Drug Interaction Studies of a Glucan Synthase Inhibitor  (LY 303366) and a Chitin Synthase Inhibitor (Nikkomycin Z)  for Inhibition and Killing of Fungal Pathogens

Antimicrob Agents Chemother. 2000 September; 44(9): 2547–2548.

PMCID: PMC90104

Note

Drug Interaction Studies of a Glucan Synthase Inhibitor (LY 303366) and a Chitin Synthase Inhibitor (Nikkomycin Z) for Inhibition and Killing of Fungal Pathogens

David A. Stevens^*

Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, California 95128, and Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, California 94305

^*Mailing address: Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave., San Jose, CA 95128-2699. Phone: (408) 885-4313. Fax: (408) 885-4306. E-mail: stevens/at/leland.stanford.edu.

Received February 1, 2000; Revisions requested April 12, 2000; Accepted June 7, 2000.

This article has been cited by other articles in PMC.

Abstract

The interaction between inhibitors of components of the fungal cell wall, glucan and chitin, was studied in vitro with the respective synthase enzyme inhibitors LY 303366 and nikkomycin Z. With Aspergillus fumigatus synergy was noted for inhibition and killing, and synergistic activity was also noted for some isolates of other species presently regarded as difficult to treat.

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