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Table 4.

Proteins in signaling and cell cycle pathways involved in eye development
ProteinESTsNIA 15k
FGF-1526No
SFRP-2 (secreted frizzled-related protein 2)20No
Cyclin D119Yes
Calmodulin15Yes
SCG10 (stathmin homolog)11No
Beta catenin10Yes
GAP-43 (neuromodulin)6Yes
Ulip (UNC-33-like phosphoprotein)6No
Ulip3 (collapsin response mediator 1)6No
Dkk-3 (Dickkopf gene)4Yes
EGF repeat transmembrane protein DBI-1 (related to Notch)3Yes
Manic fringe3Yes
Robo2 (repulsive guidance receptor roundabout 2)3No
SMO (smoothened homolog)3No
MAB21L23No
CDC422Yes
Nogo-A/Reticulon 4-A (inhibitor of neurite growth)2Yes
MAB21L1/CAGR1 (Mab-21 homolog)2No
P35 (CDK5 regulatory subunit 1)2No
Axin 12Yes
Su(H) (suppressor of hairless)2No
Numb2No
Plexin-B1/SEP receptor2Yes
Plexin 21No
Sema4g (semaphorin subclass 4 member g)1Yes
Neuropilin-1 (semaphorin III receptor)1Yes
ICAT (beta catenin-interacting protein)1No
ELF-1/CEK7-L (EPH-related receptor tyrosine kinase ligand)1No
Notch4/INT-31No
Plexin 3 (transmembrane protein SEX)1Yes
Deltex (Notch signaling regulator)1No
Epherin-B11No
Chat (Cas and HEF1-associated signal transducer)1No
Reelin1No
SOS (son-of-sevenless-1)1Yes
mDab1 (Disabled homolog)1Yes
Semaphorin VIa1No
CDK5 (PSSALRE kinase)1Yes
DVL-2 (Dishevelled homolog)1No
Notch1/motch1No
Munc13–2 (UNC-13 homolog)1No