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BMC Med Res Methodol. 2017; 17: 166.
Published online 2017 December 11. doi:  10.1186/s12874-017-0448-8
PMCID: PMC5725984

Methods to perform systematic reviews of patient preferences: a literature survey

Abstract

Background

Systematic reviews are a commonly used research design in the medical field to synthesize study findings. At present—although several systematic reviews of patient preference studies are published—there is no clear guidance available for researchers to conduct this type of systematic review. The aim of our study was to learn the most current practice of conducting these systematic reviews by conducting a survey of the literature regarding reviews of quantitative patient preference studies.

Methods

Our survey included systematic reviews of studies that used a stated quantitative preference design to elicit patient preferences. We identified eligible reviews through a search of the PubMed database. Two investigators with knowledge of the design of patient preference studies independently screened the titles and abstracts, and where needed, screened the full-text of the reviews to determine eligibility. We developed and pilot-tested a form to extract data on the methods used in each systematic review.

Results

Our search and screening identified 29 eligible reviews. A large proportion of the reviews (19/29, 66%) were published in 2014 or after; among them, nine reviews were published in 2016. The median number of databases searched for preference studies was four (interquartile range = 2 to 7). We found that less than half of the reviews (13/29, 45%) clearly reported assessing risk of bias or the methodological quality of the included preference studies; not a single review was able to perform quantitative synthesis (meta-analysis) of the data on patient preferences.

Conclusion

These results suggest that several methodological issues of performing systematic reviews of patient preferences are not yet fully addressed by research and that the methodology may require future development.

Keywords: Patient preference, Systematic review, Meta-analysis

Background

Making healthcare decisions is difficult since multi-dimensional factors are often involved. For example, when patients are in the situation to choose treatments for their conditions, they may need to jointly consider factors such as the benefits, harms, costs and inconveniences of each treatment in order to choose their most “preferred” option. Some patients are more concerned about the side effects of treatments; others may be more risk-tolerant. Thus, learning about patient preference information—or the “assessments of the relative desirability or acceptability to patients of specified alternatives” [1]—is critical in making an informed and patient-centered decision. It becomes even more important when multiple options exist, especially when it is unclear which option is superior or when the preferences vary considerably between patients [2].

Many regulatory agencies and health technology assessment bodies have also recognized the importance of studying patient preferences to improve their decision-making [3, 4]. Patient preference information can be elicited in qualitative studies such as patient interviews and focus groups. Or, it can be elicited quantitatively from a population of patients using the “stated preference” approaches developed mostly in the health economics field, including designs such as the rating scale, standard gamble, time trade-off or discrete choice experiment [5, 6]. In the end, individual patients may make their choices based on their own circumstances (socio-demographics, disease severity, comorbidities, or financial situations) and their own preferences. However, to make decisions such as drug approvals or reimbursement at a population level, preferences elicited from a survey of population can be beneficial to the decision-making for the entire population [7].

A systematic approach to studying patient preferences seems valuable. First, we need to conduct more preference-eliciting surveys and then do it across different populations to capture the heterogeneity, if such heterogeneity exists. When multiple preference-eliciting studies are done, a systematic review of these studies may then be needed to synthesize and summarize the study findings. Although several systematic reviews of patient preference studies are published, at present no standard guidance is available yet for researchers to conduct this type of systematic review.

Recently some efforts have been devoted to developing these review methodologies. For example, Yepes-Nuñez et al. [8] have done a systematic survey of patient preference reviews to identify items that previous reviewers have used in making risk of bias assessment of primary studies addressing preferences. They then grouped these items into seven domains for assessing the risk of bias, such as the instrument health state presentation. Besides risk of bias assessment, review methodologies for searches of preference studies, or qualitative and quantitative synthesis of primary study results are also highly needed from reviewers to conduct a preference review, which would be much different from that for a regular intervention review. Therefore, our goal was to gain an overview of the most current methods and practice that have been reported in the literature for conducting systematic reviews of quantitative patient preference studies.

Methods

Selection of studies

Our approach was not to perform a full systematic review of reviews, but rather to do a literature survey of systematic reviews. We focused on the methodology used by reviewers to conduct research synthesis of evidence on quantitative patient preferences. We restricted our selection of systematic reviews to the PubMed database. We adapted existing search filters [9, 10] and developed a strategy for the PubMed database with two concepts for the search: “systematic review” and “patient preferences” ((search[tiab] OR meta-analysis[pt] OR MEDLINE[tiab] OR (systematic[tiab] AND review[tiab])) AND (“patient preference”[mh] OR preference[ti] OR preferences[ti])). The search was performed on December 1, 2016.

Our pre-specified study inclusion criterion was any systematic review that aimed to synthesize quantitative evidence of patient preferences for attributes of an intervention or a health technology. This included medications, surgeries, medical devices, behavioral interventions, diagnostic tests and screening programs. The eligible systematic review had to include some studies using a quantitative stated preference design to assess patient preferences (such as the rating scale, visual analogue scale, standard gamble, time trade-off, contingent valuation, discrete choice experiment, or best-worst scaling). We excluded reviews that focused only on qualitative research. In some preference studies, participants were only asked to make choices between alternatives (for example, Drug A vs. Drug B) but the attributes of these alternatives (for example, benefits, harms, costs, and inconveniences) were not explicitly stated. We did not include reviews that focused only on this type of studies since they did not generate evidence on quantitative patient preferences for any attributes of an intervention or a health technology. Only English articles were included in our sample.

Two investigators with knowledge on the design of patient preference studies independently screened the list of search results to assess study eligibility by reviewing titles and abstracts. Where the reviewers could not make decisions on eligibility based on titles and abstracts alone, the full-text of each systematic review was downloaded and examined. Disagreement on the study eligibility was resolved through group discussion.

Data extraction and analysis

We developed and pilot-tested a data extraction form for this survey. The main items in the form included the following: objectives and conclusions of the systematic review, the criteria used to include/exclude patient preference studies, the methods used to search for preference studies, the methods used to assess the quality of preference studies, and the qualitative or quantitative methods used to synthesize study findings. One experienced reviewer independently performed the data extraction and assessment of methodology; another reviewer reviewed and checked the answers to each item in the form. Disagreement between the two reviewers was resolved by group discussion. We summarized these results in the tables of study characteristics.

Results

Search results

We identified 495 records from the search of the PubMed database. After title/abstract screening, 449 records were excluded, leaving 46 records. We excluded 17 records after full-text screening; the reasons for exclusion can be found in the Fig. 1. Most of the records were excluded because they focused on studies that assessed the preferences for alternatives (e.g., Drug A vs. Drug B) but the attributes of these alternatives were not explicitly stated in their assessment. Finally, we included 29 records (systematic reviews) in this literature survey.

Fig. 1
Study flow

Characteristics of included reviews

Table 1 lists the 29 included systematic reviews [1038]. The number of . About two-thirds (19/29) of the reviews were published in 2014 or after; among them, 9 reviews were published in 2016. About half of the included reviews were on cancers (14/29); three were on psoriasis; three were on type 2 diabetes; two were on attention-deficit/hyperactivity disorder, and the remaining seven reviews were each about different diseases. Among reviews on cancers (n = 14), 11 were studying the preferences for cancer treatment and three were studying preferences for cancer screening.

Table 1
Included systematic reviews

Table 2 shows the characteristics of these 29 included reviews. The median number of databases searched was four (interquartile range = 2 to 7). Six reviews (6/29, 21%) searched one database; four reviews (4/29, 14%) searched two; eleven reviews (11/29, 38%) searched three to five and eight reviews (8/29, 28%) searched more than five. All reviews (n = 29) searched for studies through PubMed or MEDLINE, 19/29 (66%) through EMBASE, 9/29 (31%) through CINAHL, 9/29 (31%) through PsycINFO, and 8/29 (28%) through EconLit. Almost half of the reviews (14/29, 48%) searched reference lists of the included studies. Few reviews searched for non-English articles (7/29, 24%) or for conference abstract/unpublished studies/grey literature (6/29, 21%). The search strategies used in each review to identify studies of patient preferences are summarized in Table 3. The terms developed by these reviews are focused mainly on “patient preferences” and the name of the study design used to elicit patient preferences.

Table 2
Characteristics of the systematic reviews
Table 3
Search strategies used for patient preferences

Most reviews (25/29, 86%) documented the methods used to assess study eligibility, for example, by mentioning the double and independent screening of title/abstract/full-text. Less than half of the reviews (13/29, 45%) clearly reported assessing the risk of bias or the methodological quality of the included preference studies. None of the reviews were able to perform quantitative synthesis (meta-analysis) of the preference data. The types of patient preference study design included in each review—such as the rating scale, visual analogue scale, standard gamble, time trade-off, contingent valuation, discrete choice experiment, and best-worst scaling—are listed in Table 4. A wide range of preference study designs is often included in this type of systematic reviews. Almost half of the reviews (14/29, 48%) were fully or partly funded by government, and 9/29 (31%) were funded by industry (see Table Table22).

Table 4
Types of included preference studies

Discussion

Our survey of the medical literature shows that there has been an increase in systematic reviews on patient preferences being published since 2014. This may suggest an increasing interest in conducting preference-eliciting studies, as well as systematic reviews of these studies. Almost half of the included reviews were on cancers, suggesting the strong interest from cancer researchers or their need to synthesize patient preference data. Although a number of this type of systematic reviews are published, many methodological issues regarding performing these systematic reviews are not yet fully addressed by previous research. For example, there is a lack of clear guidance or consensus on the approaches to searching for preference studies, to assessing methodological quality of preference studies, or to quantitatively synthesizing the data from preference studies.

Systematic reviews are a commonly used research design in the medical field to synthesize study findings—such as the treatment’s benefits, harms or costs—in order to inform evidence-based decision-making. Not only can systematic reviews summarize study results, they can also serve as a way to examine the heterogeneity in different studies or to identify the subgroups for which their results differ from others. There is a potentially large heterogeneity in the findings across patient preference studies, even for those addressing similar questions, because different researchers may use different preference designs, include different items for patients to assign preferences, and on top of that, socio-demographics are known to have great influences on preferences [39, 40]. Therefore, in many situations, systematic reviews may be a useful and necessary way to not only study patient preferences, but at the same time to also deal with these very heterogeneous studies, which poses great challenges to systematic reviewers.

Building up a comprehensive search strategy is one of the most important steps to conducting a systematic review. A comprehensive search strategy will identify as far as possible all relevant studies addressing the research question of interest, which can involve searching in different electronic databases, searching reference lists of included studies, searching for non-English articles, and searching for conference abstracts, unpublished studies or grey literature.

In our survey, most reviews had searched in databases beyond the PubMed/ MEDLINE database (median number of databases searched: 4), but only one-fifth to one-fourth of the reviews had searched for non-English articles (24%) or had searched for conference abstracts, unpublished studies or grey literature (21%). A few methodological questions regarding the search for patient preference studies are still not answered and deserve our attention. For example, are some of the databases such as EconLit (a database focusing on economics publications) required for searching for patient preference studies? Are preference data reported in conference abstracts useful to systematic reviewers? Is searching for non-English articles important? We need more methodological research to address these questions in order to support us in doing a comprehensive search, while at the same time not being lost in the literature. Also, we found that there was a wide range of search terms used by systematic reviewers to retrieve patient preference studies. This indicates the variety of terms used by most investigators to describe patient preferences and a need for search filters. Some groups have developed search filters for preference studies [41, 42], and more research on these search filters is needed to test for their validity.

Another issue we identified in our survey of reviews was that less than half of the studies reported assessing risk of bias or the methodological quality of patient preference studies. Methods to assess study quality/risk of bias of randomized controlled trials, for example, are mature because lots of research efforts have been dedicated to developing assessment tools for this. In our survey, some reviewers such as Purnell and colleagues adapted other existing tools or constructed checklists themselves when they were appraising the study quality [29]. They assessed whether the preference study had properly addressed purposes, respondents, explanation, findings, and significance. Others such as the U.S. Food and Drug Administration also listed several quality standards for patient preference studies in one of their guides [2] and researchers from McMaster University have generated 23 items for assessing the risk of bias in preference studies [8]. Implementing the methodological quality assessment tools for patient preference studies in actual practice would be challenging since there are so many different types of study designs available. We need more research to develop a standard way that can be used by most systematic reviewers to appraise the quality of preference studies.

In a systematic review of randomized controlled trials, meta-analyses (quantitative synthesis) are performed to synthesize data in order to generate more precise estimates. When it is difficult or not reasonable to combine study data, systematic reviewers may choose not to perform a meta-analysis. We found in our survey that no review was able to perform a meta-analysis of patient preferences, because for instance some preference studies may use a visual analogue scale approach and report preference weight ranging from zero to a hundred; some studies may conduct a discrete choice experiment and report coefficients from a conditional logistic regression model. Moreover, these studies may include very heterogeneous patient populations and the items included for preference assessment can vary greatly from study to study. We noticed that there are a few reviews using tables to summarize the preference rankings of the attributes obtained within each study, which helps authors better communicate with readers [29, 36]. Perhaps statistics such as the frequency of an item being ranked as most important could be used as a measure in meta-analysis to synthesize preference data. We need more statisticians and methodologists in this field to develop novel approaches to doing meta-analysis in preference research.

A reporting guideline for patient preference studies is likely to substantially improve the reporting of such studies. We found that systematic reviewers in our survey often needed to include terms such as “utility,” “attitude,” “expectation,” “willingness,” “satisfaction,” and “value” to capture relevant publications, indicating that the definitions and terms used by most investigators for patient preferences may be at present quite inconsistent. Additionally, in several reviews we found that their included studies did not refer to themselves as the specific design for preference-eliciting research (such as visual analogue scale, time trade-off, or discrete choice experiment); instead the investigators described the studies as a cross-sectional survey or patient questionnaire research, which made it more difficult for systematic reviewers to conduct the search. Reviewers rely heavily on the reporting of published articles to perform assessment and synthesis of studies. Only if there is a complete, clear and transparent reporting of the original articles can most systematic reviewer conduct proper evidence synthesis [43]. Similar to having other reporting guidelines, having a guideline on reporting of patient preference studies may indirectly improve the design and conduct of the primary studies as well. We hope in the near future that such guidance is available to investigators aiming to embark on patient preference research.

The major limitation of this work is that we did not conduct a complete systematic review of reviews. We are somewhat limited in our search of the literature since we did not perform the search beyond the PubMed database, did not explode our search terms extensively, and did not search for non-English publications. This could have made us miss some high-quality systematic reviews—although this is not likely to be the case.

Conclusion

Our survey of the literature demonstrates that there is a strong interest in the healthcare field in conducting research on patient preferences and also on performing systematic reviews of patient preference studies. However, our survey also reveals that there is still room for improvement of the reporting of patient preference studies. Likewise, many methodologies used to perform systematic reviews of these studies need to be tested and refined by researchers as well. In particular, research community should develop research agenda to inform systematic reviewers working on patient preferences of the search for studies, quality assessment of studies, synthesis of studies and reporting of reviews.

Acknowledgments

We thank Ms. Yu-Lin Huang for her help on data extraction.

Funding

Funding was partly provided by the Ministry of Science and Technology, Taiwan (grant number MOST 106–2314-B-039-001) and China Medical University, Taiwan (grant number CMU106-N-17).

Availability of data and materials

Data analyzed in this study are available upon request.

Authors’ contributions

Authors’ contributions

TY conceived the study idea and drafted the manuscript with support from NEA and GZ. All authors conducted the data extraction. All authors contributed to the interpretation of the results, and reviewed and approved the final manuscript.

Notes

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Tsung Yu, Phone: 886-4-22053366, moc.liamg@umc.uy.gnust.

Nomin Enkh-Amgalan, moc.oohay@0170_nimon.

Ganchimeg Zorigt, moc.oohay@tgiroz_gemihcnag.

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