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ACG Case Rep J. 2017; 4: e117.
Published online 2017 November 8. doi:  10.14309/crj.2017.117
PMCID: PMC5679777

Paraneoplastic Hepatopathy Associated with Gastrointestinal Carcinoid


Paraneoplastic hepatopathy has been reported with various malignancies, most commonly with renal cell cancer. This non-metastatic hepatic dysfunction in such malignancies is known as Stauffer syndrome. We describe a 61-year-old man who presented with symptoms of bowel obstruction with marked cholestasis and high levels of alkaline phosphatase and bilirubin. Imaging revealed an unremarkable liver and a mass in the ileocecal valve with mesenteric lymphadenopathy. Biopsies were consistent with a carcinoid tumor. Liver dysfunction gradually resolved after surgical resection of the tumor. Paraneoplastic syndrome should be considered in the differential diagnosis for patients with carcinoid tumors who present with cholestasis.

Articles from ACG Case Reports Journal are provided here courtesy of American College of Gastroenterology