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Volume 11(1);  March 2009
Review Articles
Protein Binding of Antimicrobials: Methods for Quantification and for Investigation of its Impact on Bacterial Killing
Jürgen Beer, Claudia Christina Wagner, Markus Zeitlinger
AAPS J. 2009 March; 11(1): 1–12. Published online 2009 January 1. doi: 10.1208/s12248-008-9072-1
PMCID:
PMC2664873
Abstract Full Text PDF–294K
Targeted Delivery Systems for Oligonucleotide Therapeutics
Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
AAPS J. 2009 March; 11(1): 195–203. Published online 2009 March 19. doi: 10.1208/s12248-009-9096-1
PMCID:
PMC2664895
Abstract Full Text PDF–235K
Emerging Drug Delivery Technologies
Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment
Ayman El-Sayed, Shiroh Futaki, Hideyoshi Harashima
AAPS J. 2009 March; 11(1): 13–22. Published online 2009 January 6. doi: 10.1208/s12248-008-9071-2
PMCID:
PMC2664872
Abstract Full Text PDF–311K
Targeted Delivery of Nucleic Acid-Based Therapeutics to the Pulmonary Circulation
Ramalinga Kuruba, Annette Wilson, Xiang Gao, Song Li
AAPS J. 2009 March; 11(1): 23–30. Published online 2009 January 9. doi: 10.1208/s12248-008-9073-0
PMCID:
PMC2664874
Abstract Full Text PDF–200K
Learning from the Viral Journey: How to Enter Cells and How to Overcome Intracellular Barriers to Reach the Nucleus
Diky Mudhakir, Hideyoshi Harashima
AAPS J. 2009 March; 11(1): 65–77. Published online 2009 February 5. doi: 10.1208/s12248-009-9080-9
PMCID:
PMC2664881
Abstract Full Text PDF–407K
Vaginal Drug Delivery Systems for HIV Prevention
Lisa Cencia Rohan, Alexandra B. Sassi
AAPS J. 2009 March; 11(1): 78–87. Published online 2009 February 5. doi: 10.1208/s12248-009-9082-7
PMCID:
PMC2664883
Abstract Full Text PDF–194K
Poly(ethylene glycol)-Modified Proteins: Implications for Poly(lactide-co-glycolide)-Based Microsphere Delivery
Sheetal S. Pai, Robert D. Tilton, Todd M. Przybycien
AAPS J. 2009 March; 11(1): 88–98. Published online 2009 February 6. doi: 10.1208/s12248-009-9081-8
PMCID:
PMC2664882
Abstract Full Text PDF–245K
Quantitative Pharmacology, a Roadmap for Rational, Model-Based Drug Development
The Use of Clinical Utility Assessments in Early Clinical Development
Anis A. Khan, Itay Perlstein, Rajesh Krishna
AAPS J. 2009 March; 11(1): 33–38. Published online 2009 January 16. doi: 10.1208/s12248-008-9074-z
PMCID:
PMC2664875
Abstract Full Text PDF–140K
Nida Symposium: Drugs of Abuse: Special Topics in Drug Development
Targeting Fatty Acid Amide Hydrolase (FAAH) to Treat Pain and Inflammation
Joel E. Schlosburg, Steven G. Kinsey, Aron H. Lichtman
AAPS J. 2009 March; 11(1): 39–44. Published online 2009 January 29. doi: 10.1208/s12248-008-9075-y
PMCID:
PMC2664876
Abstract Full Text PDF–123K
Glial–Neuronal Interactions—Implications for Plasticity and Drug Addiction
Sukumar Vijayaraghavan
AAPS J. 2009 March; 11(1): 123–132. Published online 2009 February 24. doi: 10.1208/s12248-009-9085-4
PMCID:
PMC2664886
Abstract Full Text PDF–256K
Towards Integrated Adme Prediction: Past, Present, and Future Directions
Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects
N. Parrott, V. Lukacova, G. Fraczkiewicz, M. B. Bolger
AAPS J. 2009 March; 11(1): 45–53. Published online 2009 January 29. doi: 10.1208/s12248-008-9079-7
PMCID:
PMC2664880
Abstract Full Text PDF–205K
Research Articles
Elastic Liposomal Formulation for Sustained Delivery of Colchicine: In Vitro Characterization and In Vivo Evaluation of Anti-gout Activity
Hardevinder Pal Singh, Puneet Utreja, Ashok Kumar Tiwary, Subheet Jain
AAPS J. 2009 March; 11(1): 54–64. Published online 2009 February 4. doi: 10.1208/s12248-008-9078-8
PMCID:
PMC2664879
Abstract Full Text PDF–523K
Model-Based Decision Making in Early Clinical Development: Minimizing the Impact of a Blood Pressure Adverse Event
Mark Stroh, Carol Addy, Yunhui Wu, S. Aubrey Stoch, Nazaneen Pourkavoos, Michelle Groff, Yang Xu, John Wagner, Keith Gottesdiener, Craig Shadle, Hong Wang, Kimberly Manser, Gregory A. Winchell, Julie A. Stone
AAPS J. 2009 March; 11(1): 99–108. Published online 2009 February 6. doi: 10.1208/s12248-009-9083-6
PMCID:
PMC2664884
Abstract Full Text PDF–253K
Screening for Potential Adjuvants Administered by the Pulmonary Route for Tuberculosis Vaccines
Chenchen Wang, Pavan Muttil, Dongmei Lu, Adela Ayulia Beltran-Torres, Lucila Garcia-Contreras, Anthony J. Hickey
AAPS J. 2009 March; 11(1): 139–147. Published online 2009 March 10. doi: 10.1208/s12248-009-9089-0
PMCID:
PMC2664889
Abstract Full Text PDF–377K
Modeling Subpopulations with the $MIXTURE Subroutine in NONMEM: Finding the Individual Probability of Belonging to a Subpopulation for the Use in Model Analysis and Improved Decision Making
Kristin C. Carlsson, Radojka M. Savi, Andrew C. Hooker, Mats O. Karlsson
AAPS J. 2009 March; 11(1): 148–154. Published online 2009 March 10. doi: 10.1208/s12248-009-9093-4
PMCID:
PMC2664892
Abstract Full Text PDF–216K
Modelling and PBPK Simulation in Drug Discovery
Hannah M. Jones, Iain B. Gardner, Kenny J. Watson
AAPS J. 2009 March; 11(1): 155–166. Published online 2009 March 12. doi: 10.1208/s12248-009-9088-1
PMCID:
PMC2664888
Abstract Full Text PDF–312K
Prediction of the Deposition of Dry Powder Aerosols
Pedro J. Mendes, João M. M. Sousa, João F. Pinto
AAPS J. 2009 March; 11(1): 186–194. Published online 2009 March 19. doi: 10.1208/s12248-009-9095-2
PMCID:
PMC2664894
Abstract Full Text PDF–495K
Nida Symposium: Drugs of Abuse: Drug Development and Cannabinoids
Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
Sumner H. Burstein, Robert B. Zurier
AAPS J. 2009 March; 11(1): 109–119. Published online 2009 February 6. doi: 10.1208/s12248-009-9084-5
PMCID:
PMC2664885
Abstract Full Text PDF–252K
Brief/Technical Note
Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants II: Role of Plasma Esterases in Drug Release
Xiuling Lu, Melissa D. Howard, Dominique R. Talbert, John J. Rinehart, Philip M. Potter, Michael Jay, Markos Leggas
AAPS J. 2009 March; 11(1): 120–122. Published online 2009 February 19. doi: 10.1208/s12248-009-9086-3
PMCID:
PMC2664887
Full Text PDF–96K
Meeting Report
Antidrug Antibody Assay Validation: Industry Survey Results
Boris Gorovits
AAPS J. 2009 March; 11(1): 133–138. Published online 2009 March 3. doi: 10.1208/s12248-009-9091-6
PMCID:
PMC2664891
Abstract Full Text PDF–109K
Mini-Reviews
Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery
Henry A. Lester, Cheng Xiao, Rahul Srinivasan, Cagdas D. Son, Julie Miwa, Rigo Pantoja, Matthew R. Banghart, Dennis A. Dougherty, Alison M. Goate, Jen C. Wang
AAPS J. 2009 March; 11(1): 167–177. Published online 2009 March 12. doi: 10.1208/s12248-009-9090-7
PMCID:
PMC2664890
Abstract Full Text PDF–222K
Recent Advances in Structure-Based Virtual Screening of G-Protein Coupled Receptors
Subramaniam Ananthan, Wei Zhang, Judith Varady Hobrath
AAPS J. 2009 March; 11(1): 178–185. Published online 2009 March 17. doi: 10.1208/s12248-009-9094-3
PMCID:
PMC2664893
Abstract Full Text PDF–229K
Errata
Understanding the Effect of API Properties on Bioavailability Through Absorption Modeling
Filippos Kesisoglou, Yunhui Wu
AAPS J. 2009 March; 11(1): 31. Published online 2009 January 15. doi: 10.1208/s12248-008-9076-x
Corrects:
AAPS J. 2008 December; 10(4): 516–525.
PMCID:
PMC2664877
Correction PDF–36K Original Article
Drug Absorption Modeling as a Tool to Define the Strategy in Clinical Formulation Development
Martin Kuentz
AAPS J. 2009 March; 11(1): 32. Published online 2009 January 15. doi: 10.1208/s12248-008-9077-9
Corrects:
AAPS J. 2008 September; 10(3): 473–479.
PMCID:
PMC2664878
Correction PDF–35K Original Article
Articles from The AAPS Journal are provided here courtesy of
American Association of Pharmaceutical Scientists