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Volume 50(3);  March 2006
Mechanisms of Action: Physiological Effects
Pharmacodynamic Evaluation of the Intracellular Activities of Antibiotics against Staphylococcus aureus in a Model of THP-1 Macrophages
Maritza Barcia-Macay, Cristina Seral, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, Françoise Van Bambeke
Antimicrob Agents Chemother. 2006 March; 50(3): 841–851. doi: 10.1128/AAC.50.3.841-851.2006
PMCID:
PMC1426441
Abstract Full Text PDF–431K
Structural Correlates of Antibacterial and Membrane-Permeabilizing Activities in Acylpolyamines
Rajalakshmi Balakrishna, Stewart J. Wood, Thuan B. Nguyen, Kelly A. Miller, E. V. K. Suresh Kumar, Apurba Datta, Sunil A. David
Antimicrob Agents Chemother. 2006 March; 50(3): 852–861. doi: 10.1128/AAC.50.3.852-861.2006
PMCID:
PMC1426419
Abstract Full Text PDF–256K
Rate of Elimination of Wolbachia pipientis by Doxycycline In Vitro Increases following Drug Withdrawal
Benjamin L. Makepeace, Lisa Rodgers, Alexander J. Trees
Antimicrob Agents Chemother. 2006 March; 50(3): 922–927. doi: 10.1128/AAC.50.3.922-927.2006
PMCID:
PMC1426454
Abstract Full Text PDF–111K
Involvement of Reactive Oxygen Species in the Action of Ciprofloxacin against Escherichia coli
M. Goswami, S. H. Mangoli, N. Jawali
Antimicrob Agents Chemother. 2006 March; 50(3): 949–954. doi: 10.1128/AAC.50.3.949-954.2006
PMCID:
PMC1426460
Abstract Full Text PDF–111K
Mechanisms of Resistance
Molecular Epidemiology of Acquired-Metallo-β-Lactamase-Producing Bacteria in Poland
Janusz Fiett, Anna Baraniak, Agnieszka Mrówka, Małgorzata Fleischer, Zuzanna Drulis-Kawa, Łukasz Naumiuk, Alfred Samet, Waleria Hryniewicz, Marek Gniadkowski
Antimicrob Agents Chemother. 2006 March; 50(3): 880–886. doi: 10.1128/AAC.50.3.880-886.2006
PMCID:
PMC1426447
Abstract Full Text PDF–98K
Effect of Efflux on Telithromycin and Macrolide Susceptibility in Haemophilus influenzae
Tatiana Bogdanovich, Bülent Bozdogan, Peter C. Appelbaum
Antimicrob Agents Chemother. 2006 March; 50(3): 893–898. doi: 10.1128/AAC.50.3.893-898.2006
PMCID:
PMC1426444
Abstract Full Text PDF–75K
Fluoroquinolone Resistance in Invasive Streptococcus pyogenes Isolates Due to Spontaneous Mutation and Horizontal Gene Transfer
M. W. R. Pletz, L. McGee, C. A. Van Beneden, S. Petit, M. Bardsley, M. Barlow, K. P. Klugman
Antimicrob Agents Chemother. 2006 March; 50(3): 943–948. doi: 10.1128/AAC.50.3.943-948.2006
PMCID:
PMC1426425
Abstract Full Text PDF–169K
Biochemical and Molecular Characterization of Three New Variants of AmpC β-Lactamases from Morganella morganii
Pablo Power, Moreno Galleni, Juan A. Ayala, Gabriel Gutkind
Antimicrob Agents Chemother. 2006 March; 50(3): 962–967. doi: 10.1128/AAC.50.3.962-967.2006
PMCID:
PMC1426437
Abstract Full Text PDF–108K
Staphylococcal Cassette Chromosome mec (SCCmec) Typing of Methicillin-Resistant Staphylococcus aureus Strains Isolated in 11 Asian Countries: a Proposal for a New Nomenclature for SCCmec Elements
Piriyaporn Chongtrakool, Teruyo Ito, Xiao Xue Ma, Yoko Kondo, Suwanna Trakulsomboon, Chuntima Tiensasitorn, Mantana Jamklang, Tavinun Chavalit, Jae-Hoon Song, Keiichi Hiramatsu
Antimicrob Agents Chemother. 2006 March; 50(3): 1001–1012. doi: 10.1128/AAC.50.3.1001-1012.2006
PMCID:
PMC1426434
Abstract Full Text PDF–588K
Transfer of Vancomycin Resistance Transposon Tn1549 from Clostridium symbiosum to Enterococcus spp. in the Gut of Gnotobiotic Mice
Aline Launay, Susan A. Ballard, Paul D. R. Johnson, M. Lindsay Grayson, Thierry Lambert
Antimicrob Agents Chemother. 2006 March; 50(3): 1054–1062. doi: 10.1128/AAC.50.3.1054-1062.2006
PMCID:
PMC1426432
Abstract Full Text PDF–618K
Enterococcus gallinarum N04-0414 Harbors a VanD-Type Vancomycin Resistance Operon and Does Not Contain a d-Alanine:d-Alanine 2 (ddl2) Gene
David A. Boyd, Mark A. Miller, Michael R. Mulvey
Antimicrob Agents Chemother. 2006 March; 50(3): 1067–1070. doi: 10.1128/AAC.50.3.1067-1070.2006
PMCID:
PMC1426452
Abstract Full Text PDF–130K
Medium Plays a Role in Determining Expression of acrB, marA, and soxS in Escherichia coli
Andrew M. Bailey, Mark A. Webber, Laura J. V. Piddock
Antimicrob Agents Chemother. 2006 March; 50(3): 1071–1074. doi: 10.1128/AAC.50.3.1071-1074.2006
PMCID:
PMC1426439
Abstract Full Text PDF–69K
Molecular Characterization of Isoniazid Resistance in Mycobacterium tuberculosis: Identification of a Novel Mutation in inhA
E. T. Y. Leung, P. L. Ho, K. Y. Yuen, W. L. Woo, T. H. Lam, R. Y. Kao, W. H. Seto, W. C. Yam
Antimicrob Agents Chemother. 2006 March; 50(3): 1075–1078. doi: 10.1128/AAC.50.3.1075-1078.2006
PMCID:
PMC1426451
Abstract Full Text PDF–105K
Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus
Longzhu Cui, Eiji Tominaga, Hui-min Neoh, Keiichi Hiramatsu
Antimicrob Agents Chemother. 2006 March; 50(3): 1079–1082. doi: 10.1128/AAC.50.3.1079-1082.2006
PMCID:
PMC1426436
Abstract Full Text PDF–446K
Detection of Methicillin-Resistant Staphylococcus aureus Strains Resistant to Multiple Antibiotics and Carrying the Panton-Valentine Leukocidin Genes in an Algiers Hospital
Nadjia Ramdani-Bouguessa, Michèle Bes, Hélène Meugnier, Françoise Forey, Marie-Elisabeth Reverdy, Gerard Lina, François Vandenesch, Mohamed Tazir, Jerome Etienne
Antimicrob Agents Chemother. 2006 March; 50(3): 1083–1085. doi: 10.1128/AAC.50.3.1083-1085.2006
PMCID:
PMC1426459
Abstract Full Text PDF–140K
Staphylococcus Efflux msr(A) Gene Characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas Isolates
Kayode K. Ojo, Megan J. Striplin, Catherine C. Ulep, Natasha S. Close, Jennifer Zittle, Henrique Luis, Mario Bernardo, Jorge Leitao, Marilyn C. Roberts
Antimicrob Agents Chemother. 2006 March; 50(3): 1089–1091. doi: 10.1128/AAC.50.3.1089-1091.2006
PMCID:
PMC1426440
Abstract Full Text PDF–44K Supplementary Material
Roles of Cellular Respiration, CgCDR1, and CgCDR2 in Candida glabrata Resistance to Histatin 5
Eva J. Helmerhorst, Caterina Venuleo, Dominique Sanglard, Frank G. Oppenheim
Antimicrob Agents Chemother. 2006 March; 50(3): 1100–1103. doi: 10.1128/AAC.50.3.1100-1103.2006
PMCID:
PMC1426449
Abstract Full Text PDF–128K
NorC, a New Efflux Pump Regulated by MgrA of Staphylococcus aureus
Que Chi Truong-Bolduc, Jacob Strahilevitz, David C. Hooper
Antimicrob Agents Chemother. 2006 March; 50(3): 1104–1107. doi: 10.1128/AAC.50.3.1104-1107.2006
PMCID:
PMC1426456
Abstract Full Text PDF–107K
Susceptibility
In Vitro Activity of Novel Rifamycins against Rifamycin-Resistant Staphylococcus aureus
Christopher K. Murphy, Steve Mullin, Marcia S. Osburne, John van Duzer, Jim Siedlecki, Xiang Yu, Kathy Kerstein, Michael Cynamon, David M. Rothstein
Antimicrob Agents Chemother. 2006 March; 50(3): 827–834. doi: 10.1128/AAC.50.3.827-834.2006
PMCID:
PMC1426431
Abstract Full Text PDF–197K
Interlaboratory Comparison of PCR-Based Methods for Detection of Penicillin G Susceptibility in Neisseria meningitidis
Muhamed-Kheir Taha, Maria Leticia Zarantonelli, Arianna Neri, Rocío Enriquez, Julio A. Vázquez, Paola Stefanelli
Antimicrob Agents Chemother. 2006 March; 50(3): 887–892. doi: 10.1128/AAC.50.3.887-892.2006
PMCID:
PMC1426420
Abstract Full Text PDF–100K
Head-to-Head Comparison of the Activities of Currently Available Antifungal Agents against 3,378 Spanish Clinical Isolates of Yeasts and Filamentous Fungi
Manuel Cuenca-Estrella, Alicia Gomez-Lopez, Emilia Mellado, Maria J. Buitrago, Araceli Monzon, Juan Luis Rodriguez-Tudela
Antimicrob Agents Chemother. 2006 March; 50(3): 917–921. doi: 10.1128/AAC.50.3.917-921.2006
PMCID:
PMC1426453
Abstract Full Text PDF–69K
Susceptibility of Cryptococcus neoformans Biofilms to Antifungal Agents In Vitro
Luis R. Martinez, Arturo Casadevall
Antimicrob Agents Chemother. 2006 March; 50(3): 1021–1033. doi: 10.1128/AAC.50.3.1021-1033.2006
PMCID:
PMC1426450
Abstract Full Text PDF–2.3M
Activities of Telithromycin, Erythromycin, Fluoroquinolones, and Doxycycline against Campylobacter Strains Isolated from Finnish Subjects
Daniela Schönberg-Norio, Marja-Liisa Hänninen, Marja-Leena Katila, Suvi-Sirkku Kaukoranta, Markku Koskela, Erkki Eerola, Jaakko Uksila, Sini Pajarre, Hilpi Rautelin
Antimicrob Agents Chemother. 2006 March; 50(3): 1086–1088. doi: 10.1128/AAC.50.3.1086-1088.2006
PMCID:
PMC1426464
Abstract Full Text PDF–91K
Potent In Vitro Synergism of Fluconazole and Berberine Chloride against Clinical Isolates of Candida albicans Resistant to Fluconazole
Hua Quan, Ying-Ying Cao, Zheng Xu, Jing-Xia Zhao, Ping-Hui Gao, Xiao-Feng Qin, Yuan-Ying Jiang
Antimicrob Agents Chemother. 2006 March; 50(3): 1096–1099. doi: 10.1128/AAC.50.3.1096-1099.2006
PMCID:
PMC1426442
Abstract Full Text PDF–167K
Evaluation of Disk Diffusion Method for Determining Posaconazole Susceptibility of Filamentous Fungi: Comparison with CLSI Broth Microdilution Method
E. López-Oviedo, A. I. Aller, C. Martín, C. Castro, M. Ramirez, J. M. Pemán, E. Cantón, C. Almeida, E. Martín-Mazuelos
Antimicrob Agents Chemother. 2006 March; 50(3): 1108–1111. doi: 10.1128/AAC.50.3.1108-1111.2006
PMCID:
PMC1426461
Abstract Full Text PDF–82K
Activities of Tizoxanide and Nitazoxanide Compared to Those of Five Other Thiazolides and Three Other Agents against Anaerobic Species
Glenn A. Pankuch, Peter C. Appelbaum
Antimicrob Agents Chemother. 2006 March; 50(3): 1112–1117. doi: 10.1128/AAC.50.3.1112-1117.2006
PMCID:
PMC1426457
Abstract Full Text PDF–64K
Biologic Response Modifiers
Effects of Lipid Formulations of Amphotericin B on Activity of Human Monocytes against Aspergillus fumigatus
J. Dotis, M. Simitsopoulou, M. Dalakiouridou, T. Konstantinou, A. Taparkou, F. Kanakoudi-Tsakalidou, T. J. Walsh, E. Roilides
Antimicrob Agents Chemother. 2006 March; 50(3): 868–873. doi: 10.1128/AAC.50.3.868-873.2006
PMCID:
PMC1426430
Abstract Full Text PDF–117K
Antiviral Agents
Lack of Evidence for In Vivo Transformation of Zidovudine Triphosphate to Stavudine Triphosphate in Human Immunodeficiency Virus-Infected Patients
Margarita Meléndez, Raúl Blanco, Wilfredo Delgado, Rosario García, Jorge Santana, Hermes García, Osvaldo Rosario, José F. Rodríguez
Antimicrob Agents Chemother. 2006 March; 50(3): 835–840. doi: 10.1128/AAC.50.3.835-840.2006
PMCID:
PMC1426443
Abstract Full Text PDF–212K
Pharmacokinetics of Telbivudine following Oral Administration of Escalating Single and Multiple Doses in Patients with Chronic Hepatitis B Virus Infection: Pharmacodynamic Implications
Xiao-Jian Zhou, Seng-Gee Lim, Deborah M. Lloyd, George C. Chao, Nathaniel A. Brown, Ching-Lung Lai
Antimicrob Agents Chemother. 2006 March; 50(3): 874–879. doi: 10.1128/AAC.50.3.874-879.2006
PMCID:
PMC1426427
Abstract Full Text PDF–215K
Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease
Robert B. Perni, Susan J. Almquist, Randal A. Byrn, Gurudatt Chandorkar, Pravin R. Chaturvedi, Lawrence F. Courtney, Caroline J. Decker, Kirk Dinehart, Cynthia A. Gates, Scott L. Harbeson, Angela Heiser, Gururaj Kalkeri, Elaine Kolaczkowski, Kai Lin, Yu-Ping Luong, B. Govinda Rao, William P. Taylor, John A. Thomson, Roger D. Tung, Yunyi Wei, Ann D. Kwong, Chao Lin
Antimicrob Agents Chemother. 2006 March; 50(3): 899–909. doi: 10.1128/AAC.50.3.899-909.2006
PMCID:
PMC1426435
Abstract Full Text PDF–311K
In Vitro Characterization of the Anti-Hepatitis B Virus Activity and Cross-Resistance Profile of 2′,3′-Dideoxy-3′-Fluoroguanosine
A.-C. Jacquard, M.-N. Brunelle, C. Pichoud, D. Durantel, S. Carrouée-Durantel, C. Trepo, F. Zoulim
Antimicrob Agents Chemother. 2006 March; 50(3): 955–961. doi: 10.1128/AAC.50.3.955-961.2006
PMCID:
PMC1426422
Abstract Full Text PDF–149K
VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice
Sven Enterlein, Kelly L. Warfield, Dana L. Swenson, David A. Stein, Jeffery L. Smith, C. Scott Gamble, Andrew D. Kroeker, Patrick L. Iversen, Sina Bavari, Elke Mühlberger
Antimicrob Agents Chemother. 2006 March; 50(3): 984–993. doi: 10.1128/AAC.50.3.984-993.2006
PMCID:
PMC1426423
Abstract Full Text PDF–360K
SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
B. A. Malcolm, R. Liu, F. Lahser, S. Agrawal, B. Belanger, N. Butkiewicz, R. Chase, F. Gheyas, A. Hart, D. Hesk, P. Ingravallo, C. Jiang, R. Kong, J. Lu, J. Pichardo, A. Prongay, A. Skelton, X. Tong, S. Venkatraman, E. Xia, V. Girijavallabhan, F. G. Njoroge
Antimicrob Agents Chemother. 2006 March; 50(3): 1013–1020. doi: 10.1128/AAC.50.3.1013-1020.2006
PMCID:
PMC1426438
Abstract Full Text PDF–311K
Potent Antiscrapie Activities of Degenerate Phosphorothioate Oligonucleotides
David A. Kocisko, Andrew Vaillant, Kil Sun Lee, Kevin M. Arnold, Nadine Bertholet, Richard E. Race, Emily A. Olsen, Jean-Marc Juteau, Byron Caughey
Antimicrob Agents Chemother. 2006 March; 50(3): 1034–1044. doi: 10.1128/AAC.50.3.1034-1044.2006
PMCID:
PMC1426446
Abstract Full Text PDF–612K
Inactivation of Herpes Simplex Virus Clinical Isolates by Using a Combination Microbicide
Charles E. Isaacs, Lisa Rohan, Weimin Xu, Jun Hua Jia, Timothy Mietzner, Sharon Hillier
Antimicrob Agents Chemother. 2006 March; 50(3): 1063–1066. doi: 10.1128/AAC.50.3.1063-1066.2006
PMCID:
PMC1426429
Abstract Full Text PDF–118K
In Vitro Development of Resistance to Human Immunodeficiency Virus Protease Inhibitor GW640385
P. J. Yates, R. Hazen, M. St. Clair, L. Boone, M. Tisdale, R. C. Elston
Antimicrob Agents Chemother. 2006 March; 50(3): 1092–1095. doi: 10.1128/AAC.50.3.1092-1095.2006
PMCID:
PMC1426426
Abstract Full Text PDF–142K
Experimental Therapeutics
Efficacy and Potential for Resistance Selection of Antipseudomonal Treatments in a Mouse Model of Lung Infection by Hypermutable Pseudomonas aeruginosa
M. D. Maciá, N. Borrell, M. Segura, C. Gómez, J. L. Pérez, A. Oliver
Antimicrob Agents Chemother. 2006 March; 50(3): 975–983. doi: 10.1128/AAC.50.3.975-983.2006
PMCID:
PMC1426455
Abstract Full Text PDF–239K
Mefloquine Induces Dose-Related Neurological Effects in a Rat Model
G. Dow, R. Bauman, D. Caridha, M. Cabezas, F. Du, R. Gomez-Lobo, M. Park, K. Smith, K. Cannard
Antimicrob Agents Chemother. 2006 March; 50(3): 1045–1053. doi: 10.1128/AAC.50.3.1045-1053.2006
PMCID:
PMC1426433
Abstract Full Text PDF–356K
Clinical Therapeutics
Telavancin versus Standard Therapy for Treatment of Complicated Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: FAST 2 Study
Martin E. Stryjewski, Vivian H. Chu, William D. O'Riordan, Brian L. Warren, Lala M. Dunbar, David M. Young, Marc Vallée, Vance G. Fowler, Jr., Joel Morganroth, Steven L. Barriere, Michael M. Kitt, G. Ralph Corey, for the FAST 2 Investigator Group
Antimicrob Agents Chemother. 2006 March; 50(3): 862–867. doi: 10.1128/AAC.50.3.862-867.2006
PMCID:
PMC1426424
Abstract Full Text PDF–71K
Age-Related Effects on Nelfinavir and M8 Pharmacokinetics: a Population Study with 182 Children
Déborah Hirt, Saïk Urien, Vincent Jullien, Ghislaine Firtion, Elisabeth Rey, Gérard Pons, Stéphane Blanche, Jean-Marc Treluyer
Antimicrob Agents Chemother. 2006 March; 50(3): 910–916. doi: 10.1128/AAC.50.3.910-916.2006
PMCID:
PMC1426418
Abstract Full Text PDF–132K
Pharmacokinetic and Safety Evaluation of High-Dose Combinations of Fosamprenavir and Ritonavir
Mark J. Shelton, Mary Beth Wire, Yu Lou, Brigette Adamkiewicz, Sherene S. Min
Antimicrob Agents Chemother. 2006 March; 50(3): 928–934. doi: 10.1128/AAC.50.3.928-934.2006
PMCID:
PMC1426463
Abstract Full Text PDF–92K
Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea
Harin A. Karunajeewa, John Reeder, Kerry Lorry, Elizah Dabod, Juliana Hamzah, Madhu Page-Sharp, Gregory M. Chiswell, Kenneth F. Ilett, Timothy M. E. Davis
Antimicrob Agents Chemother. 2006 March; 50(3): 968–974. doi: 10.1128/AAC.50.3.968-974.2006
PMCID:
PMC1426445
Abstract Full Text PDF–129K
Pharmacokinetic-Pharmacodynamic Relationships Describing the Efficacy of Oritavancin in Patients with Staphylococcus aureus Bacteremia
Sujata M. Bhavnani, Julie A. Passarell, Joel S. Owen, Jeffrey S. Loutit, Steven B. Porter, Paul G. Ambrose
Antimicrob Agents Chemother. 2006 March; 50(3): 994–1000. doi: 10.1128/AAC.50.3.994-1000.2006
PMCID:
PMC1426428
Abstract Full Text PDF–80K
Pharmacology
Population Pharmacokinetics of Liposomal Amphotericin B in Pediatric Patients with Malignant Diseases
Ying Hong, Peter J. Shaw, Christa E. Nath, Satya P. Yadav, Katherine R. Stephen, John W. Earl, Andrew J. McLachlan
Antimicrob Agents Chemother. 2006 March; 50(3): 935–942. doi: 10.1128/AAC.50.3.935-942.2006
PMCID:
PMC1426421
Abstract Full Text PDF–111K
Letters to the Editor
Nuclear Translocation Peptides as Antibiotics
Nahoko Kobayashi, Yoshinao Yamada, Tetsuhiko Yoshida
Antimicrob Agents Chemother. 2006 March; 50(3): 1118–1119. doi: 10.1128/AAC.50.3.1118-1119.2006
PMCID:
PMC1426448
Full Text PDF–36K
Catheter Lock and Systemic Infusion of Linezolid for Treatment of Persistent Broviac Catheter-Related Staphylococcal Bacteremia
Elio Castagnola, Cristina Moroni, Paolo Gandullia, Mauro Oddone, Cristiano Peri, Rosaria Casciaro, Alessandra De Alessandri
Antimicrob Agents Chemother. 2006 March; 50(3): 1120–1121. doi: 10.1128/AAC.50.3.1120-1121.2006
PMCID:
PMC1426458
Full Text PDF–33K
Erratum
In Vivo Efficacies and Pharmacokinetics of DX-619, a Novel Des-Fluoro(6) Quinolone, against Streptococcus pneumoniae in a Mouse Lung Infection Model
Yuichi Fukuda, Katsunori Yanagihara, Hideaki Ohno, Yasuhito Higashiyama, Yoshitsugu Miyazaki, Kazuhiro Tsukamoto, Yoichi Hirakata, Kazunori Tomono, Yohei Mizuta, Takayoshi Tashiro, Shigeru Kohno
Antimicrob Agents Chemother. 2006 March; 50(3): 1122. doi: 10.1128/AAC.50.3.1122.2006
Corrects:
Antimicrob Agents Chemother. 2006 January; 50(1): 121–125.
PMCID:
PMC1426462
Correction PDF–17K Original Article
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