Search tips
Search criteria 


Logo of plosonePLoS OneView this ArticleSubmit to PLoSGet E-mail AlertsContact UsPublic Library of Science (PLoS)
PLoS One. 2017; 12(9): e0184442.
Published online 2017 September 13. doi:  10.1371/journal.pone.0184442
PMCID: PMC5597192

5-year long-term efficacy of 120-W GreenLight photoselective vaporization of the prostate for benign prostate hyperplasia

Juhyun Park, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing, Sung Yong Cho, Conceptualization, Data curation, Funding acquisition, Project administration, Writing – review & editing, Min Chul Cho, Data curation, Formal analysis, Methodology, Supervision, Hyeon Jeong, Data curation, Investigation, Project administration, Supervision, and Hwancheol Son, Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing*
Neal Shore, Editor



To investigate 5-year long-term postoperative efficacy in benign prostate hyperplasia (BPH) following 120-W GreenLight high-performance system photoselective vaporization of the prostate (HPS-PVP)


This was a retrospective study of surgical outcomes in 159 men who underwent HPS-PVP and were followed over 60 months postoperatively. Definitions of treatment success were established based on the following three variables: international prostate symptom scores (IPSS), maximum flow rates (Qmax), and quality of life scores QoL). Logistic regression analyses were performed to determine predictors of the postoperative success.


Postoperative IPSS/QoL, Qmax and post-voided residual urine volume were significantly improved after HPS-PVP. Postoperative Prostate specific antigen and prostate volume were also well reduced and sustained for 5 years. The postoperative success rate was assessed as 82.1%, 80.8% and 76.1% for each 1-, 3-, and 5-year. Thirty-eight (23.9%) patients had immediate postoperative complications, which were managed successfully with nonsurgical methods. None required transfusions, two (1.2%) patients required endoscopic reoperation for postoperative voiding difficulty due to bladder neck contracture or urethral stricture, and five (3.1%) required HPS-PVP reoperation. Presence of diabetes, voiding symptom subscore, QoL, maximal cystometric capacity, and bladder outlet obstructive index were valuable preoperative parameters for predicting postoperative success.


HPS-PVP is an effective, long-term treatment option for BPH, with sustained efficacy of 76.1% at 5-year follow up. Several preoperative parameters could help to predict the durable surgical improvements.


Benign prostatic hyperplasia (BPH) has been the main cause of low urinary tract symptoms in aging men and it was often associated with significant morbidity [1]. Recently, it has been known combination medical treatments using several type of drugs could achieve effective symptom improvements of BPH [2]. Nevertheless, surgical treatments should be selected primarily in the cases with refractory urinary retention, renal insufficiency, recurrent urinary tract infections, bladder stones or consistent prostate bleeding. In addition, when the medical treatments was not effective, surgery of BPH could be considered and weighed [3].

Transurethral prostatectomy (TURP) has long been accepted as the gold standard for the surgical treatment of BPH, and many clinicians have reported excellent short-term and long-term outcomes [4, 5]. However, TURP is associated with potential risks, including postoperative bleeding requiring transfusions, prolonged urethral Foley catheter indwelling, and transurethral syndrome [6]. To overcome these risks, alternative surgical procedures, including laser techniques, have been developed [710]. Laser technologies were first deployed in the early 1990s, Early-generation lasers could relieve bladder outlet obstruction due to BPH by utilizing coagulative and ablative modalities. Ablative techniques, such as GreenLight photoselective vaporization of the prostate (PVP), have remained popular.

The aim of GreenLight PVP is to make an unobstructed channel within the prostate, similar to TURP [11]. Because PVP was basically mimicking TURP, it had the advantage that urologists who had ever experienced TUR surgery could easily learn and practice PVP technique. The learning curves for GreenLight PVP were almost unnecessary [12]. Furthermore, by applying the wedge resection and enucleation technique, adventurous attempts to use GreenLight PVP even in the large size prostate [13, 14].

In recent years, Greenlight system with higher-energy lasers has been available, several expert groups published comparable or even better short-term and medium-term follow-up results using the GreenLight system than other BPH surgical modalities [15, 16]. However, long-term results obtained with the 120-W GreenLight high-performance system (HPS) have rarely been reported yet. Therefore, the aim of the present study was to investigate 5-year long-term surgical efficacy in BPH following 120-W GreenLight HPS-PVP and predictors of postoperative success.


The study consisted of 159 patients who underwent HPS-PVP for symptomatic BPH from January 2008 to March 2010 and were followed up for more than 5 years.

The indications for surgery were an International Prostate Symptom Score (IPSS) of 12 points or more before surgery and a maximal urinary flow rate (Qmax) lower than 15 ml/s, acute urinary tract obstruction, hydronephrosis or uremia, recurrent urinary tract infections due to excessive residual urine, bladder stones, and severe hematuria. The exclusion criteria were a neurogenic bladder in urodynamic studies, urethral stricture, previous prostate surgery, and prostate malignancy. Patients with incomplete preoperative and postoperative follow-up clinical information were also excluded. The study protocol was approved by the Institutional Review Board at Boramae Hospital, and the study conformed to the tenets of the Declaration of Helsinki.

All the patients underwent preoperative evaluations, including transrectal ultrasonography and multichannel video urodynamics (MMS UD-2000, Medical Measurement System, Enscheded, the Netherlands). Medical histories were taken to detect the presence of lower urinary tract symptoms suggestive of BPH, and all the patients underwent physical examinations. Data on age, serum prostate specific antigen (PSA), IPSS, quality of life (QoL), Qmax, postvoided residual urine volume (PVR), and urodynamic parameters, including the bladder outlet obstruction (BOO) index and bladder compliance, were recorded.[17, 18] In cases of prostate biopsies, these were performed preoperatively or intraoperatively via transrectal ultrasonography guidance. The same surgeon (H.S.) performed all the operations.

The HPS-PVP used in the study has been described in a previous study.[15] Perioperatively, the operative time, total amount of energy used (kJ), Foley catheter maintenance period, immediate complications, and the management of these were recorded. Postoperative complications were reported at every follow-up visit and classified according to the Clavien–Dindo system.

The following were assessed at the preoperative visit and at follow-visits 6, 12, 24, 36, 48, and 60 months after the surgery: IPSS/QoL, Qmax/PVR, prostate volume, and PSA. The presence of postoperative complications was verified at every follow-up visit.

In this study, definitions of treatment success were established based on the following three variables: IPSS, Qmax, and QoL.[19, 20] Overall efficacy was defined as the median efficacy grades from the symptoms, function, and QoL domains. Treatment success was defined if the overall efficacy demonstrated an improvement that was “fair or greater”. Univariate and multivariate logistic regression analyses were conducted to determine the predictors of a postoperative success at each 1-, 3-, and 5-year follow up.

Ethical standards

This study design and the use of patients’ information stored in the hospital database were approved by the institutional Review Board (IRB) at the Seoul Metropolitan Government—Seoul National University Boramae Medical Center. The approval number is 26-2016-123. We were given exemption from getting informed consents by the IRB because the present study is a retrospective study and personal identifiers were completely removed and the data were analyzed anonymously. Our study was conducted according to the ethical principles laid down in the 1964 Declaration of Helsinki and its later amendments.

Statistical analysis

Variables were presented as mean ± standard deviation. Comparing the pre- and postoperative clinical variables, an analysis of variance or a paired t-test and Wilcoxon’s signed-rank test were used. To evaluate predictors of sustained efficacy after HPS-PVP, logistic regression analysis was used. A P value of < 0.05 was considered statistically significant, and commercially available statistical software (SPSS 22.0, Chicago, IL) was used to analyze the data.


In total, 278 men underwent HPS-PVP during the study period. Of those, 159 (57.2%) patients with complete preoperative and postoperative follow-up clinical information were included and analyzed in this study.

The mean age of the subjects was 66.4 ± 7.1 years, and their mean body mass index was 24.1 ± 2.9 kg/m2. Twenty-one (13.2%) patients had diabetes mellitus, and 75 (47.2%) had hypertension. The preoperative mean PSA was 3.5 ± 4.5 ng/ml. The mean total prostate volume and transitional zone volume was 49.4 ± 32.6 ml and 29.9 ± 28.0 ml, respectively. The preoperative total IPSS was 18.9 ± 8.4, and the voiding symptom subscores and storage symptom subscores were 11.2 ± 5.5 and 7.7 ± 3.6 respectively. The QoL score was 4.0 ± 1.3. The preoperative mean Qmax was 10.0 ± 4.2 ml/s, and the preoperative mean PVR was 80.2 ± 79.7 ml. As shown by the preoperative urodynamic study, the mean maximal urethral closure pressure was 89.0 ± 28.0 cmH2O, and the maximum cystometric capacity was 408.3 ± 83.6 ml. Poor bladder compliance and involuntary detrusor contraction were present in 48 (30.2%) and 35 (22.0%) patients, respectively. The BOO index was 31.9 ± 27.3. The average operative time, energy used, and postoperative urethral catheter indwelling time were 67.4 ± 45.9 minutes, 89.6 ± 82.5 kJ and 24.5 ± 11.0 hours, respectively (Table 1).

Table 1
Preoperative and perioperative profiles of all patients.

The IPSS/QoL scores, and Qmax/PVR values were markedly improved from the 6-month follow-up and sustained during the course of the 5-year follow up. The reduction in the total prostate volume and transitional zone volume were also sustained after the surgery. The postoperative PSA level was significantly decreased and sustained lower than the preoperative level (Fig 1). The postoperative success rate was assessed as 101/123 (82.1%), 118/146 (80.8%) and 121/159 (76.1%) for each 1-, 3-, 5-year after surgery (Table 2).

Fig 1
(A) Change in mean total IPSS, voiding and storage symptom subscores from baseline to 36 months postoperatively; (B) QoL scores; (C) maximal flow rates (Qmax); (D) PVR urine volume; (E) PSA; and (F) Total prostate volume and transitional zone volume.
Table 2
Criteria for determining the 1-, 3-, and 5-yr efficacy of individual domains (symptoms, QoL, and function) and proportion of patients for each efficacy grade.

Among the preoperative variables that were suspected of affecting HPS-PVP outcomes, presence of diabetes (OR 0.210, P = 0.017), and higher QoL scores (OR 1.554, P = 0.033) were independent risk parameters for the 1-yearear treatment success. Higher QoL score showed marginal clinical significance (OR 1.456, P = 0.054), and higher bladder outlet obstructive index were the independent predictors of the 3-year treatment success. Higher voiding symptom scores (OR 1.157 P = 0.022), and lower maximal cystometric capacity (OR 0.993 P = 0.021) from urodynamic study were the independent parameters for predicting 5-year treatment success (Table 3).

Table 3
Univariate and multivariate logistic regression analysis of preoperative predictors at 1-, 3- and 5-year postoperative success.


As mentioned earlier, over the past decade, laser techniques have been developed for BPH as a treatment alternative to TURP and open prostatectomy. GreenLight PVP was introduced in the late 1990s and is now commonly used for symptomatic BPH due to the availability of higher-energy lasers [8, 9]. There are very few studies of long-term outcomes after 120-W HPS-PVP compared with other endoscopic surgery modalities [7, 8].

In this study, the postoperative success rate was assessed as 82.1%, 80.8% and 76.1% for each 1-, 3-, and 5-year after surgery. Most of the postoperative parameters showed the best results in the first year after PVP, and thereafter it gradually declined. Although the presence of diabetes was important predictor for the 1-year postoperative success, preoperative BPH symptom scores and couple of urodynamic findings could help to predict 3- and 5-year postoperative good efficacy.

Since Malek et al. reported the first long-term follow-up results of 80-W laser PVP, several reports of long-term outcomes have been published [2124]. In a prospective 5-year follow-up study by Guo et al. of 80-W laser PVP, the reoperation rate due to urethral stricture (13%), bladder neck contracture (3%), and persistent or recurrent adenoma (18%) were much higher than other long-term results [23]. When we compared our study population with that in the study by Guo et al., although the baseline characteristics of the subjects in both studies were similar, the perioperative data, including operation times, laser energy used, and catheter indwelling times, were quite different. The operative times were longer in their study, and the laser energy used was greater. In addition, urethral catheters were required for a longer time during the perioperative period. They attributed these unsatisfactory outcomes to the inefficient tissue vaporization capacity of the former 80-W laser technique [23].

Yamada et al. reported long-term surgical outcomes and safety in a 10-year follow-up study of PVP [24]. Including repeated PVP and endoscopic internal urethrotomy, they reported a reoperation rate of 4.7%, which was comparable to the rate (4.3%). in the present study. They used both 80-W and 120-W laser PVP and concluded that the applied energy (≥ 250 kJ), preoperative IPSS (≥ 20), operation time (≥ 75 minutes), and prostate volume (≥ 80 ml) were independent significant risk factors for re-treatment after PVP [24].

The excellent hemostatic capability of GreenLight PVP is well known, even in patients with anticoagulation [7, 25]. In this study, none of the patients required transfusions. The postoperative complications in the present study were similar to those reported in other long-term series and included dysuria and mild hematuria [7, 25]. In addition, most of the cases could be managed conservatively, and the rate of urethral catheter re-indwelling and transfusion were very low (0–2%).

Hueber et al. reported that the difference in the prostate volume did not influence the efficacy and safety of PVP [26]. This was also the case in the present study, in which there was no association between postoperative voiding parameters and improvements in the prostate volume. The prostate volume showed a positive correlation only with the total operative time and applied energy. Postoperative complications, such as urethral stricture or bladder neck contracture, and the re-operation rate were not associated with the prostate volume.

The present study has some limitations due to its retrospective study design. Although most patients adhered to the prescheduled regular follow-up plan, some did not. Thus, data are missing on some patients at certain follow-up points. The drop-rate at the 5-year follow up was 42.8% (128/289). Thus, there could be a risk of selection bias and under- or over-estimation. In other words, when the patients who were not satisfied at the postoperative outcome, some patients might tend to be continuously tracked and observed or other patients might go to another hospitals and the follow-up would be interrupted. Nevertheless, to our knowledge, this is the first 5-year long-term study of a large number of patients with BPH after 120-W HPS-PVP. And this study results also provided the postoperative follow up rate after BPH surgery in real practice.


HPS-PVP is an effective and durable procedure for the treatment of BPH. The postoperative success rate was assessed as 82.1%, 80.8% and 76.1% for each 1-, 3-, 5-year after surgery. Presence of DM, voiding symptom subscore, QoL, Maximal cystometric capacity, and BOO index were valuable preoperative parameters for predicting postoperative success.

Supporting information

S1 File

Patient dataset.



This research was supported by the Materials and Components Technology Development Program of MOTIE/KEIT, Republic of Korea (10067258, Development of a holmium/thulium laser resonator for treatment of prostatic hyperplasia).

Funding Statement

This research was supported by the Materials and Components Technology Development Program of MOTIE/KEIT, Republic of Korea (10067258, Development of a holmium/thulium laser resonator for treatment of prostatic hyperplasia). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Data Availability

Data Availability

All relevant data are within the paper and its Supporting Information files.


1. Welch G, Weinger K, Barry MJ. Quality-of-life impact of lower urinary tract symptom severity: results from the Health Professionals Follow-up Study. Urology. 2002;59(2):245–50. Epub 2002/02/09. . [PubMed]
2. Unnikrishnan R, Almassi N, Fareed K. Benign prostatic hyperplasia: Evaluation and medical management in primary care. Cleveland Clinic journal of medicine. 2017;84(1):53–64. Epub 2017/01/14. doi: 10.3949/ccjm.84a.16008 . [PubMed]
3. Yeo JK, Choi H, Bae JH, Kim JH, Yang SO, Oh CY, et al. Korean clinical practice guideline for benign prostatic hyperplasia. Investigative and clinical urology. 2016;57(1):30–44. Epub 2016/03/12. doi: 10.4111/icu.2016.57.1.30 ; PubMed Central PMCID: PMCPmc4778754. [PMC free article] [PubMed]
4. Wendt-Nordahl G, Bucher B, Hacker A, Knoll T, Alken P, Michel MS. Improvement in mortality and morbidity in transurethral resection of the prostate over 17 years in a single center. Journal of endourology. 2007;21(9):1081–7. Epub 2007/10/19. doi: 10.1089/end.2006.0370 . [PubMed]
5. Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, et al. Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. The Journal of urology. 2008;180(1):246–9. Epub 2008/05/24. doi: 10.1016/j.juro.2008.03.058 . [PubMed]
6. Rassweiler J, Teber D, Kuntz R, Hofmann R. Complications of transurethral resection of the prostate (TURP)—incidence, management, and prevention. European urology. 2006;50(5):969–79; discussion 80. Epub 2006/02/14. doi: 10.1016/j.eururo.2005.12.042 . [PubMed]
7. Son H, Song SH, Paick JS. Current laser treatments for benign prostatic hyperplasia. Korean journal of urology. 2010;51(11):737–44. Epub 2010/12/18. doi: 10.4111/kju.2010.51.11.737 ; PubMed Central PMCID: PMCPMC2991569. [PMC free article] [PubMed]
8. Nair SM, Pimentel MA, Gilling PJ. A Review of Laser Treatment for Symptomatic BPH (Benign Prostatic Hyperplasia). Current urology reports. 2016;17(6):45 Epub 2016/04/08. doi: 10.1007/s11934-016-0603-5 . [PubMed]
9. Rieken M, Bachmann A. Laser treatment of benign prostate enlargement—which laser for which prostate? Nature reviews Urology. 2014;11(3):142–52. Epub 2014/03/07. doi: 10.1038/nrurol.2014.23 . [PubMed]
10. Cornu JN. Bipolar, Monopolar, Photovaporization of the Prostate, or Holmium Laser Enucleation of the Prostate: How to Choose What's Best? The Urologic clinics of North America. 2016;43(3):377–84. Epub 2016/08/01. doi: 10.1016/j.ucl.2016.04.006 . [PubMed]
11. Kollmorgen TA, Malek RS, Barrett DM. Laser prostatectomy: two and a half years' experience with aggressive multifocal therapy. Urology. 1996;48(2):217–22. Epub 1996/08/01. doi: 10.1016/S0090-4295(96)00157-4 . [PubMed]
12. Seki N, Nomura H, Yamaguchi A, Naito S. Evaluation of the learning curve for photoselective vaporization of the prostate over the course of 74 cases. Journal of endourology. 2008;22(8):1731–5. Epub 2008/08/07. doi: 10.1089/end.2007.0368 . [PubMed]
13. Son H, Ro YK, Min SH, Choo MS, Kim JK, Lee CJ. Modified vaporization-resection for photoselective vaporization of the prostate using a GreenLight high-performance system 120-W Laser: the Seoul technique. Urology. 2011;77(2):427–32. Epub 2010/10/26. doi: 10.1016/j.urology.2010.06.034 . [PubMed]
14. Gomez Sancha F, Rivera VC, Georgiev G, Botsevski A, Kotsev J, Herrmann T. Common trend: move to enucleation—Is there a case for GreenLight enucleation? Development and description of the technique. World journal of urology. 2015;33(4):539–47. doi: 10.1007/s00345-014-1339-9 [PMC free article] [PubMed]
15. Cho SY, Park S, Jeong MY, Ro YK, Son H. 120W GreenLight High Performance System laser for benign prostate hyperplasia: 68 patients with 3-year follow-up and analysis of predictors of response. Urology. 2012;80(2):396–401. Epub 2012/08/04. doi: 10.1016/j.urology.2012.01.063 . [PubMed]
16. Pereira-Correia JA, de Moraes Sousa KD, Santos JB, de Morais Perpetuo D, Lopes-da-Silva LF, Krambeck RL, et al. GreenLight HPS 120-W laser vaporization vs transurethral resection of the prostate (<60 mL): a 2-year randomized double-blind prospective urodynamic investigation. BJU international. 2012;110(8):1184–9. Epub 2012/01/20. doi: 10.1111/j.1464-410X.2011.10878.x . [PubMed]
17. Nitti VW. Pressure flow urodynamic studies: the gold standard for diagnosing bladder outlet obstruction. Reviews in urology. 2005;7 Suppl 6:S14–21. Epub 2006/09/21. ; PubMed Central PMCID: PMCPmc1477621. [PubMed]
18. Toppercer A, Tetreault JP. Compliance of the bladder: an attempt to establish normal values. Urology. 1979;14(2):204–5. Epub 1979/08/01. . [PubMed]
19. Homma Y, Kawabe K, Tsukamoto T, Yamaguchi O, Okada K, Aso Y, et al. Estimate criteria for efficacy of treatment in benign prostatic hyperplasia. International journal of urology: official journal of the Japanese Urological Association. 1996;3(4):267–73. Epub 1996/07/01. . [PubMed]
20. Ryoo HS, Suh YS, Kim TH, Sung HH, Jeong J, Lee KS. Efficacy of Holmium Laser Enucleation of the Prostate Based on Patient Preoperative Characteristics. 2015;19(4):278–85. doi: 10.5213/inj.2015.19.4.278 . [PMC free article] [PubMed]
21. Malek RS, Kuntzman RS, Barrett DM. Photoselective potassium-titanyl-phosphate laser vaporization of the benign obstructive prostate: observations on long-term outcomes. The Journal of urology. 2005;174(4 Pt 1):1344–8. Epub 2005/09/08. . [PubMed]
22. Hai MA. Photoselective vaporization of prostate: five-year outcomes of entire clinic patient population. Urology. 2009;73(4):807–10. Epub 2009/02/10. doi: 10.1016/j.urology.2008.08.502 . [PubMed]
23. Guo S, Muller G, Lehmann K, Talimi S, Bonkat G, Puschel H, et al. The 80-W KTP GreenLight laser vaporization of the prostate versus transurethral resection of the prostate (TURP): adjusted analysis of 5-year results of a prospective non-randomized bi-center study. Lasers in medical science. 2015;30(3):1147–51. Epub 2015/02/24. doi: 10.1007/s10103-015-1721-x . [PubMed]
24. Yamada Y, Furusawa J, Sugimura Y, Kuromastu I. Photoselective vaporization of the prostate: the long-term outcomes and safety during 10 years of follow-up. Journal of endourology. 2016. Epub 2016/10/14. doi: 10.1089/end.2016.0522 . [PubMed]
25. Rieken M, Ebinger Mundorff N, Bonkat G, Wyler S, Bachmann A. Complications of laser prostatectomy: a review of recent data. World journal of urology. 2010;28(1):53–62. Epub 2010/01/07. doi: 10.1007/s00345-009-0504-z . [PubMed]
26. Hueber PA, Ben-Zvi T, Liberman D, Bhojani N, Gautam G, Deklaj T, et al. Mid term outcomes of initial 250 case experience with GreenLight 120W-HPS photoselective vaporization prostatectomy for benign prostatic hyperplasia: comparison of prostate volumes < 60 cc, 60 cc-100 cc and > 100 cc. The Canadian journal of urology. 2012;19(5):6450–8. Epub 2012/10/09. . [PubMed]

Articles from PLoS ONE are provided here courtesy of Public Library of Science