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Sci Rep. 2017; 7: 17058.
Published online 2017 December 6. doi:  10.1038/s41598-017-16415-0
PMCID: PMC5719020

Entropic patchiness drives multi-phase coexistence in discotic colloid–depletant mixtures

Abstract

Entropy–driven equilibrium phase behaviour of hard particle dispersions can be understood from excluded volume arguments only. While monodisperse hard spheres only exhibit a fluid–solid phase transition, anisotropic hard particles such as rods, discs, cuboids or boards exhibit various multi–phase equilibria. Ordering of such anisotropic particles increases the free volume entropy by reducing the excluded volume between them. The addition of depletants gives rise to an entropic patchiness represented by orientation–dependent attractions resulting in non–trivial phase behaviour. We show that free volume theory is a simple, generic and tractable framework that enables to incorporate these effects and rationalise various experimental findings. Plate-shaped particles constitute the main building blocks of clays, asphaltenes and chromonic liquid crystals that find widespread use in the food, cosmetics and oil industry. We demonstrate that mixtures of platelets and ideal depletants exhibit a strikingly rich phase behaviour containing several types of three–phase coexistence areas and even a quadruple region with four coexisting phases.

Introduction

In the beginning of the 20th century Jean Perrin1 showed that colloids behave as large atoms in terms of their statistical thermodynamic properties. As a consequence, this analogy also holds for their phase behaviour2: spherical atoms or molecules assume vapour, liquid and solid phase states just as colloidal spheres in a background solvent. The phase behaviour of molecules and colloids depends on the effective interactions between them. The particles typically repel each other at short distances due to excluded volume interaction and may attract one another at larger distances. What makes colloids interesting with respect to molecular systems is that the range and strength of the colloidal interactions as well as colloidal shapes are tuneable3. At the end of the last century it became possible to prepare colloidal dispersions with particles that only interact via a hard–core repulsion4. For a collection of sufficiently monodisperse colloidal hard spheres the equilibrium phase diagram is a simple one: below a volume fraction of 49% the dispersion is fluidic and above 55 vol% it assumes a face–centred cubic crystalline solid phase5,6. This is the most elementary manifestation of an entropy–driven phase transition; it is driven by repulsive (excluded-volume) interactions alone.

Phase transitions in systems of hard colloids with anisotropic shapes typically occur at smaller concentrations. In a seminal paper Onsager7 argued that a suspension of thin hard rods of length L and diameter D undergoes an isotropic–nematic phase transition when the volume fraction of rods is of order D/L. Although the rods are orientationally disordered in the isotropic phase and ordered in the nematic phase, the excluded volume interaction between the rods, which scales with L 2 D, is smaller in the nematic phase: the available space for a rod increases as the rods align8. This is a key thermodynamic property of hard core particles (HCPs): above a certain concentration the entropy increase due to a gain in free volume per particle compensates the orientational entropy loss as the density is not uniform in orientation or position. Free volume entropy also explains the phase transition of long rods from a nematic towards a smectic phase911 as well as the liquid crystalline phases encountered in dispersions of platelets1214 or boards1517. In view of their additional orientational degrees of freedom particles with an anisotropic hard core18,19 exhibit a much richer phase behaviour than their spherical counterparts. Nowadays this phenomenon is usually referred to as shape entropy 20.

Adding depletants such as nonadsorbing polymers (or nonadsorbing colloidal particles) to a dispersion of hard–core particles enables a systematic control of the attractions between the HCPs with tunable strength (amount of depletants) and/or range (depletant size) of the attraction21, as was rationalised first by Asakura and Oosawa22. The depletion effect originates from the excluded volume between the colloidal particles and the depletants2326. While all direct interactions are repulsive, an effective entropy–induced attraction mediated indirectly via the depletants supplements the direct hard–core repulsion between the colloids. Even for simple hard spheres the addition of depletants significantly enriches the phase behaviour of the pure hard sphere dispersion: for small depletants (short–range attraction; depletant radius δ  ≲  1/3 of the sphere radius a) it broadens the fluid–crystal coexistence region and for sufficiently long–ranged attractions, q = δ/a  ≳  1/3, a colloidal gas–liquid phase coexistence region appears25,2729. Besides the isostructural fluid–fluid coexistence an isostructural solid–solid phase transition can be induced by adding tiny hard spherical depletants to an ensemble of bigger hard spheres30,31. The addition of depletants imparts a tunable attraction that dramatically modifies the phase behaviour of hard–sphere suspensions.

Intriguingly, in case of anisotropic particles, the depletion attraction becomes inherently orientation–dependent. A better understanding of the consequences of the depletant–mediated entropic patchiness of hard rod- and plate-shaped colloids on their phase behaviour32 remains an important issue both from a fundamental scientific standpoint as well in view of many technological applications involving composite lyotropic liquid crystals. We limit our scope to the most emblematic anisotropic colloidal shapes20,33, namely uniaxial rods and platelets, and discuss a selection of experimental and theoretical observations of liquid crystal phase ordering. For hard rods plus depletants adding nonadsorbing polymers tunes the phase behaviour as follows. For small depletants, δ  ≲  D, the isotropic–nematic (I–N) coexistence region is not affected much, but within the nematic branch there is a possibility of coexistence between two different (isostructural) nematic phases (N–N)21,34,35. At higher rod concentrations a phase with long–ranged uni–dimensional periodic order called a lamellar or smectic (Sm) phase appears911 and there is a nematic–smectic phase coexistence region. At sufficiently large depletant concentrations this opens up the possibility of three–phase (I–N–Sm) coexistence36. It may be that N–N coexistence is in practice often superseeded by the appearance of smectic phases21. For somewhat larger depletants (δ ~ D for 10  ≲  L/D  ≲  100) the addition of nonadsorbing polymers mainly broadens the I–N coexistence region, while N–N coexistence becomes metastable. Experimentally, the broadening of the I–N coexistence upon adding depletants in rodlike dispersions is well known, see for instance37,38. For large depletants the possibility of coexistence between a dilute isotropic and denser isotropic phase (I–I coexistence) appears. In such a case the effective attractions become long–ranged to such a degree that parallel alignment of the rods is not specifically preferred anymore. Theory also predicts several remarkable triphasic I–I–N and I–N–N coexistence regions for certain combinations of L/D and size of the depletants35. Three–phase I–I–N coexistence has been observed experimentally in mixtures of rods plus nonadsorbing polymers39,40 and I–N–N coexistence was detected in mixtures of rodlike virus particle suspensions41.

The focus in this communication is on developing a simple thermodynamic theory for dispersions of hard platelets plus nonadsorbing polymers, see Fig. 1. Plate-shaped colloids play a key role in certain biological processes (such as the clustering of red blood cells21) as well as constitute a major component of various food and cosmetic products. We explore the phase behaviour of such dispersions and make use of the fact that accurate analytical free energy expressions are available for the fluidic isotropic, nematic and columnar phases of hard discs13. While a similar theoretical analysis would in principle be possible for rod-depletant mixtures, such an undertaking is severely hampered by the lack of quantitatively reliable information for the thermodynamics of the lamellar phase and we do not further consider the consequences of entropic patchiness due to rod-shaped objects in the rest of our study. Further motivation to focus on plate-depletant mixtures stems from several important observations of multiphase coexistences reported in experimental studies of platelets plus nonadsorbing polymer chains42,43 and other types of depletants4446. We show that many of these phase diagram scenarios can be rationalized using a tractable and generic statistical thermodynamic theory based on simple free-volume concepts21,27,47 that we will briefly expound below.

Figure 1
Snapshot of an isotropic (I), nematic (N) and columnar (C) phase composed of (red) hard plates with diameter d and thickness t mixed with nonadsorbing polymers (green coils) embedded in a continuum background solvent. In free-volume theory (FVT) the polymer ...

Results and Discussion

Free volume theory (FVT) is used here because it is simple, insightful and fairly accurate. The system of interest contains colloidal platelets, polymer chains and a background solvent in a volume V. The platelets are described as hard uniaxial, cylindrical discs having a volume vcπtd2/4, with diameter d and thickness t. The geometry of the system of discs and polymer chains can be described using two dimensionless size ratios Λ = t/d and q = 2δ/d. Within FVT the system of interest is held in equilibrium with a reservoir that only contains polymer chains and background solvent. A hypothetical semi–permeable membrane that connects the system and reservoir compartments is permeable for polymer chains and solvent but impermeable for the colloidal platelets. In order to describe the thermodynamic properties we consider the (dimensionless) grand potential Ω quantifying the thermodynamic state of a mixture of hard platelets plus polymers in a background solvent. For such a system an exact thermodynamic expression can be derived21,48,49, namely Ωn=Fnvcvd0ϕdRαn(ΠdR/ϕdR')dϕdR', featuring the (normalised) Helmholtz free energy F, reservoir osmotic pressure ΠdR and the relative depletant concentration ϕdR. We define the thermal energy kBT (with k B Boltzmann’s constant) as the unit of energy, and for convinience we multiplied all energies by the volume of one hard platelet over the total volume of the system21. The sub–index n refers to the different liquid crystalline phases considered. The quantity ϕdR defines the relative polymer concentration which is implicitly normalised by the coil overlap concentration, whereas the depletant volume vd = 4πδ3/3 is used to render the osmotic pressure dimensionless. Further α n defines the free volume fraction available for the depletants in the system. It should be noted that α n is derived specifically for each phase state (isotropic, nematic and columnar) considered, see its definition in the Methods section.

Since the polymer concentrations needed to induce phase transitions are far below the polymer overlap concentration the polymers are treated as ideal chains which can be described well in terms of penetrable hard spheres50 with respect to depletion–mediated interactions51,52. Penetrable hard spheres, with a radius δ that equals the effective depletion thickness, experience a hard interaction with the (hard) colloidal platelets but do not interact with each other, see Fig. 1. This implies ΠdR can be simplified using Van ‘t Hoff’s law: ΠdR=ϕdR. A reliable approximation for the free volume fraction can be obtained using scaled particle theory21. Assuming that the free volume corresponds to that of a polymer-free suspension of hard platelets, the dimensionless grand potential is given by

Ωn=FnvcvdαnΠdR.
1

In order to make progress we require accurate expressions for the Helmholtz energy F n for platelets in the different liquid crystalline phases. We consider isotropic, nematic and columnar phases of hard discs, for which accurate expressions were derived13, see Methods.

The phase behaviour of pure platelets can be computed from standard thermodynamics (equality of chemical potential and osmotic pressure in each of the coexisting phases; see Methods) from the free energy expressions (see Methods) of Eqs (2), (3) and (4) and it has been demonstrated13 that these are close to Monte Carlo computer simulation results13. The isotropic–nematic (I–N), isotropic–columnar (I–C) and nematic–columnar (N–C) coexistences are plotted in Fig. 2 as the light grey curves (marked by the texts I–N, N–C and I–C in between coexisting curves); coloured curves will be discussed later on. Starting from the limit of infinitely thin plates (Λ→0) the volume fractions η for a suspension of discs at N–C coexistence hardly varies with increasing Λ. In contrast the I–N coexistence volume fractions strongly increase with increasing Λ until they merge with the N–C coexistence at Λ  0.16, beyond which the nematic region ceases to exist and only I–C coexistence survives for Λ  ≳   0.16.

Figure 2
Multi–phase coexistence {η, Λ} contour plot for indicative relative polymer sizes (q) as indicated compared to the phase diagram of a pure platelet suspension (gray solid curves). At {Λ,q}{0.12,0.16} (black dot), a quadruple I–I–N–C ...

Next, we study the influence of added depletants on the phase behaviour using Eq. (1), from which the chemical potential of the discs and osmotic pressure of the mixture can be computed at a given depletant reservoir concentration ϕdR. Earlier computer simulations53, combined computer simulation plus free volume theory approaches5355 and fundamental measure theory56 have hinted at the richness of the phase behaviour. In Fig. 3 (left panel) we have redrawn the hybrid approach of Monte Carlo computer simulation and theory results by Zhang, Reynolds and van Duijneveldt54 in terms of the fugacity z (=6ϕdR/[πq3]) versus platelet concentration Nd3/V = 4η/(πΛ), with N the number of platelets in the system of volume V. At zero depletant concentration (z = 0) the I–N and N–C coexistences of pure hard platelets are recovered. Upon increasing the depletant concentration (higher z values) the I–N coexistence slowly widens until an I–I–N triple line appears. At relatively small platelet concentrations there is coexistence between two isotropic fluid phases (I–I). Such an isostructural coexistence region has been reported recently by Chen et al. 45 for aqueous suspensions of Zirconium phosphate platelets with added (very dilute) silica spheres as depletants. At higher z values the N–C coexistence also widens a bit until it hits an I–N–C triple line. The hybrid computer simulation–theory results are (Fig. 3; left panel) qualitatively reproduced by our theoretical free volume calculations (Fig. 3; right panel). The correspondence of Fig. 3 benchmarks our FVT approach. In the S.I. a comparison is also shown at another relative depletant size q.

Figure 3
Comparison of computed phase diagrams for a mixtures of colloidal platelets plus nonadsorbing polymers (simplified as mutually penetrable hard spheres) for Λ = 0.1 and q = 0.2. Left: hybrid approach of free volume ...

A major advantage of FVT is that it enables a facile and systematic exploration of the various possible phase states and coexistences by variation of the relative depletant size (q) and relative platelet thickness (Λ). An example is given in Fig. 4 for q = 0.215 upon varying Λ from 0.145 to 0.155, both in terms of the reservoir depletant concentration (upper panels) along the ordinate (as in Fig. 3) as well as for the system depletant concentrations (lower panels). The depletant concentration in the system follows from the reservoir concentration as ϕdS=αnϕdR. At Λ = 0.145 (upper left panel) we find a similar situation as in Fig. 3 but with the two triple lines (I–I–N and I–N–C) close to each other. In the lower panel it is shown that these triple lines become triple regions (coloured orange and red, respectively) when the depletant concentration in the system is considered, as was similarly demonstrated for hard spheres or rods plus depletants27,34. The transition from a triple line to a triple region originates from the partitioning of the depletants over the coexisting phases, a key effect borne out by FVT. For Λ = 0.155 (upper right panel) the two triple lines have crossed; the I–I–N triple line now has become an I–I–C triple line and the I–N–C line has dropped to lower depletant concentration ϕdR. As a result, at the transition point at Λ = 0.150 (middle upper panel) a quadruple I–I–N–C coexistence appears. In the system representations (lower panels) the four–phase coexistence line becomes a quadruple region. Such four–phase coexistence was reported experimentally for a mixture of sterically stabilised gibbsite platelets mixed with polydimethylsiloxane (PDMS) polymer chains in toluene42, but was not yet predicted by theory or simulation. The detected four–phase region was assigned by the authors to polydispersity effects. Using FVT we can rationalise such a four–phase coexistence in a platelet plus depletant mixture without the need to take into account polydispersity effects or sedimentation57. In a different system of aqueous dispersions of rather polydisperse positively charged Mg2Al layered double hydroxide platelets mixed with polyvinyl pyrrolidone polymers, Luan et al. 43 also reported four–phase coexistence. These experimental examples corroborate the possibility of the quadruple region reported in this study.

Figure 4
Collection of phase diagrams in the {η,ϕdR} (top panels; reservoir representation) and {η,ϕdS} (lower panels) phase spaces for hard platelets plus added depletants at q = 0.215 as a function of aspect ratio ...

We return to Fig. 2 where, besides the phase coexistence regions of hard platelets (gray, solid curves), also contour plots have been added for various depletant sizes, expressed via q. Each solid coloured curve corresponds to a triple coexistence (I–I–N or I–I–C), while dashed curves correspond to the two possible I–N–C triple coexistences (above or below the I–I containing triple point, see Fig. 4). Hence we find a plethora of different triple lines. When the two solid curves collapse, an I–I–N–C quadruple line is found (solid black curve). Hence, all solid coloured curves to the left of the quadruple curve correspond to I–I–C coexistences, whereas the ones on the right correspond to I–I–N triple lines. As expected, the I–N–C triple lines also collapses to the quadruple line. All triple point curves run from the quadruple line to the depletant–free limit with increasing q, and indicates the dramatic effect of depletion–mediated attraction between the discs. The solid, black, dashed curves are the triple I–I–N and I–I–C end point regions: they mark the points at which the I–I critical point matches with the I–I–N or I–I–C triple point. Hence, the black curves correspond to the points where the two I–I–N or I–I–C triple point branches collapse. The location at which the critical I–I–N end point curves match with the critical I–I–C end points defines the I–I part of the critical end point of the quadruple (big black dot), which acts here as reference point for all other curves. Finally, the two long–dashed vertical curves correspond to the triple point I–N–C for platelets in the absence of depletants and to the quadruple critical end point for colloidal platelet–polymer mixtures. This indicates that the isotropic–columnar coexistence occurs at lower Λ due to the addition of depletants.

Fundamental insight into multi-phase coexistence is of considerable scientific relevance in view of a range of applications where fluid stability and homogeneity needs to be guaranteed or it can be explored to optimize particle size fractionation and purify colloidal composite materials in an efficient, sustainable and low-cost manner58, thereby circumventing energy consuming separation technology. Regions where multiple phases coexist are of relevance for developing switchable or multistable materials5961 whose properties change upon applying an external mechanical or electro-magnetic field. Last not least, a detailed understanding of the phase behaviour of colloid–polymer mixtures is important for the development of photovoltaic cells62 and polymer–based solar cells63.

In this communication we have shown that shape entropy is an emergent property that leads to a rich phase behaviour of mixtures of hard discs plus nonadsorbing polymers including a wide range of triple coexistences and a quadruple region, hitherto unexplored by theory or simulation. The findings derived from free volume theory (FVT) for discs plus depletants are supported by experiments and are in line with numerical Monte Carlo computer simulation–theory data.

Free Volume Theory offers an efficient and versatile tool to systematically explore parameter phase space, spanned by the colloid aspect ratio and colloid-depletant size ratio, and scrutinize various phase behaviour scenarios that may subsequently serve as useful benchmarks for more in-depth experimental and simulation explorations. FVT reveals those phase space regions where specific phase coexistences may be found in experimental work or computer simulation studies.

We have demonstrated that free-volume theory (FVT) enables a simple, tractable and insightful analysis of the phase behaviour of colloid–polymer mixtures while maintaining accurate predictions on the semi–quantitative level with only two size ratios as system input parameters. Since FVT captures the essential physics of depletion-mediated entropic patchiness of simple rod- or disk-shaped building blocks, the predictions are expected to be qualitatively fully equivalent to those emerging from more accurate but technically more demanding treatments. Future efforts will be directed towards gaining a deeper understanding of isostructural I–N–N triple equilibria that have been reported experimentally in mixtures of platelets plus depletants43,44. Other types of triple and quadruple phase-coexistences involving several fluid and liquid crystalline phases with distinctly different symmetries will be investigated as well.

Methods

Free energy expressions of hard discs

For the isotropic state the volume fraction (η) dependence of the (dimensionless) excess free energy of an isotropic ensemble of cylindrical hard discs can be written as13:

FI=2πη2ΛGΘI(Λ),
2

where G=(43η)/(4[1η]2) is a virial renormalization approximation proposed by Parsons65 and Lee66 for virial coefficients beyond the pair level. We omit the ideal contribution, cnst × ηηlnη − η, in all free energies. The normalised ensemble averaged excluded volume in the isotropic phase is given by:

ΘI=π28+(3π4+π24)Λ+πΛ22.

In the nematic state one should account for the alignment of the hard platelets. The orientational distribution function (ODF), describing the orientational probability of the plate normals with respect to the nematic director is assumed to be a simple Gaussian67,68,  ∼ (κ/4π)exp[−κθ2/2]. The ODF only depends on the polar angle θ between two rods21. Hence one arrives at:

FNη=σN+2πηΛGΘN,
3

with κ=πη2G2/(4Λ), a variational parameter indicating the degree of nematic alignment as follows from minimizing the free energy with respect to the ODF. The free energy Eq. 3 now includes a rotational entropy term σN = lnκ − 1 and a normalised excluded volume:

ΘN=12π3/2κ1/2+2πΛ.

For the columnar phase, cell theory69 pre-supposes the disc columns to accommodate a single–occupancy bidimensional hexagonal lattice while the discs experience strictly uni-dimensional intracolumnar fluid order with asymptotically weak orientational freedom. A major advantage of this approach is that it yields a closed expression for the free energy13:

FCη=2ln(11ΔC)+2ln(3ΔC2ϕ2Λ(1ΔC2ϕ))ln(13ΔC2ϕ3)2
4

with ΔC=[23K2/3334ϕ]/[62/3K3ϕ] and K=3ϕ⁎3(243ϕ+32)+27ϕ⁎2, where ϕη/ηcp, with ηcp the closest packing fraction of columnar discs70 ηcp=π3/60.907.

Free volume fraction for depletants in a suspension of hard platelets

In order to compute the grand potential from Eq. (1) we need the free volume fraction of depletants in the pure platelet suspension. This can be derived from scaled particle theory21 and yields:

αn=(1η)exp[Q]exp[vdvcΠno],
5

in which v d is the depletant volume. The osmotic pressure of the depletant-free system Πno can be computed from the free energy of the phase state (isotropic, nematic, columnar) under consideration, with F n given in the previous subsection. The quantity Q corresponds to a shape-dependent immersion free energy term for inserting depletants into the colloidal dispersion and reads:

Q=q(1Λ+πq2Λ+q+2)y(η)+2q2(14Λ2+1Λ+1)[y(η)]2,

with

y(η)=η1η.

Phase coexistence calculations

Coexistence between different phases is established if the chemical potentials of the platelets μ and osmotic pressures of the platelet–depletant mixtures Π are equal in those phases:

Πi = Πj , and μiμj
6

where the subscripts {ij} denote the possible states of the system: isotropic (I), nematic (N), or columnar (C).

The chemical potential and osmotic pressure can be calculated from the grand potential in Eq. (1) using

μn=(Ωnη)T,V,NdRandΠn=ημnΩn,
7

where NdR is the number of depletants in the reservoir of volume V.

An isostructural phase coexistence of two phases with the same symmetry is characterized by a critical point, which can be calculated from the conditions:

(μnη)T,V,NdR=(2μnη2)T,V,NdR=0.
8

Three phases coexist when the following condition is met:

Πi = Πj = Πm , and μiμjμm
9

where m is a certain phase identity (I, N or C). Likewise, a four-phase coexistence naturally follows from the condition:

Πi = Πj = Πm = Πn , and μiμjμmμn
10

where n is a certain phase state, where two of the four coexisting phases have the same phase state.

Data availability

The data that support the findings of this work are available from the corresponding authors upon request. We can also provide Wolfram Mathematica files that were prepared to calculate the phase diagrams.

Electronic supplementary material

Acknowledgements

R.T. and A.G.G. acknowledge the Netherlands Organization for Scientific Research (NWO TA Grant No. 731.015.025) for financial support. We are grateful to A.V. Petukhov for his useful comments on the manuscript and thank J.V. Maring for initial computations.

Author Contributions

Author Contributions

R.T. and H.N.W.L. proposed and supervised the study, A.G.G. derived the details of the theoretical approach and performed the calculations. H.H.W. suggested to incorporate the columnar phase. All authors wrote the manuscript and discussed the results and contributed to the iterations of the manuscript.

Notes

Competing Interests

The authors declare that they have no competing interests.

Footnotes

Electronic supplementary material

Supplementary information accompanies this paper at 10.1038/s41598-017-16415-0.

Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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