AAPS J Volume 14(2); June 2012

Volume 14(2); June 2012

Research Articles

A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model

Emilie Hénin, Martin Bergstrand, Joseph F. Standing, Mats O. Karlsson

AAPS J. 2012 June; 14(2): 155–163. Published online 2012 January 28. doi: 10.1208/s12248-012-9324-y

PMCID:: PMC3326175

Abstract Full Text PDF–470K Supplementary Material

Population Analyses of Efficacy and Safety of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain

Sandeep Dutta, Balakrishna S. Hosmane, Walid M. Awni

AAPS J. 2012 June; 14(2): 168–175. Published online 2012 February 11. doi: 10.1208/s12248-012-9328-7

PMCID:: PMC3326158

Abstract Full Text PDF–312K

Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models

Camille Vong, Martin Bergstrand, Joakim Nyberg, Mats O. Karlsson

AAPS J. 2012 June; 14(2): 176–186. Published online 2012 February 17. doi: 10.1208/s12248-012-9327-8

PMCID:: PMC3326172

Abstract Full Text PDF–602K

Cutaneous Microdialysis: Cytokine Evidence for Altered Innate Reactivity in the Skin of Psoriasis Patients?

Florence Sjögren, Karin Davidsson, Michael Sjöström, Chris D. Anderson

AAPS J. 2012 June; 14(2): 187–195. Published online 2012 February 29. doi: 10.1208/s12248-012-9331-z

PMCID:: PMC3326164

Abstract Full Text PDF–531K Supplementary Material

Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting

Caroline Watson, Joshua S. Sharp

AAPS J. 2012 June; 14(2): 206–217. Published online 2012 March 2. doi: 10.1208/s12248-012-9336-7

PMCID:: PMC3326162

Abstract Full Text PDF–574K Supplementary Material

Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits

Yanjun Zhao, Marc B. Brown, Rajeshree H. Khengar, Matthew J. Traynor, Pedro Barata, Stuart A. Jones

AAPS J. 2012 June; 14(2): 218–224. Published online 2012 March 1. doi: 10.1208/s12248-012-9325-x

PMCID:: PMC3326174

Abstract Full Text PDF–145K

Design and Characterization of Novel Peptide-Coated Lipid Nanoparticles for Targeting Anti-HIV Drug to CD4 Expressing Cells

Aaron N. Endsley, Rodney J. Y. Ho

AAPS J. 2012 June; 14(2): 225–235. Published online 2012 March 6. doi: 10.1208/s12248-012-9329-6

PMCID:: PMC3326167

Abstract Full Text PDF–355K

Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions

Thomas M. Scherer, Stephenie Leung, Laura Owyang, Steven J. Shire

AAPS J. 2012 June; 14(2): 236–243. Published online 2012 March 6. doi: 10.1208/s12248-012-9335-8

PMCID:: PMC3326173

Abstract Full Text PDF–408K Supplementary Material

The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

Arik Dahan, Jonathan M. Miller

AAPS J. 2012 June; 14(2): 244–251. Published online 2012 March 6. doi: 10.1208/s12248-012-9337-6

PMCID:: PMC3326160

Abstract Full Text PDF–396K

Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice

Fang Wu, Mitalee Tamhane, Marilyn E. Morris

AAPS J. 2012 June; 14(2): 252–261. Published online 2012 March 6. doi: 10.1208/s12248-012-9342-9

PMCID:: PMC3326166

Abstract Full Text PDF–323K Supplementary Material

Role of Metabolism in the Effects of Genistein and Its Phase II Conjugates on the Growth of Human Breast Cell Lines

Bo Yuan, Linglan Wang, Yi Jin, Huijuan Zhen, Pingwei Xu, Youjun Xu, Chibing Li, Haiyan Xu

AAPS J. 2012 June; 14(2): 329–344. Published online 2012 March 14. doi: 10.1208/s12248-012-9338-5

PMCID:: PMC3326171

Abstract Full Text PDF–1.0M

Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters

Min Zhang, Jin Yang, Lei Tao, Lingjun Li, Pengcheng Ma, John Paul Fawcett

AAPS J. 2012 June; 14(2): 345–351. Published online 2012 March 15. doi: 10.1208/s12248-012-9341-x

PMCID:: PMC3326157

Abstract Full Text PDF–183K

A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding

Guohua An, Marilyn E. Morris

AAPS J. 2012 June; 14(2): 352–364. Published online 2012 March 27. doi: 10.1208/s12248-012-9344-7

PMCID:: PMC3326165

Abstract Full Text PDF–559K

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT_1A Partial Agonist

Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbell

AAPS J. 2012 June; 14(2): 365–376. Published online 2012 March 28. doi: 10.1208/s12248-012-9343-8

PMCID:: PMC3326163

Abstract Full Text PDF–670K Supplementary Material

Commentary

Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory

Leslie Z. Benet

AAPS J. 2012 June; 14(2): 164–167. Published online 2012 February 3. doi: 10.1208/s12248-012-9326-9

PMCID:: PMC3326156

Full Text PDF–96K

Research Paper

An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs

Paul A. Dickinson, Ragheb Abu Rmaileh, Lee Ashworth, Richard A. Barker, Wendy M. Burke, Claire M. Patterson, Nick Stainforth, Mohammed Yasin

AAPS J. 2012 June; 14(2): 196–205. Published online 2012 February 29. doi: 10.1208/s12248-012-9333-x

PMCID:: PMC3326170

Abstract Full Text PDF–494K

Review Articles

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu, Duxin Sun

AAPS J. 2012 June; 14(2): 262–281. Published online 2012 March 10. doi: 10.1208/s12248-012-9332-y

PMCID:: PMC3326168

Abstract Full Text PDF–442K

Challenges in Development of Nanoparticle-Based Therapeutics

Neil Desai

AAPS J. 2012 June; 14(2): 282–295. Published online 2012 March 10. doi: 10.1208/s12248-012-9339-4

PMCID:: PMC3326161

Abstract Full Text PDF–466K

Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

Narendra Chirmule, Vibha Jawa, Bernd Meibohm

AAPS J. 2012 June; 14(2): 296–302. Published online 2012 March 10. doi: 10.1208/s12248-012-9340-y

PMCID:: PMC3326159

Abstract Full Text PDF–187K

Challenges in Development of Targeted Liposomal Therapeutics

Rupa R. Sawant, Vladimir P. Torchilin

AAPS J. 2012 June; 14(2): 303–315. Published online 2012 March 14. doi: 10.1208/s12248-012-9330-0

PMCID:: PMC3326155

Abstract Full Text PDF–393K

White Paper

Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents

Denise M. O’Hara, Valerie Theobald, Adrienne Clements Egan, Joel Usansky, Murli Krishna, Julie TerWee, Mauricio Maia, Frank P. Spriggs, John Kenney, Afshin Safavi, Jeannine Keefe

AAPS J. 2012 June; 14(2): 316–328. Published online 2012 March 14. doi: 10.1208/s12248-012-9334-9

PMCID:: PMC3326169

Abstract Full Text PDF–581K Supplementary Material

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American Association of Pharmaceutical Scientists

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