Breast Cancer Res Volume 12(Suppl 1); 2010

Volume 12(Suppl 1); 2010

Lecture Presentation

Tissue banking

WF Symmans

Breast Cancer Res. 2010; 12(Suppl 1): L1. Published online 2010 May 18. doi: 10.1186/bcr2489

PMCID:: PMC2875554

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Biomarkers for the diagnosis and prediction of therapeutic response in clinical breast cancer

J Bartlett

Breast Cancer Res. 2010; 12(Suppl 1): L2. Published online 2010 May 18. doi: 10.1186/bcr2490

PMCID:: PMC2875555

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Recent advances in treatment of metastatic breast cancer

R Coleman

Breast Cancer Res. 2010; 12(Suppl 1): L3. Published online 2010 May 18. doi: 10.1186/bcr2491

PMCID:: PMC2875556

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Oral Presentation

Male versus female breast cancer: a comparative study of 523 matched cases reveals differences behind similarity

V Speirs, G Ball, Male Breast Cancer Consortium

Breast Cancer Res. 2010; 12(Suppl 1): O1. Published online 2010 May 18. doi: 10.1186/bcr2492

PMCID:: PMC2875557

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Upregulation of ADAM proteases and HER ligands through a feedback loop mediates acquired resistance to trastuzumab in HER2-amplified breast cancer

M Gijsen, P King, T Perera, P Parker, B Larijani, A Harris, A Kong

Breast Cancer Res. 2010; 12(Suppl 1): O2. Published online 2010 May 18. doi: 10.1186/bcr2493

PMCID:: PMC2875558

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New regulators of the BRCA1 response to genotoxic stress

JR Morris, C Boutell, M Keppler, R Densham, D Weekes, A Alamshah, L Butler, Y Galanty, L Pangon, T Kiuchi, T Ng, E Solomon

Breast Cancer Res. 2010; 12(Suppl 1): O3. Published online 2010 May 18. doi: 10.1186/bcr2494

PMCID:: PMC2875559

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DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

JM Flanagan, S Kugler, N Waddell, CN Johnstone, A Marsh, S Henderson, P Simpson, L da Silva, K Khanna, S Lakhani, C Boshoff, G Chenevix-Trench

Breast Cancer Res. 2010; 12(Suppl 1): O4. Published online 2010 May 18. doi: 10.1186/bcr2495

PMCID:: PMC2875560

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Differentiation therapy: targeting breast cancer stem cells to reduce resistance to radiotherapy and chemotherapy

R Roy, PM Willan, R Clarke, G Farnie

Breast Cancer Res. 2010; 12(Suppl 1): O5. Published online 2010 May 18. doi: 10.1186/bcr2496

PMCID:: PMC2875561

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Transforming growth factor-beta co-receptor endoglin suppresses breast cancer invasion and metastasis

LA Henry, DJ Johnson, S Lee, PR Quinlan, T Crook, AM Thompson, JS Reis-Filho, CM Isacke

Breast Cancer Res. 2010; 12(Suppl 1): O6. Published online 2010 May 18. doi: 10.1186/bcr2497

PMCID:: PMC2875562

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Poster Presentation

Activin B functions downstream of BRCA1 in stem cell maintenance

MM Murray, N Buckley, DP Harkin

Breast Cancer Res. 2010; 12(Suppl 1): P1. Published online 2010 May 18. doi: 10.1186/bcr2498

PMCID:: PMC2875563

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FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance

J Millour, EW Lam

Breast Cancer Res. 2010; 12(Suppl 1): P2. Published online 2010 May 18. doi: 10.1186/bcr2499

PMCID:: PMC2875564

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A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth

C Raimondi, T Maffucci, BVL Potter, M Falasca

Breast Cancer Res. 2010; 12(Suppl 1): P3. Published online 2010 May 18. doi: 10.1186/bcr2500

PMCID:: PMC2875565

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Regulation of mammary epithelial architecture by PTEN

JC Lim, L Davidson, NR Weerasinghe, G Zilidis, P Tibarewal, L Spinelli, NR Leslie

Breast Cancer Res. 2010; 12(Suppl 1): P4. Published online 2010 May 18. doi: 10.1186/bcr2501

PMCID:: PMC2875566

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Genetic analysis of lobular carcinoma in situ and associated invasive lobular cancer

LR Yates, A Jones, H Patel, A Mackay, C Gillett, S Pinder, I Tomlinson, R Roylance, EJ Sawyer

Breast Cancer Res. 2010; 12(Suppl 1): P5. Published online 2010 May 18. doi: 10.1186/bcr2502

PMCID:: PMC2875567

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Suppression of the NF-κB co-factor, Bcl3, delays the metastatic progression of breast cancer

AM Wakefield, RWE Clarkson

Breast Cancer Res. 2010; 12(Suppl 1): P6. Published online 2010 May 18. doi: 10.1186/bcr2503

PMCID:: PMC2875568

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Identification of signalling pathways downstream of BRCA1 and p63

N Crawford, N Buckley, C Nic An tSaoir, D Tkocz, Z D'Costa, L Oram, P Mullan

Breast Cancer Res. 2010; 12(Suppl 1): P7. Published online 2010 May 18. doi: 10.1186/bcr2504

PMCID:: PMC2875569

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D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest

M Aoubala, F Murray-Zmijewski, M Khoury, S Perrier, K Fernandes, AC Prats, D Lane, JC Bourdon

Breast Cancer Res. 2010; 12(Suppl 1): P8. Published online 2010 May 18. doi: 10.1186/bcr2505

PMCID:: PMC2875570

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Loss of CSMD1 disrupts mammary epithelial morphogenesis

M Kamal, AM Shaaban, DL Holliday, C Toomes, V Speirs, SM Bell

Breast Cancer Res. 2010; 12(Suppl 1): P9. Published online 2010 May 18. doi: 10.1186/bcr2506

PMCID:: PMC2875571

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Phosphoinositide 3-kinase class II beta is a novel target in breast cancer therapy

J Abbott, R Pineiro, MA Oliviero, R Lattanzio, M Piantelli, A Bilancio, T Maffucci, M Falasca

Breast Cancer Res. 2010; 12(Suppl 1): P10. Published online 2010 May 18. doi: 10.1186/bcr2507

PMCID:: PMC2875572

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MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer

HH Alnakhle, PA Burns, M Cummings, AM Hanby, TA Hughes, S Satheesha, AM Shaaban, L Smith, V Speirs

Breast Cancer Res. 2010; 12(Suppl 1): P11. Published online 2010 May 18. doi: 10.1186/bcr2508

PMCID:: PMC2875573

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Regulation of the apoptotic genes in breast cancer cells by the transcription factor CTCF

CF Mendez-Catala, A Vostrov, E Pugacheva, Y Ito, F Docquier, I Chernukhin, D Farrar, G-X Kita, A Murrell, V Lobanankov, E Klenova

Breast Cancer Res. 2010; 12(Suppl 1): P12. Published online 2010 May 18. doi: 10.1186/bcr2509

PMCID:: PMC2875574

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Fulvestrant-induced expression of erbB3 and erbB4 sensitizes ER-positive breast cancer cells to heregulins

IR Hutcheson, L Goddard, JMW Gee, D Barrow, RI Nicholson

Breast Cancer Res. 2010; 12(Suppl 1): P13. Published online 2010 May 18. doi: 10.1186/bcr2510

PMCID:: PMC2875575

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Risks of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

M Ahmed, F Lalloo, A Howell, DG Evans

Breast Cancer Res. 2010; 12(Suppl 1): P14. Published online 2010 May 18. doi: 10.1186/bcr2511

PMCID:: PMC2875576

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ADAMTS15 metalloproteinase inhibits breast cancer cell migration

L Wagstaff, R Kelwick, J Decock, H Arnold, C Pennington, D Jaworski, D Edwards

Breast Cancer Res. 2010; 12(Suppl 1): P15. Published online 2010 May 18. doi: 10.1186/bcr2512

PMCID:: PMC2875577

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Macrophage-mediated breast cancer cell chemotaxis: the role of sphingosine kinase-1 activation

J Nunes, L Sauer, J Turner, J Waxman, J Sturge, D Pshezhetskiy

Breast Cancer Res. 2010; 12(Suppl 1): P16. Published online 2010 May 18. doi: 10.1186/bcr2513

PMCID:: PMC2875578

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PLU-1/Jarid1B contributes to estrogen-induced cell proliferation in the normal mammary gland and in breast cancer, and is required for embryonic survival

S Catchpole, B Spencer-Dene, D Hall, A Scibetta, J Burchell, J Taylor-Papadimitriou

Breast Cancer Res. 2010; 12(Suppl 1): P17. Published online 2010 May 18. doi: 10.1186/bcr2514

PMCID:: PMC2875579

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C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells

CN Birts, JP Blaydes

Breast Cancer Res. 2010; 12(Suppl 1): P18. Published online 2010 May 18. doi: 10.1186/bcr2515

PMCID:: PMC2875580

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RhoBTB2 in breast cancer

CM McKinnon, H Mellor

Breast Cancer Res. 2010; 12(Suppl 1): P19. Published online 2010 May 18. doi: 10.1186/bcr2516

PMCID:: PMC2875581

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Transcriptional regulation of cyclin-dependent kinase inhibitor 1A (P21) by the transcription factor AP-2γ

AG Scibetta, M Canosa, HC Hurst

Breast Cancer Res. 2010; 12(Suppl 1): P20. Published online 2010 May 18. doi: 10.1186/bcr2517

PMCID:: PMC2875582

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Developmental protein HOXC11 cooperates with SRC-1 in breast cancer: an adaptive response to endocrine therapy

M McIlroy, D McCartan, S Early, S Pennington, P O'Gaora, A Hill, L Young

Breast Cancer Res. 2010; 12(Suppl 1): P21. Published online 2010 May 18. doi: 10.1186/bcr2518

PMCID:: PMC2875583

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Insulin-like growth factor binding protein-2 alters the sensitivity of breast cancer cells to chemotherapy

EJ Foulstone, JM Holly, L Zeng, ZE Winters, CM Perks

Breast Cancer Res. 2010; 12(Suppl 1): P22. Published online 2010 May 18. doi: 10.1186/bcr2519

PMCID:: PMC2875584

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Clinicopathologic and molecular predictors of axillary lymph node metastasis in early-stage breast cancer: a mathematical predictive model

MA Aleskandarany, AR Green, EA Rakha, SE Elsheikh, DG Powe, EC Paish, IO Ellis

Breast Cancer Res. 2010; 12(Suppl 1): P23. Published online 2010 May 18. doi: 10.1186/bcr2520

PMCID:: PMC2875585

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Assessing the functional role of caspase-8 gene variants in breast cancer

SH Rigas, M Parry, MW Reed, N Camp, A Cox

Breast Cancer Res. 2010; 12(Suppl 1): P24. Published online 2010 May 18. doi: 10.1186/bcr2521

PMCID:: PMC2875586

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Polymorphisms, endogenous hormone levels and familial breast cancer risk in premenopausal women

K Walker, O Fletcher, N Johnson, C Palles, E Folkerd, SG Hillier, S Moss, L Gibson, M Dowsett, J Peto, I dos santos Silva

Breast Cancer Res. 2010; 12(Suppl 1): P25. Published online 2010 May 18. doi: 10.1186/bcr2522

PMCID:: PMC2875587

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A randomised controlled trial of the psychoneuroimmunological effects of reflexology in women with early-stage breast cancer

DM Sharp, MB Walker, A Chaturvedi, S Upadhyay, A Hamid, AA Walker, J Bateman, F Braid, K Ellwood, C Hebblewhite, T Hope, M Lines, LG Walker

Breast Cancer Res. 2010; 12(Suppl 1): P26. Published online 2010 May 18. doi: 10.1186/bcr2523

PMCID:: PMC2875588

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An integrated informatics platform to facilitate transforming tissue into knowledge

PR Quinlan, A Ashfield, L Jordan, C Purdie, AM Thompson

Breast Cancer Res. 2010; 12(Suppl 1): P27. Published online 2010 May 18. doi: 10.1186/bcr2524

PMCID:: PMC2875589

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Effect of intermittent versus continuous energy restriction on weight loss and breast cancer risk biomarkers

M Harvie, M Pegington, J Cuzick, J Frystyk, A Flyvbjerg, S Jebb, M Mattson, A Howell

Breast Cancer Res. 2010; 12(Suppl 1): P28. Published online 2010 May 18. doi: 10.1186/bcr2525

PMCID:: PMC2875590

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Thioredoxin and related redox systems as targets in breast cancer

CM Woolston, L Zhang, H Evans, A Al-Attar, M Shehata, G Balls, SY Chan, SG Martin

Breast Cancer Res. 2010; 12(Suppl 1): P29. Published online 2010 May 18. doi: 10.1186/bcr2526

PMCID:: PMC2875591

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Could side population cells be an indicator of progression to hormone nonresponsive breast cancer

KM Britton, IJ Harvey, K Stemke-Hale, TWJ Lennard, AP Meeson

Breast Cancer Res. 2010; 12(Suppl 1): P30. Published online 2010 May 18. doi: 10.1186/bcr2527

PMCID:: PMC2875592

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A novel tumour-based test to identify breast cancer due to BRCA1 and BRCA2 mutations

Q An, L Jones, W Tapper, C Chelala, M Iravani, A MacKay, V Hammond, L Durcan, S Gerty, A Ferguson, J Strefford, S Peock, J Reis-Filho, D Easton, A Ashworth, D Eccles

Breast Cancer Res. 2010; 12(Suppl 1): P31. Published online 2010 May 18. doi: 10.1186/bcr2528

PMCID:: PMC2875593

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Melanoma-associated antigen family protein-D4: clinical significance and functional relevance in breast cancer

S Germano, S Rani, S Kennedy, J Crown, M Clynes, L O'Driscoll

Breast Cancer Res. 2010; 12(Suppl 1): P32. Published online 2010 May 18. doi: 10.1186/bcr2529

PMCID:: PMC2875594

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Identification of molecular subtypes within a formalin-fixed, paraffin-embedded breast cancer tumour cohort

JM Mulligan, F McDyer, S Deharo, V Farztdinov, I Halfpenny, T Delaney, F Couch, JE Quinn, P Harkin, R Kennedy

Breast Cancer Res. 2010; 12(Suppl 1): P33. Published online 2010 May 18. doi: 10.1186/bcr2530

PMCID:: PMC2875595

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Evaluating gene expression in formalin-fixed, paraffin-embedded breast cancer tissues using DASL^®

T Burr, R Dixon, A Green, I Ellis, C Murray

Breast Cancer Res. 2010; 12(Suppl 1): P34. Published online 2010 May 18. doi: 10.1186/bcr2531

PMCID:: PMC2875596

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miR-433 overexpression attenuates the spindle assembly checkpoint response to paclitaxel

F Furlong, M Prencipe, A McGoldrick, P McGettigan, D Carney, E Doyle, E Kay, A McCann

Breast Cancer Res. 2010; 12(Suppl 1): P35. Published online 2010 May 18. doi: 10.1186/bcr2532

PMCID:: PMC2875597

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Breast calcification: the 'Cinderella' breast element?

KD Rogers, R Baker, N Stone

Breast Cancer Res. 2010; 12(Suppl 1): P36. Published online 2010 May 18. doi: 10.1186/bcr2533

PMCID:: PMC2875598

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Expression of migration stimulating factor in breast tissues and its clinical significance

AM Schor, S Perrier, AM Woolston, SJ Jones, IR Ellis, MR Islam, S Kazmi, C Purdie, AM Thompson, SL Schor

Breast Cancer Res. 2010; 12(Suppl 1): P37. Published online 2010 May 18. doi: 10.1186/bcr2534

PMCID:: PMC2875599

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Lack of correlation between markers of breast cancer initiating cells

Y Liu, PJ Coates, R Nenutil, MVCL Appleyard, K Murray, AM Thompson

Breast Cancer Res. 2010; 12(Suppl 1): P38. Published online 2010 May 18. doi: 10.1186/bcr2535

PMCID:: PMC2875600

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Mitochondrial translocator protein modulates metabolism and pharmacologically induced apoptosis in breast cancer cells

A Gastaldello, P Gami, H Callaghan, M Campanella

Breast Cancer Res. 2010; 12(Suppl 1): P39. Published online 2010 May 18. doi: 10.1186/bcr2536

PMCID:: PMC2875601

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Identification of proteins and signalling pathways involved in neoadjuvant chemotherapy responsiveness of breast tumours using proteomics

CR Greenwood, LC Alldridge, S Chandra Sekharan, K Al-Janabi, P Sauven, S Souchelnytskyi

Breast Cancer Res. 2010; 12(Suppl 1): P40. Published online 2010 May 18. doi: 10.1186/bcr2537

PMCID:: PMC2875602

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Reduced MCPH1 expression in breast cancer and response to chemotherapy

J Richardson, A Shaaban, M Kamal, I Ellis, V Speirs, A Green, SM Bell

Breast Cancer Res. 2010; 12(Suppl 1): P41. Published online 2010 May 18. doi: 10.1186/bcr2538

PMCID:: PMC2875603

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Anti-HER2 imaging agents for breast cancer imaging

B Tolner, K Vigor, S Mather, M Robinson, G Adams, A Plueckthun, K Chester

Breast Cancer Res. 2010; 12(Suppl 1): P42. Published online 2010 May 18. doi: 10.1186/bcr2539

PMCID:: PMC2875604

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Predicting interaction networks of breast cancer risk genes using multiple microarray data

K Yano

Breast Cancer Res. 2010; 12(Suppl 1): P43. Published online 2010 May 18. doi: 10.1186/bcr2540

PMCID:: PMC2875605

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Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency

E Lamers, FA McDyer, JM Mulligan, F Couch, KI Savage, NE O'Brien, PB Mullan, RD Kennedy, DP Harkin, JE Quinn

Breast Cancer Res. 2010; 12(Suppl 1): P44. Published online 2010 May 18. doi: 10.1186/bcr2541

PMCID:: PMC2875606

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FKBPL: a novel prognostic and predictive biomarker?

HD McKeen, C Byrne, PV Jithesh, C Donley, A Yakkundi, L McCallum, HO McCarthy, DG Hirst, T Robson

Breast Cancer Res. 2010; 12(Suppl 1): P45. Published online 2010 May 18. doi: 10.1186/bcr2542

PMCID:: PMC2875607

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Stick or switch? Audit of the use of switch therapy from tamoxifen to an aromatase inhibitor in breast cancer

S Weeraman, C Hunsley, M Wall, R Kirby

Breast Cancer Res. 2010; 12(Suppl 1): P46. Published online 2010 May 18. doi: 10.1186/bcr2543

PMCID:: PMC2875608

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Topoisomerase 2 alpha as a predictor of response to anthracycline neoadjuvant chemotherapy in locally advanced breast cancer

M Shehata, A Al-Attar, J Reis-Filho, I Ellis, A Mukherjee, S Chan

Breast Cancer Res. 2010; 12(Suppl 1): P47. Published online 2010 May 18. doi: 10.1186/bcr2544

PMCID:: PMC2875609

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CYP2D6 genotype affects outcome in postmenopausal breast cancer patients treated with tamoxifen monotherapy

AM Thompson, S Bray, AM Johnson, P Quinlan, DM Nikloff, DG Evans, R Clarke, HJ Lawrence, A Howell, A Latif, R Ferraldeschl, G Hillman, M Fontecha, WG Newman

Breast Cancer Res. 2010; 12(Suppl 1): P48. Published online 2010 May 18. doi: 10.1186/bcr2545

PMCID:: PMC2875610

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Recruitment of insulin receptor substrate-1 by erbB3 impacts on IGF-IR signalling in oestrogen receptor-positive breast cancer cells

JM Knowlden, JMW Gee, D Barrow, JF Robertson, IO Ellis, RI Nicholson, IR Hutcheson

Breast Cancer Res. 2010; 12(Suppl 1): P49. Published online 2010 May 18. doi: 10.1186/bcr2546

PMCID:: PMC2875611

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Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53 mutant Her2 and triple negative breast cancer

R Sainsbury, I Proctor, S Rodriguez, M Loddo, S Tudzarova, K Stoeber, G Williams

Breast Cancer Res. 2010; 12(Suppl 1): P50. Published online 2010 May 18. doi: 10.1186/bcr2547

PMCID:: PMC2875612

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Genetic engineering of pharmacologically regulated T cells, specific for breast cancer target antigens

S Wilkie, S Burbridge, DM Davies, L Chiapero-Stanke, J Foster, SJ Mather, J Maher

Breast Cancer Res. 2010; 12(Suppl 1): P51. Published online 2010 May 18. doi: 10.1186/bcr2548

PMCID:: PMC2875613

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Radiotherapy fraction size sensitivity is modulated by DNA repair systems

N Somaiah, J Yarnold, F Daley, A Pearson, K Rothkamm, T Helleday

Breast Cancer Res. 2010; 12(Suppl 1): P52. Published online 2010 May 18. doi: 10.1186/bcr2549

PMCID:: PMC2875614

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Opticin: a potent anti-angiogenic/antiproliferative agent for breast cancer therapy

SF Sneddon, BA Telfer, KJ Williams, PN Bishop, IJ Stratford, RL Cowen

Breast Cancer Res. 2010; 12(Suppl 1): P53. Published online 2010 May 18. doi: 10.1186/bcr2550

PMCID:: PMC2875615

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Completion of 5-year adjuvant endocrine therapy in the community

B Makubate, AM Thompson, JA Dewar, C McCowan

Breast Cancer Res. 2010; 12(Suppl 1): P54. Published online 2010 May 18. doi: 10.1186/bcr2551

PMCID:: PMC2875616

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Psychosocial impact of breast cancer diagnosis and treatment in African, Caribbean and South Asian women

G Patel, D Harcourt, N Rumsey, H Naqvi

Breast Cancer Res. 2010; 12(Suppl 1): P55. Published online 2010 May 18. doi: 10.1186/bcr2552

PMCID:: PMC2875617

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Intensity and features of acute postoperative pain after mastectomy and breast-conserving surgery

S Marfizo, AJ Thornton, NW Scott, AM Thompson, SD Hays, J Bruce

Breast Cancer Res. 2010; 12(Suppl 1): P56. Published online 2010 May 18. doi: 10.1186/bcr2553

PMCID:: PMC2875618

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Breast cancer knowledge among women with learning disabilities and their experiences of breast mammography

LG Taggart, S McIlfatrick, MN Truesdale-Kennedy

Breast Cancer Res. 2010; 12(Suppl 1): P57. Published online 2010 May 18. doi: 10.1186/bcr2554

PMCID:: PMC2875619

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A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis

D Twiddy, S Naik, R Mistry, J Edwards, RA Walker, GM Cohen, M MacFarlane

Breast Cancer Res. 2010; 12(Suppl 1): P58. Published online 2010 May 18. doi: 10.1186/bcr2555

PMCID:: PMC2875620

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Modelling breast cancer in a three-dimensional heterotypic culture system

DL Holliday, S Maltby, MA Moss, AM Hanby, JL Jones, V Speirs

Breast Cancer Res. 2010; 12(Suppl 1): P59. Published online 2010 May 18. doi: 10.1186/bcr2556

PMCID:: PMC2875621

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