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Lung India. 2017 Sep-Oct; 34(5): 485–487.
PMCID: PMC5592769

Unusual presentation of lung cancer as skeletal muscle and subcutaneous metastases

Sir,

Metastases involving the brain, bone, liver, adrenal glands, and lymph nodes are well known in lung cancer. It is rare to have soft tissue metastasis in a lung cancer, with a reported overall incidence of 2.3%.[1] Skeletal muscle or subcutaneous metastasis could be an initial presentation of an occult primary lung cancer. A high index of suspicion is necessary in these cases as soft tissue metastases are not only rare but also carry poor prognosis.

A 67-year-old woman, a nonsmoker, presented with a painless and slow growing swelling in the right suprascapular region. She noticed it for the past 1 month. There was no history of tuberculosis. She had no chest pain, loss of weight, or loss of appetite. On examination, the mass was located in the suprascapular region, approximately 3 cm × 3 cm in size, immobile and nontender with normal overlying skin. There was also a lymph node palpable in the left side of the neck. Her blood pressure was 139/70 mmHg, pulse was 81/min, and respirations were 19/min. Systematic review of other systems was unremarkable.

Chest radiograph of the patient showed a spiculated right suprahilar opacity highly suspicious for a lung tumor. Computed tomography (CT) of neck and chest showed peripherally-enhancing lesions with central low attenuation involving the left levator scapulae muscle [Figure 1] (correlating to the clinically-suspected lymph node), subcutaneous tissue of right suprascapular region at T1 vertebral level [Figure 2] (corresponding to the clinically palpable suprascapular mass). There was a central necrotic mass in the upper lobe of the right lung [Figure 3]. Biopsy of the lung lesion revealed squamous cell carcinoma. Her sputum was negative for acid-fast bacilli.

Figure 1
Contrast-enhanced computed tomography image of the neck shows peripherally -enhancing lesion with central low attenuation in left levator scapulae muscle (arrow)
Figure 2
Contrast-enhanced computed tomography image of the upper chest shows a peripherally - enhancing lesion with central low attenuation in subcutaneous tissue of the right suprascapular region (arrow)
Figure 3
Contrast-enhanced computed tomography image of the chest shows a speculated mass lesion with central necrosis in the upper lobe of the right lung (arrow)

CT of the abdomen (images not shown) revealed further lesions in the left erector spinae, right rectus abdominus and left gluteus medius muscles. There were also focal lesions in liver and head of pancreas. The patient was given chemotherapy consisting of three cycles of gemcitabine and carboplatin. Follow-up CT at 3 months and 5 months intervals showed further worsening of primary lesion and metastases involving the lung and liver, with the appearance of multiple bone metastases. The patient was switched to new regimen consisting of three cycles of gemcitabine and cisplatin. Due to the progression of metastases, she eventually developed functional decline, sepsis, and desaturated. Supportive care was given. She died approximately 8 months after the initial diagnosis.

Metastasis involving the skeletal muscle is rare, with lung carcinoma being the most common primary. Prevalence of muscle metastases in lung cancer varies from 0% to 0.8%.[2] Pop et al.[3] found 114 cases of nonsmall cell lung cancer with skeletal muscle metastases in a literature search (during the period 1946–2007). Pain was the most frequent presentation (83%) of muscle metastasis and about 78% of muscle metastases were palpable at the time of presentation. Other modes of presentations include painless lump and asymptomatic masses seen accidentally following trauma.[2,3] In our patient, the presentation was painless swelling in subcutaneous tissue (suprascapular region) and skeletal muscle (levator scapulae muscle). Surov et al.,[4] in their retrospective study using PubMed search and database of their institution, analyzed a total of 461 patients with skeletal muscle metastases from various primaries. They described five different imaging features of muscle metastasis. Type I - round to oval mass with homogeneous enhancement, Type II - lesions with peripheral enhancement and central low attenuation, Type III - diffuse infiltration with inhomogeneous enhancement, Type IV - intramuscular calcifications, and Type V - intramuscular bleeding. They also emphasized that metastasis with Type II imaging feature occurred more often in lung cancer compared to other primaries, which was also present in our patient. Tuoheti et al.[5] described the presentation of muscle metastasis as a painful mass with peritumoral enhancement on imaging that favors metastasis than sarcoma. Acute local presentation, signs of sepsis, and history of intravenous drug abuse are useful features that help differentiate abscess from muscle metastasis.[3] No clear distinction is available in the literature between cutaneous and subcutaneous metastases.[1] The incidence of skin metastasis from lung cancer varies between 1% and 12%[6] with chest, back, abdomen, head and neck region being the frequent sites.[7,8] In patients with multiple soft tissue metastases, chemotherapy is the main-stay of treatment option.[3,7] Our patient, unfortunately, did not respond to chemotherapy and died 8 months after the initial diagnosis. Patients presenting with skin or muscle mass as initial presentation of lung cancer have a poor prognosis, and high index of suspicion is necessary in such cases to look for occult primary lung malignancy.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

REFERENCES

1. Sinha N, Niazi M, Diaz-Fuentes G, Duncalf R. An innocent appearing subcutaneous nodule diagnoses a small cell lung cancer in a never-smoker female. Case Rep Oncol Med. 2014;2014:268404. [PMC free article] [PubMed]
2. Perisano C, Spinelli MS, Graci C, Scaramuzzo L, Marzetti E, Barone C, et al. Soft tissue metastases in lung cancer: A review of the literature. Eur Rev Med Pharmacol Sci. 2012;16:1908–14. [PubMed]
3. Pop D, Nadeemy AS, Venissac N, Guiraudet P, Otto J, Poudenx M, et al. Skeletal muscle metastasis from non-small cell lung cancer. J Thorac Oncol. 2009;4:1236–41. [PubMed]
4. Surov A, Köhler J, Wienke A, Gufler H, Bach AG, Schramm D, et al. Muscle metastases: Comparison of features in different primary tumours. Cancer Imaging. 2014;14:21. [PMC free article] [PubMed]
5. Tuoheti Y, Okada K, Osanai T, Nishida J, Ehara S, Hashimoto M, et al. Skeletal muscle metastases of carcinoma: A clinicopathological study of 12 cases. Jpn J Clin Oncol. 2004;34:210–4. [PubMed]
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8. Nguyen NC, Chaar BT, Osman MM. Prevalence and patterns of soft tissue metastasis: Detection with true whole-body F-18 FDG PET/CT. BMC Med Imaging. 2007;7:8. [PMC free article] [PubMed]

Articles from Lung India : Official Organ of Indian Chest Society are provided here courtesy of Wolters Kluwer -- Medknow Publications