This journal provides early access to some articles.
Volume 68(Pt 2); February 1, 2012
Christina A. Kirby, Atwood Cheung, Aleem Fazal, Michael D. Shultz, Travis Stams
Crystal structures of human tankyrase I in complex with small-molecule inhibitors PJ34 and XAV939 have been determined, both to 2.0 Å. The TNKS1-PJ34 system allows for displacement soaking and, therefore, is an ideal system for structure-based drug design.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 February 1; 68(Pt 2): 115–118. Published online 2012 January 21. doi: 10.1107/S1744309111051219
Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures
Raji E. Joseph, Nathaniel D. Ginder, Julie A. Hoy, Jay C. Nix, D. Bruce Fulton, Richard B. Honzatko, Amy H. Andreotti
The interleukin-2 tyrosine kinase Src homology 2 domain was crystallized and its structure was solved to 2.35 Å resolution. The structure reveals a domain-swapped dimer that is related to other dimeric SH2 domains solved previously. The cis–trans-prolyl isomerization that is evident from solution studies of Itk SH2 cannot be observed in the crystal structure.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 February 1; 68(Pt 2): 145–153. Published online 2012 January 25. doi: 10.1107/S1744309111049761
Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas aeruginosa PelD
Lindsey S. Marmont, John C. Whitney, Howard Robinson, Kelly M. Colvin, Matthew R. Parsek, P. Lynne Howell
The expression, purification and crystallization of a soluble construct of the putative inner membrane protein PelD from P. aeruginosa is described. The crystals diffracted to a resolution of 2.2 Å.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 February 1; 68(Pt 2): 181–184. Published online 2012 January 26. doi: 10.1107/S1744309111052109
International Union of Crystallography
IUCr Editorial Office
Notes for authors.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 February 1; 68(Pt 2): 247–251. Published online 2012 January 28. doi: 10.1107/S1744309111042448