AAPS J Volume 14(3); September 2012

Volume 14(3); September 2012

Editorial

Ligand Binding Assays in the 21^st Century Laboratory—A Call for Change

Chad A. Ray, Ago B. Ahene

AAPS J. 2012 September; 14(3): 377–379. Published online 2012 April 3. doi: 10.1208/s12248-012-9351-8

PMCID:: PMC3385813

Full Text PDF–100K

Review Articles

Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives

Ye Sun, Lei Zhu, Tian Wu, Ting Cai, Erica M. Gunn, Lian Yu

AAPS J. 2012 September; 14(3): 380–388. Published online 2012 March 21. doi: 10.1208/s12248-012-9345-6

PMCID:: PMC3385820

Abstract Full Text PDF–489K

Tissue Distribution Studies of Protein Therapeutics Using Molecular Probes: Molecular Imaging

Simon-Peter Williams

AAPS J. 2012 September; 14(3): 389–399. Published online 2012 March 31. doi: 10.1208/s12248-012-9348-3

PMCID:: PMC3385809

Abstract Full Text PDF–562K

What about Pain in Disorders of Consciousness?

C. Schnakers, C. Chatelle, A. Demertzi, S. Majerus, S. Laureys

AAPS J. 2012 September; 14(3): 437–444. Published online 2012 April 18. doi: 10.1208/s12248-012-9346-5

PMCID:: PMC3385819

Abstract Full Text PDF–255K

Pain Assessment in Human Fetus and Infants

Carlo Valerio Bellieni

AAPS J. 2012 September; 14(3): 456–461. Published online 2012 April 18. doi: 10.1208/s12248-012-9354-5

PMCID:: PMC3385812

Abstract Full Text PDF–184K

Paradigm Shift in Toxicity Testing and Modeling

Hongmao Sun, Menghang Xia, Christopher P. Austin, Ruili Huang

AAPS J. 2012 September; 14(3): 473–480. Published online 2012 April 20. doi: 10.1208/s12248-012-9358-1

PMCID:: PMC3385826

Abstract Full Text PDF–334K

Research Articles

Effects of Device and Formulation on In Vitro Performance of Dry Powder Inhalers

Wallace P. Adams, Sau L. Lee, Robert Plourde, Robert A. Lionberger, Craig M. Bertha, William H. Doub, Jean-Marc Bovet, Anthony J. Hickey

AAPS J. 2012 September; 14(3): 400–409. Published online 2012 April 5. doi: 10.1208/s12248-012-9352-7

PMCID:: PMC3385814

Abstract Full Text PDF–430K

Performance Comparison of Various Maximum Likelihood Nonlinear Mixed-Effects Estimation Methods for Dose–Response Models

Elodie L. Plan, Alan Maloney, France Mentré, Mats O. Karlsson, Julie Bertrand

AAPS J. 2012 September; 14(3): 420–432. Published online 2012 April 14. doi: 10.1208/s12248-012-9349-2

PMCID:: PMC3385815

Abstract Full Text PDF–938K Supplementary Material

A Technique to Estimate In Vivo Dissolution Profiles Without Data from a Solution

Jack A. Cook

AAPS J. 2012 September; 14(3): 433–436. Published online 2012 April 14. doi: 10.1208/s12248-012-9355-4

PMCID:: PMC3385817

Abstract Full Text PDF–238K

Pharmacokinetic mAb–mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

Lubna Abuqayyas, Joseph P. Balthasar

AAPS J. 2012 September; 14(3): 445–455. Published online 2012 April 18. doi: 10.1208/s12248-012-9357-2

PMCID:: PMC3385816

Abstract Full Text PDF–519K

Toward Global Standards for Comparator Pharmaceutical Products: Case Studies of Amoxicillin, Metronidazole, and Zidovudine in the Americas

Raimar Löbenberg, Nadia B. Chacra, Erika S. Stippler, Vinod P. Shah, Anthony J. DeStefano, Walter W. Hauck, Roger L. Williams

AAPS J. 2012 September; 14(3): 462–472. Published online 2012 April 19. doi: 10.1208/s12248-012-9350-9

PMCID:: PMC3385829

Abstract Full Text PDF–638K Supplementary Material

Effects of Molecular Weight and Loading on Matrix Metalloproteinase-2 Mediated Release from Poly(Ethylene Glycol) Diacrylate Hydrogels

Amy E. Ross, Mary Y. Tang, Richard A. Gemeinhart

AAPS J. 2012 September; 14(3): 482–490. Published online 2012 April 26. doi: 10.1208/s12248-012-9356-3

PMCID:: PMC3385811

Abstract Full Text PDF–416K

In vitro–In Vivo Correlations: Tricks and Traps

J.-M. Cardot, B. M. Davit

AAPS J. 2012 September; 14(3): 491–499. Published online 2012 May 1. doi: 10.1208/s12248-012-9359-0

PMCID:: PMC3385821

Abstract Full Text PDF–440K

Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms

Stacey D. Finley, Aleksander S. Popel

AAPS J. 2012 September; 14(3): 500–509. Published online 2012 May 1. doi: 10.1208/s12248-012-9363-4

PMCID:: PMC3385824

Abstract Full Text PDF–665K Supplementary Material

Development and Advanced Validation of an Optimized Method for the Quantitation of Aβ₄₂ in Human Cerebrospinal Fluid

Valerie C. Cullen, Ross A. Fredenburg, Cindy Evans, Phyllis R. Conliffe, Michael E. Solomon

AAPS J. 2012 September; 14(3): 510–518. Published online 2012 May 3. doi: 10.1208/s12248-012-9360-7

PMCID:: PMC3385823

Abstract Full Text PDF–315K Supplementary Material

A Platform for Characterizing Therapeutic Monoclonal Antibody Breakdown Products by 2D Chromatography and Top-Down Mass Spectrometry

Matthew T. Mazur, Richard S. Seipert, David Mahon, Qinwei Zhou, Tun Liu

AAPS J. 2012 September; 14(3): 530–541. Published online 2012 May 12. doi: 10.1208/s12248-012-9361-6

PMCID:: PMC3385834

Abstract Full Text PDF–1.6M Supplementary Material

Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

Joost Westerhout, Bart Ploeger, Jean Smeets, Meindert Danhof, Elizabeth C. M. de Lange

AAPS J. 2012 September; 14(3): 543–553. Published online 2012 May 17. doi: 10.1208/s12248-012-9366-1

PMCID:: PMC3385827

Abstract Full Text PDF–392K

Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses

Ron J. Keizer, Anthe S. Zandvliet, Jos H. Beijnen, Jan H. M. Schellens, Alwin D. R. Huitema

AAPS J. 2012 September; 14(3): 601–611. Published online 2012 May 31. doi: 10.1208/s12248-012-9373-2

PMCID:: PMC3385822

Abstract Full Text PDF–665K Supplementary Material

Mini-Review

ADME of Biologics—What Have We Learned from Small Molecules?

Thomayant Prueksaritanont, Cuyue Tang

AAPS J. 2012 September; 14(3): 410–419. Published online 2012 April 7. doi: 10.1208/s12248-012-9353-6

PMCID:: PMC3385832

Abstract Full Text PDF–366K

Announcement

Fish Drug Analysis—Phish-Pharm: 2011 Update

Renate Reimschuessel

AAPS J. 2012 September; 14(3): 481. Published online 2012 April 25. doi: 10.1208/s12248-012-9362-5

PMCID:: PMC3385818

Full Text PDF–95K

Brief/Technical Note

Biopharmaceutic Planning in Pediatric Drug Development

Vivek S. Purohit

AAPS J. 2012 September; 14(3): 519–522. Published online 2012 May 5. doi: 10.1208/s12248-012-9364-3

PMCID:: PMC3385835

Abstract Full Text PDF–250K

White Paper

Nonclinical Dose Formulation: Out of Specification Investigations

Troy Appleton, Peter Bryan, Denise Contos, Teresa R. Henry, Paul Lehmann, Susan Ohorodnik, Dave Reed, Chantal Robichaud, John Schetter, Natalie South, John Weissmann, Monica Lee Whitmire

AAPS J. 2012 September; 14(3): 523–529. Published online 2012 May 8. doi: 10.1208/s12248-012-9347-4

PMCID:: PMC3385838

Abstract Full Text PDF–152K

Retraction Note

Erratum to: Recent advances for the treatment of cocaine abuse: central nervous system immunopharmacotherapy

Tobin J. Dickerson, Kim D. Janda

AAPS J. 2012 September; 14(3): 542. Published online 2012 May 15. doi: 10.1208/s12248-012-9365-2

Retracts:: AAPS J. 2005 September; 7(3): E579–E586.

PMCID:: PMC3385836

Retraction PDF–89K Retracted Article

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