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Logo of bmriBioMed Research International
Biomed Res Int. 2017; 2017: 7640820.
Published online 2017 August 28. doi:  10.1155/2017/7640820
PMCID: PMC5592405

Retracted: High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex

BioMed Research International has retracted the article titled “High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex” [1]. A series of very similar articles on shRNA and cancer cell lines was identified by Byrne and Labbé [2], and the intertextual distance between this article and an article in the series [3] is lower than expected by chance. The following concerns were found:

  1. The supposed nontargeting control shRNA sequence, 5 GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3, targets TPD52L2 (NM_199360). The same sequence was used as a nontargeting control in other articles identified by Byrne and Labbé.
  2. The article is very similar in methods and structure to two other studies that also use this incorrect sequence [4, 5].

The authors did not respond to requests for comment.


1. Huang X., Zhou W., Zhang Y., Liu Y. High expression of ptgr1 promotes NSCLC cell growth via positive regulation of cyclin-dependent protein kinase complex. BioMed Research International. 2016;2016 doi: 10.1155/2016/5230642.5230642 [PMC free article] [PubMed] [Cross Ref]
2. Byrne J. A., Labbé C. Striking similarities between publications from China describing single gene knockdown experiments in human cancer cell lines. Scientometrics. 2017;110(3):1471–1493. doi: 10.1007/s11192-016-2209-6. [Cross Ref]
3. Wang Y., Jin T., Dai X., Xu J. Lentivirus-mediated knockdown of CEP55 suppresses cell proliferation of breast cancer cells. BioScience Trends. 2016;10(1):67–73. doi: 10.5582/bst.2016.01010. [PubMed] [Cross Ref]
4. Zhao X., Chen M., Tan J. Knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cancer. Biological Research. 2016;49(1) doi: 10.1186/s40659-016-0086-3. [PMC free article] [PubMed] [Cross Ref]
5. Zhang C., Fu J., Xue F., et al. Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis. World Journal of Surgical Oncology. 2016;14(1, article no. 129) doi: 10.1186/s12957-016-0891-8. [PMC free article] [PubMed] [Cross Ref]

Articles from BioMed Research International are provided here courtesy of Hindawi