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On February 23, 2018, PubMed Central Canada (PMC Canada) will be taken offline permanently. No author manuscripts will be deleted, and the approximately 2,900 manuscripts authored by Canadian Institutes of Health Research (CIHR)-funded researchers currently in the archive will be copied to the National Research Council’s (NRC) Digital Repository over the coming months. These manuscripts along with all other content will also remain publicly searchable on PubMed Central (US) and Europe PubMed Central, meaning such manuscripts will continue to be compliant with the Tri-Agency Open Access Policy on Publications.

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1.  Multicentre prospective cohort study of body mass index and postoperative complications following gastrointestinal surgery 
Drake, T. M. | Nepogodiev, D. | Chapman, S. J. | Glasbey, J. C. | Khatri, C. | Kong, C. Y. | Claireaux, H. A. | Bath, M. F. | Mohan, M. | McNamee, L. | Kelly, M. | Mitchell, H. | Fitzgerald, J. E. | Harrison, E. M. | Bhangu, A. | Claireaux, H. A. | Antoniou, I. | Dean, R. | Davies, N. | Trecarten, S. | Henderson, I. | Holmes, C. | Wylie, J. | Shuttleworth, R. H. | Jindal, A. | Hughes, F. | Gouda, P. | McNamee, L. | Fleck, R. | Hanrahan, M. | Karunakaran, P. | Chen, J. H. | Sykes, M. C. | Sethi, R. K. | Suresh, S. | Patel, P. | Patel, M. | Varma, R. K. | Mushtaq, J. | Gundogan, B. | Bolton, W. | Mohan, M. | Khan, T. | Burke, J. | Morley, R. | Favero, N. | Adams, R. | Thirumal, V. | Kennedy, E. D. | Ong, K. K. | Tan, Y. H. | Gabriel, J. | Bakhsh, A. | Low, J. Y. L. | Yener, A. | Paraoan, V. | Preece, R. | Tilston, T. W. | Cumber, E. | Dean, S. | Ross, T. | McCance, E. | Amin, H. | Satterthwaite, L. | Clement, K. D. | Gratton, R. | Mills, E. D. | Chiu, S. M. | Hung, G. | Rafiq, N. M. | Hayes, J. D. B. | Robertson, K. L. | Dynes, K. | Huang, H. C. | Assadullah, S. | Duncumb, J. W. | Moon, R. D. C. | Poo, S. X. | Mehta, J. K. | Joshi, K. R. | Callan, R. | Norris, J. M. | Chilvers, N. J. | Keevil, H. | Jull, P. | Mallick, S. | Elf, D. | Carr, L. | Player, C. | Barton, E. C. | Martin, A. L. | Ratu, S. G. | Roberts, E. J. | Phan, P. N. | Dyal, A. R. | Rogers, J. E. | Henson, A. D. | Reid, N. B. | Burke, D. | Culleton, G. | Lynne, S. | Burke, D. | Mansoor, S. | Brennan, C. | Blessed, R. | Holloway, C. | Hill, A. | Goldsmith, T. | Mackin, S. | Kim, S. | Woin, E. | Brent, G. | Coffin, J. | Ziff, O. | Momoh, Z. | Debenham, R. | Ahmed, M. | Yong, C. S. | Wan, J. C. | Copley, H. C. | Raut, P. | Chaudhry, F. I. | Shuttleworth, R. H. | Nixon, G. | Dorman, C. | Tan, R. | Kanabar, S. | Canning, N. | Dolaghan, M. | Bell, N. | McMenamin, M. | Chhabra, A. | Duke, K. | Turner, L. | Patel, T. | Chew, L. S. | Mirza, M. | Lunawat, S. | Oremule, B. | Ward, N. | Khan, M. | Tan, E. T. | Maclennan, D. | McGregor, R. J. | Chisholm, E. G. | Griffin, E. J. | Bell, L. | Hughes, B. A. | Davies, J. | Haq, H. | Ahmed, H. | Ungcharoen, N. | Whacha, C. | Thethi, R. | Markham, R. M. | Lee, A. H. Y. | Batt, E. | Bullock, N. P. | Francescon, C. T. | Davies, J. E. | Shafiq, N.M. | Zhao, J. | Vivekanantham, S. | Barai, I. | Allen, J. L. Y. | Marshall, D. C. | McIntyre, C. J. | Wilson, H. C. P. | Ashton, A. J. | Lek, C. | Behar, N. | Davis‐Hall, M. | Seneviratne, N. | Kim, S. | Esteve, L. | Sirakaya, M. | Ali, S. | Pope, S. | Ahn, J. S. | Craig‐McQuaide, A. | Gatfield, W. A. | Leong, S. | Demetri, A. M. | Kerr, A. L. | Rees, C. | Loveday, J. | Liu, S. | Wijesekera, M. | Maru, D. | Attalla, M. | Smith, N. | Brown, D. | Sritharan, P. | Shah, A. | Charavanamuttu, V. | Heppenstall‐Harris, G. | Ng, K. | Raghvani, T. | Rajan, N. | Hulley, K. | Moody, N. | Williams, M. | Cotton, A. | Sharifpour, M. | Lwin, K. N. | Bright, M. | Chitnis, A. R. | Abdelhadi, M. | Semana, A. D. | Morgan, F. | Reid, R. | Dickson, J. | Anderson, L. | McMullan, R. | Dickson, J. | Ahern, N. | Asmadi, A. | Anderson, L. B. | Lua Boon Xuan, J. | Crozier, L. | McAleer, S. | Lees, D. M. | Adebayo, A. A. | Das, M. | Amphlett, A. H. | Al‐Robeye, A. | Valli, A. | Khangura, J. | Winarski, A. | Ali, A. | Khangura, J. | Woodward, H. | Gouldthrope, C. | Turner, M. | Sasapu, K. | Tonkins, M. | Wild, J. R. L. | Robinson, M. | Hardie, J. | Heminway, R. | Narramore, R. | Ramjeeawon, N. | Hibberd, A. | Winslow, F. | Ho, W. | Chong, B. F. | Lim, K. | Ho, S. | Crewdson, J. A. | Singagireson, S. | Kalra, N. | Koumpa, F. | Jhala, H. | Soon, W. C. | Karia, M. | Rasiah, M. G. | Xylas, D. | Gilbert, H. | Sundar‐Singh, M. | Wills, J. | Mushtaq, J. | Akhtar, S. | Patel, S. | Hu, L. | Brathwaite‐Shirley, C. | Nayee, H. | Amin, O. | Rangan, T. | Turner, E. J. H. | McCrann, C. | Shepherd, R. | Patel, N. | Prest‐Smith, J. | Auyoung, E. | Murtaza, A. | Coates, A. | Prys‐Jones, O. | King, M. | Gaffney, S. | Dewdney, C. J. | Nehikhare, I. | Lavery, J. | Bassett, J. | Davies, K. | Ahmad, K. | Collins, A. | Acres, M. | Egerton, C. | Khan, T. | Cheng, K. | Chen, X. | Chan, N. | Sheldon, A. | Khan, S. | Empey, J. | Ingram, E. | Malik, A. | Johnstone, M. | Goodier, R. | Shah, J. P. | Giles, J. E. | Sanders, J. A. | McLure, S. W. | Pal, S. | Rangedara, A. | Baker, A. N. | Asbjoernsen, C. A. | Girling, C. | Gray, L. | Gauntlett, L. | Joyner, C. | Qureshi, S. | Dean, S. | Mogan, Y. P. | Ng, J. C. K. | Kumar, A. N. | Park, J. H. | Tan, D. | Choo, K. P. | Raman, K. P. | Buakuma, P. | Xiao, C. | Govinden, S. | Thompson, O. D. | Charalambos, M. A. | Brown, E. | Karsan, R. B. | Dogra, T. | Bullman, L. M. | Dawson, P. M. | Frank, A. L. | Abid, H. | Tung, L. | Qureshi, U. | Tahmina, A. | Matthews, B. W. | Harris, R. T. | O'Connor, A. | Mazan, K. | Iqbal, S. | Stanger, S. A. | Thompson, J. D. | Sullivan, J. A. L. | Uppal, E. | MacAskill, A. | Bamgbose, F. A. | Neophytou, C. | Carroll, A. F. | Rookes, C. W. | Datta, U. | Dhutia, A. J. | Rashid, S. | Ahmed, N. | Lo, T. | Bhanderi, S. | Blore, C. D. | Ahmed, S. | Shaheen, H. | Abburu, S. | Majid, S. | Abbas, Z. | Talukdar, S. S. | Ahmed, S. | Burney, L. J. | Patel, J. B. | Al‐Obaedi, O. | Roberts, A. W. | Al‐Obaedi, O. | Mahboob, S. | Singh, B. | Sheth, S. | Karia, P. | Prabhudesai, A. | Kow, K. | Koysombat, K. | Wang, S. | Morrison, P. | Maheswaran, Y. | Keane, P. | Copley, P. C. | Brewster, O. | Xu, G. X. | Harries, P. | Wall, C. | Al‐Mousawi, A. | Bonsu, S. | Cunha, P. | Ward, T. | Paul, J. | Nadanakumaran, K. | Tayeh, S. | Ward, T. | Holyoak, H. | Remedios, J. | Theodoropoulou, K. | Ward, T. | Luhishi, A. | Jacob, L. | Long, F. | Atayi, A. | Sarwar, S. | Parker, O. | Harvey, J. | Ross, H. | Rampal, R. | Thomas, G. | Vanmali, P. | McGowan, C. | Stein, J. | Robertson, V. | Carthew, L. | Teng, V. | Fong, J. | Street, A. N. | Thakker, C. E. | O'Reilly, D. | Bravo, M. | Pizzolato, A. | Khokhar, H. A. | Ryan, M. | Cheskes, L. | Carr, R. | Salih, A. E. | Bassiony, S. | Yuen, R. | Chrastek, D. | Rosen O'Sullivan, H. | Amajuoyi, A. | Wang, A. | Sitta, O. | Wye, J. | Qamar, M. A. | Major, C. | Kaushal, A. | Morgan, C. | Petrarca, M. | Allot, R. | Verma, K. | Dutt, S. | Allot, R. | Chilima, C. P. | Peroos, S. | Allot, R. | Kosasih, S. R. | Chin, H. | Ashken, L. | Pearse, R. J. | O'Loughlin, R. A. | Menon, A. | Singh, K. | Norton, J. | Sagar, R. | Jathanna, N. | Rothwell, L. | Watson, N. | Harding, F. | Dube, P. | Khalid, H. | Punjabi, N. | Sagmeister, M. | Gill, P. | Shahid, S. | Hudson‐Phillips, S. | George, D. | Ashwood, J. | Lewis, T. | Dhar, M. | Sangal, P. | Rhema, I. A. | Kotecha, D. | Dean, R. | Afzal, Z. | Syeed, J. A. | Prakash, E. | Jalota, P. | Dean, R. | Herron, J. | Kimani, L. | Delport, A. | Shukla, A. | Agarwal, V. | Parthiban, S. | Thakur, H. | Cymes, W. | Rinkoff, S. | Turnbull, J. A. | Hayat, M. | Darr, S. | Khan, U. | Lim, J. | Higgins, A. | Lakshmipathy, G. | Forte, B. | Canning, E. | Jaitley, A. | Lamont, J. | Toner, E. | Ghaffar, A. | McDowell, M. | Salmon, D. | Gouda, P. | O'Carroll, O. | Khan, A. | Kelly, M. E. | Clesham, K. | Palmer, C. | Lyons, R. | Kelly, M. E. | Bell, A. | Chin, R. | Waldron, R. M. | Kelly, M. E. | Trimble, A. | Cox, S. E. | Ashfaq, U. | Campbell, J. | Holliday, R. B. S. | McCabe, G. | Morris, F. | Priestland, R. | Dean, S. | Vernon, O. K. | Ledsam, A. | Vaughan, R. | Lim, D. | Bakewell, Z. R. | Hughes, R. K. | Koshy, R. M. | Jackson, H. R. | Narayan, P. | Cardwell, A. E. | Jubainville, C. L. | Arif, T. | Elliott, L. E. | Gupta, V. | Arif, T. | Bhaskaran, G. | Singh, K. | Odeleye, A. | Ahmed, F. | Shah, R. | Odeleye, A. | Pickard, J. | Suleman, Y. N. | Odeleye, A. | North, A. S. | McClymont, L. F. | Hussain, N. | Ibrahim, I. | Ng, G. S. | Wong, V. | Lim, A. E. | Harris, L. N. | Tharmachandirar, T. | Mittapalli, D. | Patel, V. | Lakhani, M. | Davies, N. | Bazeer, H. Z. | Narwani, V. | Sandhu, K. K. | Wingfield, L. R. | Gentry, S. | Adjei, H. | Bhatti, M. | Braganza, L. | Barnes, J. | Mistry, S. | Chillarge, G. | Stokes, S. | Cleere, J. | Wadanamby, S. | Bucko, A. M. | Meek, J. | Boxall, N. | Heywood, E. G. | Wiltshire, J. J. | Toh, C. | Ward, A. E. | Shurovi, B. N. | Drake, T. M. | Horth, D. | Patel, B. Y. | Ali, B. | Spencer, T. | Axelson, T. | Kretzmer, L. | Chhina, C. | Anandarajah, C. | Fautz, T. | Horst, C. | Thevathasan, A. A. | Ng, J. Q. | Hirst, F. | Brewer, C. F. | Logan, A. E. | Lockey, J. W. | Forrest, P. R. | Keelty, N. | Wood, A. D. | Springford, L. R. | Avery, P. | Schulz, T. M. | Bemand, T. P. | Howells, L. | Collier, H. | Khajuria, A. | Tharakan, R. G. | Parsons, S. | Buchan, A. M. | McGalliard, R. J. | Mason, J. D. | Cundy, O. J. | Li, N. | Redgrave, N. A. | Watson, R. P. | Pezas, T. P. | Dennis, Y. F. | Segall, E. | Hameed, M. | Lynch, A. S. | Chamberlain, M. | Peck, F. S. | Neo, Y. N. | Russell, G. | Elseedawy, M. | Lee, S. | Foster, N. L. | Soo, Y. H. | Puan, L. | Dennis, R. | Goradia, H. | Qureshi, A. | Osman, S. | Reeves, T. | Dinsmore, L. | Marsden, M. | Lu, Q. | Pitts‐Tucker, T. | Dunn, C. E. | Walford, R. A. | Heathcote, E. | Martin, R. | Pericleous, A. | Brzyska, K. | Reid, K. G. | Williams, M. R. | Wetherall, N. | McAleer, E. | Thomas, D. | Kiff, R. | Gouldthrope, C. | Milne, S. | Holmes, M. J. V. | Stokes, S. | Bartlett, J. | de Carvalho, J. Lucas | Bloomfield, T. | Tongo, F. | Bremner, R. H. | Yong, N. | Atraszkiewicz, B. A. | Mehdi, A. | Tahir, M. | Sherliker, G. X. J. | Tear, A. K. | Pandey, A. | Broyd, A. | Omer, H. M. | Raphael, M. | Chaudhry, W. W. | Shahidi, S. | Jawad, A. S. | Gill, C. K. | Hindle Fisher, I. | Adeleja, I. | Clark, I. J. | Aidoo‐Micah, G. E. | Stather, P. W. | Salam, G. J. | Glover, T. E. | Deas, G. | Sim, N. K. | Obute, R. D. | Wynell‐Mayow, W. M. | Sait, M. S. | Mitha, N. | de Bernier, G. L. | Siddiqui, M. | Shaunak, R. | Wali, A. | Cuthbert, G. | Bhudia, R. | Webb, E. | Shah, S. | Ansari, N. | Perera, M. | Kelly, N. | McAllister, R. | Stanley, G. H. | Keane, C. P. | Shatkar, V. | Maxwell‐Armstrong, C. | Henderson, L. A. | Maple, N. | Manson, R. | Adams, R. D. | Brown, E. | Semple, E. | Mills, M. | Daoub, A. | Marsh, A. | Ramnarine, A. | Hartley, J. | Malaj, M. | Jewell, P. D. | Whatling, E. A. | Hitchen, N. | Chen, M. | Goh, B. | Fern, J. | Rogers, S. | Derbyshire, L. | Robertson, D. T. | Abuhussein, N. | Deekonda, P. | Abid, A. | Bakhsh, A. | Harrison, P. L. M. | Aildasani, L. | Turley, H. | Sherif, M. A. | Pandey, G. | Filby, J. J. | Johnston, A. | Burke, E. | Mohamud, M. | Gohil, K. | Tsui, A. Y. | Singh, R. | Lim, S. J. | O'Sullivan, K. | McKelvey, L. L. | O'Neill, S. | Roberts, H. F. | Brown, F. S. | Cao, Y. | Buckle, R. T. | Liew, Y. | Sii, S. | Ventre, C. M. | Graham, C. J. | Filipescu, T. | Yousif, A. | Dawar, R. | Wright, A. | Peters, M. | Varley, R. | Owczarek, S. | Hartley, S. | Khattak, M. | Iqbal, A. | Ali, M. | Durrani, B. | Narang, Y. | Bethell, G. S. | Horne, L. | Pinto, R. | Nicholls, K. | Kisyov, I. | Torrance, H. D. | Patel, P. | Patel, M. | English, W. | Lakhani, S. M. | Ashraf, S. F. | Venn, M. | Elangovan, V. | Kazmi, Z. | Brecher, J. | Sukumar, S. | Mastan, A. | Mortimer, A. | Parker, J. | Boyle, J. | Elkawafi, M. | Beckett, J. | Mohite, A. | Narain, A. | Mazumdar, E. | Sreh, A. | Hague, A. | Weinberg, D. | Fletcher, L. | Steel, M. | Shufflebotham, H. | Masood, M. | Sinha, Y. | Amin, H. | Jenvey, C. | Kitt, H. | Slade, R. | Craig, A. R. | Deall, C. | Sinha, Y. | Gabriel, J. | Reakes, T. | Chervenkoff, J. | Strange, E. | O'Bryan, M. | Murkin, C. | Joshi, D. | Strange, E. | Bergara, T. | Naqib, S. | Wylam, D. | Strange, E. | Scotcher, S. E. | Hewitt, C. M. | Stoddart, M. T. | Kerai, A. | Trist, A. J. | Cole, S. J. | Knight, C. L. | Stevens, S. | Cooper, G. E. | Ingham, R. | Dobson, J. | Wylie, J. | O'Kane, A. | Moradzadeh, J. | Duffy, A. | Henderson, C. | Ashraf, S. | McLaughin, C. | Hoskins, T. C. | Reehal, R. S. | Bookless, L. R. | McLean, R. C. | Stone, E. J. | Wright, E. V. | Abdikadir, H. 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The British Journal of Surgery  2016;103(9):1157-1172.
Background
There is currently conflicting evidence surrounding the effects of obesity on postoperative outcomes. Previous studies have found obesity to be associated with adverse events, but others have found no association. The aim of this study was to determine whether increasing body mass index (BMI) is an independent risk factor for development of major postoperative complications.
Methods
This was a multicentre prospective cohort study across the UK and Republic of Ireland. Consecutive patients undergoing elective or emergency gastrointestinal surgery over a 4‐month interval (October–December 2014) were eligible for inclusion. The primary outcome was the 30‐day major complication rate (Clavien–Dindo grade III–V). BMI was grouped according to the World Health Organization classification. Multilevel logistic regression models were used to adjust for patient, operative and hospital‐level effects, creating odds ratios (ORs) and 95 per cent confidence intervals (c.i.).
Results
Of 7965 patients, 2545 (32·0 per cent) were of normal weight, 2673 (33·6 per cent) were overweight and 2747 (34·5 per cent) were obese. Overall, 4925 (61·8 per cent) underwent elective and 3038 (38·1 per cent) emergency operations. The 30‐day major complication rate was 11·4 per cent (908 of 7965). In adjusted models, a significant interaction was found between BMI and diagnosis, with an association seen between BMI and major complications for patients with malignancy (overweight: OR 1·59, 95 per cent c.i. 1·12 to 2·29, P = 0·008; obese: OR 1·91, 1·31 to 2·83, P = 0·002; compared with normal weight) but not benign disease (overweight: OR 0·89, 0·71 to 1·12, P = 0·329; obese: OR 0·84, 0·66 to 1·06, P = 0·147).
Conclusion
Overweight and obese patients undergoing surgery for gastrointestinal malignancy are at increased risk of major postoperative complications compared with those of normal weight.
High BMI increases risk of complications
doi:10.1002/bjs.10203
PMCID: PMC4973675  PMID: 27321766
3.  ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression 
Scientific Reports  2017;7:45.
Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mesenchymal transition (EMT), a critical cellular event for metastasis of malignant tumors of epithelium origin. ZEB1 is also expressed in UM and high expression of ZEB1 correlates with UM advancement, but has little effect on cell morphology. We show that spindle UM cells can become epithelioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dedifferentiation, proliferation, invasiveness, and dissemination. We provide evidence that ZEB1 binds not only to repress critical genes involving in pigment synthesis, mitosis, adherent junctions, but also to transactivate genes involving in matrix degradation and cellular locomotion to propel UM progression towards metastasis. We conclude that ZEB1 is a major oncogenic factor required for UM progression and could be a potential therapeutic target for treating UM in the clinic.
doi:10.1038/s41598-017-00079-x
PMCID: PMC5428321  PMID: 28246385
4.  Isolated presumed optic nerve gumma, a rare presentation of neurosyphilis 
Purpose
The incidence of syphilitic infections continues to rise and represents a major public health concern, particularly in patients co-infected with human immunodeficiency virus (HIV). The infection has a multitude of clinical presentations and is often referred to as the ‘great imitator.’ We present a rare case of an isolated presumed syphilitic optic nerve gumma and characterize it using newer imaging modalities.
Observations
A 36-year-old HIV-positive man, compliant with treatment, presented with a five day history of decreased vision in the left eye. On examination his visual acuity was 20/30 with mild dyschromatopsia and an inferior altitudinal field defect in the left eye. Funduscopy demonstrated small cup to disc ratios bilaterally and a swollen and hyperemic left optic disc. Following five months of stable vision, the patient's vision in the left eye declined to 20/60, associated with diffuse visual field loss and continued swelling of the left optic disc. Subsequent magnetic resonance imaging with contrast demonstrated enhancement of the left optic nerve, and his serologies were positive for syphilis. Fluorescein angiography and optical coherence tomography were used to better characterize the lesion being most consistent with a syphilitic optic nerve gumma.
Conclusions and importance
Gummas of the central nervous system are a rare presentation of neurosyphilis and the last reported gumma of the optic nerve was in 1990. Such lesions have not been characterized using newer imaging modalities including optical coherence tomography and fluorescein angiography, both of which may assist in the diagnosis of this rare entity. With the increased prevalence of syphilis and remarkable response to therapy, syphilitic gummas should be considered in at-risk patients presenting with an optic neuropathy.
doi:10.1016/j.ajoc.2017.01.003
PMCID: PMC5722128
Syphilis optic neuropathy
5.  Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine 
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Critical Care  2016;20:347.
doi:10.1186/s13054-016-1358-6
PMCID: PMC5078922
6.  36th International Symposium on Intensive Care and Emergency Medicine 
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Critical Care  2016;20(Suppl 2):94.
Table of contents
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux
R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis
P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu.
J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego
P003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsis
F. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. Tuzun
P004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopenia
R. Riff, O. Naamani, A. Douvdevani
P005 - Analysis of neutrophil by hyper spectral imaging - A preliminary report
R. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. Shimazu
P006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgery
S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda
P007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational study
T. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. Shimazu
P008 - Comparison of bacteremia and sepsis on sepsis related biomarkers
T. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. Ono
P009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purification
T. Taniguchi, M. O
P010 - Validation of a new sensitive point of care device for rapid measurement of procalcitonin
C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott
P011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive protein
M. M. Meili, P. S. Schuetz
P012 - Do we need a lower procalcitonin cut off?
H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin
P013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteria
V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis
P014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiber
A. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. Imaizumi
P015 - Diagnostic usefullness of combination biomarkers on ICU admission
M. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-Alcantara
P016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patients
N. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. Nee
P017 - Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients
G. Nicolaes, M. Wiewel, M. Schultz, K. Wildhagen, J. Horn, R. Schrijver, T. Van der Poll, C. Reutelingsperger
P018 - Il-8: is this a more reliable biomarker for sepsis severity than CRP, Procalcitonin, E-selectin, IL-6 and TNF-[alpha]
S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans
P019 - Relation between adrenomedullin and short-term outcome in ICU patients: Results from the frog ICU study
E. G. Gayat, J. Struck, A. Cariou, N. Deye, B. Guidet, S. Jabert, J. Launay, M. Legrand, M. Léone, M. Resche-Rigon, E. Vicaut, A. Vieillard-Baron, A. Mebazaa
P020 - Impact of disease severity assessment on performance of heparin-binding protein for the prediction of septic shock
R. Arnold, M. Capan, A. Linder, P. Akesson
P021 - Kinetics and prognostic value of presepsin (sCD14) in septic patients. A pilot study
M. Popescu, D. Tomescu
P022 - Comparison of CD64 levels performed by the facs and accellix systems
C. L. Sprung, R. Calderon Morales, G. Munteanu, E. Orenbuch-Harroch, P. Levin, H. Kasdan, A. Reiter, T. Volker, Y. Himmel, Y. Cohen, J. Meissonnier
P023 - Diagnosing sepsis in 5 minutes: Nanofluidic technology study with pancreatic-stone protein (PSP/ reg)
L. Girard, F. Rebeaud
P024 - How nanotechnology-based approaches could contribute to sepsis prevention, diagnosis and treatment
I. Herrmann
P025 - Il7r transcriptional expression analysis during septic shock
B. Delwarde, E. Peronnet, E. Cerrato, F. Venet, A. Lepape, T. Rimmelé, G. Monneret, J. Textoris
P026 - Disbalance of microbial metabolites of aromatic acids affects the severity in critically ill patients
N. Beloborodova, V. Moroz, A. Osipov, A. Bedova, Y. Sarshor, A. Pautova, A. Sergeev, E. Chernevskaya
P027 - Copeptin predicts 10-year all-cause mortality in community patients
J. Odermatt, R. Bolliger, L. Hersberger, M. Ottiger, M. Christ-Crain, B. Mueller, P. Schuetz
P028 - Identification of differential proteomic response in septic patients secondary to community and hospital acquired pneumonia
N. K. Sharma, A. K. Tashima, M. K. Brunialti, F. R. Machado, M. Assuncao, O. Rigato, R. Salomao
P029 - Monocyte HLA-DR expression in community-acquired bacteremic sepsis - dynamics associated to aetiology and prediction of secondary sepsis
S. C. Cajander, G. Rasmussen, E. Tina, B. Söderquist, J. Källman, K. Strålin
P030 - Soluble B- and T-lymphocyte attenuator: A possible prognostic marker in sepsis
A. L. Lange, J. S. Sundén-Cullberg, A. M. Magnuson, O. H. Hultgren
P031 - Fractal dimension: A new biomarker for quantifying clot microstructure in patients across the sepsis spectrum
G. Davies, S. Pillai, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans
P032 - Comparison between the new biomarker for coagulation, clot microstructure (Df) with rotational thromboelastometry (ROTEM) in patients across the sepsis spectrum
S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans
P033 - Changes in fibrinolysis across the sepsis spectrum: The use of rotational thromboelastometry (ROTEM) lysis index (LI60) and D-Dimer concentration
S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans
P034 - The intensive care infection score – a promising marker for the prediction of infection and its severity.
P. Van der Geest, M. Mohseni, J. Linssen, R. De Jonge, S. Duran, J. Groeneveld
P035 - Challenges in the clinical diagnosis of sepsis
R. Miller III, B. K. Lopansri, L. C. McHugh, A. Seldon, J. P. Burke
P036 - Does zero heat flux thermometry more accurately identify sepsis on intensive care?
J. Johnston, R. Reece-Anthony, A. Bond, A. Molokhia
P037 - Advancing quality (AQ) sepsis programme: Improving early identification & treatment of sepsis in North West England.
C. Mcgrath, E. Nsutebu
P038 - Prehospital transport of acute septic patients
P. Bank Pedersen, D. Pilsgaard Henriksen, S. Mikkelsen, A. Touborg Lassen
P039 - Vasodilatory plant extracts gel as an alternative treatment for fever in critically ill patients
R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei
P040 - Host response and outcome of hypothermic sepsis
M. A. Wiewel, M. B. Harmon, L. A. Van Vught, B. P. Scicluna, A. J. Hoogendijk, J. Horn, A. H. Zwinderman, O. L. Cremer, M. J. Bonten, M. J. Schultz, T. Van der Poll, N. P. Juffermans, W. J. Wiersinga
P041 - Septic shock alert over SIRS criteria has an impact on outcome but needs to be revised
G. Eren, Y Tekdos, M. Dogan, O. Acicbe, E. Kaya, O. Hergunsel
P042 - Association between previous prescription of βblockers and mortality rate among septic patients: A retrospective observational study
S. Alsolamy, G. Ghamdi, L. Alswaidan, S. Alharbi, F. Alenezi, Y. Arabi
P043 - Recognition and treatment of sepsis on labour ward– teaching & information resources can improve knowledge
J. Heaton, A. Boyce, L. Nolan, J. Johnston, A. Dukoff-Gordon, A. Dean, A. Molokhia
P044 - Culture negative sepsis in the ICU – what is unique to this patient population?
T. Mann Ben Yehudah
P045 - Organ dysfunction in severe sepsis patients identified in administrative data in Germany, 2007-2013
C. Fleischmann, D. Thomas-Rueddel, C. Haas, U. Dennler, K. Reinhart
P046 - A comparison of residents’ knowledge regarding; the Surviving Sepsis Campaign 2012 guideline
O. Suntornlohanakul, B. Khwannimit
P047 - Effectiveness of a septic shock bundle to improve outcomes in the ICU
F. Breckenridge, A. Puxty
P048 - Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock
P. Szturz, P. Folwarzcny, J. Svancara, R. Kula, P. Sevcik
P049 - Norepinephrine or vasopressin + norepinephrine in septic shock. A retrospective series of 39 patients
L. Caneva, A. Casazza, E. Bellazzi, S. Marra, L. Pagani, M. Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L. Carnevale
P050 - Methylene blue effectiveness as contributory treatment in patients with septic shock
V. Lopez, M. Aguilar Arzapalo, L. Barradas, A. Escalante, J. Gongora, M. Cetina
P051 - Coagulation disorders in patients with severe sepsis and DIC evaluated with thromboelastometry.
B Adamik, D Jakubczyk, A Kübler
P052 - Frequency and outcome of early sepsis-associated coagulopathy
A. Radford, T. Lee, J. Singer, J. Boyd, D. Fineberg, M. Williams, J. Russell
P053 - Assessment of coagulopathy in cancer patients with severe sepsis or septic shock. A case-control pilot study
E. Scarlatescu, D. Tomescu, G. Droc, S. Arama
P054 - Thromboelastometry in critically ill patients with disseminated intravascular coagulation
M. Müller, M. Straat, S. S. Zeerleder, N. P. Juffermans
P055 - Cessation of a preexisting chronic antiplatelet therapy is associated with increased mortality rates in severe sepsis and septic shock
C. F. Fuchs, C. S. Scheer, S. W. Wauschkuhn, M. V. Vollmer, K. M. Meissner, S. K. Kuhn, K. H. Hahnenkamp, S. R. Rehberg, M. G. Gründling
P056 - Neutrophil Extracellular Traps (NETs) production under hypoxic condition
N. Yamamoto, M. Ojima, S. Hamaguchi, T. Hirose, Y. Akeda, R. Takegawa, O. Tasaki, T. Shimazu, K. Tomono
P057 - Impact of ultraviolet air sterilizer in intensive care unit room, and clinical outcomes of patients
E. Gómez-Sánchez, M. Heredia-Rodríguez, E. Álvarez-Fuente, M. Lorenzo-López, E. Gómez-Pesquera, M. Aragón-Camino, P. Liu-Zhu, A. Sánchez-López, A. Hernández-Lozano, M. T. Peláez-Jareño, E. Tamayo
P058 - Focus of infection in severe sepsis - comparison of administrative data and prospective cohorts from Germany
D. O. Thomas-Rüddel, C. Fleischmann, C. Haas, U. Dennler, K. Reinhart
P059 - “Zero CLABSI” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU
V. Adora, A. Kar, A. Chakraborty, S. Roy, A. Bandyopadhyay, M. Das
P060 - Novel molecular techniques to identify central venous catheter (CVC) associated blood stream infections (BSIs)
T. Mann Ben Yehudah, G. Ben Yehudah, M. Salim, N. Kumar, L. Arabi, T. Burger, P. Lephart, E. Toth-martin
P061 - Zero clabsi” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU
R. Rao, A. Kar, A. Chakraborty
P062 - Prevention of central line-associated bloodstream infections in intensive care units: An international online survey
C. Valencia, N. Hammami, S. Blot, J. L. Vincent, M. L. Lambert
P063 - 30 days antimicrobial efficacy of non-leaching central venous catheters
J. Brunke, T. Riemann, I. Roschke
P064 - Efficacy of noble metal alloy-coated catheter in prevention of bacteriuria
R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei
P065 - Predicting bacteremic urinary tract infection in community setting: A prospective observational study
S. Nimitvilai, K. Jintanapramote, S. Jarupongprapa
P066 - Eight-year analysis of acinetobacter spp. monobacteremia in surgical and medical intensive care units at university hospital in Lithuania
D. Adukauskiene, D. Valanciene
P067 - Group A and group B streptococcal infections in intensive care unit – our experience in a tertiary centre
G. Bose, V. Lostarakos, B. Carr
P068 - Improved detection of spontaneous bacterial peritonitis by uritop + tm strip test and inoculation of blood culture bottles with ascitic fluid
S. Khedher, A. Maaoui, A. Ezzamouri, M. Salem
P069 - Increased risk of cellulitis in patients with congestive heart failure: a population based cohort study
J. Chen
P070 - Outcomes of severe cellulitis and necrotizing fasciitis in the critically ill
D. R. Cranendonk, L. A. Van Vught, M. A. Wiewel, O. L. Cremer, J. Horn, M. J. Bonten, M. J. Schultz, T. Van der Poll, W. J. Wiersinga
P071 - Botulism outbreak associated with people who inject drugs (PWIDs) in Scotland.
M. Day, G. Penrice, K. Roy, P. Robertson, G. Godbole, B. Jones, M. Booth, L. Donaldson
P072 - Surveillance of ESBL-producing enterobacteriaceae fecal carriers in the ICU
Y. Kawano, H. Ishikura
P073 - Prevalence of ESBL and carbapenemase producing uropathogens in a newly opened hospital in south India
S. Sreevidya, N. Brahmananda Reddy, P. Muraray Govind, R. Pratheema, J. Devachandran
Apollo Speciality Hospital - OMR, Chennai, India
P074 - Prevalence, risk factors and outcomes of methicillin-resistant staphylococcus aureus nasal colonization in critically ill patients
H. Al-Dorzi, M. Almutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, B. Al Raiy, Y. Arabi
P075 - Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: Is there an association?
H. Talaie
P076 - Multidrug-resistant organisms in a Dutch ICU
J. A. Van Oers, A. Harts, E. Nieuwkoop, P. Vos
P077 - Epidemiology and risk factors of ICU acquired infections caused by multidrug-resistant gram negative bacilli
Y. Boussarsar, F. Boutouta, S. Kamoun, I. Mezghani, S. Koubaji, A. Ben Souissi, A. Riahi, M. S. Mebazaa
P078 - Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins
E. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis
P079 - Must change the medical practice in ICU?
A. R. Robles Caballero, B. Civantos, J. C. Figueira, J. López
P080 - Mediterranean spotted fever in an infectious diseases intensive care unit
A. Silva-Pinto, F. Ceia, A. Sarmento, L. Santos
P081 - Clinical features and outcomes of patients with Middle East respiratory syndrome requiring admission to a saudi intensive care unit: A retrospective analysis of 31 cases
G. Almekhlafi, Y. Sakr
P082 - The ICU response to a hospital outbreak of Middle East respiratory syndrome coronavirus infection
H. Al-Dorzi, R. Khan, S. Baharoon, A. Aldawood, A. Matroud, J. Alchin, S. Al Johani, H. Balkhy, Y. Arabi
P083 - Middle East respiratory syndrome: Surveillance data analysis
S. Alsolamy, S. Y. Yousif, B. O. Alotabi, A. S. Alsaawi
P085 - Use of Taqman array card molecular diagnostics in severe pneumonia: A case series
J. Ang, MD Curran, D. Enoch, V. Navapurkar, A. Conway Morris
P086 - ‘BUNS’: An investigation protocol improves the ICU management of pneumonia
R. Sharvill, J. Astin
P087 - Pneumonia in patients following secondary peritonitis: epidemiological features and impact on mortality
M. Heredia-Rodríguez, E. Gómez-Sánchez, M. T. Peláez-Jareño, E. Gómez-Pesquera, M. Lorenzo-López, P. Liu-Zhu, M. Aragón-Camino, A. Hernández-Lozano, A. Sánchez-López, E. Álvarez-Fuente, E. Tamayo
P088 - The use of the “CURB-65 score” by emergency room clinicians in a large teaching hospital
J. Patel, C. Kruger
P089 - Incidence of community acquired pneumonia with viral infection in mechanically ventilated patients in the medical intensive care unit
J. O’Neal, H. Rhodes, J. Jancik
P090 - The SAATELLITE Study: Prevention of S aureus Nosocomial Pneumonia (NP) with MEDI4893, a Human Monoclonal Antibody (mAb) Against S aureus
B. François, P. F. Laterre, P. Eggimann, A. Torres, M. Sánchez, P. F. Dequin, G. L. Bassi, J. Chastre, H. S. Jafri
P091 - Risk factors and microbiological profile for nosocomial infections in trauma patients
M. Ben Romdhane, Z. Douira, S. Kamoun, M. Bousselmi, A. Ben Souissi, Y. Boussarsar, A. Riahi, M.S. Mebazaa
P092 - Correlation between percentages of ventilated patients developed vap and use of antimicrobial agents in ICU patients.
A. Vakalos, V. Avramidis
P093 - A comparison of two ventilator associated pneumonia surveillance techniques
T. H. Craven, G. Wojcik, K. Kefala, J. McCoubrey, J. Reilly, R. Paterson, D. Inverarity, I. Laurenson, T. S. Walsh
P094 - Lung ultrasound before and after fiberbronchoscopy - modifications may improve ventilator-associated pneumonia diagnosis
S. Mongodi, B. Bouhemad, A. Orlando, A. Stella, G. Via, G. Iotti, A. Braschi, F. Mojoli
P095 - Comparing the accuracy of predictors of mortality in ventilator-associated pneumonia
M. Haliloglu, B. Bilgili, U. Kasapoglu, I. Sayan, M. Süzer Aslan, A. Yalcın, I. Cinel
P096 - Impact of pRBCs transfusion on percentage of ventilated patients developed VAP in ICU patients
A. Vakalos, V. Avramidis
P097 - The impact of a series of interventions on the rate of ventilator associated pneumonia in a large teaching hospital
H. E. Ellis, K. Bauchmuller, D. Miller, A Temple
P098 - The EVADE study: Prevention of Nosocomial Pneumonia (NP) caused by P aeruginosa with MEDI3902, a Novel Bispecific Monoclonal Antibody, against P aeruginosa virulence factors
J. Chastre, B. François, A. Torres, C. E. Luyt, M. Sánchez, M. Singer, H. S. Jafri
P099 - Short-term inhaled colistin adjunctive therapy for ventilator-associated pneumonia
Y. Nassar, M. S. Ayad
P100 - Effect of aerosolised colistin on weaning from mechanical ventilation
A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal
P101 - Septic shock is an independent risk factor for colistin-induced severe acute kidney injury: a retrospective cohort study
B. Bilgili, M. Haliloglu, F. Gul, I. Cinel
P102 - Nosocomial pneumonia - emphasis on inhaled tobramycin
A. Kuzovlev, A. Shabanov, S. Polovnikov, V. Moroz
P103 - In vitro evaluation of amikacin inhale and commercial nebulizers in a mechanical ventilator
N. Kadrichu, T. Dang, K. Corkery, P. Challoner
P104 - The effects of nebulized amikacin/fosfomycin and systemic meropenem on severe amikacin-resistant meropenem-susceptible P.aeruginosa pneumonia
G. Li Bassi, E. Aguilera, C. Chiurazzi, C. Travierso, A. Motos, L. Fernandez, R. Amaro, T. Senussi, F. Idone, J. Bobi, M. Rigol, A. Torres
P105 - Optimization of gentamicin peak concentrations in critically ill patients
C. J. Hodiamont, N. P. Juffermans, J. M. Janssen, C. S. Bouman, R. A. Mathôt, M. D. De Jong, R. M. Van Hest
P106 - Systematic review of cefepime induced neurotoxicity
L. Payne, G. L. Fraser
P107 - Unasyn® causes QT prolongation during treatment of intensive care patients
B. Tudor, M. Lahner, G. Roth, C. Krenn
P108 - Comparative study between teicoplanin and vancomycin in methicillin-resistant staphylococcus aureus (mrsa) infectious of toxicological intensive care unit (ticu) patients – Tehran, Iran
H. Talaie
P109 - Phage therapy against antimicrobial resistance, design of the first clinical study phagoburn
P. Jault, J. Gabard, T. Leclerc, S. Jennes, Y. Que, A. Rousseau, F. Ravat
P110 - Antibiotic dosing errors in critically ill patients with severe sepsis or septic shock
H. Al-Dorzi, A. Eissa, S. Al-Harbi, T. Aldabbagh, R. Khan, Y. Arabi
P111 - Does empiric antifungal therapy improve survival in septic critically ill patients? (immunocompromised excluded)
A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal
P112 - Neurocysticercosis-Qatar experience
F. Paramba, N. Purayil, V. Naushad, O. Mohammad, V. Negi, P. Chandra
P113 - Early indicators in acute haemorrhagic shock
A. Kleinsasser
P114 - Filtering of red blood cells reduces the inflammatory response of pulmonary cells in an in vitro model of mechanical ventilation
M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. C. Goslings, N. P. Juffermans
P115 - Microparticles from red blood cell transfusion induce a pro-coagulant and pro-inflammatory endothelial cell response
M. Van Hezel, M. Straat, A Boing, R Van Bruggen, N Juffermans
P116 - The contribution of cytokines on thrombosis development during hospitalization in ICU
D. Markopoulou, K. Venetsanou, V. Kaldis, D. Koutete, D. Chroni, I. Alamanos
P117 - Prophylactic enoxaparin dosing and adjustment through anti-xa monitoring in an inpatient burn unit
L. Koch, J. Jancik, H. Rhodes, E. Walter
P118 - Determination of optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma patients
K. Maekawa, M. Hayakawa, S. Kushimoto, A. Shiraishi, H. Kato, J. Sasaki, H. Ogura, T. Matauoka, T. Uejima, N. Morimura, H. Ishikura, A. Hagiwara, M. Takeda
P119 - Trauma-induced coagulopathy - prothrombin complex concentrate vs fresh frozen plasma
O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov
P120 - First study to prove the superiority of prothrombin complex concentrates on mortality rate over fresh frozen plasma in patients with acute bleeding
C. Plourde, J. Lessard, J. Chauny, R. Daoust
P121 - Prothrombin complex concentrate vs fresh frozen plasma in obstetric massive bleeding
S. Shcherbakow, O. Tarabrin, D. Gavrychenko, G. Mazurenko, O. Chystikov
P122 - Impact of FFP transfusion on VAP in ICU patients
A. Vakalos, V. Avramidis
P123 - Preoperative platelet function test and the thrombin generation assay are predictive for blood loss after cardiac surgery
L. Kropman, L. In het Panhuis, J. Konings, D. Huskens, E. Schurgers, M. Roest, B. De Laat, M. Lance
P124 - Rotational thromboelastometry versus standard coagulation tests before surgical interventions
M. Durila, P. Lukas, M. Astraverkhava, J. Jonas
P125 - Correction of impaired clot quality and stability by fibrinogen and activated prothrombin complex concentrate in a model of severe thrombocytopenia
I. Budnik, B. Shenkman
P126 - Assessment of point-of-care prothrombin time analyzer as a monitor after cardiopulmonary bypass
H. Hayami, Y. Koide, T. Goto
P127 - Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?
R. Iqbal, Y. Alhamdi, N. Venugopal, S. Abrams, C. Downey, C. H. Toh, I. D. Welters
P128 - Validity of the age-adjusted d-dimer cutoff in patients with COPD
B. Bombay, J. M. Chauny, R. D. Daoust, J. L. Lessard, M. M. Marquis, J. P. Paquet
P129 - A scoping review of strategies for prevention and management of bleeding following paediatric cardiopulmonary bypass surgery
K. Siemens, D. Sangaran, B. J. Hunt, A. Durward, A. Nyman, I. A. Murdoch, S. M. Tibby
P130 - Nadir hemoglobulin during cardiopulmonary bypass: impact on postoperative morbidity and mortality
F. Ampatzidou, D. Moisidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, G. Drossos
P131 - Red blood cell transfusion do not influence the prognostic value of RDW in critically ill patients
S. Spadaro, A. Fogagnolo, T. Fiore, A. Schiavi, V. Fontana, F. Taccone, C. Volta
P132 - Reasons for admission in the paediatric intensive care unit and the need for blood and blood products transfusions
E. Chochliourou, E. Volakli, A. Violaki, E. Samkinidou, G. Evlavis, V. Panagiotidou, M. Sdougka
P133 - The implementation of a massive haemorrhage protocol (mhp) for the management of major trauma: a ten year, single-centre study
R. Mothukuri, C. Battle, K. Guy, G. Mills, P. Evans
P134 - An integrated major haemorrhage protocol for pre-hospital and retrieval medical teams
J. Wijesuriya, S. Keogh
P135 - The impact of transfusion thresholds on mortality and cardiovascular events in patients with cardiovascular disease (non-cardiac surgery): a systematic review and meta-analysis
A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth
P136 - The relationship between poor pre-operative immune status and outcome from cardiac surgery is specific to the peri-operative antigenic threat
S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies
P137 - Impact of simple clinical practice guidelines for reducing post-operative atrial fibrillation after cardiac surgery.
A. Omar, M. Allam, O. Bilala, A. Kindawi, H. Ewila
P138 - Dexamethasone administration during cardiopulmonary bypass has no beneficial effects on elective postoperative cardiac surgery patients
F. Ampatzidou, D. Moisidou, M. Nastou, E. Dalampini, A. Malamas, E. Vasilarou, G. Drossos
P139 - Intra-aortic balloon counterpulsation in patients undergoing cardiac surgery (IABCS): preliminary results
G. Ferreira, J. Caldas, J. Fukushima, E. A. Osawa, E. Arita, L. Camara, S. Zeferino, J. Jardim, F. Gaioto, L. Dallan, F. B. Jatene, R. Kalil Filho, .F Galas, L. A. Hajjar
P140 - Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury
C. Mitaka, T. Ohnuma, T. Murayama, F. Kunimoto, M. Nagashima, T. Takei, M. Tomita
P141 - Acute kidney injury influence on high sensitive troponin measurements after cardiac surgery
A. Omar, K. Mahmoud, S. Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi
P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery
I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov
P143 - New-onset atrial fibrillation in intensive care: incidence, management and outcome
S. A. Jenkins, R. Griffin
P144 - One single spot measurement of the sublingual microcirculation during acute pulmonary hypertension in a pig model of shock
M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince
P145 - Assessment of levosimendan as a therapeutic option to recruit the microcirculation in cardiogenic shock – initial experience in cardiac ICU
A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon
P146 - Terlipressin vs. norepinephrine in the Potential Multiorgan Donor(PMD)
F. Righetti, E. Colombaroli, G. Castellano
P147 - Echocardiography in the potential heart donor exposed to substitution hormonotherapy
F. Righetti, E. Colombaroli
P148 - Machine learning can reduce rate of monitor alarms
M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky
P149 - Peripherally inserted central catheters placed in the ICU
S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon
P150 - Recordings of abnormal central venous pressure waveform morphology during an episode of pulmonary hypertension in a porcine shock model
M. S. Tovar Doncel, C. Ince, C. Aldecoa, A. Lima
P151 - Ultrasound guided central venous access technique among French intensivists
M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel
P152 - Predictive ability of the Pv-aCO2 gap in patients with shock
M. Shaban, R. Kolko, N. Salahuddin, M. Sharshir, M. AbuRageila, A. AlHussain
P153 - Comparison of echocardiography and pulmonary artery catheter measurements of hemodynamic parameters in critical ill patients
P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama
P154 - The volume clamp method for noninvasive cardiac output measurement in postoperative cardiothoracic surgery patients: a comparison with intermittent pulmonary artery thermodilution
J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel
P155 - Hemodynamic monitoring in patients with septic shock (SS) – CPCCO (continuous pulse contour cardiac output) vs. TEE (transesophageal echocardiography)
E. Colombaroli, F. Righetti, G. Castellano
P156 - Cardiac output measurement with transthoracic echocardiography in critically ill patients: a pragmatic clinical study
T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos
P157 - Left ventricular outflow tract velocity time integral correlates with stroke volume index in mechanically ventilated patients
Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana
P158 - Transpulmonary thermodilution (TPTD) derived from femoral vs. jugular central venous catheter: validation of a previously published correction formula and a proprietary correction formula for global end-diastolic volume index (GEDVI)
W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer
P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients
D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi
P159 - Venous return driving pressure and resistance in acute blood volume changes
P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger
P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients
D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi
P161 - Analysis of duration of post-operative goal-directed therapy protocol
C. Ostrowska, H. Aya, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, A. Rhodes, M. Cecconi
P162 - Hemodynamic optimization – back to square one?
M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm
P163 - Effectiveness of fluid thoracic content measurement by bioimpedance guiding intravascular volume optimization in patients with septic shock
M. Aguilar Arzapalo, L. Barradas, V. Lopez, M. Cetina
P164 - A systematic review on the role of internal jugular vein ultrasound measurements in assessment of volume status in critical shock patients
N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani
P165 - Importance of recognizing dehydration in medical Intensive Care Unit
M. Mackovic, N. Maric, M. Bakula
P166 - Effect of volume for a fluid challenge in septic patients
H. Aya, A. Rhodes, R. M. Grounds, N. Fletcher, M. Cecconi
P167 - Fluid bolus practices in a large Australian intensive care unit
B. Avard, P. Zhang
P168 - Liberal late fluid management is associated with longer ventilation duration and worst outcome in severe trauma patients: a retrospective cohort of 294 patients
M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila
P169 - Association of fluids and outcomes in emergency department patients hospitalized with community-acquired pneumonia
P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro
P170 - Association of positive fluid balance with poor outcome in medicosurgical ICU patients
A. Ben Souissi, I. Mezghani, Y. Ben Aicha, S. Kamoun, B. Laribi, B. Jeribi, A. Riahi, M. S. Mebazaa
P171 - Impact of fluid balance to organ dysfunction in critically ill patients
C. Pereira, R. Marinho, R. Antunes, A. Marinho
P172 - Volume bolus in ICU patients: do we need to balance our crystalloids?
M. Crivits, M. Raes, J. Decruyenaere, E. Hoste
P173 - The use of 6 % HES solution do not reduce total fluid requirement in the therapy of patients with burn shock
V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein
P174 - Electron microscopic assessment of acute kidney injury in septic sheep resuscitated with crystalloids or different colloids
T. Kampmeier , P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer
P175 - Alterations of conjunctival microcirculation in a sheep model of haemorrhagic shock and resuscitation with 0.9 % saline or balanced tetrastarch
P. Arnemann, M. Hessler, T. Kampmeier, S. Rehberg, H. Van Aken, C. Ince, C. Ertmer
P176 - A single centre nested pilot study investigating the effect of using 0.9 % saline or Plasma-Lyte 148 ® as crystalloid fluid therapy on gastrointestinal feeding intolerance in mechanically ventilated patients receiving nasogastric enteral nutrition
S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young
P177 - A single centre nested pilot study investigating the effect on post-operative bleeding of using 0.9 % saline or Plasma-Lyte® 148 as crystalloid fluid therapy in adults in ICU after heart surgery
S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young
P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management
H. Venkatesh, S. Ramachandran, A. Basu, H. Nair
P179 - Diagnosis and management of severe hypernatraemia in the critical care setting
S. Egan, J. Bates
P180 - Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients
S. Oliveira, N. R. Rangel Neto, F. Q. Reis
P181 - Missing the “I” in MUDPILES – a rare cause of high anion gap metabolic acidosis (HAGMA)
C. P. Lee, X. L. Lin, C. Choong , K. M. Eu, W. Y. Sim , K. S. Tee, J. Pau , J. Abisheganaden
P182 - Plasma NGAL and urinary output: potential parameters for early initiation of renal replacement therapy
K. Maas, H. De Geus
P183 - Renal replacement therapy for critically ill patients: an intermittent continuity
E. Lafuente, R. Marinho, J. Moura, R. Antunes, A. Marinho
P184 - A survey of practices related to renal replacement therapy in critically ill patients in the north of England.
T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez
P185 - High initiation creatinine associated with lower 28-day mortality in critically ill patients necessitating continuous renal replacement therapy
S. Stads, A. J. Groeneveld
P186 - The impact of Karnofsky performance scale on outcomes in acute kidney injury patients receiving renal replacement therapy on the intensive care unit
I. Elsayed, N. Ward, A. Tridente, A. Raithatha
P187 - Severe hypophosphatemia during citrate-anticoagulated CRRT
A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles
P188 - Citrate regional anticoagulation for post dilution continuous renal replacement therapy
S. Ghabina
P189 - Citrate 18 mmol/l improves anticoagulation during RRT with adsorbing filters
F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco
P190 - Calcium gluconate instead of calcium chloride in citrate-anticoagulated CVVHD
O. Demirkiran, M. Kosuk, S. Bozbay
P191 - Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis (CVVHD) using Ultraflux EMiC2 vs. Ultraflux AV1000S
V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann
P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics
S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti
P193 - Case series of patients with severe sepsis and septic shock treated with a new extracorporeal sorbent
T. Laddomada, A. Doronzio, B. Balicco
P194 - In vitro adsorption of a broad spectrum of inflammatory mediators with CytoSorb® hemoadsorbent polymer beads
M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan
P195 - Observations in early vs. late use of cytosorb therapy in critically ill patients
K. Kogelmann, M. Drüner, D. Jarczak
P196 - Oxiris membrane decreases endotoxin during rrt in septic patients with basal EAA > 0,6
F. Turani, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, R. Barchetta
P197 - An observational prospective study on the onset of augmented renal clearance: the first report
S. Morimoto, H. Ishikura
P198 - An ultrasound- guided algorithm for the management of oliguria in severe sepsis
I. Hussain, N. Salahuddin, A. Nadeem, K. Ghorab, K. Maghrabi
P199 - Ultrasound in acute kidney injury (aki). First findings of farius, an education-programme in structural ultrasonography
S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies
P200 - Effectiveness of renal angina index score predicting acute kidney injury on critically ill patients
M. Aguilar Arzapalo, L. Barradas, V. Lopez, A. Escalante, G. Jimmy, M. Cetina
P201 - Time length below blood pressure thresholds and progression of acute kidney injury in critically ill patients with or without sepsis: a retrospective, exploratory cohort study
J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura
P202 - Anaemia does not affect renal recovery in acute kidney injury
J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann
P203 - Estimated glomerular filtration rate based on serum creatinine: actual practice in Dutch ICU’s
A. Hana, H. R. De Geus
P204 - Comparison of estimated glomerular filtration rate calculated by mdrd, ckd-epi-serum-creatinine and ckd-epi-cystatin-c in adult critically ill patients
H. R. De Geus, A. Hana
P205 - Early diagnosis of septic acute kidney injury in medical critical care patients with a urine cell cycle arrest marker: insulin like growth factor binding protein-7 (IGFBP-7)
M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri
P206 - Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in intensive care
J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper
P207 - Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting
A. Dardashti, A. Grubb
P208 - The biomarker nephrocheck™ can discriminate the septic shock patients with an akin 1 or 2 acute renal failure who will not progress toward the akin 3 level
J. Maizel, M. Wetzstein, D. Titeca, L. Kontar, F. Brazier, B. De Cagny, A. Riviere, T. Soupison, M. Joris, M. Slama
P209 - A worldwide multicentre evaluation of acute kidney injury in septic and non-septic critically ill patients: the intensive care over nations (icon) audit
E. Peters, H. Njimi, P. Pickkers, J. L. Vincent
P210 - Does enhanced recovery after surgery reduce the incidence of acute kidney injury in those undergoing major gynae-oncological surgery?
M. Waraich , J. Doyle, T. Samuels, L. Forni
P211 - Identification of risk factors for the development of acute kidney injury after lower limb arthroplasty
N. Desai, R. Baumber, P. Gunning, A. Sell
P212 - Incidences and associations of acute kidney injury after major trauma
S. Lin, H. Torrence, M. O’Dwyer, C. Kirwan, J. Prowle
P213 - Acute kidney injury of major trauma patients
T Kim
P214 - Trajectory of serum creatinine after major surgery and the diagnosis of acute kidney injury
M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle
P215 - Epidemiology of acute kidney injury after cardiac surgery. A single center retrospective study
S. Hanoura , A. Omar, H. Othamn, S. Sudarsanan , M. Allam, M. Maksoud, R. Singh, A. Al Khulaifi
P216 - Post-operative acute kidney injury after major non-cardiac surgery and its association with death in the following year
M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle
P217 - Factors affecting acute renal failure in intensive care unit and effect of these factors on mortality
O. Uzundere, D. Memis , M. Ýnal, A. , N. Turan
P218 - Results of the live kidney transplantations according to national data of turkish organ and tissue information system
M. A. Aydin, H. Basar, I. Sencan, A. Kapuagasi, M. Ozturk, Z. Uzundurukan, D. Gokmen, A. Ozcan, C. Kaymak
P219 - Anaesthesia procedure and intensive therapy in patients with neck phlegmon
V. A. Artemenko, A. Budnyuk
P220 - Nasal high flow oygen for acute respiratory failure: a systematic review
R. Pugh , S. Bhandari
P221 - Setting optimal flow rate during high flow nasal cannula support: preliminary results
T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti
P222 - Dose to dose consistency across two different gas flow rates using cystic fibrosis and normal adult breathing profiles during nasal high flow oxygen therapy
L. Sweeney, A . O’ Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin
P223 - Final results of an evaluation of airway medix closed suction system compared to a standard closed suction system
M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi
P224 - Different cuff materials and different leak tests - one size does not fit all
T. Poropat, R. Knafelj
P225 - Observational study on the value of the cuff-leak test and the onset of upper airway obstruction after extubation
E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas
P226 - A device for emergency transtracheal lung ventilation
D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider
P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation
S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyenaere
P228 - Ultrasound-guided percutaneous dilational tracheostomy versus bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients (trachus): a randomized clinical trial
A. Gobatto, B. Bese, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson
P229 - Is it safe to discharge patients with tracheostomy from the ICU to the ward?
B. C. Civanto, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia
P230 - The application of tracheostomy in children in ICU
A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu
P231 - The impact of passive humidifiers on aerosol drug delivery during mechanical ventilation
P. Kelly, A. O’Sullivan, L. Sweeney, R. MacLoughlin
P232 - Evaluation of vibrating mesh and jet nebuliser performance at two different attachment setups in line with a humidifier nebuliser system
A. O’Sullivan, P. Kelly, L. Sweeney, E. Mukeria, M. Wolny , R. MacLoughlin
P233 - Psv-niv versus cpap in the treatment of acute cardiogenic pulmonary edema
A. Pagano, F. Numis, G. Vison, L. Saldamarco, T. Russo, G. Porta, F. Paladino
P234 - Noninvasive ventilation in patients with haematologic malignancy: a retrospective review
C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta
P235 - Use of non-invasive ventilation in infectious diseases besides classical indications
A. Silva-Pinto, A. Sarmento, L. Santos
P236 - The impact of fragility on noninvasive mechanical ventilation application and results in the ICU
Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, M. Aydogdu, G. Aygencel, Z. Ülger, G. Gursel
P237 - Effects of metabolic alkalosis on noninvasive ventilation success and ICU outcome in patients with hypercapnic respiratory failure
N. Boyacý, Z. Isýkdogan, Ö. Özdedeoglu, Z. Güllü, M. Badoglu, U. Gaygýsýz, M. Aydogdu, G. Gursel
P238 - Asynchrony index and breathing patterns of acute exacerbation copd patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assist
N. Kongpolprom, C. Sittipunt
P239 - High frequency jet ventilation for severe acute hypoxemia
A. Eden, Y. Kokhanovsky, S. Bursztein – De Myttenaere, R. Pizov
P240 - HFOV revisited: a 7 year retrospective analysis of patients receiving HFOV who met oscillate trial entry criteria
L. Neilans, N. MacIntyre
P241 - Implementation of a goal-directed mechanical ventilation order set driven by respiratory therapists can improve compliance with best practices for mechanical ventilation
M. Radosevich, B. Wanta, V. Weber, T. Meyer, N. Smischney, D. Brown, D. Diedrich
P242 - A reduction in tidal volumes for ventilated patients on ICU calculated from IBW. can it minimise mortality in comparison to traditional strategies?
A . Fuller, P. McLindon, K. Sim
P243 - Predictive value of lung aeration scoring using lung ultrasound in weaning failure
M. Shoaeir, K. Noeam, A. Mahrous, R. Matsa, A. Ali
P244 - Conventional versus automated weaning from mechanical ventilation using SmartCare™
C. Dridi, S. Koubaji, S. Kamoun, F. Haddad, A. Ben Souissi, B. Laribi, A. Riahi, M. S. Mebazaa
P245 - Ultrasonographic evaluation protocol for weaning from mechanichal ventilation
A. Pérez-Calatayud, R. Carrillo-Esper, A. Zepeda-Mendoza, M. Diaz-Carrillo, E. Arch-Tirado
P246 - Diaphragm ultrasonography: a method for weaning patients from mechanical ventilation
S. Carbognin, L. Pelacani, F. Zannoni, A. Agnoli, G. Gagliardi
P247 - Dorsal diaphragmatic excursion tracks transpulmonary pressure in ventilated ARDS patients: a potential non-invasive indicator of lung recruitment?
R. Cho, A. Adams , S. Lunos, S. Ambur, R. Shapiro, M. Prekker
P248 - Pulse oximetry in the icu patient: is the perfusion index of any value?
M. Thijssen, L. Janssen, N. Foudraine
P249 - Ventilation is a better assessment of respiratory status than EtCO2
C. J. Voscopoulos, J. Freeman
P250 - Evaluation of the relationship between non-invasive minute ventilation and end-tidal CO2 in patients undergoing general vs spinal anesthesia
C. J. Voscopoulos, J. Freeman, E. George
P251 - Respiratory volume monitoring provides early warning of respiratory depression and can be used to reduce false alarms in non-intubated patients
C. J. Voscopoulos, D. Eversole, J. Freeman, E. George
P252 - P/i index: a predictive edi-derived weaning index during nava
S. Muttini, R. Bigi, G. Villani, N. Patroniti
P253 - Adequacy of ventilation in patients receiving opioids in the post anesthesia care unit: minute ventilation versus respiratory rate
G. Williams, C. J. Voscopoulos, J. Freeman, E. George
P254 - Comparison of regional and global expiratory time constants measured by electrical impedance tomography (EIT)
A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis
P255 - Electrical impedance tomography: robustness of a new pixel wise regional expiratory time constant calculation
A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis
P256 - Validation of regional and global expiratory time constant measurement by electrical impedance tomography in ards and obstructive pulmonary diseases
C. K. Karagiannidis, A. W. Waldmann, S. B. Böhm, S. Strassmann, W. W. Windisch
P257 - Transpulmonary pressure in a model with elastic recoiling lung and expanding chest wall
P. Persson, S. Lundin, O. Stenqvist
P258 - Lactate in pleural and abdominal effusion
G. Porta, F. Numis, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero
P259 - Outcome of patients admitted to the intensive care with pulmonary fibrosis
F. Asota, K. O’Rourke, S. Ranjan, P. Morgan
P260 - Sedation and analgesia practice in extra-corporeal membrane oxygenation (ECMO)-treated patients with acute respiratory distress syndrome (ARDS): a retrospective study
J. W. DeBacker, E. Tamberg, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Mehta
P261 - Characteristics and outcomes of patients deemed not eligible when referred for veno-venous extracorporeal membrane oxygenation (vv-ECMO)
S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke
P262 - The SAVE SMR for veno-arterial ECMO
R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger
P263 - A simplified score to predict early (48 h) mortality in patients being considered for VA-ECMO
A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge
P264 - Lung function six months post extra corporeal membrane oxygenation (ECMO) for severe acute respiratory failure in adult survivors
C. Sampson, S. Harris-Fox
P265 - Bicarbonate dialysis removes carbon dioxide in hypoventilated rodents.
M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum
P266 - Procalcitonin as predictor of primary graft dysfunction and mortality in post-lung transplantation
C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello
P267 - New molecular biomarkers of acute respiratory distress syndrome in abdominal sepsis
A. K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk
P268 - Tight junction’s proteins claudin -5 and regulation by tnf in experimental murine lung injury model of ali/ards
V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos
P269 - Cell counts in endobronchial aspirate to assess airway inflammation in ARDS patients: a pilot study
S. Spadaro, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, C. Volta
P270 - Epidemiological and clinical profile of patients with acute respiratory distress syndrome in the surgical intensive care unit surgical, hospital JRA, Antananarivo
T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera
P271 - Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS. Is it good for the lung and for the heart?
S. El-Dash, ELV Costa, MR Tucci, F Leleu, L Kontar, B. De Cagny, F. Brazier, D. Titeca, G. Bacari-Risal, J. Maizel, M. Amato, M. Slama
P272 - Effect of recruitment maneuver on left ventricular systolic strain
P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, S. El Dash, M. Slama
P273 - Inhaled nitric oxide – is switching supplier cost effective?
Remmington, A. Fischer, S. Squire, M. Boichat
P274 - Epidemiological study of severe acute pancreatitis in Japan, comparison of the etiology and the patient outcomes on 1159 patients.
H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui
P275 - Extracorporeal liver support therapy. Experience in an intensive care unit
R. Marinho, J. Daniel, H. Miranda, A. Marinho
P276 - Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting
K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters
P277 - Risk of coronary artery disease in patients with chronic liver disease: a population based cohort study
Y. Su
P278 - 20 years of liver transplantation in Santiago de Compostela (Spain). Experience review
J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez
P279 - Diarrhea is a risk factor for liver injury and may lead to intestinal failure associated liver disease in critical illness
N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll
P280 - Bowel care on the intensive care unit: constipation guideline compliance and complications
K. Tizard, C. Lister, L. Poole
P281 - Malnutrition assessed by phase angle determines outcomes in low risk cardiac surgery patients
D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite
P282 - Preoperative fasting times in an irish hospital
A. O’Loughlin, V. Maraj, J. Dowling
P283 - Costs and final outcome of early x delayed feeding in a private Brazil ICU
M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes
P284 - Can ventilator derived energy expenditure measurements replace indirect calorimetry?
T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard
P285 - Revisiting the refeeding syndrome: results of a systematic review
N. Friedli, Z. Stanga, B. Mueller, P. Schuetz
P286 - Compliance with the new protocol for parenteral nutrition in our ICU
L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois
P287 - Nutrition may be another treatment in the intensive care unit where less is more?
R. Marinho, H. Castro, J. Moura, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, A. Marinho
P288 - Should we provide more protein to critically ill patients?
R. Marinho, M. Santos, E. Lafuente, H. Castro, S. Cabral, J. Moura, P. Martins, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, P. Casteloes, A. Marinho
P289 Protein provision in an adult intensive care unit
S. Gray
P290 - Prevalence and clinical outcomes of vitamin d deficiency in the medical critically ill patients in Songklanagarind hospital
K. Maipang, R. Bhurayanontachai
P291 - Vitamin d deficiency strongly predicts adverse medical outcome across different medical inpatient populations: results from a prospective study
L. G. Grädel, P. Schütz
P292 - Omega-3 fatty acids in patients undergoing cardiac surgery: a systematic review and meta-analysis
P. Langlois, W. Manzanares
P293 - Can 5-hydroxytriptophan prevent post-traumatic stress disorder in critically ill patients?
R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei
P294 - Parenteral selenium in the critically ill: an updated systematic review and meta-analysis
W. Manzanares, P. Langlois, M. Lemieux, G. Elke, F. Bloos, K. Reinhart, D. Heyland
P295 - Probiotics in the critically ill: an updated systematic review and meta-analysis
P. Langlois, M. Lemieux, I. Aramendi, D. Heyland, W. Manzanares
P296 - Diabetes with hyperglycemic crisis episodes may be associated with higher risk of pancreatic cancer: a population-based cohort study
Y. Su
P297 - Incidence of hypoglycemia in an intensive care unit depending on insulin protocol
R. Marinho, N. Babo, A. Marinho
P298 - Severity of the diseases is two-dimensionally correlated to blood glucose, including blood glucose variability, especially in moderately to severely ill patients with glucose intolerance.
M. Hoshino, Y. Haraguchi, S. Kajiwara, T. Mitsuhashi, T. Tsubata, M. Aida
P299 - A study of glycemic control by subcutaneous glargine injection transition from continuous regular insulin infusion in critically ill patients
T. Rattanapraphat, R. Bhurayanontachai, C. Kongkamol, B. Khwannimit
P300 - Glycemic control in Portuguese intensive care unit
R. Marinho, M. Santos, H. Castro, E. Lafuente, A. Salgueiro, S. Cabral, P. Martins, J. Moura, B. Oliveira, M. Melo, B. Xavier, J. Valente, C. Magalhaes, P. Casteloes, A. Marinho
P301 - Impact of hyperglycemia duration on the day of operation on short-term outcome of cardiac surgery patients
D. Moisidou, F. Ampatzidou, C. Koutsogiannidis, M. Moschopoulou, G. Drossos
P302 - Lactate levels in diabetic ketoacidosis patients at ICU admissions
G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel
P303 - Intensive care implications of merging heart attack centre units in London
J. M. Wong, C. Fitton, S. Anwar, S. Stacey
P304 - Special characteristics of in-hospital cardiac arrests
M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis
P305 - Clinical evaluation of ICU-admitted patients who were resuscitated in the general medicine ward
S. Suda , T. Ikeda, S. Ono, T. Ueno, Y. Izutani
P306 - Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders
S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon
P307 - Public and clinical staff perceptions and knowledge of CPR compared to local and national data
J. C White, A. Molokhia, A. Dean, A. Stilwell, G. Friedlaender
P308 Dispatcher-assisted telephone cardiopulmonary resuscitation using a French-language compression-ventilation pediatric protocol
M. Peters, S. Stipulante, A. Delfosse, AF Donneau, A. Ghuysen
P309 Dantrolene versus amiodarone for resuscitation – an experimental study
C. Feldmann, D. Freitag, W. Dersch, M. Irqsusi, D. Eschbach, T. Steinfeldt, H. Wulf, T. Wiesmann
P310 Long term survival and functional neurological outcome in comatose survivors undergoing therapeutic hypothermia
N. Kongpolprom, J. Cholkraisuwat
P311 Impact of kidney disease on mortality and neurological outcome in out-of-hospital cardiac arrest: a prospective observational study
S. Beitland , E. Nakstad, H. Stær-Jensen , T. Drægni , G. Andersen , D. Jacobsen , C. Brunborg, B. Waldum-Grevbo , K. Sunde
P312 ICU dependency of patients admitted after primary percutaneous coronary intervention (PPCI) following out of the hospital cardiac arrest
K. Hoyland, D. Pandit
P313 Prognostic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: comprehensive registry of in-hospital intensive care on OHCA survival (critical) study in Osaka, Japan
K. Hayakawa
P314 Cerebral oxygen saturation during resuscitation in a porcine model of cardiac arrest
E. Oloktsidou, K. Kotzampassi, B. Fyntanidou, S. Patsatzakis, L. Loukipoudi, E. Doumaki, V. Grosomanidis
P315 Presumption of cardiopulmonary resuscitation for sustaining cerebral oxidation using regional cerebral saturation of oxygen: observational cohort study (press study)
H. Yasuda
P316 EEG reactivity in patients after cardiac arrest: a close look at stimuli
MM Admiraal, M. Van Assen, MJ Van Putten, M. Tjepkema-Cloostermans, AF Van Rootselaar, J. Horn
P317 Prognostic value of neuron-specific enolase after cardiac arrest
F. Ragusa, A. Marudi , S. Baroni, A. Gaspari, E. Bertellini
P318 Correlation between electroencephalographic findings and serum neuron specific enolase with outcome of post cardiac arrest patients
A. Taha, T. Abdullah, S. Abdel Monem
P319 Introduction of a targeted temperature management strategy following cardiac arrest in a district general hospital intensive care unit.
S. Alcorn, S. McNeill, S. Russell
P320 The evolution of cerebral oxygen saturation in post-cardiac arrest patients treated with therapeutic hypothermia
W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne
P321 Prognostic factors and neurological outcomes of therapeutic hypothermia in comatose survivors from cardiac arrest: 8-year single center experience
J. Cholkraisuwat, N. Kongpolprom
P322 Adherence to targeted temperature management after out of hospital cardiac arrest
B. Avard, R. Burns
P323 Implementation of a therapeutic hypothermia protocol for comatose survivors of out-of-hospital cardiac arrest.
A. Patarchi, T. Spina
P324 Factors associated with ventilator weaning after targeted temperature management for cardiac arrest patients in japan
H. Tanaka, N. Otani, S. Ode, S. Ishimatsu
P325 Differential activation of c-fos in paraventricular nuclei of the hypothalamus and thalamus of the rat following myocardial infarction
J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin, M. H. Won
P326 Monitoring of cTroponin I in patients with acute ischemic stroke - predictor of inhospital mortality
S. Dakova, Z. Ramsheva, K. Ramshev
P327 Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing sods expressions
J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin
P328 Failure in neuroprotection of remote limb ischemic post conditioning in the hippocampus of a gerbil model of transient cerebral ischemia
J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin
P329 Brain death and admission diagnosis in neurologic intensive care unit, a correlation?
A Marudi, S Baroni, A Gaspari, E Bertellini
P330 Brain magnetic resonance imaging findings in patients with septic shock
G. Orhun, E. Senturk, P. E. Ozcan, S. Sencer, C. Ulusoy, E. Tuzun, F . Esen
P331 Benefits of L-carnitine in valproic acid induced encephalopathy
R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei
P332Automatic analysis of EEG reactivity in comatose patients
M. Van Assen, M. M. Admiraal, M. J. Van Putten, M. Tjepkema-Cloostermans, A. F. Van Rootselaar, J. Horn
P333 Usefulness of common ICU severity scoring systems in predicting outcome after spontaneous intracerebral hemorrhage
M. Fallenius, M. B. Skrifvars, M. Reinikainen, S. Bendel, R. Raj
P334 Evalution of patients with suspected subarachnoid haemorrhage and negative ct imaging
M. Abu-Habsa, C. Hymers, A. Borowska, H. Sivadhas, S. Sahiba, S. Perkins
P335 Timing of endovascular and surgical treatment for aneurysmal subarachnoid haemorrhage: early but not so fast.
J. Rubio, J. A. Rubio, R. Sierra
P336 Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the Sahara cohort study
S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre
P337 - Aneurysmal subarachnoid hemorrhage and anemia: a canadian multi-centre retrospective cohort study
S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre
P338 - Does the neutrophil-to-lymphocyte (NLR) ratio predict symptomatic vasospasm or delayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (SAH)?
T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson
P339 - ICU-acquired infections in aneurysmal subarachnoid hemorrhage patients: impact on ICU and hospital length of stay
M. Carbonara , F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti
P340 - Cerebral metabolic effects of normobaric hyperoxia during the acute phase of aneurysmal subarachnoid hemorrhage
L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo
P341 - Postoperative care for elective craniotomy: where is best done?
J. A. Rubio, J. Rubio, R. Sierra
P342 - 5-year follow-up of patients after transplantation of organs from donors from neurocritical care
V. Spatenkova, E. Pokorna, P. Suchomel
P343 - Evaluation of levetiracetam pharmacokinetics after severe traumatic brain injury in neurocritical care patients at a level one trauma center
N. Ebert, J. Jancik, H. Rhodes
P344 - Model based time series cluster analysis to determine unique patient states in traumatic brain injury
T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella
P345 - Brain compartment monitoring capabilities from ICP to BI (bioimpedance) during HS (hypertonic saline) administration. State of art simulation outcome depending on brain swelling type
A. K. Kink , I. R. Rätsep
P346 - Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study
A. Boutin, L. Moore, M. Chasse, R. Zarychanski, F. Lauzier, S. English, L. McIntyre, J. Lacroix, D. Griesdale, P. Lessard-Bonaventure, A. F. Turgeon
P347 - Hemoglobin thresholds and red blood cell transfusions in adult patients with moderate or severe traumatic brain injury: a retrospective cohort study
A. Boutin, L. Moore, R. Green, P. Lessard-Bonaventure, M. Erdogan, M. Butler, F. Lauzier, M. Chasse, S. English, L. McIntyre, R. Zarychanski, J. Lacroix, D. Griesdale, P. Desjardins, D. A. Fergusson, A. F. Turgeon
P348 - Characteristics of patients with gunshot wounds to the head - an observational Brazilian study
B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez
P349 - Base excess as predictor for ICU admission and the injury severity in blunt trauma patients
T. Hong
P350 - Enhancement of usual emergency department care with proadrenomedullin to improve outcome prediction - Results from the multi-national, prospective, observational TRIAGE study
A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, B. Mueller, P. Schuetz
P351 - Developing an innovative emergency medicine point-of-care simulation programme
T. Brown, J. Collinson, C. Pritchett, T. Slade
P352 - The InSim program: an in situ simulation program for junior trainees in intensive care
M. Le Guen, S. Hellings, R. Ramsaran
P353 - Impact of excessive and inappropriate troponin testing in the emergency setting how good are we
A. Alsheikhly
P354 - The development of time tracking monitor at emergency department
T. Abe
P355 - Role of focussed echocardiography in emergency assessment of syncope
L. Kanapeckaite, M. Abu-Habsa, R. Bahl
P356 - Insertion of an open-ended 14-gauge catheter through the chest wall causes a significant pneumothorax in a self-ventilating swine model
M. Q Russell, K. J. Real, M. Abu-Habsa , R. M. Lyon, N. P. Oveland
P357 - Ez-io® intraosseous access teaching in the workplace using a mobile ‘tea trolley’ training method
J. Penketh, M. Mcdonald, F. Kelly
P358 - Black widow envenomation in Saudi Arabia: a prospective observational case series
M. Alfafi, S. Alsolamy, W. Almutairi, B. Alotaibi
P359 - Mechanical ventilation in patients with overdose not yet intubated on icu admission
A. E. Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar
P360 - Central nervous system depressants poisoning and ventilator associated pneumonia: an underrated risk factor in toxicological intensive care unit
H. Talaie
P361 - Acute barium intoxication treated with hemodiafiltration
D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva
P362 - Major trauma presenting to the emergency department. the spectrum of cycling injuries in Ireland
J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan
P363 - Burns from French military operations: a 14-year retrospective observational analysis.
M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, T. Leclerc
P364 - A comparison of mortality scores in burns patients on the intensive care unit.
O. Howarth, K. Davenport, P. Jeanrenaud, S. Raftery
P365 - Clasification of pain and its treatment and an intensive care rehabiliation clinic
P. MacTavish, H. Devine, J. McPeake, M. Daniel, J. Kinsella, T. Quasim
P366 - Pain management adequacy in critical care areas ,the process and the barriers perceived by critical care nurses
S. Alrabiee, A. Alrashid , S. Alsolamy
P367 - Pain assessment in critically ill adult patients: validation of the Turkish version of the critical-care pain observation tool
O. Gundogan, C. Bor, E. Akýn Korhan, K. Demirag , M. Uyar
P368 - An audit of pain and sedation assessments in the intensive care unit: recommendations for clinical practice
F. Frame, C. Ashton, L. Bergstrom Niska
P369 - Impact of pharmaceutical care on treatment of pain and agitation in medical intensive care unit
P. Dilokpattanamongkol, T. Suansanae, C. Suthisisang, S. Morakul, C. Karnjanarachata, V. Tangsujaritvijit
P370 - Agitation in trauma ICU, prevention and outcome
S. Mahmood, H. Al Thani, A. Almenyar
P371 Correlation between percentages of ventilated patients developed vap and use of sedative agents in icu patients.
A. Vakalos , V. Avramidis
P372 - Improving recording of sedation events in the Emergency Department: The implementation of the SIVA International Taskforce adverse event reporting tool for procedural sedation
R. Sharvill, J. Penketh
P373 - Impact of sedative drug use on the length of mechanical ventilation
S. E. Morton, Y. S. Chiew, C. Pretty, J. G. Chase, G. M. Shaw
P374 - Co-administration of nitric oxide and sevoflurane using anaconda
R. Knafelj, P. Kordis
P375 - A retrospective study of the use of Dexmedetomidine in an oncological critical care setting
S. Patel, V. Grover
P376 - Dexmedetomidine and posttraumatic stress disorder incidence in alcohol withdrawal icu patients
I. Kuchyn, K. Bielka
P377 - Hemodynamic effects of dexmedetomidine in a porcine model of septic shock
Z. Aidoni, V. Grosomanidis, K. Kotzampassi, G. Stavrou, B. Fyntanidou, S. Patsatzakis, C. Skourtis
P378 - Ketamine for analgosedation in severe hypoxic respiratory failure
S. D. Lee, K. Williams, I. D. Weltes
P379 - Madness from the moon? lunar cycle and the incidence of delirium on the intensive care unit
S. Berhane, C. Arrowsmith, C. Peters, S. Robert
P380 - Impaired dynamic cerebral autoregulation after coronary artery bypass grafting and association with postoperative delirium
J. Caldas, R. B. Panerai, T. G. Robinson, L. Camara, G. Ferreira, E. Borg-Seng-Shu, M. De Lima Oliveira, N. C. Mian, L. Santos, R. Nogueira, S. P. Zeferino, M. Jacobsen Teixeira, F. Galas, L. A. Hajjar
P381 - Risk factors predicting prolonged intensive care unit length of stay after major elective surgery.
P. Killeen, M. McPhail, W. Bernal, J. Maggs, J. Wendon, T. Hughes
P382 - Systemic inflammatory response syndrome criteria and hospital mortality prediction in a brazilian cohort of critically ill patients
L. U. Taniguchi, E. M. Siqueira, J. M. Vieira Jr, L. C. Azevedo
P383 - Evaluating the efficacy of a risk predictor panel in identifying patients at elevated risk of morbidity following emergency admission
A. N. Ahmad, M. Abu-Habsa, R. Bahl, E. Helme, S. Hadfield, R. Loveridge
P384 - A retrospective comparison of outcomes for elective surgical patients admitted post-operatively to the critical care unit or general ward
J. Shak, C. Senver, R. Howard-Griffin
P385 - Effect of obesity on mortality in surgical critically ill patients.
P. Wacharasint, P. Fuengfoo, N. Sukcharoen, R. Rangsin
P386 - The national early warning score (news) reliably improves adverse clinical outcome prediction in community-acquired pneumonia - results from a 6 year follow-up
D. Sbiti-Rohr, P. Schuetz
P387 - Clinical usefulness of the charlson¡¯s weighted index of comorbidities _as prognostic factor in patients with prolonged acute mechanical ventilation
H. Na, S. Song, S. Lee, E. Jeong, K. Lee
P388 - Comparison of mortality prediction scoring systems in patients with cirrhosis admitted to general intensive care unit
M. Cooper, K. Milinis, G. Williams, E. McCarron, S. Simants, I. Patanwala, I. D. Welters
P389 - Impact of admission source and time of admission on outcome of pediatric intensive care patients: retrospective 15 years study
E. Zoumpelouli, EA Volakli, V. Chrysohoidou, S. Georgiou, K. Charisopoulou, E. Kotzapanagiotou, V. Panagiotidou, K. Manavidou, Z. Stathi, M. Sdougka
P390 - Heart rate variability and outcomes prediction in critical illness
N. Salahuddin, B. AlGhamdi, Q. Marashly, K. Zaza, M. Sharshir, M. Khurshid, Z. Ali, M. Malgapo, M. Jamil, A. Shafquat, M. Shoukri, M. Hijazi
P391 - The incidence and outcome of hyperlactatemia in the post anaesthesia care unit
T. Abe, S. Uchino, M. Takinami
P392 - Correlation between arterial blood gas disturbances and arterial lactate levels during hospitalization and outcome in critically septic patients
N. R. Rangel Neto, S. Oliveira, F. Q. Reis, F. A. Rocha
P393 - External validation of saps 3 and mpm iii scores in 48,816 patients from 72 brazilian icus
G. Moralez, K. Ebecken, L. S. Rabello, M. F. Lima, R. Hatum, F. V. De Marco, A. Alves, J. E. Pinto, M. Godoy, P. E. Brasil, F. A. Bozza, J. I. Salluh, M. Soares
P394 - The frailty penalty: pre-admission functional status confounds mortality prediction models in critically ill patients
J. Krinsley, G. Kang
P395 - ‘sooner rather than later”: how delayed discharge from critical care leads to increased out of hours discharges and subsequent increase in in-hospital mortality.
J. Perry, H. Hines
P396 - Identifying poor outcome patient groups in a resource-constrained critical care unit
K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy
P397 - Effects of icu weekend admission and discharge on mortality.
E. Moreira, F. Verga, M. Barbato, G. Burghi
P398 - Organizational factors, outcomes and resource use in 9,946 cancer patients admitted to 70 ICUs
M Soares, U. V. Silva, L. C. Azevedo, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, P. E. Brasil, F. A. Bozza, J. I. Salluh
P399 - Evaluation of oncological critically ill patients, severity score and outcome compared to not oncological in a particular hospital cti.
M. B. Velasco, D. M. Dalcomune
P400 - Outcomes of patients admitted to a large uk critical care department with palliative oncological diagnoses
R. Marshall, T. Gilpin, A. Tridente, A. Raithatha
P401 - Predictors of mortality in febrile neutropenic patients with haematological malignancies admitted to an intensive care unit of a cancer center
D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria
P402 - Patients with hematologic malignancies requiring invasive mechanical ventilation: characteristics and predictors of mortality
H. Al-Dorzi, H. Al Orainni , F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, Y. Arabi
P403 - Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review
S. Gaudry, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, D. Dreyfuss, F. Tubach
P404 - Alopecia in survivors of critical illness: a qualitative study
C . Battle, K. James, P. Temblett
P405 - The impact of mental health on icu admission
L. Davies, C. Battle, C. Lynch
P406 - Cognitive impairment 5 years after ICU discharge
S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso
P407 - Apache ii versus apache iv for octagenerians in medical icu
M. Fister, R. Knafelj
P408 - Outcomes of octagenarians in an indian icu
P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran
P409 - Mortality and outcomes in elderly patients 80 years of age or older admitted to the icu
M. B. Velasco , D. M. Dalcomune
P410 - Octagenerians in medical icu - adding days to life or life to days?
R. Knafelj, M. Fister
P411 - The very elderly admitted to intensive care unit: outcomes and economic evaluation
N. Chin-Yee, G. D’Egidio, K. Thavorn, D. Heyland, K. Kyeremanteng
P412 - The very elderly in intensive care: relationship between acuity of illness and long-term mortality
A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott
P413 - Acquired weakness in an oncological intensive care unit
I. Guerreiro
P414 - Musculoskeletal problems in intensive care unit (ICU) patients post-discharge
H. Devine, P. MacTavish, J. McPeake, T. Quasim, J. Kinsella, M. Daniel
P415 - Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness
C. Goossens M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche
P416 - Physical outcome measures for critical care patients following intensive care unit (icu) discharge
H. Devine, P. MacTavish, T. Quasim, J. Kinsella, M. Daniel, J. McPeake
P417 - Improving active mobilisation in a general intensive care unit
B. Miles , S. Madden, H. Devine
P418 - Mobilization in patients on vasoactive drugs use – a pilot study.
M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade
P419 - Pharmacy intervention at an intensive care rehabilitation clinic
P. MacTavish, J. McPeake, H. Devine, J. Kinsella, M. Daniel, R. Kishore, C. Fenlon, T. Quasim
P420 - Interactive gaming is feasible and potentially increases icu patients’ motivation to be engaged in rehabilitation programs
T. Fiks, A. Ruijter, M. Te Raa, P. Spronk
P421 - Simulation-based design of a robust stopping rule to ensure patient safety
Y. S. Chiew, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, C. Pretty, G. M. Shaw, J. G. Chase
P422 - Are daily blood tests on the intensive care unit necessary?
T. Hall, W. C. Ngu, J. M. Jack, P. Morgan
P423 - Measuring urine output in ward patients: is it helpful?
B. Avard, A. Pavli, X. Gee
P424 - The incidence of pressure ulcers in an adult mixed intensive care unit in turkey
C . Bor, E. Akin Korhan, K. Demirag, M. Uyar
P425 - Intensivist/patient ratios in closed ICUs in Alexandria, Egypt; an overview
M. Shirazy, A. Fayed
P426 - Eicu (electronic intensive care unit): impact on ALOS (average length of stay) in a developing country like India
S. Gupta, A. Kaushal, S. Dewan, A. Varma
P427 - Predicting deterioration in general ward using early deterioration indicator
E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson
P428 - High impact enhanced critical care outreach - the imobile service: making a difference
E. Helme, R. Broderick, S. Hadfield, R. Loveridge
P429 - Impact of bed availability and cognitive load on intensive care unit (ICU) bed allocation: a vignette-based trial
J. Ramos, D. Forte
P430 - Characteristics of critically ill patients admitted through the emergency department
F. Yang, P. Hou
P431 - Admission to critical care: the quantification of functional reserve
J. Dudziak, J. Feeney, K. Wilkinson, K. Bauchmuller, K. Shuker, M. Faulds, A. Raithatha, D. Bryden, L. England, N. Bolton, A. Tridente
P432 - Admission to critical care: the importance of frailty
K. Bauchmuller, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Research Collaboration
P433 - Development of an instrument to aid triage decisions for intensive care unit admission
J. Ramos, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I . Velasco, D. Forte
P434 - Using selective serotonin re-uptake inhibitors and serotonin-norepinephrine re-uptake inhibitors in critical care: a systematic review of the evidence for benefit or harm
J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min
P435 - Measuring adaptive coping of hospitalized patients with a severe medical condition:the sickness insight in coping questionnaire (sicq)
E. Boezeman, J. Hofhuis , A. Hovingh, R. De Vries, P. Spronk
P436 - Results of a national survey regarding intensive care medicine training
G. Cabral-Campello, I. Aragão, T. Cardoso
P437 - Work engagement among healthcare professionals in the intensive care unit
M. Van Mol, M. Nijkamp, E . Kompanje
P438 - Empowering the intensive care practitioners. is it a burnout ameliorating intervention?
P. Ostrowski, A. Omar
P439 - Icu patients suffer from circadian rhythm desynchronisation
K. Kiss , B. Köves, V. Csernus, Z. Molnár
P440 - Noise reduction in the ICU: feasible ?
Y. Hoydonckx, S. Vanwing, B. Stessel, A. Van Assche, L. Jamaer, J. Dubois
P441 - Accidental removal of invasive devices in the critical patient into the bed-washing. does the presence of professional nurse modify his incidence?
V. Medo, R. Galvez, J. P. Miranda
P442 - Deprivation of liberty safeguards (dols): audit of compliance in a of a 16-bed specialist cancer critical care unit.
C. Stone, T. Wigmore
P443 - Use of a modified cristal score to predict futility of critical care in the elderly
Y. Arunan, A. Wheeler, K. Bauchmuller, D. Bryden
P444 - Improvement of Referral Rate to Palliative Care for Patients with Poor Prognosis in Neurosurgical Intensive Care Unit
Y. Wong, C. Poi, C. Gu
P445 - Factors associated with limitation of life supporting care (lsc) in a medico-surgical intermediate care unit, and outcome of patients with lsc limitation: a monocentric, six-month study.
P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat
P446 - Palliative care consultation and intensive care unit admission request: a cohort study
J. Ramos, M. Correa, R. T. Carvalho, D. Forte
P447 - Nursing and medicine together in postsurgical intensive care unit: situations of prognostic conflict at the end of life. our critical care nurses suffer with our medical activism?
A. Fernandez, C. McBride
P448 - End of life who may decide
E. Koonthalloor, C. Walsh
P449 - Correctly diagnosing death
A. Webber, M. Ashe, K. Smith, P. Jeanrenaud
P450 - Skin procurement performed by intensive care physicians: yes, we can.
A. Marudi , S. Baroni, F. Ragusa, E. Bertellini
P451 - Death analysis in pediatric intensive care patients
E. A. Volakli , E. Chochliourou, M. Dimitriadou, A. Violaki, P. Mantzafleri, E. Samkinidou, O. Vrani, A. Arbouti, T. Varsami, M. Sdougka
P452 - The potential impact of euthanasia on organ donation: analysis of data from belgium
J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook
P453 - Communication within an intensive care setting
K. Sim, A. Fuller
P454 - Development and implementation of a longitudinal communication curriculum for critical care medicine fellows
A. Roze des Ordons, P. Couillard, C. Doig
P455 - Staff-family conflict in a multi-ethnic intensive care unit
R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen
P456 - Does the source of admission to critical care affect family satisfaction?
B. Nyamaizi, C. Dalrymple, A. Molokhia, A. Dobru
P457 - A simple alternative to the family satisfaction survey (fs-icu)
E. Marrinan, A. Ankuli, A. Molokhia
P458 - A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis
J. McPeake, R. Struthers, R. Crawford , H. Devine , P. Mactavish , T. Quasim
P459 - Prevalence and risk factors of anxiety and depression in relatives of burn patients.
P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, F. Verga, J. Cabrera, G. Burghi
P460 - Guidance of visiting children at an adult intensive care unit (icu)
A. Rutten , S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen
P461 - Visiting policies in Italian pediatric ICUs: an update
A. Giannini, G Miccinesi, T Marchesi, E Prandi
doi:10.1186/s13054-016-1208-6
PMCID: PMC5493079  PMID: 27885969
7.  Cell-specific nuclear import of plasmid DNA 
Gene therapy  1999;6(6):1006-1014.
One factor limiting the success of non-viral gene therapy vectors is the relative inability to target genes specifically to a desired cell type. To address this limitation, we have begun to develop cell-specific vectors whose specificity is at the level of the nuclear import of the plasmid DNA. We have recently shown that nuclear import of plasmid DNA is a sequence-specific event, requiring the SV40 enhancer, a region known to bind to a number of general transcription factors. From these studies we developed a model whereby transcription factor(s) bind to the DNA in the cytoplasm to create a protein–DNA complex that can enter the nucleus using the protein import machinery. Our model predicts that by using DNA elements containing binding sites for transcription fac tors expressed in unique cell types, we should be able to create plasmids that target to the nucleus in a cell-specific manner. Using the promoter from the smooth muscle gamma actin (SMGA) gene whose expression is limited to smooth muscle cells, we have created a series of reporter plasmids that are expressed selectively in smooth muscle cells. Moreover, when injected into the cytoplasm, plas mids containing portions of the SMGA promoter localize to the nucleus of smooth muscle cells, but remain cytoplas mic in fibroblasts and CV1 cells. In contrast, a similar plasmid carrying the SV40 enhancer is transported into the nuclei of all cell types tested. Nuclear import of the SMGA promoter-containing plasmids could be achieved when the smooth muscle specific transcription factor SRF was expressed in stably transfected CV1 cells, supporting our model for the nuclear import of plasmids. Finally, these nuclear targeting sequences were also able to promote increased gene expression in liposome- and polycation-transfected non-dividing cells in a cell-specific manner, similar to their nuclear import activity. These results pro vide proof of principle for the development of cell-specific non-viral vectors for any desired cell type.
doi:10.1038/sj.gt.3300924
PMCID: PMC4408932  PMID: 10455402
nuclear import; non-viral vectors; cell specificity; plasmid DNA
8.  Nuclear Import of Plasmid DNA in Digitonin-permeabilized Cells Requires Both Cytoplasmic Factors and Specific DNA Sequences* 
The Journal of biological chemistry  1999;274(31):22025-22032.
Although much is known about the mechanisms of signal-mediated protein and RNA nuclear import and export, little is understood concerning the nuclear import of plasmid DNA. Plasmids between 4.2 and 14.4 kilobases were specifically labeled using a fluorescein-conjugated peptide nucleic acid clamp. The resulting substrates were capable of gene expression and nuclear localization in microinjected cells in the absence of cell division. To elucidate the requirements for plasmid nuclear import, a digitonin-permeabilized cell system was adapted to follow the nuclear localization of plasmids. Nuclear import of labeled plasmid was time- and energy-dependent, was inhibited by the lectin wheat germ agglutinin, and showed an absolute requirement for cytoplasmic extract. Addition of nuclear extract alone did not support plasmid nuclear import but in combination with cytoplasm stimulated plasmid nuclear localization. Whereas addition of purified importin α, importin β, and RAN was sufficient to support protein nuclear import, plasmid nuclear import also required the addition of nuclear extract. Finally, nuclear import of plasmid DNA was sequence-specific, requiring a region of the SV40 early promoter and enhancer. Taken together, these results confirm and extend our findings in microinjected cells and support a protein-mediated mechanism for plasmid nuclear import.
PMCID: PMC4397984  PMID: 10419528
9.  The association between brain injury, perioperative anesthetic exposure, and 12-month neurodevelopmental outcomes after neonatal cardiac surgery: a retrospective cohort study 
Paediatric anaesthesia  2014;24(3):266-274.
Summary
Background
Adverse neurodevelopmental outcomes are observed in up to 50% of infants after complex cardiac surgery. We sought to determine the association of perioperative anesthetic exposure with neurodevelopmental outcomes at age 12 months in neonates undergoing complex cardiac surgery and to determine the effect of brain injury determined by magnetic resonance imaging (MRI).
Methods
Retrospective cohort study of neonates undergoing complex cardiac surgery who had preoperative and 7-day postoperative brain MRI and 12-month neurodevelopmental testing with Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Doses of volatile anesthetics (VAA), benzodiazepines, and opioids were determined during the first 12 months of life.
Results
From a database of 97 infants, 59 met inclusion criteria. Mean ± sd composite standard scores were as follows: cognitive = 102.1 ± 13.3, language = 87.8 ± 12.5, and motor = 89.6 ± 14.1. After forward stepwise multivariable analysis, new postoperative MRI injury (P = 0.039) and higher VAA exposure (P = 0.028) were associated with lower cognitive scores. ICU length of stay (independent of brain injury) was associated with lower performance on all categories of the Bayley-III (P < 0.02).
Conclusions
After adjustment for multiple relevant covariates, we demonstrated an association between VAA exposure, brain injury, ICU length of stay, and lower neurodevelopmental outcome scores at 12 months of age. These findings support the need for further studies to identify potential modifiable factors in the perioperative care of neonates with CHD to improve neurodevelopmental outcomes.
doi:10.1111/pan.12350
PMCID: PMC4152825  PMID: 24467569
congenital heart disease; neonate; neurodevelopment; inhaled agents; intravenous agents; general anesthesia
10.  Relaxin Decreases the Severity of Established Hepatic Fibrosis in Mice 
Background
Hepatic fibrosis is characterized by excess collagen deposition, decreased extracellular matrix degradation, and activation of the hepatic stellate cells. The hormone relaxin has shown promise in the treatment of fibrosis in a number of tissues, but the effect of relaxin on established hepatic fibrosis is unknown.
Aims
The aim of this study was to determine the effect of relaxin on an in vivo model after establishing hepatic fibrosis.
Methods
Male mice were made fibrotic by carbon tetrachloride treatment for 4 weeks, followed by treatment with two doses of relaxin (25 or 75 ug/kg/day) or vehicle for 4 weeks, with continued administration of carbon tetrachloride.
Results
Relaxin significantly decreased total hepatic collagen and smooth muscle actin content at both doses, and suppressed collagen I expression at the higher dose. Relaxin increased the expression of the matrix metalloproteinases MMP13 and MMP3, decreased expression of MMP2 and tissue inhibitor of metalloproteinases 2 (TIMP2), and increased the overall level of collagen degrading activity. Relaxin decreased TGFβ-induced Smad2 nuclear localization in mouse hepatic stellate cells.
Conclusions
The results suggest that relaxin reduced collagen deposition and HSC activation in established hepatic fibrosis despite the presence of continued hepatic insult. This reduced fibrosis was associated with increased expression of the fibrillar collagen-degrading enzyme MMP13, decreased expression of TIMP2, and enhanced collagen degrading activity, and impaired TGFβ signaling, consistent with relaxin's effects on activated fibroblastic cells. The results suggest that relaxin may be an effective treatment for the treatment of established hepatic fibrosis.
doi:10.1111/liv.12247
PMCID: PMC3843971  PMID: 23870027
Liver disease; relaxin family peptides; cirrhosis; hepatic stellate cells; collagen
11.  Sequence requirements for plasmid nuclear import 
Experimental cell research  1999;253(2):713-722.
SUMMARY
The nuclear envelope is a major barrier for nuclear uptake of plasmids and represents one of the most significant unsolved problems of non-viral gene delivery. We have previously shown that the nuclear entry of plasmid DNA is sequence-specific, requiring a 366 bp fragment containing the SV40 origin of replication and early promoter. In this report, we show that, although fragments throughout this region can support varying degrees of nuclear import, the 72 bp repeats of the SV40 enhancer facilitate maximal transport. The functions of the promoter and the origin of replication are not needed for nuclear localization of plasmid DNA. In contrast to the import activity of the SV40 enhancer, two other strong promoter and enhancer sequences, the human cytomegalovirus (CMV) immediate early promoter and the Rous sarcoma virus LTR, were unable to direct nuclear localization of plasmids. The inability of the CMV promoter to mediate plasmid nuclear import was confirmed by measurement of the CMV promoter-driven expression of green fluorescent protein (GFP) in microinjected cells. At times before cell division, as few as 3 to 10 copies per cell of cytoplasmically injected plasmids containing the SV40 enhancer gave significant GFP expression, while no expression was obtained with more than 1000 copies per cell of plasmids lacking the SV40 sequence. However, the levels of expression were the same for both plasmids after cell division in cytoplasmically injected cells and at all times in nuclear injected cells. Thus, the inclusion this SV40 sequence in non-viral vectors may greatly increase their ability to be transported into the nucleus, especially in non-dividing cells.
doi:10.1006/excr.1999.4716
PMCID: PMC4152905  PMID: 10585295
nuclear import; gene expression; gene therapy; enhancer; plasmid delivery
12.  Erythropoietin Neuroprotection in Neonatal Cardiac Surgery: A Phase I/II Safety and Efficacy Trial 
Objectives
Neonates undergoing complex congenital heart surgery have a significant incidence of neurological problems. Erythropoietin has anti-apoptotic, anti-excitatory, and anti-inflammatory properties to prevent neuronal cell death in animal models, and improves neurodevelopmental outcomes in full term neonates with hypoxic ischemic encephalopathy. We designed a prospective phase I/II trial of erythropoietin neuroprotection in neonatal cardiac surgery to assess safety, and indicate efficacy.
Methods
Neonates undergoing surgery for D-transposition of the great vessels, hypoplastic left heart syndrome, or aortic arch reconstruction were randomized to 3 perioperative doses of erythropoietin, or placebo. Neurodevelopmental testing with Bayley Scales of Infant and Toddler Development III was performed at age 12 months.
Results
59 patients received study drug. Safety profile, including MRI brain injury, clinical events, and death, was not different between groups. 3 patients in each group died. 42 patients (22 erythropoietin, 20 placebo, 79% of survivors) returned for 12-month follow-up. The mean Cognitive Scores were erythropoietin, 101.1 ± 13.6, placebo, 106.3 ± 10.8 (p=0.19); Language Scores were erythropoietin 88.5 ± 12.8, placebo 92.4 ± 12.4 (p=0.33); and Motor Scores were erythropoietin 89.9 ± 12.3, placebo 92.6 ± 14.1, (p=0.51).
Conclusions
Safety profile for erythropoietin administration was not different than placebo. Neurodevelopmental outcomes were not different between groups, however this pilot study was not powered to definitively address this outcome. Lessons learned from the current study suggest optimized study design features for a larger prospective trial to definitively address the utility of erythropoietin for neuroprotection in this population.
doi:10.1016/j.jtcvs.2012.09.046
PMCID: PMC3579008  PMID: 23102686
Cardiopulmonary bypass; brain; magnetic resonance imaging; pediatrics
13.  A linear programming approach to reconstructing subcellular structures from confocal images for automated generation of representative 3D cellular models 
Medical image analysis  2013;17(3):337-347.
This paper presents a novel computer vision algorithm to analyze 3D stacks of confocal images of fluorescently stained single cells. The goal of the algorithm is to create representative in silico model structures that can be imported into finite element analysis software for mechanical characterization. Segmentation of cell and nucleus boundaries is accomplished via standard thresholding methods. Using novel linear programming methods, a representative actin stress fiber network is generated by computing a linear superposition of fibers having minimum discrepancy compared with an experimental 3D confocal image. Qualitative validation is performed through analysis of seven 3D confocal image stacks of adherent vascular smooth muscle cells (VSMCs) grown in 2D culture. The presented method is able to automatically generate 3D geometries of the cell's boundary, nucleus, and representative F-actin network based on standard cell microscopy data. These geometries can be used for direct importation and implementation in structural finite element models for analysis of the mechanics of a single cell to potentially speed discoveries in the fields of regenerative medicine, mechanobiology, and drug discovery.
doi:10.1016/j.media.2012.12.002
PMCID: PMC3626120  PMID: 23395283
Automatic cell segmentation; Representative F-actin network; Confocal microscopy; Finite element model geometry
14.  A Computational Approach to Understand Phenotypic Structure and Constitutive Mechanics Relationships of Single Cells 
Annals of biomedical engineering  2012;41(3):630-644.
The goal of this study is to construct a representative 3D finite element model (FEM) of individual cells based on their sub-cellular structures that predicts cell mechanical behavior. The FEM simulations replicate atomic force microscopy (AFM) nanoindentation experiments on live vascular smooth muscle cells. Individual cells are characterized mechanically with AFM and then imaged in 3D using a spinning disc confocal microscope. Using these images, geometries for the FEM are automatically generated via image segmentation and linear programming algorithms. The geometries consist of independent structures representing the nucleus, actin stress fiber network, and cytoplasm. These are imported into commercial software for mesh refinement and analysis. The FEM presented here is capable of predicting AFM results well for 500 nm indentations. The FEM results are relatively insensitive to both the exact number and diameter of fibers used. Despite the localized nature of AFM nanoindentation, the model predicts that stresses are distributed in an anisotropic manner throughout the cell body via the actin stress fibers. This pattern of stress distribution is likely a result of the geometric arrangement of the actin network.
doi:10.1007/s10439-012-0690-5
PMCID: PMC3594057  PMID: 23180027
Automatically generated geometries; Confocal microscopy; Atomic force microscopy; Finite element model; Cell mechanics
15.  Neurodevelopmental Outcomes Following Regional Cerebral Perfusion with Neuromonitoring for Neonatal Aortic Arch Reconstruction 
The Annals of thoracic surgery  2012;95(2):648-655.
Background
In this study we report magnetic resonance imaging (MRI) brain injury, and 12 month neurodevelopmental outcomes, when regional cerebral perfusion (RCP) is utilized for neonatal aortic arch reconstruction.
Methods
Fifty seven neonates receiving RCP during aortic arch reconstruction were enrolled in a prospective outcome study. RCP flows were determined by near-infrared spectroscopy and transcranial Doppler monitoring. Brain MRI were performed preoperatively and 7 days postoperatively. Bayley Scales of Infant Development III was performed at 12 months.
Results
Mean RCP time was 71 ± 28 minutes (range 5–121), mean flow 56.6 ± 10.6 ml/kg/min. New postoperative MRI brain injury was seen in 40% of patients. For 35 RCP patients at age 12 months, mean Bayley III composite standard scores were: Cognitive = 100.1 ± 14.6,(range 75–125); Language = 87.2 ± 15.0, (range 62–132); Motor = 87.9 ± 16.8, (range 58–121).Increasing duration of RCP was not associated with adverse neurodevelopmental outcomes.
Conclusions
Neonatal aortic arch repair with RCP utilizing a neuromonitoring strategy results in 12-month cognitive outcomes that are at reference population norms; language and motor outcomes are lower than the reference population norms by 0.8–0.9 standard deviation. This largest RCP group with neurodevelopmental outcomes published to date demonstrates that this technique is effective and safe in supporting the brain during neonatal aortic arch reconstruction.
doi:10.1016/j.athoracsur.2012.04.070
PMCID: PMC3586430  PMID: 22766302
Anesthesia; brain; cardiopulmonary bypass (CPB); CHD; hypoplastic left heart syndrome; neurocognitive deficits
16.  Changing Expectations for Neurological Outcomes After the Neonatal Arterial Switch Operation 
The Annals of thoracic surgery  2012;94(4):1250-1256.
Background
Expectations for outcomes after the neonatal arterial switch operation (ASO) continue to change. This cohort study describes neurodevelopmental outcomes at age 12 months after neonatal ASO, and analyzes both modifiable, and non-modifiable factors for association with adverse outcomes.
Methods
ASO patients (n=30) were enrolled in a prospective outcome study, with comprehensive clinical data collection over the first 12 months of life. Brain magnetic resonance imaging (MRI) was done preoperatively and 7 days postoperatively, Bayley Scales of Infant Development III was performed at age 12 months.
Results
Ten of 30 patients (33%) had preoperative MRI injury; 13 of 30 (43%) had new postoperative MRI injury. 20 (67%) patients had Bayley Scales of Infant Development III: Cognitive score mean was 104.8 ± 15.0, Language score median was 90.0 (25th–75th percentile 83–94), and Motor score mean was 92.3 ± 14.2. Best subsets multivariable analysis found associations between lower preoperative and intraoperative cerebral oxygen saturation, preoperative MRI brain injury, total bypass time, and total midazolam dose and lower Bayley Scales of Infant Development III scores at age 12 months.
Conclusions
At 12 months after ASO, neurodevelopmental outcome means were within normal population ranges. The new associations reported in this study between potentially modifiable perioperative factors and outcomes require investigations in larger patient cohorts. Beyond survival, which was 100% in this cohort, factors influencing quality of life including neurodevelopmental outcomes, should be routinely investigated in studies of ASO patients.
doi:10.1016/j.athoracsur.2012.04.050
PMCID: PMC3586524  PMID: 22748448
Anesthesia; brain; cardiopulmonary bypass (CPB); CHD; arterial switch operation; neurocognitive deficits
17.  Chemical Variation in a Dominant Tree Species: Population Divergence, Selection and Genetic Stability across Environments 
PLoS ONE  2013;8(3):e58416.
Understanding among and within population genetic variation of ecologically important plant traits provides insight into the potential evolutionary processes affecting those traits. The strength and consistency of selection driving variability in traits would be affected by plasticity in differences among genotypes across environments (G×E). We investigated population divergence, selection and environmental plasticity of foliar plant secondary metabolites (PSMs) in a dominant tree species, Eucalyptus globulus. Using two common garden trials we examined variation in PSMs at multiple genetic scales; among 12 populations covering the full geographic range of the species and among up to 60 families within populations. Significant genetic variation in the expression of many PSMs resides both among and within populations of E. globulus with moderate (e.g., sideroxylonal A h2op = 0.24) to high (e.g., macrocarpal G h2op = 0.48) narrow sense heritabilities and high coefficients of additive genetic variation estimated for some compounds. A comparison of Qst and Fst estimates suggest that variability in some of these traits may be due to selection. Importantly, there was no genetic by environment interaction in the expression of any of the quantitative chemical traits despite often significant site effects. These results provide evidence that natural selection has contributed to population divergence in PSMs in E. globulus, and identifies the formylated phloroglucinol compounds (particularly sideroxylonal) and a dominant oil, 1,8-cineole, as candidates for traits whose genetic architecture has been shaped by divergent selection. Additionally, as the genetic differences in these PSMs that influence community phenotypes is stable across environments, the role of plant genotype in structuring communities is strengthened and these genotypic differences may be relatively stable under global environmental changes.
doi:10.1371/journal.pone.0058416
PMCID: PMC3603948  PMID: 23526981
18.  Brain Immaturity is Associated with MRI Brain Injury Before and After Neonatal Cardiac Surgery with High-Flow Bypass and Cerebral Oxygenation Monitoring 
Background
New intraparenchymal brain injury on MRI is observed in 36–73% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). Brain immaturity in this population is common. We performed brain magnetic resonance imaging (MRI) before and after neonatal cardiac surgery, using a high flow CPB protocol, hypothesizing that MRI brain injury would be associated with brain immaturity.
Methods
CPB protocol included 150 ml/kg/min flows, pH stat management, hematocrit >30%, and high flow antegrade cerebral perfusion. Regional brain oxygen saturation (rSO2) was monitored, with a treatment protocol for rSO2 <50%. Brain MRI, consisting of T1, T2, and diffusion weighted imaging, and MR spectroscopy were performed preoperatively, 7 days postoperatively, and at age 3–6 months.
Results
Twenty-four of 67 patients (36%) had new postoperative white matter injury (WMI), infarction, or hemorrhage, and 16% had new WMI. Associations with preoperative brain injury included low brain maturity score (p=0.002). Postoperative WMI was associated with single ventricle (SV) diagnosis (p=0.02), preoperative WMI (p<0.001) and low brain maturity score (p=0.05). Low brain maturity score was also associated with more severe postoperative brain injury (p=0.01). Forty-five patients had a 3rd scan, with a 27% incidence of new minor lesions, but 58% of previous lesions had partially or completely resolved.
Conclusions
We observed a significant incidence of both pre- and postoperative MRI abnormality, and an association with brain immaturity. Many lesions resolved in the first 6 months after surgery. Timing of delivery and surgery with bypass could affect the risk of brain injury.
doi:10.1016/j.jtcvs.2009.08.022
PMCID: PMC2827639  PMID: 19909994
heart defects; congenital; bypass; brain; surgery; anesthesia
19.  Left Frontal Lobe Contributions to Concept Formation: A Quantitative MRI Study of D-KEFS Sorting Test Performance 
This study examined relationships between lobar volumes and performance on the D-KEFS Sorting Test, a standardized measure of concept formation. Participants included 89 subjects, 19 patients with probable Alzheimer's disease, 25 patients with frontotemporal dementia, 13 patients with semantic dementia, 12 patients with progressive nonfluent aphasia, 9 patients with probable progressive supranuclear palsy, 2 patients with possible progressive supranuclear palsy, and 9 healthy participants. We used BRAINS2 software to generate volumes of the right and left frontal, temporal, and parietal lobes. Multiple regression analysis indicated that, after controlling for Mini-Mental State Examination scores, intracranial volume, and demographic variables, only the left frontal lobe significantly predicted performance on the D-KEFS Sorting test.
doi:10.1080/13803390802419017
PMCID: PMC2743528  PMID: 19031322
D-KEFS; Frontal lobes; Executive functioning; Card Sorting; Concept Formation
20.  Relaxin Reduces Fibrosis in Models of Progressive and Established Hepatic Fibrosis 
The effect of relaxin administration before (prevention) or after (treatment) the establishment of hepatic fibrosis in a mouse model was examined. In the prevention study, relaxin reduced collagen and smooth muscle actin (SMA) content, and significantly reduced serum levels of the liver enzymes ALT and AST. In the treatment study, relaxin for 1 week reduced collagen and SMA, but not liver enzyme levels. Relaxin for 2 weeks had no significant effect. In conclusion, the data suggest that relaxin treatment before fibrosis can reduce collagen and improve liver function, but that there is little effect of short-term relaxin treatment after fibrosis is established.
doi:10.1111/j.1749-6632.2008.03783.x
PMCID: PMC2716062  PMID: 19416217
Hepatic fibrosis; liver; collagen; relaxin
21.  Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction 
Cardiovascular toxicology  2008;9(1):1-12.
Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT) and stavudine (d4T), cause toxicities to numerous tissues, including the liver and vasculature. While much is known about hepatic NRTI toxicity, the mechanism of toxicity in endothelial cells is incompletely understood. Human aortic endothelial and HepG2 liver cells were exposed to 1 μM AZT or d4T for up to 5 weeks. Markers of oxidative stress, mitochondrial function, NRTI phosphorylation, mitochondrial DNA (mtDNA) levels, and cytotoxicity were monitored over time. In endothelial cells, AZT significantly oxidized glutathione redox potential, increased total cellular and mitochondrial-specific superoxide, decreased mitochondrial membrane potential, increased lactate release, and caused cell death from weeks 3 through 5. Toxicity occurred in the absence of di- and tri-phosphorylated AZT and mtDNA depletion. These data show that oxidative stress and mitochondrial dysfunction in endothelial cells occur with a physiologically relevant concentration of AZT, and require long-term exposure to develop. In contrast, d4T did not induce endothelial oxidative stress, mitochondrial dysfunction, or cytotoxicity despite the presence of d4T-triphosphate. Both drugs depleted mtDNA in HepG2 cells without causing cell death. Endothelial cells are more susceptible to AZT-induced toxicity than HepG2 cells, and AZT caused greater endothelial dysfunction than d4T because of its pro-oxidative effects.
doi:10.1007/s12012-008-9029-8
PMCID: PMC2714048  PMID: 19067249
Zidovudine; Stavudine; Oxidative stress; Endothelium; Toxicity; Mitochondria; mtDNA pol-γ
22.  Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration 
Human immunodeficiency virus (HIV)-infected patients have a higher incidence of oxidative stress, endothelial dysfunction, and cardiovascular disease than uninfected individuals. Recent reports have demonstrated that viral proteins upregulate reactive oxygen species, which may contribute to elevated cardiovascular risk in HIV-1 patients. In this study we employed an HIV-1 transgenic rat model to investigate the physiological effects of viral protein expression on the vasculature. Markers of oxidative stress in wild-type and HIV-1 transgenic rats were measured using electron spin resonance, fluorescence microscopy, and various molecular techniques. Relaxation studies were completed on isolated aortic rings, and mRNA and protein were collected to measure changes in expression of nitric oxide (NO) and superoxide sources. HIV-1 transgenic rats displayed significantly less NO-hemoglobin, serum nitrite, serum S-nitrosothiols, aortic tissue NO, and impaired endothelium-dependent vasorelaxation than wild-type rats. NO reduction was not attributed to differences in endothelial NO synthase (eNOS) protein expression, eNOS-Ser1177 phosphorylation, or tetrahydrobiopterin availability. Aortas from HIV-1 transgenic rats had higher levels of superoxide and 3-nitrotyrosine but did not differ in expression of superoxide-generating sources NADPH oxidase or xanthine oxidase. However, transgenic aortas displayed decreased superoxide dismutase and glutathione. Administering the glutathione precursor procysteine decreased superoxide, restored aortic NO levels and NO-hemoglobin, and improved endothelium-dependent relaxation in HIV-1 transgenic rats. These results show that HIV-1 protein expression decreases NO and causes endothelial dysfunction. Diminished antioxidant capacity increases vascular superoxide levels, which reduce NO bioavailability and promote peroxynitrite generation. Restoring glutathione levels reverses HIV-1 protein-mediated effects on superoxide, NO, and vasorelaxation.
doi:10.1152/ajpheart.91447.2007
PMCID: PMC2586125  PMID: 18456725
acquired immunodeficiency syndrome; antioxidants; superoxide
23.  Magnetic resonance imaging correlates of set shifting 
The purpose of this study was to examine the relationships between lobar volumes and set shifting. We studied 101 subjects, including 36 normal controls, 16 patients with probable Alzheimer’s disease, 30 patients with frontotemporal dementia (FTD), and 19 patients with semantic dementia (SD), using a shifting paradigm that carefully controlled for component abilities. Subjects were administered two conditions of the Delis-Kaplan Executive Function System (D-KEFS) Design Fluency Test. In the control condition (DF:Control), examinees generated as many unique designs as possible in 60 s by drawing lines connecting only unfilled dots. In the switching condition (DF:Switch), examinees generated designs by drawing lines alternating between filled and unfilled dots. We used BRAINS2 software to generate volumes of the right and left frontal, temporal, and parietal lobes. Partial correlations and multiple regressions showed that, after controlling for Mini-Mental State Examination and DF:Control, only the right and left frontal lobe volumes significantly correlated with the DF:Switch, most clearly in the FTD and SD groups. Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning.
doi:10.1017/S1355617707070567
PMCID: PMC2443737  PMID: 17445286
FTD; AD; D-KEFS; Frontal lobes; BRAINS2; Design fluency
24.  Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415 
Haemophilus influenzae isolates vary widely in their susceptibilities to the peptide deformylase inhibitor LBM415 (MIC range, 0.06 to 32 μg/ml); however, on average, they are less susceptible than gram-positive organisms, such as Staphylococcus aureus and Streptococcus pneumoniae. Insertional inactivation of the H. influenzae acrB or tolC gene in strain NB65044 (Rd strain KW20) increased susceptibility to LBM415, confirming a role for the AcrAB-TolC pump in determining resistance. Consistent with this, sequencing of a PCR fragment generated with primers flanking the acrRA region from an LBM415-hypersusceptible H. influenzae clinical isolate revealed a genetic deletion of acrA. Inactivation of acrB or tolC in several clinical isolates with atypically reduced susceptibility to LBM415 (MIC of 16 μg/ml or greater) significantly increased susceptibility, confirming that the pump is also a determinant of decreased susceptibility in these clinical isolates. Examination of acrR, encoding the putative repressor of pump gene expression, from several of these strains revealed mutations introducing frameshifts, stop codons, and amino acid changes relative to the published sequence, suggesting that loss of pump repression leads to decreased susceptibility. Supporting this, NB65044 acrR mutants selected by exposure to LBM415 at 8 μg/ml had susceptibilities to LBM415 and other pump substrates comparable to the least sensitive clinical isolates and showed increased expression of pump genes.
doi:10.1128/AAC.49.8.3129-3135.2005
PMCID: PMC1196275  PMID: 16048914
25.  Serine / threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling 
BMC Cell Biology  2001;2:6.
Background
In most cells glucocorticoid receptors (GR) reside predominately in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription of GR-responsive genes. Serine/threonine protein phosphatase type 5 (PP5) associates with the GR-heat-shock protein-90 complex, and the suppression of PP5 expression with ISIS 15534 stimulates the activity of GR-responsive reporter plasmids, without affecting the binding of hormone to the GR.
Results
To further characterize the mechanism by which PP5 affects GR-induced gene expression, we employed immunofluorescence microscopy to track the movement of a GR-green fluorescent fusion protein (GR-GFP) that retained hormone binding, nuclear translocation activity and specific DNA binding activity, but is incapable of transactivation. In the absence of glucocorticoids, GR-GFP localized mainly in the cytoplasm. Treatment with dexamethasone results in the efficient translocation of GR-GFPs into the nucleus. The nuclear accumulation of GR-GFP, without the addition of glucocorticoids, was also observed when the expression of PP5 was suppressed by treatment with ISIS 15534. In contrast, ISIS 15534 treatment had no apparent effect on calcium induced nuclear translocation of NFAT-GFP.
Conclusion
These studies suggest that PP5 participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling, and that the GR-induced transcriptional activity observed when the expression of PP5 is suppressed by treatment with ISIS 15534 results from the nuclear accumulation of GR in a form that is capable of binding DNA yet still requires agonist to elicit maximal transcriptional activation.
doi:10.1186/1471-2121-2-6
PMCID: PMC32197  PMID: 11389770

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