|Home | About | Journals | Submit | Contact Us | Français|
In a study by Sow et al. (e00265-17), Malian adults were randomly allocated to receive a single standard dose (108 CFU) or a high dose (109 CFU) of CVD 103-HgR live oral cholera vaccine or two doses (2 weeks apart) of Shanchol killed oral cholera vaccine. Inaba serum vibriocidal antibody responses (seroconversion rate, geometric mean titer [GMT], and fold rise) were compared. High-dose CVD 103-HgR exhibited significantly higher seroconversion rates than one or two doses of Shanchol and significantly higher GMTs than standard-dose CVD 103-HgR. A single high dose of CVD 103-HgR is recommended for accelerated evaluation in developing countries to assess effectiveness and practicality in field situations.