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Logo of bmcmudisBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Musculoskeletal Disorders
 
BMC Musculoskelet Disord. 2017; 18: 395.
Published online 2017 September 12. doi:  10.1186/s12891-017-1694-y
PMCID: PMC5596923

Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders

Abstract

Background

This study systematically summarizes quantitative imaging biomarker research in non-traumatic neck and shoulder musculoskeletal disorders (MSDs). There were two research questions: 1) Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?, 2) Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Methods

PubMed and SCOPUS were used for the literature search. One hundred and twenty-five studies met primary inclusion criteria. Data were extracted from 49 sufficient quality studies.

Results

Most of the 125 studies were cross-sectional and utilized convenience samples of patients as both cases and controls. Only half controlled for potential confounders via exclusion or in the analysis. Approximately one-third reported response rates. In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied. The literature synthesis suggested that neck muscle size may be decreased in neck pain, and trapezius myalgia and neck/shoulder pain may be associated with reduced vascularity in the trapezius and reduced trapezius oxygen saturation at rest and in response to upper extremity tasks. Reduced vascularity in the supraspinatus tendon may also be a feature in rotator cuff tears. Five of eight studies showed an association between a quantitative imaging marker and MSD severity.

Conclusions

Although research on quantitative imaging biomarkers is still in a nascent stage, some MSD biomarkers were identified. There are limitations in the articles examined, including possible selection bias and inattention to potentially confounding factors. Recommendations for future studies are provided.

Electronic supplementary material

The online version of this article (doi:10.1186/s12891-017-1694-y) contains supplementary material, which is available to authorized users.

Keywords: MRI, MSD, Near-infrared spectroscopy, Pain, Ultrasound

Background

Soft tissue neck and shoulder musculoskeletal disorders (MSDs), namely, disorders of the muscles, tendons, ligaments, nerves, or blood vessels, are prevalent worldwide [14], are a common cause of work absence and disability [5], and impose a sizeable societal economic burden [1, 3, 4, 611].

Most options for screening, surveillance and diagnosis of proximal upper extremity MSDs depend on symptoms. Improved diagnostic and screening methods, especially objective techniques, are needed [12, 13]. A biomarker has been defined as “a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention”[14]. Quantitative medical imaging techniques are increasingly used in clinical practice and MSD research, and enable detection of potential MSD biomarkers, including functional and morphological changes. The Quantitative Imaging Biomarkers Alliance and the Terminology Working Group define a quantitative imaging biomarker as “an objective characteristic derived from an in vivo image measured on a ratio or interval scale as an indicator of normal biological processes, pathogenic processes or a response to a therapeutic intervention” [15]. Valid and reliable biomarkers could improve diagnosis and screening methods [16] and provide objective means to evaluate medical treatments and workplace interventions. Use of such biomarkers may also elucidate MSD pathomechanisms.

Three biomarkers classes are conventionally described: exposure, effect (disease), and susceptibility [17]. Herein, we have reviewed biomarkers of effect, defined as “any change that is qualitatively or quantitatively predictive of health impairment or potential impairment…” [17]. Through measurement of biomarkers of effect, pathophysiological processes may be illuminated and used to stage MSD severity, such as early biomarkers that precede disease diagnosis versus late biomarkers in already diagnosed subjects.

Previous biomarker reviews

Prior reviews on this topic include a pioneering paper highlighting the potential for MSD biomarkers to detect subclinical disease and monitor MSD severity [18], and a later MSD review article [19] focused on biochemical markers. Neither paper mentioned medical imaging. Our recent systematic review also focused on biochemical biomarkers in MSDs [20]. To our knowledge, there have been no published reviews of quantitative imaging biomarkers in neck and shoulder MSDs.

The purpose of this systematic review was to conduct a comprehensive assessment of quantitative imaging biomarkers in neck and shoulder MSDs. We aimed to answer the following two research questions:

  1. Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?
  2. Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Methods

Review team and process overview. Our review team consisted of eight researchers with expertise in musculoskeletal radiology and in epidemiologic, intervention and experimental studies, including studies on pathomechanisms within the field of work-related MSD research. The review process was as follows: 1) research questions were formulated; 2) principal concepts of the review were defined; 3) a search strategy and terms were developed (Additional file 1); 4) PubMed and Scopus databases were searched, with results pooled with articles identified from the authors’ files; 5) identified papers were screened based on pre-defined criteria (Additional files 1, 2 and 3) using a two-step procedure of primary (title and abstract) and secondary (quality) screens; 6) summary tables were created from sufficient quality papers; and 7) evidence was synthesized with respect to the two research questions. A consensus process was used throughout the review process. See Gold et al. for further details [20].

Neck and shoulder MSDs were defined as clinical diagnoses or musculoskeletal symptoms in the neck and shoulder region. These included both specific and non-specific conditions related to muscles, tendons, nerves, blood vessels or ligaments [21]. The scope of this review encompassed MSDs that occur in a work-related context [22].

Quantitative imaging biomarker was defined as an objective characteristic derived from an in vivo image or from an in vivo signal captured in response to electromagnetic radiation to detect morphology or function, measured on a ratio or interval scale as an indicator of normal biological or pathogenic processes [15]. We have focused on minimally invasive/non-invasive methods. Potential quantitative imaging biomarkers could be derived through MRI, ultrasound, far infrared thermography, near infrared spectroscopy (NIRS), laser Doppler flowmetry, and other modalities. Thus, for example, muscle oxygenation as measured through NIRS was included in this review. Because plain radiographs (x-rays) are best utilized in evaluating bone abnormalities and have poor contrast resolution, this imaging modality is not routinely indicated in soft tissue evaluation [2326]. Thus, studies using only plain radiography were excluded from this review.

Severity was operationalized as encompassing longitudinal and cross-sectional differences in symptoms.

Inclusion criteria. The current review was limited to studies on adults (age > 18 years) with non-traumatic neck and shoulder MSDs, published between June 4, 1988 and October 14, 2016 and written in English language. Potential biomarkers were examined for the following specific MSDs, as categorized by Boocock, et al. [21]: rotator cuff syndrome/shoulder tendonitis, shoulder capsulitis and thoracic outlet syndrome. Other specific MSDs included are listed in Boocock, et al. [21] Table Table2,2, although status post-whiplash, cervico-brachial fibromyalgia, and joint-related conditions were excluded. Upper extremity non-specific regional pain, namely, “neck pain”, “shoulder pain”, and “neck/shoulder pain”, was also included. We included articles that met our inclusion criteria, even if some parts of the study were consistent with the exclusion criteria; however, only results in compliance with our criteria were included.

Table 2
Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Exclusion criteria are summarized in Additional file 2.

Literature search

The search was first conducted in PubMed and combined with articles identified from the authors’ files. Articles were screened for quality. If met, a second search for papers that cited the sufficient quality articles was conducted using Scopus. Additional file 1 provides an overview of the search strategy, while Fig. Fig.11 illustrates the overall search strategy and selection procedure. PubMed search terms included both MESH terms and key words selected for two categories: neck and shoulder MSDs, and biomarkers. Search terms within each category were combined using the “OR” operator, while search terms between categories were combined using “AND”. A systematic procedure was carried out for selection of appropriate MESH terms and key words, where each search term was entered by a step-wise procedure. Fifteen articles were identified by the review team and used for refining the search and testing its sensitivity. See Additional file 4 for the search string.

Fig. 1
Flowchart of literature search

A total of 4002 articles were examined by members of the review team. The final PubMed search resulted in 3999 articles; three additional papers were added from the team members’ personal files. Primary and secondary screens were implemented (see below and Additional files 1, 2 and 3). The Scopus search identified recently published articles in PubMed that still lacked assigned MESH terms. Since a PubMed search may miss relevant studies in other databases, the Scopus search reduced this potential search strategy bias. To assure clarity and limit reviewer bias, pilot testing of evaluation criteria was conducted at each stage of the review process.

Primary screen-selection of articles

The primary screen was conducted by two independent reviewers assessing each title and abstract for eligibility based on inclusion and exclusion criteria (Additional file 2), after importing all records from PubMed into systematic review software (EPPI-reviewer4 v4.3.4, EPPI-Centre, Social Science Research Unit, Institute of Education, University of London, UK). The full text was read if necessary. A “yes” answer on any question in Additional file 2 resulted in article exclusion. Results were compared between reviewers, and consensus agreement was reached in all cases (with input from a third person in case of disagreement between reviewers). The same procedure was repeated for articles from personal files and articles found in Scopus.

Secondary screen-quality assessment and data extraction

All articles passing the primary screen were scored for quality by five review team members. The articles were randomly allocated to five different clusters; each reviewer was assigned randomly to two of these clusters. In the quality screen, each article was assessed by two independent reviewers, scores were compared, and a consensus agreement was reached after discussing disagreements (using a third reviewer as needed). Additional file 3 lists questions used for the quality assessment. These questions were derived from reporting guidelines and checklists for quality assessment in health-related research studies [2731]. Seventeen items were included in the scoring system, with each item scored as either “yes” (1 point), “unknown or not applicable” (0) or “no” (0). Scores were summed for each paper (range: 0–17). Articles scoring at or above 70% of the maximum (12/17) were labeled as “sufficient quality” and were included for data extraction. Articles scoring “no” on question 15 were excluded from data extraction. These included papers with less than appropriate statistical analysis methods, such as multiple comparisons without adjustment, and modeling without accounting for repeated measures. Data extraction items are listed in Additional file 5.

Research synthesis

Ulitizing a best evidence synthesis approach, we evaluated the number of sufficient quality articles in order to identify a particular biomarker or class of biomarkers in their potential association with MSD(s) [32]. Considering the biomarker heterogeneity, it was not possible to conduct a meta-analysis. However, it was possible to group results according to the MSD, and then by physiological process or morphology, e.g., hemodynamic and/or oxygenation indicators or muscle dimensions, within diagnoses or symptom designations. An association between a biomarker and an MSD in three or more sufficient quality studies (and at most one sufficient quality study with a null finding) was regarded as evidence that an indicator could serve as a MSD quantitative imaging biomarker. We did not design our review to present different levels of evidence.

Results

Of the 3999 articles identified through the PubMed (primary) search (Fig. (Fig.1),1), and the three papers added from authors’ files, 99 met secondary screening criteria. Ten papers were excluded after reading the entire article, and three eliminated due to inadequate statistical methods, leaving 86 articles to be scored in the secondary (quality) screen. Forty-four of these met the sufficient quality criteria score. The Scopus database search of these 44 sufficient quality papers yielded 394 citations of which 26 were determined to be non-duplicates and relevant through title and abstract review. Seventeen were eliminated at the secondary screening stage after reading the entire article. Nine articles were scored during the secondary screen, although one was eliminated from data extraction for less than appropriate statistical methods. Of the remaining Scopus identified articles, five scored at ≥12. These five were added to the 44 PubMed identified and similarly scored articles. Thus, 49 studies were regarded to be of sufficient quality for data extraction.

Secondary screen-quality assessment overview

Additional file 6 shows quality scores of all papers that had undergone secondary screening (n = 96; 86 from PubMed and 9 from Scopus). The majority had clearly defined aims, biomarkers, MSDs, and results. All but two unique studies (one longitudinal cohort represented by [3335] and the other by [36]) had a cross-sectional design, and most utilized convenience samplings of patients, for both cases and referents. Just over half of the studies controlled for confounding factors through exclusion to a particular age or gender, or through a statistical adjustment in the analysis. Thirty-four studies (37%) explicitly stated that those analyzing biomarkers were blinded to case status.

Data extraction from sufficient quality studies

Additional file 7 gives a descriptive overview of the included studies. The bulk of sufficient quality studies examined neck pain, rotator cuff tears, and trapezius myalgia and other neck/shoulder pain conditions. No sufficient quality studies examined thoracic outlet syndrome. Approximately three-quarters (19/25) of the shoulder disorder studies were conducted in populations with at least one analysis group having an average age of ≥50 years. In contrast, the mean age by analysis groups in the neck pain studies ranged from 22 to 34 years, while the mean age in neck/shoulder studies ranged from 23 to 48 years.

Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?

The majority of studies demonstrated an association between at least one biomarker and the MSD(s) examined (Table (Table1).1). Only 9/49 (18%) studies reported insignificant findings throughout [3745].

Table 1
Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?

Neck pain (10 studies)

Ten studies examined neck pain [37, 38, 4653]. Decreased muscle dimensions were observed in cases in the cervical multifidus during rest [47]. In Rahnama et al. [52], no difference in multifidus muscle thickness was observed during baseline, but there was a smaller increase in cases than in controls in muscle thickness from baseline values during isometric maximum voluntary contraction (MVC). An increased muscle shape ratio (ratio between lateral and anterior-posterior dimensions) was seen in the multifidus of cases [47]. Reduced muscle dimensions were also observed in the longus colli [48, 49], and in the semispinalis capitis on cases’ painful side [50]. Dorsal neck muscle thickness change from rest to MVC was different in neck pain cases than in controls, with a tendency toward increased semispinalis capitis thickness in controls, and increased semispinalis cervicis thickness in cases [53]. There was no difference in subcutaneous tissue thickness above the sternocleidomastoid or anterior scalene muscles [38].

Greater serratus anterior muscle activity, measured using fMRI, was observed at thoracic vertebral level 6 in cases [51]. However, less longus colli recruitment, measured by muscle thickness, was found at the greatest flexion angle during incremental nodding [49]. Elliott et al. [46] detected less fat infiltration in neck extensors in neck pain vs. whiplash patients. No difference in trapezius skin temperature, or temperature asymmetry between the left and right trapezii was observed in neck pain vs. controls [37].

Rotator cuff tear (11 studies)

Eleven studies investigated rotator cuff tears [3336, 39, 5459]. Decreased supraspinatus vascularity or blood flow was observed in two studies [55, 58], and reduced supraspinatus functional capillary density in another [54]. In patients with unilateral rotator cuff tears with night pain, increased peak systolic velocity and decreased resistance index in the anterior humeral circumflex artery was observed in the symptomatic side in comparison to the asymptomatic side [59].

Initially asymptomatic full-thickness rotator cuff tears were examined in two unique longitudinal cohorts. Increased tear dimension and tear progression rate was found in asymptomatic rotator cuff tears that became symptomatic versus those that remained asymptomatic [33]. In this same cohort, Keener et al. [34] found an increased tear enlargement risk in asymptomatic full-thickness tears and in asymptomatic partial-thickness tears versus those with rotator cuff disease, but no tear. In the other longitudinal study, greater rotator cuff tear size was observed in the anteroposterior plane in tears that became symptomatic at 3-year follow-up, although there was no difference in the tear size at baseline [36]. No such increase was observed in the other planes examined. In a cross-sectional study, there was no difference between symptomatic and asymptomatic rotator cuff tears in subacromial-subdeltoid bursal fluid amount, proportion of full- or partial-thickness tears, or tear size [39].

Concommitant to rotator cuff tears, increased dimensions been observed in particular anatomical structures. Greater rotator cable (a fibrous band spanning the insertions of the supraspinatus and infraspinatus) width and thickness were observed in those with full-thickness rotator cuff tears than in healthy subjects [57]. In full-thickness rotator cuff tears, the biceps long tendon (BLT) showed increased thickness and cross-sectional area, and decreased BLT flattening ratio (width/thickness) in comparison to controls [56]. In the first longitudinal study referred to above, greater rotator cuff tear width at baseline was observed in those with anterior supraspinatus cable disruption vs. those without such disruption [35]. However, no difference in tear width enlargement percentage was observed in a minimum of 2 years later.

Rotator cuff tendinitis (5 studies)

Five studies examined rotator cuff tendinitis [57, 6063]. Decreased subacromial distance and humerus diameter [60] were observed in cases. Joensen et al. [62] found increased supraspinatus tendon thickness in cases’ symptomatic side, while Arend et al. [63] observed a greater maximal supraspinatus tendon thickness in cases. Greater rotator cable width was observed in rotator cuff tendinosis than in healthy subjects [57]. No difference in carotid artery intima-media thickness was seen in rotator cuff tendinitis vs. controls [61].

Adhesive Capsulitis (4 studies)

Four studies examined adhesive capsulitis (frozen shoulder) [6467]. Increased coracohumeral ligament [64, 66], articular capsule [66], and axillary recess joint capsule thicknesses [65, 67] were observed in cases. Increased axillary recess and rotator interval contrast enhancement, along with axillary recess thickening were observed [65].

Shoulder impingement syndrome (5 studies)

Five studies investigated shoulder impingement syndrome [58, 6871]. Increased supraspinatus tendon thickness was observed [69]. Decreased acromiohumeral distance (i.e., subacromial distance) was found in one study [68], but not in another [69]. Park et al. [70] found a difference in mean skin temperature between sides (in unilateral shoulder impingement syndrome). Decreased overall supraspinatus blood flow was observed in cases, with less blood flow in specifically in the medial portions of the supraspinatus [58]. Increased subacromial-subdeltoid bursal thickness was observed in one imaging view in cases [71].

Shoulder pain (4 studies)

Four studies examined shoulder pain [40, 41, 61, 72]. As the diagnoses were non-specific, we were unable to place them into one of the other more specific categories. Tuite et al. [72] saw an increased labral length, thick capsule labral length and posterior recess angle in cases. No difference was seen in acromiohumeral distance (AHD) between cases and controls at rest or at 45 degrees abduction [40]. Neither was any difference observed between groups in percent change in trapezius muscle thickness between rest and during muscle contraction with shoulder abduction [41]. Rechardt et al. [61] saw increased carotid artery intima-media thickness in males 60+ with shoulder pain, but not in females or in younger cases.

Trapezius myalgia, cervicobrachial syndrome and other neck/shoulder pain (12 studies)

Seven studies examined trapezius myalgia and cervicobrachial syndrome, in which muscle hemodynamics, muscle oxygenation or muscle velocity biomarkers were assessed in the trapezius [44, 45, 7377]. Decreased muscle blood flow was observed in cases versus controls and on the painful side in unilateral cases [78]. A decrease was found in muscle relative blood volume during cold pressor stimulation [74], and oxygen saturation was reduced at baseline and in response to typing [75]. In response to an upper extremity physical task, decreased oxygenated hemoglobin (compared to baseline) was observed in the trapezius in cases, but not controls [77]. No difference in change in trapezius blood flow, or in oxygenated or deoxygenated hemoglobin in response to ergometer exercise was found [44]. Lastly, there was no change in trapezius strain rate/strain rate RMS, a muscle velocity measure, between cases and controls in response to a provocative upper extremity exercise [45].

Five studies examined neck/shoulder pain [42, 43, 7981]. Decreased trapezius blood flow was seen during and after hand grip and cold pressor tests [80]. Decreased trapezius oxygenated hemoglobin and relative blood volume was observed in response to isometric trapezius contractions [81], but no difference in trapezius blood flow was found in response to a computer work task [43]. Nilsen et al. [42] saw no decrease in finger blood flow in response to a stressful task. Minimal and maximal standardized uptake values of [18F]fluorodeoxyglucose (18F–FDG), glucose metabolism indicator evaluated by PET/CT were lower in trapezii of cases versus controls, but no difference was observed in the control gluteus maximus, even after adjusting for age, gender, smoking status and diabetes [79].

In summary, a) neck muscle size appeared to be decreased in neck pain, and b) reduced blood flow, relative blood volume and reduced oxygen saturation was observed in the trapezius at rest and in response to upper extremity tasks with myalgia and neck/shoulder pain.

Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Five of eight studies demonstrated a relationship between MSD severity and quantitative imaging biomarkers (Table (Table2).2). Four studies investigated a quantitative imaging biomarker in relation to a severity score or disease stage assessment determined during a physical examination. Neck Disability Index (NDI) was negatively correlated with longus colli cross-sectional area (CSA) and anterior-posterior distance in neck pain [48]. No correlation was observed between NDI and trapezius skin temperature [37] or with fat levels in cervical extensor muscles [46]. In rotator cuff tears or rotator cuff disease, American Shoulder and Elbow Score (ASES) was significantly decreased with advancing tear type, and with incident pain in the asymptomatic shoulder [34]. Simple shoulder test score (SST) was similarly reduced.

Six of eight studies solicited pain ratings from participants through a VAS or other means. Three neck/shoulder pain studies investigated pain severity. In Takiguchi et al. [79], minimal and maximal standardized 18F–FDG uptake values, a glucose metabolism measure, were negatively correlated with VAS pain. In one study, maximal pain response was correlated with finger skin blood flow during the first 10 min of a mentally stressful task in cases, but not controls [42]. In another study, in cases (but not controls) pain and blood flow was positively correlated in the active trapezius, and negatively correlated in the contralateral trapezius at the end of a 90 min computer task [43]. No association was observed between pain rating and longus colli CSA, anterior-posterior distance, or other quantitative imaging parameters examined [48]. Neither was VAS pain related to mean skin temperature differences in shoulder impingement syndrome [70].

In summary, very few studies reviewed found associations between quantitative imaging biomarkers and neck and shoulder MSD severity. As might be inferred from results to our first research question, functional impairment in neck pain may be associated with reduced longus colli dimensions. Functional impairment in rotator cuff disease in an asymptomatic shoulder may be correlated with increasing tear type and incident shoulder pain. In neck/shoulder syndromes, increased pain may be associated with reduced glucose metabolism and increased blood flow in the active trapezius in response to a computer task.

Discussion

In this study we have summarized the current state of quantitative medical imaging marker research in neck and shoulder MSDs by conducting a comprehensive systematic review. A critical approach was used to synthesize results for the two research questions: 1) are there quantitative medical imaging markers associated with the presence of neck and shoulder MSDs, and 2) are there quantitative medical imaging markers associated with the severity of neck and shoulder MSDs? Within the studies of sufficient quality, we found associations between quantitative medical imaging biomarkers and neck and shoulder MSDs, and were able to identify several commonalities.

Evidence was found for the following quantitative imaging biomarkers: With respect to referents, decreased neck muscle size was observed in cases with neck pain [4750, 52]. Reduced trapezius blood flow and relative blood volume [73, 74, 80, 81] and oxygen saturation at rest and in response to upper extremity tasks [75, 77, 81] occurred with trapezius myalgia and neck/shoulder pain. Lastly, reduced blood flow and altered vascular parameters were observed in rotator cuff tears [54, 55, 58, 59].

In contrast to the first research question, associations between biomarkers and the severity of neck and shoulder MSDs were observed in only a few studies. Most notably, minimal and maximal standardized 18F–FDG uptake values, a biomarker of trapezius metabolism in neck/shoulder pain, were inversely correlated with pain, indicating reduced muscle metabolism in this condition. However, this was found in only one study [79]. The small sample size resulting in reduced ranges of severity measures in many studies examining neck and shoulder MSD severity may have hampered the feasibility of detecting statistically significant results for our second research question.

A possible explanation for the decreased size of deep neck muscles in neck pain cases advanced by several articles [4750] is the development of muscle atrophy due to a long term reduction in muscle activity through either pain or reflex inhibition. This explanation is consistent with a smaller change in multifidus muscle thickness during MVC from rest in those with neck pain in comparison to control subjects [52]. In another study, cases and controls showed different patterns of muscle thickness alterations during MVC when compared with rest [53]. A possible mechanism for activity changes during muscle pain is the redistribution of activity from painful muscles or painful areas to adjacent or synergistic muscles, as described in the pain adaptation model [82]. Subjects with neck pain showed reduction in deep neck muscle activity in the longus colli [49]. This was corroborated by prior studies showing reduced strength and endurance during neck flexion tests in subject with neck pain [83, 84]. However, causal relationships cannot be deduced due to the cross-sectional design of sufficient quality studies.

The pathophysiology associated with reduced blood flow, relative blood volume and oxygen saturation with trapezius myalgia and neck/shoulder pain is not clear. Decreased oxygenation as presented by several studies [75, 77] may be related to a reduction in oxygen delivery to the muscle or to increased muscle oxygen consumption. Previous studies using muscle microdialysis found increased pyruvate and lactate, metabolites related to increased anaerobic energy production, in painful trapezius muscles [77, 85]. Findings of reduced trapezius muscle blood flow in response to physical load [73, 80, 81] or pain induced during an experiment [74, 80] does not oppose the hypothesis of reduced oxygen delivery. Reduced blood flow may be attributed to an imbalance between vasoconstriction and dilatation in muscle arterioles [86]. This imbalance could be due to aberrant activation in the sympathetic nervous system or downregulation of adrenoreceptors in the arteriole epithelium in patients with MSDs [87]. Indeed, in some sufficient quality studies in this review, patients with MSDs show aberrant sympathetic activity compared to asymptomatic controls [75, 77, 80], although adrenoreceptor expression was not investigated. Together, the reduction in blood flow and oxygen saturation may facilitate the production of muscle metabolites like lactate, which are known to influence muscle nociceptor activity.

Limitations of the review

Other techniques besides imaging are available for measuring some of the functional and morphological features or processes addressed in this review. However, these other methods for assessing biomarkers were beyond the scope of the present review. For instance, our inclusion criteria allowed for articles on photoplethysmography to measure blood pressure, but not strain-gauge plethysmography. Although the term “plethysmography” was part of our search string, no papers were found that utilized strain-gauge plethysmography in neck or shoulder MSDs. Studies using plain x-rays to the exclusion of other imaging modalities were excluded. Plain radiographs are best utilized in evaluating osteoarthritis, fractures, dislocations and other bone abnormalities, and are not routinely indicated in soft tissue MSDs [2326]. However, we may have missed some biomarkers that could be of interest such as calcifications, soft tissue swelling, or acromial abnormalities including variant acromial morphology and acromial spurs.

Methodological limitations in the articles reviewed

Selection bias - response rate

The response rate to participate could be ascertained in only 15 (31%) of the 49 sufficient quality studies. Without response rates, selection bias cannot be adequately assessed. Hence, it is unknown if the cases and controls represent the underlying population, or to what extent they may be comparable. We recommend including response rates for both cases and controls in future quantitative imaging studies.

Confounding

Approximately half of the reviewed sufficient quality studies controlled for potential confounders, either through restriction of study subjects (e.g., by age or gender) or through adjustment in the statistical analysis. With respect to the quantitative imaging parameters reviewed here, muscle oxygenation, including in the trapezius, was found to be greater in males than females in many studies [8891]. However, gender had no influence on erector spinae oxygenation in a sustained trunk extension test [92]. This latter study also found no difference in relative blood volume with respect to gender. But, literature is sparse in this area. Muscle oxygenation and blood volume responses in limb muscles are significantly influenced by both age [93] and level of exercise training [94], yet no study has looked at the effects on shoulder and neck muscles.

Trapezius muscle size is greater in males than females [91]. In a biopsy study, Lindman et al. [95] found that female trapezius muscle fibers have smaller cross-sectional areas than males, and more type II fibers. Neck muscle size may also differ by gender. Zheng et al. [96] found a greater total neck muscle volume in males versus females. However, the proportion of each muscle volume examined in comparison to total neck muscle volume was similar between genders, except for the sternocleidomastoid, longus capitis, and obliqus capitis inferior. Deep neck posterior muscles and semispinalis capitis cross-sectional areas were larger in males than females, but not after adjusting for body weight [97]. In that study, muscle shape ratio did not differ by gender. Nor were there any differences in muscle dimension by age.

Although several studies suggested that reduced vascularity in the supraspinatus tendon may be associated with rotator cuff tears, two of these studies used much younger controls than cases [55, 58] (see Additional file 7). Due to the design of these studies, it is difficult to determine whether the results were due to age or to pathology. Rudzki et al. [98] found reduced blood flow in the supraspinatus tendon in those over 40 years in their study of asymptomatic rotator cuff tears, which roughly corresponds to the differentiating age between the two groups in the above studies.

The above findings suggest that (minimally) age, gender, exercise frequency, and BMI should be collected from study subjects and controlled for, either during analysis or through selection.

Directions for future research

Despite the similarity of symptoms in neck and neck/shoulder disorders, there is a marked difference in the imaging metrics obtained in studies with these two symptom designations. Muscle dimensions have been researched in neck pain, but not in trapezius myalgia and other neck/shoulder disorders. Conversely, muscle oxygenation and relative blood volume have been explored in the trapezius, but not in other neck muscles. Future research should examine muscle dimensions in the trapezius, and muscle oxygenation and relative blood volume in other muscles.

The research on muscle dimension, oxygenation and relative blood volume has been conducted in subjects with different MSD labels, i.e., in neck pain, trapezius myalgia and neck/shoulder pain. Here, we used the diagnosis or syndrome name presented in the articles. These diagnoses or syndrome names are based on the painful region. However, the division between neck and shoulder is not clear. For example, when considering functional anatomy, the neck and upper trapezius could be considered as the same region thus rendering definitions of neck and neck/shoulder regions arbitrary. Furthermore, there are suggestions of a possible common pathophysiological mechanism in these syndromes [99].

As mentioned previously, a majority of shoulder studies were conducted in older populations (at least one analysis group with mean age ≥ 50 years), whereas the neck and neck/shoulder studies were conducted in younger populations (mean age < 50 years). This could be due partially to the average age at onset of these disorders. However, given the potential for a possible spectrum effect [100], it would be of interest to study a broader range of ages.

Only 12 of the 49 sufficient quality studies in this review listed the duration of symptoms in patients (range: 9.1–114 months), all of which durations are chronic by definition [36, 38, 40, 41, 46, 47, 64, 66, 68, 70, 73, 76, 80]. One review has determined that blood flow increases to the site of rotator cuff small tears, but that decreased vascularity is observed as tear size increases and the healing response fails [101]. This suggests that varying results in vascularity in the rotator cuff tendons may be influenced by symptom duration. In view of pathophysiological mechanism research, we recommend that quantitative imaging biomarkers be investigated in MSD patients with shorter symptom durations. We further recommend that quantitative imaging biomarker study be report the range of symptoms and their duration.

Although focused on computed tomography imaging methods, animal models would suggest that different quantitative imaging biomarkers and findings are present at different MSD stages [102105]. In humans, various quantitative imaging biomarkers reflective of underlying musculoskeletal changes are valid at different stages of disease. For instance, the AHD decrease is a late stage phenomenon. It is detectable in large chronic full-thickness rotator cuff tears, but not in earlier stages of rotator cuff disease [106]. The question of which imaging modality best captures the particular biomarker under consideration is beyond the scope of this review. Determining the most appropriate imaging modality for a given quantitative imaging biomarker is an essential area for future research.

Heterogeneity – other considerations

Quantitative imaging has the potential to be unbiased and precise, particularly in comparison to ordinal scales such as the Bigliani classification [107] sometimes used in shoulder impingement syndrome. As with all types of biomarkers, optimally, a complete analytical evaluation should be conducted for each quantitative imaging biomarker under consideration. This evaluation should include determination of limit of detection, limit of quantification, reference values in normal subjects, as well as assessing the reliability and validity of any such biomarker [108]. There are unique considerations for quantitative imaging. Sources of variability include the instrument/acquisition system, and the image measurement algorithm, as well as the patient [109]. For instance, patient motion may affect the performance of the imaging acquisition system [110], and image processing software may include a number of steps, each of which requires validation [108]. See Raunig et al. [109] for a thorough review of statistical methods for assessing technical performance in quantitative imaging. These technical considerations must be addressed prior to validating the clinical utility of any suggested quantitative imaging biomarker [108, 109].

Recommendations

Below are our brief recommendations for future quantitative imaging biomarker research:

  1. Report the response rate for all analysis groups.
  2. Carefully consider and report potential confounders, gather information on these factors from study subjects, and potentially control for them through exclusion or through adjustment in the statistical analysis.
  3. Report symptom duration and/or severity in study subjects.
  4. Clearly describe MSD case definition criteria, including a description of localization of symptoms.
  5. Prioritize quantitative imaging biomarker studies that are longitudinal.

Conclusions

Based on our comprehensive review, there is limited evidence of an association between quantitative medical imaging biomarkers and neck and shoulder MSDs. The most consistent studies suggest that deep neck muscle size holds promise as a biomarker for neck pain, and that trapezius blood flow, relative blood volume, and muscle oxygenation are worthy of consideration as biomarkers for trapezius myalgia and neck/shoulder pain. Further research is warranted. In the meantime, clinicians may find value in our findings. For instance, radiologists may wish to adjust imaging scan planes to allow better volumetric analysis, and refine protocols to better characterize blood flow. Some quantitative imaging parameters, e.g., muscle size and blood flow, are not routinely included in radiology reports. It may behoov the clinician to do so. Additionally, epidemiologists may wish to include these biomarkers in cross-sectional and prospective studies of neck and shoulder MSDs. Prospective high quality studies are needed as this discipline moves forward. Future testing should be done with regard to MSD symptom duration and severity. Results should be reported with consideration to the effects of potentially confounding factors (minimally including age, gender, and exercise), and response rates of all analysis groups should be described so that potential selection bias may be assessed.

Additional files

Additional file 1:(14K, pdf)

Search terms for musculoskeletal disorders (MSDs) and imaging markers. (PDF 14 kb)

Additional file 2:(9.3K, pdf)

Questions used in the primary screen for exclusion of articles. (PDF 9 kb)

Additional file 3:(14K, pdf)

Questions used in the secondary screen for quality assessment. (PDF 13 kb)

Additional file 4:(5.5K, pdf)

PubMed search string. (PDF 5 kb)

Additional file 5:(9.2K, pdf)

Data extraction items. (PDF 9 kb)

Additional file 6:(178K, docx)

Quality scores for each of the reviewed papers in the primary screen, including the papers of sufficient quality (≥70%) and insufficient quality (< 70%) [114159]. (DOCX 177 kb)

Additional file 7:(112K, docx)

Overview with descriptive information of included studies, by anatomical region of the disorder. (DOCX 112 kb)

Acknowledgements

None.

Funding

This study was funded by a grant from the Swedish Research Council for Health, Working Life and Welfare [Forte Dnr. 2009–1761], and by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under Award Number AR056019 to MFB.

Availability of data and materials

All data supporting our findings is contained within the manuscript and additional files.

Abbreviations

18F–FDG
[18F]fluorodeoxyglucose (Glucose analog where one hydoxylgroup has been replaced with a radioacitve fluorine-18 isotope, an indicator of tissue glucose uptake in PET)
ADP
Anterior-posterior dimension
AHCA
Anterior humeral circumflex artery
AHD
Acromiohumeral distance
ANOVA
Analysis of Variance
AS
Anterior scalene
ASES
American Shoulder & Elbow Score (A validated instrument to assess shoulder pain and function [111])
Assoc.
Associated
BA
Brachial artery
BLT
Biceps long tendon
BMI
Body mass index (A measure of body fat based on height and weight)
C3-C6
Cervical vertebrae
CCFT
Craniocervical flexion test
CHL
Coracohumeral ligament
CI
Confidence interval
CPT
Cold pressor test (A cardiovascular test involving immersion of the dominant hand up to the wrist for 1–3 min in cold water)
CSA
Cross - sectional area
HGT
Static hand grip test (A test in which the subject presses a dynamometer with their dominant hand [80])
HR
Hazard ratio
IQR
Interquartile range
Lco
Longus colli muscle
LD
Lateral dimension
LD/ADP
Muscle shape ratio (ratio between lateral and anterior-posterior dimensions)
MANOVA
Multivariate analysis of variance
MBF
Muscle blood flow
MCI
Musculoskeletal complaint severity index (Mean value of 7 pain areas [43])
MR
Magnetic resonance
MRI
Magnetic Resonance Imaging
MSTT
Maximal supraspinatus tendon thickness
MVC
Maximum voluntary contraction
NDI
Neck Disability Index (A validated instrument to assess disability due to neck pain [112])
NIRS
Near infrared spectroscopy
NS
Not significant
OHb
Oxygenated hemoglobin
OR
Odds ratio
PET/CT
Positron-emission tomography/computerized tomography
PSV
Peak systolic velocity
RCT
Rotator cuff tear
RI
Resistance index (RI = (PSV (see above) – end diastoic velocity)/PSV)
RMS
Root mean square
ROI
Region of interest
SA
Serratus anterior muscle
SCM
Sternocleidomastoid muscle
SD
Standard deviation
SIS
Shoulder impingement syndrome
SST
Simple shoulder test score (An instrument to assess shoulder functional disability [113])
SUV
Standardized uptake values (Measurment for quantification in positron-emission tomography)
T6-T10
Thoracic vertebrae
TVI
Tissue velocity imaging
VAS
Visual Analogue Scale
VO2max
Maximal oxygen uptake
ΔHHb
Change in de-oxygenated hemoglobin (Determined through NIRS, from a baseline value)
ΔOHb
Change in oxygenated hemoglobin (Determined through NIRS, from a baseline value)
ΔTHb
Change in total hemoglobin, interpreted as relative blood volume (Determined through NIRS, from a baseline value)

Authors’ contributions

Authors’ contributions

JG conceived of the systematic review, led the project, performed primary and secondary scoring, and data extraction, and led the manuscript drafting effort. DH performed primary and secondary scoring, and data extraction, and drafted the initial Methods section and results Tables. FH performed primary and secondary scoring, and drafted sections of the Discussion. AC and MB performed primary and secondary scoring. MFB and SA served as musculoskeletal biomarker and radiology consultants to the project, respectively. JG, DH, FH, AC, MB, SEM, and MFB participated in initial meetings to determine the scope of the review. All authors have read and approved the final manuscript.

Notes

Ethics approval and consent to participate

Not applicable. This is a systematic review of previously published studies.

Consent for publication

Not applicable.

Competing interests

The author(s) declare that they have no competing interests. No author evaluated their own published article during the review process.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Footnotes

Electronic supplementary material

The online version of this article (doi:10.1186/s12891-017-1694-y) contains supplementary material, which is available to authorized users.

Contributor Information

Judith E. Gold, moc.liamg@dloGEhtiduJ.

David M. Hallman, es.gih@namllaH.divaD.

Fredrik Hellström, es.gih@mortslleH.kirderF.

Martin Björklund, es.gih@dnulkrojB.nitraM.

Albert G. Crenshaw, es.gih@wahsnerC.treblA.

Svend Erik Mathiassen, es.gih@nessaihtaM.kirednevS.

Mary F. Barbe, ude.elpmet@ebraBm.

Sayed Ali, ude.elpmet.shut@ilA.deyaS.

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