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From:

TABLE 5

Pharmacokinetics of stavudine in pediatric and adult patients with HIV infection following oral administration of various doses

Patient population Total dose (mg/kg/day [regimen]) Median [mean (SD)] pharmacokinetic parameter valuesa
Median [mean (SD)] pharmacokinetic parameter valuesa
Single dose
Steady state
Cmax (ng/ml) AUC0–∞ (ng · h/ml) CL/Fb (ml/min) t1/2 (h) Cmax (ng/ml) AUCτ (ng · h/ml) CL/F (ml/min)t1/2 (h)
Children 1.0 (0.5 mg/kg) 333 (353 [104]) (n = 8)671 (642 [231]) (n = 8)181 (196 [103]) (n = 8)0.90 (0.90 [0.28]) (n = 8)385 (424 [189]) (n = 8)672 (631 [237]) (n = 8)176 (198 [109]) (n = 8)1.07 (1.10 [0.23]) (n = 8)
2.0 (1.0 mg/kg) 692 (743 [146]) (n = 5c) 1,063 (1,270 [467]) (n = 5)258 (265 [83]) (n = 5)0.96 (0.96 [0.16]) (n = 5)845 (956 [612]) (n = 8)1,436 (1,439 [521]) (n = 8)212 (233 [109]) (n = 8)1.04 (1.06 [0.16]) (n = 8)
Adults 0.5 (0.25 mg/kg) 414 (385 [140]) (n = 5)484 (472 [52]) (n = 5)689 (714 [86]) (n = 5)1.28 (1.24 [0.17]) (n = 5) 356 (310 [92]) (n = 4d) 538 (565 [103]) (n = 4)620 (604 [99]) (n = 4)1.07 (1.27 [0.54]) (n = 4)
1.0 (0.5 mg/kg) 771 (720 [324]) (n = 9d) 1,201 (1,073 [414]) (n = 9)555 (659 [326]) (n = 9)1.39 (1.33 [0.40]) (n = 9)689 (857 [606]) (n = 10)1,194 (1,173 [370]) (n = 10)539 (574 [150]) (n = 10)1.32 (1.45 [0.44]) (n = 10)
aSingle-dose pharmacokinetic parameters were derived after administration of the first oral dose; steady-state pharmacokinetic parameters were derived for adults after at least 6 days of oral dosing and for children after at least 12 weeks of dosing. n, number of patients. 
bF, bioavailability. 
cData were not available for three patients. 
dData were not available for one patient.