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Logo of bloodadvBlood Advances
Blood Adv. 2017 August 8; 1(18): 1466.
Published online 2017 August 8. doi:  10.1182/bloodadvances.2017004937
PMCID: PMC5727848

How many mice? Design considerations for murine studies


Murine experiments, like human experiments, require thoughtful design and sample size calculations. The statistical approaches to design are quite similar to those used for clinical trials, but the differences to be detected are larger, and the sample sizes consequently smaller, in the mouse experiments. As in human studies, it is important to articulate the end points of interest and how they will be measured, and to identify the additional sources of variability within the experiment, to assure the appropriate statistical approach for both design and analysis.

Supplementary Material

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Contribution: D.N. created and prepared this talk.

Conflict-of-interest disclosure: The author declares no competing financial interests.

Correspondence: Donna Neuberg, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, LC-1052, 450 Brookline Ave, Boston, MA 02215; e-mail: ude.dravrah.ymmij@grebuen.

Articles from Blood Advances are provided here courtesy of American Society of Hematology