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Kidney Res Clin Pract. 2017 September; 36(3): 296–297.
Published online 2017 September 30. doi:  10.23876/j.krcp.2017.36.3.296
PMCID: PMC5592898

Staphylococcal infection-associated crescentic immunoglobulin A nephropathy

A 49-year-old man without a history of chronic disease presented to our hospital with acute fever, dyspnea, and oliguria. His vital signs were: blood pressure 100/60 mmHg, heart rate 120 beats per minute, and body temperature 38.5°C. Laboratory findings were: serum creatinine 2.99 mg/dL, leukocytes 21,230 × 103/μL, hemoglobin 7.6 g/dL, platelets 60,000/μL, and C-reactive protein 183.46 mg/L. Additionally, perinuclear anti-neutrophil cytoplasmic antibody (ANCA) and cytoplasmic ANCA were elevated, and C3 was decreased. However, there were no indications of vasculitis. Computed tomography revealed multifocal pneumonic infiltration along with bilateral cavitary lung lesions and a perirenal hematoma. We initiated empirical antibiotics. Blood cultures revealed methicillin-resistant Staphylococcus aureus, and the patient exhibited signs of uremia, for which he underwent emergency hemodialysis. Echocardiography revealed a tricuspid valve vegetation measuring 2.0 × 0.79 cm. While his renal function and pneumonic infiltration improved after 4 weeks, proteinuria persisted. A renal biopsy showed endocapillary proliferation and increased mesangial immunoglobulin A (IgA) accumulation accompanied by fibrocellular crescents (Fig. 1)–findings typically observed in crescentic IgA nephropathy. We initiated steroid therapy after ensuring complete remission of Staphylococcus infection. The patient’s renal condition stabilized following steroid administration.

Figure 1
Renal biopsy findings

Infectious endocarditis often results in proliferative or crescentic glomerulonephritis (GN), primarily presenting as acute kidney injury. Additionally, the histological pattern of Staphylococcus infection-associated GN resembles IgA nephropathy more than other post-infection GN. Thus, Staphylococcus-associated GN mimicking crescentic IgA nephropathy should be considered in the differential diagnosis of cases showing sudden development of azotemia and significant proteinuria in patients diagnosed with staphylococcal endocarditis. However, while steroids form the mainstay of treatment for crescentic IgA nephropathy, Staphylococcus-associated GN is primarily treated with antibiotics. Steroid therapy could be administered following complete remission of infection in patients who demonstrate fibrocellular crescents and severe proteinuria.

Acknowledgments

This work was supported by Wonkwang University in 2017.

Footnotes

Conflicts of interest

All authors have no conflicts of interest to declare.


Articles from Kidney Research and Clinical Practice are provided here courtesy of Korean Society of Nephrology