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1.  Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU) 
BMJ Open  2017;7(12):e019253.
Optimal targets for systemic oxygenation in paediatric critical illness are unknown. Observational data indicate that high levels of arterial oxygenation are associated with poor outcomes in resuscitation of the newborn and in adult critical illness. Within paediatric intensive care units (PICUs), staff prevent severe hypoxia wherever possible, but beyond this there is no consensus. Practice varies widely with age, diagnosis, treating doctor and local or national guidelines followed, though peripheral blood oxygen saturations (SpO2) of >95% are often targeted. The overall aim of this pilot study is to determine the feasibility of performing a randomised trial in critically ill children comparing current practice of liberal SpO2 targets with a more conservative target.
Methods and analysis
Oxy-PICU is a pragmatic, open, pilot randomised controlled trial in infants and children requiring mechanical ventilation and receiving supplemental oxygen for abnormal gas exchange accepted for emergency admission to one of three participating UK PICUs. The study groups will be either a conservative SpO2 target of 88%–92% (inclusive) or a liberal SpO2 target of >94%. Infants and children who fulfil all inclusion criteria and none of the exclusion criteria will be randomised 1:1 by a secure web-based system to one of the two groups. Baseline demographics and clinical status will be recorded as well as daily measures of oxygenation and organ support. Discharge outcomes will also be recorded. In addition to observational data, blood and urine samples will be taken to identify biochemical markers of oxidative stress. Outcomes are targeted at assessing study feasibility with a primary outcome of adequate study recruitment (target: 120 participants).
Ethics and dissemination
The trial received Health Research Authority approval on 1 June 2017 (16/SC/0617). Study findings will be disseminated in national and international conferences and peer-reviewed journals.
Trial registration number
PMCID: PMC5736024  PMID: 29247112
child; critical care; hypoxia; hyperoxia
2.  Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definition 
Intensive Care Medicine  2016;42(12):1948-1957.
Although overall paediatric septic shock mortality is decreasing, refractory septic shock (RSS) is still associated with high mortality. A definition for RSS is urgently needed to facilitate earlier identification and treatment. We aim to establish a European society of paediatric and neonatal intensive care (ESPNIC) experts’ definition of paediatric RSS.
We conducted a two-round Delphi study followed by an observational multicentre retrospective study. One hundred and fourteen paediatric intensivists answered a clinical case-based, two-round Delphi survey, identifying clinical items consistent with RSS. Multivariate analysis of these items in a development single-centre cohort (70 patients, 30 % mortality) facilitated development of RSS definitions based on either a bedside or computed severity score. Both scores were subsequently tested in a validation cohort (six centres, 424 patients, 11.6 % mortality).
From the Delphi process, the draft definition included evidence of myocardial dysfunction and high blood lactate levels despite high vasopressor treatment. When assessed in the development population, each item was independently associated with the need for extracorporeal life support (ECLS) or death. Resultant bedside and computed septic shock scores had high discriminative power against the need for ECLS or death, with areas under the receiver operating characteristics curve of 0.920 (95 % CI 0.89–0.94), and 0.956 (95 % CI 0.93–0.97), respectively. RSS defined by a bedside score equal to or higher than 2 and a computed score equal to or higher than 3.5 was associated with a significant increase in mortality.
This ESPNIC definition of RSS accurately identifies children with the most severe form of septic shock.
Electronic supplementary material
The online version of this article (doi:10.1007/s00134-016-4574-2) contains supplementary material, which is available to authorized users.
PMCID: PMC5106490  PMID: 27709263
Shock; Septic; Paediatrics; Acidosis; Lactic; Resuscitation; Failure; Cardiac
4.  Survey of Oxygen Delivery Practices in UK Paediatric Intensive Care Units 
Purpose. Administration of supplemental oxygen is common in paediatric intensive care. We explored the current practice of oxygen administration using a case vignette in paediatric intensive care units (PICU) in the united kingdom. Methods. We conducted an online survey of Paediatric Intensive Care Society members in the UK. The survey outlined a clinical scenario followed by questions on oxygenation targets for 5 common diagnoses seen in critically ill children. Results. Fifty-three paediatric intensive care unit members from 10 institutions completed the survey. In a child with moderate ventilatory requirements, 21 respondents (42%) did not follow arterial partial pressure of oxygen (PaO2) targets. In acute respiratory distress syndrome, cardiac arrest, and sepsis, there was a trend to aim for lower PaO2 as the fraction of inspired oxygen (FiO2) increased. Conversely, in traumatic brain injury and pulmonary hypertension, respondents aimed for normal PaO2 even as the FiO2 increased. Conclusions. In this sample of clinicians PaO2 targets were not commonly used. Clinicians target lower PaO2 as FiO2 increases in acute respiratory distress syndrome, cardiac arrest, and sepsis whilst targeting normal range irrespective of FiO2 in traumatic brain injury and pulmonary hypertension.
PMCID: PMC4969506  PMID: 27516901
5.  French Intensive Care Society, International congress – Réanimation 2016 
Jaillette, Emmanuelle | Girault, Christophe | Brunin, Guillaume | Zerimech, Farid | Chiche, Arnaud | Broucqsault-Dedrie, Céline | Fayolle, Cyril | Minacori, Franck | Alves, Isabelle | Barrailler, Stephanie | Robriquet, Laurent | Delaporte, Emmanuel | Thellier, Damien | Delcourte, Claire | Duhamel, Alain | Nseir, Saad | Valette, Xavier | Desmeulles, Isabelle | Savary, Benoit | Masson, Romain | Seguin, Amélie | Daubin, Cédric | Sauneuf, Bertrand | Verrier, Pierre | Pottier, Véronique | Orabona, Marie | Samba, Désiré | Viquesnel, Gérald | Lermuzeaux, Mathilde | Hazera, Pascal | Hanouz, Jean-Luc | Parienti, Jean-Jacques | Du Cheyron, Damien | Demoule, Alexandre | Clavel, Marc | Rolland-Debord, Camille | Perbet, Sébastien | Terzi, Nicolas | Kouatchet, Achille | Wallet, Florent | Roze, Hadrien | Vargas, Frédéric | Guérin, Claude | Dellamonica, Jean | Jaber, Samir | Similowski, Thomas | Quenot, Jean-Pierre | Binquet, Christine | Vinsonneau, Christophe | Barbar, Saber-Davide | Vinault, Sandrine | Deckert, Valérie | Lemaire, Stephanie | Hssain, Ali Ait | Bruyère, Rémi | Souweine, Bertrand | Lagrost, Laurent | Adrie, Christophe | Jung, Boris | Daurat, Aurelien | De Jong, Audrey | Chanques, Gérald | Mahul, Martin | Monnin, Marion | Molinari, Nicolas | Lheureux, Olivier | Trepo, Eric | Hites, Maya | Cotton, Frederic | Wolff, Fleur | Surin, Rudy | Créteur, Jacques | Vincent, Jean-Louis | Gustot, Thierry | Jacobs, Frederique | Taccone, Fabio Silvio | Neuville, Mathilde | Timsit, Jean-François | El-Helali, Najoua | Le Monnier, Alban | Magalhaes, Eric | Radjou, Aguila | Smonig, Roland | Soubirou, Jean-François | Voiriot, Guillaume | Sonneville, Romain | Bouadma, Lila | Mourvillier, Bruno | Gélisse, Elodie | Brasseur, Alexandre | Roisin, Sandrine | De Backer, Daniel | Van Ruychevelt, Valerie | Carlier, Eric | Piagnerelli, Michael | Vanhaeverbeek, Michel | Danguy, Christine | Biston, Patrick | Au, Siu-Ming | Begot, Emmanuelle | Dalmay, François | Repessé, Xavier | Prat, Gwenael | Bouferrache, Koceila | Slama, Michel | Vieillard-Baron, Antoine | Monnet, Xavier | Marik, Paul | Teboul, Jean-Louis | Jozwiak, Mathieu | Richard, Christian | Chauvet, Jean-Louis | El-Dash, Shari | Delastre, Olivier | Bouffandeau, Bernard | Jusserand, Dominique | Michot, Jean-Baptiste | Bauer, Fabrice | Brazier, François | Mercado, Pablo | Kontar, Loay | Titeca, Dimitri | De Cagny, Bertand | Bacari-Risal, Gaelle | Riviere, Antoine | Maizel, Julien | Guillot, Camille | Le Reun, Claire | Lampin, Marie | Sadik, Ahmed | Botte, Astrid | Leteurtre, Stéphane | Collins, Aurélie | Kempeneers, Céline | Cajgfinger, Nathalie | Ohlmann, Camille | Pouyau, Robin | Subtil, Fabien | Baudin, Florent | Massenavette, Bruno | Javouhey, Etienne | Milesi, Christophe | Essouri, Sandrine | Liet, Jean-Michel | Afanetti, Mickael | Durand, Sabine | Durand, Philippe | Roze, Jean Christophe | Dupont, Didier | Cambonie, Gilles | Soyer, Benjamin | Rusca, Marco | Lukaszewicz, Anne-Claire | Crassard, Isabelle | Guichard, Jean-Pierre | Bresson, Damien | de la Garanderie, Didier Payen | Cantier, Marie | Sabben, Candice | Louedec, Liliane | Delbosc, Sandrine | Journé, Clément | Ou, Phalla | Klein, Isabelle | Chau, Françoise | Lefort, Agnes | Desilles, Jean-Philippe | Michel, Jean-Baptiste | Mazighi, Mikaël | Salem, Omar Ben Hadj | Demeret, Sophie | Bolgert, Francis | Sharshar, Tarek | Grabli, David | Arib, Safa | Crippa, Ilaria Alice | Soummer, Alexis | Engrand, Nicolas | Guedin, Pierre | Aldea, Sorin | Cerf, Charles | Desailly, Victoire | Pasquier, Pierre | Brun, Patrick | Roux, Damien | Latournerie, Gwendoline | Kasprzyk, Laetitia | Grosjean, Vincent | Latreche, Amine | Habert, Pierre | Huot, Stephane | Jobin, Timon | Tesnière, Antoine | Dreyfuss, Didier | Ricard, Jean-Damien | Mignon, Alexandre | Gaudry, Stéphane | Laithier, François-Xavier | Kimmoun, Antoine | Chouihed, Tahar | Albizzati, Stéphane | Camenzind, Edoardo | Vanhuyse, Fabrice | Levy, Bruno | Cour, Martin | Venet, Fabienne | Hernu, Romain | Demaret, Julie | Monneret, Guillaume | Argaud, Laurent | Dumas, Florence | Lamhaut, Lionel | Rosencher, Julien | Pène, Frédéric | Varenne, Olivier | Carli, Pierre | Jouven, Xavier | Spaulding, Christian | Cariou, Alain | Geri, Guillaume | Bonnetain, Franck | Marijon, Eloi | Empana, Jean Philippe | Mirouse, Adrien | Resche-Rigon, Matthieu | Mayaux, Julien | Rabbat, Antoine | Meert, Anne Pascale | Benoit, Dominique | Bruneel, Fabrice | Azoulay, Elie | Dupuis, Claire | Schwebel, Carole | Ruckly, Stéphane | Goldgran-Toledano, Dany | Marcotte, Guillaume | Lafarge, Antoine | Pichereau, Claire | Theodose, Igor | Scotto, Marion | Kemlin, Delphine | Ghrenassia, Etienne | Schlemmer, Benoît | Vimpere, Damien | Galicier, Lionel | Contou, Damien | Guérot, Emmanuel | Grimaldi, David | Ricome, Sylvie | Maury, Eric | Plantefève, Gaëtan | Dessap, Armand Mekontso | Brun-Buisson, Christian | de Prost, Nicolas | Dubé, Bruno-Pierre | Delemazure, Julie | Dres, Martin | Rousseau, Ludivine | Drouot, Xavier | Diaz, Véronique | Rebollar, Yohann | Frat, Jean-Pierre | Thille, Arnaud W. | Aissa, Dalinda Ait | Coquet, Pierre | Ruiz, Jean | Ferre, Fabrice | Hoarau, Lucille | Riu-Poulenc, Béatrice | Bataille, Benoit | Silva, Stein | Baudel, Jean-Luc | Bigé, Naïke | Tahiri, Jalel | Dubée, Vincent | Guidet, Bertrand | Ait-Oufella, Hafid | Jinglun, Liu | Shen, Feng | Monnet, Xavier | Bailly, Sébastien | Leroy, Olivier | Montravers, Philippe | Constantin, Jean-Michel | Dupont, Hervé | Guillemot, Didier | Lortholary, Olivier | Perrigault, Pierre-François | Gangneux, Jean-Pierre | Razazi, Keyvan | Mekontso-Dessap, Armand | Jansen, Chloe | Lecronier, Marie | Sandrine, Valade | Mira, Jean-Paul | Blein, Sophie | Marin, Nathalie | Rousseau, Christophe | Charpentier, Julien | Pachot, Alexandre | Hraiech, Sami | Bordes, Julien | De, Lamballerie Xavier | Mège, Jean-Louis | Forel, Jean-Marie | Guervilly, Christophe | Adda, Mélanie | Raoult, Didier | Papazian, Laurent | Kentish-Barnes, Nancy | Cohen-Solal, Zoé | Kentish-Barnes, Nancy | Souppart, Virginie | Kerhuel, Lionel | Haubertin, Carole | Exbrayat, Isabelle | Rozières, Elodie | Argain, Audrey | Suc, Agnès | Vignes, Michel | Cougot, Pierre | Fourcade, Olivier | Brunel, Elodie | Messika, Jonathan | Tubach, Florence | Dubief, Emeline | Pasquet, Blandine | Guillo, Sylvie | Pierron, Charlotte | Grimaud, Marion | Farnoux, Caroline | Maillard, Amélie | Decavèle, Maxens | Prodanovic, Hélène | Idbaih, Ahmed | Alentorn, Agusti | Delattre, Jean-Yves | De Montmollin, Etienne | Brule, Noelle | Conrad, Marie | Dailler, Frédéric | Navellou, Jean-Christophe | Alves, Mikael | Tonnelier, Jean-Marie | Ruckly, Stephane | Picard, Géraldine | Rogemond, Véronique | Honnorat, Jérôme | Marzorati, Chiara | Lebert, Christine | Perez, Pierre | Citerio, Giuseppe | Legriel, Stéphane | Tripon, Simona | Mallet, Maxime | Rudler, Marika | Imbert-Bismut, Francoise | Thabut, Dominique | Canet, Emmanuel | Faguer, Stanislas | Moreau, Anne-Sophie | Barbier, François | Merceron, Sybille | Guitton, Christophe | Labadie, Francois | Lemiale, Virginie | Faucher, Etienne | Klouche, Kada | Chevret, Sylvie | Ragot, Stéphanie | Coudroy, Remi | Boulain, Thierry | Jamet, Angéline | Mercat, Alain | Brochard, Laurent | Roux, Antoine | Lemiale, Virginie | Franchineau, Guillaume | Brechot, Nicolas | Lebreton, Guillaume | Hekimian, Guillaume | Nieszkowska, Ania | Leprince, Pascal | Trouillet, Jean Louis | Combes, Alain | Schmidt, Matthieu | Barrot, Loïc | Piton, Gaël | Bailey, Michael | Panwar, Rakshit | Belin, Nicolas | Belon, François | Patry, Cyrille | Grandperrin, Mathilde | Chaignat, Claire | Labro, Guylaine | Vivet, Bérengère | Capellier, Gilles | Daix, Thomas | Guérin, Estelle | Tavernier, Elsa | Mercier, Emmanuelle | Gissot, Valérie | Vallejo, Christine | François, Bruno | Ravry, Céline | Pichon, Nicolas | Chapellas, Catherine | Fedou, Anne-Laure | Galy, Antoine | Ploy, Marie-Cécile | Barraud, Olivier | Vignon, Philippe | Thooft, Aurelie | Conotte, Raphael | Colet, Jean-Marie | Le Dorze, Matthieu | Tarazona, Virginie | Brumpt, Caren | Moins-Teisserenc, Hélène | Uhel, Fabrice | Azzaoui, Imane | Gregoire, Murielle | Pangault, Céline | Dulong, Joëlle | Cynober, Luc | Roussel, Mikaël | Le Tulzo, Yves | Tarte, Karin | Demiselle, Julien | Auchabie, Johann | Dequin, Pierre François | Chudeau, Nicolas | Fourrier, François | Grange, Steven | Piquilloud, Lise | Lautrette, Alexandre | Boyer, Sonia | Letheulle, Julien | Lerolle, Nicolas | Truche, Anne Sophie | Clec’h, Christophe | Zaoui, Philippe | Laurent, Virginie | Toledano, Dany Goldgran | Ragey, Sophie Perinel | Gros, Antoine | Dumenil, Anne Sylvie | Jamali, Samir | Darmon, Michaël | Chouraqui, Mikhael | Dewitte, Antoine | Chastel, Brigitte | Carles, Pauline | Fleureau, Catherine | Joannes-Boyau, Olivier | Ouattara, Alexandre | Joseph, Adrien | Garrouste-Orgeas, Maïté | Max, Adeline | Lerin, Talia | Grégoire, Charles | Kloeckner, Martin | Bruel, Cédric | Brochon, Sandie | Philippart, Francois | Pichot, Emmanuelle | Simons, Clara | Flint, Andrew | Aubron, Cécile | Bellomo, Rinaldo | Pilcher, David | Cheng, Allen | Hegarty, Colin | Martinelli, Anthony | Howden, Benjamin | Reade, Michael | Mcquilten, Zoe | Bretonnière, Cédric | Villers, Daniel | Soares, M. | Gonzalez, Frédéric | Vincent, François | Fauché, Clémence | Gay, Samuel | Skowron, Olivier | Levrat, Albrice | Dorez, Didier | Decavèle, Maxens | Foucrier, Arnaud | Pease, Sebastian | Gauss, Tobias | Paugam, Catherine | Gorham, Julie | Ameye, Lieveke | Paesmans, Marianne | Berghmans, Thierry | Sculier, Jean-Paul | Meert, Anne-Pascale | Deras, Pauline | Martinez, Orianne | Latry, Pascal | Capdevila, Xavier | Charbit, Jonathan | Jaubert, J. | Etiennar, Celia | Ginoux, Lucie | Sebbah, Jean-Luc | Haouache, Hakim | Dhonneur, Gilles | Cheikh, Chaigar Mohammed | Moussaid, I. | Ghazaoui, O. | Belkadi, Kamal | El Youssoufi, S. | Salmi, S. | Pajot, Laure | Zuber, Benjamin | Darmon, Michael | Bedos, Jean Pierre | Dupont, Benoit | Eugène, Axelle | Galateau-Sallé, Françoise | Michard, Baptiste | Lebas, Benjamin | Boivin, Alexandra | Guillot, Max | Harlay, Marie-Line | Janssen-Langenstein, Ralf | Schenck, Maleka | Ellero, Bernard | Woehl-Jaegle, Marie-Lorraine | Besch, Camille | Castelain, Vincent | Bachellier, Philippe | Schneider, Francis | Camus, Christophe | Saliba, Fawzi | Goubaux, Bernard | Bonadona, Agnès | Lavayssiere, Laurence | Quinart, Alice | Barbot, Olivier | Dharancy, Sebastien | Delafosse, Bertrand | Barraud, Helene | Galbois, Arnaud | Veber, Benoit | Cayot, Sophie | Souche, Bruno | Locher, Clara | Roux, Olivier | Figorilli, Francesco | Putignano, Antonella | Houssel, Pauline | Francoz, Claire | Weiss, Emmanuel | Agarwal, Banwari | Jalan, Rajiv | Durand, François | Ghezala, Hassen Ben | Daoudi, Rebeh | Kaddour, Moez | Ghadhoune, Hatem | Rachedi, E. | Guissouma, J. | Ben Slimene, A. | Azzeza, W. | Brahmi, H. | Elghord, H. | Kada, Ahmed Youssef | Chikh, Radia | Slimani, Roza | a Bouyoucef, Kheireddine. | Regaieg, Kais | Kamilia, Chtara | Baccouche, Najeh | Turki, Olfa | Chaari, Anis | Ben, Hmida Chokri | Bouaziz, Mounir | Medhioub, Fatma Kaaniche | Zekri, Manel | Rgieg, Kais | Bhimada, Chokri | Mounir, Bouaziz | Cheikh, Chaigar Mohammed | Lang, Elodie | Welschbillig, Stephane | Perrin, Mathilde | Devys, Jean-Michel | Benbernou, Soumia | Mokhtari-Djebli, Houria | Ilies, Sofiane | Bouyacoub, Khalida | Azza, Abdelkader | Zogheib, Elie | Nader, Joseph | Villeret, Léonie | Guilbart, Mathieu | Besserve, Patricia | Caus, Thierry | Mastroianni, Ciro | Santi, Francesca | Hékimian, Guillaume | Pascal, Leprince | Chastre, Jean | Perrier, Virginie | Deniau, Benjamin | Klasen, Fanny | Ponthus, Jean Pierre | Ngasseu, Polysie | Amilien, Virginie | Barsam, Elise | Lehericey, Pierre | Tchir, Martial | Georger, Jean Francois | Puech, Bérénice | Vandroux, David | Roussiaux, Arnaud | Belcour, Dominique | Ferdynus, Cyril | Martinet, Olivier | Jabot, Julien | Fresco, Marion | Demeilliers-Pfister, Gaëlle | Merle, Véronique | Brunel, Valéry | Dureuil, Bertrand | Leydier, Sébastien | Clerc-Urmes, Isabelle | Lemarie, Jérémie | Maigrat, Charles-Henri | Cravoisy-Popovic, Aurélie | Barraud, Damien | Nace, Lionel | Gibot, Sébastien | Agrinier, Nelly | Bollaert, Pierre-Edouard | Daban, Jean-Louis | Boutonnet, Mathieu | Dumas, Guillaume | Falzone, Elisabeth | Jault, Patrick | Lenoir, Bernard | Makunza, Joseph Nsiala | Mejeni, Nathalie | Mazaud, Amélie | Béague, Sébastien | Rousselle, Anne-Flore | Durocher, Alain | Perez, Pauline | Grinea, Alexandra | Bedoui, Naoures | Stoian, Alina | Baboi, Loredana | Gobert, Florent | Yonis, Hodane | Tapponier, Romain | Bruyneel, Arnaud | Bonus, Thierry | Cuvelier, Grégory | Machayeckhi, Sharam | Olieuz, Sandra | Legrand, Alexandre | Feki, Fatma | Jamoussi, Amira | Merhebene, Takoua | Braham, Emna | Ghariani, Asma | Mezni, Faouzi El | Slim, Leila | Khelil, Jalila Ben | Besbes, Mohamed | Marchalot, Antoine | Beduneau, Gaetan | Carpentier, Dorothée | Besnier, Emmanuel | Gastaldi, Gioia | Abily, Julien | Beuzelin, Marion | Nay, Mai-Anh | Mankikian, Julie | Hervé, Virginie | Soulie, Marie | Cronier, Pierrick | Kantor, Elie | Federici, Laura | Gilbert, Marion | Mezhari, Ilham | Choukroun, Gérald | Marque, Sophie | Coppere, Z. | Fulgencio, Jean-Pierre | Blayau, Clarisse | Pham, Tai | Djibre, Michel | Reffienna, Matthieu | Lefort, Sébastien | Debue, Anne-Sophie | Daviaud, Fabrice | Cabon, Sarah | Addou, Zakaria | Douah, Ali | Moussati, Mohamed | Belhabiche, Kamel | Aouffen, Nabil | Soulier, Sylvie | Mauriat, Philippe | Tafer, Nadir | Mortamet, Guillaume | Amaddeo, Alessandro | Khirani, Sonia | Fauroux, Brigitte | Khanes, Gennadiy | Liutko, Olga | Bidnenko, Svitlana | Doye, Emilie | Voirin, Nicolas | Maucort-Boulch, Delphine | Kolev-Descamp, Karine | Aouane, Imane El | Essid, Aben | Hammami, Wallid | Haegy, Isabelle | Bataille, Jacques | Bergounioux, Jean | Morin, Luc | Ray, Samiran | Maclaren, Graeme | Nadel, Simon | Kneyber, Martin | Peters, Mark | Jansen, Koos | De Luca, Daniele | Wilson, Clare | Schlapbach, Luregn | Tissières, Pierre | Girard, Anne-Claire | Savajols, Elodie | Burguet, Antoine | Semama, Denis | Litzler-Renault, Stephanie | Fredj, Hana | Hassouna, Malek | Hechmi, Youssef Zied El | Cherif, Mohamed Ali | Zouheir, Jerbi | Dernane, Ahmed | Bouakkaz, Fouad | Taleb, Lhoucine Ben | Zeddine Mouhsen, A. | Lyazidi, Aissam | Richard, Jean-Christophe Marie | Mouhsen, Ahmed | Harmouchi, Mohammed | Rattal, Mourad | Huck, Matthias | Leclerc, Thomas | Donat, Nicolas | Cirodde, Audrey | Schaal, Jean-Vivien | Masson, Yannick | Hoffmann, Clément | Cerland, Laura | Valentino, Ruddy | Chabartier, C. | Villain-Coquet, Laurent | Ferge, Jean-Louis | Brouste, Y. | Mehdaoui, Hossein | Louriz, Maha | Madani, Naoufal | Amlaiky, Fatiha | Dendane, Tarek | Abidi, Khalid | Zekraoui, Aicha | Zeggwagh, Amine Ali | Abouqal, Redouane | Brahim, Affra | Ferhi, Fehmi | Bouslama, Mohamed Amine | Benjazia, Khaled | Zeineb, Abid | Mahassen, Dhaouadi | Cadiet, Julien | Ferron, Marine | Prat, Valentine | Erraud, Angelique | Aillerie, Virginie | Mevel, Mathieu | Grabherr, Amandine | Chatham, John C. | Gauthier, Chantal | Lauzier, Benjamin | Rozec, Bertrand | Joffre, Jeremie | Loyer, Xavier | Lavillegrand, Jean-Rémi | Zeboudj, Lynda | Laurans, Ludivine | Esposito, Bruno | Tedgui, Alain | Mallat, Ziad | Wei, Chaojie | Kattani, Narimane Al | Louis, Huguette | Orlowski, Sophie | Tharaux, Pierre-Louis | Burban, Mélanie | Meyer, Grégory | Olland, Anne | Yver, Blandine | Toti, Florence | Schini-Kerth, Valérie | Monnier, Alexandra | Leborgne, Pierrick | Meziani, Ferhat | Clavier, Thomas | Paulus, Mulder | Castel, Hélène | Richard, Vincent | Pons, Stéphanie | Skurnik, David | Six, Sophie | Jaffal, Karim | Vigneron, Clara | Large, Audrey | Bador, Julien | Aho, Serge | Prin, Sebastien | Touil, Yosr | Ayed, Soufia | Ali, Habiba Sik | Tilouch, Najla | Mateur, Houda | Talik, I. | Gharbi, Rim | Hassen, Mohamed Fekih | Elatrous, Souheil | Patry, Isabelle | Bertrand, Xavier | Zahar, Jean-Ralph | Essaied, Wafa | Wolkewitz, Martin | Soued, Mickaël | Cook, Fabrice | Lobo, David | Mounier, Roman | Emirian, Aurélie | Decousser, Jean Winoc | Slaoui, Mohamed Toufik | Benslama, Abdellatif | Valance, Dorothée | Allou, Nicolas | Allyn, Jérôme | Jean-Bart, Elodie | Bel., Floriane | Morey, Fabienne | Sedillot, Nicholas | Biard, Lucie | Galliot, Richard | Zunarelli, Romain | Gauzere, Bernard-Alex | Cartier, Jean-Charles | Jouve, Thomas | Hilleret, Marie-Noëlle | Hamidfar-Roy, Rebecca | Ara-Somohano, Claire | Minet, Clémence | Pourcelet, Aline | Hougardy, Jean-Michel | Defrance, Pierre | De Laforcade, Louis | Boyer, Alexandre | Gruson, Didier | Clouzeau, Benjamin | Hajjam, Najah | Nasri, Houda | Doghri, Hamdi | Mongardon, Nicolas | Levesque, Eric | Bastide, Marie-Anaïs | Richecoeur, Jack | Frenoy, Eric | Lemaire, Christian | Schortgen, Frédérique | Preau, Sebastien | Ehooman, Franck | Montlahuc, Claire | Bardon, Jean | Postel-Vinay, Nicolas | Lafi, Mehdi | Jacobs, Frédéric | Prat, Dominique | Le Meur, Matthieu | Moneger, Guy | Demars, Nadège | Trouiller, Pierre | Tencé, Noémie | Zaien, Inès | Wolf, Martine | Allardet-Servent, Jérôme | Lebsir, Melissa | Dubroca, Christian | Portugal, Mireille | Castanier, Matthias | Signouret, Thomas | Soundaravelou, Rettinavelou | Lepidi, Anne | Halfon, Philippe | Seghboyan, Jean-Marie | Gamblin, Camille | Benturquia, Nadia | Roussel, Olivier | Chevillard, Lucie | Risede, Patricia | Callebert, Jacques | Khelfa, Messaouda | Blel, Youssef | Thabet, H. | Brahmi, Nozha | Amamou, M. | Le Louët, A. Lillo- | Baud, F. | Le Beller, C. | Vivien, B. | Soufir, L. | Carli, P. | Le Louët, H. | Essafi, Fatma | Foudhaili, Nasreddine | Slimen, Abdelaziz Ben | Jabla, Rami | Hammed, Hedia | Marzouk, Mahdi | Boujelbene, Nesrine | Dachraoui, Fahmi | Hachani, Asma | Abdallah, Saousen Ben | Lakhal, Hend Ben | Ghribi, Chaima | Ali, Imen Ben | Abdellaoui, Imen | Ouanes-Besbes, Lamia | Abroug, Fekri | Demiri, Suela | Lorut, Christine | Van Lang, Daniel Luu | Lefebvre, Aurélie | Alifano, Marco | Reignard, Jean-Francois | Samama, Marc | Dusser, Daniel | Roche, Nicolas | Réminiac, François | Landel, Cassandre | Gensburger, Samuel | Bocar, Thomas | Mordier, Lydiane | Philippe, Marion | Le Pennec, Déborah | Vecellio, Laurent | Ehrmann, Stephan | Poiroux, Laurent | Thevoz, David | Simons, Julien | Roeseler, Jean | Loiez, Anthéa | Gérard, Stéphanie | Dousse, Nicolas | L’hotellier, Sylvie | Baumgarten, Elodie | Borschneck, Stéphanie | Kharcha, Fatima | Ghander, Cécile | Tresallet, Christophe | Puymirat, Etienne | Fagon, Jean-Yves | Aegerter, Philippe | Diehl, Jean-Luc | Hauw-Berlemont, Caroline | Chatellier, Gilles | Danchin, Nicolas | Aissaoui, Nadia | Aissat, Nadia | Bernard, R. | Amour, Julien | Bouglé, Adrien | Vidal, Charles | Nima, Djavidi | Shaida, Varnous | Dorget, Amandine | Bréchot, Nicolas | Toufiki, Rabi | Mouaffak, Youssef | Adib, Ahmed Rhassan El | Amine, M. | Moumine, S. | Jonard, Marie
Annals of Intensive Care  2016;6(Suppl 1):50.
Table of contents
O1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized controlled study (BEST CUFF)
Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacori, Isabelle Alves, Stephanie Barrailler, Laurent Robriquet, Fabienne Tamion, Emmanuel Delaporte, Damien Thellier, Claire Delcourte, Alain Duhamel, Saad Nseir
O2 Bicarbonate versus saline for contrast-induced acute kidney injury prevention in critically ill patients
Xavier Valette, Isabelle Desmeulles, Benoit Savary, Romain Masson, Amélie Seguin, Cédric Daubin, Bertrand Sauneuf, Jennifer Brunet, Pierre Verrier, Véronique Pottier, Marie Orabona, Désiré Samba, Gérald Viquesnel, Mathilde Lermuzeaux, Pascal Hazera, Jean-Luc Hanouz, Jean-Jacques Parienti, Damien Du Cheyron
O3 Neurally adjusted ventilatory assist in the early phase of weaning from mechanical ventilation: a multicenter randomized study
Alexandre Demoule, Marc Clavel, Camille Rolland-Debord, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Florent Wallet, Hadrien Roze, Frédéric Vargas, Claude Guérin, Jean Dellamonica, Samir Jaber, Thomas Similowski
O4 Very high volume hemofiltration with the Cascade system in septic shock patients
Jean-Pierre Quenot, Christine Binquet, Christophe Vinsonneau, Saber-Davide Barbar, Sandrine Vinault,, Valérie Deckert, Stephanie Lemaire, Ali Ait Hssain, Rémi Bruyère, Bertrand Souweine, Laurent Lagrost, Christophe Adrie
O5 Effect of rapid response systems on hospital mortality, a prospective interventional study and systematic review
Boris Jung, Aurelien Daurat, Audrey De Jong, Gérald Chanques, Martin Mahul,, Marion Monnin, Nicolas Molinari, Samir Jaber
O6 Beta-lactams serum concentrations in critically ill cirrhotic patients: a matched control study
Olivier Lheureux, Eric Trepo, Maya Hites, Frederic Cotton, Fleur Wolff, Rudy Surin, Jacques Créteur, Jean-Louis Vincent, Thierry Gustot, Frederique Jacobs, Fabio Silvio Taccone
O7 Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: Risk factors and side effects
Mathilde Neuville, Jean-François Timsit, Najoua El-Helali, Alban Le Monnier, Eric Magalhaes, Aguila Radjou, Roland Smonig, Jean-François Soubirou, Guillaume Voiriot, Romain Sonneville, Lila Bouadma, Bruno Mourvillier
O8 Amikacin peak concentrations in patients receiving extracorporeal membrane oxygenation (ECMO) support: a case–control study
Elodie Gélisse, Mathilde Neuville, Etienne De Montmollin, Guillaume Voiriot, Jean-François Soubirou, Roland Smonig, Aguila Radjou, Eric Magalhaes, Lila Bouadma, Bruno Mourvillier, Jean-François Timsit, Romain Sonneville
O9 A high aminoglycoside regimen associated with renal replacement therapy for the treatment of multi-drug-resistant pathogens
Alexandre Brasseur, Maya Hites, Sandrine Roisin, Frederic Cotton, Jean-Louis Vincent, Daniel De Backer, Frederique Jacobs, Fabio Silvio Taccone
O10 Optimization of administration of vancomycin in septic patients: a prospective randomized study
Valerie Van Ruychevelt, Eric Carlier, Michael Piagnerelli, Michel Vanhaeverbeek, Christine Danguy, Patrick Biston
O11 Impact of elevated intra-abdominal pressure on the ability of dynamic parameters to predict fluid responsiveness
Siu-Ming Au, Emmanuelle Begot, François Dalmay, Xavier Repessé, Gwenael Prat, Koceila Bouferrache, Michel Slama, Philippe Vignon, Antoine Vieillard-Baron
O12 Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis
Xavier Monnet, Paul Marik, Jean-Louis Teboul
O13 Predicting volume responsiveness by using combined end-expiratory and end-inspiratory occlusion tests with echocardiography
Mathieu Jozwiak, Jean-Louis Teboul, Christian Richard, Xavier Monnet
O14 Early dynamic left intraventricular obstruction is associated with hypovolemia and hight mortality in septic shock patients
Jean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, Julien Maizel, Michel Slama
O15 Predictive factors for poor hemodynamic tolerance to fluid removal in ICU: the DepleRea study
François Brazier, Pablo Mercado, Loay Kontar, Dimitri Titeca, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien Maizel
O16 High-flow nasal cannula: first-line treatment of noninvasive ventilation for infants with bronchiolitis. Applicability and risk factors for failure
Camille Guillot, Claire Le Reun, Marie Lampin, Ahmed Sadik, Astrid Botte, Alain Duhamel, Stéphane Leteurtre
O17 Is high-flow nasal cannula better than nasal continuous positive airway pressure for bronchiolitis management in pediatric intensive care unit?
Aurélie Collins, Céline Kempeneers, Nathalie Cajgfinger
O18 Interest and risk of high-flow cannula during acute hypoxemic pneumonia in children: a retrospective study
Camille Ohlmann, Robin Pouyau, Fabien Subtil, Florent Baudin, Bruno Massenavette, Etienne Javouhey
O19 Interest of high-flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) during the initial management of severe bronchiolitis in infants: a multicenter randomized controlled trial
Christophe Milesi, Sandrine Essouri, Robin Pouyau,, Jean-Michel Liet, Mickael Afanetti, Julien Baleine, Sabine Durand, Philippe Durand, Etienne Javouhey, Jean Christophe Roze, Didier Dupont, Gilles Cambonie
O20 Outcome of severe cerebral venous thrombosis in intensive care unit: a cohort study
Benjamin Soyer, Marco Rusca, Anne-Claire Lukaszewicz, Isabelle Crassard, Jean-Pierre Guichard, Damien Bresson, Didier Payen de la Garanderie
O21 Brain lesion spectrum characterization in an experimental model of infective endocarditis
Marie Cantier, Candice Sabben, Liliane Louedec, Sandrine Delbosc, Clément Journé, Phalla Ou, Isabelle Klein, Françoise Chau, Agnes Lefort, Jean-Philippe Desilles, Jean-Baptiste Michel, Romain Sonneville, Mikaël Mazighi
O22 Outcome of patients with Parkinson’s disease admitted in intensive care unit
Omar Ben Hadj Salem, Sophie Demeret, Alexandre Demoule, Thomas Similowski, Francis Bolgert, Tarek Sharshar, David Grabli
O23 Cerebrospinal fluid glucose and lactate concentrations after subarachnoid hemorrhage
Safa Arib, Ilaria Alice Crippa, Jacques Créteur, Jean-Louis Vincent, Fabio Silvio Taccone
O24 Spontaneous angionegative subarachnoidal hemorrhage: neurological outcome based on a retrospective study of 68 patients
Alexis Soummer, Nicolas Engrand, Pierre Guedin, Grégoire Trebbia, Sorin Aldea, Charles Cerf
O25 Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders
Victoire Desailly, Pierre Pasquier, Patrick Brun, Damien Roux, Jonathan Messika, Gwendoline Latournerie, Laetitia Kasprzyk, Vincent Grosjean, Amine Latreche, Pierre Habert, Stephane Huot, Timon Jobin, Antoine Tesnière, Didier Dreyfuss, Jean-Damien Ricard, Alexandre Mignon, Stéphane Gaudry
O26 Refractory out-of-hospital refractory cardiac arrest treated by veno-arterial extracorporeal membrane oxygenation. A retrospective single-center experience from 2012 to 2015. CARECMO program (Cardiac ARrest Extra Corporeal Membrane Oxygenation)
François-Xavier Laithier, Antoine Kimmoun, Tahar Chouihed, Stéphane Albizzati, Edoardo Camenzind, Fabrice Vanhuyse, Bruno Levy
O27 Decreased monocyte HLA-DR expression after out-of-hospital cardiac arrest
Martin Cour, Fabienne Venet, Romain Hernu, Julie Demaret, Guillaume Monneret, Laurent Argaud
O28 Is emergent PCI associated with a clinical benefit in post-cardiac arrest patients without ST-segment elevation pattern? Insights from the PROCAT II registry
Florence Dumas, Wulfran Bougouin, Guillaume Geri, Lionel Lamhaut, Julien Rosencher, Frédéric Pène, Jean-Daniel Chiche, Olivier Varenne, Pierre Carli, Xavier Jouven, Jean-Paul Mira, Christian Spaulding, Alain Cariou
O29 Predictors of long-term quality of life after cardiac arrest: insights from the Parisian registry
Guillaume Geri, Florence Dumas, Franck Bonnetain,, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Pierre Carli, Eloi Marijon, Olivier Varenne, Jean-Paul Mira, Jean Philippe Empana, Alain Cariou
O30 Red blood cell transfusions in early resuscitation of severe sepsis and septic shock in patients with hematological malignancies
Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, François Vincent, Julien Mayaux, Antoine Rabbat, Martine Nyunga, Anne Pascale Meert, Dominique Benoit, Achille Kouatchet, Michaël Darmon, Fabrice Bruneel, Elie Azoulay, Frédéric Pène
O31 Causal effect of transfusion on mortality and other adverse events among critically ill septic patients: an observational study with a marginal structural model
Claire Dupuis, Michaël Darmon, Carole Schwebel, Elie Azoulay, Romain Sonneville, Lila Bouadma, Roland Smonig, Yves Cohen, Stéphane Ruckly, Christophe Adrie, Dany Goldgran-Toledano, Sébastien Bailly, Guillaume Marcotte, Maïté Garrouste-Orgeas, Jean-François Timsit
O32 Autoimmune hemolytic anemia in the intensive care unit
Antoine Lafarge, Claire Pichereau, Sandrine Valade, Marion Venot, Akli Chermak, Igor Theodose, Marion Scotto, Delphine Kemlin, Claire Givel, Leïla Mourtada, Etienne Ghrenassia, Emmanuel Canet, Virginie Lemiale, Benoît Schlemmer, Elie Azoulay, Eric Mariotte
O33 Pre-ICU location, lead time bias and outcomes in patients with thrombotic microangiopathies
Damien Vimpere, Sandrine Valade, Marion Venot, Claire Pichereau, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Lionel Galicier, Elie Azoulay, Eric Mariotte
O34 Septic shocks with no early etiological diagnosis: a multicenter prospective cohort study (the shock 24 study)
Damien Contou, Damien Roux, Sebastien Jochmans, Remi Coudroy, Emmanuel Guérot, David Grimaldi, Sylvie Ricome, Eric Maury, Gaëtan Plantefève, Julien Mayaux, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost
O35 Respective contribution of diaphragm and limbs muscles weakness on weaning from mechanical ventilation outcome
Alexandre Demoule, Bruno-Pierre Dubé, Julien Mayaux, Julie Delemazure, Thomas Similowski, Martin Dres
O36 Impact of sleep quality on the duration of weaning from mechanical ventilation
Ludivine Rousseau, Xavier Drouot, Véronique Diaz, Yohann Rebollar, Jean-Pierre Frat, Remi Coudroy, René Robert, Arnaud, W Thille, Groupe ALIVE
O37 Integrative ultrasound assessment of lung, cardiac and diaphragm function during a successful weaning trial predicts postextubation distress
Dalinda Ait Aissa, Pierre Coquet, Jean Ruiz, Fabrice Ferre, Lucille Hoarau, Béatrice Riu-Poulenc, Benoit Bataille, Stein Silva
O38 ETCO2 improved outcome prediction of mechanical ventilation weaning
Jean-Luc Baudel, Simon Bourcier, Claire Pichereau, Naïke Bigé, Jalel Tahiri, Vincent Dubée, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
O39 Characteristics of 150 cases of weaning-induced pulmonary oedema and effects of diuretics
Liu Jinglun, Feng Shen, Jean-Louis Teboul, Christian Richard, Xavier Monnet
O40 Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis
Sébastien Bailly, Olivier Leroy, Philippe Montravers, Jean-Michel Constantin, Hervé Dupont, Didier Guillemot, Olivier Lortholary, Jean-Paul Mira, Pierre-François Perrigault, Jean-Pierre Gangneux, Elie Azoulay, Jean-François Timsit
O41 Intensive care acquired pneumonia due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) among patients with prior colonization: Frequency, risk factors and prognosis
Keyvan Razazi, Armand Mekontso-Dessap, Chloe Jansen, Nicolas de Prost, Christian Brun-Buisson
O42 Epidemiology, characteristics and outcomes of septic critically ill patients after the removal of a totally implantable venous-access ports
Marie Lecronier, Valade Sandrine, Naïke Bigé, Nicolas de Prost, Damien Roux, Jean-Damien Ricard, Eric Maury, Julien Mayaux, Elie Azoulay, Alexandre Demoule, Martin Dres
O43 Genetic risk of Pseudomonas aeruginosa ventilator-associated pneumonia: the EXTENSE study
Jean-Paul Mira, Sophie Blein, Nathalie Marin, Christophe Rousseau, Julien Charpentier, Jean-Daniel Chiche, Alexandre Pachot
O44 Cytomegalovirus reactivation enhances the virulence of a Staphylococcus aureus pneumonia in a mouse model
Sami Hraiech, Julien Bordes, Samuel Lehingue, Lamballerie Xavier De, Jean-Louis Mège, Jean-Marie Forel, Christophe Guervilly, Mélanie Adda, Didier Raoult, Laurent Papazian
O45 Families looking back: meaning-making after a decision to accept or refuse organ donation. A qualitative approach
Nancy Kentish-Barnes, Zoé Cohen-Solal, Elie Azoulay
O46 The letter of condolence at the heart of family centered care. A qualitative approach of relatives’ experience
Nancy Kentish-Barnes, Zoé Cohen-Solal, Virginie Souppart, Elie Azoulay
O47 Use of a children information booklet to support young relatives visiting a critically ill adult: impact on ICU practices
Lionel Kerhuel, Carole Haubertin, Isabelle Exbrayat, Elodie Rozières, Audrey Argain, Agnès Suc, Michel Vignes, Pierre Cougot, Béatrice Riu-Poulenc, Stein Silva, Olivier Fourcade, Elodie Brunel
O48 Withdrawal of life-support therapies reporting in ICU randomized controlled trial: Let us move to a transparent reporting—a systematic review
Jonathan Messika, Stéphane Gaudry, Florence Tubach, Emeline Dubief, Blandine Pasquet, Sylvie Guillo, Didier Dreyfuss, Jean-Damien Ricard
O49 Gasp during children end-of-life: healthcare providers’ feelings and knowledge
Charlotte Pierron, Marion Grimaud, Caroline Farnoux, Amélie Maillard
O50 Prognosis of malignant primary brain tumors in intensive care unit
Maxens Decavèle, Nicolas Weiss, Hélène Prodanovic, Julien Mayaux, Ahmed Idbaih, Agusti Alentorn, Jean-Yves Delattre, Thomas Similowski, Alexandre Demoule
O51 Impact of early immunomodulating treatment on outcome of adult patients with anti-N-methyl-d-aspartate receptor encephalitis requiring intensive care: a multicentre study with prospective long-term follow-up
Etienne De Montmollin, Sophie Demeret, Noelle Brule, Marie Conrad, Frédéric Dailler, Nicolas Lerolle, Jean-Christophe Navellou, Carole Schwebel, Mikael Alves, Martin Cour, Nicolas Engrand, Jean-Marie Tonnelier, Stephane Ruckly, Géraldine Picard, Véronique Rogemond, Jean-François Timsit, Jérôme Honnorat, Romain Sonneville, ENCEPHALITICA study group
O52 Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
Chiara Marzorati, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Dominique Benoit, Giuseppe Citerio, Elie Azoulay, Stéphane Legriel
O53 Ammonemia predicts severity and outcome in cirrhotic patients with hepatic encephalopathy in ICU
Simona Tripon, Maxime Mallet, Marika Rudler, Francoise Imbert-Bismut, Dominique Thabut, Nicolas Weiss
O54 Acute varicella zoster encephalitis admitted to the ICU: a case series of 47 patients
Emmanuel Canet, Adrien Mirouse, Romain Sonneville, Laurent Argaud, Stanislas Faguer, Keyvan Razazi, Claude Guérin, Pierre Perez, Anne-Sophie Moreau, Claire Pichereau, François Barbier, Sybille Merceron, Amélie Seguin, Julien Mayaux, Guillaume Geri, Christophe Guitton, Francois Labadie, Elie Azoulay
O55 High-flow nasal cannula for acute respiratory failure in immunocompromised patients
Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Etienne Faucher, Christophe Guitton, Antoine Rabbat, Christophe Girault, Achille Kouatchet, François Vincent, Fabrice Bruneel, Martine Nyunga, Amélie Seguin, Kada Klouche, Sylvie Chevret, Elie Azoulay, Groupe de Recherche en Reanimation Respiratoire du patient d’Onc-hématologie
O56 High-flow oxygen therapy through a nasal cannula in immunocompromised patients with acute hypoxemic respiratory failure
Jean-Pierre Frat, Stéphanie Ragot, Christophe Girault, Remi Coudroy, René Robert, Jean-Michel Constantin, Gwenael Prat, Thierry Boulain, Angéline Jamet,, Alain Mercat, Laurent Brochard, Arnaud, W. Thille
O57 Prospective validations of the PASTEIL score to assess the clinical pretest probability of Pneumocystis jirovecii pneumonia (PjP) in patients with hematologic malignancies (HMs) and acute respiratory failure (ARF)
Elie Azoulay, Sylvie Chevret, Antoine Roux, Etienne Faucher, François Vincent, Antoine Rabbat, Achille Kouatchet, Frédéric Pène, Julien Mayaux, Pierre Perez, Martine Nyunga, Christophe Guitton, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Virginie Lemiale
O58 Bedside contribution of electrical impedance tomography (EIT) to set mechanical ventilation for severe acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO)
Guillaume Franchineau, Nicolas Brechot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
O59 Liberal oxygenation versus restrictive oxygenation in ICU patients: effects on proinflammatory cytokines, sRAGE and organ dysfunctions - results of an ancillary study
Loïc Barrot, Gaël Piton, Michael Bailey, Rakshit Panwar, Nicolas Belin, François Belon,, Cyrille Patry, Jean-Christophe Navellou, Mathilde Grandperrin, Claire Chaignat, Guylaine Labro, Bérengère Vivet, Gilles Capellier
O60 Immature granulocyte level at the acute phase of sepsis, a potential prognostic marker of clinical deterioration. The Septiflux 2 multicenter trial
Thomas Daix, Estelle Guérin, Elsa Tavernier, Emmanuelle Mercier, Valérie Gissot, Christine Vallejo, Jean-Paul Mira, Christophe Guitton, Bruno François, Septiflux trial Group
O61 Analysis of microbiome and resistome using next-generation sequencing in urine samples from patients with sepsis, severe sepsis or septic shock
Céline Ravry, Bruno François, Emmanuelle Begot, Nicolas Pichon, Catherine Chapellas, Anne-Laure Fedou, Antoine Galy, Marie-Cécile Ploy, Olivier Barraud, Philippe Vignon
O62 Patients metabolomic profiles at intensive care admission
Aurelie Thooft, Raphael Conotte, Jean-Marie Colet, Patrick Biston, Michael Piagnerelli
O63 Lymphocyte phenotype during severe sepsis and septic shock
Matthieu Le Dorze, Virginie Tarazona,, Caren Brumpt,, Hélène Moins-Teisserenc,, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
O64 Myeloid-derived suppressor cells expressing arginase-1 and IDO play a major role in immune dysfunction during septic shock
Fabrice Uhel, Imane Azzaoui,, Murielle Gregoire, Céline Pangault, Joëlle Dulong,, Luc Cynober,, Jean-Marc Tadié, Mikaël Roussel,, Yves Le Tulzo, Karin Tarte
O65 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis admitted to the intensive care unit: a multicenter study
Julien Demiselle,, Johann Auchabie,, Julie Boisramé-Helms, Pierre François Dequin, Damien Du Cheyron, Michaël Darmon, Nicolas Chudeau, Guillaume Geri, René Robert, François Fourrier, Steven Grange, Christophe Guitton, Lise Piquilloud, Alexandre Lautrette, Sonia Boyer, Emmanuel Guérot, Julien Letheulle, Nicolas Lerolle
O66 Continuous renal replacement therapy versus intermittent hemodialysis: impact on mortality and renal recovery
Anne Sophie Truche, Michaël Darmon, Sébastien Bailly, Christophe Clec’h, Claire Dupuis, Benoit Misset, Elie Azoulay, Carole Schwebel, Lila Bouadma, Christophe Adrie, Guillaume Marcotte, Philippe Zaoui, Virginie Laurent, Dany Goldgran Toledano, Romain Sonneville, Bertrand Souweine, Jean-François Timsit
O67 Hospital survival and need of renal replacement therapy with respect to AKI duration in critically ill patients: results of a multicenter cohort study
Sophie Perinel Ragey, Anne Sophie Truche, Bertrand Souweine, Sébastien Bailly, Elie Azoulay, Lila Bouadma, Christophe Clec’h, Maïté Garrouste-Orgeas, Antoine Gros, Carole Schwebel, Christophe Adrie, Anne Sylvie Dumenil, Laurent Argaud, Samir Jamali, Dany Goldgran Toledano, Guillaume Marcotte, Michaël Darmon, Jean-François Timsit, For the OUTCOMEREA study group
O68 Early versus delayed initiation of renal replacement therapy in septic acute kidney injury: a retrospective study
Mikhael Chouraqui, Antoine Dewitte, Brigitte Chastel, Pauline Carles, Catherine Fleureau, Olivier Joannes-Boyau, Alexandre Ouattara
O69 Renal recovery after severe acute kidney injury in critically ill myeloma patients
Adrien Joseph, Marion Venot, Sandrine Valade, Eric Mariotte, Claire Pichereau, Akli Chermak, Virginie Lemiale, Elie Azoulay, Emmanuel Canet
O70 Impact of proactive nurse participation in ICU family conferences: a Mixed-Method Study
Maïté Garrouste-Orgeas, Adeline Max, Talia Lerin, Charles Grégoire, Stephane Ruckly, Martin Kloeckner, Cédric Bruel, Sandie Brochon, Francois Philippart, Emmanuelle Pichot, Clara Simons, Jean-François Timsit, Benoit Misset
O71 Duration of platelet storage and outcome of critically ill patients
Andrew Flint, Cécile Aubron, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe Mcquilten
O72 REA-C-SUR safety culture in intensive care in France: is there a link with morbi-mortality conferences?
Cédric Bretonnière, Daniel Villers, Christophe Guitton, Groupe RMM, Qualité et Sécurité des Soins - CBPR-CFAR
O73 Survival of critically ill solid cancer patients: results of a retrospective multicentre study
M Soares, Virginie Lemiale, Djamel Mokart, Frédéric Gonzalez, Fabrice Bruneel, Yves Cohen, Elie Azoulay, Michaël Darmon, François Vincent, for the GrrrOH: Groupe de recherche en réanimation respiratoire en Onco-Hématologie (Group for Research in Respiratory Intensive Care Onco-Hematology)
O74 Encouraging results of the French controlled donation after circulatory death Maastricht category III Program
Clémence Fauché, Michel Muller, Samuel Gay, Olivier Skowron, Albrice Levrat, Didier Dorez
O75 Clinical significance of cardiac troponin I release in severe trauma patients
Maxens Decavèle, Arnaud Foucrier, Sebastian Pease, Tobias Gauss, Catherine Paugam
O76 The modified Glasgow prognostic score is helpful in screening lung cancer patient at risk of hospitalization at the emergency department
Julie Gorham, Lieveke Ameye, Marianne Paesmans, Thierry Berghmans, Jean-Paul Sculier, Anne-Pascale Meert
O77 Relationship between body mass index classes and massive transfusion needs in trauma patients and predictive performance of the TASH score in obese and non-obese populations: a retrospective study on 910 trauma patients
Audrey De Jong, Pauline Deras, Orianne Martinez, Pascal Latry, Samir Jaber, Xavier Capdevila, Jonathan Charbit
O78 The Eschmann stylet as first tracheal access tool during emergency difficult tracheal intubation: An initial simulation trial followed by a clinical study
Jaubert J., Celia Etiennar, Lucie Ginoux, Jean-Luc Sebbah, Hakim Haouache, Gilles Dhonneur
O79 Maternal mortality risk factors for eclampsia
Chaigar Mohammed Cheikh, I. Moussaid, O. Ghazaoui, Kamal Belkadi, S. El Youssoufi, S. Salmi
O80 Use of aminoglycosides in cirrhotic patients admitted in intensive care for severe sepsis or septic shock: short- and intermediate-term impact on renal function and mortality
Laure Pajot, Benjamin Zuber, Carole Schwebel, Romain Sonneville, Benoit Misset, Michael Darmon, Guillaume Marcotte, Anne Sophie Truche, Dany Goldgran-Toledano, Bertrand Souweine, Samir Jamali, Stephane Ruckly, Elie Azoulay, Christophe Clec’h, Jean Pierre Bedos, Jean-François Timsit, OutcomeRéa
O81 Diagnostic yield and therapeutic impact of liver biopsy in the intensive care unit
Bertrand Sauneuf, Benoit Dupont, Axelle Eugène, Jean-Luc Hanouz, Françoise Galateau-Sallé, Nicolas Terzi
O82 Critically ill patients requiring liver transplantation: a 7-year monocentric retrospective experience
Baptiste Michard, Benjamin Lebas, Alexandra Boivin, Max Guillot, Jean-Etienne Herbrecht, Marie-Line Harlay, Ralf Janssen-Langenstein, Maleka Schenck, Bernard Ellero, Marie-Lorraine Woehl-Jaegle, Camille Besch, Vincent Castelain, Philippe Bachellier, Francis Schneider
O83 Hospital survival and access to liver transplantation of MARS-treated patients in France, 2004–2008: a retrospective multicenter study (RETROMARS)
Christophe Camus, Fawzi Saliba, Bernard Goubaux, Agnès Bonadona, Laurence Lavayssiere, Catherine Paugam, Alice Quinart, Olivier Barbot, Sebastien Dharancy, Bertrand Delafosse, Nicolas Pichon, Helene Barraud, Arnaud Galbois, Benoit Veber, Sophie Cayot, Bruno Souche, Clara Locher, RETROMARS Study Group
Olivier Roux, Francesco Figorilli, Antonella Putignano, Pauline Houssel, Claire Francoz, Emmanuel Weiss, Catherine Paugam, Banwari Agarwal, Rajiv Jalan, François Durand
P1 Severe brain injuries: epidemiology and outcome in a Tunisian medical intensive care unit
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P2 Stroke prognosis in the ICU of the regional hospital of Bizerte and withhold and withdrawal treatment decisions
Hatem Ghadhoune, E. Rachedi, J. Guissouma, A. Ben Slimene, W. Azzeza, H. Brahmi, H. Elghord
P3 Brain death predictive factors for traumatic brain injury
Ahmed Youssef Kada, Radia Chikh, Roza Slimani, Kheireddine.a Bouyoucef
P4 Guillain–Barré syndrome in intensive care unit: epidemiology and prognostic factors: analysis of 30 patients
Kais Regaieg, Chtara Kamilia, Najeh Baccouch, Olfa Turki, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir Bouaziz
P5 Eclampsia: epidemiological and clinical study about 194 cases
Fatma Kaaniche Medhioub, Najeh Baccouch, Manel Zekri, Kais Rgieg, Chokri Bhimada, Bouaziz Mounir
P6 Neuroimagery in eclampsia and preclampsia
Chaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, O. Ghazaoui, S. El Youssoufi, S. Salmi
P7 Interest of brain oxygen tension measurement (PbrO2) in the diagnosis of cerebral vasospasm after aneurismal subarachnoid hemorrhage
Elodie Lang, Stephane Welschbillig, Fabian Roy-Gash, Nicolas Engrand
P8 Noninvasive ventilation: an alternative to the intubation during myasthenic crisis
Mathilde Perrin, Fabian Roy-Gash, Stephane Welschbillig, Jean-Michel Devys
P9 Interest of the transcranial Doppler ultrasound in the management of severe traumatic brain injury
Soumia Benbernou, Houria Mokhtari-Djebli, Sofiane Ilies, Khalida Bouyacoub, Abdelkader Azza
P10 VV-ECMO on ARDS: toward a lower anticoagulation ratio?
Elie Zogheib, Joseph Nader, Léonie Villeret, Mathieu Guilbart, Patricia Besserve, Thierry Caus, Hervé Dupont
P11 Inter-hospital transportation of patients implanted with veno-venous ECMO: Experience of the Pitié-Salpêtrière mobile ECMO team
Nicolas Brechot, Ciro Mastroianni, Matthieu Schmidt, Francesca Santi, Guillaume Lebreton, Charles-Edouard Luyt, Jean Louis Trouillet, Ania Nieszkowska, Guillaume Hékimian, Leprince Pascal, Jean Chastre, Alain Combes
P12 Evolution of tidal volume and compliance under pressure-controlled mode during the first 24 hours of ECMO ARDS patients transported to a referral center
Hadrien Roze, Benjamin Repusseau, Jean-Christophe Richard, Virginie Perrier, Alexandre Ouattara
P13 Extracorporeal dioxide carbon removal (ECCO2R), a French national survey
Benjamin Deniau, Jean-Damien Ricard, Jonathan Messika, Didier Dreyfuss, Stéphane Gaudry
P14 Levels of microparticles in acute respiratory distress syndrome with veno-venous extra-corporeal membrane oxygenation
Christophe Guervilly, Fanny Klasen, Sami Hraiech, Jean-Marie Forel, Laurent Papazian
P15 In patients under extracorporeal CO2 removal therapy (ECCO2R) for ARDS can we do prone position? Efficiency, stability and safety of the maneuver
Jean Pierre Ponthus, Polysie Ngasseu, Virginie Amilien, Elise Barsam, Pierre Lehericey, Martial Tchir, Jean Francois Georger
P16 Feasibility of the implementation of a technique of extra-corporeal CO2 removal (ECCO2R) in an intensive care unit which does not use ECMO and its real utilization
Virginie Amilien, Jean Pierre Ponthus, Polysie Ngasseu, Martial Tchir, Elise Barsam, Pierre Lehericey, Jean Francois Georger
P17 Six-hour daily session of high-frequency oscillatory ventilation in moderate-to-severe ARDS: impact on the end-expiratory lung volume, compliance and oxygenation
Bérénice Puech, David Vandroux, Arnaud Roussiaux, Dominique Belcour, Cyril Ferdynus, Olivier Martinet, Julien Jabot
P18 Can we optimize prescription of laboratory tests in surgical intensive care unit (ICU)? Study of appropriateness of care
Marion Fresco, Gaëlle Demeilliers-Pfister, Véronique Merle, Valéry Brunel, Benoit Veber, Bertrand Dureuil
P19 Impact of the implementation of guidelines for laboratory testing in an intensive care unit
Sébastien Leydier, Isabelle Clerc-Urmes, Jérémie Lemarie, Charles-Henri Maigrat, Marie Conrad, Aurélie Cravoisy-Popovic, Damien Barraud, Lionel Nace, Sébastien Gibot, Nelly Agrinier, Pierre-Edouard Bollaert
P20 Identifying useless precaution to reduce costs in ICU
Vincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Guillaume Dumas, Elisabeth Falzone, Patrick Jault, Bernard Lenoir
P21 The ICU of the teaching hospital of Kinshasa
Joseph Nsiala Makunza, Nathalie Mejeni
P22 Security culture and risk management in intensive care units: risk cartography in a French intensive care unit
Amélie Mazaud, Sébastien Béague, Anne-Flore Rousselle, Alain Durocher
P23 Acquiring messages of medical articles according to the reading style: the BIBLIOFLASH multicenter study
Romain Sonneville, Benjamin Sztrymf, Emmanuel Canet, for the BIBLIOFLASH study group
P24 ICU portrayal in social media channels
Pauline Perez, Alexandra Grinea, Nicolas Weiss
P25 The burnout syndrome in a Tunisian intensive care unit: what is the truth?
Hassen Ben Ghezala, Naoures Bedoui, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P26 Resistance of endotracheal tubes measured after extubation in ICU patients
Alina Stoian, Loredana Baboi, Florent Gobert, Hodane Yonis, Romain Tapponier, Jean-Christophe Richard, Claude Guérin
P27 Length of endotracheal tube, humidification system and airway resistance: an experimental bench study
Frédéric Duprez, Arnaud Bruyneel, Thierry Bonus, Grégory Cuvelier, Sharam Machayeckhi, Sandra Olieuz, Alexandre Legrand
P28 Diagnosis contribution and safety of bronchoalveolar lavage in intensive care unit
Fatma Feki, Amira Jamoussi, Takoua Merhebene, Emna Braham, Asma Ghariani, Faouzi El Mezni, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P29 Impact of fiberoptic bronchoscopy performed under noninvasive ventilation on the outcome of critically ill patients: a cohort study over 11 years
Antoine Marchalot, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Steven Grange, Emmanuel Besnier, Gioia Gastaldi, Julien Abily, Marion Beuzelin, Fabienne Tamion
P30 New single-use flexible bronchoscope dedicated for the invasive mechanical ventilation: a proof of concept
Mai-Anh Nay, Adrien Auvet, Julie Mankikian, Virginie Hervé, Antoine Guillon
P31 Incidence of and risk factors for difficult intubation in ICU
Marie Soulie, Pierrick Cronier, Elie Kantor, Laura Federici, Marion Gilbert, Ilham Mezhari, Gérald Choukroun, Sophie Marque
P32 Endotracheal self-extubation in the intensive care unit: a two-year observational study
Z. Coppere, Maxens Decavèle, Jean-Pierre Fulgencio, Clarisse Blayau, Tai Pham, Muriel Fartoukh, Michel Djibre
P33 Criteria to assess extubation readiness and prediction of successful weaning
Matthieu Reffienna, Michel Arnaout, Sébastien Lefort, Anne-Sophie Debue, Fabrice Daviaud, Sarah Cabon, Frédéric Pène, Julien Charpentier, Alain Cariou, Jean-Paul Mira, Jean-Daniel Chiche, Working Group on Mechanical Ventilation
P34 Domestic accidents during school holidays in children
Nabil Tabet Aoul, Zakaria Addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
P35 Pediatric ARDS: interest of prone positioning and NAVA ventilation during veno-venous ECMO
Sylvie Soulier, Philippe Mauriat, Nadir Tafer, Alexandre Ouattara
P36 Esogastric pressure measurement as a guide for noninvasive ventilation in unexplained hypercapnic respiratory failure in infants
Guillaume Mortamet, Alessandro Amaddeo, Sonia Khirani, Brigitte Fauroux
P37 Experience Of Antibacterial Treatment Of Bone And Joint Sepsis Of Young Children
Gennadiy Khanes, Olga Liutko, Svitlana Bidnenko
P38 Comparison of toxic and septic shocks in children
Solenn Remy, Emilie Doye, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne Javouhey
P39 Pediatric carbon monoxide poisoning in the Ile-de-France Region, Link between HbCO level and clinical presentation
Imane El Aouane, Aben Essid, Wallid Hammami, Isabelle Haegy, Jacques Bataille, Jean Bergounioux
P40 Refractory septic shock in children: an ESPNIC definition
Luc Morin, Samiran Ray, Graeme Maclaren, Etienne Javouhey, Simon Nadel, Martin Kneyber, Mark Peters, Koos Jansen, Daniele De Luca, Clare Wilson, Luregn Schlapbach, Pierre Tissières, The infection, inflammation and sepsis section of the ESPNIC
P41 Impact of the Leonetti law on end-of-life practices in a French NICU and PICU, from January 2011 to December 2014
Anne-Claire Girard, Elodie Savajols, Antoine Burguet, Denis Semama, Stephanie Litzler-Renault
P42 Mortality risk factors for anticoagulant-related bleeding
Ines Sedghiani, Hana Fredj, Malek Hassouna, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P43 Management of the polytrauma in the emergency department of CHUOran
Houria Mokhtari-Djebli, Soumia Benbernou, Ahmed Dernane, Fouad Bouakkaz, Khalida Bouyacoub, Abdelkader Azza
P44 Realization of a feedback system of respiratory parameters during CPR
Lhoucine Ben Taleb, Elmaati Essoukaki, A Zeddine Mouhsen, Aissam Lyazidi, Jean-Christophe Marie Richard, Ahmed Mouhsen, Mohammed Harmouchi, Mourad Rattal
P45 Burns from French military operations: a 14-year retrospective observational analysis
Matthias Huck, Thomas Leclerc, Nicolas Donat, Audrey Cirodde, Jean-Vivien Schaal, Yannick Masson, Clément Hoffmann
P46 Drowning in Martinique—characteristics and infectious complications
Dabor Resiere, Laura Cerland, Ruddy Valentino, C Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y Brouste, Bruno Megarbane, Hossein Mehdaoui
P47 Prevalence, characteristics, and associated factors to physician’s conflicts in Emergency Department: A multicentric Moroccan study
Jihane Belayachi, Maha Louriz, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane Abouqal
P48 Serious peripartum complications needing admission in obstetrical ICU: retrospective study about 127 cases
Affra Brahim, Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Khalil Tarmiz, Khaled Benjazia
P49 Epidemiology of suicide in emergency department
Neila Maaroufi, Abid Zeineb, Dhaouadi Mahassen
P50 Beneficial cardiovascular effects of O-GlcNAc stimulation in early phase of septic shock
Julien Cadiet, Marine Ferron, Valentine Prat, Angelique Erraud, Virginie Aillerie, Mathieu Mevel, Amandine Grabherr, John C. Chatham, Chantal Gauthier, Benjamin Lauzier, Bertrand Rozec
P51 MiR-21 deficiency increases mortality during experimental septic shock
Jeremie Joffre, Xavier Loyer, Jean-Rémi Lavillegrand, Lynda Zeboudj, Ludivine Laurans, Bruno Esposito, Alain Tedgui, Ziad Mallat, Hafid Ait-Oufella
P52 Isolated heart rate reduction by ivabradine does not improve cardiac and vascular function in experimental septic shock
Chaojie Wei, Narimane Al Kattani, Huguette Louis, Sophie Orlowski, Bruno Levy, Antoine Kimmoun
P53 Exploration and modulation of the EGF-R during experimental septic shock
Jean-Rémi Lavillegrand, Lynda Zeboudj, Jeremie Joffre,, Ludivine Laurans,, Bruno Esposito, Alain Tedgui, Pierre-Louis Tharaux, Hafid Ait-Oufella
P54 An intravenous omega-3 bolus at reperfusion time improves shock and vascular dysfunction in a myocardial ischemia–reperfusion rat model
Mélanie Burban, Grégory Meyer, Anne Olland, Blandine Yver, Florence Toti, Valérie Schini-Kerth, Alexandra Monnier, Alexandra Boivin, Pierrick Leborgne, Ferhat Meziani, Julie Boisramé-Helms
P55 Impact of urantide antagonist of urotensinergic system on myocardial function during a murine model of septic shock
Emmanuel Besnier, Thomas Clavier, Mulder Paulus, Hélène Castel, Vincent Richard, Fabienne Tamion
P56 Association of dexamethasone and antibodies to poly-β(1,6)-n-acetyl-glucosamine in prevention and treatment of neonatal bacterial meningitis: an experimental study
Stéphanie Pons, Bruno Mourvillier, David Skurnik
P57 Hyperoxemia as a risk factor for ventilator-associated pneumonia
Sophie Six, Karim Jaffal, Saad Nseir
P59 Significance of prior digestive colonisation with extended-spectrum beta-lactamase producing Enterobacteriaceae in patients with ventilator-associated pneumonia
Rémi Bruyère, Clara Vigneron, Audrey Large, Julien Bador, Serge Aho, Sebastien Prin, Jean-Pierre Quenot, Pierre-Emmanuel Charles
P60 Lower respiratory tract colonization in mechanically ventilated patients: Incidence, risk factors and impact on prognosis
Yosr Touil, Soufia Ayed, Habiba Sik Ali, Najla Tilouch, Houda Mateur, I Talik, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous
P61 Epidemiology of ventilator-associated pneumonia in the ICU among patients already hospitalized: early- versus late-onset pneumonia
Mathilde Grandperrin, Isabelle Patry, Xavier Bertrand, Jean-Christophe Navellou, Gaël Piton, Gilles Capellier
P62 Systematic review of inclusion/exclusion criteria, judgment criteria and statistical hypothesis in randomized controlled trials assessing the efficacy of antimicrobials for hospital-acquired and ventilator-associated pneumonia treatment
Emmanuel Weiss, Jean-Ralph Zahar, Christophe Adrie, Wafa Essaied, Martin Wolkewitz, Jean-François Timsit
P63 Gram stain identification resulting from blindly inserted telescoping plugged catheter material. Does it contribute to diagnosis and treatment of ventilator-associated pneumonia?
Mickaël Soued, Fabrice Cook, David Lobo, Roman Mounier, Aurélie Emirian, Jean Winoc Decousser, Gilles Dhonneur
P64 Colistin in nosocomial pneumonia in intensive care
Hanane Ezzouine, Mohamed Toufik Slaoui, Abdellatif Benslama
P65 Bedside tissue perfusion evaluation predicts intradialytic hemodynamic instability in critically ill patients
Naïke Bigé, Claire Pichereau, Jean-Rémi Lavillegrand, Arnaud Galbois, Mikael Alves, Jean-Luc Baudel, Simon Bourcier, Vincent Dubée, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P66 Evaluation of electrolytes and acid–base disorders in patients undergoing citrate-based anticoagulation for continuous renal replacement therapy in intensive care unit
Benjamin Delmas, Olivier Joannes-Boyau, Antoine Dewitte, Julien Jabot, Dorothée Valance, Nicolas Allou, Jérôme Allyn, Catherine Fleureau,, Alexandre Ouattara
P67 Continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a cost study impact of replacement fluids consumptions
Elodie Jean-Bart, Floriane Bel., Fabienne Morey, Rémi Bruyère, Nicholas Sedillot
P68 Acute kidney injury in patients receiving liposomal amphotericin B in an intensive care unit: register of 104 patients from 2008 to 2014
Marion Venot, Lucie Biard, Sylvie Chevret, Sandrine Valade, Eric Mariotte, Claire Pichereau, Virginie Lemiale, Elie Azoulay, Emmanuel Canet
P69 Regional citrate-based anticoagulation for dummies in continuous venovenous hemofiltration: does it work?
Dorothée Valance, Richard Galliot, Romain Zunarelli, David Vandroux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, Julien Jabot
P70 Incidence of and risk factors for acute kidney injury in early postoperative liver transplantation according to AKIN classification
Jean-Charles Cartier, Thomas Jouve, Marie-Noëlle Hilleret, Rebecca Hamidfar-Roy, Claire Ara-Somohano, Clémence Minet, Agnès Bonadona, Carole Schwebel
P71 Metabolic acidosis uncompensated by kidney in septic patients: a predictive factor for acute kidney injury?
Aline Pourcelet, Jean-Michel Hougardy, Pierre Defrance, Patrick Biston, Michael Piagnerelli
P72 Blood volume monitoring is useful to predict intradialytic hypotension during intermittent hemodialysis
Louis De Laforcade, Alexandre Boyer, Didier Gruson, Benjamin Clouzeau
P73 Risk factors for occurrence of acute kidney injury in diabetic ketoacidosis
Najah Hajjam, Ines Sedghiani, Houda Nasri, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P74 Face-to-face tracheal intubation with the video laryngoscope Airtraq in the sitting patients: a report of 3-year experience in patients after failed conventional tracheal intubation technique
Gilles Dhonneur, Nicolas Mongardon, Eric Levesque, Hakim Haouache
P75 Ultrasound-guided central venous access technique among French intensivists
Marie-Anaïs Bastide, Jack Richecoeur, Eric Frenoy, Christian Lemaire, Bertrand Sauneuf, Fabienne Tamion, Saad Nseir, Damien Du Cheyron, Hervé Dupont, Julien Maizel, BoReal Study Group
P76 Ultrasound-guided venous catheter insertion. What do French intensivists really do?
Hafid Ait-Oufella, Eric Maury, Julien Maizel, Frédérique Schortgen, Cécile Aubron, Christophe Clec’h, Christophe Guitton, Kada Klouche, Nicolas Lerolle, Frédéric Pène, Sebastien Preau, Carole Schwebel, Nicolas Terzi, Frédéric Vargas, Vincent Castelain
P77 Can we trust new connected devices recording heart rate and oxygen saturation? A concordance assessment in intensive care unit
Franck Ehooman, Yacine Tandjaoui-Lambiotte, Claire Montlahuc, Guillaume Van Der Meersch, Johanna Oziel, Jean Bardon, Matthieu Resche-Rigon, Nicolas Postel-Vinay, Yves Cohen
P78 Hemoglobin monitoring with HemoCue©, spectrophotometry and blood cells analyzer: comparison of agreement, completion time and costs
Mehdi Lafi, Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin Sztrymf
P79 Activated partial thromboplastin time and anti-Xa measurements in heparin monitoring among critical care patients
Noémie Tencé, Inès Zaien, Martine Wolf, Pierre Trouiller, Frédéric Jacobs
P80 Agreement between the Point-Of-Care Siemens RAPIDPoint® 500 Blood gas system and central laboratory measurement of hemoglobin, hematocrit, glucose and electrolytes in ICU patients
Jérôme Allardet-Servent, Melissa Lebsir, Christian Dubroca, Mireille Portugal, Matthias Castanier, Thomas Signouret, Guillemette Thomas, Rettinavelou Soundaravelou, Anne Lepidi, Philippe Halfon, Jean-Marie Seghboyan
P81 Clinical features and prognosis of pesticide poisoning
Neila Maaroufi, Dhaouadi Mahassen, Abid Zeineb
P82 Variability of neurobehavioral toxicity of naphyrone, a new synthetic cathinone, according to its acute or binge administration
Camille Gamblin, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno Megarbane
P83 Acute acenocoumarin poisoning: an epidemiological and clinical study
A. M’rad, Hana Fredj, Messaouda Khelfa, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P84 Death by deliberate self-poisoning in Sfax, Tunisia: Victims characteristics and toxic substance profile
Youssef Nouma, Wiem Ben Amar, Sami Bardaa, Karama Regaieg, Kaouthar Jammeli, Mabrouk Bahloul, Zouheir Hammami, Maatoug Samir
P85 Adverse drug reactions (ADRs) collected by medical-staffed ambulances: pilot study
A. Lillo-Le Louët, F. Baud, C. Le Beller, B. Vivien, L. Soufir, P. Carli and H. Le Louët
P86 Prognostic value of plasma concentration of acebutolol in acute poisoning
A. M’rad, Youssef Blel, Fatma Essafi, Nasreddine Foudhaili, Abdelaziz Ben Slimen, Nozha Brahmi, M. Amamou
P87 Baseline pharmacologic treatment for patients admitted in ICU for AECOPD: trends in use and conformity to the GOLD guidelines
Islem Ouanes, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Nesrine Boujelbene, Fahmi Dachraoui, Asma Hachani, Saousen Ben Abdallah, Hend Ben Lakhal, Chaima Ghribi, Imen Ben Ali, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri Abroug
P88 Blood eosinophils levels and acute exacerbations of COPD
Islem Ouanes, Asma Hachani, Lamia Ouanes-Besbes, Saousen Ben Abdallah, Rami Jabla, Hedia Hammed, Mahdi Marzouk, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Chaima Ghribi, Fahmi Dachraoui, Fekri Abroug
P89 POFE: postoperative outcomes of chronic obstructive pulmonary disease (COPD) frequent exacerbators after pulmonary resection—a pilot study
Suela Demiri, Christine Lorut, Van Lang, Daniel Luu, Antoine Rabbat, Aurélie Lefebvre, Marco Alifano, Jean-Francois Reignard, Marc Samama, Daniel Dusser, Nicolas Roche
P90 Optimal delivery of salbutamol with a pressurized metered-dose inhaler within a high-flow nasal therapy circuit
François Réminiac, Cassandre Landel, Samuel Gensburger, Thomas Bocar, Lydiane Mordier, Marion Philippe, Déborah Le Pennec, Laurent Vecellio, Stephan Ehrmann
P91 Differences in perceptions between the various healthcare professionals working at the bedside of the risks related to the rehabilitation procedures
Laurent Poiroux, David Thevoz, Julien Simons, Cheryl Hickmann, Jean Roeseler, Anthéa Loiez, Stéphanie Gérard, Nicolas Dousse, Tai Pham, Nicolas Terzi, Lise Piquilloud
P92 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practice
Lorraine Ducroux, Sylvie L’hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent Castelain
P93 Extracorporeal membrane oxygenation for pheochromocytoma-induced cardiogenic shock: report of nine cases
Guillaume Hékimian, Nicolas Brechot, Matthieu Schmidt, Fatima Kharcha, Cécile Ghander, Guillaume Lebreton, Christophe Tresallet, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Charles-Edouard Luyt
P94 Mortality related to cardiogenic shock in critically ill patients in France, 1997–2012
Etienne Puymirat, Jean-Yves Fagon, Philippe Aegerter, Florence Boissier, Jean-Luc Diehl, Caroline Hauw-Berlemont, Bertrand Guidet, Gilles Chatellier, Nicolas Danchin, Nadia Aissaoui
P95 Benefits of extracorporeal life support (ECLS) in elderly patients with postcardiotomy refractory cardiogenic shock
Nadia Aissat, R. Bernard, Guillaume Lebreton, Dimitri Margetis, Julien Amour, Pascal Leprince, Adrien Bouglé
P96 Heart transplantation versus ventricular assist device: which therapy for patients with refractory cardiogenic shock?
Charles Vidal, Guillaume Lebreton, Djavidi Nima, Varnous Shaida, Adrien Bouglé, Pascal Leprince, Julien Amour
P97 Refractory cardiogenic shock in immunocompromised patients rescued by veno-arterial extracorporeal membrane oxygenation
Amandine Dorget, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
P98 Which index severity to use in obstetric medium? (Comparison of 4 scores)
Rabi Toufiki, Youssef Mouaffak, Ahmed Rhassan El Adib, M. Amine
P99 Maternal mortality in obstetric department of UH IBN ROCHD, Casablanca, Morocco
Kamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. Moumine, S. El Youssoufi, S. Salmi
P100 Disseminated intravascular coagulation in pregnant women: evaluation of a new score
Marie Jonard, Anne Sophie Ducloy-Bouthors, François Fourrier
P101 Validity of severity scores in critically ill obstetric patients
Fatma Kaaniche Medhioub, Anis Chaari, Olfa Turki, Kais Rgieg, Mabrouk Bahloul, Hmida Chokri Ben, Bouaziz Mounir
P102 Evaluation of a neuromuscular blockade with benzylisoquinoliniums: a comparison of a train of four with a clinical assessment
Pierre Bouju, Nicolas Barbarot, Arnaud Gacouin, Fabrice Uhel, Julien Letheulle, Pierre Fillatre, Guillaume Grillet, Angélique Goepp, Jean-Marc Tadié, Yves Le Tulzo
P103 The use of enteral route for drug administration in the ICU is dimly rational
Anne-Laure Clairet, Gilles Capellier, Samuel Limat, Christian Cornette, Gaël Piton
P104 Microcirculatory effects of norepinephrine in septic shock: a muscle microdialysis study
Amira Fatnassi, Zied Hajjej, Chiheb Romdhani, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P105 Administration of drugs per os by stomach tube for enteral feeding in surgical ICU
Hind Taibi, Ijlal Elatiqi, A Iraqui, Rachid Cherkab, Wafae Haddad, Chafik Elkettani, Lahoucine Barrou
P106 Implementation of an intensive care follow-up clinic
Fabien Cave, Alain Mercat, Nicolas Lerolle
P107 Needs assessment of adults post-intensive care rehabilitation department in Amiens University Hospital
Gaelle Bacari-Risal, Pierre Louis Doutrellot, Benoit Vaysse, M. Inan, K. Khelfoun, M. Nasserallah, Julien Maizel, C. Legrand-Monteil, S. Tasseel-Ponche
P108 Factors of degradation on independence and quality of life at 3 and 6 months after stay in intensive care unit
Benjamin Kowalski, Anne Guaguere, Claire Boulle-Geronimi
P109 Octavie: Epidemiological study of mortality and autonomy 3 and 6 months after ICU stay for very elderly patients
Juliette Masse, Clément Vanbaelinghem, Patrick Herbecq
P110 Analysis of burn injuries in the elderly
Amel Mokline, Syrine Draief, Lazhari Gharsallah, Imen Rahmani, Bahija Gasri, Sofiene Tlaili, Rym Hammouda, Amen Allah Messadi
P111 ICU admission criteria for patients 85 years and older
Philippe Michel, Bruno Gelée, Fouad Fadel, Marie Thuong
P112 Facteurs pronostiques chez les patients âgés admis en réanimation médicale. Prognostic factors in elderly patients admitted in medical intensive care
Sandra Ait-Aoudia, Salima Laddi, Mohamed-Mohcen Sahraoui
P113 Uncontrolled donation after circulatory determination of death: 42 months of experience in a general hospital
Clémence Fauché, Samuel Gay, Michel Muller, Anna Faucher, Olivier Skowron, Albrice Levrat, Didier Dorez
P114 Epidemiology of long stays in ICU
Bertrand Hermann, Caroline Hauw Berlemont, Alexandra Monnier, Florence Boissier, Nadia Aissaoui, Jean-Yves Fagon, Jean-Luc Diehl, Emmanuel Guérot
P115 Are daily sedation stops safe in a medical ICU?
Michel Arnaout, Julien Charpentier, Benoit Champigneulle, Julie Busson, Anne-Sophie Debue, Julie Dhumeaux, Guillaume Geri, Wulfran Bougouin, Nicole Ericher, Sébastien Lefort, Pierre Lucas, Alain Cariou, Jean-Paul Mira, Frédéric Pène, Jean-Daniel Chiche, Groupe de travail sur la ventilation
P116 Delay in awakening after stopping continuous sedation in critically ill patients: incidence, risk factors and impact on ventilator weaning
Magalie Dumas, Celine Chapelle, Benedicte Philippon-Jouve, Jerome Morel, Pascal Beuret
P117 Risk factors and prognosis impact of decreased patient–ventilator synchrony in mechanically ventilated patients—a prospective study
Côme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6—Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, Paris
P118 High-flow oxygen therapy through a nasal cannula versus noninvasive ventilation versus in immunocompromised patients with acute respiratory failure
Remi Coudroy, Angéline Jamet, Philippe Petua, René Robert, Jean-Pierre Frat, Arnaud, W. Thille
P119 The use of dexmedetomidine in patients with noninvasive ventilation: a preliminary study
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
P120 Comparison of tolerance of 4 interfaces for preventive noninvasive ventilation after abdominal surgery in intensive care units assessed by patients and caregivers
Audrey De Jong, Albert Prades, Marion Monnin, Martin Mahul, Marion Basty, Clément Monet, Benjamin Mounet, Emmanuel Futier, Gérald Chanques, Samir Jaber
P121 Dexmedetomidine, new approach in sedation analgesia: a prospective and observational study of mechanically ventilated patients in adults intensive care units in a university hospital during the first year of use
Audrey Leroux, Xavier Oudinot, Gaëlle Demeilliers-Pfister, Marc Laurent
P122 Pain, confusion, and agitation associated with noninvasive ventilation
Nesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Saousen Ben Abdallah, Mahdi Marzouk, Asma Hachani, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Chaima Ghribi, Imen Abdellaoui, Lamia Ouanes-Besbes, Fekri Abroug
P123 Impact of metformin on prognosis of ICU patients
Sebastien Jochmans, Jean-Emmanuel Alphonsine, Ly Van Vong, Nathalie Rolin, Oumar Sy, Jean Serbource-Goguel, Jonathan Chelly, Olivier Ellrodt, Mehran Monchi, Christophe Vinsonneau
P124 Serum cholinesterase activity in the diagnosis of septic shock due to bacterial infections: a new specific biomarker of sepsis
Mabrouk Bahloul, Turki Olfa, Najeh Baccouche, Kais Regaieg, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir Bouaziz
P125 Is hyperoxaemia a rare event during septic shock patients management?
Amélie Trichot, Gwenhaël Colin, Jean-Baptiste Lascarrou, Isabelle Vinatier, Konstantinos Bachoumas, Jean-Claude Lacherade, Maud Fiancette, Aurélie Joret, Aihem Yehia, Christine Lebert, Matthieu Henry-Laguarrigue, Laurent Martin-Lefèvre
P126 Myocardial depressant factor during human septic shock: screening of twenty-three cytokines and chemokines
Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Nicolas de Prost, Aurelien Seemann, Christian Brun-Buisson, Sophie Hüe, Armand Mekontso-Dessap
P127 Plasma of septic shock patients modifies in vitro mitochondrial respiration of human PBMC as well as lymphocytes and monocytes cell lines
Raphaël Clere-Jehl, Julie Boisramé-Helms, Anne-Laure Charles, Pierrick Leborgne, Xavier Delabranche, Bernard Geny, Ferhat Meziani, Pascal Bilbault
P128 Assessment of skin endothelial functions during severe infections
Simon Bourcier, Claire Pichereau, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jalel Tahiri, Naïke Bigé, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P129 Toe-to-Room temperature gradient correlates with tissue perfusion and predicts outcome during septic shock
Simon Bourcier, Claire Pichereau, Pierre Yves Boêlle, Nemlaghi Safaa, Vincent Dubée, Gabriel Lejour, Jean-Luc Baudel, Arnaud Galbois, Jean-Rémi Lavillegrand, Naïke Bigé, Jalel Tahiri, Eric Maury, Bertrand Guidet, Hafid Ait-Oufella
P130 Determination of HLA-DR expression on monocytes in heart recipients and clinical outcome correlation
Sylvie Paulus, Claire Flamens, Guillaume Monneret, Julie Demaret, Jean Neidecker
P131 Nosocomial infections in neonates under ECMO
Jerome Rambaud, Cecile Allioux, Romain Guedj, Isabelle Guellec, Julia Guilbert, Pierre-Louis Leger, Maryne Demoulin, Amélie Durandy, Sandrine Jean, Ricardo Carbajal
P132 Point-of-care ultrasound in pediatric and neonatal intensive care units: prospective, observational transversal study
Aurélie Morand, Laurent Zieleskiewicz, Olivier Brissaud, Stéphane Le Bel, Mickael Afanetti, Zoé Meresse, Astrid Botte, Michel Panuel, Laurent Thomachot, Jean-Michel Constantin, Marc Leone, Fabrice Michel
P133 Use of continuous infusion of clonidine for sedation in critically ill children: indications, efficacy and side effects
Anna Deho’, Laïly Sadozai, Stéphane Dauger, Sonia Prot-Labarthe
P134 Pharmacokinetic analysis of continuous infusion vancomycin therapy in critically ill children
Mathieu Genuini, Mehdi Oualha, Moulin Florence, Jean-Marc Treluyer, Fabrice Lesage, Sylvain Renolleau
P135 Incidence of central venous catheter-associated bacteraemia in a paediatric intensive care unit
Emmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane LeteurtreEmmanuelle Chalavon, Claire Le Reun, Rodrigue Dessein, Bruno Grandbastien, Alain Duhamel, Sarah Pesin, François Dubos, Stéphane Leteurtre
P136 Outcome at 2 months at the infectious level of the pediatric central venous catheters: prospective evaluation of the guidelines optimization impact
Marie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe DesprezMarie-Aude Puel, Marie Szulc, Anais Philippe, François Severac, Dominique Astruc, Pierre Kuhn, Philippe Desprez
P137 Ten years of intensive care in children hospital in Oran, Algeria
Nabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil AouffenNabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
P138 High-frequency percussive ventilation during neonatal transportation: a pilot study
Benoît Colomb, Karine Kolev-Descamp, Anne Marie Petion, Laurent Queudet, Elodie Savajols, Stephanie Litzler-Renault, Denis Semama
P139 Lymphopenia after severe infectious shock in children: association with severity and risk for nosocomial infection
Emilie Doye, Solenn Remy, Nicolas Voirin, Delphine Maucort-Boulch, Karine Kolev-Descamp, Guillaume Monneret, Etienne Javouhey
P140 Importance of troponin evaluation in scorpion envenomation in pediatric intensive care unit
Mouaffak Youssef
P141 Hyperosmolar therapy in pediatric traumatic brain injury: a retrospective study
Nadia Roumeliotis, Christian Dong, Geraldine Pettersen, Louis Crevier, Guillaume Emeriaud
P142 Cerebral sinovenous thrombosis in children: report of seven cases
Mouaffak Youssef
P143 Optimising nurse confidence and skill acquisition in paediatric continuous renal replacement therapy (pCRRT) through a training programme: result of the first-year experience in a tertiary care centre
Jérôme Naudin, Laetitia Abdallah, Marion Ganier, Karine Frannais, Dylia Douglas, Cecile Flusin, Anna Deho’, Stéphane Dauger
P144 From high-quality electronic database to the new concept of perpetual patient. Preliminary results
David Brossier, Redha Eltaani, Michaël Sauthier, Guillaume Emeriaud, Bernard Guillois, Philippe Jouvet
P145 Transportation of children on extracorporeal membrane oxygenation: 1-year experience of a tertiary referral center in the Paris regionJerome Rambaud, Pierre-Louis Leger, Michelle Larroquet, Alain Amblard, Noella Lode, Julia Guilbert, Sandrine Jean, Isabelle Guellec, Isabelle Casadevall, Katia Kessous, Hervé Walti, Ricardo Carbajal
P146 Acute neurotoxicity of bath salts combining 3,4-methylenedioxypyrovalerone and mephedrone in the rat
Christophe Poiré, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Huixiong Chen, Bruno Megarbane
P147 Acute organophosphate poisoning: what about pralidoxime use?
A. M’rad, Sahar Habacha, Bassem Chatbri, Youssef Blel, H Thabet, Nozha Brahmi, M. Amamou
P148 Acute nifedipine poisoning: clinical and prognosis aspects
A. M’rad, Fatma Essafi, Nasreddine Foudhaili, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P149 Acute behavioral toxicity and addictive liability of the new synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in the rat
Cyril Masniere, Nadia Benturquia, Olivier Roussel, Lucie Chevillard, Patricia Risede, Jacques Callebert, Bruno Megarbane
P150 Clinical and therapeutic characteristics of metformin poisoningA. M’rad, Messaouda Khelfa, Hana Fredj, Youssef Blel, H. Thabet, Nozha Brahmi, M. Amamou
P151 Calcium channel blockers poisoning
Samar Souissi, Hatem El Ghord, N. Kouraichi, N. Brahmi, H. Thabet, M. Amamou
P152 Characteristics and outcomes in patients with community-acquired pneumonia admitted to intensive care unit
Takoua Marhbène, Islam Mejri, Amira Jamoussi, Douha Lakhdar, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P153 Comparison of characteristics and outcomes of pneumococcal community-acquired pneumonia versus other pathogens
Takoua T. Merhabane, Héla Maamouri, Amira Jamoussi, Asma Ghariani, Leila Slim, Jalila Ben Khelil, Mohamed Besbes
P154 Outcome of L. pneumophila pneumonia and risk factors for ICU admission
Oestreicher Charlotte, Helena Wegelius, Caroline Landelle, Jacques Schrenzel, Laurent Kaiser, Jérôme Pugin
P155 The descending necrotizing mediastinitis: report of 60 cases
Hind Belhadj
P156 Characteristics, mortality risk factors and therapeutic approach of ARDS in patients with severe leptospirosis in Reunion Island
Paul Chanareille, Julien Jabot, Benjamin Delmas, Arnaud Roussiaux, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David Vandroux
P157 Characterization of organ dysfunction in severe leptospirosis
Adélie Ladureau, Alice Sanna, Amélie Rolle, Bertrand Pons, Pascale Piednoir, Fanny Ardisson, Frédéric Martino, Thomas Bernos, Khalid Elkoun, Elie Elain, Roland Lawson, Matthieu Resh-Rigon, Sophie Belorgey, Guillaume Thiery
P158 Report of experience: management of a pre-XDR and XDR-TB population hospitalized in a medical ICU
Caroline Hauw Berlemont, Cyprian Pricopi, Florence Boissier, Alexandra Monnier, Françoise Barthes, Jean-Luc Diehl, Jean-Yves Fagon, Emmanuel Guérot
P159 Benefit of magnesium sulfate for tetanus management in adults: case of the provincial general referral hospital of Kinshasa
Thansya Doddie, Mj Nsiala, Nh Situakibanza, Be Amisi, Mj Kazadi, Ma Kilembe
P160 Ebola fever outbreak: questioning the delivery of care
Christophe Clement, François Lamontagne
P161 Marked decrease in the incidence of ventilator-associated pneumonia using a bundle of care containing selective oropharyngeal decontamination
Boyer, Valérie Nocquet, Caroline Landelle, Sébastien Naimo, Ronan Raulais, Emilie Genevois, Lucie Bouchoud, Filippo Boroli, Nour Abidi, Mohamed Abbas, Stefan Harbarth, Jérôme Pugin
P162 Ventilator-associated pneumonia prevention by oral care improvement: a before–after study
Pierre-Emmanuel Charles, Caroline Dereux, Audrey Large, Rémi Bruyère, Sebastien Prin, Julien Bador, Jean-Pierre Quenot
P163 Impact of a multifaceted bundle ventilator-associated pneumonia prevention program in a secondary care medical–surgical intensive care unit
Stanislas De Guillebon, Eloise Morisse, Julie France, Deborah Gasser, Philippe Badia, Walter Picard
P164 Daily chlorhexidine bathing in a medical intensive care unit: effects on healthcare-associated infections and on acquisition of multidrug-resistant bacteria
P. Corne, Nicolas Molinari, I. De Boulastel, S. Seguin, A. Blasco, V. Ledur, Olivier Jonquet, Kada Klouche
P165 Impact of twin bedrooms intensive care unit on the epidemiology of extended-spectrum beta-lactamase-producing enterobacteriaceae
Paktoris-Papine Sophie, Margaux Artiguenave, Faten El Sayed, Florence Espinasse, Aurélien Dinh, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron
P166 Prophylactic confinement after liver transplant: a necessity or a useless precaution?
Benjamin Lebas, Sophie Hatsch, Quentin Maestraggi, Anne-Florence Dureau, Vincent Castelain, Bernard Ellero, François Faitot, Max Guillot, Francis Schneider
P167 Proteomic response and adaptation mechanisms of E. coli 536 to overcome the inhibitory effect of cranberry proanthocyanidins
Dimitri Margetis, Odile Bouvet, Didier Chevret, Didier Dreyfuss, Erick Denamur, Jean-Damien Ricard
P168 Is daily measurement of CRP useful to detect earlier ventilator-associated pneumonia?
Justine Simonet, Mathieu Boutonnet, Jean-Louis Daban, Elisabeth Falzone, Guillaume Dumas, Philippe Vest, Vincent Peigne
P169 Clinical and biological features of healthcare-associated coagulase-negative Staphylococci meningitis: results of a retrospective study
Severine Couffin, David Lobo, Gilles Dhonneur, Roman Mounier
P170 Prognostic value of electrocardiographic abnormalities in patients with acute pulmonary embolism
M. Cheikh Bouhlel, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y. Hamdaoui, Jihene Ayachi, W. Brahim, Rania Bouneb, Mohamed Boussarsar
P171 Does mean arterial pressure alarm improve the time spent within blood pressure target range in septic shock? A before and after study
Nans Florens, Martin Cour, Julie Varéon, Arnaud Malatray, Romain Hernu, Laurent Argaud
P172 Respiratory change of pulse pressure is not indicative of preload reserve in cardiac surgery patients
Pierre Dupland, Thomas D’humières, Romain Vergier, Pauline Issaurat, Philippe Estagnasié, Pierre Squara, Alain Brusset
P173 Importance of diastolic arterial pressure to optimize pulse pressure variation performances for patients receiving norepinephrine
Vincent Génin, David Vandroux, Cyril Ferdynus, Arnaud Roussiaux, Jérôme Allyn, Nicolas Allou, Olivier Martinet, Julien Jabot
P174 Multi-parameter monitoring for tissue perfusion in septic shock: correlations between macrohemodynamic and metabolic parameters: Preliminary results
Ali Jendoubi, Rifka Jlassi, Bassem Hamrouni, Yahia Marzougui, Jihen Kouka, Salma Ghedira, Mohamed Houissa
P175 Correlation between changes in levels of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and weight before and after dialysis
Kaouther Dhifaoui, Zied Hajjej, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P176 Impact of colonization with multidrug-resistant bacteria on the outcome of patients with hematological malignancies admitted to the intensive care medicine
Johanna Oziel, Carole Schwebel, Elie Azoulay, Michaël Darmon, Bertrand Souweine, Lila Bouadma, Guillaume Marcotte, Christophe Clec’h, Yves Cohen, Outcomerea Study Group
P177 ICU moving followed by a drop of imipenem-resistant Pseudomonas aeruginosa
Alexy Tran Dinh, Caroline Neulier, Marlène Amara, Nicaise Nebot, Gilles Troché, Nelly Breton, Benjamin Zuber, Sébastien Cavelot, Béatrice Pangon, Jean Pierre Bedos, Jacques Merrer, David Grimaldi
P178 Risk factors of carbapenem resistance acquisition in intensive care unit
François Labaste, Jean-Marie Conil, Julia Grossac, Stéphanie Ruiz, Marion Grare, Olivier Fourcade, Vincent Minville, Bernard Georges
P179 Risk factors for subsequent infection among patients with extended-spectrum beta-lactamase-producing enterobacteriaceae colonization: a retrospective study
Guillaume Van Der Meersch, Johanna Oziel, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Philippe Karoubi, Christophe Huang, Christophe Clec’h, Yves Cohen
P180 Is rectal colonisation predictive of extended-spectrum β-lactamase-producing enterobacteriaceae presence in respiratory samples performed in the intensive care unit?
Helene Carbonne, Matthieu Le Dorze, Rishma Amarsy, Joaquim Mateo, Didier Payen de la Garanderie
P181 Antibiotic therapy in intensive care unit patients: appraisal of medical attitude related to therapy appropriateness, severity of infection and outcome
Sophie Leloup Von Edelsberg, Christelle Vercheval, Monique Nys, Pierre Damas
P182 Epidemiology and associated factors of ICU-acquired infections in critically ill patients: a prospective cohort study
Zied Hajjej, Chaker Bouguerra, Noura Naas, Walid Sammoud, Iheb Labbene, Mustapha Ferjani
P183 The impact of nosocomial infection acquired in intensive care units on mortality and length of stay until hospital discharge: a retrospective, monocentric, 10-year study
Joris Muller, François Severac, Mickael Schaeffer, Pierre Tran Ba Loc, Stéphanie Deboscker, Maleka Schenck, Marie-Line Harley, Ralf Janssen-Langenstein, Jean-Etienne Herbrecht, Benjamin Lebas, Max Guillot, Vincent Castelain, Francis Schneider, Thierry Lavigne
P184 Incidence and prognosis of catheter-associated urinary tract infections in intensive care unit: the IPRIUS study
Jennifer Brunet, Bertrand Canoville, Cédric Daubin, Amélie Seguin, Nicolas Terzi, Xavier Valette, Pierre Verrier, Damien Du Cheyron
P185 Automatic tube compensation during mechanical ventilation in ICU patients. Meta-analysis of trials on weaning outcome and physiologic effects
Alina Stoian, Claude Guérin
P186 Automated oxygen titration during high-flow oxygen therapy. Evaluation of the feasibility in healthy subjects
François Lellouche, Erwan L’her, Pierre Alexandre Bouchard, Mathieu Delorme, Tamer Elfaramawy, Benoit Gosselin
P187 Accuracy of ventilators for intermediate care to deliver tidal volume. A bench study
Claude Guérin, Loredana Baboi, Sarah Guegan, Fabien Subtil
P188 Efficiency of ventilators for intermediate care to deliver adequate FIO2. A bench study
Claude Guérin, Loredana Baboi, Fabien Subtil, Sarah Guegan
P189 In vitro comparison of inspiratory-synchronized and continuous nebulization modes during noninvasive ventilation: analysis of inhaled and lost doses
Jean-Bernard Michotte, Enrico Staderini, Jonathan Dugernier, Rares Rusu, Jean Roeseler, Giuseppe Liistro, Gregory Reychler
P190 Short-term physiological effects of nasal high flow in patients with respiratory distress. Impact of flow rates on the work of breathing
Mathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François Lellouche
P191 Design and implementation of an active artificial lung
Elmaati Essoukaki, Lhoucine Ben Taleb, Mohammed Harmouchi, Mourad Rattal, Ahmed Mouhsen, Jean-Christophe Marie Richard, A Zeddine Mouhsen, Aissam Lyazidi
P192 Assessment of the accuracy of ventilator simulation softwares
Frédéric Duprez, Jean Bernard Michotte, Olivier Contal, Thierry Bonus, Sandra Olieuz, Grégory Cuvelier, Sharam Machayeckhi
P193 Outcome and early prognostic factors in neutropenic patients admitted to the intensive care unit
Becem Trabelsi, Zied Hajjej, Walid Sammoud, Hedi Garsallah, Mustapha Ferjani
P194 Blood loss and transfusion practice in medical surgical intensive care unit: 1-year study
Walid Sammoud, Zied Hajjej, Khaoula Harira, Hedi Garsallah, Mustapha Ferjani
P195 Atypical hemolytic and uremic syndrome in critically ill adult patients
Elie Azoulay, Akli Chermak, Cédric Rafat, Claire Pichereau, Emmanuel Canet, Virginie Lemiale, Valade Sandrine, Marion Venot, Benoît Schlemmer, Eric Mariotte
P196 Outcome of critically ill patients after allogeneic hematopoietic stem cell transplantation: comparison of cord blood cells with others cells as hematopoietic stem cells source
Caroline Le Jeune, Florent Wallet, Pascal Roy, Laurent Argaud, Mauricette Michallet
P197 Outcome of patients with organ failures related to solid malignancies and receiving chemotherapy in the intensive care unit
Yoann Zerbib, Julien Maizel, Naïke Bigé, Benoit Misset, Nicolas de Prost, Virginie Lemiale, Sylvie Ricome, François Baudin, Muriel Fartoukh, Frédéric Jacobs, François Blot, Matthieu Schmidt, Antoine Rabbat, Julien Mayaux, Frédéric Gonzalez, Caroline Bornstain, Elie Azoulay, Frédéric Pène
P198 Characteristics and outcomes of patients with hematological malignancies (HMs) admitted to the intensive care unit
Stéphanie Gelinotte, Dorothée Carpentier, Steven Grange, Julien Abily, Marion Beuzelin, Emmanuel Besnier, Gioia Gastaldi, Gaetan Beduneau, Jean-Philippe Rigaud, Christophe Girault, Fabienne Tamion
P199 Influence of neutropenia on mortality of critically ill cancer patients: Results of a systematic review and meta-analysis of available evidences
Marie Bouteloup, Sophie Perinel Ragey, Elie Azoulay, Djamel Mokart, Michaël Darmon, Groupe de Recherche en Réanimation Respiratoire et Onco-Hematologique (GRRROH)
P200 Thrombotic Microangiopathy (TMA) Syndromes in the ICU: experience of a Tunisian ICU
Jihene Ayachi, Ahmed Khedher, Kaoula Meddeb, A. Azouzi, Y Hamdaoui, H. Nouira, Rania Bouneb, Mohamed Boussarsar
P201 “Immunonutrition” failed to improve septic shock-induced vascular dysfunction in a rat model
Julie Boisramé-Helms, Grégory Meyer, Su Degirmenci, Mélanie Burban, Valérie Schini-Kerth, Alexandra Boivin, Raphaël Clere-Jehl, Alexandra Monnier, Christine Kummerlen, Ferhat Meziani
P202 PTP1B gene deletion improves glucose metabolism and limits cardiovascular dysfunction in experimental septic shock
Eugénie Delile, Pierre-Alain Thiébaut, Jean-Claude Do Rego, David Coquerel, Rémi Nevière, Vincent Richard, Fabienne Tamion
P203 Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis
Laure Ichou, Nicolas Carbonell, Pierre-Emmanuel Rautou, Ludivine Laurans, Simon Bourcier, Claire Pichereau, Jean-Luc Baudel, Jean-Baptiste Nousbaum, Christophe Renou, Rodolphe Anty, Jacques Tankovic, Eric Maury, Bertrand Guidet, Luce Landraud, Hafid Ait-Oufella
P204 Modulation of inflammatory response related to severe peritonitis by polymyxin-B hemoperfusion
Remi Coudroy, Jean-Claude Lecron, Didier Payen de la Garanderie, René Robert, ABDOMIX Group
P205 Descriptive study of ultrasonographic data inside a surgical intensive care unit for cholestasis diagnosis: dechorea study
Michael Helary, Jonathan Paillot, Sebastien Pili-Floury
P206 In-hospital mortality and predictive risk factors for patients with cirrhosis
Sana Khedher, Amira Maoui, Asma Ezzamouri, Mohamed Salem
P207 CONSTIPREA: evaluation of the management of constipation in intensive care—National Survey of French intensivits
Lamia Kerdjana, Mihaela Dumitrescu, Olivier Mimoz, Bertrand Debaene, Virginie Migeot, Claire Dahyot-Fizelier
P208 Corrosive ingestion in adults: endoscopic findings and agents involved
Sana Khedher, Asma Ezzamouri, Amira Maoui, Mohamed Salem, Amira A. Maoui
P209 Hypoxic hepatitis after out-of-hospital cardiac arrest: incidence, determinants and prognosis
Benoit Champigneulle, Guillaume Geri, Wulfran Bougouin, Florence Dumas, Michel Arnaout, Lara Zafrani, Frédéric Pène, Julien Charpentier, Jean-Paul Mira, Alain Cariou
P210 Aspiration pneumonitis in comatose patients treated with invasive mechanical ventilation. The SPIRE prospective survey
Jean-Baptiste Lascarrou, Floriane Lissonde, Aurélie Le Thuaut, Konstantinos Bachoumas, Gwenhaël Colin, Matthieu Henry-Laguarrigue, Maud Fiancette, Jean-Claude Lacherade, Christine Lebert, Isabelle Vinatier, Aihem Yehia, Aurélie Joret, Laurent Martin-Lefèvre, Jean Reignier
P211 Ventilator-associated pneumonia (VAP) in cancer patients: impact of 1-year survival
Laura Platon, Jerôme Lambert, David Lagier, Jeanpaul Brun, Antoine Sannini, Laurent Chow-Chine, Magali Bisbal, Marion Faucher, Djamel Mokart
P212 High-resolution computed tomography (HRCT) patterns in patients with pneumocystis pneumonia
Leïla Mourtada, Lemiale Virgnie, Claire Givel, Valade Sandrine, Claire Pichereau, Emmanuel Canet, Eric Mariotte, Elie Azoulay
P213 Plasma endocan predicts the occurrence of acute respiratory distress syndrome (ARDS) in severe sepsis and septic shock patients
Alexandre Gaudet, Erika Parmentier-Decrucq, Nathalie De Freitas Caires, Sylvain Dubucquoi, Philippe Lassalle, Daniel Mathieu
P214 Comparison of 3 diagnostic methods to identify fluid responsiveness during prone position in ARDS
Jean-Christophe Richard, Hodane Yonis, Florent Gobert, Romain Tapponnier, Claude Guérin
P215 Low pressure support-high PEEP for early severe acute respiratory distress syndrome: a retrospective analysis
Luc Quintin, C. Pichot, F. Petitjeans
P216 Neutrophil proteases alter the interleukin-22-receptor-dependent lung antimicrobial defence
Antoine Guillon, Youenn Jouan, Daborah Breah, Fabien Gueugnon, Emilie Dalloneau, Thomas Baranek, Clemence Henry, Eric Morello, Jc Renauld, M Pichavant, Philippe Gosset, Y Courty, Patrice Diot, Mustapha Si-Tahar
P217 Impaired phagocytosis of apoptotic neutrophils in human ARDS: beneficial effects of metformin
Fabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Yves Le Tulzo, Karin Tarte, Jean-Marc Tadié
P218 What are the deteP219 Emergency thoracotomy: development and results in a military trauma centerrminants of needle aspiration success in primary spontaneous pneumothorax?
Constance Vuillard, Jean-Damien Ricard, Béatrice La Combe, Stéphane Gaudry, Didier Dreyfuss, Jonathan Messika
P219 Emergency thoracotomy: development and results in a military trauma center
Pauline Ponsin, Jean-Louis Daban, Guillaume Boddaert, Bertrand Grand, Vincent Peigne, Yohan Baudoin, Mathieu Boutonnet, Patrick Jault, Stéphane Bonnet
P220 Management of isthmic aortic rupture in polytraumatized patients in ICU: a report of 12 cases
Chtara Kamilia, Kais Regaieg, Olfa Turki, Najeh Baccouch, Anis Chaari, Hmida Chokri Ben, Mabrouk Bahloul, Mounir Bouaziz
P221 NT-proBNP levels and echocardiography findings in the etiologic diagnosis of acute dyspnea
Salah Snouda, Hassen Ben Ghezala, Mohamed Fehmi Abbes, Rebeh Daoudi, Moez Kaddour, Imen Benchiekh
P222 Cardiac decompensation in peripartum
Kamal Belkadi, I. Moussaid, Chaigar Mohammed Cheikh, S. El Youssoufi, S. Salmi
P223 Peripheral intravenous catheter-related complications in an emergency ward
Ines Sedghiani, Hana Fredj, Hamdi Doghri, Youssef Zied El Hechmi, Mohamed Ali Cherif, Jerbi Zouheir
P224 Burnout in the emergency room
Neila Maaroufi, Abid Zeineb
P225 Prevalence, and characteristics of elderly patient admitted in a Moroccan Medical Unit for the Acute Care
Jihane Belayachi, Leila Debono, Naoufal Madani, Fatiha Amlaiky, Tarek Dendane, Khalid Abidi, Aicha Zekraoui, Amine Ali Zeggwagh, Redouane Abouqal
P226 Metabolic phenotyping in bronchoalveolar lavage fluids distinguishes influenza and pneumococcal pneumonia
Adrien Auvet, Antoine Guillon, Lydie Nadal-Desbarats, Thomas Baranek, Eric Morello, François Réminiac, Mustapha Si-Tahar
P227 Microbiological documentation of pneumonia in the ICU by per-bronchoscopic bronchial aspiration (PBA) is very similar to that obtained by bronchoalveolar lavage (BAL)
Jean-Luc Baudel, Jacques Tankovic, Redouane Dahoumane, Arnaud Galbois, Hafid Ait Oufella, Georges Offenstadt, Eric Maury, Bertrand Guidet
P228 Compliance with the H3 bundle of the 2012 surviving sepsis campaign according to the chain of care of septic patients: the sepsis CHOC study
Amel Filali, Emmanuel Faure, Nicolas Van Grunderbeeck, Olivier Nigeon, Juliette Masse, H Bazus, Jihad Mallat, Didier Thevenin
P229 CRP ratio as a predictive tool for mortality in ICU septic patients
Sophie Lempereur-Legros, Didier Ledoux, Monique Nys, Pierre Damas
P230 Candidemia in ICU: Epidemiology and prognostic factors
Zied Hajjej, Walid Sammoud, Becem Trabelsi, Iheb Labbene, Mustapha Ferjani
P231 Extracorporeal membrane oxygenation cannula-associated infections: implication of virulent Escherichia coli phylogroups
Jonathan Messika, Olivier Clermont, Matthieu Schmidt, Alexandra Aubry, Romain Fernandes, Erick Denamur, Alain Combes, Jean-Damien Ricard
P232 Is diabetes mellitus a risk factor for intensive care unit-acquired infections in intensive care unit patients with hematologic malignancies?
Marion Venot, Sylvie Chevret, Djamel Mokart, Frédéric Pène, Virginie Lemiale, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Elie Azoulay
P233 Should we need aerobic–anaerobic or specific blood culture bottles for diagnosing candidemia in ICU patients?
Sébastien Bailly, Jean-François Timsit, Cécile Garnaud, Muriel Cornet, Patricia Pavese, Rebecca Hamidfar-Roy, Luc Foroni, Sandrine Boisset, Carole Schwebel, Danièle Maubon
P234 Invasive Candida infection in a Tunisian ICU: an observational cohort study
Islem Ouanes, Maha Abid, Hend Ben Lakhal, Saousen Ben Abdallah, Fahmi Dachraoui, Hedia Hammed, Rami Jabla, Asma Hachani, Mahdi Marzouk, Imen Abdellaoui, Chaima Ghribi, Imen Ben Ali, Lamia Ouanes-Besbes, Fekri Abroug
P235 Causes of admission in medical intensive care of patients suffering from severe psychiatric disorders
Hanane Ezzouine, Constant Aniolo Edith, Abdellatif Benslama
P236 Unplanned extubation in critical care: still to learn from local survey
Frédéric Jacobs, Dominique Prat, Matthieu Le Meur, Olfa Hamzaoui, Anne Sylvie Dumenil, Guy Moneger, Nadège Demars, Pierre Trouiller, Benjamin Sztrymf
P237 Mortality associated with nights and weekends admission to intensive care unit (ICU): results of a 9-year cohort study (2006–2014)
Vincent Brunot, Jean-Emmanuel Serre, P. Corne, Nicolas Molinari, L. Landreau, Olivier Jonquet, Kada Klouche
P238 Determinants and outcomes associated with decisions to deny admission in a Tunisian ICU
Rania Bouneb, Kaoula Meddeb, Y. Hamdaoui, H Nouira, A. Azouzi, Jihene Ayachi, Ahmed Khedher, Mohamed Boussarsar
P239 Characteristics and outcomes of patients not admitted to ICU
Nesrine Boujelbene, Rami Jabla, Fahmi Dachraoui, Islem Ouanes, Mahdi Marzouk, Hedia Hammed, Asma Hachani, Hend Ben Lakhal, Chaima Ghribi, Imen Abdellaoui, Imen Ben Ali, Saousen Ben Abdallah, Lamia Ouanes-Besbes, Fekri Abroug
P240 Long-term outcomes of critically ill patients with severe acute kidney injury requiring renal replacement therapy
Vanessa Jean-Michel, Francis Couturaud, Elizabeth Moore, Pierre-Yves Egreteau, Jean-Michel Boles, Cécile Aubron
P241 Nowadays, SAPSII better predicts 1-year mortality than hospital mortality
Jean-Etienne Herbrecht, Max Guillot, Quentin Maestraggi, Charlotte Kaeuffer, Ralf Janssen-Langenstein, Sylvie L’hotellier, Sophie Hatsch, Benjamin Lebas, Alexandra Boivin, Maleka Schenck, Marie-Line Harlay, Anne Meyer, Vincent Castelain, Francis Schneider
P242 Impact of diabetes on burn injury: preliminary results from retrospective study
Amel Mokline, Imen Rahmani, Khaouther Ben Arfi, Lazhari Gharsallah, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Amen Allah Messadi
P243 Withdrawal or withholding of life-sustaining treatments decisions: Is there a risk of excessive influence of medical imaging?
Fabrice Lesage, Sylvie Séguret, Laurent Dupic, Laure De Saint Blanquat, Sylvain Renolleau
P244 Withholding and withdrawal of life-sustaining treatments in intensive care unit patients: predisposing factors and implementation
Anne-Sophie Baptiste, Hugues Georges, Pierre-Yves Delannoy, Patrick Devos, Olivier Leroy
P245 Advanced directives in an old patient with suicide attempt: analysis of ICU physicians perception
Dolores Albarracin, A. Ducousso-Lacaze, Angéline Jamet,, Julien Dufour, Séverin Cabasson, Anne Veinstein, Delphine Chatellier, Jean-Pierre Frat, René Robert
P246 Having the talk about advance directives in the daily practice: Is a stay in an intensive care unit a good opportunity?
Vivien Hong Tuan Ha, Nicolas Lau, Lucie Mimoun, Xavier Forceville
P247 Long-term outcome of patients who have withheld life support in intensive care
Adel Maamar, Stéphanie Chevalier, Vlad Botoc, Yves Le Tulzo
P248 Epidemiology of refusals in a polyvalent intensive care unit ad outcome of refused patients
Stephane Rouleau, David Schnell, Arnaud Desachy, Sylvie Calvat, Philippe Petua, Charles Lafon, Christophe Cracco
P249 Ten critical sentences you have already heard in the Intensive Care Unit and the Emergency Department, their real meanings and consequences
Nicolas Van Grunderbeeck, J. Temime, Perrine Molmy, Stephanie Barrailler, G. Gasan, Olivier Nigeon, Didier Thevenin
P250 Communication with the parents: a challenge in the pediatric intensive care unit
Agathe Béranger, Charlotte Pierron, Laure De Saint Blanquat, Sandrine Jean, Hélène Chappuy
P251 End of life in the intensive care unit: between practice and knowledge
Pierre-Marie Bertrand, Alexandra Beurton, Laetitia Bodet-Contentin, Julie Boisramé-Helms, Pierre-éRic Danin, Elsa Dubois, Elodie Gélisse, Yasemin Karaca, Pierre Mora, Nicolas de Prost, Damien Roux, Alexis Soummer, Dominique Vodovar, Committee of young intensivists of the French Society for Intensive Care Medicine (FICS)
S1 The HICU Score (Hematologic Intensive Care Unit Score): a new prognostic score for predicting 30-day and 1-year mortality of patients with hematologic malignancies admitted in ICU
Yohan Desbrosses, Guylaine Labro, Gaël Piton, Adrien Chauchet, Etienne Daguindau, François Blot, Eric Deconinck, Gilles Capellier
S2 Patients with multiple myeloma in the ICU: trends of use and outcomes over time
Akli Chermak, Adrien Joseph, Virginie Lemiale, Claire Pichereau, Marinne Baron, Emmanuel Canet, Eric Mariotte, Michaël Darmon, Elie Azoulay
S3 Impact of bone marrow aspiration on the management of adult critically ill patients
Laure Calvet, Anne Françoise Sapin, Bruno Pereira, Alexandre Lautrette, Bertrand Souweine
S4 Red blood cells transfusion in ICU: descriptive analysis of French cohort from “Age BLood Evaluation” clinical trial
Lucie Vettoretti, Sebastien Pili-Floury, Gaël Piton, Jacques Lacroix, Lucy Clayton, Elham Sabri, Laurent Bardiaux, Pierre Tiberghien, Paul Hebert, Gilles Capellier, ABLE French Investigators
S5 Graft-versus-host disease trajectories and mortality in critically ill allogeneic stem cell recipients
Claire Pichereau, Etienne Lengliné, Anne-Sophie Moreau, Eric Mariotte, Marion Venot, Sandrine Valade, Akli Chermak, Virginie Lemiale, Emmanuel Canet, Gérard Socié, Benoît Schlemmer, Elie Azoulay
S6 Outcome of 544 patients with solid cancer in the intensive care unit: the Oncoréa study
Edith Borcoman, Virginie Lemiale, Eric Mariotte, Claire Pichereau, Emmanuel Canet, Adrien Joseph, Akli Chermak, Sandrine Valade, Marion Venot, Benoît Schlemmer, Elie Azoulay
S7 Assessing the process of ICU admission refusal in critically ill patients with hematological malignancies
Katerina Rusinova, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Antoine Rabbat, Frédéric Pène, Achille Kouatchet, Fabrice Bruneel, Julien Mayaux, François Vincent, Pierre Perez, Martine Nyunga, Elie Azoulay, Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie
S8 Neurologic and hepatic failures at ICU admission are associated with worst prognosis for patients with lymphomas
Aurélien Sutra Del Galy, Achille Kouatchet, Mélanie Mercier, Jean-François Hamel, Tommy Raveau, Marie-Pierre Moles, Aline Clavert, Mathilde Hunault-Berger, Alain Mercat, Norbert Ifrah, Aline Schmidt-Tanguy
S9 Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized polysomnographic study
Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf, Thomas Similowski
S10 Diaphragmatic paralysis after adult cardiac surgery: incidence and predicting factors
Thomas D’humières, Pierre Dupland, Pauline Issaurat, Romain Vergier, Philippe Estagnasié, Alain Brusset, Pierre Squara
S11 Ultrasound evaluation of diaphragmatic dysfunction: prognostic marker of ICU weaning failure
Cédric Carrié, Chloé Gisbert-Mora, Eline Bonnardel, Matthieu Biais, Frédéric Vargas, Gilles Hilbert
S12 A prospective multicentric study to evaluate the impact of breathing variability on clinical outcomes in mechanically ventilated patients
Côme Bureau, Camille Rolland-Debord, Tymothée Poitou, Marc Clavel, Sébastien Perbet, Nicolas Terzi, Achille Kouatchet, Thomas Similowski, Alexandre Demoule, Université Paris 6 —Pierre et Marie Curie and Institut National pour la Santé et la Recherche Médicale, UMRS1158, Paris
S13 Nurse-driven sedation protocol with sedation vacation and incidence of unplanned extubations
Pierre Lucas, Julien Charpentier, Michel Arnaout, Thomas Joannon,, Sébastien Lefort, Aude Marincamp, Anne-Sophie Debue, Matthieu Reffienna, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Working Group on Mechanical Ventilation
S14 Lung ultrasound enables to detect weaning-induced cardiogenic pulmonary oedema
Alexis Ferre, Max Guillot, Jean-Louis Teboul, Daniel Lichtenstein, Gilbert Meziere, Christian Richard, Xavier Monnet
S15 Pleural effusion during the weaning from mechanical ventilation: prevalence and impact
Damien Roux, Tai Pham, Alexandra Beurton, Muriel Fartoukh, Jean-Damien Ricard, Alexandre Demoule, Martin Dres
S16 Prognostic impact of left ventricular diastolic dysfunction in patients with septic shock
Céline Gonzalez, François Dalmay, Emmanuelle Begot, Nicolas Pichon, Bruno François, Anne-Laure Fedou, Catherine Chapellas, Antoine Galy, Philippe Vignon
S17 Norepinephrine exerts an inotropic effect at the early phase of human septic shock
Olfa Hamzaoui, Mathieu Jozwiak, Thomas Geffriaud, Benjamin Sztrymf, Dominique Prat, Frédéric Jacobs, Xavier Monnet, Pierre Trouiller, Christian Richard, Jean-Louis Teboul
S18 Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS: Is it good for the lung and for the heart?
Shari El-Dash, Loay Kontar, François Leleu, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Julien Maizel, Michel Slama
S19 Myocardial dysfunction during septic shock: prevalence, prognosis and role of loading conditions
Florence Boissier, Keyvan Razazi, Aurelien Seemann, Arnaud, W Thille, Nicolas de Prost, Elise Cuquemelle,, Filippo Boroli,, Alexandre Bedet, Pascal Lim, Christian Brun-Buisson, Armand Mekontso Dessap
S20 Echocardiography for the critically ill: 1-year experience of a noninvasive intensive care unit
W Brahim, R Amara, A Azouzi, Ahmed Khedher, Jihene Ayachi, Rania Bouneb, Y Hamdaoui, Kaoula Meddeb, Mohamed Boussarsar
S21 Echocardiographic indices to predict fluid responsiveness in ventilated patients with circulatory failure: which threshold for which aim?
Emmanuelle Begot, Xavier Repessé, Julie Léger, Gwenael Prat, Cyril Charron, Pierre-Yves Egreteau, Christophe Jacob, Koceila Bouferache, Loay Kontar, Julien Maizel, Michel Slama, Antoine Vieillard-Baron, Philippe Vignon
S22 Effects of norepinephrine on the right ventricle assessed by transthoracic echocardiography in the ICU
Claire Ragot, Laure Corradi, Frédéric Vargas
S23 Effect of recruitment maneuver on left ventricular systolic strain
Pablo Mercado, Julien Maizel, Loay Kontar, Bertand De Cagny, François Brazier, Dimitri Titeca, Gaelle Bacari-Risal, Antoine Riviere, Shari El-Dash, Michel Slama
S24 Management of diabetic ketoacidosis in two pediatric intensive care units: comparison of two care protocols
Laure Maurice, Stéphane Dauger, S Julliand, Anna Deho, Fleur Le Bourgeois
S25 NUTRI-REAPED: Nutritional status on admission to the pediatric intensive care unit—a French multicentric study
Aurelien Jacquot, Frederic Valla, Bénédicte Gaillard-Le Roux, Flavie Letois, Gilles Cambonie, NutriSIP
S26 Apnea test in children for brain death diagnosis: efficacy and complications
Alexandre Salvadori, Gaia Ottonello, Stéphane Blanot, Juliette Montmayeur, Gilles Orliaguet
S27 Interest of the ultrasound in the central venous catheterization in children poses in intensive care unit
Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled Benjazia
S28 Supraclavicular approach to the innominate vein in pediatric intensive care unit: interest in the prevention of thrombosis and catheter-related blood stream infection
Flora Habas, Julien Baleine, Julia Lebouhellec, Christophe Milesi, Clementine Combes, Gilles Cambonie
S29 EPURE Study: Preliminary results on the organization of pediatric acute dialysis in 2 French-speaking countries
Maryline Chomton, Philippe Jouvet, Bruno Ranchin, Marie Alice Macher, Théophile Gaillot, EPURE Study Group
S30 Hyperglycemia in severe scorpion envenomed children: incidence and impact outcome
Mabrouk Bahloul, Najeh Baccouche, Kais Regaieg, Turki Olfa, Chtara Kamilia, Benhamida Chokri, Hedi Chelly, Mounir Bouaziz
S31 Prehospital care and initial hospital care of pediatric patients with severe trauma hospitalized in the ICU at Grenoble University Hospital, data from the “TRENAU” trauma-system
Murielle Moine, François Xavier Ageron, Claire Jannel, Thierry Debillon, Isabelle Wroblewski
S32 Ventilator-associated pneumonia due to multi- or extensively drug-resistant Pseudomonas aeruginosa: comparison with susceptible strains
Matthieu Duprey, Nicolas Bréchot, Alexandra Aubry, Guillaume Hekimian, Matthieu Schmidt, Ania Nieszkowska, Jean Louis Trouillet, Vincent Jarlier, Alain Combes, Jean Chastre, Charles-Edouard Luyt
S33 Can we predict a secondary documented infection in patients empirically treated for an invasive candidiasis?
Sébastien Bailly, Olivier Leroy, Jean-Paul Mira, Hervé Dupont, Jean-Pierre Gangneux, Philippe Montravers, Jean-Michel Constantin, Didier Guillemot, Olivier Lortholary, Pierre-François Perrigault, Elie Azoulay, Jean-François Timsit
S34 Should aminoglycosides be administered to hematological patients with septic shock? Data from the Groupe de Recherche respiratoire en Réanimation Onco-Hématologique (Grrr-OH)
Thomas Longval, Sylvie Chevret, Fabrice Bruneel, Djamel Mokart, Frédéric Pène, Julien Mayaux, Achille Kouatchet, Martine Nyunga, Antoine Rabbat, Pierre Perez, Christine Lebert, Dominique Benoit, François Vincent, Virginie Lemiale, Elie Azoulay
S35 Is de-escalation of antimicrobial therapy safe in hematology patients?
David Schnell, Claire Montlahuc, Matthieu Resche-Rigon, Achille Kouatchet, Jean-Ralph Zahar, Michaël Darmon, Frédéric Pène, Virginie Lemiale, Antoine Rabbat, François Vincent, Fabrice Bruneel, Djamel Mokart, Elie Azoulay
S36 Pharmacokinetics and absolute bioavailability of voriconazole administered through a nasogastric tube with continuous enteral feeding to critically ill ventilated patients
Philippe Karoubi, Christophe Huang, Antoine Rabbat, Johanna Oziel, Guillaume Van Der Meersch, Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Christophe Clec’h, Christophe Padoin, Yves Cohen
S37 Which optimal daily dose for linezolid in burn patients?
Amel Mokline, Lazhari Gharsallah, Imen Rahmani, Emna Gaies, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Sameh Triki, Anis Klouz, Amen Allah Messadi
S38 Predictive factors of sub-therapeutic peak concentration after a single dose of amikacin in postoperative cardiovascular critically ill patients
Mouhamed Moussa, Flavie Desrumaux
S39 Supra-therapeutic serum levels and toxicity of beta-lactam antibiotics in septic ICU patients requiring replacement therapy for acute renal failure: a single-center cohort study
Faten May, Marion Perrin, Najoua El-Helali, Jean-Claude Nguyen, Kelly Tiercelet, Stephane Ruckly, Julien Fournier, Mélanie Cherin, Cédric Bruel, Francois Philippart, Maïté Garrouste-Orgeas, Marie Dominique Kitzis, Alban Le Monnier, Jean-François Timsit, Benoit Misset
S40 Post-cardiac arrest syndrome: lessons from a monocentric retrospective study
Cyrille Mathien, Antoine Poidevin, Luis Donatti, Joy Mootien, Luis Pinto, Mathieu Egard, Gokhan Bodur, Guillaume Barberet, Carmen Ionescu, Frederique Ganster, Philippe Guiot, Khaldoun Kuteifan
S41 Out-of-hospital cardiac arrest (OHCA) score for prediction of outcome of in-hospital cardiac arrest: results of the OSPICA pilot study
Alain Mpela, Jonathan Chelly, Jennifer Brunet, Stéphane Legriel, Laurent Guérin, Romain Persichini, Alexis Soummer, Bertrand Sauneuf, Tai Pham, Thomas Hullin, Nicolas Deye, Pierre Aubertein, Mehran Monchi
S42 Delayed awakening after cardiac arrest: causes and outcome in the Parisian registry
Marine Paul, Wulfran Bougouin, Guillaume Geri, Florence Dumas, Benoit Champigneulle, Stéphane Legriel, Julien Charpentier, Jean-Paul Mira, Claudio Sandroni, Alain Cariou
S43 Incidence and characteristics of sudden unexplained cardiac death: insights from the Parisian registry
Olivier Passouant, Guillaume Geri, Florence Dumas, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jonathan Chelly, Jean-Daniel Chiche, Olivier Varenne, Jean-Paul Mira, Alain Cariou
S44 Supranormal oxygen tension is not associated with an impaired redox balance in patients resuscitated from cardiac arrest
Jean-François Llitjos, Camille Chenevier-Gobeaux, Julien Charpentier, Florence Dumas, Guillaume Geri, Wulfran Bougouin, Benoit Champigneulle, Michel Arnaout, Jean-Paul Mira, Frédéric Pène, Frederic Batteux, Alain Cariou
S45 Impaired biological response to aspirin in comatose patients resuscitated from out-of-hospital cardiac arrest
Jean-François Llitjos, Ludovic Drouet, Sebastian Voicu, Nicolas Deye, Bruno Megarbane, Patrick Henry, Jean-Guillaume Dillinger
S46 Gender differences in coronary reperfusion after cardiac arrest
Wulfran Bougouin, Florence Dumas, Eloi Marijon, Guillaume Geri, Benoit Champigneulle, Jean-Daniel Chiche, Olivier Varenne, Christian Spaulding, Jean-Paul Mira, Xavier Jouven, Alain Cariou
S47 Prognostic factors of out-of-hospital cardiac arrests in Martinique: prospective study over a period of 29 months, about 385 cases
Dabor Resiere, A. L. Dessoy, Ruddy Valentino, C. Chabartier, Laurent Villain-Coquet, Jean-Louis Ferge, Y. Brouste, Bruno Megarbane, Hossein Mehdaoui
S48 Incubation of immune cells in septic plasma: effect on glucose utilization and on phenotypic expression on monocytes, polymorphonuclears and lymphocytes
Benjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
S49 Ex vivo effects of hyperglycemia on phenotype and production of reactive oxygen species by the NADPH oxidase of human immune cells in acute inflammatory response
Benjamin Soyer, Valérie Faivre, Charles Damoisel, Anne-Claire Lukaszewicz, Didier Payen de la Garanderie
S52 HMGB1 induces neutrophils dysfunction after septic shock
Fabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Caroline Piau, Yves Le Tulzo, Karin Tarte, Jean-Marc Tadié
S53 Rapid mobilization of myeloid-derived suppressor cells during sepsis and relation with clinical course
Thomas Daix, Robin Jeannet, Emmanuelle Begot, Nicolas Pichon, Anne-Laure Fedou, Estelle Guérin, Philippe Vignon, Jean Feuillard, Bruno François
S54 Targeted endothelial TREM-1 deletion protects mice during septic shock
Lucie Jolly, Amir Boufenzer, Jérémie Lemarie, Kevin Carrasco, Marc Derive, Sebastien Gibot
S55 Polymicrobial sepsis inhibits tumor growth in cancer mice
Hamid Merdji, Jean-François Llitjos, Christophe Rousseau, Nadia Belaidouni, Julie Toubiana, Jean-Paul Mira, Jean-Daniel Chiche, Frédéric Pène
S56 Telestroke implementation in the biggest French region (12 millions inhabitants): the project ORTIF
Yann L’Hermitte, France Woimant, Catherine Oppenheim, Christophe Couvreur, François Dolveck
S57 Free haemoglobin concentration in patients with sickle cell disease referred to the emergency room: Is it useful?
Pierre Mora, Magali Devriese, Sophie Dupeyrat, Patrick Ray, Guillaume Lefevre, Muriel Fartoukh
S58 Evaluation of the prescription and use of antibiotics in an emergency department of a general hospital by Gyssens Method
Nicolas Roothaer, Amélie Carpentier, Fabien Vaniet, Antoine Maisonneuve, Eric Wiel
S59 High dosages of norepinephrine in trauma patients
Sébastien Canu, Emmanuelle Hammad, Francois Antonini, Marion Poirier, Laurent Zieleskiewicz, Coralie Vigne, Malik Haddam, Julie Alingrin, Marc Leone
S60 Bleeding risk of pleural procedures in patients taking antiplatelet therapy: a multicentric prospective study
Laurence Dangers, Gilles Mangiapan, Mikael Alves, Naïke Bigé, Jonathan Messika, Elise Morawiec, Mathilde Neuville, Christophe Cracco, Gaetan Beduneau, Nicolas Terzi, Isabelle Huet, Xavier Dhalluin, Nathalie Bautin, Jean Jacques Quiot, Corinne Appere De Vecchi, Thomas Similowski, Cécile Chenivesse
S61 Interest of the association fibrinogen/tranexamic acid in the management of severe postpartum hemorrhage
Khalil Tarmiz, Fehmi Ferhi, Hosni Khouadja, Affra Brahim, Mohamed Amine Bouslama, Khaled Benjazia
S62 HELLP syndrome in ICU: epidemiological, clinical and prognostic study about 112 cases
Fatma Kaaniche Medhioub, Kais Rgieg, Olfa Turki, Mariem Smaoui, Anis Chaari, Benhamida Chokri, Mabrouk Bahloul, Bouaziz Mounir
S63 Neurological complications in eclampsia
Chaigar Mohammed Cheikh, I. Moussaid, Kamal Belkadi, E. El Alami, S. El Youssoufi, S. Salmi
S64 Brain water contain is dependent on plasmatic ammonemia levels in hyperammoniemic encephalopathy, a quantitative CT scan study
Nicolas Weiss, Fanny Mochel, Damien Galanaud, Louis Puybasset, Dominique Thabut, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, France
S65 Sodium phenylbutyrate administration to avoid neurological worsening in hepatic encephalopathy patients in ICU
Simona Tripon, Marion Lodey, Elsa Guiller, Maxime Mallet, Marika Rudler, Dominique Thabut, Nicolas Weiss, Brain Liver Pitié-Salpêtrière Study Group (BLIPS), Paris, France
S66 Disruption of posteromedial large-scale neural communication predicts recovery from coma
Stein Silva, Béatrice Riu-Poulenc, Jean Ruiz, Corine Vuillaume, Francesco De Pasquale, Jean Francois Demonet
S67 Loss of sleep elements on continuous EEG monitoring is associated with mortality in patients with cardiogenic shock requiring veno-arterial extra-corporeal membrane oxygenation (ECMO)
Fabrice Sinnah, Marie Amelie Dalloz, Eric Magalhaes, Mathilde Neuville, Roland Smonig, Aguila Radjou, Bruno Mourvillier, Lila Bouadma, Jean-François Timsit, Marie Pia D’ortho, Anny Rouvel-Tallec, Romain Sonneville
S68 Protective effects of high-density lipoprotein therapy in a mouse model of ischemic stroke hemorrhagic transformation due to acute hyperglycemia
David Couret, Aurélie Catan, Brice Nativel, Cynthia Planesse, Nicolas Diotel, Olivier Meilhac
S69 Glucocorticoids as a “rescue therapy” for delayed intracranial hypertension after acute brain injury: a retrospective study
Fabian Roy-Gash, Stephane Welschbillig, Elodie Lang, Christophe Lebard, Nicolas Engrand
S70 Organ donation: early talks (ET) to relatives before occurence of brain death
Anne-Gaelle Si Larbi, Virginie Gaudin, France Bonnin, Oceane Sultan,, Alexis Soummer, Grégoire Trebbia, Cecile Hoc, Emmanuel Mathieu, Bertrand Lapergue, Frederic Bourdain, Charles Cerf
S71 Remifentanil target-controlled infusion for procedures generating pain or discomfort in the ICU: feasibility, safety and tolerance evaluation
Margot Caron, Antoine Parrot, Maxens Decavèle, Clarisse Blayau, Jean-Pierre Fulgencio, Vincent Labbe, Michel Djibre, El Mahdi Hafiani, Christophe Quesnel, Muriel Fartoukh, Tai Pham
S72 Minimizing dead-volume infusion devices leads to a reduction in hypoglycaemia in surgery patients admitted to a perioperative intensive care unit
Stephanie Genay, Bertrand Décaudin, Sabine Ethgen, Pascal Odou, Gilles Lebuffe
S73 Patient-important outcomes in randomized controlled trials in critically ill patients
Stéphane Gaudry, Jonathan Messika, Jean-Damien Ricard, Blandine Pasquet, Sylvie Guillo, Emeline Dubief, Didier Dreyfuss, Florence Tubach
S74 Epidemiology of platelets transfusion in critically ill patients
Cécile Aubron, Andrew Flint, Michael Bailey, Rinaldo Bellomo, David Pilcher, Allen Cheng, Colin Hegarty, Anthony Martinelli, Benjamin Howden, Michael Reade, Zoe Mcquilten
S75 Outcome of selected nonagenarians admitted in ICUs: a multicenter study from the Outcomerea research group
Maïté Garrouste-Orgeas, Stephane Ruckly, Francois Philippart, Anne Sylvie Dumenil, Dany Goldgran Toledano, Samir Jamali, Carole Schwebel, Lilia Soufir, Christophe Clec’h, Michaël Darmon, Bernard Allaouchiche, Laurent Argaud, Bruno Verdière, Muriel Fartoukh, Mélanie Cherin, Elie Azoulay, Jean-François Timsit
S76 A systematic follow-up consultation guarantee quality of care in intensive care unit
Martine Nyunga, Noémie Banaias, Clément Vanbaelinghem, Céline Broucqsault-Dedrie, Delphine Colling, Marie Kauv, Erik Blondeau, Patrick Herbecq
S77 Change in functional autonomy following ICU stay
Islem Ouanes, Mahdi Marzouk, Lamia Ouanes-Besbes, Rami Jabla, Chaima Ghribi, Nesrine Boujelbene, Asma Hachani, Saousen Ben Abdallah, Hedia Hammed, Hend Ben Lakhal, Imen Ben Ali, Imen Abdellaoui, Fahmi Dachraoui, Fekri Abroug
S78 Outcome of Intensive Care Unit (ICU) elderly patients admitted with solid tumor
Edouard Auclin, Emmanuel Guérot, Caroline Haw-Berlemont, Julien Taieb, Stéphane Oudard, Jean-Luc Diehl, Jean-Yves Fagon, Nadia Aissaoui
S79 Risks factors for mortality in critically ill children with acute kidney injury requiring renal replacement therapy
Genevieve Morissette, Wassim Kechaou, Catherine Litalien, Aïcha Merouani, Véronique Phan, Josée Bouchard, Philippe Jouvet
S80 Epinephrine use in pediatric septic shock: a retrospective, single-center study on 117 patients
Julie Starck, Mehdi Oualha, Nelly Briand, Jean-Marc Treluyer, Sylvain Renolleau, Laurent Dupic
S81 Sickle cell disease in pediatric intensive care unit: a five-year retrospective monocentric study of 74 patients
Philippe Sachs, S Julliand, François Angoulvant, Julie Sommet, L Holvoet, M Benkerrou, Stéphane Dauger
S82 Implementation and evaluation of a paediatric nurse-driven sedation protocol in a PICU
Lélia Dreyfus, Fabienne Bordet, Sandrine Touzet, Angélique Denis, Etienne Javouhey
S83 Diagnostic evaluation and management of new-onset seizures and seizures with known epilepsy in children: a retrospective and comparative analysis
Julien Le Coz, Gérard Chéron, Rima Nabbout, Geraldine Patteau, Claire Heilbronner, Philippe Hubert, Sylvain Renolleau, Mehdi Oualha
S84 MRI sedation in children in pediatric hospital in Oran, Algeria
Nabil Tabet Aoul, zakaria addou, Ali Douah, Mohamed Moussati, Kamel Belhabiche, Nabil Aouffen
S85 Neurally adjusted ventilatory assist in pediatric patients following cardiac surgery: feasibility in clinical practice and impact on ventilation pressures
Benjamin Crulli, Baruch Toledano, Nancy Poirier, Suzanne Vobecky, Guillaume Emeriaud
S86 Percutaneous central venous cannulation: a Seldinger technique versus an ultrasound guidance technique in a pediatric intensive care unit
Fehmi Ferhi, Hosni Khouadja, Mohamed Amine Bouslama, Affra Brahim, Khalil Tarmiz, Khaled Benjazia
S87 Effect of remote ischemic preconditioning on renal resistive index in healthy volunteers
René Robert, M. Vinet, Angéline Jamet, Remi Coudroy, Arnaud W. Thille
S88 Peak concentration of high-dose AMIKACIN does not affect renal recovery at day 90: a retrospective study of 93 patients in a single medical Intensive Care Unit
Camille Vinclair, Romain Sonneville, Bruno Mourvillier, Mathilde Neuville, Roland Smonig, Eric Magalhaes, Guillaume Voiriot, Aguila Radjou, Jean-François Soubirou, Stephane Ruckly, Lila Bouadma, Jean-François Timsit
S89 Resuscitating chronic hypertensive patient with a high mean arterial pressure target during septic shock protects against acute renal failure
Julie Boisramé-Helms, Ferhat Meziani, Jean-François Hamel, François Beloncle, Jean-Louis Teboul, Peter Radermacher, Pierre Asfar
S90 Guidewire exchange vs new-site placement for temporary dialysis catheters insertion in ICU patients: Is there a greater risk of colonization or dysfunction?
Elisabeth Coupez, Jean-François Timsit, Stephane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohé, Maïté Garrouste-Orgeas, François Vincent, Sophie Cayot, Michaël Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand Souweine
S92 Assessment of chloride levels on renal function after cardiac arrest
Cláudia Righy Shinotsuka, Pietro Caironi, Paola Villois, Vito Fontana, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
S93 Sustained low-efficiency dialysis with regional citrate anticoagulation is safe for patients with acute liver failure or cirrhosis
Franck Pourcine, Ly Vong, Jonathan Chelly, Sebastien Jochmans, Oumar Sy, Olivier Ellrodt, Nathalie Rolin, Jean-Emmanuel Alphonsine,, Claire Marie Weyer, Jean Serbource-Goguel, Benoit Akando, Razach Abdallah, Mehran Monchi, Christophe Vinsonneau
S94 The new biomarker Nephrocheck™ can discriminate the population of septic shock patients with an AKIN 1 or 2 acute renal failure who will not progress toward the AKIN 3 level
Morgane Wetzstein, Loay Kontar, Dimitri Titeca, François Brazier, Bertand De Cagny, Gaelle Bacari-Risal, Antoine Riviere, Michel Slama, Julien Maizel
S95 Is thrombocytopenia an early prognostic marker in septic shock?
Nadiejda Antier, Christine Binquet, Sandrine Vinault, Ferhat Meziani, Julie Boisramé-Helms, Jean-Pierre Quenot
S96 Assessment of fibrinolysis in critically ill patients
Yasmina Serroukh, Karim Zouaoui Boudjeltia, Anne Joosten, Alexandre Rousseau, Patrick Biston, Michael Piagnerelli
S97 Early detection of disseminated intravascular coagulation during septic shock: a multicentre prospective study
Xavier Delabranche, Jean-Pierre Quenot, Thierry Lavigne, Emmanuelle Mercier, Bruno François, François Severac, Lélia Grunebaum, Laure Stiel, Florence Toti, Ferhat Meziani, Julie Boisramé-Helms, CRICS Network
S98 Activation or dysregulation of coagulation during septic shock: How to stratify patients in 2016?
Xavier Delabranche, Thierry Lavigne, Laure Stiel, Julie Boisramé-Helms, Achille Kouatchet, Maleka Schenck, Lélia Grunebaum, Yoganaden Mootien, Nicolas Lerolle, Ferhat Meziani
S99 Associated factors to early high blood pressure after weaning vasopressors during septic shock
Rostane Gaci, Jean-Romain Garric, Damien Barraud, Marie Conrad, Aurélie Cravoisy-Popovic, Jérémie Lemarie, Charles-Henri Maigrat, Pierre-Edouard Bollaert, Sébastien Gibot
S100 Impact of endotracheal intubation on septic shock outcome: a post hoc analysis of the SEPSISPAM trial
Agathe Delbove, Cédric Darreau, Nicolas Lerolle, Pierre Asfar, CNER DESC réanimation grand ouest
S101 Corporal Contention at the Onset of Septic shock (COCOONs): study protocol and preliminary results of a phase II trial
Auguste Dargent, Audrey Large, Agnès Soudry-Faure, Sebastien Prin, Pierre-Emmanuel Charles, Jean-Pierre Quenot, COCOONs Study Group
S102 Veno-arterial ECMO for refractory cardiogenic shock following cardiac arrest
Marc Pineton De Chambrun, Nicolas Bréchot, Guillaume Hekimian, Guillaume Lebreton, Matthieu Schmidt, Pierre Demondion, Ania Nieszkowska, Jean Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes, Charles-Edouard Luyt
S103 Outcome of patients with pulmonary embolism treated by extra-corporeal life support (ECLS)
Jean-Christophe Blanchard, François Belon, Sydney Chocron, Nicolas Meneveau, Loïc Barrot, Nicolas Belin, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Gaël Piton, Gilles Capellier
S104 Acute massive pulmonary embolism rescued by veno-arterial extracorporeal membrane oxygenation
Filippo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hékimian, Ania Nieszkowska, Charles-Edouard Luyt, Pascal Leprince, Jean Louis Trouillet, Alain Combes, Matthieu Schmidt
S105 Outcome of patient recused for extracorporeal membrane oxygenation for ARDS
Pierre-Emmanuel Meynieu, Benjamin Repusseau, Virginie Perrier, Arnaud Germain, Antoine Dewitte, Hadrien Roze, Alexandre Ouattara
S106 Refractory electrical storm rescued by venoarterial extracorporeal membrane oxygenation
Guillaume Baudry, Guillaume Lebreton, Guillaume Hekimian, Nicolas Brechot, Ania Nieszkowska, Charles-Edouard Luyt, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Matthieu Schmidt
S107 Incidence and determinants of severe bleeding among patients with extra-corporeal membrane oxygenation (ECMO)
Lucie Hierle, François Belon, Guillaume Besch, Sebastien Pili-Floury, Loïc Barrot, Bérengère Vivet, Guylaine Labro, Jean-Christophe Navellou, Cyrille Patry, Nicolas Belin, Gaël Piton, Gilles Capellier
S108 Venovenous extracorporeal membranous oxygenation device-related infections and colonizations
Guillemette Thomas, Jean-Marie Forel, Nadim Cassir, Sami Hraiech, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian
S109 High emergency lung transplant for end-stage cystic fibrosis: ECMO as a bridge to transplant for patients with temporary contraindications
Grégoire Trebbia, Kiruba Govindaradjou, Alexis Soummer, Jérôme Devaquet, Clément Picard, Antoine Roux, François Parquin, Elise Cuquemelle, Morgan Leguen, Marie-Louise Felten, Edouard Sage, Alain Chapelier, Charles Cerf
S110 Malignant acute respiratory distress syndrome in diffuse lepidic adenocarcinoma (DLA): diagnosis and current issues
Maxens Decavèle, Antoine Parrot, Michael Duruisseaux, Jocelyne Fleury, Martine Antoine, Marie-France Carette, Marie Wislez, Muriel Fartoukh
S111 Acute respiratory failure from pulmonary leukemic infiltrates: diagnosis contribution of high-resolution computed tomography (HRCT)
Claire Givel, Virginie Lemiale, Constance De Margerie-Mellon, Etienne Lengliné, Leïla Mourtada, François Vincent, Akli Chermak, Eric De Kerviler, Elie Azoulay
S112 Characteristics and outcome of patients with interstitial lung disease admitted to the intensive care unit over a 15-year period
Yacine Tandjaoui-Lambiotte, Frédéric Gonzalez, Olivia Freynet, Guillaume Van Der Meersch, Johanna Oziel, Christophe Huang, Philippe Karoubi, Christophe Clec’h, Yves Cohen
S113 Outcome of patients admitted in intensive care unit for acute manifestation of small vessel vasculitis
Antoine Kimmoun, Elisabeth Baux, Vincent Das, Nicolas Terzi, Patrice Talec, Stephan Ehrmann, Guillaume Geri, Steven Grange, Nadia Anguel, Alexandre Demoule, Anne-Sophie Moreau, Elie Azoulay, Jean-Pierre Quenot, Julie Boisramé-Helms, Guillaume Louis, Romain Sonneville, Nicolas Girerd, Bruno Levy
S114 A monocenter retrospective study of predictive factors of prolonged intensive care unit hospitalization after a whole lung lavage procedure for patients with pulmonary alveolar proteinosis
Pauline Tallon, Alice Hadchouel-Duvergé, Nadège Salvi, Pascale Cairet, Jean-Marc Treluyer, Mehdi Oualha, Fabrice Lesage, Laure De Saint Blanquat, Sylvain Renolleau, Christophe Delacourt, Laurent Dupic
S115 Free fatty acids plasma profile during acute chest syndrome in adult patients with sickle cell disease: a pilot study
Blandine Lefebvre Blandine, Guillaume Lefevre, Laurence Beraud, Pierre Mora, Zoé Coppere, Antonin Lamaziere, François Lionnet, Muriel Fartoukh
S116 Extravascular lung water and lung ultrasound to predict severe primary graft dysfunction following lung transplantation
Samuel Lehingue, Christophe Guervilly, Stéphanie Dizier, Laurent Zieleskiewicz, Xavier D’journo, Guillemette Thomas, Fanny Klasen, Mélanie Adda, Antoine Roch, Forel Jean-Marie, Marc Leone, Laurent Papazian
S117 Results of the international multicentric prospective observational study Phase Angle Project: phase angle measured by bioimpedance analysis at intensive care unit (ICU) admission predicts 28-day survival
Ronan Thibault, Anne-Marie Makhlouf, Aurélien Mulliez, Cristina Gonzalez, Sylvain Dadet, Gintautas Kekstas, Jean-Charles Preiser, Kozjek Nada Rotovnik, Isabel Ceniceros Rozalen, Kinga Kupczyk, Zeljko Krznaric, Fabienne Tamion, Noël Cano, Claude Pichard, Phase angle project Investigators
S118 Nutrireaped: a survey of physician nutrition practices and knowledge in French-speaking pediatric intensive care units
Bénédicte Gaillard-Le Roux, Aurelien Jacquot, Corinne Jotterand, Shancy Rooze, Clemence Moullet, Flavie Letois, Frederic Valla
S119 A computerized tool increases compliance to caloric and protein targets and may lower mortality in neutropenic hematologic patients in the ICU: the NUTCHOCO study: NUTritionnal Care in Hematologic Oncologic patients and Critical Outcome
Aurélia Henin, Florence Ettori, Christophe Zemmour, Laurent Chow-Chine, Jeanpaul Brun, Antoine Sannini, Magali Bisbal, Marion Faucher, Jean Marie Boher, Djamel Mokart
S120 Systemic evaluation of intakes in patients receiving noninvasive ventilation: the STARVE study
Michel Arnaout, Aude Marincamp, Matthieu Reffienna, Anne-Sophie Debue, Pierre Lucas, Audrey Feltry, Julien Charpentier, Benoit Champigneulle, Wulfran Bougouin, Guillaume Geri, Frédéric Pène, Jean-Paul Mira, Alain Cariou, Jean-Daniel Chiche, Groupe de travail sur la ventilation
S121 Computerized glucose control in the ICU
Salah Adel Ben, Juliette Audibert, Alexandre Conia, Olivier Gontier, Mouldi Hamrouni, Thierry Lherm, Abdelkader Ouchenir, Jérôme Rétif, Alain Proudhom, Chantal Lagardere, Stéphane Tissot, Pierre Kalfon
S122 Toxicodynetics in mono-intoxications with oxazepam and nordiazepam: an approach to a better understanding of drug–drug interaction
Lynn Sacre, Antoine Villa, Alaywa Khadija, Robert Garnier, Frederic Baud
S123 Rapid triage of victims suspected of a chemical attack: a one-page sheet allowing identifying the toxidrome: the doctors without borders (MSF) experience
Frederic Baud, Robert Garnier, Brigitte Vasset, Annette Heinzelman
S124 Low sensitivity of toxicological analysis in daily practice of acute poisonings: an endless rupture in spite of modern technology
Frederic Baud, Alaywa Khadija, Romain Jouffroy, Lionel Lamhaut
S125 Context of the request and interest of toxicological screening in a medical intensive care unit
Elsa Démarest Durand, Fabienne Tamion, Christophe Girault, Gaetan Beduneau, Dorothée Carpentier, Patricia Compagnon, Steven Grange
S126 Acute poisoning in emergency department
Neila Maaroufi, Dhaouadi Mahassen
S127 Management of poising: Are there differences between specialised and non-specialised emergencies?
A M’rad, Alia Jebri, Youssef Blel, Hend Ben Lakhal, Messaouda Khelfa, Nozha Brahmi, H Thabet
S128 Jusquiame poisoning: report of a family intoxication
Hassen Ben Ghezala, Salah Snouda, Rebeh Daoudi, Moez Kaddour
S129 Morbi-mortality of poisoning episodes in Paris region: a test for a multisource surveillance system
Céline Legout, Robert Garnier, Antoine Villa, Frederic Baud, Philippe Aegerter, Anne Castot-Villepelet
S130 Atypical pneumonia in the ICU: a retrospective multicentric study
Sandrine Valade, Virginie Lemiale, Laurent Argaud, Frédéric Pène, Laurent Papazian, Fabrice Bruneel, Amélie Seguin, Achille Kouatchet, Johanna Oziel, Olivier Lesieur, Florence Boissier, Bruno Megarbane, Naïke Bigé, Noelle Brule, Anne-Sophie Moreau, Alexandre Lautrette, Elie Azoulay
S131 Severe leptospirosis: analysis of mortality and organ failures in 134 patients hospitalized in intensive care unit
Benjamin Delmas, Julien Jabot, Paul Chanareille, Jérôme Allyn, Nicolas Allou, Cyril Ferdynus, Bernard-Alex Gauzere, Olivier Martinet, David Vandroux
S132 In severe pneumonia, respiratory viruses are not passengers but pathogens
Guillaume Voiriot, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Mathilde Neuville, Caroline Morbieu, Charles Burdet, Aguila Radjou, François-Xavier Lescure, Roland Smonig, Laurence Armand-Lefevre, Bruno Mourvillier, Yazdan Yazdanpanah, Jean-François Soubirou, Stephane Ruckly, Nadira Houhou-Fidouh, Jean-François Timsit
S133 Critical care management of patients with HHV8-associated disorders
Marine Cazaux, Claire Pichereau, Marion Venot, Sandrine Valade, Virginie Lemiale, Akli Chermak, Emmanuel Canet, Le Goff Jérôme, Veronique Meignin, David Boutboul, Lionel Galicier, Elie Azoulay, Eric Mariotte
S134 Emerging moulds in critically ill patients: epidemiological trends, clinical features and ICU outcome
Laura Platon, Philippe Rispail, Vincent Brunot, N. Besnard, Patrice Ceballos, Kada Klouche
S135 Intensive care unit-associated bloodstream infection and ventilator-associated pneumonia in critically ill cancer patients: a 12-year retrospective study
Annabelle Stoclin, Federico Rotolo, Muriel Wartelle, Yosr Hicheri, Sylvia Maillet, Elisabeth Chachaty, Jean-Pierre Pignon, François Blot
S136 Is diabetes mellitus a risk factor for intensive care unit-acquired infections?
Marion Venot, Stephane Ruckly, Christophe Clec’h, Michaël Darmon, Bernard Allaouchiche, Dany Goldgran Toledano, Maïté Garrouste-Orgeas, Christophe Adrie, Jean-François Timsit, Elie Azoulay
O85 Short-term physiological effects of nasal high-flow in healthy subjects. Impact of flow rates on the work of breathing
Mathieu Delorme, Pierre Alexandre Bouchard, Mathieu Simon, François Lellouche
O86 High-flow therapy allows a decreased workload of accessory respiratory muscles
Emilie Bialais, Dupuis Julie, Laura Paoloni, Gregory Reychler, Xavier Wittebolle
O87 Patient perception and feasibility of early mobilization in the critically ill
Cheryl Hickmann, Diego Castanares-Zapatero, Emilie Bialais, Jonathan Dugernier, Antoine Tordeur, Lise Colmant, Xavier Wittebole, Giuseppe Tirone, Jean Roeseler, Pierre-François Laterre
P252 Early rehabilitation in critically ill patients: a prospective multicenter assessment of real-life practice
Lorraine Ducroux, Sylvie L’hotellier, Elodie Baumgarten, Stéphanie Borschneck, Francis Schneider, Vincent Castelain
P253 Motor imagery and functional magnetic resonance imaging
Claire Kemlin, Eric Moulton, Charlotte Rosso
P254 Thoracic ultrasound: potential new tool for physiotherapists in respiratory management—a narrative review
Aymeric Le Neindre, Silvia Mongodi, Francois Philippart, Béaïd Bouhemad
P255 In vitro comparison of a vibrating-mesh nebulizer operating in expiratory synchronized and inspiratory nebulization modes during noninvasive ventilation
Joana Rodrigues, Caroline Botteau, Jonathan Dugernier, Giuseppe Liistro, Gregory Reychler, Jean-Bernard Michotte
P256 Evaluation of a new system of oxygen administration: the Wenoll system
Frédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Frank Vantrimpont, Sharam Machayeckhi
P257 Evaluation of three portable oxyconcentrators in high altitude
Frédéric Duprez, François Waroquier, Karel Christiaens, Grégory Cuvelier, Charbel Elkhawand, Frank Vantrimpont, Sharam Machayeckhi, Frank Vermeesh
PMCID: PMC4912513  PMID: 27316915
7.  The Predictive Value of the NICE “Red Traffic Lights” in Acutely Ill Children 
PLoS ONE  2014;9(3):e90847.
Early recognition and treatment of febrile children with serious infections (SI) improves prognosis, however, early detection can be difficult. We aimed to validate the predictive rule-in value of the National Institute for Health and Clinical Excellence (NICE) most severe alarming signs or symptoms to identify SI in children.
Design, Setting and Participants
The 16 most severe (“red”) features of the NICE traffic light system were validated in seven different primary care and emergency department settings, including 6,260 children presenting with acute illness.
Main Outcome Measures
We focussed on the individual predictive value of single red features for SI and their combinations. Results were presented as positive likelihood ratios, sensitivities and specificities. We categorised “general” and “disease-specific” red features. Changes in pre-test probability versus post-test probability for SI were visualised in Fagan nomograms.
Almost all red features had rule-in value for SI, but only four individual red features substantially raised the probability of SI in more than one dataset: “does not wake/stay awake”, “reduced skin turgor”, “non-blanching rash”, and “focal neurological signs”. The presence of ≥3 red features improved prediction of SI but still lacked strong rule-in value as likelihood ratios were below 5.
The rule-in value of the most severe alarming signs or symptoms of the NICE traffic light system for identifying children with SI was limited, even when multiple red features were present. Our study highlights the importance of assessing the predictive value of alarming signs in clinical guidelines prior to widespread implementation in routine practice.
PMCID: PMC3954615  PMID: 24633015
8.  Risk score to stratify children with suspected serious bacterial infection: observational cohort study 
Archives of Disease in Childhood  2011;96(4):361-367.
To derive and validate a clinical score to risk stratify children presenting with acute infection.
Study design and participants
Observational cohort study of children presenting with suspected infection to an emergency department in England. Detailed data were collected prospectively on presenting clinical features, laboratory investigations and outcome. Clinical predictors of serious bacterial infection (SBI) were explored in multivariate logistic regression models using part of the dataset, each model was then validated in an independent part of the dataset, and the best model was chosen for derivation of a clinical risk score for SBI. The ability of this score to risk stratify children with SBI was then assessed in the entire dataset.
Main outcome measure
Final diagnosis of SBI according to criteria defined by the Royal College of Paediatrics and Child Health working group on Recognising Acute Illness in Children.
Data from 1951 children were analysed. 74 (3.8%) had SBI. The sensitivity of individual clinical signs was poor, although some were highly specific for SBI. A score was derived with reasonable ability to discriminate SBI (area under the receiver operator characteristics curve 0.77, 95% CI 0.71 to 0.83) and risk stratify children with suspected SBI.
This study demonstrates the potential utility of a clinical score in risk stratifying children with suspected SBI. Further work should aim to validate the score and its impact on clinical decision making in different settings, and ideally incorporate it into a broader management algorithm including additional investigations to further stratify a child's risk.
PMCID: PMC3158666  PMID: 21266341

Results 1-8 (8)