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Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers.
Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approaches in this category of patients in which the detection of melanoma can be difficult because of the presence of multiple skin tumors.
A 71-year-old Caucasian man with neurofibromatosis type 1 (NF1) attended our skin cancer clinic for routine dermato-oncologic follow up of primary multiple minimal invasive melanomas (melanoma stage IA) diagnosed during the past eight years.
Physical examination revealed the presence of numerous neurofibromas and café au lait spots on his trunk and limbs, as well as axillary freckles. In addition, a light brown nodule with a pinkish halo of 8 mm in diameter was noticed at the left lumbar region (Figures 1, ,2).2). Although this lesion was clinically unremarkable, it differed somehow from the surrounding other nodules (i.e., revealing the so-called “little red riding hood sign”) . Upon dermoscopy, the central nodular part revealed brown-gray rhomboidal lines and white lines, whereas the pink halo exhibited small diameter, polymorphic microvessels and white crossing lines (Figure 3). Based on the dermoscopic appearance, as well as on the history of multiple primary melanomas, a clinical diagnosis of melanoma was suspected. The lesion was subsequently excised. Histopathological evaluation confirmed the clinical suspect of a focally regressive invasive melanoma (Breslow thickness 1.05 mm, pT2a). Imaging staging examinations revealed no evidence for metastases. The patient is currently scheduled for wide local excision and sentinel node biopsy.
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder resulting from a mutation in or a deletion of the NF1 tumor suppressor gene on the long (q) arm of chromosome 17 that encodes a protein named neurofibromin 1 . A mutated form of the latter leads to a predisposition for malignant neoplasms, most commonly derived from the neural crest . Melanocytes are derived from embryologic neural crest, so these patients can develop malignant melanocytic proliferations [2,3]. Although several sporadic cases of patients with NF1 associated with melanoma have been reported in literature, the relationship between NF1 and melanoma is still a matter of debate .
Our case supports such an association, given that our patient suffered from seven multiple primary melanomas. Moreover, our case highlights the benefit of the comparative approach in patients with multiple skin tumors, as the melanoma in our patient, albeit not evident, differed from the surrounding neurofibromas . Finally, dermoscopy pointed towards the correct diagnosis of hypo- and amelanotic melanoma by allowing the visualization of melanoma-specific features such as brown-gray lines, white lines and polymorphic vessels. Until future research reveals new insights into a potential common pathogenesis of NF1 and melanoma, we propose close follow-up dermatological visits of patients affected by NF1.
Competing interests: The authors have no conflicts of interest to disclose.
All authors have contributed significantly to this publication.