:proton antiporter. Genes for various DNA repair enzymes and synthesis of UV-absorbing mycosporine-like amino acids precursor indicated hypothetical UV radiation—resistance mechanisms in strain YL15. In addition, it has two types of the acquired immune system–type III-B and type I-F CRISPR/Cas modules against invasion of foreign genetic elements. RNA-seq based analysis uncovered that strain YL15 uses a set of mechanisms to adapt to low temperature. Genes involved in protein synthesis, transmembrane transport, energy metabolism and chemotaxis showed increased levels of RNA transcripts. Furthermore, a bacterioferritin Dps gene had higher RNA transcript counts at 6°C, possibly implicated in protecting DNA against oxidative stress at low temperature. The study represents the first to comprehensively unveil the adaptation mechanisms of an acidophilic bacterium to the acid mine drainage in alpine regions.
PMCID: PMC5438186  PMID: 28542527
16.  Direct and Accelerated Parameter Mapping Using the Unscented Kalman Filter 
Magnetic resonance in medicine  2015;75(5):1989-1999.
To accelerate parameter mapping using a new paradigm that combines image reconstruction and model regression as a parameter state-tracking problem.
In T2 mapping, the T2 map is first encoded in parameter space by multi-TE measurements and then encoded by Fourier transformation with readout/phase encoding gradients. Using a state transition function and a measurement function, the unscented Kalman filter can describe T2 mapping as a dynamic system and directly estimate the T2 map from the k-space data. The proposed method was validated with a numerical brain phantom and volunteer experiments with a multiple-contrast spin echo sequence. Its performance was compared to a conjugate-gradient nonlinear inversion method at undersampling factors of 2 to 8. An accelerated pulse sequence was developed based on this method to achieve prospective undersampling.
Compared to the nonlinear inversion reconstruction, the proposed method had higher precision, improved structural similarity and reduced normalized root mean squared error, with acceleration factors up to 8 in numerical phantom and volunteer studies.
This work describes a new perspective on parameter mapping by state tracking. The unscented Kalman filter provides a highly accelerated and efficient paradigm for T2 mapping.
PMCID: PMC4669238  PMID: 26040257
parameter mapping; p-space; accelerated imaging; unscented Kalman filter
17.  The effect of Timolol 0.5% on the correction of myopic regression after LASIK 
Medicine  2017;96(17):e6782.
Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect of Timolol 0.5% on the correction of myopic regression after LASIK.
This prospective, randomized, controlled study included 62 eyes of 62 patients with myopic regression of −1.18 ± 0.86 diopters (D) after myopic LASIK. They were randomly assigned into either Group 1 who received Timolol 0.5% eye drops for 3 months or Group 2 who received artificial tears as control (during treatment). Patients were followed an additional 2 months after cessation of eye drops treatment (posttreatment).
During treatment in Group 1, as the mean true intraocular pressure (IOPT) lowered significantly, regression stopped. As the mean IOPT increased significantly posttreatment and returned to its pretreatment level, regression recurred. The effective rate of Timolol therapy dropped from 62.5% during treatment to 40.6% posttreatment. On the contrary in Group 2, although the mean IOPT did not change significantly, regression continually happened as time passed. During treatment, the mean IOPT, uncorrected visual acuity, spherical equivalent (SE), and corneal refractive power showed significant difference between the 2 groups. In Group 1, the differences of effective rate of Timolol therapy between each of the 2 subgroups of age, gender, preoperative SE (PSE), or pretreatment time (how long we start treatment with Timolol post-LASIK) were not statistically significant.
IOP-lowering eye drop Timolol was effective for the correction of myopic regression when a 0.5-D or greater myopic shift is detected after LASIK in patients regardless of age, gender, PSE, or anytime we started the treatment only if regression happened. However, the myopic regression recurred after cessation of Timolol treatment.
PMCID: PMC5413280  PMID: 28445315
LASIK; myopic; Timolol
18.  A meta-analysis of PDE-gene polymorphism and cerebral infarction risk 
Previous studies identified that phosphodiesterase 4D (PDE4D) gene polymorphism might be associated with cerebral infarction or ischemic stroke, and hemorrhagic stroke in human populations. However, as yet, no meta-analysis has revealed any detailed association. We retrospectively reviewed studies regarding the relationship of PDE4D gene polymorphism with ischemic stroke (IS) published during the period January 2003 to September 2012. According to the inclusion criteria, 9 of 105 initial studies were included in the subsequent analysis. The PubMed, Embase and CNKI of China were searched to identify the relevant studies. A total of 186 young patients with IS were included for the meta-analysis and 232 matched control subjects were enrolled and results were presented. The association of PDE4D gene polymorphism with IS in various populations was examined. The results suggested that single nucleotide polymorphism (SNP), SNP 83 in PDE4D gene was significantly related with susceptibility to IS. The meta-analysis also showed that PDE4D gene was associated with an enhanced risk of IS. The meta-analysis suggested that PDE4D SNP 87 constitutes an independent risk factor for IS development. To the best of our knowledge, the present meta-analysis reveals a number of possible associations between PDE4D gene polymorphism and IS.
PMCID: PMC5450647
PDE-gene polymorphism; cerebral infarction; ischemic stroke; meta-analysis
19.  Patient characteristics and perceived health status of individuals with HIV and tuberculosis coinfection in Guangxi, China 
Medicine  2017;96(14):e6475.
To explore demographics, clinical and medication profiles, patients’ social support, and perceived health status in HIV/TB coinfected patients in Guangxi, China.
We performed a cross-sectional study in the HIV clinic of the Guigang City People's Hospital (N = 150). Health professionals conducted face-to-face interviews and collected data from patients’ electronic medical records regarding patients’ demographic, clinical, and medication information, as well as their social support and perceived health status. We classified all HIV/AIDS patients into HIV monoinfected and TB coinfected, at a ratio of 2:1.
Compared with the HIV monoinfected, patients with HIV/TB coinfection were more likely to be older, male, less educated, unemployed, carrying health insurance, having advanced stage of HIV infection, longer history with HIV, and other opportunistic infections. Patients coinfected with TB were also more likely to hold a negative belief that their HIV treatment could prevent exacerbations, and reported significantly worse emotional/informational support, social interaction, and perceived health status. Better social support and better self-efficacy to the HIV treatment adherence was significantly associated with better perceived health status among patients with HIV and TB coinfection.
Having HIV/TB coinfection was associated with poorer perceived general well-being and mental health, particularly in those undergoing TB therapy. Our findings suggest the need for mental health referrals and medication management for coinfected individuals, as well as further efforts and policies to improve coordinated care.
PMCID: PMC5411195  PMID: 28383411
clinical profile; HIV and tuberculosis coinfection; HIV treatment; HIV/TB coinfected; medication profile; perceived health; self-efficacy; social support
20.  Valence and magnitude ambiguity in feedback processing 
Brain and Behavior  2017;7(5):e00672.
Outcome feedback which indicates behavioral consequences are crucial for reinforcement learning and environmental adaptation. Nevertheless, outcome information in daily life is often totally or partially ambiguous. Studying how people interpret this kind of information would provide important knowledge about the human evaluative system.
This study concentrates on the neural processing of partially ambiguous feedback, that is, either its valence or magnitude is unknown to participants. To address this topic, we sequentially presented valence and magnitude information; electroencephalography (EEG) response to each kind of presentation was recorded and analyzed. The event‐related potential components feedback‐related negativity (FRN) and P3 were used as indices of neural activity.
Consistent with previous literature, the FRN elicited by ambiguous valence was not significantly different from that elicited by negative valence. On the other hand, the FRN elicited by ambiguous magnitude was larger than both the large and small magnitude, indicating the motivation to seek unambiguous magnitude information. The P3 elicited by ambiguous valence and ambiguous magnitude was not significantly different from that elicited by negative valence and small magnitude, respectively, indicating the emotional significance of feedback ambiguity. Finally, the aforementioned effects also manifested in the stage of information integration.
These findings indicate both similarities and discrepancies between the processing of valence ambiguity and that of magnitude ambiguity, which may help understand the mechanisms of ambiguous information processing.
PMCID: PMC5434181
ambiguous feedback; decision‐making; event‐related potential; feedback‐related negativity; P3
21.  Non-Cartesian Balanced SSFP Pulse Sequences for Real-Time Cardiac MRI 
Magnetic resonance in medicine  2015;75(4):1546-1555.
To develop a new spiral-in/out balanced steady-state free precession (bSSFP) pulse sequence for real-time cardiac MRI and compare it with radial and spiral-out techniques.
Non-Cartesian sampling strategies are efficient and robust to motion and thus have important advantages for real-time bSSFP cine imaging. This study describes a new symmetric spiral-in/out sequence with intrinsic gradient moment compensation and SSFP refocusing at TE=TR/2. In-vivo real-time cardiac imaging studies were performed to compare radial, spiral-out, and spiral-in/out bSSFP pulse sequences. Furthermore, phase-based fat-water separation taking advantage of the refocusing mechanism of the spiral-in/out bSSFP sequence was also studied.
The image quality of the spiral-out and spiral-in/out bSSFP sequences was improved with off-resonance and k-space trajectory correction. The spiral-in/out bSSFP sequence had the highest SNR, CNR, and image quality ratings, with spiral-out bSSFP sequence second in each category and the radial bSSFP sequence third. The spiral-in/out bSSFP sequence provides separated fat and water images with no additional scan time.
In this work a new spiral-in/out bSSFP sequence was developed and tested. The superiority of spiral bSSFP sequences over the radial bSSFP sequence in terms of SNR and reduced artifacts was demonstrated in real-time MRI of cardiac function without image acceleration.
PMCID: PMC4637255  PMID: 25960254
spiral; spiral-in/out; bSSFP; real-time cardiac imaging; fat-water separation
22.  International Society for Therapeutic Ultrasound Conference 2016 
Fowlkes, Brian | Ghanouni, Pejman | Sanghvi, Narendra | Coussios, Constantin | Lyon, Paul C. | Gray, Michael | Mannaris, Christophoros | Victor, Marie de Saint | Stride, Eleanor | Cleveland, Robin | Carlisle, Robert | Wu, Feng | Middleton, Mark | Gleeson, Fergus | Aubry, Jean-Franҫois | Pauly, Kim Butts | Moonen, Chrit | Vortman, Jacob | Ghanouni, Pejman | Sharabi, Shirley | Daniels, Dianne | Last, David | Guez, David | Levy, Yoav | Volovick, Alexander | Grinfeld, Javier | Rachmilevich, Itay | Amar, Talia | Zibly, Zion | Mardor, Yael | Harnof, Sagi | Plaksin, Michael | Weissler, Yoni | Shoham, Shy | Kimmel, Eitan | Naor, Omer | Farah, Nairouz | Shoham, Shy | Paeng, Dong-Guk | Xu, Zhiyuan | Snell, John | Quigg, Anders H. | Eames, Matthew | Jin, Changzhu | Everstine, Ashli C. | Sheehan, Jason P. | Lopes, Beatriz S. | Kassell, Neal | Looi, Thomas | Khokhlova, Vera | Mougenot, Charles | Hynynen, Kullervo | Drake, James | Slayton, Michael | Amodei, Richard C. | Compton, Keegan | McNelly, Ashley | Latt, Daniel | Slayton, Michael | Amodei, Richard C. | Compton, Keegan | Kearney, John | Melodelima, David | Dupre, Aurelien | Chen, Yao | Perol, David | Vincenot, Jeremy | Chapelon, Jean-Yves | Rivoire, Michel | Guo, Wei | Ren, Guoxin | Shen, Guofeng | Neidrauer, Michael | Zubkov, Leonid | Weingarten, Michael S. | Margolis, David J. | Lewin, Peter A. | McDannold, Nathan | Sutton, Jonathan | Vykhodtseva, Natalia | Livingstone, Margaret | Kobus, Thiele | Zhang, Yong-Zhi | Vykhodtseva, Natalia | McDannold, Nathan | Schwartz, Michael | Huang, Yuexi | Lipsman, Nir | Jain, Jennifer | Chapman, Martin | Sankar, Tejas | Lozano, Andres | Hynynen, Kullervo | Schwartz, Michael | Yeung, Robert | Huang, Yuexi | Lipsman, Nir | Jain, Jennifer | Chapman, Martin | Lozano, Andres | Hynynen, Kullervo | Damianou, Christakis | Papadopoulos, Nikolaos | Volovick, Alexander | Grinfeld, Javier | Levy, Yoav | Brokman, Omer | Zadicario, Eyal | Brenner, Ori | Castel, David | Wu, Shih-Ying | Grondin, Julien | Zheng, Wenlan | Heidmann, Marc | Karakatsani, Maria Eleni | Sánchez, Carlos J. Sierra | Ferrera, Vincent | Konofagou, Elisa E. | Damianou, Christakis | Yiannakou, Marinos | Cho, HongSeok | Lee, Hwayoun | Han, Mun | Choi, Jong-Ryul | Lee, Taekwan | Ahn, Sanghyun | Chang, Yongmin | Park, Juyoung | Ellens, Nicholas | Partanen, Ari | Farahani, Keyvan | Airan, Raag | Carpentier, Alexandre | Canney, Michael | Vignot, Alexandre | Lafon, Cyril | Chapelon, Jean-Yves | Delattre, Jean-yves | Idbaih, Ahmed | Odéen, Henrik | Bolster, Bradley | Jeong, Eun Kee | Parker, Dennis L. | Gaur, Pooja | Feng, Xue | Fielden, Samuel | Meyer, Craig | Werner, Beat | Grissom, William | Marx, Michael | Ghanouni, Pejman | Pauly, Kim Butts | Weber, Hans | Taviani, Valentina | Pauly, Kim Butts | Ghanouni, Pejman | Hargreaves, Brian | Tanaka, Jun | Kikuchi, Kentaro | Ishijima, Ayumu | Azuma, Takashi | Minamihata, Kosuke | Yamaguchi, Satoshi | Nagamune, Teruyuki | Sakuma, Ichiro | Takagi, Shu | Santin, Mathieu D. | Marsac, Laurent | Maimbourg, Guillaume | Monfort, Morgane | Larrat, Benoit | François, Chantal | Lehéricy, Stéphane | Tanter, Mickael | Aubry, Jean-Franҫois | Karakatsani, Maria Eleni | Samiotaki, Gesthimani | Wang, Shutao | Acosta, Camilo | Feinberg, Eliza R. | Konofagou, Elisa E. | Kovacs, Zsofia I. | Tu, Tsang-Wei | Papadakis, Georgios Z. | Reid, William C. | Hammoud, Dima A. | Frank, Joseph A. | Kovacs, Zsofia i. | Kim, Saejeong | Jikaria, Neekita | Bresler, Michele | Qureshi, Farhan | Frank, Joseph A. | Xia, Jingjing | Tsui, Po-Shiang | Liu, Hao-Li | Plata, Juan C. | Fielden, Samuel | Sveinsson, Bragi | Hargreaves, Brian | Meyer, Craig | Pauly, Kim Butts | Plata, Juan C. | Salgaonkar, Vasant A. | Adams, Matthew | Diederich, Chris | Ozhinsky, Eugene | Bucknor, Matthew D. | Rieke, Viola | Partanen, Ari | Mikhail, Andrew | Severance, Lauren | Negussie, Ayele H. | Wood, Bradford | de Greef, Martijn | Schubert, Gerald | Moonen, Chrit | Ries, Mario | Poorman, Megan E. | Dockery, Mary | Chaplin, Vandiver | Dudzinski, Stephanie O. | Spears, Ryan | Caskey, Charles | Giorgio, Todd | Grissom, William | Costa, Marcia M. | Papaevangelou, Efthymia | Shah, Anant | Rivens, Ian | Box, Carol | Bamber, Jeff | ter Haar, Gail | Burks, Scott R. | Nagle, Matthew | Nguyen, Ben | Bresler, Michele | Frank, Joseph A. | Burks, Scott R. | Nagle, Matthew | Nguyen, Ben | Bresler, Michele | Kim, Saejeong | Milo, Blerta | Frank, Joseph A. | Le, Nhan M. | Song, Shaozhen | Zhou, Kanheng | Nabi, Ghulam | Huang, Zhihong | Ben-Ezra, Shmuel | Rosen, Shani | Mihcin, Senay | Strehlow, Jan | Karakitsios, Ioannis | Le, Nhan | Schwenke, Michael | Demedts, Daniel | Prentice, Paul | Haase, Sabrina | Preusser, Tobias | Melzer, Andreas | Mestas, Jean-Louis | Chettab, Kamel | Gomez, Gustavo Stadthagen | Dumontet, Charles | Werle, Bettina | Lafon, Cyril | Marquet, Fabrice | Bour, Pierre | Vaillant, Fanny | Amraoui, Sana | Dubois, Rémi | Ritter, Philippe | Haïssaguerre, Michel | Hocini, Mélèze | Bernus, Olivier | Quesson, Bruno | Livneh, Amit | Kimmel, Eitan | Adam, Dan | Robin, Justine | Arnal, Bastien | Fink, Mathias | Tanter, Mickael | Pernot, Mathieu | Khokhlova, Tatiana D. | Schade, George R. | Wang, Yak-Nam | Kreider, Wayne | Simon, Julianna | Starr, Frank | Karzova, Maria | Maxwell, Adam | Bailey, Michael R. | Khokhlova, Vera | Lundt, Jonathan E. | Allen, Steven P. | Sukovich, Jonathan R. | Hall, Timothy | Xu, Zhen | Schade, George R. | Wang, Yak-Nam | Khokhlova, Tatiana D. | May, Philip | Lin, Daniel W. | Bailey, Michael R. | Khokhlova, Vera | Constans, Charlotte | Deffieux, Thomas | Tanter, Mickael | Aubry, Jean-Francois | Park, Eun-Joo | Ahn, Yun Deok | Kang, Soo Yeon | Park, Dong-Hyuk | Lee, Jae Young | Vidal-Jove, J. | Perich, E. | Ruiz, A. | Jaen, A. | Eres, N. | del Castillo, M. Alvarez | Myers, Rachel | Kwan, James | Coviello, Christian | Rowe, Cliff | Crake, Calum | Finn, Sean | Jackson, Edward | Carlisle, Robert | Coussios, Constantin | Pouliopoulos, Antonios | Li, Caiqin | Tinguely, Marc | Tang, Meng-Xing | Garbin, Valeria | Choi, James J. | Lyon, Paul C. | Mannaris, Christophoros | Gray, Michael | Folkes, Lisa | Stratford, Michael | Carlisle, Robert | Wu, Feng | Middleton, Mark | Gleeson, Fergus | Coussios, Constantin | Nwokeoha, Sandra | Carlisle, Robert | Cleveland, Robin | Wang, Yak-Nam | Khokhlova, Tatiana D. | Li, Tong | Farr, Navid | D’Andrea, Samantha | Starr, Frank | Gravelle, Kayla | Chen, Hong | Partanen, Ari | Lee, Donghoon | Hwang, Joo Ha | Tardoski, Sophie | Ngo, Jacqueline | Gineyts, Evelyne | Roux, Jean-Pau | Clézardin, Philippe | Melodelima, David | Conti, Allegra | Magnin, Rémi | Gerstenmayer, Matthieu | Lux, François | Tillement, Olivier | Mériaux, Sébastien | Penna, Stefania Della | Romani, Gian Luca | Dumont, Erik | Larrat, Benoit | Sun, Tao | Power, Chanikarn | Zhang, Yong-Zhi | Sutton, Jonathan | Miller, Eric | McDannold, Nathan | Sapozhnikov, Oleg | Tsysar, Sergey | Yuldashev, Petr V. | Khokhlova, Vera | Svet, Victor | Kreider, Wayne | Li, Dongli | Pellegrino, Antonio | Petrinic, Nik | Siviour, Clive | Jerusalem, Antoine | Cleveland, Robin | Yuldashev, Peter V. | Karzova, Maria | Cunitz, Bryan W. | Dunmire, Barbrina | Kreider, Wayne | Sapozhnikov, Oleg | Bailey, Michael R. | Khokhlova, Vera | Inserra, Claude | Guedra, Matthieu | Mauger, Cyril | Gilles, Bruno | Solovchuk, Maxim | Sheu, Tony W. H. | Thiriet, Marc | Zhou, Yufeng | Neufeld, Esra | Baumgartner, Christian | Payne, Davnah | Kyriakou, Adamos | Kuster, Niels | Xiao, Xu | McLeod, Helen | Melzer, Andreas | Dillon, Christopher | Rieke, Viola | Ghanouni, Pejman | Parker, Dennis L. | Payne, Allison | Khokhova, Vera A. | Yuldashev, Peter V. | Sinilshchikov, Ilya | Andriyakhina, Yulia | Khokhlova, Tatiana D. | Kreider, Wayne | Maxwell, Adam | Sapozhnikov, Oleg | Partanen, Ari | Rybyanets, Andrey | Shvetsova, Natalia | Berkovich, Alex | Shvetsov, Igor | Sapozhnikov, Oleg | Khokhlova, Vera | Shaw, Caroline J. | Rivens, Ian | Civale, John | Giussani, Dino | ter Haar, Gail | Lees, Christoph | Bour, Pierre | Marquet, Fabrice | Ozenne, Valery | Toupin, Solenn | Quesson, Bruno | Dumont, Erik | Ozhinsky, Eugene | Salgaonkar, Vasant | Diederich, Chris | Rieke, Viola | Kaye, Elena | Monette, Sebastien | Maybody, Majid | Srimathveeravalli, Govindarajan | Solomon, Stephen | Gulati, Amitabh | Preusser, Tobias | Haase, Sabrina | Bezzi, Mario | Jenne, Jürgen W. | Lango, Thomas | Levy, Yoav | Müller, Michael | Sat, Giora | Tanner, Christine | Zangos, Stephan | Günther, Matthias | Melzer, Andreas | Lafon, Cyril | Dinh, Au Hoang | Niaf, Emilie | Bratan, Flavie | Guillen, Nicolas | Souchon, Rémi | Lartizien, Carole | Crouzet, Sebastien | Rouviere, Olivier | Chapelon, Jean-Yves | Han, Yang | Wang, Shutao | Konofagou, Elisa E. | Payen, Thomas | Palermo, Carmine | Sastra, Steve | Chen, Hong | Han, Yang | Olive, Kenneth | Konofagou, Elisa E. | van Breugel, Johanna M. | de Greef, Martijn | Mougenot, Charles | van den Bosch, Maurice A. | Moonen, Chrit | Ries, Mario | Gerstenmayer, Matthieu | Magnin, Rémi | Fellah, Benjamin | Le Bihan, Denis | Larrat, Benoit | Gerstenmayer, Matthieu | Magnin, Rémi | Mériaux, Sébastien | Le Bihan, Denis | Larrat, Benoit | Allen, Steven P. | Hernandez-Garcia, Luis | Cain, Charles A. | Hall, Timothy | Lyka, Erasmia | Elbes, Delphine | Coviello, Christian | Cleveland, Robin | Coussios, Constantin | Zhou, Kanheng | Le, Nhan M. | Li, Chunhui | Huang, Zhihong | Tamano, Satoshi | Jimbo, Hayato | Azuma, Takashi | Yoshizawa, Shin | Fujiwara, Keisuke | Itani, Kazunori | Umemura, Shin-ichiro | Damianou, Christakis | Yiannakou, Marinos | Ellens, Nicholas | Partanen, Ari | Stoianovici, Dan | Farahani, Keyvan | Zaini, Zulfadhli | Takagi, Ryo | Yoshizawa, Shin | Umemura, Shin-ichiro | Zong, Shenyan | Shen, Guofeng | Watkins, Ron | Pascal-Tenorio, Aurea | Adams, Matthew | Plata, Juan C. | Salgaonkar, Vasant | Jones, Peter | Butts-Pauly, Kim | Diederich, Chris | Bouley, Donna | Rybyanets, Andrey | Ren, Guoxin | Guo, Wei | Shen, Guofeng | Chen, Yazhu | Lin, Chung-Yin | Hsieh, Han-Yi | Wei, Kuo-Chen | Liu, Hao-Li | Garnier, Camille | Renault, Gilles | Farr, Navid | Partanen, Ari | Negussie, Ayele H. | Mikhail, Andrew | Seifabadi, Reza | Wilson, Emmanuel | Eranki, Avinash | Kim, Peter | Wood, Bradford | Lübke, Dennis | Jenne, Jürgen W. | Huber, Peter | Günther, Matthias | Lübke, Dennis | Georgii, Joachim | Schwenke, Michael | Dresky, Caroline V. | Haller, Julian | Günther, Matthias | Preusser, Tobias | Jenne, Jürgen W. | Eranki, Avinash | Farr, Navid | Partanen, Ari | Yarmolenko, Pavel | Negussie, Ayele H. | Sharma, Karun | Celik, Haydar | Wood, Bradford | Kim, Peter | Li, Guofeng | Qiu, Weibao | Zheng, Hairong | Tsai, Meng-Yen | Chu, Po-Chun | Liu, Hao-Li | Webb, Taylor | Vyas, Urvi | Pauly, Kim Butts | Walker, Matthew | Zhong, Jidan | Looi, Thomas | Waspe, Adam C. | Drake, James | Hodaie, Mojgan | Yang, Feng-Yi | Huang, Sin-Luo | Zur, Yuval | Volovick, Alexander | Assif, Benny | Aurup, Christian | Kamimura, Hermes | Wang, Shutao | Chen, Hong | Acosta, Camilo | Carneiro, Antonio A. | Konofagou, Elisa E. | Volovick, Alexander | Grinfeld, Javier | Castel, David | Rothlübbers, Sven | Schwaab, Julia | Tanner, Christine | Mihcin, Senay | Houston, Graeme | Günther, Matthias | Jenne, Jürgen W. | Ozhinsky, Eugene | Bucknor, Matthew D. | Rieke, Viola | Azhari, Haim | Weiss, Noam | Sosna, Jacob | Goldberg, S. Nahum | Barrere, Victor | Melodelima, David | Jang, Kee W. | Burks, Scott R. | Kovacs, Zsofia I. | Tu, Tsang-Wei | Lewis, Bobbi | Kim, Saejeong | Nagle, Matthew | Jikaria, Neekita | Frank, Joseph A. | Zhou, Yufeng | Wang, Xiaotong | Ahn, Yun Deok | Park, Eun-Joo | Park, Dong-Hyuk | Kang, Soo Yeon | Lee, Jae Young | Suomi, Visa | Konofagou, Elisa E. | Edwards, David | Cleveland, Robin | Larrabee, Zahary | Eames, Matthew | Hananel, Arik | Aubry, Jean-Franҫois | Rafaely, Boaz | Volovick, Alexander | Grinfeld, Javier | Kimmel, Eitan | Debbiny, Rasha Elaimy | Dekel, Carmel Zeltser | Assa, Michael | Kimmel, Eitan | Menikou, George | Damianou, Christakis | Mouratidis, Petros | Rivens, Ian | ter Haar, Gail | Pineda-Pardo, José A. | de Pedro, Marta Del Álamo | Martinez, Raul | Hernandez, Frida | Casas, Silvia | Oliver, Carlos | Pastor, Patricia | Vela, Lidia | Obeso, Jose | Greillier, Paul | Zorgani, Ali | Souchon, Rémi | Melodelima, David | Catheline, Stefan | Lafon, Cyril | Solovov, Vyacheslav | Vozdvizhenskiy, Michael O. | Orlov, Andrew E. | Wu, Chueh-Hung | Sun, Ming-Kuan | Shih, Tiffany T. | Chen, Wen-Shiang | Prieur, Fabrice | Pillon, Arnaud | Mestas, Jean-Louis | Cartron, Valerie | Cebe, Patrick | Chansard, Nathalie | Lafond, Maxime | Lafon, Cyril | Inserra, Claude | Seya, Pauline Muleki | Chen, Wen-Shiang | Bera, Jean-Christophe | Boissenot, Tanguy | Larrat, Benoit | Fattal, Elias | Bordat, Alexandre | Chacun, Helene | Guetin, Claire | Tsapis, Nicolas | Maruyama, Kazuo | Unga, Johan | Suzuki, Ryo | Fant, Cécile | Lafond, Maxime | Rogez, Bernadette | Ngo, Jacqueline | Lafon, Cyril | Mestas, Jean-Louis | Afadzi, Mercy | Myhre, Ola Finneng | Vea, Siri | Bjørkøy, Astrid | Yemane, Petros Tesfamichael | van Wamel, Annemieke | Berg, Sigrid | Hansen, Rune | Angelsen, Bjørn | Davies, Catharina
Journal of Therapeutic Ultrasound  2017;5(Suppl 1):15.
PMCID: PMC5374646
23.  Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions 
Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot, in that human endometrial stem cells have been isolated from the endometrium. Three transcription factors that play key roles in maintaining pluripotency and self-renewal in stem cells are sex-determining region Y-box2 (SOX2), Nanog homebox (NANOG), and octamer-binding protein (OCT4), which may be responsible for the damage or repair process of uterine endometrium. We aim to investigate the expression of SOX2, NANOG and OCT4 in a mouse model of acute uterine injury induced by peritoneal injection of lipopolysaccharide (LPS) and also analyze their changes in endometrium of women with IUA.
The mouse uterine horns were collected at 0 h, 6 h, 12 h, 18 h or 24 h after a single dose of LPS or PBS injection. Meanwhile, we recruited 19 women with IUA diagnosed by hysteroscopy and 16 disease-free women as control group. Endometrial tissue samples were collected. SOX2, NANOG, and OCT4 expression were analyzed with Quantitative Real-time Polymerase Chain Reaction and Western blotting assay.
In a mouse model of acute uterine injury, there was significant upregulation of NANOG at 6 h, SOX2 and OCT4 at 12 h compared with the values before injection or PBS injection. NANOG expression reached a peak at 6 h, while SOX2 and OCT4 peaked later at 12 h after LPS treatment. NANOG mRNA and protein expressions were significantly higher in endometrium of IUA patients compared to those of the control group.
Expression of pluripotency factors SOX2, NANOG and OCT4 increased in a mouse model of LPS-induced acute uterine injury. NANOG peaked earlier followed by the other two factors before returning to baseline levels. NANOG but not SOX2 and OCT4 expression was overexpressed in the endometrium of women with IUA. They may be involved in the formation or restoration of IUA, and their roles in pathogenesis of IUA need to be further studied.
PMCID: PMC5335735  PMID: 28253866
Acute inflammation; Intrauterine adhesions; Sex-determining Y-box2; Nanog homebox; Octamer-binding protein
24.  Social hierarchy modulates neural responses of empathy for pain 
Recent evidence indicates that empathic responses to others’ pain are modulated by various situational and individual factors. However, few studies have examined how empathy and underlying brain functions are modulated by social hierarchies, which permeate human society with an enormous impact on social behavior and cognition. In this study, social hierarchies were established based on incidental skill in a perceptual task in which all participants were mediumly ranked. Afterwards, participants were scanned with functional magnetic resonance imaging while watching inferior-status or superior-status targets receiving painful or non-painful stimulation. The results revealed that painful stimulation applied to inferior-status targets induced higher activations in the anterior insula (AI) and anterior medial cingulate cortex (aMCC), whereas these empathic brain activations were significantly attenuated in response to superior-status targets’ pain. Further, this neural empathic bias to inferior-status targets was accompanied by stronger functional couplings of AI with brain regions important in emotional processing (i.e. thalamus) and cognitive control (i.e. middle frontal gyrus). Our findings indicate that emotional sharing with others’ pain is shaped by relative positions in a social hierarchy such that underlying empathic neural responses are biased toward inferior-status compared with superior-status individuals.
PMCID: PMC4769637  PMID: 26516169
social hierarchy; empathy; anterior insula (AI); anterior medial cingulate cortex (aMCC); Toronto Alexithymia Scale-20 Items (TAS-20); functional connectivity
25.  Impact of blue-light filtering intraocular lens implantation on the quality of sleep in patients after cataract surgery 
Medicine  2016;95(51):e5648.
There are 2 main types of intraocular lens (IOL) currently implanted in patients after cataract surgery. Till now, we do not know exactly what the effect of intraocular lens implantation will be on the quality of sleep after cataract surgery.
The binocular BF-IOL (BF-IOL Groups) and UVB-IOL (UVB-IOL Groups) implantations were performed in 60 and 59 cataract patients, respectively. Pittsburgh Sleep Quality Index (PSQI) questionnaires were administered to evaluate the quality of sleep in patients preoperatively, 1 month (1 m) and 12 months (12 m) postoperatively. Independent sample test and χ2 test were used to evaluate the difference between the 2 groups; one-way ANOVA was used to evaluate the difference preoperatively and postoperatively in each group. The rank sum test was used for statistical analysis of 7 independent sleep components in PSQI.
As compared to preoperatively, the PSQI overall scores in both groups improved significantly postoperatively (P = 0.00 at 1 m and 12 m). Among the 7 components of PSQI, 2 of them (sleep latency and daytime dysfunction) improved greatly postoperatively in both groups (P< 0.05). Although the improvement of PSQI overall score in the UVB-IOL group was greater than that in the BF-IOL Group only at early time (1 m) postoperatively (P = 0.00), but not late time (12 m, P > 0.05) after the cataract surgery.
The sleep quality of cataract patients improved after IOL implantation, regardless of the type of IOL, suggesting that BF-IOL might serve as an alternative to conventional UVB-IOL without a detrimental effect on quality of sleep after cataract surgery.
PMCID: PMC5181817  PMID: 28002333
blue-light filtering intraocular lens; cataract; circadian rhythm; quality of sleep

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