Search tips
Search criteria 


Logo of annrcseLink to Publisher's site
Ann R Coll Surg Engl. 2010 March; 92(2): e32–e34.
Published online 2010 March. doi:  10.1308/147870810X476773
PMCID: PMC5696906

Unusual cause of acute abdomen – omental infarction occurring in a child with cyclical neutropenia


Omental infarction is a rare cause of acute abdomen in childhood. We describe a case of omental infarction mimicking acute appendicitis occurring in a child with cyclical neutropenia. Neutropenic enterocolitis, a serious cause of the acute abdomen, has been linked with cyclical neutropenia. In neutropenic patients, omental infarction when diagnosed pre-operatively can be managed conservatively with the focus on improving the neutrophil count. If after imaging the diagnosis is in doubt, there should be a low threshold for laparoscopy. The low incidence of omental infarction will continue to mean that it is a diagnosis made at operation for suspected appendicitis. In these cases, the infarcted tissue may be removed by the laparoscopic or open technique.

Keywords: Omental infarction, Acute abdomen, Appendicitis, Neutropenia

Case report

A 16-year-old boy presented with a 24-h history of constant right iliac fossa pain. On examination, he was 154.6 cm tall (0.4th centile) and weighed 73.4 kg (91st centile), and his body mass index (BMI) was 30.6 kg/m2 (99th centile). Temperature was normal. On abdominal examination, tenderness and guarding were evident in the right iliac fossa. Clinical diagnosis was acute appendicitis.

This patient had history of cyclical neutropenia, a rare haematological condition in which neutropenia develops every 3–4 weeks. The neutropenia is often accompanied by pharyngitis, acute otitis media and apthous stomatitis. The condition was diagnosed at the age of 11 years by twice weekly serial differential blood counts over a 2-month period. A bone marrow biopsy was normal and anti-karyotype and anti-lymphocyte antibodies were negative. Treatment is with granulocyte-colony stimulating factor (G-CSF; 262 μg) four times a week which, although not eliminating the cyclical neutropenia, reduces its extent and hence the accompanying infections.

On admission, the neutrophil count was 1.82 × 109 cells/l. Pre-operatively, the patient was given a dose of G-CSF after discussion with the haematologist. At open operation, a normal retrocaecal appendix was removed and a 5-cm focal patch of necrosed omentum was excised (Fig. 1). Histopathology confirmed a normal appendix and omentum with focal fat necrosis. Postoperative recovery was uneventful and he was discharged 2 days later after liaison with the haematologist.

Figure 1
Infarcted omentum.


Omental infarction is a rare cause of acute abdomen in children.1 It is rarely diagnosed pre-operatively due to its low incidence and convincing mimicry of acute appendicitis. Indeed, most cases reported in the literature, as in our case, are diagnosed at operation for suspected appendicitis. Cyclical neutropenia is a rare haematological disorder characterised by periodic oscillations in the peripheral neutrophil count.2 Patients have a tendency to minor infections and ulcerative stomatitis, and rarely have overwhelming sepsis.3 Neutropenic enterocolitis, a serious cause of acute abdomen, has been linked with cyclical neutropenia46 and is associated with a high mortality.6 However, an extensive literature search did not reveal any reported cases of omental infarction in a child with cyclical neutropenia.

Omental infarction and omental torsion, two similar conditions, are classified as separate entities.7 Omental infarction is divided into primary and secondary. The infarction is termed primary when no cause can be found, while secondary infarction is associated with hyper-coagulable states, vasculitis and pancreatitis.8 Omental infarction occurs more commonly on the right half of the omentum. The distal right epiploic artery has been implicated in torsion and infarction occurring around the right gastrocolic ligament of the greater omentum. This tendency of the right side to infarct has been linked with anatomical variations of the omental pedicle, including bifid right omentum and increased mobility of that side.8

Despite being a rare condition, several risk factors have been identified. Obesity, as observed in our patient, is a recognised risk factor.8 It has been postulated that the increased fat deposition in the omentum of obese children outstrips the blood supply. Omental infarction may be differentiated from appendicitis, and importantly in the neutropenic patient, neutropenic enterocolitis, by the absence of gastrointestinal symptoms (including bloody diarrhoea in the case of neutropenic enterocolitis), fever, anorexia and a normal leukocyte count.4,8 If suspicion over a diagnosis remains, computed tomography has been shown to have a high sensitivity and specificity for diagnosis of omental infarction.9,10 Ultrasound provides a typical appearance of omental infarction of a hyperechoic, non-compressible mass adherent to the abdominal wall with overlying probe tenderness, although it is operator-dependent and has low sensitivity.11

When diagnosed pre-operatively by ultrasonography or computed tomography, omental infarction should be managed conservatively.10,12 However, the diagnosis of omental infarction is rarely made pre-operatively. Operative management in this case, open or laparoscopic, leads to rapid resolution of symptoms.1,8 The standard McBurney’s incision may be insufficient for diagnosis and resection as the infarcted tissue is often found in the right upper quadrant of the omentum; hence, laparoscopic surgery is recommended.1,8

It is common for paediatric surgeons to operate for suspected appendicitis on the basis of clinical examination rather than rely on pre-operative blood tests, and the neutrophil count may not be known at the time of operation. When a normal appendix is found at operation, the surgeon should actively seek out a cause for abdominal pain. This should include examining the right colon for signs of enterocolitis. In our case, the diagnosis of neutropenic omental infarction was made at the time of operation, so a trial of conservative management was not possible. When diagnosed pre-operatively, neutropenic omental infarction should be managed conservatively, with a focus in improving the neutrophil count with G-CSF, and supportive treatment with intravenous fluids and antibiotics. The management of neutropenic enterocolitis has been well described elsewhere.1317 Conservative management is again advocated in the first instance, with a focus on improving the neutrophil count, after which neutropenic enterocolitis frequently ameliorates. Surgical management is indicated in peritonitis, pneumoperitoneum, shock, bowel wall necrosis, haemorrhage, abscess formation and deterioration after conservative management.17,18 In neutropenic patients where imaging has been equivocal, laparoscopy has been recommended.12


This case highlights the rare condition of omental infarction and, to the authors’ knowledge, the only case occurring in a child with cyclical neutropenia. Judicious use of imaging makes a pre-operative diagnosis of omental infarction possible, allowing conservative management in the first instance. Neutropenic enterocolitis has also been linked with cyclical neutropenia. The literature currently advocates conservative management for neutropenic patients with an acute abdomen. However, there are specific indications for surgical intervention including perforation, abscess formation, peritonitis and failed medical management. When the diagnosis after imaging in the neutropenic patient is in doubt, laparoscopy should be considered. In the absence of pre-operative blood tests and a normal appendix at operation, the surgeon should always seek to exclude neutropenic enterocolitis. The low incidence of omental infarction will continue to mean that it is a diagnosis made at operation for suspected appendicitis. In these cases, the infarcted tissue may be removed by the laparoscopic or open technique.


1. Loh May Han, Chui Chan Hon, Yap Te-Lu Omental infarction – a mimicker of acute appendicitis in children. J Pediatr Surg 2005; : 1224–6. [PubMed]
2. Hearn T, Haurie C Cyclical neutropenia and the peripheral control of white blood cell production. J Theor Biol 1998; : 167–81. [PubMed]
3. Bandason C, Lee RJ Fatal human cyclical neutropenia with unresolving tonsillitis and bilateral cercival abscesses. J Laryngol Otol 1991; : 487–8. [PubMed]
4. Geelhoed MD, Kane MA Colon ulceration and perforation in cyclic neutropenia. J Pediatr Surg 1973; : 379–82. [PubMed]
5. O’Hanrahan T, Dark MB Cyclic neutropenia – unusual cause of acute abdomen. Dis Colon Rectum 1991; : 1125–7. [PubMed]
6. Kunkel JM, Rosenthal MD Management of ileocecal syndrome. Dis Colon Rectum 1986; : 196–9. [PubMed]
7. Kimber CP, Westmore P, Huston JM Primary omental torsion. J Pediatr Child Health 1996; : 22–4.
8. Varjavandi V, Lessin M, Kooros K Omental infarction: risk factors in children. J Pediatr Surg 2003; : 233–5. [PubMed]
9. Pereira ZM, Sirlin CB, Pinto PS, Jeffrey RB, Stella DL, Casola G Disproportionate fat stranding: a helpful sign in patients with acute abdominal pain. Radiographics 2004; : 703–15. [PubMed]
10. Coulier B. Segmental omental infarction in childhood: a typical case diagnosed by CT allowing successful conservative management. Pediatr Radiol 2006; : 141–3. [PubMed]
11. Schlesinger AE, Dorfman SR, Braverman RM Sonographic appearances of omental infarction in children. Pediatr Radiol 1999; : 598–601. [PubMed]
12. Fragoso AC, Pereira JM, Estevao-Costa J Nonoperative management of omental infarction: a case report in a child. J Pediatr Surg 2006; : 1777–9. [PubMed]
13. Urbach DR, Rotstein OD Thyphlitis. CanJ Surg 1999; : 415–9. [PMC free article] [PubMed]
14. Badgwell B, Cormier J, Wray C, Borthakur G, Qiao W, Rolston K et al. Challenges in surgical management of abdominal pain in the neutropenic cancer patient. Ann Surg 2008; : 104–9. [PubMed]
15. Bagnoli P, Castagna L, Cozzaglio L, Rossetti C, Quagliuolo V, Zago M et al. Neutropenic enterocolitis: is there a right timing for surgery? Assessment of a clinical case. Tumori 2007; : 609–10. [PubMed]
16. Picardi M, Camera A, Pane F, Rotoli B Improved management of neutropenic enterocolitis using early ultrasound scan and vigorous medical treatment. Clin Infect Dis 2007; : 403–4. [PubMed]
17. Alioglu B, Avci Z, Ozcay F, Arda S, Ozbek N Neutropenic enterocolitis in children with acute leukemia or aplastic anemia. Int J Hematol 2007; : 364–8. [PubMed]
18. Williams N, Scott AND Neutropenic colitis: a continuing surgical challenge. Br J Surg 1997; : 1200–5. [PubMed]

Articles from Annals of The Royal College of Surgeons of England are provided here courtesy of The Royal College of Surgeons of England